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1 ation depending on its C-terminal activation motif.
2 ingle regulatory factor or promoter sequence motif.
3 the phosphatase via a conserved short linear motif.
4 genes predicted to be regulated via an ER-2 motif.
5 a 24-kDa brain-enriched protein with a SNARE motif.
6 and directly dephosphorylates the T788/T789 motif.
7 r gene due to the absence of a Keap1-binding motif.
8 transcriptional coactivator with PDZ-binding motif.
9 effects of nucleotides beyond the core CTCF motif.
10 ndensation to deliver the (dihydro-)pyridone motif.
11 et sequence in tandem with the APT silencing motif.
12 containing a highly conserved twin-arginine motif.
13 diates stable binding to a non-canonical DNA motif.
14 ch we previously identified as a CDK-binding motif.
15 ntain the pyrrolodiketopiperazine structural motif.
16 site defined by a conserved Asp-His-His-Cys motif.
17 richment of the transcription factor binding motif.
18 ated by affinity and position of B56 binding motifs.
19 ould be an ideal approach to construct these motifs.
20 ing (SMC), resulting in new-to-nature biaryl motifs.
21 Pyridine rings are prominent amongst these motifs.
22 reshold followed by a list of glycan-binding motifs.
23 ory sequences and transcription factors (TF) motifs.
24 l regions at Serine/Threonine-Glutamine (SQ) motifs.
25 including proapoptotic genes, have weak ISRE motifs.
26 lux via phosphorylation at conserved, shared motifs.
27 anonical surface-exposed Tyr-based endocytic motifs.
28 oding regions near known amoxicillin binding motifs.
29 tangle reciprocal and feedforward-inhibitory motifs.
30 ding of suramin to the "AT-hook" DNA-binding motifs.
31 tion of high- and low-temperature structural motifs.
32 ions with non-canonical protospacer-adjacent motifs.
33 nd the synthesis of complex antennary glycan motifs.
34 tors that predominantly bind exonic splicing motifs.
35 aining logic gates linked to self-immolative motifs.
36 Ps can bind to multiple distinctly different motifs.
37 sed immunogens displaying complex structural motifs.
38 folds and conformity to conserved structural motifs.
39 y between financial incentives and intrinsic motives.
41 CA2;3, a binding partner of CDKB1;1, via SIM motif A, which we previously identified as a CDK-binding
42 r overall architecture and phosphate binding motif, a lack of sequence identity and some fundamental
43 utations of Ets or E-box sites in either DNA motif abolished the activation and reduced or eliminated
47 eract with Atg8a using four Atg8-interacting motifs (AIMs) located at the C-terminus, cytoplasmic loo
49 generated mice with an inactivated mIgE-ITT motif and analyzed serum IgE levels as well as the gener
52 inhibition between ChINs is a robust network motif and instrumental in shaping the network activity o
53 nique hydrogen peroxide (H(2) O(2) )-sensing motif and its capacity for providing cellular protection
56 ely remained conserved in canonical sequence motifs and copy numbers as in E. maclovinus, showing lim
57 nces containing their respective DNA-binding motifs and identify preferential motif arrangements that
58 cture that recognizes linear phosphotyrosine motifs and is present in a wide range of signaling pathw
59 nt concepts to eliminate unwanted structural motifs and to improve the inhibitor characteristics of t
60 ealed that the RILP algorithm selected fewer motifs and was able to cover 6% more peaks and 3% fewer
61 regions were strongly enriched for the AP-1 motif, and indeed, ChIP-seq demonstrated AP-1 binding at
62 ed MamY and the actin-like MamK via distinct motifs, and with the cell shape-related cytoskeleton via
72 ype of C(60/70) host where electron-rich PDI motifs are utilized as recognition motifs for fullerenes
75 , 9, and 13 to validate the vicinal difluoro motif as a hybrid bioisostere of CF(3) and Et (BITE) in
76 ally challenging spirocyclic tetrahydrofuran motif as well as several other key stereochemical proble
77 s9-independent off-targeting and point to TC motifs as activity hotspots of the cytidine deaminase us
79 ere by demonstrating that the analogous ATF4 motif at the murine Bcl11a enhancer is largely dispensab
80 ples a graph mining-based strategy to detect motifs at the protein-ligand interface with an interacti
