ライフサイエンスコーパス: monovalent

1 ined from human subjects vaccinated with the monovalent 2009 H1N1 influenza vaccine.

2 inactivated subunit vaccine (ISV) targeting monovalent 2009 pandemic influenza A(H1N1) virus or live

3 and biopanning, we identified two functional monovalent Abs (nanobodies) targeting ChemR23.

4 A maternal monovalent acellular pertussis (aP) vaccine, in developm

5 he divalent GLP-1 analogues were superior to monovalent analogues with respect to control of glucose

6 ligand, have better tumor uptake than their monovalent analogues.

7 that this approach enables the generation of monovalent and bivalent antibodies with nanomolar affini

8 Specifically, a series of monovalent and bivalent bispecific IgGs composed of the

9 this paper, we study cholesteric shells with monovalent and bivalent defect configurations.

10 eed oleosomes at pH 7 and at the presence of monovalent and divalent cations (Na(+), K(+), Mg(2+)(,)

11 on of -0.96 +/- 0.03 and -0.52 +/- 0.01 with monovalent and divalent cations, respectively, and these

12 s are typically performed in the presence of monovalent and divalent cations.

13 ajority of clinically used opioid drugs, are monovalent and divalent cations.

14 Changes in monovalent and divalent ion concentrations drive an abru

15 eement with experiments over a wide range of monovalent and divalent ion concentrations.

16 everal RNA molecules in a mixture containing monovalent and divalent ions.

17 in the presence of defined concentrations of monovalent and divalent ions.

18 We next synthesized divalent M2pep with monovalent and divalent KLA ([M2pep]2-[KLA] and [M2pep]2

19 5 A as well as modest (30-40%) retention of monovalent and divalent salts.

20 e in sharp contrast to interactions of ions (monovalent and divalent) with rigid charged rods, in whi

21 The functional properties of monovalent and heterobivalent ligands were characterized

22 monovalent (single binding site) Pproxy and monovalent and multivalent (multiple equivalent and inde

23 methods are currently available to study how monovalent and multivalent GAG.protein bonds respond to

24 te tertiary fold of the RNA domain, with one monovalent and several divalent ions located in specific

25 ersus intramuscular injection in rats, using monovalent and trivalent formulations of IPV.

26 Since glutamate is the major monovalent anion in E. coli, these results suggest that

27 manner for POPA and PIP2 lipids; and 6) the monovalent anion type has little influence on the lipid

28 te transporters (FNTs) selectively transport monovalent anions and are found in prokaryotes and lower

29 bsolute salinity concentrations by detecting monovalent anions and cations.

30 nels, which mediate the influx and efflux of monovalent anions in response to the levels of intracell

31 dated using a clinically available blocking, monovalent anti-CD28 antibody (FR104) whose effects in a

32 Here, we introduce a strictly monovalent anti-TCRbeta H57 Fab' ligand that, when coupl

33 bodies exhibit agonistic properties, whereas monovalent antibodies lack potency and the capacity to d

34 es was both sufficient and necessary whereas monovalent antibodies were poor inhibitors.

35 devised an evolutionary strategy to isolate monovalent antibody fragments that bridge together two d

36 nal modeling, we found that the potency of a monovalent antibody targeting Met could be dramatically

37 coded unmutated common ancestors (UCAs), and monovalent antigen-binding fragments (Fabs) to investiga

38 o produce (89)Zr-radiolabeled onartuzumab (a monovalent, antihuman c-MET antibody), starting directly

39 mune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange.

