ライフサイエンスコーパス: molecular probe

1 p with the sensing region (e.g., immobilized molecular probes).

2 ondrial specific dye used was rhodamine 800 (Molecular Probes).

3 ntravitreal injection of an oxygen-sensitive molecular probe.

4 n intravenously injected palladium porphyrin molecular probe.

5 and induced RONS detected by a general RONS molecular probe.

6 pool sizes using the photoacid pyranine as a molecular probe.

7 ions, and biofilm formation, and to use as a molecular probe.

8 their cellular function or be the basis for molecular probes.

9 ized by (19)F NMR and evaluated as (19)F NMR molecular probes.

10 H was not detected when using *OH scavenging molecular probes.

11 al nanoplatform for developing photoacoustic molecular probes.

12 , due to low availability of target-specific molecular probes.

13 and synthesized fluorinated bromopyronins as molecular probes.

14 te-specific incorporation of any one of many molecular probes.

15 y preventing brain delivery of most targeted molecular probes.

16 proteins that are useful as therapeutics or molecular probes.

17 hampered by the lack of chromosome-specific molecular probes.

18 ncreasingly sensitive, selective, and robust molecular probes.

19 distinguishing between bound verses unbound molecular probes.

20 avital catheter-based imaging of fluorescent molecular probes.

21 l in vivo applications using NIR polymethine molecular probes.

22 target cells for the generation of effective molecular probes.

23 d characterization of phosphonium cations as molecular probes.

24 imaged by use of specific activity-dependent molecular probes.

25 e and eliminates any requirement for dyes or molecular probes.

26 alidating their use as therapeutic agents or molecular probes.

27 ursor protein (APP) and Notch by using small molecular probes.

28 signed to encourage the development of small molecular probes.

29 ures as customizable substitutes for organic molecular probes.

30 ude a more complete set of immunological and molecular probes.

31 floxacin (CIPRO), were chosen as nonresonant molecular probes.

32 by many researchers for developing reactive molecular probes.

33 te for developing robust and informative new molecular probes.

34 The structurally optimized molecular probe 3 responds exclusively to microM-level c

35 A molecular probe, 3-amino-2,2,5,5,-tetramethy-1-pyrrolydi

36 A fluorescent molecular probe, 6-carboxy fluorescein, was used in conj

37 as measured using a profluorescent nitroxide molecular probe 9-(1,1,3,3-tetramethylisoindolin-2-yloxy

38 n cleaved site-specifically by using a small molecular probe, a bulky metallointercalator, Rhchrysi o

39 Here we report the synthesis of fluorescent molecular probes able to unambiguously detect ozone in b

40 sment, insensitive to nonspecific sources of molecular probe accumulation and contrast, is presented

41 We used a molecular probe activated by protease cleavage to image

42 ombined with fluorescence imaging of various molecular probes, activity-dependent cellular processes

43 owever, unspecific antigen recognition, poor molecular probe adsorption and the need for sample dilut

44 the cross-linked interactions we observed as molecular probes, allowing quantification of conformatio

45 ections of replication-defective viruses and molecular probes allows the genetic analysis of essentia

46 Using intrinsic tryptophan as a molecular probe and from mutation studies, we ascertaine

47 stant to deiodination in vivo, both as small molecular probes and as antibody conjugates.

48 which have proven their potential as useful molecular probes and as next-generation therapeutics.

49 lanized humic materialas can be seen as both molecular probes and as potent candidate materials for s

50 d complexes allow a rational design of novel molecular probes and drugs.

51 recognition in muro, and that the access of molecular probes and enzymes to xylan epitopes/ligands a

52 Prompted by the urgent need for new molecular probes and inhibitors to understand LSD1/CoRES

53 This assay consumes only attomoles of molecular probes and is able to quantitatively detect su

54 s-sectional multimodal imaging incorporating molecular probes and other novel noninvasive techniques

55 by the relatively small number of pertinent molecular probes and the limited physicochemical propert

56 The use of molecular probes and the results of kinetic studies supp

57 targets, thereby providing a rich source of molecular probes and therapeutic leads.

