ライフサイエンスコーパス: motivational

1 This study strengthens the motivational account of methylphenidate's effects on cog

2 to a treatment condition, in which they gave motivational advice (e.g., how to stop procrastinating)

3 d field experiment, we tested whether giving motivational advice raises academic achievement for the

4 o achieve their goals benefit from receiving motivational advice.

5 esearch is needed to pinpoint the cognitive, motivational, affective, and social processes that under

6 ence, contributing to numerous emotional and motivational alterations related drug taking, seeking, a

7 a strong association between depression and motivational alterations, we sought to (1) characterize

8 higher cognitive functions with and without motivational and affective significance; and in a subgro

9 Alterations in reward processes may underlie motivational and anhedonic symptoms in depression and sc

10 the technological reserve hypothesis, social-motivational and cultural transmissibility factors can p

11 unselected populations enables a read-out of motivational and decision variables not emphasized by in

12 sed in brain areas involved in regulation of motivational and emotional processes.

13 le outcomes relates to plasticity in visual, motivational and executive corticostriatal circuits.

14 Motivational and motor deficits are common in patients w

15 dopaminergic treatment strategies to improve motivational and motor deficits in patients with increas

16 Motivational and NAc dopaminergic deficits were not asso

17 ll ultimately lead to improved treatment for motivational and psychomotor symptoms in psychiatry and

18 Together, these findings suggest motivational and valence processing systems interact to

19 on of food, thereby increasing its incentive-motivational and/or hedonic properties and driving consu

20 posure on foraging performance may be due to motivational and/or sensory impairments.

21 dopamine neurons, which modulate cognitive, motivational, and affective behaviors, are involved in T

22 cterizes habits in terms of their cognitive, motivational, and neurobiological properties.

23 Motivational anhedonia, the failure to translate positiv

24 eactivity from hedonic reward outcome to the motivational anticipatory cue yielding more habitual cue

25 Existing among other motivational approaches, the concepts in behavioural eco

26 opaminergic circuitry, where it can increase motivational aspects of feeding behavior through effects

27 ieval interventions can reduce the emotional/motivational aspects of memories, without actually erasi

28 a conceptual shift that links cognitive and motivational aspects of schizophrenia and that can lead

29 set of behavioral alterations; however, its motivational aspects remain poorly explored in humans.

30 the consequences of potential differences in motivational behavior between individuals.SIGNIFICANCE S

31 rther investigate effects of inflammation on motivational behavior in psychiatric and chronic illness

32 (LPS) affected two dissociable constructs of motivational behavior, ie, effort and reward sensitivity

33 rocessing of physiologic state to VTA-driven motivational behavior.

34 ated accumbal dopamine release help regulate motivational behavior.

35 nto-striatal system, which is known to drive motivational behavior.

36 een their activities determining the type of motivational behavior.

37 in cognitive processes, including affective motivational behaviors and hippocampus (HPC)-dependent m

38 ciceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of

39 rior temporal regions involved in social and motivational behaviors, and more functionally connected

40 and the neuromodulatory circuits that govern motivational behaviors.

41 es interactions between individual cognitive-motivational biases and the form of the drug cue encount

42 Such motivational biases have been proposed to reflect cue-ba

43 Here, we assess whether motivational biases may also arise from asymmetrical ins

44 Computational analyses showed that motivational biases reflect both Pavlovian and instrumen

45 mmation induced by LPS administration causes motivational changes in young healthy subjects, which ar

46 terations, we sought to (1) characterize the motivational changes that are associated with inflammati

47 ness but might also account for maladaptive, motivational changes that underpin the association betwe

48 rs many context-appropriate actions, but the motivational characteristics of orexin cell activity rem

49 bstrate for ILPFC/BA25 linking affective and motivational circuitry dysfunction in MDD.

50 PGE2-mediated modulation of the dopaminergic motivational circuitry is a key mechanism underlying the

51 These findings show that subcortical motivational circuits are important in guiding explore-e

52 ction represents a dramatic dysregulation of motivational circuits that is caused by a combination of

53 etabolic hormones stabilize brain reward and motivational circuits, whereas excessive opioid consumpt

54 neural mechanisms that directly modulate the motivational component of aggressive behaviour.

55 Further, they indicate that the motivational component of inflammation-induced depressio

56 e-of-day and circadian effects under maximal motivational conditions.

57 neral motor activity were measured under two motivational conditions: food-deprived rats given standa

58 Decision-making often involves motivational conflict because of the competing demands o

59 intensity, but in both cases only if a high motivational conflict was present.

