ライフサイエンスコーパス: mouse

1 ed in mutant mRNA decay, as in zebrafish and mouse.

2 s growth in vitro, in macrophages and in the mouse.

3 lso found in single cell RNA-seq analysis in mouse.

4 e capacity in a conditional FIH-1 transgenic mouse.

5 pe information of human scRNA-seq data, with mouse.

6 ves than PPI networks for both zebrafish and mouse.

7 l mouse models of AD, including the J20-hAPP mouse.

8 otocol(12,13), during preimplantation in the mouse.

9 er trachea mesenchymal identity in human and mouse.

10 eurons in the MOB.SIGNIFICANCE STATEMENT The mouse accessory olfactory system (AOS) interprets social

11 bulb (AOB), the first neural circuit in the mouse accessory olfactory system, is critical for interp

12 In summary, the mouse-adapted SARS-CoV-2 MA model demonstrates age-relat

13 Mouse-adaptive mutations in the RV-A16 2C protein allowe

14 The mouse alkaline ceramidase 2 gene (Acer2) is highly expre

15 The ODInCas9 mouse allows robust and tunable genome editing granting

16 to detect native A(2A)R-D(2)R heteromers in mouse and human brain.

17 erstood, and were proposed to differ between mouse and human cells.

18 t can suppress progression and metastasis of mouse and human cutaneous squamous cell carcinoma.

19 This system also operates in mouse and human embryos, where EPHA receptors are enrich

20 , we developed organoid systems from primary mouse and human induced pluripotent stem cell-derived lu

21 spiratory syncytial virus (RSV) infection in mouse and human lung is associated with oxidative injury

22 Here we show that primary mouse and human T cells engage in macropinocytosis that

23 the Il9 locus to allow BATF binding in both mouse and human Th9 cultures.

24 generated a Kif11 conditional knockout (CKO) mouse and investigated the consequences of early postnat

25 tivation induces apoptosis in JAK2-dependent mouse and primary human cells, causing regression of the

26 toms, ex vivo biological tissue, and in vivo mouse and rat models of cancer with a thermal camera rev

27 tomography sequencing on zebrafish, chicken, mouse, and human embryos.

28 omplexes at the plasma membrane of human and mouse arterial myocytes.

29 ther knockdown of Disc1 (Disc1-KD) in mature mouse astrocytes of the prefrontal cortex (PFC) or the h

30 A higher hairy and enhancer of split 1:mouse atonal homolog 1 ratio in ilea from Msi1-overexpre

31 ted scratching and inflammatory responses in mouse atopic dermatitis models.

32 peated tones pyramidal (Pyr) neurons in male mouse auditory cortex (A1) exhibit facilitating and stab

33 re is renewed interest in the anatomy of the mouse autonomic nervous system.

34 ive bacterial species in different wild-type mouse backgrounds as well as in knockout, transgenic, an

35 malian cells in culture and lethality during mouse bacteremia.

36 In comparison to a single mouse bed, the cost and time associated with each scan w

37 PBG hyperplasia in vivo in the DDC-mediated mouse biliary injury model.

38 Is, we examined adaptive immune responses in mouse bladders.

39 iversity and gene expression dynamics in the mouse blood and ischemic heart at the single-cell level,

40 fies modular components of three-dimensional mouse body language called 'syllables'.

41 res in primary human foreskin fibroblasts or mouse bone marrow-derived dendritic cells infected with

42 In mouse bone marrow-derived macrophages, heme induced HO-1

43 D, the virus remained active within the SCID mouse brain and showed widespread infection of normal br

44 esults: (18)F-FAC accumulates in the healthy mouse brain at levels similar to (18)F-FAC in the blood

45 We discuss benefits of mapping a mouse brain at the level of synapses.

46 ween the mood disorders, particularly in the mouse brain cell types implicated by the expression patt

47 sed in postmitotic projection neurons during mouse brain development.

48 rmined that parenchymal PrPSc plaques of the mouse brain preferentially incorporated underglycosylate

49 Upon passive staining of mouse brain, lung or intestinal tissue surface with minu

50 o locate sterols in tissue slices (10 um) of mouse brain.

51 lly manipulate cells in the neonatal rat and mouse brain.

52 on, and improve synaptic dysfunction in 3xTg mouse brain.

