ライフサイエンスコーパス: molecular basis

1 ressed gene networks may help to clarify SCZ molecular basis.

2 bscurity of their physicochemical nature and molecular basis.

3 ymbiosis, and highlight new work probing its molecular basis.

4 e structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble

5 ty genomes are crucial for understanding the molecular basis and evolution of these traits.

6 we synthesized our current knowledge of the molecular basis and functional consequences of spontaneo

7 However, the molecular basis and importance of this process remain la

8 Here we investigated the molecular basis and in vivo significance of its reported

9 e has been great progress in identifying the molecular basis and pathomechanistic details in pseudoxa

10 However, the molecular basis and precise function of this distinctive

11 ostasis may improve our understanding of the molecular basis and regulation of NAD(+) metabolism.

12 ng deep mutational scanning to elucidate the molecular basis and underlying functional landscape of a

13 arch providing the tools to understand their molecular basis, as well as legislation providing regula

14 Our results provide insight into the molecular basis behind genotype-phenotype correlations i

15 Together, these data further clarify the molecular basis by which a nonenveloped virus escapes a

16 In particular, the molecular basis by which Ca(2+) binding affects structur

17 Together, the results suggest the potential molecular basis by which OAT1 and OAT3 modulate distinct

18 The molecular basis dictating specificity of Zika virus infe

19 imescale of threshold adaptation, defining a molecular basis for a critical model feature.

20 To determine the cellular and molecular basis for aberrant megakaryopoiesis in myelofi

21 reviews recent advances in understanding the molecular basis for AF, with a particular emphasis on re

22 choices and that interlinked feedback is the molecular basis for an irreversible transition from plur

23 nes requires a detailed understanding of the molecular basis for antibody-mediated immunity.

24 To understand the molecular basis for arrestin coupling, here we determine

25 head proteins recognize both motifs, but the molecular basis for bispecific DNA recognition is not un

26 ose synthase CesA homotrimer that suggests a molecular basis for cellulose microfibril formation.

27 general binding mode for DHP drugs, but the molecular basis for chiral specificity remained elusive.

28 tion was obtained at pH 5.5, elucidating the molecular basis for cholesterol handoff from NPC2 to NPC

29 This work revealed a complex molecular basis for cis-acting regulatory variation.

30 disorders, particularly stress, providing a molecular basis for clinical co-morbidity and for stress

31 Our results establish the molecular basis for cohesin loading onto DNA.

32 Our findings provide a molecular basis for controlling inhibitory interneuron p

33 Our results provide a molecular basis for coordinate actin bundle formation at

34 These studies reveal the molecular basis for coordinated N-terminal acetylation b

35 )CRM1) complexes with inhibitors defined the molecular basis for CRM1 inhibition.

36 the RING domain of MDM2, but the underlying molecular basis for deregulation remains elusive.

37 Our work also provides a molecular basis for developing light-based treatments fo

38 lity of the recombinant complex, providing a molecular basis for disease.

39 To understand the molecular basis for DNA adenosine deamination by adenine

40 A deeper understanding of the molecular basis for DNE may drive development of drugs t

41 e challenges to understanding the underlying molecular basis for each of the many clinical features o

42 tructural and functional studies provide the molecular basis for electrophile recognition by the extr

43 These findings suggest a molecular basis for exploiting Cu-chelation therapy to p

44 r distinct glycan acceptors, we identify the molecular basis for FUT8 specificity and activity.

45 Our study provides the structural and molecular basis for future discovery of drugs targeting

46 Despite decades of study, the molecular basis for granuloma formation and restriction

47 The molecular basis for how NatE and HYPK cooperate is unkno

48 However, the molecular basis for how the R68S variant leads to PKU re

49 The molecular basis for how these two tRNA features combine

50 Here, we elucidate the molecular basis for inhibition and activation of MORC3.

51 this antibody bound to PvDBP, indicating the molecular basis for inhibition.

52 ymnastics necessary for RNR activity and the molecular basis for its control via an evolutionarily co

53 structure of the intact cap complex, and the molecular basis for its interaction with the filament, r

54 To identify the molecular basis for lability of T3D/T1L L3S2, we screene

55 e atomic model for Mec1-Ddc2 and uncover the molecular basis for low basal activity and the conformat

56 structural characterizations that reveal the molecular basis for low-pH-dependent cholesterol deliver

57 bubble, provide structural insights into the molecular basis for malfunction of disease-associated XP

58 transcription of Notch target genes, yet the molecular basis for mastermind function remains incomple

59 This offers a straightforward molecular basis for NPA inhibition of PIN-dependent auxi

60 However, the molecular basis for oligomeric assembly is not fully und

61 To better understand the molecular basis for PAR4-dependent signaling, we examine

62 Here we investigate the molecular basis for PGC specification in Nematostella, a

63 residue at position -1, thus elucidating the molecular basis for phosphorylation site recognition.

