ライフサイエンスコーパス: motor

1 thetic A-philic, GC rich sequences by the T4 motor.

2 catalysts without direct interference by the motor.

3 Motor abundance occurs when the ratio of GEV to NGEV exc

4 naptic anterograde tracing, we show that the motor-action-related topographical organization of the s

5 ronal population representations of targeted motor actions on single trials, we developed an optical

6 a detailed understanding of contribution of motor actions to sensing is needed to understand even se

7 activation is essential for the execution of motor actions; however, the molecular mechanisms that gi

8 oth condensin I and II exhibit ATP-dependent motor activity and promote extensive and reversible comp

9 stimulation of mouse brain and modulation of motor activity in vivo.

10 Motor activity of nuclear myosin was dependent on the Hs

11 search should shift focus on sleep, physical/motor activity, or circadian patterns to identify common

12 in microtubules, cytoskeleton linkages, and motor activity.

13 reviously revealed that syntabulin acts as a motor adapter linking kinesin-1 motor and presynaptic ca

14 The regulated assembly and disassembly of motor-adaptor complexes ensures that cargoes are loaded

15 es in the maximum power output per myosin-1C motor and 4-fold changes in the velocity and the resisti

16 statin-1, which improved cellular as well as motor and cognitive behavior outcomes at 1 DPI in the AP

17 fMRI) data that assess observed longitudinal motor and cognitive change rates from the multisite Trac

18 ns at 6 mo postpartum with infant growth and motor and cognitive development.

19 d HMOs are associated with infant growth and motor and cognitive development.

20 o elicit a remarkable variety of perceptual, motor and cognitive effects, but the functional-anatomic

21 in areas remote to the infarct that mediated motor and cognitive recovery.

22 Reintroduction of Myo9b or Myo9b motor and GAP mutants revealed that local GAP activity r

23 Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine s

24 in acts as a motor adapter linking kinesin-1 motor and presynaptic cargos.

25 possible differential effects on the primary motor and sensory cortices by using transcranial magneti

26 NDH, WAIS-IIIDS, Stroop Color-Naming; better motor and SIP summary T scores.

27 grade traffic of IFT and accumulation of IFT motors and complexes in the proximal region of cilia.

28 mbly, the attachement-detachment dynamics of motors and that of crosslinking proteins.

29 principles of a number of types of molecular motors and their interactions with their tracks.

30 requires exquisite coordination of sensory, motor, and cognitive processes.

31 amples were removed from prefrontal, primary motor, and primary visual cortices and investigated with

32 e the result of local integration of visual, motor, and spatial information.

33 Molecular motors are at the heart of cellular machinery, and they

34 l time-keeping activity in the supplementary motor area (SMA), orchestrated and sequenced by activity

35 sin activity and the dynamics of microtubule/motor assemblies in vitro as well as in diverse intracel

36 ty within the sensory-motor, lateral sensory-motor, auditory, salience, and subcortical networks in p

37 ochondrial motility in zebrafish sensory and motor axons.

38 These data suggest a broad regulation of motor behavior by DA neurons within multiple hypothalami

39 nsation and perception are intertwined, with motor behavior serving as a scaffold to shape the sensor

40 erebellar output neurons in association with motor behavior.

41 discovered that sleep-wake brain states and motor behaviors are coregulated by shared neurons in the

42 Neuronal circuits that control motor behaviors orchestrate multiple tasks, including th

43 al and functional links between auditory and motor brain regions.

44 hanical work produced by arrays of molecular motors can be used to induce a macroscopic effect.

45 pheral nervous system for normal sensory and motor capabilities, analogous approaches to peripheral n

46 tic connectivity and function in the sensory-motor circuit to improve the SMA motor phenotype.SIGNIFI

47 The brains of young songbirds develop motor circuits that achieve the goal of imitating a spec

48 reduced neuronal activity in spinal sensory-motor circuits.

49 pses might separate hygrosensory inputs from motor circuits.

50 ts of disrupting this process on sensory and motor circuits.SIGNIFICANCE STATEMENT Disrupted mitochon

51 rimotor processing, and executive control of motor commands in dystonia pathophysiology.

