ライフサイエンスコーパス: molecular target

1 and ERK5 as a novel, immediately actionable molecular target.

2 osomal protein L12 (RPL12/uL11) emerged as a molecular target.

3 nic middle ear inflammation, and a potential molecular target.

4 althy tissues that express low levels of the molecular target.

5 on of affinity reagents ("aptamers") against molecular targets.

6 benzodiazepine structure, they have distinct molecular targets.

7 8%) yielded concordant results for the three molecular targets.

8 roid hormone (TH) signaling through multiple molecular targets.

9 overy of bioactive small molecules and their molecular targets.

10 is unique alkaloid across panels of discrete molecular targets.

11 ove drug potency towards inhibition of their molecular targets.

12 ion in various forms of RP, and identify new molecular targets.

13 nd compare the findings across the different molecular targets.

14 the energy balance in mice through multiple molecular targets.

15 pectroscopy allows the detection of multiple molecular targets.

16 tremendous range of previously inaccessible molecular targets.

17 neralizable toward subsecond measurements of molecular targets.

18 iation studies (GWASs) to identify potential molecular targets.

19 tigational therapies for moderately frequent molecular targets.

20 , despite genomic sequencing, lack effective molecular targets.

21 ely used in bioanalytical methods to capture molecular targets.

22 ed cell signalling provide broadly conserved molecular targets.

23 ogical agents, dietary approaches, and novel molecular targets.

24 polar patients to further identify important molecular targets.

25 sm but are related to engagement of distinct molecular targets.

26 survival by regulating functions of various molecular targets.

27 properties, and the recognition of specific molecular targets.

28 ation allowing an efficient binding to their molecular targets.

29 ihood that approved excipients would bind to molecular targets.

30 ly selective covalent inhibitors for diverse molecular targets.

31 ging with high sensitivity and potential for molecular targeting.

32 However, the downstream molecular targets after BDNF release from ventral tegmen

33 es and leverages this knowledge to propose a molecular target against hyperlipidemia.

34 zed the management of advanced RCC; 10 novel molecular targeted agents and immune checkpoint inhibito

35 B) has merit, especially in combination with molecular targeted agents that inhibit heat shock protei

36 ostic information by specifically locating a molecular target altered in the disease process.

37 ctile gene program in disease, and reveals a molecular target amenable to therapeutic exploitation.

38 AOPEDF achieves high accuracy in identifying molecular targets among known drugs on two external vali

39 Systematic identification of molecular targets among known drugs plays an essential r

40 ties for network-based identification of new molecular targets among known drugs.

41 We have identified alpha(v)beta(6) as a molecular target; an epithelium-specific cell surface re

42 Together, our studies elucidate a specific molecular target and mechanism by which osthole induces

43 constrained by the lack of insight into the molecular target and mechanism by which these CRIDs inhi

44 Identification of molecular targets and anti-fibrotic therapies could prov

45 s on genomic profiling of the tumors to find molecular targets and develop specific agents for indivi

46 oside photo-inducible crosslinking on single molecular targets and developed a software package for r

47 r (AUD) emphasize the need to identify novel molecular targets and efficiently screen new compounds a

48 Here, we have elucidated the molecular targets and function of TRMT1 to uncover the c

49 The SSc disease module includes the emerging molecular targets and is in better accord with the curre

50 ure mechanistic studies to identify specific molecular targets and pathways that may be altered in ac

51 nhancer regions revealed putative oncogenes, molecular targets and pathways; inhibition of these targ

52 unds of the series potently inhibit all four molecular targets and show antimalarial activity compara

53 The identification of molecular targets and the growing knowledge of their cel

54 biology probes as a click handle to identify molecular targets and to assess target engagement.

55 f the patients with GBM is very poor and new molecular targets and treatment strategies are urgently

56 ions remain regarding their bioavailability, molecular targets, and mechanism of action.

