ライフサイエンスコーパス: molecular mimicry

1 iruses bearing homologues of self peptides ("molecular mimicry").

2 s that are weakly reactive to self-antigens (molecular mimicry).

3 crossreactivity can occur in the absence of molecular mimicry.

4 ct with self-peptides, a phenomenon known as molecular mimicry.

5 lation) act to limit autoimmune disease from molecular mimicry.

6 ctivation of autoimmune T cells may occur by molecular mimicry.

7 proving the occurrence of infection-induced molecular mimicry.

8 miting the risk of autoimmune disease due to molecular mimicry.

9 D.radiodurans revealed striking examples of molecular mimicry.

10 a second characteristic of these systems of molecular mimicry.

11 self-reactive lymphocytes via the process of molecular mimicry.

12 crobial epitopes, consistent with neoantigen molecular mimicry.

13 multiple sclerosis (MS) potentially through molecular mimicry.

14 couples infection with autoimmune disease is molecular mimicry.

15 result of a virus infection, in part through molecular mimicry.

16 of viruses in the genesis of autoimmunity is molecular mimicry.

17 yptic self-epitopes, antigen persistence and molecular mimicry.

18 stigations are centered on the hypothesis of molecular mimicry.

19 cur by either bystander T-cell activation or molecular mimicry.

20 established trigger of the disease, suggests molecular mimicry.

21 s may provide antimicrobial activity against molecular mimicry.

22 tabolites and evade host immunity via glycan molecular mimicry.

23 P3 protein-protein interaction (PPI) through molecular mimicry.

24 a potential source of autoreactivity through molecular mimicry.

25 ing pathogens subvert this mechanism through molecular mimicry.

26 n-I (beta2GPI) and thus can induce antiCl by molecular mimicry.

27 vestigate glycan-mediated immune evasion via molecular mimicry.

28 g that their initial priming could occur via molecular mimicry.

29 t Toll-like receptor (TLR) signaling through molecular mimicry.

30 s possible triggering factors of ITP through molecular mimicry.

31 en it and self-AQP4 was observed, supporting molecular mimicry.

32 ed mechanisms with the most postulated being molecular mimicry.

33 uned structural instability and coupled with molecular mimicry.

34 tability changed in a manner consistent with molecular mimicry.

35 main, which may represent an unusual form of molecular mimicry.

36 tochondrial Ag or a similar breakdown due to molecular mimicry.

37 This surprising case of molecular mimicry (1) shows a key potential selective ad

38 l T cell-mediated autoimmune disorders, with molecular mimicry a likely mechanism.

39 In an unusual example of molecular mimicry, a negatively charged surface on this

40 e potential of virus-induced autoimmunity by molecular mimicry, a nonpathogenic neurotropic Theiler's

41 g a host inhibitory receptor via sialoglycan molecular mimicry, a novel mechanism of bacterial immune

42 infectious agent can, through the process of molecular mimicry, also recognize healthy cells.

43 individuals with type 2 disease may reflect molecular mimicries and cross-reacting autoantibodies.

44 ultaneously in the interface, not limited to molecular mimicry and CDR loop shifts.

45 hat r(UNCG) and r(GNRA) hairpin families use molecular mimicry and electrostatic factors to attain ex

46 Molecular mimicry and engagement of TLRs have been assig

47 icrobial proteins as possible substrates for molecular mimicry and for the identification of possible

48 protein A49 inhibits NF-kappaB activation by molecular mimicry and has a motif near the N terminus th

49 Here, we discuss the theory of molecular mimicry and its continued evolution from the i

50 iation of autoimmunity by mechanisms such as molecular mimicry and more toward activation of an intri

51 Here, we examine the relative roles of molecular mimicry and nonspecific inflammatory stimuli i

52 is and challenge these against mechanisms of molecular mimicry and others.

53 rgues against ZnT8 autoimmunity arising from molecular mimicry and suggests a mechanistic link betwee

54 lar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T ce

55 elopment of autoimmunity, which are based on molecular mimicry and/or the bystander effect, and sugge

56 The process termed "molecular mimicry' and the use of transgenic models in w

57 ms include abnormal microbial translocation, molecular mimicry, and dysregulation of both local and s

58 s involved in immunogenicity, pathogenicity, molecular mimicry, and immune evasion, expanding our und

59 buted to its high binding affinity, receptor molecular mimicry, and interactions with RBM backbone at

60 itope spread or drift, the bystander effect, molecular mimicry, anti-idiotype theory, antigenic compl

61 er than viral antigen recognition, and hence molecular mimicry, are at play and are sufficient to cau

62 nd is tRNA-like, suggesting the IRES employs molecular mimicry as a functional strategy.