64 synthase complexes assemble and provide the molecular basis for plant cell wall engineering.

65 despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions.

66 tions are incompletely understood, as is the molecular basis for preferential glucuronidation by UGT1

67 To understand the molecular basis for promiscuity, we solved X-ray crystal

68 These results provide a molecular basis for proposing 2OGO as a plant immunity s

69 This review focuses on the molecular basis for R-loop-mediated gene regulation and

70 d angiogenesis in vitro, thereby providing a molecular basis for removal of vitreous as cleanly as po

71 provide a more complete understanding of the molecular basis for renal recovery.

72 The molecular basis for ribosome recycling by RRF and EF-G r

73 the autophagic machinery, thus providing the molecular basis for selective degradation of sizable cyt

74 However, the molecular basis for sex disparity in SLE remains poorly

75 ation in V. cholerae Our results provide the molecular basis for studies on Hfq in V. cholerae and hi

76 associated with disease and would provide a molecular basis for targeted therapeutic strategies.

77 In this review, we examine the molecular basis for TCR activation in light of the recen

78 N enables generation of hypotheses about the molecular basis for the associations in the context of p

79 However, the molecular basis for the chronically enhanced placental a

80 These findings reveal a molecular basis for the cnidarian stinging response and

81 ner dynein arm subform c (IDAc), providing a molecular basis for the control of motor activity by mec

82 le for LL-37 in T2D pathogenesis and offer a molecular basis for the design of LL-37-derived peptides

83 uman and mouse NaCTs and provide a plausible molecular basis for the differences based on a full-leng

84 nd human-like receptors, and we identify the molecular basis for the distinctive preference for sulph

85 xacerbation of IPF, yielding insights to the molecular basis for the elevation of staphylococci in pu

86 Here we investigate the molecular basis for the evolution of Usb1 CPDase activit

87 To identify the molecular basis for the flexible site-selectivity, stere

88 The amlodipine-bound structure reveals the molecular basis for the high efficacy of the drug.

89 To understand the molecular basis for the high specificity of AceCas9 for

90 These results not only reveal the molecular basis for the I942 vs cAMP mimicry and competi

91 and class-switch recombination, providing a molecular basis for the immunodeficiency in ICF2 syndrom

92 In the present study, the molecular basis for the inhibition of host mRNA nuclear

93 These results help to define the molecular basis for the interaction between adiponectin

94 emodel in aged mice, establishing a systemic molecular basis for the long-standing proposed links bet

95 These findings help elucidate the molecular basis for the mixing vessel trait of swine and

96 These data provide a molecular basis for the neutralization of pathogenic bet

97 These studies provide insight into the molecular basis for the neutralizing human antibody resp

98 A-B*07:02/EBV(RPP) complex, which provides a molecular basis for the observed TRBV4-1 bias.

99 This study reveals the molecular basis for the plasticity of the active site of

100 The molecular basis for the propensity of a small number of

101 Still, the underlying molecular basis for the protection is unclear.

102 combined data provide information about the molecular basis for the protein's functionality and a vi

103 ing and simulation, the structure suggests a molecular basis for the recognition of formylpeptides an

104 The molecular basis for the retention of potency by this G-q

105 Moreover, by examining the molecular basis for the short circadian period of upf-1(

106 omain-dependent oligomerization provides the molecular basis for the Syt1 clamping function.

107 These findings provide a molecular basis for the weaker activity of LGR5 in the p

108 lecular dynamics simulations rationalize the molecular basis for their activity and suggest that the

109 To dissect the molecular basis for their activity, we determined the bi

110 ir complexes with AChE and BChE revealed the molecular basis for their high potency.

111 served proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity.

112 at 1.9 angstrom resolution, illuminating the molecular basis for their interaction.

113 virulence in most pathogenic fungi, but the molecular basis for their involvement is largely unknown

114 sticity of breast cancer cells and provide a molecular basis for therapeutic strategies aimed at over

115 to stress, others remain resilient, but the molecular basis for these behavioral differences is not

116 Whether there is a molecular basis for these disparities is unknown, as ver

117 nnel activity of gap junctions; however, the molecular basis for these effects remains unknown.