81 e targeting probability of a nucleotide in a motif-based fashion, assuming that the same DNA motif is
82 MBC-like WM hypomethylation was enriched in motifs belonging to PU.1, TCF3, and OCT2 transcription f
83 esults demonstrate that although some common motifs between the HIV-1 Vif and MVV Vif are involved in
85 ximately 70% of RBPs for which we obtained a motif bound to short linear sequences, whereas ~30% pref
88 Our results demonstrate that simple sequence motifs can rigidify elementary membrane proteins, and th
89 conferred by low affinity pMad/Medea binding motifs, can contribute to the specification of BMP targe
91 ecies, and the presence of the canonical CDK motif, CDKB emerged as a likely candidate for a Saccharo
92 asin P672 that physically interacts with C-C motif chemokine ligand (CCL) 8 and synthesized a 16-mer
94 +) T cells through the downregulation of C-C motif chemokine receptor 5 (CCR5) in T cells and CD4 in
96 forward inhibition was weakened, and the two motifs combined to modulate fusiform cell output and aco
97 ferential genomic regions, identifying E-box motifs common to epithelial-mesenchymal transition drive
98 ical studies of single WW domain-single PPXY motif complexes abound in the literature, the molecular
99 in vitro confirmed that residues in sequence motifs conserved across bacterial and eukaryotic ortholo
100 he development of miCas9 by fusing a minimal motif consisting of thirty-six amino acids to spCas9.
101 sequences are predicted to have possible NES motifs containing cancer-related mutations at their key
102 ial homolog of transmembrane BAX inhibitor-1 motif-containing 6 (TMBIM6) membrane protein that plays
104 terile alpha and Toll/interleukin-1 receptor motif-containing protein 1 (SARM1) is a central regulato
105 scope with all six-carbon-substituted arene motifs, control experiments, and gram-scale synthesis ma
111 ine that variants of the TOP domain finger 1 motif destabilizes the channel structure and impairs cha
115 ibitor Sic1, contains linear phosphorylation motifs, docking sites, and phosphodegrons to empower an
116 ion, while cluster binding to the N-terminal motif does not affect the quaternary structure of NUBP1.
117 e find that the arginine residue in the FLVR motif does not directly contact pTyr(1087) of a bound ph
118 pentaloop is recognized by the sterile alpha motif domain-containing ZCCHC14 protein, which in turn r
121 ntibodies (Abs) against phosphotyrosine (pY) motifs embedded in folded polypeptides remains highly ch
122 u-721, and Leu-725, that are part of a novel motif, EXEXXXL(725), critical for PC7 activity on hTfR1.
123 these data demonstrate that discrete glycan motifs expressed on CD11b/CD18 such as biantennary galac
125 ke (S) glycoprotein exhibits a high-affinity motif for binding TCRs, and may form a ternary complex w
126 lular N terminus, which contains the binding motif for endogenous Src tyrosine kinase that constituti
129 -rich PDI motifs are utilized as recognition motifs for fullerenes, facilitating novel intermolecular
130 extracellular loops as important structural motifs for ion selectivity and channel inhibition in Pan
133 many CAPs associate, although each contains motifs for only a minority of the numerous associated tr
135 ulators, which often feature carboxylic acid motifs for target engagement, have emerged as a class of
136 expand the current catalogue of DNA sequence motifs for transcription factors, and describe motifs th
137 ted whether retributive and consequentialist motives for punishment are present in children approxima
141 ture exhibits similarity to eIF3 recognizing motifs found in hepatitis C virus (HCV)-like IRESs, sugg
142 residues from CTD and the His-Cys-His (HCH) motif from the N-terminal segment of the neighboring sub
145 G6) and lysine (K7) residues of the Walker A motif (-GPAGTG(6)K(7)S-) were found to be critical to th
146 since the relevant PLK1 and PP2A-B56 binding motifs have coevolved in the same region on MADBUB homol
147 d Galpha(q) These findings indicate that GBA motifs have versatility in their G-protein-modulating ef
148 yotic cell division, cyclin-specific docking motifs help cyclin-dependent kinases (CDKs) phosphorylat
149 is a powerful tool for accessing structural motifs, highly desirable by the pharmaceutical industry.
