ライフサイエンスコーパス: molecular

1 population genetic simulations suggest that molecular adaptation is consistently underestimated in n

2 istic understanding of AD, single cell-based molecular alterations are largely unknown.

3 Integrated RNA sequencing, metabolomics, and molecular analyses showed that OXPHOS(high) BAP1 mutant

4 If appropriate immunostainings and molecular analysis are not performed, the subtle infiltr

5 alignancy, as an incidental discovery during molecular analysis of a nonhematologic neoplasm, after h

6 uron pre-synaptic terminals, as quantitative molecular analysis shows that only a subset of these are

7 A molecular analysis was conducted using six chloroplast D

8 f the thiophene moiety strongly improves the molecular anchoring by forming covalent bonds between mo

9 s applied on macroscopic scales, whereas the molecular and atomic building blocks behave like rigid p

10 lele ("maternally expressed") to explore the molecular and cellular consequences of imprinted miRNA a

11 intrinsic kinetic mechanism to result in new molecular and cellular functionality.

12 These findings have implications for the molecular and cellular mechanisms of cerebral cavernous

13 Confocal microscopy and molecular and classical microbiology were used to invest

14 rst 4 or 12 weeks of life prevented abnormal molecular and cognitive phenotypes in rT1, demonstrating

15 nabinoids can also alter the brain's initial molecular and epigenetic response to cocaine.

16 A combination of molecular and functional profiling of bone marrow and pe

17 types exist between CRCs due to intertumoral molecular and genomic variation, and differences in envi

18 re grouped into three major classes based on molecular and morphological characteristics: surface gli

19 Our results identify new molecular and morphological traits associated with peric

20 functional heteromers mediating maladaptive molecular and motor responses in the dopamine-denervated

21 Natural lung aging is associated with molecular and physiological changes that cause alteratio

22 ng highly accurate PESs for relatively large molecular and reactive systems.

23 s should be carefully interpreted using both molecular and serological findings.

24 We cover the molecular architecture and catalytic mechanisms that dis

25 many diagnostic manufacturers have developed molecular assays for SARS-CoV-2 under the Food and Drug

26 s a performance comparable to those of other molecular assays for the detection of B. pertussis and B

27 nt analogs of animal complexes with distinct molecular assemblies, including a megadalton-scale tRNA

28 ective on the promises of ENS for developing molecular assemblies/processes for functions.

29 1A-AKT pathway ignited by NANOG is a central molecular axis and a potential target for immune-refract

30 Spectral interferences of the molecular bands of PO and NO as well as the iron lines w

31 rategies, which directly provides the direct molecular-based design of functionalized polymer/carbon

32 e challenges to understanding the underlying molecular basis for each of the many clinical features o

33 bubble, provide structural insights into the molecular basis for malfunction of disease-associated XP

34 the autophagic machinery, thus providing the molecular basis for selective degradation of sizable cyt

35 uman and mouse NaCTs and provide a plausible molecular basis for the differences based on a full-leng

36 combined data provide information about the molecular basis for the protein's functionality and a vi

37 nnel activity of gap junctions; however, the molecular basis for these effects remains unknown.

38 Here, we establish a structural-molecular basis for these observations.

39 -N-acetylated PNAG oligosaccharides, but the molecular basis for this increased activity is not known

40 We have addressed the molecular basis for this intramolecular communication by

41 confluence of detailed understanding of the molecular basis of HbF gene expression, coupled with the

42 s systematically attempted to understand the molecular basis of imaging traits based on the interpret

43 for the first time a novel insight into the molecular basis of sinonasal mucociliary differentiation

44 e we review the current understanding of the molecular basis of telomeropathies and highlight experim

45 lso help to improve our understanding of the molecular basis of tumor development and GSL metabolism.

46 ) is of great importance in stereochemistry, molecular biology and pharmacology(2).