63 tating the Esc1-Sir4 interaction and suggest molecular mimicry as a general mechanism that enables mo

64 (LOSs) of GBS-inducing microbes, suggesting molecular mimicry as a mechanism for disease induction.

65 Several studies support molecular mimicry as a mechanism for the involvement of

66 induces protective CD8+ T cells, identifying molecular mimicry as a mechanism to enforce tolerance in

67 afficking pathway, suggests the co-option of molecular mimicry as a strategy for achieving its functi

68 ity of an infectious etiology for PBC and of molecular mimicry as an etiologic mechanism.

69 Molecular mimicry as evidenced in these two stable but o

70 dimers formed by risk haplotypes, supporting molecular mimicry as the key mechanism of RHD pathogenes

71 cross-reactive T-cell recognition, known as molecular mimicry, as well as bystander T-cell activatio

72 at GBS is the best-supported example of true molecular mimicry at the B cell level.

73 possibly via triggering autoimmunity through molecular mimicry, autoantigenic presentation or immune

74 For example, molecular mimicry between a dominant T-cell epitope of B

75 These data demonstrate the importance of molecular mimicry between an infecting agent and hnRNP-A

76 Because of the immunologic molecular mimicry between bacterial and human HSP60, it

77 l autoimmunity in human lupus arises through molecular mimicry between EBNA-1 and lupus autoantigens

78 Overall, we show that molecular mimicry between EBNA1 and GlialCAM is likely a

79 he presence of cross-reactive antibodies and molecular mimicry between EBNA1 and GlialCAM, and accomp

80 These studies show molecular mimicry between epitopes of oxLDL and S. pneum

81 Molecular mimicry between foreign and self Ags is a mech

82 enesis of most human autoimmune diseases and molecular mimicry between foreign and self ligands has b

83 s that probably reflect referral biases, and molecular mimicry between foreign and self-antigens is t

84 is unknown, but autoimmunity resulting from molecular mimicry between gliadin and nervous system pro

85 remains speculative, but the possibility of molecular mimicry between glycosylated flagellin and euk

86 Molecular mimicry between HCMVpp65 peptide and host prot

87 Our results do not support the existence of molecular mimicry between HCRT and pHA(273-287) or NP(17

88 Studies that have demonstrated molecular mimicry between Helicobacter pylori and consti

89 The results suggest that molecular mimicry between HLA-B27-restricted bacterial a

90 amples of postinfectious autoimmunity due to molecular mimicry between host and pathogen.

91 r evidence linking HPV and TED, highlighting molecular mimicry between HPV capsid protein and key aut

92 Molecular mimicry between human and GAS proteins trigger

93 sis of RHVD and Spyogenes proteomes revealed molecular mimicry between human type 1 collagen epitope

94 Molecular mimicry between immunodominant autoepitopes an

95 Molecular mimicry between pathogen and host causes furth

96 primed immune cells, and autoimmunity due to molecular mimicry between pathogen and host proteins.

97 These data provide a mechanism by which molecular mimicry between pathogen and self-antigens cou

98 ion crystal structure of the complex reveals molecular mimicry between the aptamer and the 5'-triphos

99 arditis, may be autoimmunity mediated due to molecular mimicry between the bacterium Borrelia burgdor

100 Most models focus on issues of molecular mimicry between the E2 subunit of the pyruvate

101 Here we demonstrate high-affinity molecular mimicry between the EBV transcription factor E

102 We previously described molecular mimicry between the EBV transcription factor E

103 or development of myocarditis are not clear, molecular mimicry between the spike protein of severe ac

104 Molecular mimicry between viral and self antigens could,

105 ct of eliminating a sequence responsible for molecular mimicry between virus and host.

106 ity between TMEV and self epitopes (that is, molecular mimicry), but because of de novo priming of se

107 stinct strains of S. pneumoniae that utilize molecular mimicry, but that microarray platforms populat

108 tudy, we have identified the use of bivalent molecular mimicry by ADP, coopting the 5'-deoxyadenosine

109 , as well as substantiating evidence for the molecular mimicry by beta-lactam antibiotics of the pept

110 Group A Streptococcus (GAS) employs molecular mimicry by direct interactions between the cel

111 Thus, molecular mimicry by HIV-1 Env that promotes the evasion

112 coding TMEV serves as an excellent model for molecular mimicry by inducing pathologic myelin-specific

113 We developed an infectious model of molecular mimicry by inserting a sequence encompassing t

114 ion of an essential host phosphatase through molecular mimicry by pathogens and diversification promo

115 xtracellular matrix, we investigated whether molecular mimicry by the GAS hyaluronic acid capsule mig

116 The results also suggest a mechanism (molecular mimicry) by which pathogenic aPL may be genera

117 Overall, these findings help clarify how molecular mimicry can drive self/nonself cross-reactivit

118 th preceding Campylobacter jejuni infection, molecular mimicry causes a cross-reactive antibody respo

119 scribed previously, provide evidence for the molecular mimicry concept.

