ライフサイエンスコーパス: monospecific

1 y repertoire of the quasimonoclonal mouse is monospecific.

2 ly occurring IgG antibodies are bivalent and monospecific.

3 g) mice peripheral T cells were functionally monospecific.

4 Monospecific (177)Lu- and (111)In-labeled trastuzumab Fa

5 EG24-EGF or (111)In-DTPA-Fab-PEG24-EGF or to monospecific (177)Lu- or (111)In-labeled trastuzumab Fab

6 zation efficacy compared with the respective monospecific Ab subunits as well as a mixture of the two

7 butes to the development of lymphocytes with monospecific Ag receptors.

8 eutrophils) has prevented the development of monospecific agents against these therapeutic targets.

9 bsRICs were more effective than monospecific agents.

10 na, primarily occurring as multi-individual, monospecific aggregates of semi-articulated skulls and s

11 na, primarily occurring as multi-individual, monospecific aggregates of semi-articulated skulls and s

12 thane consumption either as single cells, in monospecific aggregates, or in multispecies consortia.

13 on with bacteria, they also were observed as monospecific aggregations and as single cells.

14 -1 archaeal group more frequently existed in monospecific aggregations or as single filaments, appare

15 ematosus (SLE) (group 1), 2) sera with known monospecific ANA reactivity (group 2), and 3) sera from

16 and HCV produced in cell culture compared to monospecific and cocktail controls.

17 arburg, Sudan, and Ebola viruses to generate monospecific and cross-reactive antibody responses again

18 We analyzed monospecific and cross-reactive recognition by diverse T

19 ntibody response in SHIV-infected monkeys is monospecific and directed against epitopes composed of t

20 ersatility of MVsim, we first show that both monospecific and multispecific multivalent ligand-recept

21 Using Western blots probed with two Msp2-monospecific and one Msp2-monoclonal antibodies, we dete

22 Monospecific AnkA antibodies reacted with proteins in HG

23 CD38, it immunoreacted with three different monospecific anti-CD38 antibodies on immunoblots, and it

24 anisms that hamper treatment of myeloma with monospecific anti-CD38 antibodies.

25 osomes from phenobarbital-treated males with monospecific anti-CYP2B monoclonal antibodies (Mab) inhi

26 Shear-loading of monospecific anti-fascin immunoglobulins, which block th

27 Immunohistochemistry employing a monospecific anti-FLIP antibody was performed on RA and

28 antibody against human NGAL as well as by a monospecific anti-human MMP-9 antibody.

29 Immunoprecipitation experiments using monospecific anti-IAP100 antibodies and a nonionic deter

30 he same 185-kD glomerular protein as did the monospecific anti-PLA(2)R antibody.

31 One monospecific anti-single-stranded (ss) DNA (11F8) induce

32 Using monospecific anti-SpKAP115 antibodies we have accomplish

33 Immunoblot analysis using monospecific anti-VlsE revealed the presence of prominen

34 cacy against Streptococcus pneumoniae, human monospecific antibodies (MAbs) to serotype 3 pneumococca

35 We used fluorescent microscopy, monospecific antibodies against complement components, f

36 roblotting and immunochemical staining using monospecific antibodies against SAP-2, two or three majo

37 en hamsters demonstrates the efficacy of the monospecific antibodies against the original Wuhan strai

38 Double indirect immunofluorescence using monospecific antibodies demonstrated that a subset of CE

39 Monospecific antibodies directed against the four distin

40 ere, TACC3 and cKAP5/chTOG localization with monospecific antibodies is investigated in eGFP-centrin-

41 Anti-recombinant ePAD monospecific antibodies localized the molecule to the cy

42 Monospecific antibodies raised against four synthetic pe

43 on and immunoelectron microscopy using these monospecific antibodies revealed that PfNT1 localizes pr

44 During the past decade, monospecific antibodies targeting cell-surface receptors

45 therapeutic efficacy, but administration of monospecific antibodies targeting individual inhibitory

46 e immunologic evaluation with monoclonal and monospecific antibodies to be identical to or an isoform

47 o acid sequencing and Western analysis using monospecific antibodies to each toxin demonstrated that

48 microinjection studies were performed using monospecific antibodies to myosin IIA and IIB isotypes.

49 Complete sequence coverage of monospecific antibodies was previously achieved using im

50 Monospecific antibodies were generated that recognize th

51 ycan plays in the developing nervous system, monospecific antibodies were prepared and used to locali

52 Monospecific antibodies were used to identify ACE, macro

53 By using these monospecific antibodies, a 1.096-kb human cDNA that enco

54 hepatoma cells by immunohistochemistry with monospecific antibodies, confocal microscopy, and matrix

55 laminin alpha, beta, and gamma chains using monospecific antibodies.