60 thalamus (PVT) in behavioral control during motivational conflict.

61 and determine the behavioral response during motivational conflict.

62 n of appetitive and aversive behavior during motivational conflict.

63 PVT as central to behavioral control during motivational conflict.SIGNIFICANCE STATEMENT Animals, in

64 l required to flexibly negotiate response or motivational conflicts and override prepotent behaviors.

65 eptual pain modulation by varying degrees of motivational conflicts and the role of subjective utilit

66 frameworks attest to the indispensability of motivational considerations to the epistemic process.

67 al for movements toward reward in a positive motivational context but suppress movements in an aversi

68 n V1 depending on the animal's behavioral or motivational context, complementing other known state-de

69 on of individual feeding bouts regardless of motivational context.

70 Such motivational "context-contamination" leads to voluntaril

71 ons selectively control behavior in opposing motivational contexts.

72 willpower as the perceiving or formation of motivational contingencies that outweigh the temptation,

73 f unique valence and provide state-dependent motivational control [1].

74 pression and impulsivity, related to reduced motivational control.

75 muli induce a time-dependent increase in the motivational craving state (incubation of craving).

76 Catecholamines modulate the impact of motivational cues on action.

77 Motor dysfunction (e.g., bradykinesia) and motivational deficit (i.e., apathy) are hallmarks of Par

78 omotor activity, lower baseline anxiety, and motivational deficits in operant conditioning for palata

79 her altered NAc dopamine release accompanies motivational deficits in the Q175 knock-in HD mouse mode

80 Here, we tested whether motivational deficits observed in mice with upregulated

81 sfunction, we show that iuGC animals present motivational deficits that are rescued by selective opto

82 ical to goal-directed behaviors, accompanies motivational deficits, one of the most common early HD s

83 al conditions are characterized by motor and motivational deficits, which both result in reduced beha

84 predicted clinical improvement in motor and motivational deficits.

85 smission at D2-MSN-to-VP synapses normalized motivational deficits.

86 high-agency environments indicates a salient motivational dimension.

87 ucleus accumbens has been argued to underlie motivational disorders such as depression, and many prom

88 apeutic efficacy of CBD for the treatment of motivational disorders such as drug addiction, anxiety,

89 BA(B)R-selective pharmacotherapy for various motivational disorders, including addiction, major depre

90 NP is mediated by a motivational dopamine signal that increases in response

91 We further found that as motivational drive decreases throughout a session, the a

92 ted behavior, but it remains unclear whether motivational drive is linked to discrete neurobiological

93 e) can depend on the temporal primacy of one motivational drive relative to the onset of a competing

94 ned by an appeal to "incentive hope" and the motivational drive toward consumption triggered by the f

95 sory integration, behavioral output control, motivational drive, and neural plasticity.

96 halamic circuits linking energy state to the motivational drive, hunger, and, finally, limbic and cog

97 ior in the continued presence of a competing motivational drive, such as threat avoidance, or whether

98 r impairment and could be overcome by strong motivational drive.

99 ce [1] but also on the presence of competing motivational drives [2] and learned cues signaling food

100 Physiological needs produce motivational drives, such as thirst and hunger, that reg

101 of possible states corresponding to discrete motivational drives.

102 ip as a system to study these long-timescale motivational dynamics.

103 dge about the neural basis of effort-related motivational dysfunction, and it is hoped that this rese

104 ng in psychiatric conditions associated with motivational dysfunction.

105 d patient navigation (barrier assessment and motivational education for patients who declined screeni

106 logical and neural mechanisms underlying the motivational effect of curiosity.

107 ced inhibitory response control and a larger motivational effect on performance in ADHD already at th

108 These findings demonstrate that the motivational effects of inflammation do not require IDO1

109 Yet the motivational effects of paired CeA stimulation can be re

110 Motivational effects were indexed by pupillometry and sa

111 explain why uncertain rewards produce strong motivational effects.

112 ergic neural substrates mediate the negative motivational effects.

113 ion of the lateral hypothalamus (LH) has two motivational effects: long trains of stimulation induce

114 ve eating through the integration of complex motivational, emotional, and cognitive constructs is war

115 ted performance is fundamental to C and that motivational engagement, behavioral restraint, and envir

116 dults with alcohol dependence and engaged in motivational enhancement therapy affects drinking outcom

117 step 2, addiction physician management plus motivational enhancement therapy, comprising four sessio

118 econd week of a 5-week outpatient regimen of motivational enhancement therapy.