118 metabolomics as a tool for understanding the molecular basis for these metabolic and physiological ch

119 With this study, we aim to decipher the molecular basis for these observations by applying Fouri

120 Here, we establish a structural-molecular basis for these observations.

121 The molecular basis for this change has remained elusive.

122 However, the molecular basis for this differential growth pattern bet

123 V-2 infection is highly variable and yet the molecular basis for this effect remains elusive.

124 -N-acetylated PNAG oligosaccharides, but the molecular basis for this increased activity is not known

125 Here, we investigate the molecular basis for this increased virulence, comparing

126 Molecular basis for this interaction has remained unknow

127 nd, tissue transglutaminase 2 (TG2), but the molecular basis for this interaction is largely undefine

128 We have addressed the molecular basis for this intramolecular communication by

129 To understand the molecular basis for this observation, we determined the

130 repertoire specific for this epitope or the molecular basis for this observed immunodominance.

131 The molecular basis for this specificity is currently unknow

132 However, the molecular basis for this transformation and its distribu

133 Understanding the molecular basis for TNPO3-mediated nuclear trafficking o

134 Here, we uncover the molecular basis for transport in this widely distributed

135 o-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression.

136 important regulator of the SAN and provide a molecular basis for understanding the conduction abnorma

137 These episomes form the molecular basis for viral latency and are etiologically

138 In humans, triplet repeat expansion is the molecular basis for ~40 neurological disorders.

139 ty, neuronal firing and hormone release on a molecular basis is still largely unknown.

140 Its molecular basis is unknown.

141 Our studies reveal the molecular basis of a common activation mechanism conserv

142 inical importance, little is known about the molecular basis of A. baumannii pathogenesis.

143 Collectively, our data illuminate the molecular basis of Abeta membrane pore formation, which

144 Understanding the molecular basis of adaptation to the environment is a ce

145 hedding light on predator-prey dynamics, the molecular basis of adaptation, and patterns of convergen

146 ognition of PfCSP have recently emerged, the molecular basis of antibody-mediated inhibition of other

147 A rearrangements and are responsible for the molecular basis of antigen recognition in the immune sys

148 an heart development and homeostasis and the molecular basis of associated disease states relies on t

149 of the drug target, our understanding of the molecular basis of azole resistance in the fungal pathog

150 e VNC, we investigated the developmental and molecular basis of behavior by focusing on lineage-speci

151 We characterized the molecular basis of behavioral plasticity in queenless ho

152 functional nucleic acids for elucidating the molecular basis of biological activities and uncovering

153 ld has made great strides in elucidating the molecular basis of biomolecular phase separation in vari

154 sease risk, for understanding the underlying molecular basis of breast cancer risk factors and improv

155 e the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizi

156 ofactors and antagonists will illuminate the molecular basis of cancers that arise from a deficiency

157 e-1 in the United States, recognition of the molecular basis of carbapenem resistance allowed for suc

158 These data on the molecular basis of CCD catalysis shed light on the origi

159 r system and provide novel insights into the molecular basis of CCM disease at the single cell level.

160 y for breakthroughs toward understanding the molecular basis of cell patterning in vivo.

161 discuss recent progress in understanding the molecular basis of cell-cell recognition, including uniq

162 entalization of cellular signaling forms the molecular basis of cellular behavior.

163 proteins opens opportunities to explore the molecular basis of cellular force generation, mechanosen

164 tical analysis has provided insight into the molecular basis of cellular function, but current approa

165 induced flow perturbations to determine the molecular basis of centrosome strength and ductility in

166 To elucidate the molecular basis of cGAS inactivation by nuclear tetherin

167 ian Na(V) channels provide insights into the molecular basis of channel gating and will facilitate or

168 The molecular basis of chromatin remodeling in response to I

169 We studied the molecular basis of combined immunodeficiency in a patien

170 ional effect that can help to understand the molecular basis of complex diseases and traits, and so l

171 By exploring the molecular basis of congenital dilated cardiomyopathy (DC

172 These complex structures unveil the molecular basis of cooling agonist sensing by TRPM8 and

173 tor of SHP-induced Rgg activity, reveals the molecular basis of CsA function.

174 Despite significant progress in defining the molecular basis of DBA and increased understanding of th

175 tal cell death may provide insights into the molecular basis of developmental abnormalities and patho

176 ural resolutions, and help to understand the molecular basis of disease-causing mutations.

177 f ACE with these inhibitors has provided the molecular basis of dual inhibitor recognition involving

178 erian metazoans are key to understanding the molecular basis of early animal evolution.

