ライフサイエンスコーパス: molecular switch

1 A acts as a phosphorylation-dependent ON/OFF molecular switch.

2 n of keratinocyte migration via a dual-state molecular switch.

3 nd is thought to involve the activation of a molecular switch.

4 apping through a simple interaction model: a molecular switch.

5 The most appealing example is the molecular switch.

6 ecule 1 to function as a mechanically driven molecular switch.

7 ction of a working prototype of a biomimetic molecular switch.

8 ligand- and counterion-gated conformational molecular switch.

9 tals containing a very small quantity of the molecular switch.

10 ls, enabled by a visible-light-driven chiral molecular switch.

11 elongation factor (EF) Tu as a prototypical molecular switch.

12 ns, supra-linear responses, and long-lasting molecular switches.

13 zation of dithienylethenes, a major class of molecular switches.

14 acceptor oligorotaxane foldamers, a class of molecular switches.

15 n principle for enhancing the performance of molecular switches.

16 erions, a practical limitation in the use of molecular switches.

17 azine-1,6-dicarboxamides as redox-responsive molecular switches.

18 multiple post-translational modifications as molecular switches.

19 be used in biosensors or assays that exploit molecular switching.

20 hat the inhibition of FGFR4 signaling caused molecular switching.

21 We propose that this molecular switch acts to drive progressive cell commitme

22 Biased modulation, probe dependence, and molecular switches all contribute to the complex molecul

23 This molecular switch also regulates the closely related fami

24 Ras GTPases act as "molecular switches", alternating between inactive GDP-bo

25 he role of electron transfer in triggering a molecular switch and in altering water-mediated interfac

26 ptor phytochrome A acts as a light-dependent molecular switch and regulates responses initiated by ve

27 Here, the new light-driven chiral molecular switch and upconversion nanoparticles, doped i

28 oning of the amide group with respect to the molecular switch and works synergistically with Tyr-73 t

29 They act as molecular switches and are primarily regulated by the ex

30 a pathway for designing robust platforms for molecular switches and biosensors based on the aforement

31 h for the design and creation of solid-state molecular switches and machines.

32 ance further design of novel photoresponsive molecular switches and mechanically interlocked molecule

33 mic behavior of a series of novel tetrapodal molecular switches and motors containing common function

34 V/vis absorption spectroscopy shows that the molecular switches and motors retain their ability to un

35 for facilitating the extraction of work from molecular switches and motors.

36 in the design of single-atropisomer drugs or molecular switches and motors.

37 Ras-like small GTPases function as molecular switches and regulate diverse cellular events.

38 e used for sensing analytes other than pH or molecular switching and signaling.

39 application of single-molecule junctions as molecular switches, and general physical phenomena in si

40 de exchange factors, the activators of these molecular switches, and their upstream signaling partner

41 ificant extension of their lifetimes, facile molecular switching, and extremely large stabilization e

42 ices using cholesteric films containing this molecular switch are described.

43 erstanding the working of the protein kinase-molecular switch as an allosteric network of "communitie

44 dow carrying immobilized aptamer/quantum dot molecular switches as a part of a portable fluorescent s

45 stals fabricated using these new fluorescent molecular switches as chiral dopants exhibit reversible

46 In turn, the use of molecular switches as control units within host-guest as

47 complexes in aqueous media with appropriate molecular switches as guests.

48 ed progressive changes, we observed a sudden molecular switch at a critical precancer stage, by devel

49 The doublesex (dsx) gene functions as a molecular switch at the base of the insect sex determina

50 lled RhoGDI regulates the activity of these 'molecular switches' at the plasma membrane.

51 propose that pUL135 and pUL138 constitute a molecular switch balancing states of latency and reactiv

52 A six level molecular switch based on terpyridine(Ni-salphen)2 tweez

53 proach for the construction of protein-based molecular switches based on artficially autoinhibited pr

54 Aptamers are useful as molecular switches because they offer excellent binding

55 ar interest as electrochemically addressable molecular switches because, in contrast with more conven

56 bers of which are Cdc42, Rac1, and RhoA, are molecular switches best known for regulating the actin c

57 nd remove a single modification can act as a molecular switch between "on" and "off" and has been wid

58 eover, it suggests that this lipid acts as a molecular switch between fission and fusion.

