ライフサイエンスコーパス: molecular motor

1 A, an unconventional single-headed class XIV molecular motor.

2 TolA, which is part of the conserved Tol-Pal molecular motor.

3 e of TEM requires microtubules and a kinesin molecular motor.

4 using a transiently assembled phage-encoded molecular motor.

5 transport of capsids requires the kinesin-1 molecular motor.

6 re capable of describing the function of any molecular motor.

7 ansfer between the porphyrin linkers and the molecular motor.

8 ms, namely, a partially hidden network and a molecular motor.

9 ations with elastic dynamic microtubules and molecular motors.

10 or active cargo transport and positioning by molecular motors.

11 lity, or regulate the activity of associated molecular motors.

12 aments, called flagella, that are powered by molecular motors.

13 cturing of dynamic nanodevices using protein molecular motors.

14 disruption of microtubules and inhibition of molecular motors.

15 ey still function properly as unidirectional molecular motors.

16 omponents and internal force generation from molecular motors.

17 ssembly of bipolar spindle in the absence of molecular motors.

18 of a series of third-generation light-driven molecular motors.

19 ensure mRNA silencing and provide a link to molecular motors.

20 cation, but also preserve the bioactivity of molecular motors.

21 biomolecular motors with current artificial molecular motors.

22 for optical-trapping-based investigations of molecular motors.

23 these cargoes with microtubules mediated by molecular motors.

24 n by processive microtubule- and actin-based molecular motors.

25 rocesses are directional movements driven by molecular motors.

26 and are mostly driven by different forms of molecular motors.

27 provides the tracks for transport driven by molecular motors.

28 will be essential in designing future rotary molecular motors.

29 nsport of cargo is accomplished by groups of molecular motors.

30 e structural support and serve as tracks for molecular motors.

31 nspired the design of innumerable artificial molecular motors.

32 from stochasticity in the forces from these molecular motors.

33 rotational cycle of overcrowded-alkene-based molecular motors.

34 nterpreted, with a focus on mechanosensitive molecular motors.

35 relies on active transport of organelles by molecular motors.

36 ch is largely brought about by intracellular molecular motors.

37 the surface of a liquid crystal by synthetic molecular motors.

38 is of adenosine triphosphate (ATP) by myosin molecular motors.

39 ular transport by teams of myosin Va (MyoVa) molecular motors.

40 lagen and actomyosin networks prestressed by molecular motors.

41 erplay between intrinsic forces generated by molecular motors(1-3), extrinsic forces exerted by adjac

42 lls [2], voltage-dependent ion channels [3], molecular motors [4-7], and synaptic transmission [8-11]

43 sociable cytoplasmic targeting components, a molecular motor, a protein-conducting membrane pore, and

44 on of the rotational position for the A-type molecular motor A3B3DF, from the Methanosarcina mazei Go

45 ort and may reveal common mechanisms for how molecular motors accurately deposit cargoes at the corre

46 that there are general rules for functional molecular motors across the different families.

47 Molecular motors actively step along microtubules to shu

48 Molecular motor activity is driven by a heterotrimeric c

49 anical forces on the nuclear surface through molecular motor activity, we conclude that the intermedi

50 , filament assembly, and force generation by molecular motors, all of which occur much faster [1-4].

51 through regulated active transport driven by molecular motors along microtubule tracks.

52 Drosophila nonmuscle myosin-2 is a bona fide molecular motor and establish an important link between

53 concentrations; myotropes, which affect the molecular motor and scaffolding; and mitotropes, which i

54 ion requires cyclic interactions between the molecular motor and the adhesion proteins of the outer m

55 ives many essential processes in vivo, using molecular motors and actin assembly as force generators.

56 be shifted by altering the number of active molecular motors and clutches.

57 We designed molecular motors and complementary experimental protocol

58 es a properly regulated transport network of molecular motors and cytoskeletal tracks.

59 rized in the context of the myosin family of molecular motors and is emerging as a versatile structur

60 Roop Mallik studies how molecular motors and lipids interact to drive intracellu

61 nanometer-precision, e.g., for the study of molecular motors and membrane processes, it has been sel

62 The collective activity of several molecular motors and other active processes generate lar

63 More recently, molecular motors and switches that can change their conf

64 onal rotation of [2]- and [3]catenane rotary molecular motors and the transport of substrates away fr

65 h can be more indicative of the work done by molecular motors and their dynamic binding status.

66 he design principles of a number of types of molecular motors and their interactions with their track

67 given of the principal designs of artificial molecular motors and their modes of operation.

