ライフサイエンスコーパス: monkeypox

1 eaks of emerging infectious diseases such as monkeypox.

2 ivo kinetics of T-cell responses in smallpox/monkeypox.

3 ne responses and vaccine-induced immunity to monkeypox.

4 s with confirmed and probable cases of human monkeypox.

5 , and outline the laboratory confirmation of monkeypox.

6 gnosis, current treatment, and prevention of monkeypox.

7 should have a low threshold for suspicion of monkeypox.

8 19, Singapore experienced a case of imported monkeypox.

9 agent of mpox, a zoonosis formerly known as monkeypox.

10 x and other zoonotic Orthopoxviruses such as monkeypox.

11 ho was initially suspected of infection with monkeypox.

12 Of 3 family members with monkeypox, 2 had rash illness only, and 1 required hospi

13 In July, 2022, WHO declared monkeypox a Public Health Emergency of International Con

14 Human mpox (monkeypox), a disease with similarities to smallpox, is

15 immunologically most similar to smallpox is monkeypox, a zoonosis endemic to moist forested regions

16 , e.g., coronavirus disease 2019 (COVID-19), monkeypox, abortion misinformation, climate change, and

17 Our analysis of monkeypox also clarifies the various ways that imperfect

18 promised the Dryvax-induced immunity against monkeypox, although the covaccinated monkeys exhibited m

19 a bioweapon and the emerging threat of human monkeypox, among other poxviral diseases, highlight the

20 ariola, the causative agent of smallpox, and monkeypox, an emerging virus of great concern for human

21 ng its performance on external data sets for monkeypox and COVID-19.

22 se other orthopoxviruses, including variola, monkeypox and cowpox viruses, encode orthologues of F14.

23 se other orthopoxviruses, including variola, monkeypox and cowpox viruses, encode orthologues of F14.

24 such as human immunodeficiency virus (HIV), monkeypox and severe acute respiratory syndrome (SARS) w

25 gens, which includes the causative agents of monkeypox and smallpox.

26 pler, safer, and more effective vaccines for monkeypox and smallpox.

27 hat includes the human pathogens variola and monkeypox and the vaccine species vaccinia virus.

28 activity against orthopox viruses (smallpox, monkeypox, and cowpox virus) of the synthesized nucleosi

29 V) elicits heterotypic immunity to smallpox, monkeypox, and mousepox, the mechanistic basis for which

30 hemagglutinin (HA) gene in camelpox, cowpox, monkeypox, and vaccinia viruses.

31 Neutralization titers to vaccinia, monkeypox, and variola major were assessed and cell-medi

32 to multiple poxviruses, including vaccinia, monkeypox, and variola major, and broad T-cell responses

33 ected in the throat, tonsil, and spleen, and monkeypox antigen was detected in the lung, hilar and su

34 Monkeypox belongs to the Orthopoxvirus genus of the Poxv

35 virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised i

36 uses, including vaccinia, rabbitpox, cowpox, monkeypox, camelpox and variola viruses, deploy counterm

37 ultiple orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and

38 poxviruses (OPV): variola, vaccinia, cowpox, monkeypox, camelpox, ectromelia, and taterapox viruses.

39 entification and differentiation of variola, monkeypox, camelpox, vaccinia, and cowpox virus species

40 tive antiviral immunity against West African monkeypox can potentially be maintained for decades afte

41 and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related noso

42 Israel, and Singapore became the first human monkeypox cases exported from Africa, and a related noso

43 ctive review of hospital records of 40 human monkeypox cases from Nigeria, the majority developed fev

44 ovember 2007, 760 laboratory-confirmed human monkeypox cases were identified in participating health

45 f non-endemic countries reported hundreds of monkeypox cases, most with no epidemiological link to Af

46 In our cohort, monkeypox caused genital, perianal, and oral lesions and

47 Monkeypox causes a characteristic skin eruption and muco

48 d offers protection from a highly pathogenic monkeypox challenge.

49 For the 2022 multinational monkeypox clade IIb virus outbreak, we developed a 7-ite

50 keys exhibited measurable protection against monkeypox compared to that of naive controls.

51 es, and most mammalian poxviruses, including monkeypox, cowpox, and ectromelia.