53 MEIS, TFs which are broadly expressed across mouse branchial arches, and HOXA2, which is expressed in

54 immunity against tumor cells in vitro and in mouse cancer models.

55 nt mouse xenograft models and four human and mouse cell lines we examined in vitro cisplatin/JH-RE-06

56 Using genetically manipulated human and mouse cells, and ex vivo and in vivo rat models, we unco

57 of GABAergic neurons activated by GA in the mouse central amygdala (CeA(GA) neurons).

58 features in positive-/negative-ion mode from mouse cerebellum tissue.

59 We showed that mouse cholangiocytes in the channel of the device became

60 The strong conserved synteny between mouse chromosome 12aF1 and human chromosome 14q32 has en

61 region of fission yeast DNA inserted into a mouse chromosome was previously observed to adopt a mito

62 ree of functional compensation in the ageing mouse cochlea.

63 multiple MYO7A isoforms are expressed in the mouse cochlea.

64 reducing the number of Lgr5(+) stem cells in mouse colonic organoids.

65 uman-induced pluripotent stem cells into the mouse cortex.

66 Here, we discuss genetic models of mouse DC development and function that have aided in cor

67 The adult K/BxN transgenic mouse develops spontaneous autoimmune arthritis with joi

68 We first report the crystal structure of mouse DHX36 bound to ADP.

69 ganisation distinct from that of surrounding mouse DNA.

70 Although disease progression in the mouse does not perfectly model the human disease, it sha

71 gh the layers and structures of ex vivo nude mouse ear skin and extracted pharmacokinetic parameters

72 ell RNA sequencing data from tissue-specific mouse ECs generated by the Tabula Muris consortium.

73 nd integrin alpha5 proteins in K41 wild-type mouse embryo fibroblasts (MEFs), CRT null MEFs were unre

74 Using genetic deletion in mouse embryo fibroblasts and a combination of CRISPR-med

75 oliferation, redox state and migration using mouse embryonic fibroblast Balb/3T3, human dermal fibrob

76 f proteomes extracted from Escherichia coli, mouse embryonic fibroblast cell cultures, and Arabidopsi

77 lted in immortalization of Rb1 (-/-) primary mouse embryonic fibroblasts and in aggressive tumor grow

78 Mouse embryonic stem cells (mESCs) cultured with MEK/ERK

79 elomere maintenance and genomic stability of mouse embryonic stem cells.

80 iac differentiation, whereas Hoxb1-deficient mouse embryos display premature cardiac differentiation.

81 tly and indirectly by RFX1, RFX2 and RFX3 in mouse ependymal cells.

82 tial and temporal resolution through in vivo mouse erythroid differentiation.

83 four key TFs contribute to cis-regulation in mouse ESCs, we assayed two massively parallel reporter a

84 We analyze data from both preclinical mouse experiments and a clinical trial of FMT to validat

85 Here, we used a mouse expressing a truncated dominant negative form of t

86 ain and acute brain slices from the knock-in mouse expressing epitope-tagged DAT.

87 accessibility of chromatin in the developing mouse fetus.

88 te the two noise components of 3975 genes in mouse fibroblast cells.

89 h-TfR1-ECD) followed by in vivo selection in mouse for brain parenchyma penetrating antibodies.

90 Mature mouse frataxin (78-207) only contributes 7-15% to the to

91 n various biological contexts (e.g., cancer, mouse genetics, yeast genetics).

92 A murine Chlamydia readily spreads from the mouse genital tract to the gastrointestinal tract while

93 r part of human chromosome 21 or orthologous mouse genomic regions, are providing valuable insights i

94 and measures of contractile function in the mouse heart.

95 ells were highly susceptible to a murine CoV-mouse hepatitis virus.

96 m will not only help delineating the role of mouse higher areas for visual processing, but also shed

97 Using a molecular replacement approach in mouse hippocampal neurons, we show here that tamalin pla

98 utophagy, and alphaKlotho, we used the BK/BK mouse (homozygous for mutant Becn1(F121A) ) with increas

99 Methods: For physiologic evaluation of the mouse hotel, temperature and anesthesia were tested for

100 e report proteomic coverage of young and old mouse HSCs and progenitors, with broader implications fo

101 As in the mouse, human A-MYB drives transcription of both pachyten

102 ctions are generally restricted by human and mouse IFITM1, IFITM2, and IFITM3, using gain- and loss-o

103 attern of labeling among the human, rat, and mouse in these brain regions as well as between the diff

104 pan-brain-specific conditional knockout (KO) mouse incapable of FAO due to the loss of carnitine palm

105 scription start sites of downstream genes in mouse, including 117 protein-coding genes and 144 lincRN

106 t biotin biosynthesis inhibitors in standard mouse infection models.