52 the hypothesis that the transformation from motor commands to force trajectories by syringeal muscle

53 modulated to allow execution of supraspinal motor commands, it may be deficient in freezers during A

54 ally characterize the roles of PT and aMF in motor compensation by relating diffusion-tensor-imaging-

55 ement for the transition to active packaging motor complex.

56 has explored the effects of manipulations in motor complexity.

57 ingly, increased loads, similar to increased motor concentrations, also exponentially decreased the m

58 The motor consists of a series of stator units surrounding a

59 ies [1] where it functions in cognition [2], motor control [3], and sensory processing [4].

60 severed axons is fundamental to reestablish motor control after spinal-cord injury (SCI).

61 STATEMENT The cerebellum plays a key role in motor control and motor learning.

62 eta bursts in sensorimotor cortex in healthy motor control better than sham feedback.

63 Our results show that motor control can be an active component of sensory lear

64 tivity, and roles in sensory acquisition and motor control in a light-weight model organism.

65 Our results show that motor control is an active component of sensory learning

66 Researching the sensory corollaries of motor control thus can be crucial to understand sensory

67 model that ultimately links descending vocal motor control to tissue vibration and sound requires emb

68 Brain dopamine is critical for normal motor control, as evidenced by its importance in Parkins

69 n red nucleus (RN), a brain region linked to motor control, as male and female rats performed a novel

70 ite widespread diversity in behavior and its motor control, we know little about the evolution of cor

71 for investigating neural mechanisms of limb motor control.

72 ins [3], provoking the question of how these motors coordinate their action to ensure smooth and fast

73 clei neurons targeted.SIGNIFICANCE STATEMENT Motor coordination and skilled movements are driven by t

74 )-tetrahydrocannabinol-induced impairment of motor coordination in mice.

75 on of specific neuronal networks involved in motor coordination, emotions, and cognition.

76 nscranial magnetic stimulation (TMS) of hand motor cortex (M1) as a model, but in this model it is di

77 ed that antidromic activation of the primary motor cortex (M1) plays a significant role in mediating

78 interactions between premotor ventral (PMv)-motor cortex (M1), anterior inferior parietal lobule (aI

79 st measured after stimulation of the primary motor cortex (M1), corticospinal tract (CST), and reticu

80 In the primary motor cortex (M1), residual subperceptual hand touch sig

81 ns of large groups of neurons in the primary motor cortex (M1).

82 ted predominately in the white matter of the motor cortex and the spinal cord.

83 excitable phase of beta oscillations in the motor cortex are known to lead to muscle responses of gr

84 sitive cells were observed in postmortem ALS motor cortex as compared with controls, and these cells

85 5-25 Hz) scalp EEG signals recorded over the motor cortex during a pre-movement preparatory phase wer

86 to integrate physiological accounts of this motor cortex microcircuit with the pathophysiology of ne

87 TMS was delivered to the motor cortex of healthy human subjects, and baseline MEP

88 n over the arm representation of the primary motor cortex, maximal voluntary contractions, the StartR

89 re than 1,300 neurons in adult mouse primary motor cortex, providing a morpho-electric annotation of

90 gle pulse TMS was administered over the left motor cortex, using anatomical scans of each subject to

91 ) over the caudal forelimb area (CFA) of the motor cortex.

92 rts are intermixed and interrelated in human motor cortical areas at single-neuron resolution.

93 To this end, this work investigates how motor cortical neural activity changes when three human

94 tle is known about cholinergic influences on motor cortical regions.

95 gth structure of PfMyoA in two states of its motor cycle.

96 ly by engendering noisier sensory input into motor decision processes eliciting reactive behaviour.

97 hat interactions with others can alter human motor decision strategies and that competition with a ri

98 a risk-averse opponent is key for optimizing motor decision-making.

99 mplexity of acute impairments, of which limb motor deficit, dysphagia, and incontinence have declined

100 ected patients (Foxp2(+/R552H) mice) display motor deficits and impaired synaptic plasticity in the s

101 of astrocytes relevant to the development of motor deficits in mice.