40 2009 and 1 October 2011 to mothers receiving monovalent AS03-adjuvanted H1N1 influenza vaccine (Pande

41 requirement for stable immobilization, while monovalent attachment is reversible and, in the case of

42 have predicted and measured varied from the monovalent binding interaction by several orders of magn

43 nly found throughout biology to enhance weak monovalent binding such as between glycoligands and prot

44 demonstrate two distinct modes of binding, a monovalent binding to shorter saccharides and a bivalent

45 Affinity-reduced monovalent bispecific variants, but not their bivalent b

46 of Capsid protein containing VLPs either as monovalent, bivalent or tetravalent formulation resulted

47 Coadministration of monovalent, bivalent, or trivalent OPV seems to lower RV

48 Thus, monovalent blocking of FcgammaR function demonstrates a

49 Monovalent blocking of FcgammaR function dramatically in

50 An electron-rich monovalent boron compound is used as a Lewis base to pre

51 (2)) bond scission in alkenes by inserting a monovalent carbon unit between both sp(2)-hybridized car

52 times lower than those required for similar monovalent catalysts and displays unique kinetic paramet

53 etal halide perovskites ABX(3), where A is a monovalent cation (e.g., methylammonium (MA(+)), Cs(+)),

54 Ddl is activated by the monovalent cation (MVC) K(+), but despite its clinical r

55 d Mg(2+)) were more than 31-fold of that for monovalent cation (Na(+) and K(+)).

56 that PFL-AE binds a catalytically essential monovalent cation at its active site, yet another parall

57 PM4, which encodes TRPM4, a Ca(2+)-activated monovalent cation channel, as a cause of an autosomal do

58 t that shear stress indirectly activates the monovalent cation current carried by transient receptor

59 e Ppz1 (ScPpz1) is involved in regulation of monovalent cation homeostasis.

60 ounds tested, salinomycin and monensin, both monovalent cation ionophores, displayed a potent and sel

61 Potassium (K(+)) is a key monovalent cation necessary for multiple aspects of cell

62 This monovalent cation site controls enzyme activity: (i) PFL

63 e NaGaS(2) composition, which contains Na, a monovalent cation slightly larger in size than Li, found

64 se at a range of temperatures, buffer pH and monovalent cation strength.

65 (14C)-citrate anion, as well as the organic monovalent cation, ethidium, but not its divalent analog

66 d perovskite solar-cell absorbers APbX3 (A = monovalent cation; X = Br or I).

67 n member 4 (TRPM4) channels are nonselective monovalent cationic channels found in human atria and co

68 e of divalent cations (Ca(2+) and Ba(2+)) as monovalent cations (K(+)), but a viroporin defective mut

69 or Ca(2+) over Na(+), but nonselective among monovalent cations (Li(+), Na(+), and K(+)).

70 strongly depend on the cation employed, with monovalent cations (Na(+) and K(+)) leading to the highe

71 Kd approximately 1.6 mM) compared with other monovalent cations and relevant, considering lithium dos

72 has high permeability to calcium relative to monovalent cations and shows inward rectification.

73 lex structures made of stacked guanines with monovalent cations bound at a central cavity.

74 Ribozyme activity depends on Mg(+2) and monovalent cations but is resistant to protease treatmen

75 conducted primarily ( approximately 80%) by monovalent cations but not Ca(2+) .

76 al of divalent cations (i.e., hardness) over monovalent cations can simply be achieved using membrane

77 ity: (i) PFL-AE in the absence of any simple monovalent cations has little-no activity; and (ii) amon

78 h a closed transmembrane pore, with resolved monovalent cations intracellular to the hydrophobic gate

79 proximal promoter (kit2) in the presence of monovalent cations K+ and Na+.

80 t metals such as Ca(2+), Mg(2+), and Zn(2+), monovalent cations often function as efficient and selec

81 ike many other TRP channels, is permeable to monovalent cations only.

82 The presence of monovalent cations resulted in aggregation and minor coa

83 channels in TAL: a cldn10b-based channel for monovalent cations such as Na(+) and a spatially distinc

84 ical standpoint is possible, particularly by monovalent cations such as NH4(+), or K(+).