107 cer-associated PRD mutation R3008H (R3016 in mouse) into mice.

108 Here, using multiphoton live cell imaging in mouse kidney tissue, FIB-SEM, and other complementary te

109 autophagic flux, and alphaKlotho-hypomorphic mouse (kl/kl) with impaired urinary Pi excretion, low au

110 Thus, the new mouse line is an ideal tool to study cytotoxic T lymphoc

111 hanism, we created a controllable transgenic mouse line that sustains cortical MET signaling.

112 Using a novel transgenic mouse line to model the impact of human APP (hAPP)/Abeta

113 We have a mouse line with Tropomyosin receptor kinase B (TrkB) rec

114 With the use of a transgenic mouse line, optical clearing, and imaging techniques, co

115 Using an MrgprC11(CreERT2) transgenic mouse line, we labeled a small subset of itch-sensing ne

116 Using a Grp-Cre knock-in mouse line, we show that the upper epidermis of the skin

117 Here, we employed Gdf5-LacZ reporter mouse lines to assess the spatiotemporal activity of Gdf

118 Analysis of reporter mouse lines TRPV1(PLAP-nlacZ) and TRPV1-Cre:tdTomato com

119 An N-Lip C-Lip fusion of mouse lipin-2 is catalytically active, which suggests ma

120 ibility of perturbing protein synthesis in a mouse liver by targeting translation elongation factor 2

121 des in clinical specimens, cell lysates, and mouse liver tissue samples, demonstrating its highly sen

122 and confirmed in subcutaneous and orthotopic mouse lung cancer models.

123 Primary mouse lung endothelial cells (MLEC) and human umbilical

124 Mouse lung pericytes were isolated and transfected with

125 increase in CTC attachment to ECs or Balb/C mouse lungs, respectively, compared to untreated conditi

126 ted through both PCR and immunostaining that mouse lymphatic muscle cells expressed Ca(v)3.1 and Ca(v

127 that, although T-type VGCCs are expressed in mouse lymphatic smooth muscle, they do not play a signif

128 in supporting adhesion of cultured human and mouse macrophages in experiments using recombinant TSP4

129 del for the induction of these structures in mouse macrophages undergoing IL-4-mediated fusion.

130 autophagy genes increased the sensitivity of mouse mammary carcinoma cells to radiation therapy in vi

131 In human breast cancer cell lines and 4T1 mouse mammary tumor cells, PD-L1 expression was regulate

132 ated plasma membrane targeting of the B-type mouse mammary tumor virus (MMTV) and C-type HIV-1, which

133 Yeast and mouse mimics of the most common variant, P286R, produce

134 ons were replicated in the Q175 Htt knock-in mouse model (p = 6.0 x 10(-8)) and in the transgenic she

135 Preclinical studies using an in vivo mouse model also demonstrated that combining Enz plus ol

136 matoid arthritis FDA-approved drug) in a CDI mouse model and establish an adequate dosage for treatme

137 In in vivo studies using a syngeneic mouse model bearing orthotopically injected 4T1 cells, C

138 scriptional profiling in an adult-onset Pkd2 mouse model before cysts formed revealed significant dif

139 aphy fractioned protein samples from 3xTg-AD mouse model brain homogenates.

140 We utilized a mouse model carrying a knockout of the mitochondrial fus

141 Using this mouse model denoted knock-in alpha2 (KI alpha2), our ele

142 Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of med

143 ity in PDAC progression, we generated a PDAC mouse model in which CAF plasticity is modulated by gene

144 Here, we describe a mouse model intended to reproduce hereditary PPGL throug

145 diet can rescue synaptic plasticity in this mouse model of AD (P = 0.007 to untreated APP/PS1).

146 1 T MRI scanner using a transgenic APP/PSEN1 mouse model of Alzheimer's disease.