120 -antigens during inflammatory responses, and molecular mimicry contribute to the initiation of autoan

121 A humoral immune response predicated on molecular mimicry could explain persistent or ongoing ne

122 an pain signaling, and provide an example of molecular mimicry driven by defensive selection pressure

123 ch dysbiosis might trigger arthritis include molecular mimicry, dysregulation of mucosal immunity, mi

124 haring antigenic epitopes with CNS antigens (molecular mimicry) elicits a virus-specific immune respo

125 ell responses, humoral fine specificity, and molecular mimicry evidence for differences between syste

126 d the need for regulatory devices to prevent molecular mimicry from progressing to autoimmune disease

127 This novel molecular mimicry function of Vpr might lead to its pote

128 In an example of molecular mimicry, globomycin appears to inhibit by acti

129 Our results illustrate two axes of molecular mimicry-gp350 versus C3d and CR2 versus EBV nA

130 Furthermore, because molecular mimicry has been postulated as a possible caus

131 Molecular mimicry has been proposed as a pathogenetic me

132 Molecular mimicry has been suggested to play a role in t

133 This may indicate that molecular mimicry has occurred, because several pathogen

134 Our results cast doubt on the molecular mimicry hypothesis as an explanation for the p

135 T cell cross-reactivity underpins the molecular mimicry hypothesis in which microbial peptides

136 The present report reevaluates the molecular mimicry hypothesis to explain HSK pathogenesis

137 One of these, the molecular mimicry hypothesis, postulates that myelin-rea

138 lines of evidence also failed to support the molecular mimicry hypothesis, such as the failure to aff

139 er jejuni, are discussed in the context of a molecular mimicry hypothesis.

140 me may influence the development of uveitis: molecular mimicry, imbalance of regulatory and effector

141 in pathway and a framework for understanding molecular mimicry in bacterial pathogenesis.

142 he literature on the concept and evidence of molecular mimicry in cancer is reviewed, covering the wh

143 report that gut microbial molecular mimicry in concert with gut microbes that enha

144 The data provide a mechanistic framework for molecular mimicry in Graves' disease, where early precur

145 These data provide strong support for molecular mimicry in HIV-1-immunologic thrombocytopenia

146 ism underpinning cross-kingdom signaling and molecular mimicry in mutualistic plant-microbe interacti

147 Consistent with the idea of molecular mimicry in protein interactions, RidL outcompe

148 The theme of molecular mimicry in streptococcal autoimmune sequelae i

149 Here, the current understanding of molecular mimicry in T cell-mediated tumour immunity and

150 two molecules and raises the possibility of molecular mimicry in the pathogenesis of Graves' disease

151 indings substantiate the hypothesis of viral molecular mimicry in the pathogenesis of MS and warrant

152 We have proposed a mechanism of molecular mimicry in which Abs against DENV nonstructura

153 of the function of the immune response and 'molecular mimicry' in the CB-3-induced autoimmune myocar

154 For each patient, we developed an 'IgE molecular-mimicry index' (IgE-MMI), calculated from IgE

155 r understanding of the mechanisms underlying molecular mimicry-induced CNS autoimmunity.

156 complete Freund's adjuvant, indicating that molecular mimicry-induced disease initiation requires vi

157 trains in patients with SSc, and evidence of molecular mimicry inducing autoimmune responses suggest

158 This provides structural evidence for molecular mimicry involving HLA molecules.

159 Molecular mimicry is a common mechanism used by many bac

160 Molecular mimicry is a possible explanation for autoimmu

161 Molecular mimicry is an evolutionary strategy adopted by

162 Molecular mimicry is characterized by an immune response

163 For our purpose, molecular mimicry is defined as similar structures share

164 Molecular mimicry is facilitated by a post-translational

165 Molecular mimicry is implicated in the pathogenesis of a

166 These findings also suggest that bacterial molecular mimicry is not involved in initiating disease.

167 ther autoimmune diseases, microbial mediated molecular mimicry is the most widely studied trigger tha