52 on-Variola orthopoxvirus isolates, including monkeypox, cowpox, and vaccinia viruses, for rapid detec

53 s variola major virus, camelpox, buffalopox, monkeypox, cowpox, and variola minor viruses.

54 As demonstrated for monkeypox data from the Democratic Republic of Congo, th

55 ng recent outbreaks of cutaneous anthrax and monkeypox demonstrate the importance of dermatologist pr

56 lustrate a spectrum of clinical illness with monkeypox despite a common source of exposure; manifesta

57 l July 13, 2022.181 patients had a confirmed monkeypox diagnosis and were enrolled in the study.

58 [(18)F]-fluorodeoxyglucose (FDG) can monitor monkeypox disease progression in vivo in nonhuman primat

59 munity which can protect against Variola and Monkeypox disease.

60 activation that may allow risk assessment of monkeypox disease.

61 alyzed human monkeypox incidence trends in a monkeypox-enzootic region.

62 whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release o

63 than 30,000 cases of mpox (formerly known as monkeypox) had occurred as of March 1, 2023, in an outbr

64 Available small animal models of human monkeypox have been restricted to mammals with poorly de

65 s such as coronavirus disease (COVID-19) and monkeypox have raised the paradigm of 5(th) generation p

66 fer hope for the treatment and prevention of monkeypox; however, more research must be done before th

67 dicate that route of infection can influence monkeypox illness manifestations.

68 that a subunit vaccine approach to smallpox-monkeypox immunization is feasible.

69 We describe a cluster of monkeypox in a family with a spectrum of clinical illnes

70 A case of monkeypox in a health-care worker in the UK in 2018 was

71 In addition, sporadic outbreaks of human monkeypox in Africa and a recent outbreak of human monke

72 However, unprecedented outbreaks of monkeypox in non-endemic regions have recently taken the

73 ntified three previously unreported cases of monkeypox in preimmune individuals at 13, 29 and 48 year

74 The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC)

75 Studies on the burden of human monkeypox in the Democratic Republic of the Congo (DRC)

76 The outbreak of monkeypox in the Midwestern United States during June 20

77 pox in Africa and a recent outbreak of human monkeypox in the U.S. have made it clear that naturally

78 e virus, and the discovery of human cases of monkeypox in the United States.

79 The outbreak of monkeypox in the Unites States in the summer of 2003 was

80 tensity for 'mpox' was higher than that for 'monkeypox' in locations with greater LGBTQ + acceptance

81 We report that monkeypox, in addition to causing febrile rash illness,

82 smallpox vaccination campaigns ceased, human monkeypox incidence has dramatically increased in rural

83 Analysis of the instantaneous growth rate of monkeypox incidence indicates that the epidemic peaked i

84 current risk of infection, we analyzed human monkeypox incidence trends in a monkeypox-enzootic regio

85 10,000) suggests a 20-fold increase in human monkeypox incidence.

86 the early pathogenic events of inhalational monkeypox infection in NHPs were characterized, and the

87 resent study, the early pathogenic events of monkeypox infection in nonhuman primates, a surrogate fo

88 events occurring in an inhalational macaque monkeypox infection model, supporting its use as a surro

89 Previously, the later stages of monkeypox infection were defined, but the early course o

90 New clinical presentations of monkeypox infection were identified, including rectal pa

91 d >or=90% specificity for detecting clinical monkeypox infection, we identified three previously unre

92 th drugs have also been recommended to treat monkeypox infection.

93 the degree of age-specific immunity against monkeypox, influenza A(H5N1) and A(H7N9), and refined ex

94 The monkeypox inhibitor of complement enzymes (MOPICE), whic

95 d a virulence factor expressed by monkeypox (monkeypox inhibitor of complement enzymes or MOPICE).