68 ural intermediates in the reaction cycles of molecular motors and to understand how substeps in energ

69 These organelles can also recruit molecular motors and transport their cargo virions along

70 amentous network under stresses generated by molecular motors, and deeply couples mechanics and chemi

71 f systems such as photoresponsive materials, molecular motors, and photoactivated drugs.

72 that contains APP, the secretase machinery, molecular motors, and previously proposed and new reside

73 eleased EVs, including RNA-binding proteins, molecular motors, and proteins regulating secretory path

74 h defined functionality, such as organelles, molecular motors, and transmembrane pumps.

75 field of photo- and redox-driven artificial molecular motors, and we provide a comprehensive review

76 have realized and investigated an artificial molecular motor applying scanning tunneling microscopy (

77 Network dynamics is driven by molecular motors applying force onto the networks and th

78 Molecular motors are at the heart of cellular machinery,

79 Teams of processive molecular motors are critical for intracellular transpor

80 Molecular motors are diverse enzymes that transduce chem

81 The linear and rotary molecular motors are driven by aliquots of a chemical fu

82 Molecular motors are essential to the living, generating

83 The main classes of light- and redox-driven molecular motors are illustrated, with a particular focu

84 Molecular motors are known to be responsible for cytoske

85 be generally applicable to studies in which molecular motors are labeled with cargos that are artifi

86 However, although biological molecular motors are powered by chemical gradients or th

87 Molecular motors are responsible for numerous cellular p

88 m a synthetic perspective, the most advanced molecular motors are rotators that are activated by ligh

89 dimension typically being less than 100 nm, molecular motors are significantly below the optical-res

90 ctional units in biology, such as enzymes or molecular motors, are composed of several subunits that

91 he mitochondrial F-ATP synthase is a complex molecular motor arranged in V-shaped dimers that is resp

92 The mechanisms by which molecular motors associate with specific cargo is a cent

93 The strategic placement of a molecular motor at the center of the particle further su

94 Presented are molecular motor attachments to surfaces, their insertion

95 sotropic fluid, composed of microtubules and molecular motors, autonomously flows through meter-long

96 The enantiomeric homogeneity of light-driven molecular motors based on overcrowded alkenes is crucial

97 Symmetric molecular motors based on two overcrowded alkenes with a

98 Neuronal connectivity relies on molecular motor-based axonal transport of diverse cargoe

99 mpact microtubule-based processes, including molecular motor-based intracellular transport.

100 hese interactions critical to the success of molecular motor-based nanodevices.

101 it provides a mechanically stable track for molecular motor-based transport and produces forces that

102 ules exist, but whether these defects impact molecular motor-based transport remains unknown.

103 Recently, a molecular-motor-based mechanism for axonal length sensin

104 enes are among the most promising artificial molecular motors because of their ability to undergo rep

105 antages over biological chemically activated molecular motors because one can direct precise spatiote

106 used in biology and nanotechnology to study molecular motors, biopolymers and nanostructures, its ap

107 ynein and kinesin are both microtubule-based molecular motors but are structurally and evolutionarily

108 ted along microtubules by kinesin and dynein molecular motors, but how transport is regulated is not

109 of MTs that are cross-linked and powered by molecular motors by iteratively solving a set of force-b

110 nsequently, the rotational behavior of these molecular motors can be dynamically controlled with chem

111 duction components, epigenetic machinery and molecular motors can be engineered and introduced into p

112 The mechanical work produced by arrays of molecular motors can be used to induce a macroscopic eff

113 that Saccharomyces cerevisiae condensin is a molecular motor capable of adenosine triphosphate hydrol

114 We find that two actin-dependent molecular motors, class 1 myosins myosin 1e and myosin 1

115 Microtubules and molecular motors connect the poles to kinetochores, spec

116 Synthetic molecular motors continue to attract great interest due

117 le location, net directional rotation of the molecular motor continues for as long as unreacted fuel

118 anization of filamentous actin and myosin II molecular motor contractility is known to modify the mec

119 d, we examined the group function of a major molecular motor, conventional kinesin, when transporting

120 Molecular motors couple chemical transitions to conforma

121 It comprises two molecular motors coupled together by a central and a per

122 w cell shape, cytoskeletal organization, and molecular motors cross-talk to regulate initial spindle

123 t from the axon to the soma is driven by the molecular motor cytoplasmic dynein, yet it remains uncle

124 This process occurs through the action of molecular motors, cytoskeletal networks, and the nucleus

125 ures differs substantially in T. gondii, the molecular motor dependence of DG trafficking is far from

126 Molecular motors drive cytoskeletal rearrangements to ch

127 y both active stresses and polymer turnover: Molecular motors drive deformations required for cell mo

128 Molecular motors drive TFP extension and retraction, but

129 articular interest are unidirectional rotary molecular motors driven by chemical fuel or light.