58 lung preparations incorporating fluorescent molecular probes and transgenic reporter mice.

59 liant green and crystal violet dyes were the molecular probes, and the experiments were carried out o

60 ma system by facilitating development of new molecular probes, and the linkage map will allow compara

61 ovides a mechanistic understanding of drugs, molecular probes, and their biologic targets.

62 Molecular probes are currently being developed not only

63 A few of the recent reports reveal that such molecular probes are even capable of quantifying abnorma

64 s review, recent examples of lesion-specific molecular probes are surveyed; their specificities of in

65 These molecular probes are validated via multi-scale imaging,

66 idine orange and Lysotracker Red [Invitrogen-Molecular Probes]), autophagic vacuole content (MDC), SA

67 Molecular probes available for infection imaging have un

68 will dramatically increase the repertoire of molecular probes available to determine the developmenta

69 This is followed by a survey on (a) molecular probes, (b) nanomaterials, and (c) bulk materi

70 We have applied a fluorophore-labeled molecular probe based on a high-affinity platelet-derive

71 we report a new, to our knowledge, class of molecular probes based on dye-conjugated dendrimers for

72 l sensing strategy: electrochemically active molecular probes based on peptide nucleic acid (PNA) sca

73 Fluorescent molecular probes based on phosphonate-functionalized por

74 We chose to design new molecular probes based on the structure of 2-(1-(6-((2-[

75 drorhodamine 6G (DHR-6G) was selected as the molecular probe because it is sensitive to typical smoke

76 of(18)F-FDG, as well as the addition of new molecular probes beyond(18)F-FDG, the future holds signi

77 retion and reduced lumenal flux of different molecular probes (bovine serum albumin, alexa350, and de

78 lf-assembly of polyelectrolytes to which the molecular probes can be bound covalently.

79 ndicate that such small technetium-99m-based molecular probes can be developed as in vivo diagnostic

80 oxide, making this system the first discrete molecular probe capable of detecting HNO over NO under p

81 ogression and poor survival, suggesting that molecular probes capable of assaying TSPO levels may hav

82 Molecular probes capable of detecting colorectal cancer

83 erein we report the synthesis of a series of molecular probes capable of detection of tau protein dep

84 rs, we report the discovery of peptide-based molecular probes capable of selectively discriminating F

85 ,6-diaminido-2-phenylindole dihydrochloride (Molecular Probes, Carlsband, CA) revealed a relative uni

86 that a dualsteric design principle, that is, molecular probes, carrying two pharmacophores to simulta

87 didates and identified a novel, well-behaved molecular probe chemotype that specifically targets the

88 e analysis (DBTA), involves the perfusion of molecular probe-coated microspheres over tissues.

89 HER2-specific molecular probes, combined with modern imaging technique

90 y allows for the observation of tagged small molecular probes containing peptides and microRNAs.

91 upon binding of the antibody on the grafted molecular probe; conversely, when diclofenac is present

92 patible, viscosity-responsive, small organic molecular probe, Coupa, to monitor the interaction of mi

93 ide GRDSPK with a near-infrared carbocyanine molecular probe (Cypate) yielded a previously undescribe

94 A novel aptamer-based molecular probe design employing intramolecular signal t

95 covalently labeled with a hydroxamate-based molecular probe designated AspR1, which was developed fo

96 t of the luciferase construct as a sensitive molecular probe, detecting a specific DNA target sequenc

97 Three main strategies used in molecular probe development for H2S detection include az

98 to explore novel techniques for accelerating molecular probe development.

99 The first one is a molecular probe, diclofenac, coupled with an arylamine o

100 Molecular probes directed to structural elements of thes

101 n be fully realized only when novel types of molecular probes distinguishable in the Raman spectrosco

102 ly encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor

103 488, Oregon Green 488, and Oregon Green 514 (Molecular Probes (Eugene, OR)) are compared when conjuga

104 as assessed by using Sytox Green (Invitrogen-Molecular Probes, Eugene, OR) a nucleic acid dye uptake

105 intracellular injection with Lucifer yellow (Molecular Probes, Eugene, OR) and neurobiotin at E15.5,

106 eal permeability to AlexaFluor dextran (AFD; Molecular Probes, Eugene, OR) was measured by a fluorome

107 led with aminostilbamidine methanesulfonate (Molecular Probes, Eugene, OR), and loss of fluorescently

108 ondrial content (Mitotracker Red; Invitrogen-Molecular Probes, Eugene, OR), lysosomal content (acridi

109 amber and the proliferation assays (CyQUANT; Molecular Probes, Eugene, OR), respectively.