59 nt for the transition from life to death.The molecular switch between how tumour necrosis factor (TNF

60 s study uncovers CD271 as a context-specific molecular switch between normal development and malignan

61 ription processivity and thereby serves as a molecular switch between replication and transcription,

62 The molecular switch between RIPK1 pro-survival and pro-deat

63 al stimulus have been used to activate these molecular switches between bistable or even multiple sta

64 We propose that MARCKS acts as a "molecular switch," binding to and regulating PIP2 signal

65 that hGBP1F acts as a nucleotide-controlled molecular switch by modulating the accessibility of its

66 IM software can be exploited to identify key molecular switches - called "switch genes" - for the dis

67 to-trans isomerization process of the chiral molecular switch can be caused by blue light (440 nm).

68 They function as molecular switches capable of altering gene expression;

69 We propose that sFRPs can act as a molecular switch, channeling the signal input for differ

70 ceptors (FZD(4,5,6,7,) SMO), mutation of the molecular switch confers an increased potency of agonist

71 ummary, the 2'OH group seems to be a primary molecular switch contributing to specific protein-RNA re

72 e of Science Signaling, Rizk et al. define a molecular switch controlled by the cellular inhibitor of

73 Ras GTPase is a molecular switch controlling a number of cellular pathwa

74 covered microRNA-21 (miR-21) as a downstream molecular switch controlling macrophage activation and i

75 t two neighboring G-quadruplexes behave as a molecular switch controlling the expression of HRAS.

76 nsic curvature of the FtsZ filaments and the molecular switch coupled to the high-affinity end-wise a

77 the plasma membrane where it functions as a molecular switch, coupling extracellular growth factor s

78 To develop molecular switches de novo, an intimate understanding of

79 chemistry; sensors; host-guest complexes for molecular switching devices, such as catenanes and rotax

80 f a highly-absorbing negatively photochromic molecular switch, donor acceptor Stenhouse adduct (DASA)

81 By altering PKA activity PKI can act as a molecular switch, driving GPCR-Galphas-cAMP signaling to

82 available achiral liquid crystal hosts, this molecular switch efficiently induces luminescent helical

83 These versatile materials consist of molecular switches embedded in liquid-crystalline polyme

84 Finally, molecular switches embedded in self-assembled monolayers

85 Visible-light-driven molecular switches endowing reversible modulation of the

86 It was found that this relatively rigid molecular switch exhibited a high helical twisting power

87 addressable, multistate, and multifunctional molecular switches exhibiting contrasts of both linear a

88 The cyclic-azobenzene-based chiral molecular switch exhibits reversible photoisomerization

89 The chiral molecular switch exhibits trans-to- cis photoisomerizati

90 11-cis-retinal that functions not only as a molecular switch for activating cone and rod visual pigm

91 modification of histone H3K27 acts as a key molecular switch for activation or suppression of many c

92 single divergent amino acid, highlighting a molecular switch for chloride insensitivity that is tran

93 e propose that Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-d

94 Alternatively, a molecular switch for fusion offers a route to mixing dro

95 monstrate that DNA can behave as a promising molecular switch for molecular electronics applications

96 cription factors and show that AHR acts as a molecular switch for monocyte fate specification in resp

97 ion gene Olig2 expression and functions as a molecular switch for oligodendrocyte and astrocyte linea

98 r, these results indicate that TOR acts as a molecular switch for the activation of cell proliferatio

99 We propose that the molecular switch for the loss of transverse tubules in H

100 lysis, we show that bilirubin functions as a molecular switch for the nuclear receptor transcription

101 show that cellular ATP level might act as a molecular switch for Thr55 phosphorylation on the p21 pr

102 , we identify a single residue (A/P205) as a molecular switch for TraA recognition.