47 ing from electrophysiological recordings and molecular biology to confocal microscopy in primary cort

48 bility with numerous different histological, molecular biology, and analytical techniques.

49 lity due to its ability to spatially resolve molecular biomarkers directly from sectioned tissues.

50 e or absence of distinct DNA strands, called molecular bits (molbits).

51 tive evidence from multiple levels including molecular, brain, and behavioral indicates that these ep

52 molecule with atomic precision and forming a molecular bridge between the metallic STM tip electrode

53 loyment of the 12-coordinated Zr hexanuclear molecular building block (MBB) as a tetrahedral secondar

54 ages with the aid of a deuterated dialdehyde molecular building block.

55 ossibilities for the design and synthesis of molecular cages with novel topologies targeting a broad

56 anchoring by forming covalent bonds between molecular carbon and copper surface atoms.

57 It possesses an impressive diversity of molecular, cellular and circuit mechanisms, embedded in

58 llection of neurons that spatially covary in molecular, cellular, and circuit properties.

59 years in elucidating drug-induced changes at molecular, cellular, and physiologic scales of analysis.

60 Information on molecular changes in cancer-specific gene expression fac

61 more complete understanding the diversity of molecular changes that occur in these tissues may guide

62 Hsp90 is a highly conserved molecular chaperone important for the activity of many c

63 ) immunoglobulin binding proteins (BiPs) are molecular chaperones involved in normal protein maturati

64 To explore the molecular characteristics and key components of the aort

65 Demographic, laboratory and molecular characteristics were not significantly differe

66 Molecular characterization of BsAbs' epitopes not only a

67 s resolution of Orbitrap for real-time, near-molecular characterization of OAs.

68 he ultimate goal of developing an integrated molecular classification is to improve diagnostic classi

69 sing SCN (SCN(VIP)) neurons, including their molecular clock, in generating the mammalian locomotor a

70 e suggesting that cisplatin can modulate the molecular clock.

71 ts reveal a paradoxical acetylation-mediated molecular clutch that tunes transcription factor availab

72 All the steps leading to the final grafted molecular complex have been identified by DFT.

73 esent a powerful means of rapidly leveraging molecular complexity from simple feedstocks.

74 d (IR-OH) approach that sensitively measures molecular composition based on an optical microscope wit

75 olfactory metamers-pairs of non-overlapping molecular compositions that generated identical odour pe

76 However, the molecular connection between these two cellular compartm

77 Further sub-classification of clinical-molecular correlates stratified pLGG into risk categorie

78 cs data but also in detailing the histologic-molecular correlations required for looking into, and ma

79 inary lipid bilayer tethered on alkane thiol molecular cushions.

80 es used to generate these different types of molecular data are frequently obtained during routine cl

81 ome sequencing has grown, greater amounts of molecular data have helped improve the ability to detect

82 , current diagnostic criteria do not include molecular data.

83 Here, we employed the molecular degree of perturbation (MDP) score adapted to

84 s, thus also providing new insights into the molecular design guidelines for the next generation of h

85 the central acene ring is a highly effective molecular design strategy to optimize the thermoelectric

86 The unique molecular detail, accuracy, sensitivity, and dynamic ran

87 rcoiling and the dynamics of supercoiling in molecular detail.

88 These findings uncover molecular determinants critical for agonist binding and

89 tes the surface expression of Tim-3, but the molecular determinants remain poorly understood.

90 The secondary outcomes were the molecular diagnostic yield, the change in clinical manag

91 on LAMP, in a closed tube, undiluted sample molecular diagnostic.

92 ction imaging provides new opportunities for molecular diagnostics and image-guided biomedical applic

93 y has opened a new era of nucleic acid-based molecular diagnostics.

94 A challenge in biology is to associate molecular differences among progenitor cells with their

95 ation, risk stratification and assignment of molecular, disease-specific therapies to improve the car

96 Molecular disruptions within limbic brain regions and th

97 ntegron gene cassettes is proposed, based on molecular docking of plant metabolites within the ATP an

98 Kinetic, molecular docking, and site-directed mutagenesis analyse

99 gh the layer-to-layer spacing increases upon molecular dopant incorporation.