110 uorescent dyes (SYTOX Orange and SYTO Green; Molecular Probes, Eugene, OR), which differentiate betwe

111 rescent dye, LysoSensor Yellow-Blue DND 160 (Molecular Probes, Eugene, OR), which localizes to highly

112 with the nuclear dye SYTOX Green (Invitrogen-Molecular Probes, Eugene, OR).

113 Quenching of molecular probe fluorescence is achieved through unique

114 and interactions without any disturbances by molecular probes, fluorescent labels, or immobilization

115 (18)F-FB-NAPamide is a promising molecular probe for alpha-MSH receptor-positive melanoma

116 Using lumogallion as a direct-fluorescent molecular probe for aluminium, complemented with transmi

117 ell line, using lumogallion as a fluorescent molecular probe for aluminium.

118 While the (5F)LOH acts as a molecular probe for CN(-), (2F)LOH, (1F)LOH, and (0F)LOH

119 results suggest that PatA will be a valuable molecular probe for future studies of eukaryotic transla

120 s, behaves as a highly selective chromogenic molecular probe for hydrogenpyrophosphate anion in a com

121 ings, acts as a highly selective fluorescent molecular probe for hydrogenpyrophosphate anion in eithe

122 Thus, the mpo gene should provide a useful molecular probe for identifying zebrafish mutants with d

123 synthesis and evaluation of (18)F-FTPP as a molecular probe for imaging mitochondrial dysfunction.

124 elop and evaluate 99mTc-duramycin as a novel molecular probe for imaging PtdE.

125 Our study identifies SPI as a novel molecular probe for interrogating Stat3 signaling and th

126 ld therefore be considered as an appropriate molecular probe for NTS1 imaging by PET.

127 etallopeptide (18)F-FB-RMSH-1 is a promising molecular probe for PET of MC1R-positive tumors.

128 It is a strong candidate as a molecular probe for PtdE imaging and warrants further de

129 olecule was further evaluated as a potential molecular probe for small-animal PET HER2 imaging in a S

130 ng radiopeptide was evaluated as a potential molecular probe for small-animal PET of melanoma and MC1

131 This ligand will serve as a useful in vivo molecular probe for the investigation of the roles of th

132 A molecular probe for the luminescent detection of adenosi

133 antibody and have the potential to serve as molecular probes for a variety of biomedical application

134 a step toward the next generation of optical molecular probes for advancing the understanding of lipi

135 Conversely, there are a plethora of molecular probes for alternative in vivo vascular imagin

136 using EETI 2.5F and EETI 2.5-Fc as targeted molecular probes for brain tumor imaging.

137 holds a great promise in developing specific molecular probes for cancer diagnosis and cancer biomark

138 ncer-specific aptamers hold great promise as molecular probes for cancer early diagnosis and basic me

139 fective anti-Toxoplasma trioxanes as well as molecular probes for elucidating the mechanism of action

140 tagonists of LRH-1 could be used as specific molecular probes for elucidating the roles of the recept

141 operties enable diverse applications of SWIR molecular probes for fluorescence microscopy using conju

142 n of 19 of the genes and identified a set of molecular probes for genes that are up-regulated in the

143 Furthermore, the existing luminescent molecular probes for H(2)S cannot monitor it continuousl

144 cess to this growing chemical toolbox of new molecular probes for H2S and related RSS sets the stage

145 ecessary confirmation for the development of molecular probes for Hg-methylation in nature.