103 Overall, we propose that HPSE acts as a molecular switch for turning a virus-permissive 'attachm

104 LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on RP mRNA translati

105 s endogenous opsin-mediated, light-activated molecular switch for vasorelaxation might be harnessed f

106 ate immune responses by acting as one of the molecular switches for immunity or suppression.

107 otide exchange factors (GEFs), are conserved molecular switches for signal transductions that regulat

108 lts indicate that distinct MMPs might act as molecular switches for specific types of LTP.

109 obilize nearby amino acid residues to act as molecular switches for the formation of a continuous wat

110 he band 3-deoxyHb interaction constitutes a "molecular switch" for regulating erythrocyte biology, we

111 t PKR activation is an essential part of the molecular switch from adaptation to inflammation in resp

112 Furthermore, we describe the molecular switch from cytokine receptor to pre-BCR signa

113 hypothesis whereby IL-13Ralpha2 serves as a molecular switch from invasion to proliferation, and sug

114 y poised as therapeutic targets due to their molecular switch function in turning gene expression on

115 Combining different molecular switching functions in a single molecule is a

116 Molecular switches gate many fundamental processes in na

117 ese opposing signaling cascades serve as the molecular switch gauging Ag dose.

118 transcriptional network, where it acts as a molecular switch governing the balance between TSC proli

119 n, two novel light-driven chiral fluorescent molecular switches have been designed and synthesized th

120 s of well-known organic receptors allows the molecular switches implemented within their structures t

121 ll GTPase RAS to hydrolyze GTP, keeping this molecular switch in a constitutively active GTP-bound fo

122 system is presented that does not rely on a molecular switch in different toggling states but on a s

123 Here, we reveal a defective molecular switch in head and neck squamous cell carcinom

124 The ability of this pathway to function as a molecular switch in lens differentiation depends on the

125 mperature coaction in the circuitry drives a molecular switch in PIF activity and control of cell exp

126 curs in the cell in which KRAS operates as a molecular switch in signaling pathways.

127 ts suggest that the MED26-NTD functions as a molecular switch in the exchange of TBP-associated facto

128 ctive and inhibited receptor states reveal a molecular switch in the modulatory binding site that med

129 Mechanistically, TAK1 functions as a molecular switch in tumor necrosis factor receptor-1 sig

130 ledge, this is the first example of a chiral molecular switch in which the visible-light-driven azobe

131 re, investigating mechanisms that constitute molecular switches in a central metabolic organ like the

132 Galpha subunits are central molecular switches in cells.

133 s have great potential to be incorporated as molecular switches in highly demanding and multivalent p

134 The incorporation of molecular switches in organic structures is of great int

135 essing the mechanically purposeful motion of molecular switches in supramolecular tubules.

136 Rab proteins, which are considered to act as molecular switches in vesicular trafficking using HepG2.

137 oth with resolution <7 nm), it is shown that molecular switching in the films is uniform from hundred

138 Spiropyran molecular switches, in conjunction with transition metal

139 , which is subject to regulation by multiple molecular switches, including mTOR and hypoxia-inducible

140 at the helical twisting power of this chiral molecular switch increases upon irradiation with green l

141 The small GTPases H, K, and NRAS are molecular switches indispensable for proper regulation o

142 These chiral molecular switches induce photoresponsive helical supers

143 re we identify nuclear factor IA (NFIA) as a molecular switch inducing human glial competency.

144 hat this phosphorylation site may serve as a molecular switch, influencing the affinity of the PDZ bi

145 as they are often crucial for embedding the molecular switch into a system of interest.

146 a judiciously chosen thermoresponsive chiral molecular switch into an achiral liquid crystalline medi

147 Previous attempts to incorporate molecular switches into thermally stable photoisomers we

148 ily of small GTPases that function as binary molecular switches involved in cell signaling.

149 We found that the molecular switch involves a hydrogen bond interaction be

150 Here we describe a molecular switch involving a highly conserved anion bind

151 Activation of Y2R is mediated by molecular switches involving the toggle switch residue T

152 A molecular switch is defined as a molecule that displays

153 Here a new visible-light-driven chiral molecular switch is synthesized and characterized.

154 erstanding of the translational movements in molecular switches is essential for designing machine-li

155 Substantial chiral-achiral molecular switching is observed in di(haloacetyl) bispid

156 s inversion, enabled by a halogen bond donor molecular switch, is unprecedented.

