ライフサイエンスコーパス: mossy fiber

1 dant in the synaptic vesicles of hippocampal mossy fibers.

2 at arise from the rhombic lip and that issue mossy fibers.

3 HCN2 as the dominating subunit in cerebellar mossy fibers.

4 ct vestibular primary and secondary afferent mossy fibers.

5 s generated by antidromic stimulation of the mossy fibers.

6 ancelled by non-auditory signals conveyed by mossy fibers.

7 these consistent effects on Golgi cells and mossy fibers, ACh can either increase or decrease the sp

8 n of function begins with the segregation of mossy fibers across 10 distinct lobules over the rostroc

9 ignaling changed linearly with the number of mossy fiber action potentials.

10 term depression, single episodes of sprouted mossy fiber activation in hippocampal slices initiated b

11 ental networks, were transiently paired with mossy fiber activation in such a way that the two events

12 Patterned mossy fiber activity induces rhythmic Golgi cell activit

13 emerge in the granular layer in response to mossy fiber activity.

14 Moreover, the maturation of mossy fiber afferents from pontine neurons and the expre

15 Mossy fiber afferents to cerebellar granule cells form t

16 cell zones and the topographic targeting of mossy fiber afferents.

17 ediate heterosynaptic metaplasticity between mossy fiber and associational-commissural synapses.

18 conditioned using electrical stimulation of mossy fiber and climbing fiber afferents as CS and US, w

19 feedforward and feedback inhibition through mossy fiber and parallel fiber synapses.

20 r learning requires context information from mossy fibers and a teaching signal through the climbing

21 ings of motor corollary discharge signals in mossy fibers and granule cells provide direct evidence f

22 nflammation caused damage of the hippocampal mossy fibers and neuronal apoptotic death.

23 ion independently activates primary afferent mossy fibers and tertiary afferent climbing fibers that

24 proprioception are randomly mixed in spinal mossy fibers and that properties of granule cells are co

25 ain excitatory inputs of the cerebellum: the mossy fibers and the climbing fiber collaterals.

26 nuclei/spinal cord neurons that give rise to mossy fibers--and promotes GABAergic synapse formation a

27 However, the most prevalent targets of mossy fibers are GABAergic interneurons and SynCAM 1 los

28 eport that subthreshold potentials evoked by mossy fibers are sufficient to induce synaptic plasticit

29 Specifically, mossy fibers are thought to both directly excite nuclear

30 ate CN activity; collaterals of climbing and mossy fibers are two, and the remaining two are provided

31 uit often assume that input signals from the mossy-fibers are expanded and recoded to provide a found

32 tostimulation to mimic their excitation by a mossy fiber as it occurs in vivo.

33 stochemical (IHC) studies of the hippocampal mossy fiber axons and boutons using an antibody selectiv

34 tivity within granule cells was found within mossy fiber axons and giant synaptic boutons.

35 m channel gating and density in unmyelinated mossy fiber axons appear to be specialized for robust AP

36 oral lobe epilepsy, sprouting of hippocampal mossy fiber axons onto dentate granule cell dendrites cr

37 vesicular zinc activates TrkB in hippocampal mossy fiber axons under physiological conditions.

38 te to the pathologic retrograde sprouting of mossy fiber axons, both hallmarks of temporal lobe epile

39 brief trains of low-frequency stimulation of mossy fiber axons.

40 s drive retrograde sprouting of granule cell mossy fiber axons.

41 itical for generating PC protein stripes and mossy fiber bands, and that PC striped gene expression i

42 als such as the calyx of Held or hippocampal mossy fiber bouton.

43 Recordings from mouse cerebellar mossy fiber boutons show that HCN channels ensure reliab

44 o not change in adults, while presynaptic DG mossy fiber boutons undergo significant structural rearr

45 ed the length of the presynaptic membrane of mossy fiber boutons, associated with a de novo formation

46 subunit-containing GABA(A)Rs depolarized rat mossy fiber boutons, enhanced action potential-dependent

47 onversely, blocking GABA(A)Rs hyperpolarized mossy fiber boutons, increased their input resistance, d

48 tive two-photon Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high ra

49 unctional studies revealed a reduced size of mossy fiber boutons, with fewer synaptic vesicles and al

50 heterogeneous amplitudes observed in single mossy fiber boutons.