102 allidus (GPe) are critically involved in the motor deficits of dopamine-depleted mouse models of Park

103 y prevent neurodegeneration and accompanying motor deficits.

104 icant loss of dopamine neurons, resulting in motor deficits.

105 t associations between retinal thickness and motor deterioration.

106 analyses suggested that LNS benefited gross motor development among boys more than did CSB (interact

107 L rings is to seal the outer membrane after motor disassembly.

108 mice facilitates PD pathologies and elicits motor disorders associated with augmentation of delta-se

109 ng model, in which kinesin-5 tails stabilize motor domains in the microtubule-bound state by slowing

110 Myosin II is the main force-generating motor during muscle contraction.

111 Many viruses employ ATP-powered motors during assembly to translocate DNA into procapsid

112 Complex motor dysfunction remains common in HIV and is associate

113 Our data suggest that cannabinoid-related motor effects are associated with unbalanced direct/indi

114 nt is symptomatic, focused on improvement in motor (eg, tremor, rigidity, bradykinesia) and nonmotor

115 Comprehensive control of each motor element in this numerically simple system paves th

116 cortical silent period, and amplitude of the motor evoked potentials conditioned by cortico-cortical

117 To test this hypothesis, we examined motor-evoked potentials (MEPs) elicited by transcranial

118 On each day, motor-evoked potentials in upper limb muscles were first

119 an essential role in sensory perception and motor execution.

120 ocus on changes in brain activity related to motor execution.

121 While now a well-recognised non-motor feature of treated PD, much remains unknown about

122 sula features of early dystonia, early tonic motor features, and sensorimotor aura.

123 s of light-driven third-generation molecular motors featuring various structural modifications at the

124 Cytoplasmic dynein is the primary motor for microtubule minus-end-directed transport and i

125 Biological molecular motors (or biomolecular motors for short) are nature's solution to the efficient

126 We show that stochastic motor force not only enhances diffusion but also leads t

127 ynaptic links with cognitive, affective, and motor forebrain circuits.

128 for socioemotional behavior, cognitive, and motor function (e.g. amygdala, hippocampus, cerebellum).

129 ble to repair spinal cord tissue and restore motor function after complete spinal cord transection ow

130 5-HT2C receptors in the effects of SSRIs on motor function and affective behavior, highlighting the

131 ntrol levels and significantly improves both motor function and neuronal viability.

132 structure to measures of proximal and distal motor function in patients after hemispherotomy.

133 d no reproducible abnormalities in survival, motor function, or neurodegeneration.

134 nce of injury, without associated changes in motor function.

135 have sex-specific deficits in body mass and motor function.

136 w interpretation of cerebellar structure and motor function.

137 logy of neurodegenerative diseases affecting motor functions.

138 ce displayed only subtle impairment in their motor functions.

139 Proton flow through the F(o) motor generates rotation of the central stalk, inducing

140 ngly simple behaviors.SIGNIFICANCE STATEMENT Motor-guided sensation and perception are intertwined, w

141 Engineering with biomolecular motors has the potential to yield commercially viable de

142 Decades after the motor homunculus was first proposed, it is still unknown

143 anterograde motor kinesin-II, the retrograde motor IFT dynein, and the IFT-A and -B complexes.

144 hanisms underlying alcohol-related cognitive/motor impairment and inform interventions for addiction.

145 Motor impairment, assessed by ad hoc clinical scales, wa

146 a sub-toxic dose of MPTP resulted in severe motor impairment, selective loss of dopamine neurons and

147 ehavioral deficits, including intestinal and motor impairments.