179 re provide a framework for understanding the molecular basis of epigenetic maintenance mediated by Po

180 The molecular basis of epoxidation catalyzed by nonheme-iron

181 yses in these Zn-deficient rats revealed the molecular basis of ESCC abrogation by miR-31 knockout.

182 euronal maturation shedding new light on the molecular basis of functional aspects in the prolidase d

183 al roles in RNA metabolism, insight into the molecular basis of G-patch-mediated helicase activation

184 small molecules is paramount in decoding the molecular basis of gene function and designing tools to

185 confluence of detailed understanding of the molecular basis of HbF gene expression, coupled with the

186 ic ligands have delayed comprehension of the molecular basis of heparan sulfate proteoglycan function

187 utagenesis examinations further underpin the molecular basis of HI/HA dominant mutations and conseque

188 ture (HNT) has been studied, the genetic and molecular basis of HNT stress response remains unexplore

189 However, the molecular basis of how such TRAV1-2(-) TCRs interact wit

190 ated in multiple human cancers; however, the molecular basis of how these mutations contribute to onc

191 s systematically attempted to understand the molecular basis of imaging traits based on the interpret

192 es interaction, much less is known about the molecular basis of interspecies interplay.

193 , research into the genetic architecture and molecular basis of its evolution continues to yield nove

194 The molecular basis of its function, however, is unknown.

195 iate provided a structural framework for the molecular basis of its inhibitory effect.

196 To clarify the molecular basis of KLF4-mediated monocytic differentiati

197 vances in both methods and understanding the molecular basis of meiotic recombination.

198 The cellular and molecular basis of metaplasia and declining neurogenesis

199 Study of the molecular basis of myocardial fibrosis is hampered by li

200 raps will all benefit from understanding the molecular basis of nectar-seeking.

201 The molecular basis of NED is not completely understood lead

202 ain functions, opening new insights into the molecular basis of neurological disorders.

203 Here, we provide thus far unraveled molecular basis of noncysteine mutations in TNFR1 ectodo

204 from the opium poppy over 200 years ago, the molecular basis of opioid action has remained the subjec

205 ll, and permits experimental analyses of the molecular basis of optical modulation.

206 However, the molecular basis of Orn's unique cellular function remain

207 Although the molecular basis of OS structure remains unresolved, rece

208 his structure has provided insights into the molecular basis of PACAP27 binding and VIP receptor acti

209 oviding an excellent system for studying the molecular basis of parasitism and its evolution.

210 ed assays could aid our understanding of the molecular basis of PD mimetic-induced Parkinsonism and t

211 understanding of the underlying genetic and molecular basis of penicillin-induced DHRs.

212 provided by these structures establishes the molecular basis of Prim-PolC's gap recognition and exten

213 To understand the molecular basis of Prim-PolC's gap recognition and synth

214 the wide use of genomics to investigate the molecular basis of rare congenital malformations, a sign

215 nterspecies transmission, animal models, and molecular basis of receptor binding for SARS-CoV-2.

216 velopment have been intensively studied, the molecular basis of reproductive organ development in orc

217 The molecular basis of Rgg-SHP and Rgg-target DNA promoter s

218 genetic materials is needed to elucidate the molecular basis of salt tolerance mechanisms.

219 t need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis.

220 dy provides new insights into the underlying molecular basis of SCA2 SC phenotypes and demonstrates a

221 quent alteration in the TMD interactome is a molecular basis of sensing mechanical force transmitted

222 Considering the molecular basis of sequential stages of plant-pathogen i

223 uits, as well as for novel insights into the molecular basis of sex steroids actions, brain dimorphis

224 biochemical foundation for understanding the molecular basis of shared and distinct signaling propert

225 for the first time a novel insight into the molecular basis of sinonasal mucociliary differentiation

226 However, understanding the molecular basis of such a channeling mechanism remains a

227 cate and feed on warm-blooded hosts, but the molecular basis of such behavior is unknown.

228 However, the cellular and molecular basis of such responses remains undefined.

229 ng candidates for experimentally probing the molecular basis of synaptic pathology in schizophrenia.

230 ese results provide important insight into a molecular basis of T cell coinhibition by PD-1H.

231 e we review the current understanding of the molecular basis of telomeropathies and highlight experim

232 At present, the molecular basis of terminal drought tolerance of certain

233 Further understanding of the molecular basis of the above processes could identify po

234 as been little progress in understanding the molecular basis of the associated loci.

235 We sought to determine the cellular and molecular basis of the clinical benefit observed under r

236 Here, we review the molecular basis of the CoV proofreading complex and eval

237 we discuss our current understanding of the molecular basis of the development and production of the

238 ther hand, MD and aMD allowed monitoring the molecular basis of the encapsulation and guest competiti

239 The structure reveals the molecular basis of the extreme subtype specificity of MT

240 esolution of 2.7 angstrom, which reveals the molecular basis of the interaction.