51 esulted in an increased volume of the axonal mossy fiber bundle projecting from dentate granule cells

52 Thus, STDP can bind plasticity to the mossy fiber burst phase with high temporal precision.

53 by modulating the frequency and duration of mossy fiber bursts, probably because STDP expression inv

54 ACh also reduces glutamate release from mossy fibers by acting on presynaptic muscarinic recepto

55 contrast to the CA3-CA1 pathway, LTP in the mossy fiber-CA3 projection did not depend on MMP-3, indi

56 Long-term potentiation of the mossy fiber-CA3 pyramid synapse was impaired in slices o

57 on plays a central role in plasticity at the mossy fiber-CA3 synapse of the hippocampus.

58 Thus, bidirectional NMDAR plasticity at mossy fiber-CA3 synapses could substantially contribute

59 bidirectional long-term NMDAR plasticity at mossy fiber-CA3 synapses in rat hippocampal slices.

60 on both P/Q- and N-type VGCCs at hippocampal mossy fiber-CA3 synapses, the specific contribution of V

61 ermits efficacious homeostatic adjustment of mossy fiber-CA3 synapses, while preserving synaptic weig

62 ffer collateral-CA1 synapses, but not at the mossy fiber-CA3 synapses.

63 suppressed PKC potentiation of NMDA EPSCs at mossy fiber-CA3 synapses.

64 h the induction of long-term potentiation at mossy fiber-CA3 synapses.

65 d by changes in short-term plasticity at the mossy fiber/CA3 circuit.

66 nsory and motor signals conveyed by distinct mossy fiber classes and (2) that Purkinje-like cells exh

67 In addition, we found that mossy fiber clustering, which is a common anatomical pat

68 Selective targeting of distinct mossy fibers determines how the cerebellum processes ves

69 orm of plasticity imparts bimodal control of mossy fiber-driven CA3 burst firing and spike temporal f

70 , we found that BDNF derived from excitatory mossy fiber endings controls their differentiation.

71 impacts both AMPA and NMDA components of the mossy fiber EPSC.

72 Long-term potentiation (LTP) of mossy fiber EPSCs in the cerebellar nuclei is controlled

73 This low-frequency potentiation of mossy fiber EPSCs requires postsynaptic mGlu1 receptors

74 an be released from these cells and modulate mossy fiber excitability through activation of GABAB aut

75 at facilitate filter construction are direct mossy fiber excitation of Golgi cells, variability of sy

76 ked phasic and spillover inhibition prior to mossy fiber excitation.

77 pyramidal cells, the targets of DGC-derived mossy fibers, exhibited normal morphologies with a small

78 orm modeling of sparse and filopodia-bearing mossy fibers, finding that these circuit features unique

79 Our results suggest that, although sprouted mossy fibers form recurrent excitatory circuits with som

80 erved alpha7 nAChR-mediated calcium rises at mossy fiber giant terminals, indicating the presence of

81 urons to determine the effect of nicotine on mossy fiber glutamatergic synaptic transmission.

82 lar layer, here, we shift attention onto the mossy fiber granule cell (GrC) relay.

83 t, helping to shape signal processing at the mossy fiber-granule cell relay.

84 f the alpha6 GABA(A) receptor subunit at the mossy fiber-granule cell synapse are perturbed, as well

85 ing at 6 Hz can optimally induce STDP at the mossy fiber-granule cell synapse in rats.

86 nal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is

87 ikes at 6-10 Hz reliably induced STDP at the mossy fiber-granule cell synapse, with potentiation and

88 Simple spikes (SSs) are often ascribed to mossy fiber-granule cell-parallel fiber inputs to Purkin

89 putative collateral branches terminating as mossy fibers in the cerebellar cortex.

90 r reorganization, including the sprouting of mossy fibers in the dentate gyrus; they establish aberra

91 the epileptic brain, inhibited sprouting of mossy fibers in the hippocampus, and prevented the progr

92 ression in loose clusters of spinocerebellar mossy fibers in the mouse AZ/PZ, whereas in rat CART imm

93 creased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice that lack vesicular z

94 In contrast, FXGs in hippocampal mossy fibers increased in abundance across development f

95 findings show that activation of hippocampal mossy fibers induces pre- and postsynaptic structural ch

96 imary conveyors of sensory and motor-related mossy fiber information to Purkinje cells.

97 ons and helps to expand the dynamic range of mossy fibers information transfer.