119 n persons with alcohol dependence engaged in motivational enhancement therapy.

120 out infants' ability to reason about agents' motivational, epistemic, and counterfactual states.

121 As a key motivational example, we have implemented the proposed f

122 synergism between both representational and motivational factors and is unlikely to be accounted for

123 ecision-making task, allowing us to rule out motivational factors and isolate the role of uncertainty

124 ensitivity to a broad array of cognitive and motivational factors have meant it is commonly viewed as

125 minimal research has addressed understanding motivational factors key to self-management behaviors.

126 unclear whether this is due to cognitive or motivational factors.

127 al physiological state of the body influence motivational feelings and action decisions.

128 of synaptic AMPA receptors that enhance the motivational for cocaine.SIGNIFICANCE STATEMENT Dopamine

129 The motivational force of social mobilization is amplified b

130 sly, we showed that aripiprazole may protect motivational function by preserving reinforcement-relate

131 much deeper understanding of the breadth of motivational function.

132 ditation not only improves our cognitive and motivational functioning (e.g., attention, mental health

133 ic decision theory, to dissect the motor and motivational functions of dopamine in humans.

134 Considering the cognitive and motivational functions of gender stereotypes helps us un

135 ort, which is employed for both learning and motivational functions.

136 ue-P3 and Nogo-P3), which were recorded in a motivational go/nogo task, indicated diminished attentio

137 um and caudate, striatal nodes implicated in motivational goal-directed social behavior.

138 nomenon showing how animals can update their motivational goals without any new learning or condition

139 accumbens core (NAc) is known to mediate the motivational impact of reward-predictive cues, but littl

140 retrieval propranolol degrades the emotional/motivational impact of the CS, required for sign-trackin

141 t erase memories, but blunts their emotional/motivational impact.

142 Curiously, fatigue and motivational impairment evolve rapidly, suggesting acute

143 nic inflammation, ultimately contributing to motivational impairments in psychiatric and other medica

144 of effort exertion and consequent rescue of motivational impairments.

145 mice, as a novel pharmacological target for motivational impairments.

146 r of neurological conditions associated with motivational impairments.

147 hese disorders have little or no effect upon motivational impairments.

148 re obtained, and withdrawal can be seen as a motivational incentive because due to allostatic referen

149 formulation contextualizes the complementary motivational incentives for reward-related stimuli and e

150 al reinforcers and serves as a substrate for motivational information processing.

151 role of sharing agency in socioaffective and motivational information processing.

152 tary and cingulate motor area) was linked to motivational, intentional and timing properties, the BP'

153 Overall, these findings demonstrate that a motivational intervention with parents can have importan

154 owed by a tailored telephone-delivered brief motivational interview (intervention) versus an attentio

155 the effectiveness of a program consisting of motivational interviewing (MI) and feedback of urine cot

156 ns with a glaucoma coach who had training in motivational interviewing (MI), and (3) 5 phone calls wi

157 larly cognitive-behavioural therapy but also motivational interviewing and Gamblers Anonymous, are su

158 Motivational interviewing as a component of an individua

159 and Referral to Treatment (SBIRT), including motivational interviewing counseling and referral out fo

160 lifestyle modification program that included motivational interviewing delivered by an experienced nu

161 onse to the in-person glaucoma education and motivational interviewing intervention used in conjuncti

162 Findings have been used to adapt a motivational interviewing intervention, which is being e

163 f care coordination with case management and motivational interviewing techniques over 6 months.

164 ompetent, youth-friendly care, and intensive motivational interviewing training.

165 a 30-min structured conversation informed by motivational interviewing with a forward focus to preven

166 Outcomes were variable, although motivational interviewing, which involves individuals in

167 ing eye drop instillation techniques using a motivational interviewing-based approach.

168 at hospital discharge to receive either (1) motivational interviewing-based health coaching plus a w

169 Training in and implementation of a motivational interviewing-informed brief intervention pr

170 The same reward can possess different motivational meaning depending upon its magnitude relati

171 formation about recent rewards to adjust the motivational meaning of a CS.

172 istory to support the flexible assignment of motivational meaning to sensory cues.

173 iological mechanisms mediating assignment of motivational meaning, we recorded the activity of neuron

174 Here we describe the motivational mechanism by which the forebrain thirst cir

175 Incentive hope refers to a specific motivational mechanism in the brain - considered only in

176 All participants received motivational messaging and support from study staff to m

177 eased as mice became sated, showing a strong motivational modulation of licking bout initiation and t

178 While motivational neural circuits facilitate learning based o

179 -solving behaviour could have been caused by motivational or nutritional differences between our trea

180 s combined with clinical elements, including motivational or readiness to change strategies, subseque

181 d striatum play important roles in affective-motivational pain processing and reward learning.