57 Several of these new markers, molecular targets, and therapeutic approaches have been

58 sciousness, but the repertoire of underlying molecular targets, and thereby the genes, are incomplete

59 They bind their molecular target (antigen) by recognizing a portion of i

60 This molecular target approach signals an important step towa

61 Representing the enormous success of a molecular targeted approach, natalizumab was the first m

62 Using transgenic and circuit-specific molecular targeting approaches, we demonstrated that uni

63 Better risk prediction and new molecular targets are key priorities in type 2 diabetes

64 ants, their precise signaling properties and molecular targets are not well defined.

65 ies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncog

66 Consequently, a larger molecular target associated with a smaller receptor prov

67 us on identifying lead compounds acting on a molecular target associated with an established patholog

68 offer a solution to the stress ROS exert on molecular targets at the bacterial cell envelope.

69 herapeutic potential of different classes of molecular targets at various stages of development in CC

70 somes for the treatment of BC/TNBC and other molecular targets available such as poly (ADP-ribose) po

71 drug design and development due to potential molecular targets but also be an essential role in genom

72 nown of the distribution of their respective molecular targets, but crucially also revealed system-wi

73 ely limited by IR76b and uncover a potential molecular target by which contexts can modulate sensitiv

74 We identified cell signaling molecular targets by meta-analysis of microarray data se

75 Thus, identification of new molecular targets can significantly contribute to the de

76 Cell-based studies have identified several molecular target candidates of manassantin including NF-

77 ed to local availability of its main central molecular target, cannabinoid-1 (CB1) receptors in man.

78 T(reg) cells, there is a dearth of druggable molecular targets capable of increasing their numbers in

79 Dinaciclib suppressed expression of its molecular targets CDK2/5/9, and anti-apoptotic BCL-XL an

80 d, with a focused approach to understand the molecular targets, cellular effectors, and receptors.

81 This study aims to establish whether molecular targets change during tumor progression and, i

82 tigate the therapeutic potential of specific molecular targets, characterize various cellular functio

83 taneously or monovalently to their different molecular targets; coinjection of a cocktail of radiolig

84 nce 7) combined with LC-MS/MS identified its molecular target complex, whereof most proteins are part

85 iscuous binding to a wide range of different molecular targets, consistent with structural heterogene

86 h D2 autoreceptors and associated downstream molecular targets converging on GSK-3 and suggest a new

87 red molecular target, quantification of each molecular target could be exaggerated by nonspecific bin

88 Our results yielded novel candidate molecular targets driving the development of cardiovascu

89 h RF ablation is possible when combined with molecular-targeted drug delivery systems.

90 age, an inherent challenge in the use of any molecular-targeted drug in cancer settings.

91 learned that should pave the way for future molecular target evaluation in this uncommon yet bona fi

92 that controls iron mobilization through its molecular target ferroportin (FPN), the only known mamma

93 Moreover, HHK3 is a molecular target for antifungal agents such as fludioxon

94 The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several r

95 n colon cancer, and that GRM3 is a promising molecular target for colon cancer treatment.

96 ects, making GRM3 an attractive and specific molecular target for colon cancer treatment.

97 These properties render Hec1 a promising molecular target for developing therapeutic drugs that e

98 n serve as a diagnostic biomarker but also a molecular target for developing therapeutic regimens.

99 5-HT1BRs putatively represent a molecular target for development of pharmacologic antiag

100 Thus, SIRT2 may be a novel molecular target for diabetes therapy and may thus shed

101 This renders PIK3CA an attractive molecular target for early detection and personalised th

102 entified integrin alpha-2 (ITGA2) as a novel molecular target for GBM.

103 ese results establish miR-503 as a promising molecular target for glioblastoma therapy.

104 These findings identify TRPA1 as a molecular target for HQ and provide insights into the me

105 eceptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET.

106 on, and that SIRT6 should be considered as a molecular target for in vivo actions of these anti-infla

107 Thus, AhR might represent a novel molecular target for manipulation of B cell responses du

108 Downregulation of CD20, a molecular target for monoclonal antibodies (mAbs), is a

109 s of NASH and identify it as a potential new molecular target for NASH therapy.