98 combinatorial diversity saturates quickly as mossy fiber input diversity increases, and that this sat

99 e cerebellum receives sensory information by mossy fiber input from a multitude of sources that requi

100 We found that theta-burst stimulation of mossy fiber input in lobule 9 granule cells lowered the

101 to regulate the response of granule cells to mossy fiber input in lobules 2 and 9 of the rat cerebell

102 ts, respectively, enabling dispersion of the mossy fiber input into its frequency components as perfo

103 e found that long-term potentiation (LTP) of mossy fiber input invoked a large increase in granule ce

104 Mossy fiber input is known to exhibit a long-term potent

105 elation of these subtypes to the response to mossy fiber input is not clear.

106 stsynaptic mechanisms contributing to LTP of mossy fiber input is unknown.

107 ular cerebellar cortex receive glutamatergic mossy fiber input on an elaborate brush-like dendrite.

108 drites received significantly more recurrent mossy fiber input through their apical dendrites, indica

109 tput became evident in response to bursts of mossy fiber input, revealing that Kv4 control of intrins

110 As granule cells receive mossy fiber input, they represent a key stage at which p

111 tely 2 ms before Purkinje cells, following a mossy fiber input.

112 ule cell activity as a function of timing of mossy fiber input.

113 anule cells (GrCs) sample approximately four mossy fiber inputs and are thought to form a combinatori

114 on whether individual granule cells receive mossy fiber inputs from multiple precerebellar nuclei or

115 Here we addressed whether mossy fiber inputs from the dentate gyrus onto CA3 princ

116 s support that SynCAM 1 modulates excitatory mossy fiber inputs onto both interneurons and principal

117 simulation, cessation of one of two ongoing mossy fiber inputs produces a robust temporal code in th

118 Cerebellar granule cells receive mossy fiber inputs that convey information on different

119 Using stimulation of mossy fiber inputs to the cerebellum as training stimuli

120 es spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing pattern

121 receive segregated and functionally distinct mossy fiber inputs, enabling Golgi cells to regulate the

122 rentially respond to high- and low-frequency mossy fiber inputs, respectively, enabling dispersion of

123 ex enabling a Fourier-like transformation of mossy fiber inputs.

124 codes the interval between the offset of two mossy fiber inputs.

125 acilitation, driven by strongly facilitating mossy fiber inputs.

126 pses and (2) long-term potentiation (LTP) at mossy fiber-interpositus nucleus synapses.

127 h more likely to send at least one recurrent mossy fiber into the molecular layer.

128 sensorimotor information carried by incoming mossy fibers is transformed before it is conveyed to Pur

129 Whereas the presynaptic form of mossy fiber long-term potentiation (LTP) was not affecte

130 cle pool distribution, impaired induction of mossy fiber long-term potentiation and deficits in hippo

131 splayed a major impairment in cAMP-dependent mossy-fiber long-term potentiation (LTP) in the CA3 regi

132 nstream effector of cAMP that contributes to mossy fiber LTP (MF-LTP), but the potential contribution

133 ufficient to impair the function of Syt12 in mossy-fiber LTP, suggesting that cAMP-dependent phosphor

134 l configurations for inducing and monitoring mossy-fiber LTP.

135 on serine-97 contributes to the induction of mossy-fiber LTP.

136 Mossy fibers make excitatory inputs onto postsynaptic sp

137 f sensory-motor context, which is encoded by mossy fiber (MF) activity.

138 to the distinct molecular properties of the mossy fiber (MF) and associational-commissural (AC) syna

139 ls (GrCs) and are driven both by feedforward mossy fiber (mf) and feedback GrC excitation.

140 The mossy fiber (MF) axons of the dentate granule cells conv

141 echanisms underlying information transfer at mossy fiber (mf) connections between the dentate gyrus (

142 (PFs) from granule cells (GCs) that receive mossy fiber (MF) input derived from precerebellar nuclei

143 n and are proposed to decorrelate convergent mossy fiber (MF) inputs in service of learning.

144 tivation of dentate gyrus PIIs by excitatory mossy fiber (MF) inputs induces Hebbian long-term potent

145 The mossy fiber (MF) pathway is critical to hippocampal func

146 ansmission and long-term potentiation of the mossy fiber (MF) pathway.

147 l in the hippocampal CA3 microcircuit is the mossy fiber (MF) synapse, which provides powerful direct

148 Hippocampal mossy fiber (MF) synapses on area CA3 lacunosum-molecula

149 CA3 region of the hippocampus, glutamatergic mossy fiber (MF) synapses onto CA3 pyramidal cells (PCs)

150 et-specific synapse formation at hippocampal mossy fiber (MF) synapses, which connect dentate granule

151 The hippocampal mossy fiber (MF) terminal is among the largest and most

152 sibility that the physiological diversity of mossy fiber (MF) to granule cell (GC) synapses in the mo

153 eceive a single glutamatergic synapse from a mossy fiber (MF), which makes them an ideal model to stu

154 ngs the kinetics of KAR-mediated currents at mossy fiber (MF)-CA3 pyramidal cell synapses.