96 cines protect healthy macaques from a lethal monkeypox intravenous challenge, our data identify LC16m

97 Monkeypox is a viral zoonotic disease endemic in Central

98 Monkeypox is a zoonotic illness caused by the monkeypox

99 Human monkeypox is a zoonotic Orthopoxvirus with a presentatio

100 n fatalities, this outbreak illustrates that monkeypox is an emerging natural infection and a potenti

101 Monkeypox is an emerging virus initially isolated in 195

102 Monkeypox is an emerging zoonosis endemic to Central and

103 in orthopoxvirus infection.IMPORTANCE Human monkeypox is an emerging zoonotic infectious disease cau

104 Human monkeypox is an endemic disease in rain-forested regions

105 Human monkeypox is considered an emerging zoonotic infectious

106 Monkeypox is endemic in regions of western and central A

107 Mpox (formerly known as monkeypox) is a zoonotic viral disease endemic in parts

108 of the level of genetic variation present in monkeypox isolates circulating within the contiguous reg

109 on/management of bacterial superinfection in monkeypox keratitis.

110 lement inhibitors of smallpox, vaccinia, and monkeypox known as SPICE, VCP (or VICE), and MOPICE, res

111 In this case series, monkeypox manifested with a variety of dermatologic and

112 levant to monkeypox, though complications of monkeypox may be rarer and perhaps less severe.

113 accine to protect people against smallpox, a monkeypox model of infection in cynomolgus macaques, whi

114 haracterized a virulence factor expressed by monkeypox (monkeypox inhibitor of complement enzymes or

115 in less than 5% of patients with human mpox (monkeypox), most commonly presenting with self-limiting

116 the world still vividly recalls the previous monkeypox (mpox) outbreak that impacted over 120 countri

117 However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a dif

118 Historically, monkeypox (mpox) was a zoonotic disease endemic in Afric

119 Monkeypox (Mpox), a zoonotic illness triggered by the mo

120 During the 2022 monkeypox (MPX) outbreak, testing has been limited and r

121 and projected future distributions of human monkeypox (MPX).

122 Monkeypox (MPXV) and cowpox (CPXV) are emerging agents t

123 lpox, cowpox, ectromelia, gerbilpox, herpes, monkeypox, myxoma, rabbitpox, raccoonpox, skunkpox, vacc

124 nity transmission of mpox (formerly known as monkeypox) notified WHO of new mpox cases.

125 engendered during eradication efforts, could monkeypox now gain a foothold in human communities?

126 In April 2003, an outbreak of monkeypox occurred in the United States following the im

127 t global outbreak of mpox (formerly known as monkeypox) occurred.

128 Monkeypox ophthalmic manifestations may present to the o

129 hesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R

130 The largest West African monkeypox outbreak began September 2017, in Nigeria.

131 smallpox-based bioterrorist event or a human monkeypox outbreak has heightened the importance of new,

132 pidemiological features of the 2017-18 human monkeypox outbreak in Nigeria.

133 The US monkeypox outbreak of 2003 provided the opportunity to e

134 Together, this shows that the US monkeypox outbreak was larger than previously realized a

135 In the current monkeypox outbreak, vaccination and treatment of pregnan

136 accinia strains being tested for variola and monkeypox prevention and for the delivery of heterologou

137 BN) vaccination is approved for smallpox and monkeypox prevention, immunological persistence and boos

138 Countermeasures for mpox (formerly known as monkeypox), primarily vaccines, have been in limited sup

139 In September, 2017, human monkeypox re-emerged in Nigeria, 39 years after the last

140 rch areas related to mpox (formerly known as monkeypox) reflect the need for STI-related research dur

141 Monkeypox-related ophthalmic disease (MPXROD) includes a

142 s ago; orthopox viruses such as smallpox and monkeypox remain serious public health threats both thro

143 other related pathogenic poxviruses, such as monkeypox, remain potential bioterrorist weapons or coul

144 oxvirus infection, such as human smallpox or monkeypox, remain to be fully identified.

145 epidemiologic limitations that could impede monkeypox's emergence as a significant pathogen of human

146 Monkeypox should be considered in high-risk populations

147 The virus was identified by detection of monkeypox-specific DNA sequences in tissues or isolates

148 cinated persons had a 5.2-fold lower risk of monkeypox than unvaccinated persons (0.78 vs. 4.05 per 1

149 d clinical characteristics of cases of human monkeypox that occurred between Sept 22, 2017, and Sept

150 gation form, with a case definition of human monkeypox that was based on previously established guide

151 worldwide outbreak of mpox (formerly called monkeypox) that resulted in an international public heal

152 including the COVID-19 vaccine for children, Monkeypox, the adult COVID-19 booster, the HIV vaccine,

153 complications of smallpox may be relevant to monkeypox, though complications of monkeypox may be rare

154 om became the first confirmed human-to-human monkeypox transmission event outside of Africa.