85 ference interaction site (3D-RISM) model for monovalent cations surrounding DNA and RNA helices, and

86 h selectivity ratios of over 100 and conduct monovalent cations up to 5 times more rapidly than dival

87 ivalent cations are preferentially lost over monovalent cations upon A.C protonation, providing exper

88 of cooperative association dependent on GTP, monovalent cations, and Mg(2+).

89 ents, we show that this compound binds large monovalent cations, such as Cs(+) and Tl(+), with a bind

90 interaction model with explicit divalent and monovalent cations, that ion condensation is highly spec

91 lent cations preferentially bind to DNA over monovalent cations, which attenuates non-specific intera

92 p to approximately 4-5 times compared to the monovalent cations.

93 ized by Hoogsten pairing and centrally bound monovalent cations.

94 ionally wide filter but is only permeable to monovalent cations; filter residue Gln973 is essential i

95 curred by substitution of divalent S(2-) for monovalent Cl(-) play a major role in enhancing Li(+) -i

96 to a second distinct site on LRP1 to form a monovalent complex.

97 on, with affinities greatly exceeding either monovalent component.

98 ypes that were specific to each of the three monovalent components of the trivalent influenza vaccine

99 ltivalent binding into actions of individual monovalent components, they also demonstrated a strong a

100 data show that PAM has superiority over its monovalent counterpart in powering NKs to bind to cancer

101 functional profile that was unique from its monovalent counterpart providing evidence of the discret

102 creased affinity and specificity relative to monovalent counterparts, but these emergent biochemical

103 Relative to their monovalent counterparts, where the sigma-hole is located

104 ng potency by 3- to 5-fold compared to their monovalent counterparts.

105 Moreover, monovalent CTxB does not stabilize membrane domains, unl

106 The best monovalent decoy, CTC-445.2, bound with low nanomolar af

107 sed to primary DENV4 natural infections or a monovalent DENV4 vaccine were analyzed.

108 monovalent, divalent) and pH.

109 tions revealed significant differences among monovalent, divalent, and trivalent cation distributions

110 By screening an array of monovalent, divalent, and trivalent metal ions, we demon

111 A systematic comparison of transport of monovalent electrolytes [potassium chloride (KCl), sodiu

112 alf-life and absorption time compared to its monovalent equivalent.

113 se 3 clinical trials showed that inactivated monovalent EV-A71 vaccines manufactured in China were hi

114 Moreover, monovalent Fab fragments generated from the purified IgG

115 In the presence of heparin, the monovalent Fab shows essentially no inhibition, whereas

116 ovalent pMHC and unlike bivalent antibodies, monovalent Fab'-DNA triggers TCRs only when physically c

117 Mature mAbs, UCA mAbs, and mature monovalent Fabs bound to MuSK and demonstrated pathogeni

118 glycans over FimH on the cell surface favors monovalent FimH binding.

119 Serial passage of the monovalent FluMist 2009 H1N1 pandemic vaccine at increas

120 neered MM-131, a bispecific antibody that is monovalent for both Met and epithelial cell adhesion mol

121 iety, we further demonstrate that 1B1 in its monovalent form cannot block TCR-mediated NKT cell activ

122 Here, we introduce a monovalent form of Strep-Tactin that harbours a unique b

123 Early studies showed that a monovalent formalin-inactivated HRV vaccine can be prote

124 Botswana introduced monovalent G1P rotavirus vaccine (RV1) in July 2012, pro

125 In a monovalent G1P[8] rotavirus vaccine (RotarixTM) trial in

126 med active diarrhea surveillance to evaluate monovalent G1P[8] rotavirus vaccine (RV1) efficacy and u

127 nited States, we analyzed the association of monovalent H1N1 influenza vaccine (MIV) during pregnancy

128 sed the immunogenicity and safety of a novel monovalent high-dose inactivated poliovirus type 2 vacci

129 , we generated a fusion protein comprising a monovalent human FcgammaRIIIA-specific antibody linked i

130 rom Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8,

131 A monovalent human rotavirus vaccine (RV1) was introduced

132 >=11), from a phase 3 VE trial of Rotavac, a monovalent human-bovine (116E) rotavirus vaccine, carrie

133 accumulation of somatic mutations such that monovalent IgG4 Fab-arm-exchanged autoantibodies reach a

134 lpha-coated nanoparticles in comparison with monovalent IL-15:IL-15Ralpha.