146 The key requirements of suitable molecular probes for in situ monitoring of ROS are prese

147 easingly important in the development of new molecular probes for in vivo imaging, both experimentall

148 dings have implications on the design of LNA molecular probes for intracellular monitoring applicatio

149 These inhibitors represent novel molecular probes for modulating gene regulation mediated

150 endocytic ligands, represent a new class of molecular probes for quantitative imaging of endocytic r

151 d molecules were then evaluated as potential molecular probes for small-animal HER2 PET by use of a S

152 his paper, we describe a new way to generate molecular probes for specific recognition of cancer cell

153 ial enrichment) method for the generation of molecular probes for specific recognition of liver cance

154 nyl)propyl-N,N-bis(4-fluorophenyl)amines, as molecular probes for the dopamine transporter (DAT).

155 The lack of molecular probes for the isolation of this protein has m

156 AMACR the ideal candidate for development of molecular probes for the noninvasive identification of p

157 en developed in order to provide a series of molecular probes for the quantification of intracellular

158 will assist in the development of selective molecular probes for the study of this and structurally

159 uation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of alpha V bet

160 As molecular probes for this study, derivatives of isopropy

161 This research provides valuable, new molecular probes for use in exploring HDAC biology.

162 sections on absorptiometric and luminescent molecular probes for use pH in sensors.

163 and INCh2 therefore represent important new molecular probes for Viridiplantae research.

164 and offers the potential to rapidly assemble molecular probes from an array of structurally diverse,

165 The generation of molecular probes from other families of CBMs will dramat

166 tachment of antibodies to yield gold nanorod molecular probes (GNrMPs).

167 n attached to the GNRs to yield gold nanorod molecular probes (GNrMPs).

168 The lack of molecular probes hampers the research in this area.

169 accessible new class of near infrared (NIR) molecular probes has been synthesized and evaluated.

170 Novel molecular probes have been developed for the analysis an

171 A variety of methods and molecular probes have been developed, but long term (fro

172 Hyperpolarized (13)C labeled molecular probes have been used to investigate metabolic

173 Lesion-specific molecular probes have been used to study polymerase-medi

174 Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing exce

175 vide a flexible system that utilizes CBMs as molecular probes in a range of applications.

176 d compounds for drug discovery and excellent molecular probes in biomedical research.

177 l building blocks for chemical synthesis, as molecular probes in chemical genomics and systems biolog

178 earch in molecular imaging shows promise for molecular probes in endoscopy, using fluorescently label

179 s an important target for the development of molecular probes in oncology because of its 10-fold high

180 Phenylenediamine derivatives are utilized as molecular probes in the solid state on a nanoporous memb

181 enable to click chemistry and can be used as molecular probes in vitro and in vivo.

182 Studies with small molecular probes indicate that these self-assembled arch

183 Self-assembly of molecular probes into supramolecular nanoprobes presents

184 systems to deliver BBB-impermeable targeted molecular probes into the brain for diagnostic neuroimag

185 ed using the sensitive DNA dye SYBR Green I (Molecular Probes-Invitrogen).

186 demonstrates that operating a robust single-molecular probe is not restricted to ultra-high vacuum a

187 Competitive adsorption among the three molecular probes is clearly resolved by in situ SFG meas

188 chiral compounds by chiroptical sensing with molecular probes is increasingly attractive for high-thr

189 ome- or dendrimer-based cellular delivery of molecular probes is inefficient, slow, and often detrime

190 ization of protein molecules conjugated with molecular probes is performed by UV-vis spectroscopy.

191 et the poor cellular uptake of water-soluble molecular probes limits their use as protease sensors.

192 In conclusion, we have used a novel molecular probe (mAb C9BB) to demonstrate the existence

193 By combining the information of different molecular probes, multi-target molecular MRI holds the p

194 tide substrate represents a highly sensitive molecular probe of palmitoyl acyltransferase activity th

195 tretch of potassium thiocyanate is used as a molecular probe of the heterogeneity of the interfacial

196 This work shows how catechol, a molecular probe of the oxygenated aromatic hydrocarbons

197 their discriminative potential and value as molecular probes of the corresponding transcriptome.

198 ric dissolved organic matter (CDOM) by using molecular probes of varying hydrophobicity.