157 This molecular switching manifold exploits intramolecular cou

158 used to construct an oxidation-state-coupled molecular switching manifold that reports its switch-sta

159 We report a molecular switch mechanism controlling polarity orientat

160 lex and i-motif, providing a rationale for a molecular switch mechanism driven by SP1-induced negativ

161 However, the molecular switch mechanism from autoinhibited to the act

162 l and functional studies elucidate a dynamic molecular switch mechanism that governs the repression a

163 This molecular switching mechanism can couple AP2's membrane

164 This, in fact, is a puzzle because a molecular switching mechanism should ideally be isotropi

165 esults implicate vinculin translocation in a molecular switching mechanism that senses substrate visc

166 imotor gliding assays and sheds light on the molecular switching mechanism.

167 hree supramolecular chemistry related areas: molecular switches, metallo-assemblies and sensors.

168 Rab GTPases are molecular switches mobilizing intracellular vesicles, an

169 r (RXR) is revealed, and an extension of the molecular switch model of the nuclear receptor action is

170 tion of T406 can be regarded as an important molecular switch modulating TRPV1-related behavior and p

171 We have identified a new molecular switch, namely mAKAPbeta signalosome-regulated

172 active molecular units such as photochromic molecular switches, nanomachines based on mechanical bon

173 We propose that a unique molecular switch occurs during lamprey metamorphosis res

174 ding membrane-proximal domain, which acts as molecular switch of ADAM17 activity operated by a protei

175 phogenic9 (COP9) signalosome (CSN) acts as a molecular switch of CRLs activity by reverting their ned

176 tudies of microRNAs (miRNAs), which act as a molecular switch of gene expression, have shown promise

177 Troponin I (TnI) is the molecular switch of the sarcomere.

178 s these effects through a novel mechanism of molecular switching of LPS signaling from predominant ac

179 he use of low-intensity NIR light to operate molecular switches offers several potential advantages i

180 Su(H) operates as molecular switch on Notch target genes: within activator

181 Over the past decade, molecular switches on surfaces have been intensely inves

182 gs") was coupled to maleimide-functionalized molecular switches or motors under ambient conditions.

183 crystals enabled by photoisomerizable chiral molecular switches or motors.

184 different stimuli have potential for use in molecular switching or sensing applications.

185 g complexes and their localization, serve as molecular switches, or regulate signaling networks throu

186 s enabled by light-driven chiral fluorescent molecular switches pave a new way for developing novel d

187 Protein-based molecular switches play critical roles in biological pro

188 s as functional materials that can undergo a molecular "switching" process, performing complex functi

189 tional output of EF and GC responses and the molecular switches promoting them.

190 timately disease development, depends on the molecular switch protein, ZEBRA, a viral bZIP transcript

191 Hence insulin signaling to the molecular switch Rab8A connects with the motor protein M

192 ctivated RhoA/ROCK signalling functions as a molecular switch regarding the fate of MSCs in arterial

193 Rab-GTPases are important molecular switches regulating intracellular vesicle traf

194 ious work on the o-hydroxychalcone/flavanone molecular switching scaffold showed that simple substitu

195 nd 7 (mGlu1-5,7) highlighting key concepts ("molecular switches", signal bias, heterodimers) and prac

196 These findings reveal a critical molecular switch, specifying Treg function through the m

197 potential in various applications including molecular switch, spin memory device, molecular battery,

198 Molecular switches such as GTPases are powerful devices

199 r to achieve this, a new class of rod-shaped molecular switches, suitable for formation of 2-D regula

200 uggest a new approach for the development of molecular switching systems and storage-class memories.