241 In particular, we describe the molecular basis of the known target protection systems,

242 ogether, our results reveal the cellular and molecular basis of the nearly complete recovery of neona

243 Here, we investigate the molecular basis of the neurodegenerative disease heredit

244 or/product oligosaccharide and elucidate the molecular basis of the nonprocessive levan elongation me

245 To better understand the molecular basis of the rapid-flowering phenotype, transc

246 These findings reveal the molecular basis of the selective receptor recognition by

247 local glycan processing, thereby providing a molecular basis of the site-specific nMPO glycosylation.

248 amagnetic resonance measurements uncover the molecular basis of the so-called bridging glutamate (E20

249 well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cell-cycl

250 n of fibre-cell development and revealed the molecular basis of the temporal modulation of secondary

251 eduction of trypanothione are cytosolic, the molecular basis of the thiol redox homeostasis in the si

252 The molecular basis of the trypanocidal activity of suramin

253 wide range of geographical habitats, but the molecular basis of thermoregulation remains poorly under

254 acts autophagic function, but the target and molecular basis of these changes are unknown.

255 Recent work has focused on understanding the molecular basis of these diseases.

256 The molecular basis of this bi-directional communication rem

257 r barbed end than their pointed end, but the molecular basis of this difference has not been understo

258 The molecular basis of this differentiation is unknown, desp

259 This review aims to assess the molecular basis of this link through exploration of the

260 lysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely

261 owever, the in vivo functional relevance and molecular basis of this noncanonical role remain unclear

262 r reverse transcription and integration, the molecular basis of this phenomenon remains unclear.

263 CF sites preferentially stabilize loops, the molecular basis of this polarity remains unclear.

264 Future studies are needed to define the molecular basis of this putative association.

265 recognized for more than a century, but the molecular basis of this regional patterning is not well

266 Further understanding of the molecular basis of this restriction will provide importa

267 B41-specific antibody complex elucidate the molecular basis of this strain-specific glycan hole resp

268 We analyzed the molecular basis of this stress-related memory phenotype

269 The molecular basis of this tissue-specific tumor incidence

270 , thus enabling quantitative analysis of the molecular basis of tissue development and disease.

271 the power of this resource in uncovering the molecular basis of tissue homeostasis during normal deve

272 to improve understanding of the cellular and molecular basis of tolerance and to identify potential p

273 lso help to improve our understanding of the molecular basis of tumor development and GSL metabolism.

274 Further deciphering the molecular basis of tumour cell plasticity has the potent

275 To understand the molecular basis of vaccine-induced protection, we genera

276 mprehensive molecular profiling resolved the molecular basis of virtually all high-risk cancers, lead

277 property of stability and self-assembly, the molecular basis of which may lead to different types of

278 The molecular basis of Wnt-Frizzled specificity is a central

279 The cellular/molecular basis of ZIKV and host interactions inducing o

280 l SNHL, however, its underlying cellular and molecular basis remain unknown.

281 and reactivation are well documented but the molecular basis remains a complete mystery.

282 n essential early step in metastasis but its molecular basis remains incompletely understood.

283 eristic malignant phenotype whose underlying molecular basis remains poorly characterized.

284 However, the related molecular basis remains undetermined.

285 s of dystonia, the cellular, anatomical, and molecular basis remains unknown for most genetic forms o

286 These results offer a molecular basis supporting the current use of Sofosbuvir

287 However, the molecular basis that underlies this mechanism is largely

288 X-ray crystal structure of TnmH provides the molecular basis to account for its broad substrate promi

289 This provides a molecular basis to explain the bathochromic shift in the

290 We provide some molecular basis to this function by showing that pUL47 e

291 the Magnoliids, monocots, and eudicots; the molecular basis underlying floral scent biosynthesis; an

292 ric disorders, yet little is known about the molecular basis underlying inhibitory control.

293 periments and IC(50) measurements reveal the molecular basis underlying the inhibitory effects and se

294 The molecular basis underlying the physiological and patholo

295 However, the molecular basis underlying these beneficial effects of m

296 To identify molecular basis underlying these disparately different t

297 The molecular basis underlying this fate choice remains uncl

298 elated, thus providing new insights into the molecular basis underpinning quantitative traits and kno

299 ated with disease, HLA-DQ2.2 is not, and the molecular basis underpinning this differential disease a

300 To understand its molecular basis, we used radish to generate a compendium