148 red to healthy controls, we assessed waiting motor impulsivity using a behavioral task, as well as st

149 osin binding protein-C, the "C-zone." Myosin motors in domains further from the filament midpoint are

150 to force development, only about 10% of the motors in each filament bear the peak force, and these a

151 g hypotheses, we examined different types of motor inhibition in a group of 19 patients with primary

152 aneously demultiplexed from ongoing efferent motor intention, enabling intracortically controlled clo

153 The bacterial flagellar motor is the most complex structure in the bacterial cel

154 (IFT) machinery consists of the anterograde motor kinesin-II, the retrograde motor IFT dynein, and t

155 actin filaments, together with a microtubule motor, kinesin-1, and an actin motor, myosin-V, are esse

156 d functional connectivity within the sensory-motor, lateral sensory-motor, auditory, salience, and su

157 e brain regions and exhibit sensorimotor and motor learning deficiencies.

158 the force is ideally suited to investigating motor learning during tool use.

159 First, we asked if well-known features of motor learning in lab-based experiments generalize to a

160 to physiological plasticity and to distinct motor learning tasks, which suggests they represent sepa

161 Here we asked whether, in the context of motor learning where errors decrease across trials, peop

162 bellum plays a key role in motor control and motor learning.

163 it strategies in favor of low-level implicit motor learning.

164 We compared different motor-learning tasks, i.e. model-free vs. model-based le

165 lga C. reinhardtii, on average, 10 kinesin-2 motors "line up" in a tight assembly on the trains [3],

166 adius) that we quantified in relation to the motor map.

167 le, kinesin can switch from a fast detaching motor (median attachment duration <0.2 s) to a persisten

168 This occurs because the motor memory acquired through learning comprises represe

169 ed during sleep, significantly improved fine motor movements of the limb corresponding to the sensori

170 rt an unexpected role for the atypical actin motor Myo6 in creating primary branch structure by speci

171 with two gene families, the actin-dependent motor, myosin XI (a,b), and the putative chitin receptor

172 a microtubule motor, kinesin-1, and an actin motor, myosin-V, are essential for osk mRNA posterior lo

173 bility of these toxins to target and bind to motor nerve terminals is a key factor determining their

174 , fronto-parietal network (FPN), and sensory-motor network (SMN)] function and operate.

175 onds and explore transient configurations of motor network connectivity in acute stroke.

176 terhemispheric connectivity between cortical motor networks independent of individual deficit severit

177 The precise pattern of motor neuron (MN) activation is essential for the execut

178 ropathologically relevant sites, such as the motor neuron and the growth cone.

179 euromuscular diseases, such as regression of motor neuron axons, motor neuron death, and muscle degra

180 s, such as regression of motor neuron axons, motor neuron death, and muscle degradation and atrophy c

181 ive disease, characterized by synaptic loss, motor neuron death, and reduced neuronal activity in spi

182 e the disease process resulting in selective motor neuron degeneration in different disease variants

183 In addition to cerebellar ataxia, motor neuron disease is often seen in SCA2, and ATXN2 CA

184 modulation will help slow the progression of motor neuron disease, offering a novel treatment paradig

185 a, Alzheimer's disease, Parkinson's disease, motor neuron diseases, or epilepsy.

186 urons resulting from a premature switch from motor neuron to OPC production.

187 These data suggest that Prdm8 regulates the motor neuron-OPC switch by controlling the level of Shh

188 Corticospinal motor neurons (CSMN) and callosal projection neurons (CP

189 eroxide dismutase-1 (mutSOD1) kill wild-type motor neurons (MNs) by an unknown mechanism.

190 ive survival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons

191 induced pluripotent stem cell (iPSC)-derived motor neurons and astrocytes to model early cell type-sp

192 apse that is the point of connection between motor neurons and skeletal muscle.

193 neuroprotective to seeded aggregation within motor neurons by reducing (mislocalized) cytoplasmic TDP

194 We find that leg motor neurons exhibit a coordinated gradient of anatomic

195 ption factors control the diversification of motor neurons into distinct neuronal subsets by ensuring

196 demonstrates at single-neuron resolution how motor neurons may help shape threat-reward choice behavi

197 evealed that prdm8 mutant embryos have fewer motor neurons resulting from a premature switch from mot

198 he disease derives solely from dysfunctional motor neurons that may be efficiently targeted by restri

199 How pMN progenitors switch from producing motor neurons to OPCs with distinct fates is poorly unde

200 DP43 transcripts were enriched in vulnerable motor neurons, and we observed a striking accumulation o

201 neuromuscular junction (NMJ), the output of motor neurons, but its impact on NMJ repair remains unkn

202 very proboscis muscle through control of its motor neurons, the first such collection for an appendag

203 aling between sensory neurons and non-target motor neurons.