130 ntracellular stiffness and power output from molecular motor-driven fluctuations in cells overexpress

131 combine theory and experiments to show that molecular motor-driven forces shape the structure throug

132 A sequences are aligned via an ATP-dependent molecular motor-driven mechanism.

133 xample, messenger RNA (mRNA) localization by molecular motor-driven transport is crucial for cell pol

134 usive, we devise a theoretical model for the molecular-motor-driven motion of the MT cytoskeleton con

135 sis of double-stranded DNA bacteriophages, a molecular motor drives the viral genome inside a protein

136 The molecular motor dynein concentrates at the kinetochore r

137 Mutations in components of the molecular motor dynein/dynactin lead to neurodegenerativ

138 Molecular motors embedded within collections of actin an

139 Processive molecular motors enable cargo transportation by assembli

140 cellular cargo transport relies on myosin Va molecular motor ensembles to travel along the cell's thr

141 osin Va (myoVa) is a processive, actin-based molecular motor essential for intracellular cargo transp

142 Unconventional myosin 15 is a molecular motor expressed in inner ear hair cells that t

143 Cytoskeletal filaments and molecular motors facilitate the micron-scale force gener

144 Herein we report three new second-generation molecular motors featuring a phosphorus center in the lo

145 of a series of light-driven third-generation molecular motors featuring various structural modificati

146 s, viral capsids depend on microtubule-based molecular motors for efficient and fast transport.

147 lobal extension are simultaneously driven by molecular motor forces and should thus be regulated by t

148 sitating the need for intrinsic control over molecular motor function.

149 Bundles of cytoskeletal filaments and molecular motors generate motion in living cells, and ha

150 lagellar transport (IFT) employing kinesin-2 molecular motors has been implicated in trafficking of p

151 epth analysis of mechanochemical coupling in molecular motors has made the development of artificiall

152 Although synthetic molecular motors have also found widespread application

153 Molecular motors have evolved to transduce chemical ener

154 ctions with the cytoskeleton exists, but the molecular motors have received no attention as anestheti

155 es that explore the behavior of ensembles of molecular motors have used nonphysiological cargoes such

156 During mitosis, molecular motors hydrolyze ATP to generate sliding force

157 e well-defined energy landscapes in studying molecular motors in general and myosin in particular.

158 pen new vistas to the transport phenomena by molecular motors in general.

159 ging ATPase, and are among the most powerful molecular motors in nature.

160 ese results emphasize the different roles of molecular motors in particular mechanisms.

161 and assessing the utility of novel synthetic molecular motors in the future.

162 eractions between GTPase, cytoskeletons, and molecular motors initiate spontaneous polarization in ba

163 d geometry changes of a hemithioindigo based molecular motor into catalytic efficiency of a chemical

164 Dyneins are important molecular motors involved in many essential biological p

165 ledge on the key RNA-binding protein and the molecular motors involved, it is unclear how mRNAs are c

166 Hanging out of the back of the Kif14 molecular motor is an intrinsically disordered domain th

167 y the switching capacity of a hemithioindigo molecular motor is established in a multicomponent chemi

168 but how these units connect to function as a molecular motor is mysterious.

169 The myosin-V family of molecular motors is known to be under sophisticated regu

170 e now find that the budding yeast kinesin-14 molecular motor Kar3-Cik1 can efficiently align spindle

171 c domain that were essential for binding the molecular motor kinesin-1.

172 s-end tracker EB1 and the minus-end-directed molecular motor Kinesin-14 is sufficient to promote para

173 The molecular motors kinesin and dynein drive bidirectional

174 packaging motors are among the most powerful molecular motors known.

175 del is that fluctuations in the transport of molecular motors lead to a reduction in the reliability

176 s coordination with the activity of specific molecular motors like myosin.

177 erface; and of the structure and function of molecular motors, making the study of these interactions

178 ween Brownian diffusion in the cytoplasm and molecular motor-mediated active transport.

179 es are transported to the plasma membrane by molecular motors moving on their respective cytoskeletal

180 Mutations of the molecular motor myosin 15 stunt stereocilia growth and c

181 d by expression of the rare isoform A of the molecular motor myosin IC, however the function of this

182 st understood of these systems, which is the molecular motor myosin that moves on tracks of filamento

183 The molecular motor myosin V transports cargo by stepping on

184 mponent the thick filament, comprised of the molecular motor myosin.