135 tive antibody response in 75 recipients of a monovalent inactivated A/Shanghai/02/2013 H7N9 vaccine.

136 Vaccination in pregnancy with a monovalent inactivated AS03-adjuvanted split virion infl

137 0.22-6.63) per million doses for inactivated monovalent influenza vaccine (2 cases, 1,090,279 doses g

138 I trial using the Vaxxas HD-MAP to deliver a monovalent influenza vaccine that was to the best of our

139 The small group sizes and use of a monovalent influenza vaccine were limitations of the stu

140 ions of multivalency in order to unravel how monovalent interaction strength, scaffold flexibility, d

141 that stabilize the initial weak (micromolar) monovalent interaction.

142 are determined by several factors including monovalent ion composition and the precise sequence and

143 he substrate secondary structure or solution monovalent ion composition.

144 Slightly acidic pH and increased monovalent ion concentrations favor filament-assembly, -

145 on studies have supported the idea that this monovalent ion reduces agonist binding by stabilizing th

146 imescales are remarkably slow for individual monovalent ions and could have important implications fo

147 and seawater, both of which contain not only monovalent ions but also divalent ions.

148 ive excellent agreement with experiments for monovalent ions but underestimate Mg(2+)-DNA and Mg(2+)-

149 including Ca(2+), inhibit the permeation of monovalent ions by directly blocking the TRPP2 channel p

150 cations are known to be more efficient than monovalent ions in driving them to a compact state, alth

151 Our analysis shows that solvated monovalent ions permeate through the selectivity filter

152 oncentration difference between divalent and monovalent ions used in experiments, we develop a theory

153 ioning step to exchange divalent cations for monovalent ions, 0.2% carboxymethyl cellulose (CMC) 700

154 ledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global

155 keeping the implicit screening effect due to monovalent ions.

156 exhibit regulated permeability of water and monovalent ions.

157 d (N-N: 1.111(6) A) that bridges between two monovalent (iPr2) TpCu fragments.

158 critical to gain access to this 14-electron, monovalent Ir intermediate.

159 heptarepeats (starPEG-(KA7)(4))-but not its monovalent KA7-subunits-show advanced, biologically rele

160 increased by up to 1500-fold compared to the monovalent ligand, while maintaining the selectivity for

161 ng the negative cooperativity of binding of "monovalent" ligand tafamidis.

162 ser' family, is notably more potent than the monovalent ligands and we show here that this apparently

163 While the synthesized monovalent ligands retained the 5-HT(2A) antagonist and

164 nt capturing agents, released by competitive monovalent ligands, and then separated by filtration.

165 protein receptor have only low affinity for monovalent ligands.

166 hat define DNA-nanoparticles and compared to monovalent linker systems.

167 tion with minimal systemic exposure, whereas monovalent lipid-conjugated siRNAs were quickly released

168 In contrast to monovalent lithium or sodium ions, the reversible insert

169 0-fold lower concentration than required for monovalent M2pep activity.

170 acrophage-selective toxicity not observed in monovalent M2pep treatment.

171 different activation profiles than natural, monovalent, membrane-associated pMHC.