155 UK became the first confirmed human-to-human monkeypox transmission event outside of Africa.

156 x viruses, as well as those such as variola, monkeypox, vaccinia, and camelpox viruses, which do not.

157 omolgus macaques were exposed to aerosolized monkeypox virus (10(5) PFU).

158 reexpansion in association with sterile anti-monkeypox virus (anti-MPV) immunity after MPV challenge.

159 Monkeypox virus (MPV) is a virulent human pathogen that

160 Monkeypox virus (MPV) is an orthopox virus in the Poxvir

161 monstrate that the Poxviridae family members monkeypox virus (MPX) and variola virus (VarV) use conse

162 In this review, 50 questions regarding monkeypox virus (MPXV) and the current MPX outbreak were

163 cted on surface carriers inoculated with the monkeypox virus (MPXV) by applying six disinfectant solu

164 Infection with monkeypox virus (MPXV) causes disease manifestations in

165 ria in 2019-2020 reveal multiple lineages of monkeypox virus (MPXV) co-circulated in humans for sever

166 Here we determined the apo structure of monkeypox virus (MPXV) Core(Pro) and the structure of Co

167 Monkeypox virus (MPXV) disease has been declared a publi

168 While the monkeypox virus (MPXV) genome encodes a homologue of the

169 On May 6, 2022, a powerful outbreak of monkeypox virus (MPXV) had been reported outside of Afri

170 Monkeypox virus (MPXV) has been linked to vertical trans

171 Monkeypox virus (MPXV) has recently caused a global dise

172 ivity has been associated with the spread of monkeypox virus (MPXV) in the ongoing, global 2022 epide

173 In early 2022, a cluster of monkeypox virus (MPXV) infection (mpox) cases were ident

174 Monkeypox virus (MPXV) infection has recently expanded i

175 Mpox, caused by monkeypox virus (MPXV) infection, has emerged as a signi

176 Monkeypox virus (MPXV) infections in humans cause neurol

177 A global outbreak of clade IIb Monkeypox virus (MPXV) infections spread rapidly across

178 Monkeypox virus (MPXV) is a human pathogen that is a mem

179 Monkeypox virus (MPXV) is a poxvirus endemic to Central

180 Monkeypox virus (MPXV) is a reemerging virus of global c

181 Monkeypox virus (MPXV) is an orthopoxvirus closely relat

182 Monkeypox virus (MPXV) is an orthopoxvirus closely relat

183 Infection of nonhuman primates (NHPs) with monkeypox virus (MPXV) is currently being developed as a

184 Monkeypox virus (MPXV) is endemic in Africa, where it ca

185 Monkeypox virus (MPXV) is endemic in western and Central

186 Monkeypox virus (MPXV) is endemic within Africa where it

187 Monkeypox virus (MPXV) is genetically structured in 2 ma

188 Monkeypox virus (MPXV) is the causative agent of mpox, a

189 nd clinical data associated with 18 cases of monkeypox virus (MPXV) isolated from 19 clinical samples

190 The 2003 monkeypox virus (MPXV) outbreak and subsequent laborator

191 Monkeypox virus (MPXV) poses a global health emergency,

192 mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166,

193 To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in hum

194 facing a second wave of infections from the monkeypox virus (MPXV), characterized by an exponential

195 Monkeypox virus (MPXV), originally characterized in the

196 (Mpox), a zoonotic illness triggered by the monkeypox virus (MPXV), poses a significant threat since

197 Mpox disease, caused by the monkeypox virus (MPXV), remains a global health concern

198 Monkeypox virus (MPXV), which causes disease in humans,

199 ox, that protected nonhuman primates against monkeypox virus (MPXV)-induced severe disease.

200 e United States following the importation of monkeypox virus (MPXV)-infected animals in a consignment

201 erging zoonotic infectious disease caused by Monkeypox virus (MPXV).

202 on of A29 which is the target protein of the monkeypox virus (MPXV).

203 irus (NVO) or confirmed positive for NVO and Monkeypox virus (MPXV).