56 unoprecipitation of the PB1-PB2 complex with monospecific antibodies.

57 by coimmunoprecipitation (co-IP) assay using monospecific antibodies.

58 n) were identified on adjacent sections with monospecific antibodies.

59 ined by immunohistochemistry with the use of monospecific antibodies.

60 ion of NOS2 in patients with AD, using three monospecific antibodies: a previously described polyclon

61 ntibodies are asymmetrical compared to their monospecific antibody counterparts, resulting in a decre

62 Monospecific antibody fragments produced in bacteria lac

63 Using a monospecific antibody raised against native Xp54, its pr

64 mmunoscreening of an expression library with monospecific antibody resulted in the isolation of a cDN

65 tates did not contain RNA polymerase I, as a monospecific antibody to the 194-kDa subunit of RNA poly

66 a bispecific antibody and Met oxidation in a monospecific antibody, both occurring within the complem

67 An Fab fragment of a monospecific antibody, which binds to residues 39 to 55

68 ty and location of the target antigen with a monospecific antibody.

69 lic fragments of aggrecan were detected with monospecific antipeptide antibodies.

70 The topology of Fpn was determined using monospecific antisera against its different epitopes, in

71 Monoclonal and monospecific antisera against MSPs 1 through 5, initiall

72 Antibody supershift assays using monospecific antisera against NF-kappaB subunits (p50 an

73 eu121 --> Lys126 and Phe198 --> Lys220), and monospecific antisera against p45 and RHL-1 cross-reacte

74 Immunofluorescence methods using monospecific antisera and distinct fluorophores identifi

75 114 phase partitioning, and used to generate monospecific antisera in rats.

76 By using monospecific antisera in Western blot and flow cytometry

77 surfaces by immunofluorescence assays using monospecific antisera raised to the recombinant protein

78 Surface localization of OmcB was shown using monospecific antisera specific to the 20-mer OmcB peptid

79 Here we have raised for the first time monospecific antisera to CENP-A [3], a 17 kD centromere-

80 Immunofluorescence staining with monospecific antisera to purified PorB revealed antigen

81 igenic determinants were surface accessible, monospecific antisera were raised to the PorB peptides a

82 encing were confirmed by neutralization with monospecific antisera.

83 taining both proteins were precipitated with monospecific antisera.

84 purified and used to raise rabbit polyclonal monospecific antisera.

85 ction were identified by immunoblotting with monospecific antiserum and convalescent rat serum in add

86 ved only in yolk sac, kidney, and ileum with monospecific antiserum for p400.

87 e pretreated intranasally with RSVIg or with monospecific antiserum obtained from animals previously

88 ts, sera from chronically infected mice, and monospecific antiserum to the antigenic variation protei

89 purified was used to raise rabbit polyclonal monospecific antiserum.

90 Isotopic analyses suggest that monospecific archaeal cells and cell aggregates were act

91 of the expected size on immunoblots and were monospecific based on peptide competition studies.

92 can limit the efficacy of receptor-targeted monospecific-based therapies.

93 CAR-T exhibits improved efficacy compared to monospecific BCMA-CAR-T-cell therapy.

94 and Pro/Pre B cells that do not express KIT, monospecific BCR-ABL inhibition was quantitatively as ef

95 nov., based primarily on monospecific bedding plane assemblages from the Lower-Mi

96 tantial and perennial colonization featuring monospecific biofilms at the surface of the aggregates.

97 s for direct in vivo delivery of DNA-encoded monospecific/bispecific antibodies offer novel tumor-tar

98 repertoire of this quasi-monoclonal mouse is monospecific, but somatic hypermutation and secondary re

99 ed to recombinant BmpA (rBmpA) were rendered monospecific by absorption with rBmpB.

100 ells more effectively eliminated tumors than monospecific CAR T cells in vivo.

101 ch allows tumor cells to evade conventional, monospecific CAR T cells.

102 ression and improving function compared with monospecific CAR T cells.

103 loma cell lines, and was more effective than monospecific CD20-targeted MAb-IFNalpha or a mixture com

104 In both models, these monospecific CD4 T cells influenced the course of infect

105 this experimental tool, which can produce a monospecific CD4 T-cell response.

106 -specific proliferation in vitro relative to monospecific CD4+ T cells, which was consistent with low

107 or PD-L1-deficient mice induced K(b)/A12-21-monospecific CD8(+) T cells and autoimmune diabetes.