172 The phase II study GO27819 investigated the monovalent MET inhibitor onartuzumab plus bevacizumab (O

173 Ni(2+), Cu(2+), Zn(2+), and Cd(2+), but not monovalent metal ions, Cr(3+), Mg(2+), Y(3+), Sr(2+) or

174 Unlike conventional Fabs, which are monovalent monomers, Fab HC84.26.5D assembles into a biv

175 ii) conjugation with DNA and purification of monovalent MPNs, (iii) modular targeting of MPNs to cell

176 We sought to determine whether use of monovalent (mv) anti-FcepsilonRIalpha mAbs increases des

177 y evaluating the free energies for replacing monovalent Na(+) with H3O(+) in various model selectivit

178 ding aggregation kinetics in the presence of monovalent (Na(+)) and divalent cations (Ca(2+)) show th

179 -exchange metadynamics) to study and compare monovalent (Na(+), K(+)) ion permeation in the open-acti

180 aggregation under varying concentrations of monovalent (NaCl) and divalent (CaCl(2)) electrolytes.

181 avid binding by fusing multiple (different) monovalent Nanobody building blocks via linker sequences

182 ultivalent ureidopyrimidinone monomers and a monovalent naphthyridine molecule which acts as an end-c

183 ty of the bivalent configuration against the monovalent one is controlled by c = h/p, where h is the

184 to the substitution of divalent cations with monovalent ones, asphaltene deposition is repelled and t

185 lso model the trade-offs of use vs nonuse of monovalent OPV (mOPV) for outbreak response considering

186 The interference caused by bivalent and monovalent OPV formulations, which will be increasingly

187 adesh, were randomized to receive 3 doses of monovalent OPV type 1 or bivalent OPV types 1 and 3 at e

188 -specific IgA were measured in stool after a monovalent OPV type 2 challenge at 18 weeks of age.

189 omly assigned to receive one or two doses of monovalent OPV2 (n=50 in each group).

190 ion rate 28 days after one dose was 100% for monovalent OPV2 and both novel OPV2 candidates.

191 day 28 after the first vaccine dose) between monovalent OPV2 and the two novel OPV2 candidates.

192 Outbreak response campaigns with monovalent OPV2 are the only available method to induce

193 st was a phase 4 historical control study of monovalent OPV2 in Antwerp, done before global withdrawa

194 y of novel OPV2 day 28 seroprotection versus monovalent OPV2 in infants (non-inferiority margin 10%).

195 as safe, well tolerated, and immunogenic as monovalent OPV2 in previously OPV-vaccinated and IPV-vac

196 Yet our analysis shows that using monovalent OPV2 is generating more paralytic VDPV2 outbr

197 OPV2-c1 and high-dose novel OPV2-c2 despite monovalent OPV2 recipients having higher baseline immuni

198 OPV-vaccinated participants, 62 (62%) of 100 monovalent OPV2 recipients, 71 (71%) of 100 recipients o

199 valent Sabin OPV2 before global cessation of monovalent OPV2 use, and a phase 2 study with low and hi

200 100% of novel OPV2 vaccinees and 97 (97%) of monovalent OPV2 vaccinees were seropositive.

201 ted solicited systemic adverse events, four (monovalent OPV2), three (novel OPV2-c1), and two (novel

202 8]) of 97 were seroprotected after receiving monovalent OPV2, 134 (94% [88-97]) of 143 after high-dos

203 e genetically stable than the licensed Sabin monovalent OPV2, have been developed to respond to ongoi

204 assigned to either one dose or two doses of monovalent OPV2.

205 2) and OPV seroconversion was increased with monovalent or bivalent OPV compared with trivalent OPV (

206 ontrolled study, adults were challenged with monovalent oral poliovirus type 1 vaccine (mOPV1) and su

207 hromycin on the immunogenicity of serotype-3 monovalent oral poliovirus vaccine given to healthy infa

208 nce daily for 3 days, followed by serotype-3 monovalent oral poliovirus vaccine on day 14.

209 e performed a randomized controlled trial of monovalent oral rotavirus vaccine (RV1).

