ライフサイエンスコーパス: monocyte-derived DC

1 forms a negative feedback loop with Cebpb, a monocyte-derived DC epigenetic fate-determining TF.

2 eumovax and Gardasil, respectively, activate monocyte-derived DCs, monocytes and CD1c+ blood DCs, hig

3 Activated monocyte-derived DCs express Notch ligands Jagged1 and D

4 primed with allogeneic CD40 ligand-activated monocyte-derived DCs (DC1) differentiated into CD8 T cel

5 of TNF production by human newborn and adult monocyte-derived DCs cultured in 10% autologous plasma o

6 oducing T cells, but only partially affected monocyte-derived DC numbers.

7 Although monocyte-derived DCs and cDC2s can cross-present in vitr

8 Although monocyte-derived DCs did not efficiently crosspresent fr

9 Although monocyte-derived DCs exhibited greater fluid-phase uptak

10 Both BDCA3(+) and monocyte-derived DC-SIGN(+) NP-loaded DCs were equally e

11 nnate immune cells composed of classical and monocyte-derived DC, Langerhans cells, and plasmacytoid

12 onocytes, myeloid dendritic cells (mDC), and monocyte-derived DC (MO-DC) expressed IL-36R and respond

13 e observed that the DEP-induced monocyte and monocyte-derived DC recruitment was completely abolished

14 ased differed among blood DC, monocytes, and monocyte-derived DC, and other immune cell types.

15 d Ly-6C expression, highlighting mucosal and monocyte-derived DC lineages.

16 In human BDCA1+ and monocyte-derived DCs, CD40 and mannose receptor targeted

17 is upregulated upon activation of BMDCs and monocyte-derived DCs, restrains migration of skin and BM

18 -derived DCs, and lung-resident CD11b(+) and monocyte-derived DCs, whereas intestinal and pulmonary C

19 GM-CSF induced the recruitment of CD11b+ and monocyte-derived DCs.

20 tion (CD) 11b(+) conventional DCs (cDCs) and monocyte-derived DCs, LP CD103(+), and CD11b(+) cDCs but

21 THP-1 cells and monocyte-derived DCs (MDDCs) were investigated as a mode

22 ted 293 cell, IDO+ ovarian cancer cells, and monocyte-derived DCs on CD4+ Th1 cells, CD8+ T cells, an

23 whereas early induction of Th1 cytokines and monocyte-derived DCs are features of successful activati

24 ha (TNF-alpha) production by myeloid DCs and monocyte-derived DCs.

25 ected human DC-SIGN(+/-) Raji cell lines and monocyte-derived DCs (MoDCs) were pulsed with whole, liv

26 lls (DCs), as well as in human APC lines and monocyte-derived DCs.

27 contrast to the effects on bone marrow- and monocyte-derived DCs, the current study shows that Ad in

28 nse to acute exposure to DEPs, monocytes and monocyte-derived DCs accumulated in the lungs of WT mice

29 etion of Ly6C(hi) inflammatory monocytes and monocyte-derived DCs enhanced NP-specific IgM and IgG3 r

30 )-mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene

31 ltrated the epidermis, whereas monocytes and monocyte-derived DCs were predominant in the dermis.

32 gly up-regulated in stimulated monocytes and monocyte-derived DCs, persisting in the latter for much

33 Using primary T(CD4+)s and monocyte-derived DCs from healthy donors, we show that a

34 t tumor and viral antigens in vitro than are monocyte-derived DCs (moDCs).

35 Among these are monocyte-derived DCs (moDCs) and monocyte-derived macrop

36 dendritic cells (DCs), often referred to as monocyte-derived DCs or inflammatory DCs (iDCs), conside

37 Four clinical-grade autologous monocyte-derived DC vaccines were prepared after a singl

38 inflammatory DCs and the distinction between monocyte-derived DCs and macrophages is less clear.