168 Molecular mimicry is the process by which T cells activa

169 Molecular mimicry is the process by which virus infectio

170 Mimicry of host protein structures, or 'molecular mimicry', is a common mechanism employed by vi

171 study represents the first example of direct molecular mimicry leading to clinically relevant fatal t

172 he immunogenicity of a synthetic peptide via molecular mimicry, leading to the inadvertent activation

173 GBS evolved to display CPS Sia as a form of molecular mimicry limiting the activation of an effectiv

174 Toward deciphering the structural basis of molecular mimicry, mAb 2D10 was isolated from a maturing

175 Molecular mimicry manifests antagonistically with respec

176 In a process called molecular mimicry, many bacterial pathogens decorate the

177 Our finding also supports the thesis that molecular mimicry may be implicated in the initiation of

178 Molecular mimicry may be important in breaking self-tole

179 This study documents that molecular mimicry may play a role in stability and organ

180 Autoimmunity based on molecular mimicry may play a role in the pathogenesis of

181 In this review, we consider how butyrate molecular mimicry may play out in the setting of mucosal

182 g that epitope spreading may occur through a molecular mimicry mechanism.

183 Recent studies have shown additional molecular mimicry mechanisms between early events in lup

184 findings contribute to the tracing of novel molecular mimicry mechanisms employed by pathogenic viru

185 ase antibody and RRV proteins indicates that molecular mimicry might activate humoral autoimmunity in

186 The molecular mimicry model proposes that the tip of domain

187 A commonly proposed model (the molecular mimicry model) used to explain TCR cross-react

188 Rather than the traditional molecular mimicry model, we propose that epitope spreadi

189 en EF-G and the ribosome are consistent with molecular mimicry models for EF-G function.

190 Molecular mimicry occurs when T cells specific for pepti

191 Tyr residues to binding as well as striking molecular mimicry of a maltose-binding protein substrate

192 Molecular mimicry of chemokine ligands has been describe

193 Molecular mimicry of cytokines and cytokine receptors is

194 effector of Legionella pneumophila exhibits molecular mimicry of eukaryotic F-box proteins and is es

195 sion of a bacterial tether, IncV, displaying molecular mimicry of eukaryotic FFAT motif cores.

196 ell-known gonococcal virulence mechanism-the molecular mimicry of host glycans.

197 receptors evolved as a response to pathogen molecular mimicry of host ligands for inhibitory recepto

198 d that HDMs modulate the immune response via molecular mimicry of host molecules.

199 Molecular mimicry of host proteins by pathogens can lead

200 tive immunization strategy that exploits the molecular mimicry of HS to generate antibodies against H

201 Molecular mimicry of human antigens related to RA was al

202 ty, including EBV nuclear antigen 1-mediated molecular mimicry of human autoantigens; EBV-mediated B

203 Molecular mimicry of NF-kappaB may be conserved because

204 Molecular mimicry of NF-kB may be conserved because othe

205 Cancer cell molecular mimicry of stem cells (SC) imbues neoplastic c

206 Molecular mimicry of TAC by peptides is an alternative a

207 gs shed light on the structural basis of the molecular mimicry of the chemokine function by a pathoge

208 nteraction surface is extensive and involves molecular mimicry of the DNA substrate.

209 The possible molecular mimicry of the Epstein-Barr virus (EBV) peptid

210 However, molecular mimicry of the lipooligosaccharide (LOS) of mo

211 inds with subnanomolar affinity to EphA2 via molecular mimicry of the receptor's cellular ligands, ep

212 e S. flexneri utilizes a remarkable level of molecular mimicry of the talin-vinculin interaction to a

213 Remarkably, this occurs through molecular mimicry of the vinculin-talin interaction that

214 such as C. trachomatis have evolved complex molecular mimicry of these eukaryotic features.

215 of TCR 11A5, providing proof of concept that molecular mimicry of viral and self-epitopes can drive T

216 e proteins likely associated with microbial "molecular mimicry" of host characteristics and involved

217 P evolved independently to converge, through molecular mimicry, on a common helicase-opening mechanis

218 lf Ags may represent a mechanism by which Ag molecular mimicry operates.

219 he allogeneic molecule itself either through molecular mimicry or by novel pMHC binding modes.

220 cination, pointing towards processes such as molecular mimicry or bystander activation as crucial for

221 tion of hypocretin producing neurons include molecular mimicry or bystander activation, and are likel

222 are not paraneoplastic, and are triggered by molecular mimicry or unknown mechanisms.