201 of CORVET/HOPS, we find that VPS11 acts as a molecular switch that binds either CORVET-specific TGFBR

202 t time we propose that the i-motif acts as a molecular switch that controls gene expression and that

203 Thus, PAI-1 is a molecular switch that controls the cardiac TGF-beta axis

204 Thus, As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an act

205 ether, our findings identify DNA-PKcs as the molecular switch that coordinates end-processing and end

206 iR-218 in the adult mPFC might function as a molecular switch that determines susceptibility vs. resi

207 y the metalloproteinase inhibitor TIMP1 as a molecular switch that determines the effects of senescen

208 The aim of this study was to identify the molecular switch that determines whether the AhR acts as

209 R of Med13 plays a key role in controlling a molecular switch that dictates cell fate following expos

210 rated by isomerization of a light-responsive molecular switch that drives the twisting of strips of l

211 gether with calmodulin 2 (CaM2) constitute a molecular switch that either opens or closes the calcium

212 ased visible-light-driven chiral fluorescent molecular switch that exhibits reversible trans to cis p

213 that PINK1-Parkin constitutes a damage-gated molecular switch that governs cellular-context-specific

214 ylation of the RRM2 subunit of RNR acts as a molecular switch that impacts RNR activity, dNTP synthes

215 Our data implicate AC DNA methylation as the molecular switch that imprints their regulatory properti

216 An auto-inhibitory segment of Apc1 acts as a molecular switch that in apo unphosphorylated APC/C inte

217 of JAM-A may thus act as a barrier-inducing molecular switch that is activated when cells become con

218 TAT1 transcriptional activity) as a critical molecular switch that is secreted by intracellular paras

219 echanism of melanoma formation: miR-211 is a molecular switch that is turned off in melanoma cells, r

220 Thus, in this case, IL-13 acts as a molecular switch that leads to resolution of inflammatio

221 activities of Aurora B and CENP-I generate a molecular switch that maintains a robust spindle checkpo

222 can epigenetically silence BIM expression, a molecular switch that prevents apoptosis.

223 et of learning and memory is the notion of a molecular switch that promotes the formation of long-ter

224 relate with pH and ionic strength controlled molecular switch that regulated HUalphaalpha dependent i

225 B, within CeA Crh neurons, may function as a molecular switch that regulates expression of fear and i

226 findings suggest a new role for MCPIP1 as a molecular switch that regulates fibroblast migration in

227 e phosphorylation of PTPROt at Tyr(399) is a molecular switch that selects between its opposing activ

228 The troponin complex is a molecular switch that ties shifting intracellular calciu

229 this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in res

230 nd provide evidence that the coreceptor is a molecular switch that undergoes ligand-induced conformat

231 he Glu(3) --> Ala substitution resulted in a molecular switch that was transmitted to adjacent residu

232 Protein kinases are molecular switches that are optimized for their regulati

233 nd StkP protein kinase have been proposed as molecular switches that balance septal and peripheral (s

234 Molecular switches that change their conformation upon t

235 extend and improve these methods to predict molecular switches that characterize conformational chan

236 We have created molecular switches that consist of nucleic-acid cleaving

237 Heterotrimeric G proteins are key molecular switches that control cell behavior.

238 RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell grow

239 A better understanding of the molecular switches that control the apoptosis sensitivit

240 We identify two molecular switches that coordinate nuclease and kinase f

241 These proteins function as molecular switches that cycle between active and inactiv

242 ses are characterized as membrane-associated molecular switches that cycle between active, GTP-bound

243 of two novel halogen bond donor based chiral molecular switches that exhibit reversible photoisomeriz

244 Heterotrimeric G proteins are important molecular switches that facilitate transmission of a var

245 The cell cycle is composed of bistable molecular switches that govern the transitions between g

246 y an array of equilibrium and nonequilibrium molecular switches that harmonize to promote functional

247 ure coupling energies between side chains in molecular switches that mediate shear during domain moti

248 Rho GTPases are molecular switches that modulate a variety of cellular p

249 ms that will serve to further understand the molecular switches that occur during cartilage to bone t

250 Small GTPases of the Rho family are binary molecular switches that regulate a variety of processes

251 T cells in tumor-bearing mice by introducing molecular switches that regulate cell fate decisions via

252 mbers of the Rab family of small GTPases are molecular switches that regulate distinct steps in diffe

253 Heterotrimeric G proteins are molecular switches that relay intracellular signaling in

254 Rho GTPases are molecular "switches" that cycle between "on" (GTP-bound)

255 d form a Schiff base with MR1, triggering a 'molecular switch' that allows MR1-VitB antigen complexes

256 ection of tetracycline based on triple-helix molecular switch (THMS) and gold nanoparticles (AuNPs).