39 ession levels of cytosolic proteases between monocyte-derived DCs and MPs and upon maturation with LP

40 We separately generated blood monocyte-derived DCs (moDCs), as well as Langerhans cell

41 ly downregulated in Mtb-infected human blood monocyte-derived DCs, indicating that reduction of annex

42 vation by TLR agonists in inflammatory blood monocyte-derived DCs that express inducible NO synthase.

43 re the closest known equivalent of the blood monocyte-derived DCs that have been used for human thera

44 Bovine monocyte-derived DC (moDC) were exposed to integrin-bind

45 ndocytosis, and intracellular degradation by monocyte-derived DC (mdDC).

46 We also studied LP cross-presentation by monocyte-derived DC, plasmacytoid DC, monocytes, and B c

47 to high and sustained cross-presentation by monocyte-derived DC.

48 gs show that B. miyamotoi is phagocytosed by monocyte-derived DCs, causing upregulation of activation

49 amma was required for IL-12p70 production by monocyte-derived DCs from SzS.

50 CCR7 and CCR8 pathways were used by monocyte-derived DCs during mobilization from skin to LN

51 In this study, we revealed that CCR2(+) monocyte-derived DCs (moDCs), but not conventional DCs,

52 potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.

53 monocytes fail to differentiate into CD1a(+) monocyte-derived DCs.

54 +)Ly6C(+) and CD11c(+)CD11b(+)Ly6C(-)CD64(+) monocyte-derived DCs was reduced in Clec4n(-/-) recipien

55 eas in CM, CD103- cDC2s, CD103+ type 1 cDCs, monocyte-derived DCs, and plasmacytoid DCs were signific

56 lymph nodes more efficiently than classical monocyte-derived DCs.

57 ontrol or vitamin (Vit) D3/IL-10-conditioned monocyte-derived DC.

58 VitD3/IL-10-conditioned, monocyte-derived DC were resistant to maturation and fai

59 In contrast, monocyte-derived DCs did not respond to CpG, but they we

60 Like conventional monocyte-derived DC, designated mDC1, mDC2 expressed hig

61 fect is specific to cDCs, as Rab43-deficient monocyte-derived DCs showed no defect in cross-presentat

62 affected, whereas alpha4 integrin-deficient, monocyte-derived DCs accumulated less efficiently in the

63 deficient in CD103(+) DCs and CCR2-dependent monocyte-derived DCs exhibited similar allergic inflamma

64 studied endogenous mechanisms in developing monocyte-derived DCs (MoDCs) that can induce inflammator

65 We now show that fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIG

66 nitiate the immune response in this disease, monocyte-derived DCs were generated from coccidioidal Ag

67 In vitro, HIV Nef drives monocyte-derived DCs toward BLyS overexpression through

68 To identify naturally processed epitopes, monocyte-derived DC were pulsed with preproinsulin (PPI)

69 RegDC generated from monocyte-derived DC treated either with LPS and dexameth

70 gammaRI, distinguishes conventional DCs from monocyte-derived DCs (Mo-DCs).

71 arrow culture protocols efficiently generate monocyte-derived DCs or produce a mixture of FLT3L-depen

72 toid, and myeloid DCs and in vitro generated monocyte-derived DCs of healthy blood donors.

73 and were internalized by in vitro-generated monocyte-derived DCs (moDCs) and macrophages and by ex v

74 Consistently, in vitro-generated monocyte-derived DCs pulsed with Porphyromonas gingivali

75 To address this, we generated monocyte-derived DCs (MDDCs) in vitro which phenotypical

76 In mice, lymph node-homing monocyte-derived DCs processed Ags from engulfed cells a

77 Here, we demonstrate that human monocyte derived DCs (moDCs) support productive viral re

78 Human monocyte-derived DC were infected by wild-type (wt) EBOV

79 teristics shared between our cells and human monocyte-derived DC, whose analogues in mice have not be

80 ween murine cytomegalovirus (MCMV) and human monocyte-derived DC.

81 ukocyte antigen (HLA)-DR expression by human monocyte-derived DC, 3 relevant molecules for Th-cell ge

82 Here we show that immature human monocyte-derived DC capture various killed tumor cells,

83 markedly increased IL-23 secretion in human monocyte-derived DC and freshly isolated myeloid DC.