182 al perspectives within cognitive, emotional, motivational, personality, interpersonal, and group psyc

183 it is unclear how this population influences motivational processes and cue processing.

184 istic and foraging-like tasks can help parse motivational processes that bridge learning and foraging

185 hether this reflects prolonged modulation of motivational processes underpinning fatigue or separate

186 onship of attentional, cognitive control and motivational processes with DNA methylation patterns of

187 d expectation and contingency drive distinct motivational processes, and can be dissociated by manipu

188 Dopamine is integral to attentional and motivational processes, but studies are largely restrict

189 been implicated in a number of cognitive and motivational processes, but understanding how individual

190 are known to influence neural and behavioral motivational processes-might underlie some of these chan

191 are often attributed to biased cognitive or motivational processes.

192 ic dopamine system is strongly implicated in motivational processes.

193 d that this subset has an inhibitory role in motivational processes.

194 lness, including homeostatic, circadian, and motivational processes.

195 , indicating a selective effect on incentive motivational processes.

196 edly been linked to associative learning and motivational processes.

197 basal amygdala to aversive outcome-dependent motivational processes.SIGNIFICANCE STATEMENT The specif

198 Cues associated with reward can acquire motivational properties (i.e., incentive salience) that

199 Cues predicting rewards can gain motivational properties and initiate reward-seeking beha

200 hRs in the habenula-IPn circuit regulate the motivational properties of nicotine.

201 suggest that fundamental differences in the motivational properties of psychostimulant drugs between

202 e is, however, considerable variation in the motivational properties of such stimuli, both as a funct

203 n conjunction with empirical research on the motivational psychology of parental care.

204 es might represent enhanced communicative or motivational purposes.

205 ily available, overeating is often driven by motivational, rather than metabolic, needs.

206 sitive Potentials (LPPs, a robust measure of motivational relevance) than neutral images in both grou

207 wo central subsets of stimulation sites with motivational relevance.

208 D(1) receptor signaling and does not reduce motivational responding.

209 Motivational responses are mediated in part by NAc AMPA

210 deprivation narrows and focuses the brain's motivational responses to the deprived target.

211 cleus accumbens (NAc) mediates cue-triggered motivational responses, and activations in the NAc trigg

212 sed the hedonic experience and music-related motivational responses, risperidone led to a reduction o

213 a key brain region regulating emotional and motivational responses, we observed a decrease in the ra

214 egnancy plays a critical, and likely causal, motivational role in reducing alcohol use disorder risk

215 These results help to disambiguate the motivational role of prodopaminergic medications: they a

216 tify predominantly sensory-attentional (N1), motivational salience (feedback-related negativities [FR

217 tomically positioned as an interface between motivational salience and behavioral output.

218 delay period, after which it came to reflect motivational salience as movement onset neared.

219 arly in movement planning, before reflecting motivational salience as movement onset neared.

220 cular whether it reflects expected value and motivational salience at different latencies.

221 sing the possibility that expected value and motivational salience manifest at different latencies du

222 tica and smaller increases in the LPP as the motivational salience of pleasant images increased (exci

223 ad larger increases in LPP amplitudes as the motivational salience of pleasant images increased.

224 drawal signals from the body potentiates the motivational salience of reward cues through the recruit

225 his attentional competition is influenced by motivational salience of sounds is, however, not well-un

226 projections to the NAc do not influence the motivational salience of the cue.

227 at beta activity reflects expected value and motivational salience on different time scales during re

228 axons may provide a reinforcement signal of motivational salience that invigorates adaptive behavior

229 sant" categories and ignore the variation of motivational salience within these categories.

230 m disorders display abnormalities related to motivational salience, or the ability of stimuli to elic

231 nt-related potential components sensitive to motivational salience-the Early Posterior Negativity (EP

232 tal regions reflects both expected value and motivational salience.

233 on appears to be important in attribution of motivational salience.

234 ntexts, consistent with a role in increasing motivational salience.

235 agnetic resonance imaging to examine whether motivational-salient cues could exert a differential imp

236 native analysis of inhibitory control toward motivational-salient cues.

237 the content of awake replay events following motivational shifts between hunger and thirst.

238 ons for the processing of reward-related and motivational signals in the basal ganglia.