150 etion of Cav-1 scaffold domain binding (CSD) motif in EphB1 prevented EphB1 binding to Cav-1 as well
151 side chain of Glu89 (located along the arch motif in hExo1) flips frequently from the reactant state
152 ha-Linked galactose is a common carbohydrate motif in nature that is processed by a variety of glycos
153 yristoylation signal and the C-terminal FXXF motif in PKAc regulate its thermal stability and catalys
157 YAP association with the TEA domain-binding motif in the promoter region of inflammatory cytokines.
158 es and establishing links between structural motifs in a catalyst, local electronic structure, and ca
160 X for short, to bind certain DNA recognition motifs in gene promoters that regulate gene expression.
161 form to visually explore and interpret these motifs in the context of protein-ligand interfaces.
162 e demonstrate that the integrity of the CCHC motifs in the Gag NC domain is dispensable for Alix-medi
163 analyze paired transcription factor binding motifs in the promoters of cell type-specific genes.
164 er-to-order transition of the ankyrin repeat motifs in the substrate binding domain of cpSRP43 drives
168 These k-mers represented the characteristic motifs (in the form of a collection of conserved short p
169 containing Ga-arene and Ga-OTf coordination motifs, in addition to an unusual "naked" [Ga](+) ion, a
171 rks, consisting of multiple forms of circuit motifs including reciprocal (inhibitory interneurons inh
173 e B analogues equipped with novel structural motifs, including fluorine-containing residues, 12,13-di
174 ruption of TF (transcription factor)-binding motifs, inferred from alternative alleles at the haQTLs,
176 ted, only the bromodomain and extra-terminal motif inhibitor CPI203 enhanced the expansion of human c
178 otein interactions using the conservation of motifs, interology, or presence or absence of key sequen
179 gether, our data argue that the high mannose motif is an infection-associated molecular pattern on ho
181 if-based fashion, assuming that the same DNA motif is equally likely to be targeted regardless of its
182 We found that the KSHV gH (ELEFN(50-54)) motif is important for higher KSHV fusion and that EBV g
187 Our findings indicate that the twin-His motif is the core structure responsible for substrate de
188 relative prevalence of different reciprocity motives is highly stable across participant samples.
189 ng these families, the X position in the CXC motif, is not predicted to make significant contacts wit
192 of the CNN confirmed it detects familiar DNA motifs known to correlate with real variation, like homo
194 isomerization of, Kv4.2 at the pThr(607)-Pro motif, leading to the dissociation of the Kv4.2-DPP6 com
195 4, and PAR1:CXCR4 heteromers, chemokine (CXC motif) ligand 12 stimulation reduced surface expression
196 ecede or are independent from chemokine (C-C motif) ligand-CCR2 signaling in the development of age-r
198 ructure incorporating a protonated hydrazone motif linked to the 1,2,5-oxadiazole 2-oxide subunit was
202 s through increasing the accessibility of TF motifs NR1H4 and OLIG (OLIGI and OLIG2), respectively.
204 However, unlike synaptrobrevin-2, the SNARE motif of amisyn is not sufficient to account for the rol
206 inpointed Met-1669 as the residue in the GBA motif of DAPLE that diverges from that in GIV and enable
207 the interface of 14-3-3 with the recognition motif of either the tumor suppressor protein p53 or the
209 inhibits I(Kv1.5) Disrupting the Src-binding motif of Kv1.5 through N-terminal truncation or mutagene
210 4Fe-4S](2+) cluster formed at the N-terminal motif of NUBP1 is tightly bound, while the [4Fe-4S](2+)
211 s process, cluster binding to the C-terminal motif of NUBP1 promotes protein dimerization, while clus
213 ingle nucleotide mutation of m(6)A consensus motif of viral RNAs enhances RIG-I sensing activity.