84 nalyzed the induction of maturation in human monocyte-derived DC following exposure to GAS clinical i

85 cellular and extracellular response in human monocyte-derived DC, especially during the monocyte to D

86 hat IFX aggregates were able to induce human monocyte-derived DC (moDC) maturation in a concentration

87 ncapsulated C. gattii failed to induce human monocyte-derived DC maturation and T cell proliferation,

88 ow that Ebola and Lassa viruses infect human monocyte-derived DC and impair their function.

89 ects of CT and LT on the maturation of human monocyte-derived DC (MDDC) in vitro.

90 with the maturation and/or function of human monocyte-derived DC.

91 sufficient to strongly impair primary human monocyte-derived DC (MDDC) responses upon stimulation in

92 We demonstrate that human monocyte-derived DC are permissive to Ad infection at mu

93 Human monocyte-derived DCs (moDCs) and circulating conventiona

94 epatoma cells is capable of activating human monocyte-derived DCs by up-regulating the expression of

95 We show that, after human monocyte-derived DCs were infected with virulent Mycobac

96 s of mouse bone marrow-derived DCs and human monocyte-derived DCs in vitro.

97 sistent with this, VLDLR expression by human monocyte-derived DCs was increased by HDM stimulation.

98 efficiently bound and internalized by human monocyte-derived DCs, trafficked to late phagolysosomes,

99 dy, we report that serum-free cultured human monocyte-derived DCs after TLR stimulation with polyinos

100 CRISPR-Cas9 genome editing method for human monocyte-derived DCs (moDCs) that mediates knockouts wit

101 e used to compare whole proteomes from human monocyte-derived DCs differentiated toward either regula

102 ive and -nonreceptive populations from human monocyte-derived DCs.

103 We have found that mature, immunogenic human monocyte-derived DCs (moDCs) up-regulate the immune-inhi

104 henotypic and functional maturation in human monocyte-derived DCs (MDDCs) similar to but distinct fro

105 that ET induces a maturation state in human monocyte-derived DCs (MDDCs) similar to that induced by

106 to selectively activate PKA or Epac in human monocyte-derived DCs and examined the effect of these si

107 ne markers differentially expressed in human monocyte-derived DCs differentiated toward a proallergic

108 Activation of FPR3 in human monocyte-derived DCs leads to inhibition of IL-12 produc

109 ession of DC-SCRIPT and GR is shown in human monocyte-derived DCs, and DC-SCRIPT knockdown enhances G

110 valent mechanisms were demonstrated in human monocyte-derived DCs, setting the scene for a possible r

111 in regulation of IL-12p40 secretion in human monocyte-derived DCs.

112 tion to that of adenosine signaling in human monocyte-derived DCs.

113 ant factor for DC-SCRIPT expression in human monocyte-derived DCs.

114 ll-like receptor-4 (TLR-4) ligation in human monocyte-derived DCs.

115 tins modulate the TLR4-AhR-IDO axis in human monocyte-derived DCs.

116 somal recycling compartments (ERCs) in human monocyte-derived DCs.

117 while decreasing IL-12p40 secretion in human monocyte-derived DCs.

118 2 and ATG16L1 using common variants in human monocyte-derived DCs.

119 mature murine DCs was also observed in human monocyte-derived DCs.

120 sults demonstrated that tumour-induced human monocyte-derived DCs exhibited systematic functional def

121 In the current study, we infected human monocyte-derived DCs with C. jejuni to examine the produ

122 96-well in vitro assays using neonatal human monocyte-derived DCs and humanized TLR8 mouse bone marro

123 immune reaction during the response of human monocyte-derived DCs (mDCs) to different TLR stimuli: LP

124 nhibition on LPS-induced maturation of human monocyte-derived DCs (Mo-DCs).

125 saccharide (LPS)-induced maturation of human monocyte-derived DCs (MoDCs) in vitro.

126 We compared the abilities of human monocyte-derived DCs and DCs derived in vitro from CD34-

127 ellular dsDNA is a potent activator of human monocyte-derived DCs as well as primary DCs.