199 across a range of ages and fitness levels by molecular probing of multiple tissues before and after a

200 The combination of MR imaging and molecular probes offers exciting possibilities of direct

201 In conjunction with specific molecular probes, optical coherent tomography (OCT) is a

202 ping a rationale for designing purpose-built molecular probes or chemodosimeters as well as newer rea

203 pounds are essential to their application as molecular probes or therapeutic agents.

204 elf-assembled monolayer for conjugation of a molecular probe reporter (ovalbumin or mouse IgG) to doc

205 ated in radiofluorogenic droplets containing molecular probes sensitive to byproducts of ionizing rad

206 Monitoring multiple molecular probes simultaneously establishes their correl

207 t circumvents many of the limitations of the molecular probe Singlet Oxygen Sensor Green((R)) (SOSG).

208 ibitors on the basis of the highly selective molecular probe Skepinone-L is described.

209 ally, rather than experimentally, by placing molecular probes (small molecules or functional groups)

210 Solvent mapping moves molecular probes, small organic molecules containing var

211 Computational mapping places molecular probes--small molecules or functional groups--

212 The method moves molecular probes--small organic molecules containing var

213 n of ionization enabled their application as molecular probes (standards) for determining the acidity

214 Fluorescent molecular probe studies indicate that the O2 (-) species

215 Although many molecular probes such as aptamers and antibodies can rec

216 the decomposition rate of suitably selected molecular probes, such as 4-hydroxybenzoic acid and meth

217 ds has been greatly supported by fluorescent molecular probes, such as thioflavin-T, which shows an i

218 acent to the active site by docking of small molecular probes suggest that it plays a crucial role by

219 -infrared pH-sensitive fluorescence lifetime molecular probe suitable for biological applications in

220 In combination with a molecular probe targeting angiogenesis, this approach ma

221 combination of optical windows with specific molecular probes targeting the tumour microenvironment w

222 A wide range of molecular probing technologies involving real-time polym

223 Here we report a new type of fluorescent molecular probe, termed a chameleon NanoCluster Beacon (

224 diabetes development, there is currently no molecular probe that allows measurement of hepatic gluco

225 eat importance, as there is barely any other molecular probe that can provide similar information.

226 We now present a small-molecular probe that smoothly reacts with amino acids an

227 The infrared RGD molecular probe that tracks integrin expression can be s

228 The development of molecular probes that allow in vivo imaging of neural si

229 wide variety of commonly used nanoscale and molecular probes that are otherwise limited.

230 f this field relies on the identification of molecular probes that can effectively interrogate pathwa

231 iomedical sciences is to devise a palette of molecular probes that can enable simultaneous and quanti

232 Thus, molecular probes that can selectively target quadruplex-

233 ray scattering signatures from high-contrast molecular probes that correlate with the presence of bio

234 dy is to identify liver cancer cell-specific molecular probes that could be used for liver cancer rec

235 osis; however, its success is dependent upon molecular probes that demonstrate selective tissue targe

236 Furthermore, the use of selective molecular probes that enable histochemical differentiati

237 ation of the MAP-based scaffold by designing molecular probes that fluoresce only after enzymatic tre

238 conditions and diseases requires the use of molecular probes that form stable, easily detectable, pr

239 Biosensors are molecular probes that have been developed to directly tr

240 Here we discuss some of the molecular probes that illustrate this shift from a "one

241 be low throughput or require preselection of molecular probes that limit the information obtained.

242 poly(A) and poly(dA) x poly(dT) can serve as molecular probes that report the pH and free salt concen

243 We highlight efforts towards both molecular probes that respond to disease-specific cataly

244 Based on the combined information from both molecular probes, the rupture of AAAs could reliably be

245 conjugation of proteins to amine-containing molecular probes through formation of a thiourea bridge.