100 h like people with cancer, may have multiple molecular drivers of an otherwise common phenotype, and

101 wnstream impacts on our ability to elucidate molecular drivers of disease-associated dysbiosis across

102 acterize dynamic cellular programs and their molecular drivers, and apply it to HIV infection.

103 review, we briefly update the current small molecular drugs that could synergize with immunotherapy,

104 Ab initio molecular dynamics (AIMD) simulations confirm that alumi

105 face plasmon resonance characterization, and molecular dynamics (MD) simulations initiated from Roset

106 nance (NMR), neutron reflectometry (NR), and molecular dynamics (MD) simulations were employed to stu

107 Using steered molecular dynamics (SMD) simulations, we demonstrate tha

108 Using extended molecular dynamics and enhanced sampling free-energy sim

109 nd characterize selectivity mechanisms using molecular dynamics and X-ray crystallography.

110 Molecular dynamics based folding simulations that rely o

111 AS4b, we used complementary experimental and molecular dynamics simulation approaches to reveal a det

112 Here, using molecular dynamics simulation approaches, we found that

113 Molecular dynamics simulation results indicate high conf

114 Our molecular dynamics simulations also suggest that membran

115 the formation of transient fusion stalks in molecular dynamics simulations and a coexisting sponge p

116 Molecular dynamics simulations and studies in cells reve

117 so, we show that piecewise all-atom steered molecular dynamics simulations can provide novel atomic

118 Many molecular dynamics simulations have investigated phase s

119 Molecular dynamics simulations indicated that the onset

120 Molecular dynamics simulations of post-powerstroke myosi

121 ensemble, we performed Gaussian accelerated molecular dynamics simulations on eight BAK1 mod-forms i

122 ed a piecewise approach for all-atom steered molecular dynamics simulations to examine specific secon

123 solved by X-ray crystallography, and, using molecular dynamics simulations, the dynamics of VCBC hav

124 and theoretical predictions were made using molecular dynamics simulations.

125 large water box of standard all-atom steered molecular dynamics simulations.

126 00)(+) ion, consistent with our results from molecular dynamics simulations.

127 combine single-molecule FRET experiments and molecular dynamics studies to elucidate slipping dynamic

128 Electronic Structure Methods, Non-Adiabatic Molecular Dynamics, and Theoretical Spectroscopy represe

129 (THz) absorption spectroscopy and ab initio molecular dynamics, we have investigated the ambient wat

130 racting phenomenon, supracence only measures molecular emission above its excitation energy due to en

131 Our results show that molecular endotypes exist in AP and reflect biological p

132 However, the molecular events underlying HIV neuropathogenesis remain

133 : the relative temporal ordering of cell and molecular events was not absolute, suggesting cell progr

134 of the spatial and temporal location of key molecular events, which may guide the evaluation of new

135 However, the molecular factors that influence and control the switchi

136 ranslation-elongation speed is influenced by molecular factors within mRNA and protein sequences.

137 acterized by a unique set of cytogenetic and molecular features distinct from de novo AML.

138 -through which a clinician can distinguish a molecular finding from a clinicomolecular diagnosis of g

139 Thus, both the molecular function of STEAP1 and its role in cancer prog

140 ests designed to evaluate the performance of molecular generators.

141 Molecular glue compounds induce protein-protein interact

142 roader use of gHDX in MS-based workflows for molecular identification and isomer differentiation.

143 Molecular identification of vesicular glutamate transpor

144 mutations may alter the predictive values of molecular imaging agents for endocrine therapy response.

145 e current relationship between genotypes and molecular imaging phenotypes.