155 r slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in the hippocampus.

156 The mossy fiber (MF)-granule cell (GC) pathway conveys multi

157 the hypothesis that zinc within vesicles of mossy fibers (mf) contributes to mf-LTP, a classical for

158 creased excitatory glutamate transmission at mossy fibers (MF)-CA3 synapses, and (2) an increased num

159 GoCs are excited by mossy fibers (MFs) and grcs and provide feedforward and

160 Electrical stimulation of mossy fibers (MFs) as well as microinjection of NMDA in

161 The mossy fibers (MFs) corelease glutamate and GABA onto pyr

162 dulloblastomas match the rhombic lip-derived mossy fiber neuronal lineage and embryonal tumors with m

163 ber projections to CA3 pyramidal cells place mossy fiber NMDARs in a prime position to influence CA3

164 Moreover, we found that mossy fiber NMDARs mediate heterosynaptic metaplasticity

165 gnatures of the specialized contacts between mossy fibers of dentate granule cells and thorny excresc

166 co-localize in the terminals of hippocampal mossy fibers, olfactory sensory neuron axons, and growth

167 odial extensions, demonstrating that not all mossy fibers originate from the dentate gyrus.

168 s short-term plasticity in a Purkinje cell's mossy fiber/parallel-fiber input pathways; 2) complex-sp

169 Local blockade of zinc or MAPK in the mossy fiber pathway of wild-type mice impairs contextual

170 astrocyte engagement in the fully developed mossy fiber pathway was slow and territorial, contrary t

171 ng to, or regulating, single synapses in the mossy fiber pathway.

172 xplore astrocyte activity in the hippocampal mossy fiber pathway.

173 entate gyrus and in its efferent fibers, the mossy fiber pathway.

174 gnals without a direct contribution from the mossy fiber pathway.

175 pmental gene expression characteristics with mossy fiber precerebellar nuclei that arise from the cau

176 uired more mushroom spines, and had enlarged mossy fiber presynaptic terminals.

177 However, unlike mossy fibers projecting to CA3, sprouted mossy fiber syn

178 nd disorganized infrapyramidal bundle of the mossy fiber projection from the dentate gyrus to CA3.

179 racing experiments showing the dentate gyrus mossy fiber projection, and its relationship to the intr

180 que functional properties of both NMDARs and mossy fiber projections to CA3 pyramidal cells place mos

181 In agreement, mossy fiber refinement in CA3 was impaired in SynCAM 1 K

182 Brush Cells (UBCs), which generate intrinsic mossy fibers relaying vestibular inputs to the cerebella

183 tability, optogenetic activation of sprouted mossy fibers reliably triggered action potential firing

184 ptic response with a subsequent subthreshold mossy fiber response induced long-term potentiation at C

185 istry for NKCC1, KCC2, and ectopic recurrent mossy fiber (rMF) sprouting as well as telemetric electr

186 organization of granular layer responses to mossy fibers shifted from a "Mexican hat" to a "stovepip

187 r brush cells (UBCs), which transform single mossy fiber signals into long-lasting excitation or inhi

188 the substrate for phase-dependent binding of mossy fiber spikes to repetitive theta-frequency cycles

189 with rapamycin displayed significantly less mossy fiber sprouting (42% of vehicle-treated animals),

190 ed DGCs exhibiting hilar basal dendrites and mossy fiber sprouting (MFS) when observed 4 weeks after

191 d status epilepticus in mice, would suppress mossy fiber sprouting and affect the development of spon

192 Furthermore, loss of tamalin blunts mossy fiber sprouting and dendritic arborization caused

193 In addition, mossy fiber sprouting and mossy cell death were correlat

194 However, correlations between the extent of mossy fiber sprouting and seizure frequency are weak.

195 t would not have been detected by markers of mossy fiber sprouting in previous studies include surviv

196 ycin (mTOR) signaling pathway and suppresses mossy fiber sprouting in rats.

197 on loss, abnormal neurogenesis, and aberrant mossy fiber sprouting in the dentate gyrus (DG).