110 ntly, we propose the Nav1.6 channel as a new molecular target for patients with KCNQ2 encephalopathy,

111 induced AKI, identifying PPIF as a potential molecular target for renoprotective intervention.

112 ed molecular mechanism of aPKC regulation, a molecular target for S1P in cell survival regulation, an

113 Moreover, they provide a molecular target for strategies aimed at attenuating ret

114 Here we identify a molecular target for the antischistosomal eutomer - (R)-

115 Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a molecular target for the sensitization of cancer cells t

116 -up study that identified MNT as a promising molecular target for the treatment and prevention of MYC

117 e that this precursor would provide a common molecular target for therapeutic intervention in the doz

118 to bone endothelial cells, and represents a molecular target for therapeutic intervention.

119 PP1 could constitute an efficient and direct molecular target for therapeutic interventions in Huntin

120 Thus, our data identify EphA2 as a novel molecular target for TNBC.

121 P(C) as a new and potentially more druggable molecular target for treating Alzheimer's disease.

122 FGFR1 in the kidney may provide a new molecular target for treating hypertension.

123 is study suggests that ALOX15 is a potential molecular target for treatment of ALD.

124 eases and has been identified as a potential molecular target for treatment of neurodegeneration.

125 PPARgamma is the molecular target for type 2 diabetes mellitus (T2DM) the

126 hosphodiesterases have emerged as attractive molecular targets for a novel treatment for a variety of

127 of potentially clinically useful genomic and molecular targets for a subset of recurrent/metastatic S

128 We selected 12 diverse molecular targets for Affimer selection to exemplify the

129 e emerged as diagnostic biomarkers and novel molecular targets for anti-cancer drug therapies.

130 l inhibitors of bacterial ureases, important molecular targets for antimicrobial therapies, was devel

131 t signaling toward aggregation and (2) novel molecular targets for antiplatelet treatment strategies.

132 virus replication have been sought as novel molecular targets for antiviral therapy.

133 Among the potential molecular targets for attaining these unmet therapeutic

134 These biomarkers could be valuable molecular targets for cancer drug discovery and developm

135 r cccDNA metabolism and function will reveal molecular targets for developing curative therapeutics o

136 , integrin alpha(4)beta(1)) are 2 attractive molecular targets for developing peptide radiopharmaceut

137 Together, our results identified molecular targets for developing pro-longevity microbes

138 N-alpha in hepadnaviral infection may reveal molecular targets for development of novel antiviral age

139 ce variants to serve as novel biomarkers and molecular targets for developmental therapeutics in aggr

140 The identification of new molecular targets for diagnostic and therapeutic applica

141 c analysis of dietary information may reveal molecular targets for disease prevention and treatment.

142 ation during atherosclerosis and to identify molecular targets for disease therapy, we combined SMC f

143 resent unique probing tools for discovery of molecular targets for diseases.

144 a survey of the studies that have suggested molecular targets for drug development for ASD and the s

145 tion studies offer opportunities to identify molecular targets for drug development.

146 t have emerged as attractive cancer-specific molecular targets for drug development.

147 eal potential biomarkers that may be used as molecular targets for future diagnosis of each combinati

148 hanisms of FTD and ALS and suggest promising molecular targets for future therapeutic interventions i

149 They also identify tissue-specific molecular targets for GM hemorrhage intervention.

150 gene networks, may represent biomarkers and molecular targets for intervention in PMD.

151 ential gene expression can be used to reveal molecular targets for intervention.

152 scular disease, and cancer, and they are the molecular targets for nonsteroidal anti-inflammatory dru

153 findings, if confirmed, suggest cellular and molecular targets for novel therapeutics that address ax

154 hat GLP-1 receptors could serve as potential molecular targets for pharmacotherapies aimed at reducin

155 ighly vulnerable human NP cells and identify molecular targets for potential therapeutic intervention

156 cinomas, highlighting their potential as new molecular targets for prevention or treatment of UVR-ind

157 chronic alcohol exposure and provides novel molecular targets for studying alcohol dependence.