108 We found that monospecific CD8+ T cells introduced into tolerant anima

109 produced IFN-gamma, but differed from EBNA1-monospecific cells in their capability to produce interl

110 inhibitors to overcome resistance to current monospecific checkpoint antibodies or their combinations

111 tissues by immunohistochemistry with both a monospecific chicken anti-Neu5Gc antibody and with affin

112 ific antibody per ml from affinity-isolated, monospecific chicken antibody preparations and to measur

113 antibody specifically from IgY fractions of monospecific chicken antibody preparations.

114 l basis for recognition of SSEA-4 by a novel monospecific chimeric antibody (ch28/11).

115 80% more species of twig-nesting ants than a monospecific collection of twigs.

116 sandy sea bed and lived in dense, typically monospecific concentrations.

117 When compared to monospecific constructs, the biparatopic antibody demons

118 Immunohistochemical staining with a monospecific COX-2 antibody confirmed that increases in

119 ive in preventing T1D induced by transfer of monospecific diabetogenic CD4 and CD8 transgenic T cells

120 Renin is a monospecific enzyme that catalyzes the rate-limiting ste

121 levels of expansion than T cells recognizing monospecific epitopes because of more frequent stimulati

122 rent Fabs together, we produced a variety of monospecific F(ab')(2)-like molecules with activities sp

123 6 h postinjection; n = 4) compared with each monospecific Fab tracer.

124 The monospecific family Mysteriomorphidae was recently descr

125 ro with an anti-CD4 mAb allowed T cells from monospecific female TCR-transgenic mice against the male

126 The monospecific fern genus Cystodium (Cystodiaceae; Polypod

127 ted with an antibody documented herein to be monospecific for human NOS2.

128 y positive spots from probes predicted to be monospecific for influenza virus species, subtype, host

129 t was then affinity purified and shown to be monospecific for MAP4.

130 Two different antibodies monospecific for myeloperoxidase identified a 60-kd prot

131 finities for rocuronium with families either monospecific for rocuronium or cross-reactive only for c

132 e strains, A1(M).RAG1(-/-) and Marilyn, each monospecific for the male antigen Dby.

133 gonia, the ECM tree Nothofagus pumilio forms monospecific forests along mountain slopes without confo

134 n species richness and relative abundance in monospecific forests.

135 -glucose dehydrogenase, corresponding to the monospecific form, ubiquitous amongst plants and animals

136 We show here, however, that anti-H-Y monospecific, H-2(b-restricted MataHari CD8(+) T cells r

137 selective immunization to produce a robust, monospecific helper T-cell response in mice using a modu

138 Three such constructs, 20-20, a monospecific HexAb comprising 6 Fabs of veltuzumab (huma

139 Using immunoperoxidase microscopy with a new monospecific human iNOS antibody (NO-53), the cellular d

140 This represented an essentially monospecific IgG population.

141 The Cf-2 protein, originally identified as a monospecific immune receptor for the leaf mold fungus Cl

142 loride creating an aqueous aluminum solution monospecific in MAl12(7/8+).

143 Site(-1) was found to be monospecific in the Erbin PDZ domain (accepts tryptophan

144 Using unique, monospecific inhibitors against MASP-1 and MASP-2, we co

145 Lineatriton, long thought to be a unique monospecific lineage, is polyphyletic.

146 isms that orchestrate the differentiation of monospecific lymphocytes while suppressing oncogenic Ag

147 t required for measurable insulin binding by monospecific mAb from adult mice.

148 BM (CD20(+)/HLA-DR(+) myeloma) compared with monospecific MAb-IFNalpha, which targets only HLA-DR or

149 We evolved a pair of monospecific MASP inhibitors.

150 In assays involving alternating stripes of monospecific matrices, human control GCs exhibited no pr

151 Importantly, monospecific MSA-1 and RAP-1 antisera each inhibited spo

152 Monospecific neuraminidase (NA) subtype probes were insu

153 Notably, children with preexisting monospecific neutralizing antibody responses were more l

154 g PD-1(+) CLL cells with depleting anti-PD-1 monospecific or bispecific antibodies should be explored

155 Multivalent antibodies, either monospecific or bispecific, may improve the efficacy of

156 Using coimmunoprecipitation with monospecific or monoclonal antibodies, we observed that

157 itute a group of T cells that express mainly monospecific or oligoclonal T cell receptors (TCRs).

158 In contrast, human Tie-2-monospecific pAd-1S05 intrabody did not affect the growt

159 The antigen-binding fragment (Fab) of a monospecific peptide 1 (P1) antibody, which was raised a

160 accumulation within the biomass compared to monospecific planting.