146 Joint analysis for the phenotypic and molecular information maximized a comprehensive estimate

147 the development of knockout mouse models and molecular inhibitors unique to necroptotic proteins, thi

148 e design of molecular translators to convert molecular inputs into generic output sequences, which al

149 as hampered efforts to better understand the molecular interactions governing disease progression.

150 ways of TSPO ligands, which could reveal the molecular interactions governing ligand residence time.

151 to challenge the theoretical description of molecular interactions.

152 uantum-logic techniques to prepare a trapped molecular ion in a single quantum state, drive terahertz

153 , requiring in-depth characterization of the molecular landscape shaping these complex phenotypes.

154 istics of an acidic zeotype framework at the molecular level can provide valuable insights in underst

155 limation (i.e., physiological changes at the molecular level) in the clams' responses to environmenta

156 ile ATL and ATL-UvrA complexes on DNA at the molecular level.

157 NMR-based molecular-level characterization identified the docking

158 Molecular-level models for these effects have far-reachi

159 a regioselective manner to synthesize large molecular libraries for studying structure-activity prof

160 ed in a profound insight in in vitro gastric molecular lipolysis mechanisms.

161 dd to the growing body of evidence that AAA+ molecular machines generate translocating forces by a co

162 his multi-omic and bioinformatic analysis, a molecular map of exercise will be established.

163 It may model and analyse molecular marker data with or without allele dosage info

164 of polymorphic, informative, and functional molecular markers are essential for studying a wide rang

165 Universal molecular markers have been used to identify these speci

166 t trait and further allow the development of molecular markers to utilise this trait to exploit homoe

167 theoretical framework to combine quantum and molecular mechanics methods, and compute the effect of m

168 split, our current knowledge of cellular and molecular mechanism driving root development is mainly b

169 The underlying molecular mechanism for its establishment is much less u

170 This work furthers our understanding of the molecular mechanism of CD81 cholesterol sensing, how thi

171 Here, we show a molecular mechanism of how plants can sense parasitic Cu

172 repress gene expression, yet the underlying molecular mechanism remains uncertain.

173 The molecular mechanism underlying the functional conversion

174 s identify a plausible temperature-dependent molecular mechanism, which contributes to the robustness

175 To gain insight into the molecular mechanisms and determinants of gene expression

176 To identify the molecular mechanisms and novel therapeutic targets of la

177 t also hampers its treatment; the underlying molecular mechanisms are poorly understood and warrant i

178 r, little information is known regarding the molecular mechanisms associated with the regulation of t

179 We show the cellular and molecular mechanisms contributing to the dysfunctional i

180 anscriptome analyses and can lead to precise molecular mechanisms for understanding complex human dis

181 We speculate that the molecular mechanisms giving rise to the internal frictio

182 inheritance patterns, arrhythmic risks, and molecular mechanisms of CASQ2-CPVT was sought through an

183 This study investigates the molecular mechanisms of environmental factors in FECD pa

184 In our quest to determine the molecular mechanisms of its antiviral activity, we show

185 two applications using Primo to examine the molecular mechanisms of known susceptibility loci and to

186 cant gaps remain in our understanding of the molecular mechanisms ProQ uses to interact with RNA.

187 of the small GTPase MglA, but the underlying molecular mechanisms remain elusive.

188 Exploring the molecular mechanisms that prevent inflammation during ca

189 owth in G(1) provides one of the long-sought molecular mechanisms that promotes cell size homeostasis

190 Molecular mechanisms that prompt or mitigate excessive a

191 avior, but little is known about the precise molecular mechanisms that underlie this process.

192 Here, we review current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regu

193 The molecular mechanisms underlying NASH development remain

194 ght-adapted states have been determined, the molecular mechanisms underlying photoactivation remain e

195 However, the molecular mechanisms underlying the failure of beta-cell

196 The molecular mechanisms underlying the formation of coronar

197 in's functionality and a view of its complex molecular mechanisms.