217 his allowed us to characterize DNA consensus motifs of early and late ASFV core promoters, as well as
219 issue-specific NFR were enriched for binding motifs of transcription factors related to tissue-specif
220 d ability to sequence homopolymers, repeated motifs or long-range structural variation, and long-read
221 lexibility of the linker between two binding motifs, our results suggest that the conformational fluc
222 l screens to assess the protospacer adjacent motif (PAM) and guide RNA (gRNA) requirements of 79 Cas9
223 ers and the cleavage of protospacer adjacent motif (PAM) in several type I CRISPR-Cas systems, but ho
225 to contain any specific protospacer-adjacent motifs (PAM); is a multi-turnover enzyme; cleaves ssDNA,
227 , TEs abundant in these regions and carrying motifs potentially beneficial for enhancer architecture
228 rate that FDL1 directly binds to CCAACC core motifs present in AD1 regulatory regions to activate its
229 that k-gram statistics with visibility graph motifs produce fast and accurate classifications, highli
230 Although conventionally defined as AG-rich motifs, recent genomic surveys reveal great sequence div
231 and it is not known whether the plant lysin-motif receptor-like kinase MtLYK10 intervenes in recogni
232 s of natural and engineered chemokine (C-X-C motif) receptor 4 (CXCR4) agonists in a rat acute respir
233 ouble-sized defensin, predicted to possess 2 motifs related to beta-defensins and 6 disulfide bridges
236 s in cells reveal that LD targeting of these motifs requires deeply inserted tryptophans that have lo
237 We solved separate NMR structures of the IQ motif (residues 1,646-1,664) bound to alpha-actinin-1 an
238 star possessing three and six cavitand-based motifs, respectively, demonstrates that such self-assemb
239 g dsDNA and DNA strand separation by the ThM motif, revealing an unconventional DNA unwinding mechani
241 e arginyl-glycyl-aspartic acid cell adhesion motif RGD, which can be used as coating, but can also be
242 we report a mutation in the RNA recognition motif (RRM) of CSTF2 that changes an aspartic acid at po
245 amming suggests a correlation of recognition motif sequence and spacing that may distinguish producti
247 to a central core region that depends on the motif sequences of our previously nominated driver DAPs.
248 18 ULK1-specific and 7 ULK2-specific protein motifs serving as different interaction interfaces.
250 terminal region containing SUMO Interactions Motifs (SIMs) required to bind SUMO modified substrates.
253 phase separation reduces the requirement for motif specificity and expands the repertoire of substrat
255 dentifies a GC-rich region as SERBP1-binding motif; subsequent genomic and functional analyses establ
256 ns also carry multiple "AT-hook" DNA-binding motifs, suramin is expected to inhibit HMGA1-DNA interac
257 Phosphorylation of a conserved threonine motif (T788/T789) in the integrin beta cytoplasmic domai
258 transcriptional coactivator with PDZ-binding motif (Taz), two transcriptional coactivators known to b
259 (PX) domain of SNX5 or SNX6 and a bipartite motif, termed SNX-BAR-binding motif (SBM), in the cargoe
260 4A1 has a functional destruction box (D-box) motif that allows binding with two APC adaptors, CDC20-h
263 membrane proteins contain conserved sequence motifs that are known to be important in helix packing.
264 heir function and elucidating key structural motifs that can be targeted for therapeutic regulation.
266 tifs for transcription factors, and describe motifs that correspond to other transcription factors th
269 ng a conformation that can bind specific DNA motifs, thereby serving to either activate or repress tr
271 us NPs contain a highly conserved DEDDh ExoN motif, through which LASV NP degrades virus-derived, imm
272 ze with a speckle-associated RNA recognition motif to promote speckle specificity and residence.
274 us subcellular regions via sequence specific motifs to measure spatiotemporal changes in ERK activity
275 mmalian reovirus, mimic extracellular matrix motifs to specifically interact with the host membrane.
276 ITAM, ITIM or ITSM tyrosine phosphorylation motifs to the promiscuous cell-surface phosphatase CD45(
277 agement between RNA helicases and tripartite motif (TRIM) E3 ligases that lead to their functional co
278 polyglutamine-adjacent ubiquitin-interacting motifs (UIMs) that enhance aggregation and toxicity.
282 e specifically, mutations T407A and S411A in motif V exhibit a hyperactive helicase phenotype, leadin
285 tecture, carrying five molecular beacon-like motifs, was constructed to display ten dengue envelope p
287 The confidently identified NES candidate motifs were checked for overlap with cancer-related muta
288 -stimulated response element (ISRE) promoter motifs, whereas the expanded set of type I IFN-specific
289 g the informational content of functional HS motifs which is crucial for their future biomedical expl
290 factor (TF) binding by mutating a TF binding motif, which in turn may affect the activity of the regu
292 it is clear that changing a protein binding motif will alter protein binding, it has been shown that
293 rystal structure of the W C-terminal binding motif with 14-3-3 provides only the second structure of
295 ion hubs, it contains repeated neurochemical motifs with distinct inputs: GABA-rich modules are inner
297 dotoxin, indicating that targeting of DVRGLL motif within MYLK-L may limit SOCE-induced vascular hype