185 is issue, Lelli et al. reveal that a pair of molecular motors, myosin IIIa and myosin IIIb, is involv

186 We also find that LSP1 binds to the class I molecular motor myosin1e.

187 ists have developed artificial prototypes of molecular motors, namely, multicomponent synthetic speci

188 e conventional myosin-II or other processive molecular motors, Ncd requires two ATP turnovers rather

189 tated by contractile forces generated by the molecular motor, non-muscle myosin II (NMII).

190 ed by the cytoskeletal protein actin and the molecular motor nonmuscle myosin II.

191 hat they neither depend on microtubule-based molecular motors nor pressure generated by myosin-II.

192 as a simple and powerful tool to control the molecular motor of muscle, myosin.

193 pathogenic missense variants in myosin, the molecular motor of the sarcomere, are clustered in resid

194 The role of rotational molecular motors of the ATP synthase class is integral t

195 The two opposed rotary molecular motors of the F0F1-ATP synthase work together

196 ts into uncovering how force is generated by molecular motors.Omecamtiv mecarbil (OM) is a cardiac my

197 ical pulling forces exerted in particular by molecular motors on MTs and controlled by external cues

198 Upon physical adsorption of the molecular motors onto lipid bilayers and subsequent acti

199 The speed at which a molecular motor operates is critically important for the

200 n of individual molecular components such as molecular motors or switches into larger meta-functional

201 Biological molecular motors (or biomolecular motors for short) are

202 We observed unidirectional movements of the molecular motors over 3 microm with a translocation velo

203 rphyrin in the MOFs upon introduction of the molecular motor pillars confirms efficient triplet-to-tr

204 We suggest that the molecular motor plays a key role in determining the fina

205 ion by a voltage-dependent activation of the molecular motor, prestin (SLC26a5), in the cell's latera

206 hat the visible light-driven rotation of the molecular motor proceeds in the solid state at rates sim

207 Molecular motors produce force when they interact with t

208 At the subcellular level, molecular motors prompt fluidization and actively stiffe

209 fashion using a large number of independent, molecular-motor-propelled agents then solves the mathema

210 The movement of a molecular motor protein along a cytoskeletal track requi

211 e 5 (AdV5) capsid protein hexon recruits the molecular motor protein cytoplasmic dynein in a pH-depen

212 rete molecular photodynamic steps, action of molecular motors, protein folding, diffusion, etc. down

213 The reliability by which molecular motor proteins convert undirected energy input

214 g most members of the kinesin superfamily of molecular motor proteins that is critical for kinesin's

215 osite orientation are spatially separated by molecular motor proteins.

216 atable forces imposed on the microtubules by molecular motor proteins.

217 Kinesin-14s are conserved molecular motors required for high-fidelity chromosome s

218 Myosin is a molecular motor responsible for biological motions such

219 Kinesin-1 is a molecular motor responsible for cargo transport along mi

220 Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo

221 Myosin Va is an actin-based molecular motor responsible for transport and positionin

222 Furthermore, the new molecular motor retains unidirectional rotation while sh

223 Synthetic light-driven rotary molecular motors show complicated structural dynamics du

224 dynamic interplay between the cytoskeleton, molecular motors, signaling molecules, and membranes.

225 Applications of this analysis include molecular-motor stepping, fluorophore bleaching, electro

226 iven rotation of an overcrowded alkene-based molecular motor strut in a dual-function metal-organic f

227 Molecular motors such as kinesin and dynein use the ener

228 Molecular motors such as kinesin-1 drive active, long-ra

229 For molecular motors such as myosin-V, the ratio of forward

230 few mechanistic details are known about how molecular motors, such as myosin XI, associate with thei

231 A new unidirectional light-driven molecular motor suitable for host-guest surface inclusio

232 n of H129 particle movement by inhibitors of molecular motors support that kinesin-1 contributes to t

233 Finally, we discuss how these molecular motors tailor their operation-often through re

234 The field of artificial molecular motors takes inspiration from these tiny but p

235 n networks is nonmuscle myosin II (NMMII), a molecular motor that assembles into ensembles that bind,

236 F1-ATPase is a highly efficient molecular motor that can synthesize ATP driven by a mech

237 Cytoplasmic dynein-1 is a molecular motor that drives nearly all minus-end-directe

238 FtsK is a powerful molecular motor that functions in cell division, co-ordi

239 Gyrase is a molecular motor that harnesses the free energy of ATP hy

240 , and cytoplasmic dynein-1 is an established molecular motor that is critical for neurogenesis and ho