257 dependent change, this region could act as a molecular switch to activate HIV-1 Gag for VLP assembly.

258 show that Ser-322 phosphorylation acts as a molecular switch to control the subcellular distribution

259 omeostasis, YAP/TAZ function as the critical molecular switch to coordinate growth and patterning in

260 direct target of the insulin receptor, as a molecular switch to coordinate this process.

261 PINK1-Parkin operates as a molecular switch to dictate cell fate decisions in respo

262 is suggested in which this is employed as a molecular switch to fine tune the relative expression of

263 ol of autophagosome formation, and provide a molecular switch to fine-tune the activation of autophag

264 ation of the activation loop in MLKL trips a molecular switch to induce necroptotic cell death.

265 anslational modification that functions as a molecular switch to link changes in redox balance with e

266 d in TM6 in Class F receptors that acts as a molecular switch to mediate receptor activation.

267 actor-like 4C (Arl4C) small GTPase acts as a molecular switch to regulate morphological changes and c

268 e region, and that this event functions as a molecular switch to regulate subsequent glycosaminoglyca

269 Thus, MglA acts as a nucleotide-dependent molecular switch to regulate the motility machinery spat

270 poles, suggesting phosphorylation acts as a molecular switch to specifically activate cortical Mud f

271 Ras GTPases act as molecular switches to control various cellular processes

272 of kinases and phosphatases that act as key molecular switches to fine tune cellular events.

273 ectronics applications from designing robust molecular switches to nanoelectronic DNA sequencing.

274 Rab GTPases serve as molecular switches to regulate eukaryotic membrane traff

275 s mechanism allows the photoisomerization of molecular switches to stimulate rapid shape changes at t

276 The aptamer complexes were designed as molecular switches to undergo conformational change and

277 herapy, the use of light as a photochemical "molecular switch" to promote differentiation should expa

278 Rational molecular designs of chiral molecular switches toward endowing handedness inversion

279 We begin by presenting the molecular switches triggered by various external stimuli

280 is review is to highlight recent advances in molecular switches triggered by various external stimuli

281 nt on HD1, we propose that GDAP1 undergoes a molecular switch, turning from a pro-fission active to a

282 This unique molecular switch undergoes structural isomerisation in r

283 nd designed soluble proteins into allosteric molecular switches useful in biodesign, sensing, and syn

284 of the full cycle of motion in this class of molecular switch using cyclic voltammetry.

285 We propose a model by which, via this molecular switch, W-acidic cargo binding regulates the a

286 ata indicate that UL135 and UL138 comprise a molecular switch whereby UL135 is required to overcome U

287 Ser-379 phosphorylation is a molecular switch which initiates p47(phox) conformationa

288 Similarly, molecular switches which respond to reactivation are imp

289 erformances allow the execution of an 8-step molecular switch, which renders this molecular system th

290 proceed through the programmed operation of molecular switches, which trigger both local and global

291 ins, comprising Ga, Gb, and Gg subunits, are molecular switches whose function tightly depends on Ga

292 Understanding such molecular switches will be critical for vaccine developm

293 tal (CLC) containing a photosensitive chiral molecular switch with high helical twisting power.

294 for converting virtually any aptamer into a molecular switch with pH-selective binding properties -

295 Interestingly, the molecular switch with terminal bromo atoms confers rever

296 nduced helical superstructure containing the molecular switch with terminal iodo atoms exhibits visib

297 g one of the light-driven chiral fluorescent molecular switches with ease of fabrication and operatio

298 perties of the AAPs could be tuned to obtain molecular switches with favorable photostationary states

299 Previous work has shown multi-state molecular switches with up to four and six distinct stat

300 We identified a molecular switch within murine (m)CD1d that modulates NK