198 These findings suggest mossy fiber sprouting is neither pro- nor anti-convulsan

199 on of adult-born granule cells to functional mossy fiber sprouting is unknown, primarily due to techn

200 in sea lions was unilateral in 79% of cases, mossy fiber sprouting was a common neuropathological abn

201 eactivity or Timm-stained, and the extent of mossy fiber sprouting was measured stereologically.

202 Global suppression of mossy fiber sprouting was not observed; however, ESNP-de

203 ossy fiber sprouting, although the effect on mossy fiber sprouting was reversible after stopping rapa

204 Consistent with mossy fiber sprouting, a higher proportion of glutamate-

205 apamycin decreased neuronal degeneration and mossy fiber sprouting, although the effect on mossy fibe

206 age of hilar ectopic DGCs, (2) the amount of mossy fiber sprouting, and (3) the extent of mossy cell

207 re hilar ectopic granule cells, mossy cells, mossy fiber sprouting, astrogliosis, and GABAergic inter

208 granule cells also contributed to functional mossy fiber sprouting, but exhibited less synaptic depre

209 ith TLE and evaluated graft differentiation, mossy fiber sprouting, cellular morphology, and electrop

210 ls, the number of mossy cells, the extent of mossy fiber sprouting, the extent of astrogliosis, or th

211 l as less severe astrogliosis and attenuated mossy fiber sprouting.

212 demonstrated that hilar EGCs contributed to mossy fiber sprouting.

213 ice in the absence of overt neuronal loss or mossy fiber sprouting.

214 persistent hilar basal dendrites (HBDs), and mossy fiber sprouting.

215 m mice, associated with abnormal hippocampal mossy fiber sprouting.

216 ctivity, spontaneous behavioral seizures, or mossy-fiber sprouting 5-6 weeks after mossy cell degener

217 way with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, inc

218 Granule cell axon (mossy fiber) sprouting is a common neuropathological fin

219 KAR LTD is induced by high-frequency mossy fiber stimulation and natural spike patterns and r

220 poral fidelity of granule cell spikes during mossy fiber stimulation.

221 hat capillary diameter changes rapidly after mossy fiber stimulation.

222 ied glutamatergic synapses of the brain, the mossy fiber synapse of the hippocampus.

223 formation and differentiation of the DG-CA3 mossy fiber synapse.

224 Mossy fiber synapses act as the critical mediators of hi

225 Mossy fiber synapses are assumed to exhibit presynaptic

226 well as presynaptic short-term plasticity at mossy fiber synapses are unaltered at 6 months in APP/PS

227 nitor fine-structural changes at hippocampal mossy fiber synapses associated with chemically induced

228 bserved at CA3 associational/commissural and mossy fiber synapses but not CA1 Schaffer collateral syn

229 ike mossy fibers projecting to CA3, sprouted mossy fiber synapses depress upon repetitive activation.

230 Mossy fiber synapses exhibit both pronounced short-term

231 llel we performed a morphometric analysis of mossy fiber synapses following viral based labeling and

232 to technical barriers in isolating sprouted mossy fiber synapses for analysis.

233 d frequency-dependent facilitation, sprouted mossy fiber synapses from adult-born cells exhibited pro

234 We directly activated sprouted mossy fiber synapses from adult-born granule cells to st

235 We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mo

236 urthermore, we tested synaptic plasticity of mossy fiber synapses in area CA3 and found increased lon

237 Surprisingly, however, although healthy mossy fiber synapses in CA3 are well characterized "deto

238 creased probability of release compared with mossy fiber synapses in CA3.

239 Here, we discovered that mossy fiber synapses in the mouse cerebellum homeostatic

240 Remarkably, PTP switched mossy fiber synapses into full detonators for tens of se

241 t post-tetanic potentiation at dentate gyrus mossy fiber synapses is induced by natural activity patt

242 ed, the connexin-36-containing glutamatergic mossy fiber synapses of the rat hippocampus express prev

243 Mossy fiber synapses on CA3 pyramidal cells are 'conditi

244 xcite target neurons, the impact of sprouted mossy fiber synapses on hippocampal hyperexcitability is

245 ic transmission (KAR LTD) at rat hippocampal mossy fiber synapses relieves inhibition of the sAHP by

246 pre- and postsynaptic structural changes at mossy fiber synapses that can be monitored by EM.

247 However, at hippocampal mossy fiber synapses, RIM-BP2 has a substantial impact o

248 This suggests that mossy fiber synapses, which play a major role in learnin

249 ontextual memory and long-term plasticity at mossy fiber synapses.

250 m NMDA receptor-independent LTP of local CA3 mossy fiber synapses.