198 We aimed to identify molecular mediators of these effects, focusing on long-l

199 This issue of Molecular Microbiology includes a paper by Korshunov et

200 l contributions are honored in this issue of Molecular Microbiology.

201 proteomics allows us to obtain snapshots of molecular microenvironments with nanometer resolution, f

202 Molecular modeling studies provided new insights into th

203 R) trends identified were substantiated by a molecular modeling study, based on a receptor-driven doc

204 Molecular motors are at the heart of cellular machinery,

205 The mechanical work produced by arrays of molecular motors can be used to induce a macroscopic eff

206 a set of protein assemblies that function as molecular motors to couple the energy of nucleoside trip

207 that have been used to re-engineer existing molecular motors to have, for instance, altered speed, p

208 Cellular function requires molecular motors to transport cargoes to their correct i

209 n through S phase of the cell cycle, but the molecular nature of this requirement has remained elusiv

210 We further investigated the molecular network supporting the CCB system and found th

211 t NetPAS can take topological constraints of molecular networks into account and offer new perspectiv

212 nologies have enabled mapping of the complex molecular networks that govern cellular behavior.

213 ory to obtain insight into the properties of molecular nitric acid at the surface of liquid water (th

214 The singly occupied molecular orbital (SOMO) of this hydrocarbon radical res

215 occupied molecular orbital-lowest unoccupied molecular orbital energy levels and enhance the pai-conj

216 ich signifies the tuning of highest occupied molecular orbital-lowest unoccupied molecular orbital en

217 Thanks to the nature of molecular orbitals, the absorption spectra of organic se

218 Here, various molecular organic semiconductors (OSCs), with known exci

219 lt, embraces offer a possible way to control molecular organization in materials.

220 umbrella term for an array of derivatives of molecular oxygen that occur as a normal attribute of aer

221 One molecule generator, based on match molecular pairs, performed excellently against all tests

222 Molecular pathogenesis is preserved between V-EoE and L-

223 his study, the contributions of GRA12 to the molecular pathogenesis of T. gondii infection were exami

224 Inputs to molecular pathways that are the backbone of cellular act

225 dissect the molecular pathways that respond to the state of glucose

226 nhancers engaged in the control of divergent molecular pathways.

227 and negatively regulates pathogen-associated molecular pattern-triggered immunity.

228 cytokines and damage- or pathogen-associated molecular patterns (DAMPs/PAMPs) from blood with high ef

229 e with the recognition of microbe-associated molecular patterns (MAMPs) via pattern recognition recep

230 verse stimuli, including pathogen-associated molecular patterns (PAMPs)(1).

231 hed intestinal immune responses to bacterial molecular patterns and resulted in the expansion of lyso

232 singly, stories are told using computational molecular physics (CMP).

233 ed by the interplay of 2 distinct underlying molecular processes.

234 We compared the molecular profiles of canine gliomas with those of human

235 Each subgroup displayed different molecular profiles.

236 Molecular profiling was successful in 93.0% of specimens

237 ypes and indicate that EMT involves multiple molecular programs.

238 nce that the two pools of Lck have different molecular properties.

239 ating circuit in the brainstem with a common molecular property.

240 igahertz(3), highlighting the versatility of molecular qubits.

241 genes and 39,806 noncoding regions for which molecular rates were significantly related to rates of b

242 Molecular recognition of carbohydrates is a key step in

243 ta-caryophyllene is among the most difficult molecular recognition tasks.

244 lly homogeneous current switching (driven by molecular redox) in memristors based on Ru-complexes of

245 nder realistic conditions and within dynamic molecular regimes often remain difficult to ascertain.

246 Our understanding of the molecular regulation of aging and age-related diseases i

247 Molecular regulation, on the other hand, involves tuning

248 this hypothesis, expanding the knowledge on molecular relationships between gene expression and mine

249 natumomab; the percentage of patients with a molecular response increased further after additional bl

250 therapy (day 85), 29% of the patients had a molecular response, and this percentage increased to 60%

251 lates to HCV entry, and CD81's function as a molecular scaffold; these insights are relevant to CD81'

252 Molecular science entails the study of structures and pr

253 s) offer a unique and innovative approach to molecular sensing.