147 abnormalities and mTORC1 hyperactivity in a mouse model of Birt-Hogg-Dube syndrome.

148 ped method was demonstrated in an orthotopic mouse model of breast cancer.

149 ons and after deletion of Pdcd10 (Ccm3) in a mouse model of CCM.

150 issue of the JCI, Auguste et al. generate a mouse model of DCM in which they delete Lmna in cardiomy

151 ve undergone chronic social defeat stress, a mouse model of depression, at both the level of synaptic

152 the chronic unpredictable mild stress (CUMS) mouse model of depression.

153 ovement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human

154 vestigated the role of PAG1 in a preclinical mouse model of house dust mite (HDM)-induced allergic se

155 is effective at lowering bacterial load in a mouse model of infection.

156 insights into the requirement for Runx1 in a mouse model of inv(16) acute myeloid leukemia (AML).

157 mors in a highly aggressive, immunocompetent mouse model of lung adenocarcinoma improves long-term su

158 rain barrier dysfunction, and mortality in a mouse model of malaria.

159 Here, we used a mouse model of maternal obesity to investigate the impor

160 lex, a major downstream target of RAC1, in a mouse model of melanoma driven by BRAF(V600E);PTEN loss.

161 ding ceramides, are selectively reduced in a mouse model of obesity.

162 r agonistic autoantibody (AT(1) -AA)-induced mouse model of PE.

163 In a mouse model of persistent lymphocytic choriomeningitis v

164 To address this gap, we adapted an infant mouse model of pneumococcal colonization and transmissio

165 GDH inhibition were studied in the bleomycin mouse model of pulmonary fibrosis.

166 We addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H m

167 n the meningeal lymphatics are depleted in a mouse model of SAH, the degree of erythrocyte aggregatio

168 ial for the formation of primary cilia, in a mouse model of SCLC induced by conditional deletion of b

169 lergen-induced Th2 inflammation and AHR in a mouse model of severe steroid resistant asthma, potentia

170 nflammasome was confirmed in an experimental mouse model of stroke.

171 re to Delta9-tetrahydrocannabinol (THC) in a mouse model of surgically-induced endometriosis.

172 we assessed their therapeutic activity in a mouse model of T cell-mediated autoimmunity that mimics

173 etic humanized NOD-scidIL2Rgamma(null) (NSG) mouse model of T-cell-mediated human islet allograft rej

174 islet-infiltrating B lymphocytes in the NOD mouse model of T1D produce Abs directed against the neur

175 Using the well-established mouse model of TB, our new data provide evidence that th

176 te low-avidity autoreactive cells in the NOD mouse model of type 1 diabetes.

177 Herein, we generated a mouse model that allow for activation of NF-kappaB speci

178 In this study, we use a reporter mouse model to permanently "time stamp" NK cells and typ

179 190A is a tumor suppressor using a xenograft mouse model with carcinoma cells harboring defined ARHGA

180 a-Gal(null) is the first available humanized mouse model with such features.

181 Using a mouse model with two reporter genes, we observed that, w

182 an be successfully examined in the humanized mouse model, and experimentally validate the predicted f

183 tion was critical for AD progression in this mouse model, and that disease progression could be ameli

184 In the MMTV-Delta16HER2 transgenic mouse model, oncogene transformation resulted in a timel

185 cessibility, ameliorated light damage in our mouse model, supporting a causal link between decreased

186 y established mammary specific Tet2 deletion mouse model, the data reveals that TET2 plays a pivotal

187 In this study, using a knockout mouse model, we show that the transcription factor hypox

188 RC01-N using a highly reproducible humanized mouse model.

189 vicovaginal HPV16 pseudovirus infection in a mouse model.

190 limited tumor growth in a tumor implantation mouse model.

191 he hepatic conditional beta-catenin knockout mouse model.

192 d spleen and is lethal in a hemolytic anemia mouse model.

193 tes SCLC progression in an Rb1/Trp53-deleted mouse model.

194 t tumour suppressor in a SHH medulloblastoma mouse model.

195 rain homogenates from an Alzheimer's disease mouse model.

196 nscriptional cofactor HOPX is upregulated in mouse models and in human YAP1-fusion induced ependymoma

197 some cognitive and behavioral outcomes in DS mouse models and in humans with Ts21.