158 Moreover, they suggest possible novel molecular targets for the abrogation of tumor microenvir

159 itors in tumor lymphangiogenesis and suggest molecular targets for their inhibition.

160 is an important factor in identification of molecular targets for therapeutic development based on m

161 mutant KRAS LUAD have proven to be potential molecular targets for therapeutic development.

162 ChRs and connexin hemichannels are potential molecular targets for therapeutic intervention in a vari

163 his knowledge may also yield next generation molecular targets for therapeutic intervention.

164 ould lead to the identification of potential molecular targets for therapeutics against Chlamydia.

165 lts provide a comprehensive priority list of molecular targets for translational research.

166 iption and receptor function may provide new molecular targets for treatment and prevention of hypert

167 Pathophysiology and molecular targets for treatment are largely unknown.

168 e report a method to screen and identify new molecular targets for tumor-targeted nanomedicine based

169 for high-risk myelodysplastic syndrome whose molecular target had remained controversial, pointed sin

170 novel therapies for cocaine addiction, but a molecular target has not yet been identified.

171 To determine whether LC3/GABARAP has other molecular targets, here we generated a pre-processed LC3

172 We developed the HVGGSSV peptide as a molecular targeting/imaging agent.

173 Nor1 represents a promising molecular target in diabetes treatment to prevent beta-c

174 not in reversal reaction and provides a new molecular target in ENL pathogenesis.

175 f the innate immune response and a potential molecular target in inflammatory disease.

176 ous HA matrix and may represent an important molecular target in physiology and disease.

177 ng the GABA shunt, GAD65 in particular, as a molecular target in the treatment of CRPC.See related ar

178 r immunohistochemistry to evaluate potential molecular targets in human tumor tissue sections.

179 on and disease, but noninvasive detection of molecular targets in living subjects often suffers from

180 ndings identify TREK1 and TREK2 as potential molecular targets in migraine and suggest that fsATI sho

181 sequencing uncovers novel miR-141-regulated molecular targets in PCa cells including the Rho GTPase

182 We provide an overview of the molecular targets in PDAC treatments, including targeted

183 vides new pharmacological content, including molecular targets in the malaria parasite, interaction d

184 animal PET to characterize the expression of molecular targets in the recently reported HD animal mod

185 gnal and can be used to quantitatively image molecular targets in tumours and to sensitively detect v

186 to identify actionable alterations, and thus molecular targets, in a patient.

187 Candidate molecular targets include seven single nucleotide polymo

188 Importantly, the complexity of molecular target interactions, such as protein-protein i

189 ure for DMD, and the identification of novel molecular targets involved in disease progression is imp

190 Accordingly, the molecular targets involved in formation and physiologica

191 ontinuous, real-time measurement of specific molecular targets (irrespective of their chemical reacti

192 nteraction between the GNPs and the intended molecular target is critical for the development of reli

193 Identifying a molecular target is essential for tumor-targeted nanomed

194 etic requisites of ligand binding toward its molecular target is of paramount relevance in drug desig

195 Molecular targeting is an import strategy to treat advan

196 to current therapies, identification of new molecular targets is essential.

197 Identification of molecular targets is important for the intervention and/

198 n balance in developing tissues via distinct molecular targets is only beginning to be understood.

199 does not prove, that binding to the unknown molecular target may be occurring through a covalent mec

200 ta with desired cell lines, tissue types, or molecular targets may not be readily interpretable or in

201 optical reporter images (e.g. labeled cells, molecular targets, microvasculature) of optically cleare

202 Therefore, relevant molecular targets need to be identified.

203 of particular interest because they are the molecular target of a number of pharmacological agents,

204 restingly, knockdown of ATGL, the best-known molecular target of ABHD5, impeded the proliferation and

205 methods, we identify phosphatidylserine as a molecular target of Apo-15.