204 imic different acquired or genetic causes of motor neuropathies, it is a diagnosis not to be missed s

205 hereditary paediatric condition associating motor neuropathy (MN) and deafness.

206 A long-standing challenge in motor neuroscience is to understand the relationship bet

207 he middle of the movement and a reduction in motor noise near the target.

208 ella, yet, less is known about the packaging motor of Pseudomonas-phages that have increasing biomedi

209 The genome packaging motor of tailed bacteriophages and herpesviruses is a po

210 lts, blood pressure, demographic, cognitive, motor, olfactory and affective information enabling the

211 nsity of the cytoskeletal filaments on which motors operate.

212 Biological molecular motors (or biomolecular motors for short) are nature's s

213 Kinesin-5 motors organize mitotic spindles by sliding apart microt

214 ive high signal intensity)-for prediction of motor outcomes in very preterm infants.

215 tegrate cognitive control signals to reshape motor outcomes reactively within trials and proactivity

216 Worse motor outcomes were associated with longer dystonia dura

217 pathway might encounter failure of effective motor output and give rise to freezing of gait as clinic

218 Volitional inhibition of motor output could be increased to prevent the tic from

219 in the cerebellum is essential for refining motor output, and the first stage of this processing occ

220 ic alpha2-Na/K ATPase that triggers episodic motor paralysis in mice.

221 ions with respect to the ongoing respiratory motor pattern of inspiration (I), post-inspiration (PI)

222 We studied the driver's neural and motor patterns while he drove a sports car on the "Top G

223 s through neurofeedback training can improve motor performance in healthy subjects.

224 Initially, JQ1 enhanced motor performance in NT mice.

225 muscular junction abnormalities, compromised motor performance, and premature death.

226 rol groups, except for a minor difference in motor performance.

227 osome is an essential and divergent Myosin A motor (PfMyoA), a first order drug target against malari

228 the sensory-motor circuit to improve the SMA motor phenotype.SIGNIFICANCE STATEMENT Spinal muscular a

229 H and null mutant mice using behavioural and motor phenotyping alongside molecular modelling and anal

230 role of the cerebellum and its importance in motor planning.

231 s greatly differ from those within uninjured motor pools.

232 sleep-deprivation condition, preinspiratory motor potential amplitude, electrical activity of the di

233 alesional M1 within gamma frequencies during motor preparation for hand opening.

234 linguistic as well as visual, auditory, and motor processes.

235 l neural nodes engaged in both cognitive and motor processing.

236 Here, we examine how the distinct motor programs of the nematode C. elegans are coupled to

237 ccelerated degradation of KIF1A, a kinesin-3 motor promoting the sorting and transport of PRV virions

238 that were defined based on their sensory and motor properties, providing insight into the mechanisms

239 tion to stereocilia tips is dependent on the motor protein MYO15A and its cargo EPS8.

240 ally and functionally interacts with the DNA motor protein RAD54.

241 Kinesin is part of the microtubule-binding motor protein superfamily, which serves important roles

242 Perturbations of microtubules and motor proteins disrupt this sequence of events.

243 Motor proteins from the kinesin-8 family depolymerize mi

244 filament sliding is driven by the action of motor proteins.

245 CI often show various degrees of spontaneous motor recovery of hindlimb/leg function.

246 l. reveals how a dedicated laryngeal sensory motor reflex circuit protects our airways from aspirated

247 atients, who are often undergoing concurrent motor rehabilitation.

248 his cue-specific activity was independent of motor-related activity and thus tracked specifically the

249 e related to learning or reinforcing sensory-motor relations in the sensory population.

250 reviously imagined, and, in particular, that motor representations may underpin automatic false-belie

251 entrations, also exponentially decreased the motors' residence time at the microtubule end.