210 accine-derived polioviruses, we tested novel monovalent oral type-2 poliovirus (OPV2) vaccine candida

211 FR104 is a monovalent pegylated Fab' Ab, antagonist of CD28, under

212 fold higher potency compared to those of the monovalent peptides for the human Na(V)1.4 channel.

213 A monovalent pH1N1 vaccine was separately produced in addi

214 Importantly, like monovalent pMHC and unlike bivalent antibodies, monovale

215 Here, we used a monovalent probe, the silver ion, that, similarly to div

216 quinidine through a glycine linker, making a monovalent quinidine-polymer conjugate, which was then e

217 orrelation forces play a central role in the monovalent Rb(+) distribution and a combination of ion-c

218 assess the safety and immunogenicity of the monovalent, recombinant, chimpanzee adenovirus type-3 ve

219 red with dodecaglycosylated fullerenes and a monovalent reference.

220 and transcription factor-binding sites than monovalent regions.

221 rus vaccine (OPV) is known to interfere with monovalent rotavirus vaccine (RV1) immunogenicity.

222 Kenya introduced monovalent rotavirus vaccine (RV1) in July 2014.

223 among the first African nations to introduce monovalent rotavirus vaccine (RV1) into its childhood im

224 ne's Phase II and III clinical trials of the monovalent rotavirus vaccine (RV1), Rotarix, were analyz

225 We sought to determine monovalent rotavirus vaccine cost-effectiveness in Malaw

226 We evaluated monovalent rotavirus vaccine effectiveness (VE) under co

227 Monovalent rotavirus vaccine is effective in preventing

228 A monovalent rotavirus vaccine remains effective against a

229 Togo introduced monovalent rotavirus vaccine starting 19 June 2014.

230 In Bolivia, monovalent rotavirus vaccine was introduced in 2008 and

231 The monovalent rotavirus vaccine was introduced in Tanzania

232 Monovalent rotavirus vaccine was introduced in the routi

233 Monovalent rotavirus vaccine, Rotarix (GlaxoSmithKline),

234 ntirotavirus antibodies on immunogenicity of monovalent RV vaccine (RV1).

235 ainst rotavirus in Guatemala, where both the monovalent (RV1; 2-dose series) and pentavalent (RV5; 3-

236 e seek to determine the crystal structure of monovalent SA at 1.7-A resolution.

237 We found that a monovalent SA receptor binds to N2 with a significantly

238 protein of the influenza A virus than to the monovalent SA receptor.

239 The structural information of monovalent SA will be valuable for its applications acro

240 A SA variant, monovalent SA, was developed with a single and high affi

241 the two novel OPV candidates compared with a monovalent Sabin OPV in children and infants.

242 eks) in Panama: a control phase 4 study with monovalent Sabin OPV2 before global cessation of monoval

243 High concentrations of monovalent salt can induce the solubilization or crystal

244 K over a range of mechanical forces (fs) and monovalent salt concentrations (Cs).

245 ime-resolved dynamic light scattering at low monovalent salt concentrations and at three pH levels, i

246 ations in the electrolyte, NPs pairs at high monovalent salt concentrations interact via remarkably s

247 However, under purely monovalent salt conditions (K+, Na+), TALEs bind to spec

248 The phase transition occurs as monovalent salts are used to modify the ionic strength f

249 effect of trehalose to alter the activity of monovalent salts in aqueous solution.

250 own to bind selectively to the dockerin of a monovalent scaffoldin (ScaG), thus enabling formation of

251 nzymes either directly or through additional monovalent scaffoldins (ScaC and ScaD).

252 h a structurally related [Cp*Ir(biot-p-L)Cl].monovalent scdSav highlights the advantages of the prese

253 Monovalent scdSav thus provides a versatile scaffold to

254 d within the biotin-binding vestibule of the monovalent scdSav.