223 These observations suggest that although molecular mimicry plays a pivotal role in initially trig

224 unodominant epitope of tax and suggests that molecular mimicry plays a role in the pathogenesis of HA

225 for advancing our understanding of the role molecular mimicry plays in the induction of autoimmunity

226 he role that mycoplasma adhesins may play in molecular mimicry, postinfectious autoimmunity, and immu

227 Molecular mimicry refers to structural homologies betwee

228 nd specificity, but the structural basis for molecular mimicry remains unclear.

229 Molecular mimicry, resulting from structural similaritie

230 complex, our study unravels a sophisticated molecular mimicry strategy that is used by L. pneumophil

231 ted by distinct immune components, including molecular mimicry, T-cell receptor affinity, and, import

232 cts of autoimmunity: the mechanism of T cell molecular mimicry; T-->B epitope spreading, as a basis f

233 of supramolecular complexes, and the use of molecular mimicry, target host transcription factors tha

234 cious "pseudonormal" phenotype, may enable a molecular mimicry that allows metastasizing tumor cells

235 gical processes and provides a blueprint for molecular mimicry that drives drug discovery.

236 Molecular mimicry, the sharing of epitopes among self an

237 The molecular mimicry theory has become a dominant paradigm

238 The molecular-mimicry theory proposes that immune crossreact

239 n-Barr virus triggers multiple sclerosis via molecular mimicry to a protein known as GlialCAM.

240 ella flexneri and Listeria monocytogenes use molecular mimicry to create their own actin-based motors

241 neumoniae disables neutrophils by exploiting molecular mimicry to degrade platelet-activating factor

242 By applying the concept of molecular mimicry to identify potential CD8 T-cell epito

243 To study the potential of virus-induced molecular mimicry to initiate autoimmune demyelination,

244 ype 1 diabetes but do not support a role for molecular mimicry to insulin in the pathogenesis of this

245 hat autoimmunity to some RNPs may arise from molecular mimicry to microbial orthologs.

246 obacteria, small non-coding RNAs (sRNAs) use molecular mimicry to sequester multiple CsrA dimers away

247 the effects of direct infection by means of molecular mimicry to tissue autoantigens.

248 e historic background of clonal deletion and molecular mimicry, two major pillars underlying our pres

249 distinct bacterial peptides demonstrate that molecular mimicry underpins cross-reactivity toward the

250 Ternary structures showed that induced-fit molecular mimicry underpins TRAV27/TRBV19(+)TCR specific

251 We propose that rather than simple molecular mimicry, unpredictable arrays of common and di

252 immune dysregulation, chronic inflammation, molecular mimicry, viral persistence and emerging therap

253 es revealed that in a two-antibody cocktail, molecular mimicry was a major feature of mAb-GP interact

254 Molecular mimicry was sought by screening a phage peptid

255 y processes underlying the phenomenon of Sia molecular mimicry, we performed phylogenomic analyses of

256 As a model for molecular mimicry, we studied patients with human T-lymp

257 Thermodynamic contributions of this molecular mimicry were investigated using substitutions

258 If molecular mimicry were not common, protective adaptive i

259 immunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes, proce

260 gger lupus through structural and functional molecular mimicry, whereas the accumulation of ERV-deriv

261 isation in the immune system, based on viral molecular mimicry, whereby immune cells attack the self,

262 host protein-derived antigens in the CNS via molecular mimicry, whereupon they produce high levels of

263 S1 can induce Plg cross-reactive Abs through molecular mimicry, which can enhance Plg activation and

264 , B cells may trigger autoimmune disease via molecular mimicry, which occurs when a single B-cell rec

265 where immune reactivity toward EBNA1 through molecular mimicry with ANO2 contributes to the etiopatho

266 The etiology of PBC is unknown, although molecular mimicry with bacterial PDC has been proposed.

267 EBV antigens exhibit structural molecular mimicry with common SLE antigens and functiona

268 icry with common SLE antigens and functional molecular mimicry with critical immune-regulatory compon

269 ell responses, humoral fine specificity, and molecular mimicry with EBV, further supporting potential

270 re envelope 1 can induce thrombocytopenia by molecular mimicry with GPIIIa49-66.

271 identify a functional epitope that displays molecular mimicry with human erythropoietin (EPO) and pr

272 DL immunoglobulin M (IgM) antibodies, due to molecular mimicry with oxLDL.

273 al foreign antigen for anti-Ro autoimmunity, molecular mimicry with regard to La and CCHB, as well as

274 re of one such cationic molecule suggested a molecular mimicry with spermine, a ubiquitous endogenous

275 Such antibodies are induced via molecular mimicry with the serum protein beta2-glycoprot

276 m viral and bacterial microorganisms showing molecular mimicry with tumour-cell-expressed antigens wa