161 otype neutralization could be generated from monospecific plasma.

162 Monospecific polyclonal anti-p45 IgG detected p45 in cru

163 We have produced monospecific polyclonal antibodies against TPH1 and TPH2

164 ic compounds with high affinity for LRAT and monospecific polyclonal antibodies raised in rabbits aga

165 Monospecific polyclonal antibodies to the 100-kDa protei

166 We have made monospecific polyclonal antibodies to the protein and co

167 s by analyzing the consequences of injecting monospecific polyclonal antibodies to xNup98 into X. lae

168 In addition, monospecific polyclonal antibodies were used to demonstr

169 cted in wild-type-infected cells with rabbit monospecific polyclonal antibody directed against a fusi

170 Using a monospecific polyclonal antibody raised against SirR to

171 A monospecific polyclonal antiserum to an Escherichia coli

172 Using monospecific polyclonal peptide antisera that recognize

173 he other, they are present as an essentially monospecific population (VH3H9/Vkappa8).

174 ls, as the induction of CD25 expression on a monospecific population of T cells derived from TCR tran

175 n the current study, mAb BM8 was used as the monospecific probe to characterize its antigen (AgBM8) i

176 Monospecific rabbit antibodies to FP-1 recognize in cult

177 sion in rat brain and spinal cord by using a monospecific rabbit antiserum produced against bacterial

178 They all reacted with monospecific rabbit antiserum to the purified S-layer of

179 blocked by soluble LIMPII fusion protein, by monospecific rabbit IgG directed against the LIMPII pept

180 Monospecific rabbit polyclonal antibody produced to a gl

181 re, the thawed gel is sandwiched between two monospecific reagent DET gels, leading to magenta and bl

182 d from the brain of an SSPE patient, or on a monospecific recombinant Fab identified from SSPE brain.

183 However, these assays are mostly monospecific, requiring separate amplifications for each

184 giogenic activity, whereas the effect of the monospecific scFv intrabodies was weaker.

185 formation in Matrigel plugs in vivo, whereas monospecific scVEGF mutants that bind VEGFR2 or alpha(v)

186 Compared to monospecific scVEGF mutants that bind VEGFR2 or alpha(v)

187 Cross-reactivity with monospecific sera and monoclonal antibodies to p40 was f

188 eened a panel of murine monoclonal and human monospecific sera reactive with known autoantigens for t

189 iofilm composition (natural multispecies vs. monospecific species) may influence the outcomes.

190 robabilities more than sevenfold higher than monospecific stands (~0.6% year-1 in monospecific stands

191 ly equivalent positions along creek banks in monospecific stands of Spartina alterniflora (smooth cor

192 unced but still significant (~1.1% year-1 in monospecific stands to 1.8% year-1 in the most species-r

193 er than monospecific stands (~0.6% year-1 in monospecific stands to 4.0% year-1 in the most species-r

194 roductivity, stress, and mortality in mature monospecific stands with soil, species, and climate samp

195 The marine bacterium Vibrio fischeri is the monospecific symbiont of the Hawaiian bobtail squid, Eup

196 Transfer of polyclonal monospecific syngeneic mouse anti-Neu5Gc serum also enha

197 epresented the same Th1 phenotype as that of monospecific T cells recognizing MBP(93-105).

198 ired tolerance was dominant, such that naive monospecific T cells were not able to override tolerance

199 This subset can be derived from mature monospecific T cells without "tutoring" by other T cells

200 he same antigen in the same cancer cells via monospecific T cells, which have similar pMHC and pMHC-T

201 n on adoptive transfer compared with that of monospecific T-cell clones.

202 Using mutant and transgenic animals with a monospecific TCR, we discovered increased numbers of MP

203 lso able to induce tolerance in vivo in such monospecific TCR-transgenic mice, and this too was depen

204 Analysis of the effect of the monospecific TCR-transgenic T cells on the host response

205 o circumvent the limitations of conventional monospecific therapies and achieve enhanced therapeutic

206 s with capabilities that are inaccessible to monospecific therapies.

207 pecies richness and trait dissimilarity from monospecific to high-diversity neighbourhoods enhanced i

208 s showed that the monobodies are essentially monospecific to SHP2.

209 network of multispecific, oligospecific, and monospecific transporters and enzymes in regulating smal

210 obody compound or combination treatment over monospecific treatments in both in vitro and in vivo mod

211 ring persistent infection, in the setting of monospecific VP1 Ab, was required for outgrowth of VP1 A

212 s of burned area proportion per forest type (monospecific vs. polyspecific), we detected differential