241 Myosin 10 is an actin-based molecular motor that localizes to the tips of filopodia

242 Mutations in genes encoding myosin, the molecular motor that powers cardiac muscle contraction,

243 on-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoske

244 utic target, nonmuscle myosin IIB (NMIIB), a molecular motor that supports memory by directly driving

245 sviruses, this is accomplished by a powerful molecular motor that translocates the viral DNA into a p

246 Myosin 5a is a dual-headed molecular motor that transports cargo along actin filame

247 Myosin-5B is a ubiquitous molecular motor that transports cargo vesicles of the en

248 Kinesin-1 is an ATP-driven molecular motor that transports cellular cargo along mic

249 FoF1 is a membrane-bound molecular motor that uses proton-motive force (PMF) to d

250 rs of the myosin superfamily are actin-based molecular motors that are indispensable for cellular hom

251 of passive diffusion and active transport by molecular motors that ballistically move along a network

252 Intracellular transport is mediated by molecular motors that bind cargo to be transported along

253 process is mediated by kinesins and dyneins, molecular motors that bind to cargoes and translocate on

254 A variety of molecular motors that can move on tracks within cells ha

255 Helicases are molecular motors that couple the energy of ATP hydrolysi

256 Myosins are molecular motors that generate force to power a wide arr

257 of which depend crucially on the activity of molecular motors that generate forces.

258 Many viruses use molecular motors that generate large forces to package D

259 emically-driven artificial rotary and linear molecular motors that operate through a fundamentally di

260 Myosins are molecular motors that power diverse cellular processes,

261 The novel concept of amphiphilic molecular motors that self-assemble into responsive supr

262 Molecular motors that translocate DNA are ubiquitous in

263 Myosins are molecular motors that use a conserved ATPase cycle to ge

264 orce-induced changes in contractility of the molecular motor, the beta-cardiac myosin (betaCM).

265 otubule-severing enzymes and the movement of molecular motors through their boundaries.

266 In neurons, mitochondria are transported by molecular motors throughout the cell to form and maintai

267 phages and herpesviruses, utilize a powerful molecular motor to package their genomic DNA into a pref

268 essive exopeptidase digestion, or by using a molecular motor to pull proteins through a tunnel juncti

269 Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to synapses, bu

270 a set of protein assemblies that function as molecular motors to couple the energy of nucleoside trip

271 that have been used to re-engineer existing molecular motors to have, for instance, altered speed, p

272 o-state model adapted from studies of linear molecular motors to identify key features of this motor.

273 Many viruses utilize molecular motors to package their genomes into preformed

274 Double-stranded DNA viruses use ATP-powered molecular motors to package their genomic DNA.

275 Cellular function requires molecular motors to transport cargoes to their correct i

276 MglA directs molecular motors to transport the bacterial actin homolo

277 tified myosin-1E (MYO1E), an actin-dependent molecular motor, to interact directly with the FAK FERM-

278 osis requires the interconnected activity of molecular motors trafficking vesicular cargo within a dy

279 allenge our fundamental understanding of how molecular motors transduce energy.

280 Molecular motors translocate along cytoskeletal filament

281 Molecular motors transport organelles to their proper de

282 cytokinesis precursor nodes that include the molecular motor type-II myosin Myo2 and the actin assemb

283 uncover a surprising role of the anterograde molecular motor UNC-104/KIF1A as a key regulator of neur

284 The dynamic function of the molecular motor units inside the supramolecular assembli

285 Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a s

286 ransport is that organelles directly recruit molecular motors via cargo-specific adaptors.

287 To this end, a new molecular motor was designed, and the isomerization proc

288 The molecular motor was introduced in the framework using th

289 id racemization, a new class of light-driven molecular motors was designed, synthesized, and studied.

290 E STATEMENT Here, we establish that KIFC1, a molecular motor well characterized in mitosis, is robust

291 Monolayers of fluorinated light-driven molecular motors were synthesized and immobilized on gol

292 in photosensitizer and a bispyridine-derived molecular motor, were used to construct the framework ca

293 model provides an example of a new class of molecular motor where large conformational fluctuations

294 res the activity of myosins, actin-dependent molecular motors, which perform a variety of functions a

295 The bacterial flagellum is a remarkable molecular motor, whose primary function in bacteria is t

296 nticipate that autonomous chemically fuelled molecular motors will find application as engines in mol

297 Here the excited-state dynamics of a molecular motor with electron donor and acceptor substit

298 A third-generation molecular motor with the potential to be the fastest bas

299 A series of first-generation light-driven molecular motors with rigid substituents of varying leng

300 imizing the efficiency of operation of these molecular motors without modifying their overall rotatio