206 lippase at the IM of mycobacteria and is the molecular target of BM212, a 1,5-diarylpyrrole compound.

207 ET-E, and TP1 (NACHT) domain of NLRP3 is the molecular target of diarylsulfonylurea inhibitors.

208 nctional and biophysical analyses reveal the molecular target of disulfiram's tumour-suppressing effe

209 the canonical autophagy pathway in DCs as a molecular target of Foxp3+ Treg-mediated suppression tha

210 3-P synthase (EPSPS) gene, which encodes the molecular target of glyphosate.

211 , depending upon the alkyl chain length, the molecular target of inhibition changes from mitochondria

212 ling evidence that Sec61alpha is the primary molecular target of ipomoeassin F and strongly suggests

213 -associated quality control and identify the molecular target of its activity.

214 Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphis

215 hese results identify wild-type NLRP3 as the molecular target of MCC950/CRID3 and show that CAPS-rela

216 ation of critical protein complexes, notably molecular target of rapamycin (mTOR) complex 1 (mTORC1).

217 One suggested molecular target of resveratrol is eukaryotic topoisomer

218 ipid-hydrolyzing activity of PLDalpha1, is a molecular target of RGS1.

219 A-type potassium channel Kv4.2 subunit is a molecular target of the GPR158-RGS7 complex.

220 transcription through Smoothened (Smo), the molecular target of the Hh pathway inhibitors used as ca

221 Caenorhabditis elegans BK channel SLO-1 as a molecular target of the Mel receptor PCDR-1-.

222 nt growth phenotype in PCa cells through its molecular targeting of AR and glucocorticoid receptor (G

223 ovalently functionalized with folic acid for molecular targeting of cancer cells.

224 Molecular targeting of proteins involved in the endosoma

225 Moreover, they introduce molecular targeting of SOX18 as a potential novel therap

226 Encapsulation and molecular targeting of therapeutic antibodies could beco

227 This article reviews platelet function, molecular targets of antiplatelet agents, and clinical i

228 plored common variants of genes representing molecular targets of coxibs for association with CAD.

229 In this study, we identified additional molecular targets of CTD using a Saccharomyces cerevisia

230 We now identify molecular targets of DHI in resistance vasculatures and

231 findings suggested that RyRs were sensitive molecular targets of DM with functional consequences lik

232 The molecular targets of ethanol toxicity during development

233 involving DDX41, STING, and other downstream molecular targets of L. monocytogenes-generated c-di-AMP

234 cid Type A (GABAA) receptors are the primary molecular targets of neurosteroid action, the structural

235 To identify molecular targets of oxaliplatin resistance in colorecta

236 model can thus be used to identify critical molecular targets of T cell dual-costimulation in the co

237 oteomics experiments and identify the direct molecular targets of the asparagusic acid tag.

238 dentify TRPM8 channels in sensory neurons as molecular targets of the immunosuppressant tacrolimus.

239 libraries of chemicals for interactions with molecular targets of the thyroid is now possible.

240 ays that identify chemical interactions with molecular targets of the thyroid system have been develo

241 germination, identifying EXPAs as downstream molecular targets of this developmental phase transition

242 receptor potential (TRP) cation channels are molecular targets of various natural products.

243 Screening molecular targets of water-soluble 3'-oxime ethers revea

244 l strategy and to the selection of CD38 as a molecular target on CLL cells, both consenting efficient

245 Therefore, examining molecular targets on this population of nociceptive fibe

246 Discovery of molecular targets or compounds that alter neuronal funct

247 In a case study, we showcase that multiple molecular targets predicted by AOPEDF are associated wit

248 ntibodies, each being specific for a desired molecular target, quantification of each molecular targe

249 it cannot be readily used to image specific molecular targets quantitatively inside live cells.