128 nts the T-cell stimulatory capacity of human monocyte-derived DCs in the presence of Treg.

129 that IFN-beta1a in vitro treatment of human monocyte-derived DCs induced the expression of TLR7 and

130 Direct contact of human monocyte-derived DCs with an inflamed, TNF-alpha-stimula

131 e, we demonstrate that on infection of human monocyte-derived DCs with herpes simplex virus type 1 (H

132 of IL-10 during in vitro maturation of human monocyte-derived DCs with ischemia/reperfusion-associate

133 onal antibodies leads to maturation of human monocyte-derived DCs, which depends on the presence of I

134 phenotype, function, and migration of human monocyte-derived DCs.

135 henotypic and functional maturation of human monocyte-derived DCs.

136 report that eATP induced maturation of human monocyte-derived DCs.

137 ine bone marrow-derived DCs (BMDCs) or human monocyte-derived DCs (HDCs) were incubated with live, en

138 In parallel, human monocyte-derived DCs stimulated in vitro with live H. py

139 in LPS-stimulated PWD DCs phenocopying human monocyte-derived DCs.

140 I inhibition were delivered to primary human monocyte-derived DCs (MDDCs) using a lentivirus-based ex

141 in the stimulatory capacity of primary human monocyte-derived DCs infected with wild-type DENV isolat

142 , we show that AMPK activation renders human monocyte-derived DCs tolerogenic as evidenced by an enha

143 In this study, we show that human monocyte-derived DCs constitutively express significant

144 d the binding of targeted liposomes to human monocyte-derived DCs (Mo-DCs), demonstrating their targe

145 ovide activation/maturation signals to human monocyte-derived DCs.

146 les (VRPs) for in vitro Ag delivery to human monocyte-derived DCs.

147 he role of DDR1 in DC maturation using human monocyte-derived DCs.

148 To investigate this, we utilized human monocyte-derived DCs (MoDCs) and primary endothelial cel

149 yed in gammadelta T-APCs compared with human monocyte-derived DCs (moDCs).

150 Immature monocyte-derived DC (iMDDC) failed to undergo phenotypic

151 ocytosis of recombinant ADAMTS13 by immature monocyte-derived DCs using flow cytometry and confocal m

152 HIV infection, we conditioned human immature monocyte-derived DCs (moDCs) with RA (RA-DCs), before pu

153 e the first to identify a subset of immature monocyte-derived DCs constitutively expressing IL-32 and

154 that DC-SIGN is highly expressed on immature monocyte-derived DCs, with at least 100,000 copies and o

155 The impaired monocyte-derived DC recruitment in DEP-exposed CCR2 knoc

156 irrespective of heat stress and infection in monocyte-derived DC and may function to positively regul

157 We quantified the expression of IL-23 in monocyte-derived DCs in MS patients and healthy donors a

158 chemokines and proinflammatory cytokines in monocyte-derived DCs (moDCs), with the notable exception

159 DC-SIGN is expressed in monocyte-derived DCs (MDDCs), macrophage subsets, activa

160 infection and during viral Tat expression in monocyte-derived DCs.

161 G2 signaling induces key LCH-cell markers in monocyte-derived DCs, suggesting a functional role of No

162 mbrane trafficking proteins was performed in monocyte-derived DCs.

163 -stimulated gene expression predominantly in monocyte-derived DCs.

164 show that inhibition of HIV-1 replication in monocyte-derived DCs (MDDCs) is associated with an incre

165 te to the inhibition of HIV-1 replication in monocyte-derived DCs through multiple mechanisms.

166 Aspergillus-infected monocyte-derived DCs and neutrophils recruit pDCs, which

167 Inflammatory monocyte-derived DCs and CD4(+) T cells were also reduce

168 imulated primary blood MDCs and inflammatory monocyte-derived DCs (MDDCs) with TLR ligands, resulting

169 profound metabolic regulator in inflammatory monocyte-derived DCs.