252 e investigated in 35 humans (23 females) how motor resonance is altered when the observer's weight ex

253 Our results highlight that motor resonance is not robustly driven by object weight

254 (MSO) and increasing in steps of 2% until a motor response with a 50 uV peak to peak amplitude, defi

255 timulation to a highly cooperative flagellar motor response.

256 teromers mediating maladaptive molecular and motor responses in the dopamine-denervated striatum may

257 ssion or inhibition of errant or maladaptive motor responses, often called cognitive control.

258 tial signals into representations that guide motor responses.

259 tial signals into representations that guide motor responses.SIGNIFICANCE STATEMENT In our natural en

260 with the N-tier ring in front and the C-tier motor ring behind.

261 45, Mcm2-7, GINS) helicase contains a Mcm2-7 motor ring, with the N-tier ring in front and the C-tier

262 ion to develop, by trial-and-error, the same motor routine whose execution resulted in the precise ti

263 e change in the total Hammersmith Functional Motor Scale Expanded (HFMSE) score, assessed at months 6

264 II assessed using the Hammersmith Functional Motor Scale Expanded (HFMSE).

265 ume was independently associated with MABC-2 motor scores at 4.5 years (beta = -0.095, 95% confidence

266 ntrolled, and reversible conduction block in motor, sensory, and autonomic nerves, but causes transie

267 ose of the GABA(B) agonist baclofen impaired motor sequence learning and visuomotor learning in 20 yo

268 rall, our study provides evidence that human motor sequence learning occurs outside of M1.

269 C receptor antagonists for both reduction of motor side effects of SSRIs and augmentation of therapeu

270 he basis by which sustained running benefits motor skill learning, presenting a target for clinical t

271 g blocks the beneficial effect of running on motor skill learning.

272 arousal state of the brain covaries with the motor state of the animal.

273 neous recovery and control conditions, while motor strength remained unchanged.

274 The response regulator CheY increased motor switching from counterclockwise (CCW) to clockwise

275 However, the initial motor symptoms are usually very subtle and, as a result,

276 ortical somatostatin interneurons alleviates motor symptoms in a parkinsonian mouse model.

277 s the functional organization of the fly leg motor system and establishes Drosophila as a tractable s

278 Emerging evidence indicates that the motor system may participate in decision-making but the

279 These findings signal that our motor system may underpin more of social cognition than

280 nto the neurocomputational properties of the motor system, we propose that beat anticipation relies o

281 Experiments aiming to understand sensory-motor systems, cognition and behavior necessitate traini

282 (NIf) at the interface between auditory and motor systems.

283 Thus, BH sites are important determinants of motor targeting and may have a similar role in the local

284 opontine neurons strongly encode sensory and motor task information and are selectively necessary for

285 e human volunteers, using two matched visual-motor tasks that stressed either response speed or visua

286 inducing conformational changes in the F(1) motor that catalyzes ATP production.

287 Cytoplasmic dynein is an AAA(+) motor that drives the transport of many intracellular ca

288 attachment duration <0.2 s) to a persistent motor that sustains attachment (median attachment durati

289 We show that, although myosin motors throughout the filament contribute to force devel

290 ctrical charge displacement required for the motor to overcome the viscous cochlear load.

291 re affordable but generally rely on a single motor to perform simple operations and thus do not fully

292 r, which connects the dimerizing tail of the motor to the AAA+ ring.

293 rotein assemblies that function as molecular motors to couple the energy of nucleoside triphosphate b

294 been used to re-engineer existing molecular motors to have, for instance, altered speed, processivit

295 Cellular function requires molecular motors to transport cargoes to their correct intracellul

296 MglA directs molecular motors to transport the bacterial actin homolog MreB and

297 and interval-based timing by addressing how motor training develops accurate spatiotemporal patterns

298 fatigue development are thought to restrict motor unit activation and limit exercise tolerance.

299 The age-related trajectory of motor unit discharge characteristic differs according to

300 system, or stems from broader defects of the motor unit, arguing for systemic SMN repletion.