198 With the development of knockout mouse models and molecular inhibitors unique to necropto

199 r, wild-type mice and all existing humanized mouse models cannot be used to test the efficacy of vacc

200 atient-derived xenografts (PDX) are tumor-in-mouse models for cancer.

201 However, genetic evidence in mouse models for prostate cancer to support the crucial

202 diverse NUP98-fusion proteins, we developed mouse models for regulatable expression of NUP98/NSD1, N

203 A major problem with such mouse models is that bnAb expression often hinders B cel

204 n impaired neurovascular function in several mouse models of AD, including the J20-hAPP mouse.

205 orable in vivo biodistribution properties in mouse models of CAIX-positive clear cell renal cell carc

206 ufficient to induce phenotypes identified in mouse models of cancer cachexia, including muscle fiber

207 -PD1 therapy in suppressing tumour growth in mouse models of cancer.

208 Current mouse models of CCHFV infection reliably succumb to viru

209 Mouse models of cervical cancer were used to evaluate th

210 Mouse models of DS, involving trisomy of all or part of

211 duces enteric nervous system regeneration in mouse models of HSCR.

212 In vivo, m-RCT was evaluated in mouse models of hypercholesterolemia that were naturally

213 es and circulating tumor cells (CTCs) in two mouse models of mammary cancer: genetically modified MMT

214 Two mouse models of polymerase exonuclease deficiency shed l

215 In mouse models of SS, inhibition of BMP6 signaling reduced

216 tify similarities between human diseases and mouse models produced by the International Mouse Phenoty

217 e an overview of the studies in experimental mouse models that try to address this question.

218 uman chromosome 14q32 has enabled the use of mouse models to elucidate imprinting mechanisms and deci

219 We utilized knockin and transgenic mouse models to evaluate the structural, functional and

220 Here, we use multiple mouse models to investigate in vivo consequences.

221 We used multiple mouse models to investigate the mechanisms of NMJ reinne

222 Using type 1 diabetic (T1DM) mouse models together with cultured Schwann cells (SCs)

223 The established HCC mouse models were characterized at histopathological, im

224 ostasis, we generated genetically engineered mouse models where we can conditionally delete Stk11 and

225 iew progress and challenges in the use of AD mouse models, highlight emerging scientific innovations

226 o patient samples and genetically engineered mouse models, we developed organoid systems from primary

227 SG7 slows tumor growth in multiple syngeneic mouse models.

228 ntry and spread and is protective in vivo in mouse models.

229 ocesses at the molecular level in convenient mouse models.

230 e does not appear to benefit SRS patients or mouse models.

231 cer patient data, cell lines, and orthotopic mouse models.

232 ardial infarction (MI)-induced heart failure mouse models.

233 cells in immunodeficient and immunocompetent mouse models.

234 mes, which promotes tumorigenesis in various mouse models.

235 ies, miRs predicted to bind to the 3'-UTR of mouse MR were profiled by qRT-PCR after aldosterone stim

236 ble for insulin-stimulated glucose uptake in mouse muscle.

237 Here we employ a series of mouse mutants with constitutive and conditional Sox10 de

238 ghlight the functional features of human and mouse NaCTs and provide a plausible molecular basis for

239 on of daughter neuroblasts in the developing mouse neocortex.

240 a Mediator complex subunit protein, Med23 in mouse neural crest cells (Med23(fx/fx);Wnt1-Cre), result

241 k clusters, termed RDCs, in cultured primary mouse neural stem and progenitor cells (NSPCs).

242 usion of the positively charged A1 insert in mouse neuroligin-1 increases its binding to heparan sulp

243 Primary mouse neurons transfected with CYLDM719V exhibited incre

244 otoxicity in Drosophila and cultured primary mouse neurons.