250 nomer sequence control confers potential for molecular targeting, recognition and biocatalysis, as we

251 The spectrum of known molecular targets recognized by Vdelta1-expressing gamma

252 Downstream molecular targets responsible for AHR-dependent adverse

253 modium parasite that causes malaria, but the molecular targets responsible for its parasite inhibitio

254 However, rarely have the specific underlying molecular targets responsible for these impacts been ide

255 underlying mechanism(s) of action nor their molecular target(s) are well defined.

256 However, the downstream molecular target(s) is unknown.

257 However, the molecular target(s) of PZQ remain undefined.

258 Identification of potential molecular targets specific to this population of fibers

259 tion of six different tumor types as well as molecular target statuses (such as MET or HER2-positive,

260 ctive for alpha9alpha10 nAChRs vs. all other molecular targets tested, including opioid and GABAB rec

261 for the exploration of the CYGB pathway as a molecular target that can be used to enhance the effecti

262 Our studies describe a molecular target that permits a combination of tumor abl

263 technology has been utilized for dissecting molecular targets that are important in certain cellular

264 like their human host, the number of unique molecular targets that can be exploited for antifungal d

265 biogenesis and homeostasis and are potential molecular targets that could be exploited for antibiotic

266 ies, position us to expand the assortment of molecular targets that could facilitate personalized tre

267 to identify the properties of particles and molecular targets that link exposure with specific biolo

268 ncers, highlighting the need to identify new molecular targets that modulate central downstream effec

269 this potential is predicated on identifying molecular targets that reverse the effects of aging in v

270 wworm's attraction to wounds, and identifies molecular targets that will aid in the development of od

271 A recent study has provided a new molecular target, the N-terminal acetyltransferase Naa10

272 t interact with them, and discuss actionable molecular targets, therapeutic agents in clinical transl

273 nical trials, STAT3 might be a candidate for molecular targeted therapies of SSc.

274 could form the basis for the development of molecular targeted therapies to improve clinical outcome

275 as chronic pain, which likely involves many molecular targets, this approach may identify novel trea

276 rker of postarrest brain injury as well as a molecular target to improve outcomes after CA.

277 s after burn injury and as a novel potential molecular target to improve the clinical outcome of seve

278 ns, and identifies Nav1.6 as a new potential molecular target to reduce excitability in patients with

279 rotective role of NLK in HD and reveal a new molecular target to reduce mHTT levels.

280 ings identify Ca(v)3.1 calcium channels as a molecular target to regulate autophagy and prevent progr

281 5 in resolving DNA and RNA G4s and suggest a molecular target to suppress MYC for cancer intervention

282 , confocal microscopy, and pharmacologic and molecular targeting to address these gaps in knowledge i

283 om-up and top-down approaches, building from molecular targets to behavioral analyses and vice versa,

284 receptor (PPAR) delta have been validated as molecular targets to counter NASH.

285 Such studies can help identify molecular targets to devise iron-related adjunctive ther

286 t measure chemical interactions with thyroid molecular targets to downstream events and adverse outco

287 esses specific markers, which can be used as molecular targets to facilitate drug delivery and imagin

288 ere currently are no validated biomarkers or molecular targets to predict or improve radiation respon

289 t facilitate the identification of tractable molecular targets to therapeutically promote neovascular

290 Molecular targeted treatments have improved LADC patient

291 vo experiments, we provide evidence that the molecular target underlying the thrombolytic effects of

292 protein (FAP) has emerged as an interesting molecular target used in the imaging and therapy of vari

293 is of renal function, tissue damage, and key molecular targets was performed.

294 Following exposure, structural and molecular targets were identified using live imaging of

295 ropose that the secreted AGR2 is a blockable molecular target, which acts as a chaperon-like enhancer

296 mics, we identified pirin as a high affinity molecular target, which was confirmed by SPR and crystal

297 ence endomicroscopy provides quick access to molecular targets, while Raman spectroscopy allows the d

298 e been previously studied, demonstrations of molecular targeting with such agents in live animals hav

299 ack luciferase-expressing tumor cells, image molecular targets with fluorescence probes, and to repor

300 These data identify key molecular targets within habenular cell types and provid