254 rface-enhanced Raman scattering (SERS)-based molecular sensors for detection of two putative fatty ac

255 ated medulloblastomas were restricted to the molecular SHHalpha subtype(4) and characterized by unive

256 eal a surprising bidirectional regulation of molecular signaling between sensory neurons and non-targ

257 we rationally design a DNA-based artificial molecular signaling system that uses the confined microe

258 to extract the direction processes from the molecular signals in order to derive the distribution of

259 A potential molecular signature based on oncomirs from SEVs (caf-miR

260 targets that require cellular resolution and molecular specificity.

261 ation and systematic characterization of the molecular structure of cutin.

262 be used for prospective prediction from the molecular structure without the need for experimental da

263 leation and its independence of the detailed molecular structure.

264 blish that evolution can produce new complex molecular structures and functions via simple genetic me

265 urface enable not only direct observation of molecular structures but also local probe reactions, in

266 I experiment enable researchers to visualize molecular structures in complex tissues that have remain

267 logically distinct and clinically actionable molecular subset of SCCs that are uniquely amenable to H

268 and control brains to identify a convergent molecular subtype of ASD with shared dysregulation acros

269 ed into four biologically distinct consensus molecular subtypes (CMS1-4) using gene expression.

270 this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in res

271 The incorporation of molecular switches in organic structures is of great int

272 ns, supra-linear responses, and long-lasting molecular switches.

273 zation of dithienylethenes, a major class of molecular switches.

274 The present study unravels a new molecular system for vesicle-based axonal transport of p

275 In molecular systems, optically addressing ground-state spi

276 Molecular tagging involves the selective modification of

277 In this review, the effectiveness of molecular tagging methods incorporating carbon, silicon,

278 Importantly, the complexity of molecular target interactions, such as protein-protein i

279 We identified cell signaling molecular targets by meta-analysis of microarray data se

280 c analysis of dietary information may reveal molecular targets for disease prevention and treatment.

281 vides new pharmacological content, including molecular targets in the malaria parasite, interaction d

282 a force-activatable emitter reporting single-molecular tension events and the associated cellular for

283 Our data suggest that EMC4 and EMC7 act as molecular tethers, inter-connecting two intracellular co

284 For example, conserved molecular thermosensors, including thermosensitive chann

285 is being redefined by the development of new molecular tools, tumour modelling systems and precise in

286 This motivated the design of molecular translators to convert molecular inputs into g

287 neous collection of disorders with a complex molecular underpinning.

288 gaps in a comprehensive way in regard to the molecular underpinnings and mechanistic understanding of

289 in a commercial hatchery to investigate the molecular underpinnings of the innate immune response of

290 e analogous to vertebrate myeloid cells, yet molecular underpinnings of the lymph gland hemocytes hav

291 of the tumor microenvironment (TME) and its molecular underpinnings remain largely unstudied.

292 ed that our method could detect HCP with low molecular weight (11 kDa and 17 kDa) at a concentration

293 isoprene-derived organosulfates (OSs) with a molecular weight (MW) of 212 (C(5)H(8)SO(7)), which are

294 lar hydroarylation reactions to produce high molecular weight aromatic copolymers with 1,1-disubstitu

295 ir cognate histidine kinases but also by low molecular weight phosphodonors such as acetyl phosphate

296 ntracellular [Ca(2+)] ([Ca(2+)](i)) and high-molecular-weight glycoprotein secretion.

297 Methods: Five rationally designed low-molecular-weight ligands (L1-L5) were synthesized using

298 te measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and p

299 The choice of numerous viscosity grades and molecular weights available from different manufacturers

300 ds, with diameters on the order of 20 nm and molecular weights greater than 65 kDa, through a combina