245 We propose that mouse nighttime sleep, analogous to the human siesta, is

246 l imaging in a rat self-administration and a mouse noncontingent model, to investigate whether change

247 Primordial follicle assembly in the mouse occurs during perinatal ages and largely determine

248 n and functional screening using an in vitro mouse oocyte development system, we identified eight tra

249 es normal growth-to-maturation transition in mouse oocytes by sculpting the transcriptome to degrade

250 dataset consisting of ~2 million developing mouse organ cells, we show Hopper's even representation

251 Using an HD mouse striatal cell model and HD mouse organotypic brain slices we found that D(1)R-induc

252 The protocol takes 5 d to process 384 mouse organs from collecting tissues to obtaining raw se

253 al and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide asso

254 PEAMOtecan as monotherapy for efficacy in a mouse orthotopic glioma model.

255 ess this gap, here we developed a transgenic mouse overexpressing Sulf2 in hepatocytes under the cont

256 t that males lacking piRNAs from a conserved mouse pachytene piRNA locus on chromosome 6 (pi6) produc

257 squamous trans-differentiation of human and mouse pancreatic cancer cells can influence the phenotyp

258 d mouse models produced by the International Mouse Phenotyping Consortium.

259 quencing of more than 1,300 neurons in adult mouse primary motor cortex, providing a morpho-electric

260 rmed using tissue sections from a whole-body mouse pup.

261 The mouse, rat, and human brain flatmap vector graphics file

262 In vivo mouse reconstitution assays resealed that only CD69(High

263 ectroscopic (XAS) fingerprinting and in vivo mouse relative bioavailability (RBA) measurements for a

264 of the Wallerian degeneration slow (Wld(S)) mouse, research has generated extensive knowledge of the

265 rvival from 27 to 70 days in a GBM xenograft mouse resection model with no sign of tumour recurrence.

266 We have approached this problem in mouse retina by analysing the kinetic differences betwee

267 Knockout of Yap1 in the adult mouse RPE caused cell depolarization and tight junction

268 phabeta(+), double-negative (DN) T cells, in mouse secondary lymphoid organs.

269 of cyclic genes that are associated with the mouse segmentation clock, suggesting that this oscillato

270 yl sulfonates (PFSAs) were enriched in dosed mouse serum, suggesting in vivo transformation of sulfon

271 sis of tryptophan degradation metabolites in mouse serum.

272 To this end, mouse skin infection models allow researchers to examine

273 h neurotrophic AAV-PHP.B vector carrying the mouse Slc25a46 coding sequence.

274 ivity after serum incubation was assessed in mouse slices using molecular markers and electrophysiolo

275 es and 144 lincRNA genes, 93.7% of which are mouse-specific.

276 We demonstrate that GBF1 is present in mouse spinal cord and muscle tissues and is particularly

277 The development of immunodeficient mouse strains with high-level engraftment of normal and

278 h the level of hearing loss in the different mouse strains, being most severe for C57BL/6NTac and C57

279 on exposure to electronic cigarettes, across mouse strains, sex and ages.

280 ges in gene expression in the livers of both mouse strains.

281 c, and other types of genetically engineered mouse strains.

282 Using an HD mouse striatal cell model and HD mouse organotypic brain

283 collectors from two different regions of the mouse, studied ex vivo.

284 reduced phosphorylation of SMAD1/5/8 in the mouse submandibular glands, and led to a recovery of SG

285 d and wild-type NSCs isolated from the adult mouse subventricular zone niche.

286 ler cells, slowed tumor growth, and improved mouse survival.

287 iated chemotaxis of monocytes in a syngeneic mouse T-cell lymphoma in skin.

288 Under mild conditions, full-length (fl) mouse TIA1 spontaneously oligomerizes to form a metastab

289 AS3MT expression in mouse tissues closely modeled that of human and differed

290 15% to the total frataxin protein present in mouse tissues.

291 ed STING-noninteracting mutants of human and mouse TRIFs.

292 plasmic and little proliferation occurred in mouse utricles.

293 ory and VIP inhibitory cells in layer 2/3 of mouse visual cortex were impacted by visual experience i

294 erbB1,2,3,4 in PV and excitatory neurons in mouse visual cortex.

295 lbumin-expressing (PV) inhibitory neurons in mouse visual cortex.

296 how binocular disparity is processed in the mouse visual system will not only help delineating the r

297 Using a Notch reporter mouse, we discovered FCSCs localized within the TMJ supe

298 nd diverse viral populations throughout each mouse within the first day postinfection, but by 48 h th

299 Our results show that the hACE2 mouse would be a valuable tool for testing potential vac

300 report that, unexpectedly, in two different mouse xenograft models and four human and mouse cell lin