204 elting temperature [T(m)], 56.40 degrees C), monkeypox virus (T(m), 56.24 degrees C), and vaccinia vi

205 (m)s, 61.7 to 62.7 degrees C), 15 strains of monkeypox virus (T(m)s, 61.9 to 62.2 degrees C), 40 stra

206 lid swelling and developed skin lesions from monkeypox virus 2 days later.

207 lymerase chain reaction on a rectal swab for Monkeypox virus after a recent trip to Brazil, where he

208 us Ankara (MVA) is used as a vaccine against monkeypox virus and as a viral vaccine vector.

209 r.IMPORTANCE Several OPXV species, including monkeypox virus and cowpox virus, cause zoonotic infecti

210 uspected mpox, 31 of which were positive for monkeypox virus and were included in our analysis (four

211 causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposef

212 The prairie dog, using monkeypox virus as a challenge virus, has provided a val

213 macaques were challenged intravenously with monkeypox virus at 4, 6, 10, and 30 days after immunizat

214 e macaques were not protected against lethal monkeypox virus challenge if their CD4(+) cell count was

215 th MVA provided protection for >2 years in a monkeypox virus challenge model.

216 us compound ST-246 in prairie dogs against a monkeypox virus challenge of 65 times the 50% lethal dos

217 Recent monkeypox virus challenge studies have established the b

218 could be boosted as a recall response after monkeypox virus challenge.

219 Monkeypox virus clade I is endemic in several central Af

220 eactivity with orthopox viruses and specific monkeypox virus detection with MPXV.

221 Monkeypox virus DNA was detected by PCR from vaginal swa

222 Monkeypox virus DNA was detected in 29 of the 32 persons

223 odeoxyglucose ([(18)F]-FDG) in monkeys after monkeypox virus exposure to monitor the immune response

224 ocuments the isolation and identification of monkeypox virus from humans in the Western Hemisphere.

225 All new and already published monkeypox virus genomes from the Central African Republi

226 ies outside of Africa, despite the fact that monkeypox virus has been causing disease in parts of Afr

227 022, the world was alerted to circulation of monkeypox virus in many high-income countries outside of

228 Our results suggest endemicity of monkeypox virus in Nigeria, with some evidence of human-

229 ain reaction and culture revealed infectious monkeypox virus in skin lesions of all 3 patients; 2 pat

230 5% CrI: 55.78, 86.85) of infections with the monkeypox virus in the UK were captured over the outbrea

231 ed a valuable nonhuman animal model in which monkeypox virus infection closely resembles human system

232 nd November, 2022, global outbreaks of human monkeypox virus infection have been reported in more tha

233 Before April 2022, monkeypox virus infection in humans was seldom reported

234 Monkeypox virus infection of nonhuman primates (NHPs) pr

235 Monkeypox virus infection results in a systemic, febrile

236 locations with high numbers of diagnoses of monkeypox virus infection were approached and invited to

237 ted data for a total of 136 individuals with monkeypox virus infection who presented between May 11 a

238 One year after monkeypox virus infection, 6 of 7 individuals had IFN- g

239 ted with VV, 7 individuals with a history of monkeypox virus infection, and 8 individuals with a hist

240 s in people with HIV, including COVID-19 and monkeypox virus infection.

241 en and non-binary individuals with confirmed monkeypox virus infection.

242 An outbreak of monkeypox virus infections in non-endemic countries was

243 Understanding the mechanisms of monkeypox virus innate immune evasion will help us to un

244 Subsequent monkeypox virus intranasal infection of vaccinated prair

245 Monkeypox virus is a less efficient human pathogen than

246 Monkeypox virus is an emerging, zoonotic orthopoxvirus w

247 Monkeypox virus is an Orthopoxvirus (genus includes vari

248 Monkeypox virus is believed to be predominantly transmit

249 Clade I monkeypox virus is endemic in DR Congo.

250 uses smallpox) is the most pathogenic, while monkeypox virus is intermediate in pathogenicity between

251 Here, we report that cross-reactive monkeypox virus neutralizing antibodies were detectable

252 An ongoing global monkeypox virus outbreak in 2022 includes the US and oth

253 ys: RealStar Orthopoxyvirus PCR and FlexStar Monkeypox virus PCR (Altona Diagnostics), Novaplex MPXV

254 r limit of detection was 200 copies/mL using monkeypox virus plasmids in pooled UTM matrix.