255 Switching from a monovalent scFv to a bivalent scFv-Fc format improved it

256 Bivalent mAb-TM was superior to monovalent scFv-TM in both pulmonary targeting and lung

257 Most viroporins are monovalent selective cation channels, with few showing t

258 Monovalent-selective Neosepta CMS is known to block diva

259 lter residue Gln973 is essential in defining monovalent selectivity.

260 ty filter may be an important determinant of monovalent selectivity.

261 Monovalent shells have a single radial defect, which is

262 implementation of the method in the case of monovalent (single binding site) Pproxy and monovalent a

263 ges, we report on our efforts to engineer a (monovalent) single-chain dimeric streptavidin (scdSav) a

264 Specifically, the monovalent sodium cation (Na(+)) has been known for deca

265 Surprisingly, monovalent sodium or ammonium ions, positioned in the pr

266 on on MWCNTs through bridging effects, while monovalent sodium reduced SRHA adsorption.

267 HD-MAPs were coated with a monovalent, split inactivated influenza virus vaccine co

268 native signaling conformation, leading to a monovalent "stapler," a single-chain variable fragment (

269 and green fluorescent protein, we show that monovalent Strep-Tactin is generally applicable to prote

270 We expect monovalent Strep-Tactin to be a reliable anchoring tool

271 of the interaction between Strep-tag II and monovalent Strep-Tactin were characterized.

272 e of biotin-streptavidin bonds, we find that monovalent streptavidin constructs with specific attachm

273 play equal enzymatic activities on a soluble monovalent substrate and similar substrate specificities

274 g hemagglutination inhibition (HI) data with monovalent swine antisera and antigenic cartography to e

275 Glycoconjugates containing stable, monovalent synthetic oligosaccharide analogs of ST-5 CPS

276 se events and have reasoned that designing a monovalent targeting strategy could circumvent the infla

277 This is the first monovalent transition metal dependent RNA-cleaving DNAzy

278 roprojection array, the Nanopatch, delivered monovalent type 2 IPV (IPV2) vaccine to the skin.

279 all infants were challenged with one dose of monovalent type 2 OPV (mOPV2).

280 After April 2016, monovalent type 2 OPV will be available for type 2 outbr

281 valent OPV (bOPV) and IPV and challenge with monovalent type 2 OPV, and stools samples were collected

282 on after a polio vaccination campaign with a monovalent type 2 oral polio vaccine (mOPV2).

283 Monovalent type 2 oral poliovirus vaccine (mOPV2) stockp

284 Infants in all groups were challenged with monovalent type 2 vaccine (mOPV2) at 18 weeks (groups 1,

285 Indian infants (aged 6-11 months) receiving monovalent type 3 OPV (CTRI/2014/05/004588).

286 earlier, had a greater interfering effect on monovalent type 3 OPV seroresponse than did persistent i

287 Indian infants who received a single dose of monovalent type 3 OPV.

288 However, monovalent UCA Fabs bound to MuSK but did not have measu

289 dy assessed the cost-utility of a first-dose monovalent (V) or quadrivalent (MMRV) followed by a seco

290 After monovalent vaccination, subjects developed high levels o

291 for H1N1; VE was 73% (61-81; I(2)=31.4) for monovalent vaccine against H1N1pdm09.

292 TCL derived from DENV monovalent vaccinees induced CD8 and CD4 T cells that cr

293 uced nAbs in volunteers who received the NIH monovalent vaccines against each DENV serotype.

294 mmunization with DENV1-4 VLPs as individual, monovalent vaccines elicited strong neutralization activ

295 The DENV1, 2, and 4 monovalent vaccines induced type-specific nAbs directed

296 pared to sera from guinea pigs receiving the monovalent vaccines, sera from guinea pigs receiving the

297 Experimental monovalent vaccines, which all utilize the sole envelope

298 rum antibodies recognized both the H1 and H3 monovalent vaccines.

299 tective mechanisms in animals immunized with monovalent versus polyvalent vaccines.

300 COMPASS is in part mediated by a new type of monovalent zinc finger (ZnF).