239 olimbic circuits regulate the attribution of motivational significance to incentive cues that predict

240 f the constellation of negative emotional or motivational signs and symptoms of withdrawal from drugs

241 re surgery and reliably produces somatic and motivational signs of dependence.

242 the presence of food and the second encodes motivational state acting as a gain controller for adapt

243 , the level of dopamine activity encodes the motivational state and controls to what extent payoffs a

244 o tilt the functional output of NAc toward a motivational state favoring drug seeking and relapse.

245 of Neuron, Burgess et al. (2016) explore how motivational state interacts with visual processing, by

246 ngth of the unconditioned stimuli and on the motivational state of the animals.

247 These findings reflect the motivational state required to learn, and show accelerat

248 sing, depending on the animal's affective or motivational state.

249 Sleep profoundly affects the emotional and motivational state.

250 ide mode of population activity that encoded motivational state.

251 e characterized by an acute reorientation of motivational state; pleasurable activities are avoided,

252 ulates brain regions important for divergent motivational states and cognition.

253 t the availability of food rewards influence motivational states and elicit food-seeking behaviors.

254 -target interactions and potency to discrete motivational states during a single self-administration

255 rd the preferred goal and suggest a role for motivational states in determining replay content.

256 ical aversive stimuli, as well as "opponent" motivational states induced by removal of sustained rewa

257 animals maintain and switch between distinct motivational states is an important question in neurosci

258 Motivational states modulate how animals value sensory s

259 The motivational states of thirst and hunger are represented

260 Thus, motivational states specify initial conditions that dete

261 racted to such cues and these cues can evoke motivational states that instigate and maintain drug-see

262 ces is integrated with information about its motivational states to guide affective and behavioral re

263 cholinergic neurons integrate cognitive and motivational states with behavior.

264 connected with other regulators of aversive motivational states, including the lateral habenula (LHb

265 encoding reward-related features, value and motivational states.

266 by subcortical circuits that drive specific motivational states.

267 ted in several cocaine-induced emotional and motivational states.

268 dial prefrontal cortex and the generation of motivational states.

269 these neurons would be a key node regulating motivational status.

270 nula (LHb) neurons are activated by negative motivational stimuli and play key roles in the pathophys

271 ough which they signal positive and negative motivational stimuli is incompletely understood.

272 /inhibition patterns after negative/positive motivational stimuli, similar to the RMTg, while tempora

273 that neither alcohol intake history nor the motivational strength of alcohol predicted the propensit

274 sion and other disorders show effort-related motivational symptoms, such as anergia, psychomotor reta

275 ch tasks could be useful as animal models of motivational symptoms.

276 for understanding ketamine-induced shifts in motivational symptoms.

277 ynamics of the internal goals that drive our motivational system and how can this system be sufficien

278 l of bodily disturbance belonging to a basic motivational system that urges the individual to act and

279 ocus of our attention, but how cognitive and motivational systems influence sensory cortex is not wel

280 individuals over evolutionary time, and our motivational systems may have been naturally selected to

281 We explore how three motivational systems-compassion, self-interest, and envy

282 ch enables activity in motor, cognitive, and motivational systems.

283 n feeding behavior in light of psychological motivational theory and highlights the importance of mid

284 egulation are discussed, with a focus on the motivational theory of life-span development.

285 behaviors, from their monomorphic appetitive/motivational to their dimorphic consummatory phases.

286 However, the core function of pain is motivational-to direct both short- and long-term behavio

287 ive behaviors in the wild as well, but their motivational underpinnings are unclear.

288 l area (VTA) may contribute to the increased motivational valence of drug-associated cues triggering

289 D2 MSNs, which encode positive and negative motivational valences, respectively.

290 This behavioural bias was related to motivational value and reflected in the updating of brai

291 ficult to parse the predictive vs. emotional/motivational value of CSs in non-human animals, but stud

292 tions, both the value of salt itself and the motivational value of its predictive cues.

293 n all rats, but is attributed with emotional/motivational value to a greater extent in some rats (sig

294 ues, with some individuals attaching greater motivational value to cues than others.

295 gic system is involved in the attribution of motivational value to reward predictive cues as well as

296 ual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker

297 ions oppositely encode positive and negative motivational value, are differentially modulated by anim

298 investigated how social cues gain incentive-motivational value.

299 common currency of information theoretic and motivational variables are discussed.SIGNIFICANCE STATEM

300 opamine levels covaried with reward rate and motivational vigor.