170 erentiation of CCR2-dependent monocytes into monocyte-derived DCs (Mo-DCs) in the lungs after F. tula

171 ion and a CD11c(hi)MHCII(int)CD11b(+)Ly6C(+) monocyte-derived DC population.

172 When human and rhesus macaque monocyte-derived DCs were exposed to recombinant ALVAC,

173 s reminiscent of that which occurs in mature monocyte-derived DCs and that it varies with the activat

174 we compared chemotactic responses of mature monocyte-derived DCs and maturation agent lipopolysaccha

175 strate that immature and CD40 ligand-matured monocyte-derived DC have characteristic phenotypic and f

176 ine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th

177 These data reveal a way in which migratory monocyte-derived DCs and other DCs, like lymph node resi

178 DCs derived from peripheral blood monocytes (monocyte-derived DC; Mo-DC).

179 tain increased numbers of CCR2(+) monocytes, monocyte-derived DC (moDC), and exudate macrophages (exM

180 ns cells (LCs), conventional DCs, monocytes, monocyte-derived DCs, macrophages, and plasmacytoid DCs

181 aracterize the responses of human monocytes, monocyte-derived DCs and blood DC subsets to 13 vaccines

182 either alter the capacity of myeloid DCs nor monocyte-derived DCs to induce CD4 T cell proliferation.

183 e T cell proliferation (equivalent to normal monocyte-derived DC).

184 mplex antigens, either cDC1 or cDC2, but not monocyte-derived DCs, could carry out cross-presentation

185 sduce CD34(+) progenitor-derived DCs but not monocyte-derived DCs.

186 he altered maturation and early apoptosis of monocyte-derived DC may represent another mechanism by w

187 in conditions supporting the development of monocyte-derived DC.

188 maturation and IL-6 and IL-10 production of monocyte-derived DC.

189 tained scattered cells in cytospin slides of monocyte-derived DC with long, thin, beaded membrane pro

190 ation events upstream of the accumulation of monocyte-derived DCs in lymph nodes (LNs).

191 s a major role in hMPV-induced activation of monocyte-derived DCs (moDCs), as downregulation of its e

192 zed by enhanced type 1 IFN and activation of monocyte-derived DCs but diminished cDC type 1 IFN respo

193 lating immunity, we compared the capacity of monocyte-derived DCs (moDCs) with that of CD34+ hematopo

194 The in vitro development of monocyte-derived DCs was almost completely blocked when

195 ct of CXCL4 on the phenotype and function of monocyte-derived DCs (moDCs).

196 While productive infection of monocyte-derived DCs activated antiviral and type I inte

197 -kappaB pathways in AC-induced inhibition of monocyte-derived DCs.

198 uced the rapid appearance of a population of monocyte-derived DCs in the draining lymph node, early r

199 some inflammatory cells are a population of monocyte-derived DCs.

200 Transcriptomes and proteomes of monocyte-derived DCs polarized toward DCs driving the di

201 flammation, CCR2 mediated the recruitment of monocyte-derived DCs to the perivascular region, and Fpr

202 Stimulation of monocyte-derived DCs with CD40LT enhanced the production

203 V and exhibit a phenotype similar to that of monocyte-derived DCs routinely used for in vitro studies

204 gated the role of Fpr2 in the trafficking of monocyte-derived DCs in allergic airway inflammation in

205 tributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can po

206 DC maturation, we developed a model based on monocyte-derived DC (moDC) and calibrated NETs isolated

207 fects of coinfection with HIV-1 and HSV-2 on monocyte-derived DCs (MDDC).

208 nregulate cell-surface expression of CCR1 on monocyte-derived DCs and diminish their calcium flux in

209 itive setting, alpha4 integrin deficiency on monocyte-derived DCs was fully compensated.

210 DC-SIGN is expressed on monocyte-derived DCs in culture, and importantly, it is

211 was investigated by analyzing its impact on monocyte-derived DCs.