251 ted synaptic transmission at rat hippocampal mossy fiber synapses.

252 long-term potentiation (LTP) at hippocampal mossy fiber synapses.

253 cellular substrate for expression of LTP at mossy fiber synapses.

254 nd GABAergic cells similarly to conventional mossy fiber synapses.

255 ) receptors (GABA(A)Rs) occur at hippocampal mossy fiber synapses.

256 ential for cAMP-dependent presynaptic LTP at mossy-fiber synapses, and a single amino-acid substituti

257 hat locomotion can be directly read out from mossy fiber synaptic input and spike output in single gr

258 ranule cells, which may result from abnormal mossy fiber synaptic plasticity.

259 A decreasing gradient of mossy fiber synaptic strength along the proximodistal ax

260 A-knockin impaired the long-term increase in mossy-fiber synaptic transmission induced by forskolin.

261 These results implicate the mossy fiber-TE synapse as an independently tunable gain

262 Although mossy fiber terminals (MFTs) are known to express glutam

263 tial patterns of calcium elevations in giant mossy fiber terminals and support short-term facilitatio

264 rain sections from both mice and rats showed mossy fiber terminals as a group of large (2-5 mum in di

265 Hippocampal giant mossy fiber terminals display extensive short-term facil

266 GABA is released as a neurotransmitter from mossy fiber terminals during development.

267 labeled somata in the cerebellar nuclei and mossy fiber terminals in the cerebellar granule layer, c

268 Though, how giant mossy fiber terminals leverage distinct types of voltage

269 that, in the developing rodent hippocampus, mossy fiber terminals release GABA together with glutama

270 Postsynaptic targets of all labeled mossy fiber terminals were identified using immunohistoc

271 terminals in the same area where identified mossy fiber terminals were present.

272 CA3 granule cell axons displayed giant mossy fiber terminals with filopodial extensions, demons

273 ere the major target of resulting disynaptic mossy fiber terminals, but we also found at least sparse

274 activation of the Erk1/2 MAPK in hippocampal mossy fiber terminals, disinhibition of zinc-sensitive M

275 rebellar modules we found spatial overlap of mossy fiber terminals, originating from functionally dis

276 the morphological characteristics of typical mossy fiber terminals, the functional characteristics of

277 ssing some of the morphological hallmarks of mossy fiber terminals.

278 pDOR-ir was less frequently found in mossy fibers terminals.

279 se AZ/PZ, whereas in rat CART immunoreactive mossy fibers terminated predominantly in the CZ/NZ.

280 Mossy fiber termini in the hippocampus accumulate Zn(2+)

281 t long-term potentiation induction at single mossy fiber termini of dentate gyrus neurons in adult mo

282 ded into presynaptic vesicles in hippocampal mossy fiber termini upon KCl-induced depolarization, whi

283 xcitatory postsynaptic potential evoked by a mossy fiber that enhances NMDA receptor-mediated current

284 in axons and synaptic boutons of hippocampal mossy fibers, thereby implicating BDNF in activation of

285 and morphological maturation of hippocampal mossy fiber to CA3 pyramidal cell (mf-CA3) synapses is d

286 Excitatory synaptic strength at mossy fiber to CA3 pyramidal cell synapses is potentiate

287 A well established property of mossy fiber to CA3 pyramidal cell synapses is the extens

288 Glutamate spillover in the mossy fiber to granule cell cerebellar glomeruli has bee

289 the mossy fiber to nuclear cell synapse and mossy fiber to granule cell synapse.

290 ings of learning related potentiation at the mossy fiber to nuclear cell synapse and mossy fiber to g

291 ion of Purkinje cells, and plasticity at the mossy fiber to vestibular nuclei neuron synapse.

292 2 are necessary for the precise targeting of mossy fibers to distinct lobules, as well as their subse

293 t zinc modulation extends beyond hippocampal mossy fibers to excitatory SC-CA1 synapses.

294 However, at the mossy fiber-to-unipolar brush cell synapse in the cerebe

295 SIGNIFICANCE STATEMENT: The mossy fibers transiently corelease glutamate and GABA on

296 enhancing synaptic efficiency of hippocampal mossy fiber transmission.

297 NT The common assumption that all cerebellar mossy fibers uniformly collateralize to the cerebellar n

298 Moreover, the number of new mossy fiber varicosities in these parts of the cerebella

299 but that the BDNF protein is present within mossy fibers which originate from cells located outside

300 s through aberrant sprouting of their axons (mossy fibers), which is found in many patients and anima