246 this RABV entry inhibitor establishes a new molecular probe to advance further mechanistic and struc

247 In summary, this ligand provides a novel molecular probe to assess the specific role of P2X4 in i

248 as a potent MmpL3 inhibitor, and use it as a molecular probe to demonstrate the requirement for funct

249 -type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential o

250 toinduced charge transfer between a QD and a molecular probe to even low-affinity binding events at t

251 5-fluoropentanoic acid (AFPA), was used as a molecular probe to examine the reactivity of PLP in both

252 intravenous injection of an oxygen-sensitive molecular probe to generate phosphorescence optical sect

253 al component of catecholamine agonists) as a molecular probe to identify mechanistic differences betw

254 specific synthetic antibody and used it as a molecular probe to map functional domains within nicastr

255 This new approach allows a new type of the molecular probes to be well manipulated to monitor impor

256 terface are new targets for the discovery of molecular probes to block association of LSD1/CoREST wit

257 changes at an interface functionalized with molecular probes to detect label-free biomolecular bindi

258 Next, using specific molecular probes to discriminate the rare black morph of

259 be a promising starting point for exploring molecular probes to elucidate biological functions and t

260 e nonspecific proteins (i.e., BSA) as innate molecular probes to explore FG domain conformational cha

261 Our results highlight a set of novel molecular probes to further elucidate druggable mechanis

262 ific advances in both functional imaging and molecular probes to improve our understanding of the mol

263 hen discuss applications of state-of-the-art molecular probes to interrogate important aspects of car

264 resent an important advance toward using NIR molecular probes to measure the polarity of complex biol

265 Surprisingly, molecular probes to monitor GalNAc-transferase activity

266 ork extends the application of conotoxins as molecular probes to non-excitatory cells, such as macrop

267 are designed as a novel class of luminescent molecular probes to produce extraordinary chemiluminesce

268 hod that samples atomic hotspots with simple molecular probes to produce fragment hotspot maps.

269 Currently, there are no effective molecular probes to recognize biomarkers that are specif

270 es for the treatment of HCV infection and as molecular probes to study HCV pathogenesis.

271 These findings are useful in developing molecular probes to study negative energy balance condit

272 vide potential therapeutic lead compounds or molecular probes to study p300/HIF-1alpha interactions a

273 disorders, and as such, there is a need for molecular probes to study this receptor.

274 actions by distributing different aspects of molecular probe trajectories into distinct locations and

275 struct that is able to accommodate the small molecular probes used for the mapping, but has a too nar

276 To answer this question, six molecular probes using available DNP isomers were develo

277 A molecular probe was developed to monitor caspase activit

278 A molecular probe was prepared that selectively responds t

279 Exploiting dATP as a molecular probe, we assess how small changes in myosin s

280 Using a novel molecular probe, we characterized the activity pattern o

281 a metal ion chelator beta-thujaplicinol as a molecular probe, we observed a second mode of metal ion

282 microtubule-associated protein, Astrin, as a molecular probe, we show that end-on attachments are rap

283 NMR spectroscopy of tethered carbamates as a molecular probe, we systematically investigate the degre

284 By incorporation of C(2)TCO into fluorescent molecular probes, we demonstrate highly efficient extrac

285 ohydrate microarrays with the specificity of molecular probes, we have developed a sensitive, high th

286 Using human autoimmune sera as molecular probes, we previously described the associatio

287 nitrite, nitric oxide, and hydroxylamine as molecular probes, we show that the active site for the o

288 this DDS, three fluorescent and fluorogenic molecular probes were designed, synthesized, characteriz

289 AP domain flexibility, 2-aminopurine labeled molecular probes were employed in steady state fluoresce

290 Molecular probes were not necessary.

291 which increase in the presence of a Gd-based molecular probe, were significantly higher within the li

292 me the single-molecule spectroscopy of a new molecular probe which uses an intramolecular electron tr

293 Here we introduce a molecular probe, which upon proteolytic processing is re

294 developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, a

295 he interaction and speciation of Eu(3+) as a molecular probe with the mineral as a function of time.

296 There exists by now many molecular probes with absorption and fluorescence proper

297 lently connected, self-threaded, fluorescent molecular probes with figure-eight topology, an encapsul

298 ification, light-emitting new materials, and molecular probes with long-lasting light emission and im

299 We demonstrate that a molecular probe, with a pro-fluorophore substrate and li

300 CA represents a novel class of Dnmt-targeted molecular probes, with biochemical properties that allow