212 tolerogenic and anti-inflammatory profile on monocyte-derived DCs (MoDCs) challenged by a proinflamma

213 Engagement of TLR3 or TLR4 on monocyte-derived DCs induces RGS16 and RGS20, markedly i

214 The abilities of primary BDCA1(+) or monocyte-derived DCs from HCV patients (HCV-DC) to stimu

215 rd monocyte-derived macrophages (mo-Macs) or monocyte-derived DCs (mo-DCs) and which transcription fa

216 ocesses, morphologically distinct from other monocyte-derived DC.

217 ver, the phenotype and function of patients' monocyte-derived DCs (MoDCs), which are commonly used fo

218 DCs are TNF-producing and IL-1beta-producing monocyte-derived DCs, including a population of inflamma

219 Moreover, tumor progression, monocyte-derived DC infiltration, and intratumoral angio

220 d DC and may function to positively regulate monocyte-derived DC, especially during critical periods

221 these results reveal that Dectin-2 regulates monocyte-derived DC function in the pulmonary microenvir

222 (M-CSF)-dependent, CD14(+)CD11b(+)DC-SIGN(+) monocyte-derived DCs.

223 Since monocyte-derived DCs possess only low-cell surface level

224 nduced by tubercle bacillus Ag 85-stimulated monocyte-derived DCs.

225 lls (DCs) in the immune response, we studied monocyte-derived DCs (moDCs) and plasmacytoid DCs (pDCs)

226 gene expression in heterogenous DC subsets, (monocyte-derived DCs [MDDCs], CD34(+) hematopoietic stem

227 IL-22-producing cells more efficiently than monocyte-derived DCs.

228 at CD1a-restricted antigen presentation than monocyte-derived DCs.

229 In this study, it is demonstrated that monocyte-derived DCs from patients with chronic HCV infe

230 ed lung DCs from C57BL/6 mice and found that monocyte-derived DCs (moDCs), including CD11b(hi)Ly-6C(l

231 Finally, it was found that monocyte-derived DCs acquired the ability to secrete int

232 These results indicate that monocyte-derived DCs will be easier to load by using pro

233 These data suggest that monocyte-derived DCs, recruited in a CCR2-dependent mann

234 When these monocyte-derived DCs exit skin to emigrate to LNs, they

235 have dramatically enhanced gene transfer to monocyte derived DC (MDDC) by retargeting adenoviral (Ad

236 However, in comparison to monocyte-derived DC (moDC), they respond to pathogen enc

237 fusion assay, we now show that HIV fusion to monocyte-derived DCs (MDDCs) both decreases and kinetica

238 Exposure of total monocyte-derived DCs (MDDCs) to S. aureus lysates as wel

239 5 vectors expressing SIV Gag Ag to transduce monocyte-derived DC from rhesus macaques, and then immun

240 We then transfected monocyte-derived DCs from healthy donors with antisense

241 capacity of stroma-conditioned media-treated monocyte-derived DCs and primary human gastric and intes

242 ession in H. ducreyi-infected and uninfected monocyte-derived DC.

243 ly published that CD37 is downregulated upon monocyte-derived DC activation, promotes migration of bo

244 n by human myeloid cells was confirmed using monocyte-derived DC and M1 macrophages.

245 transmission, and productive infection using monocyte-derived DCs (MDDCs), blood myeloid DCs, and B-c

246 d tissue CD1alpha+ DC as well as on in vitro monocyte-derived DC.

247 It bound to in vitro monocyte-derived DCs and to in vivo CD1c(+)CD1a(+) derma

248 presentation of the antigen days later when monocyte-derived DCs migrated to lymph nodes or in vitro

249 In other studies, when monocyte-derived DCs have been utilized to sensitize tot

250 d IL-12 and IL-10 at similar levels, whereas monocyte-derived DC produced comparable levels of IL-12,

251 responses within PBMCs or in coculture with monocyte-derived DCs.

252 observed interaction of human platelets with monocyte-derived DCs, but also that platelet activation

253 We also compared these with monocyte-derived DCs (MDDCs) and MUTZ3 Langerhans cells

254 The expression of Factor XIIIa(+) monocyte-derived DCs, CD4(+) and CD8(+) T cells, CD20(+)