255 agnostics), Novaplex MPXV (Seegene), VIASURE Monkeypox virus Real Time PCR Reagents (CerTest Biotec),

256 equences from this study clustering with two monkeypox virus sequences from the current DR Congo outb

257 Monkeypox virus sequences were obtained and analysed usi

258 d from the coronavirus, the emergence of the monkeypox virus signaled a potential new pandemic, highl

259 lScheme to develop a primer scheme for human monkeypox virus that can be used with many sequencing an

260 rowth rates of cases by reporting date, when monkeypox virus was confirmed and reported to UKHSA, wer

261 Monkeypox virus was recovered in cell cultures of seven

262 People infected with monkeypox virus were aged between 2 days and 50 years (m

263 In May 2022, individuals infected with the monkeypox virus were detected in the UK without clear tr

264 Individuals who tested positive for monkeypox virus were from Cuvette-Centrale (19 [61%] of

265 enetic constrains are sufficient to diminish monkeypox virus' capacity for enhanced specificity as a

266 revented spread of vaccinia virus as well as monkeypox virus, a human pathogen.

267 re essential for protection of macaques from monkeypox virus, a variola virus ortholog.

268 onkeypox is a zoonotic illness caused by the monkeypox virus, an Orthopoxvirus in the same genus as t

269 thogenic orthopoxviruses like variola virus, monkeypox virus, and cowpox virus (CPXV), but not vaccin

270 (HSV-2), human immunodeficiency virus (HIV), monkeypox virus, and hepatitis B virus.

271 accinia virus, the emerging infectious agent monkeypox virus, and the potential biothreat variola vir

272 r both, and the experiences with SARS-CoV-2, monkeypox virus, and Zika virus highlight the feasibilit

273 ception, exhibiting extreme vulnerability to monkeypox virus, cowpox virus, and vaccinia virus and th

274 Clade Ib, a new strain of clade I monkeypox virus, emerged in eastern DR Congo, sparking a

275 Mpox, caused by the monkeypox virus, is a serious public health threat in Af

276 Given the evolving nature of the monkeypox virus, ongoing research and strong public heal

277 nt of smallpox (variola virus), the zoonotic monkeypox virus, the vaccine and zoonotic species vaccin

278 After challenge with monkeypox virus, unimmunized animals developed more than

279 an transmission of the west African clade of monkeypox virus.

280 olog was maintained in many OPXVs, including monkeypox virus.

281 ion from a lethal intravenous challenge with monkeypox virus.

282 a, vaccinia, camelpox, mousepox, cowpox, and monkeypox virus.

283 an outbreak of the west African clade of the monkeypox virus.

284 d new and emerging infectious agents such as monkeypox virus.

285 ase after an otherwise lethal challenge with monkeypox virus.

286 d 94.1% sensitivity and 100% specificity for monkeypox virus.

287 mpox, a disease caused by infection with the monkeypox virus.

288 feared but now eradicated virus, as well as monkeypox virus.

289 une regime (69 U/ml) prior to challenge with monkeypox virus.

290 Cowpox and monkeypox viruses have taken an alternate approach by en

291 protein (OMCP) is conserved among cowpox and monkeypox viruses, secreted by infected cells, and bound

292 uring human infections with the smallpox and monkeypox viruses, which are highly homologous to ectrom

293 % identity in all orthopoxviruses except for monkeypox viruses, whose O3 homologs have 2 to 3 amino a

294 ly conserved in most, including smallpox and monkeypox viruses.

295 o 7.08) on the 6 May, when the first case of monkeypox was reported in the UK, to a halving time of 2

296 a global outbreak of mpox (formerly known as monkeypox) was reported outside of areas considered ende

297 122 confirmed or probable cases of human monkeypox were recorded in 17 states, including seven de

298 an countries reported autochthonous cases of monkeypox, which rapidly spread globally.

299 Monkeypox, with associated encephalitis, occurred in the

300 us agents, such smallpox or a related virus, monkeypox, would have catastrophic consequences.