ライフサイエンスコーパス: mucociliary

1 g valuable opportunities for the analysis of mucociliary activity in relation to bacteria recruitment

2 o pneumococcal colonization by impairing the mucociliary activity of the airway mucosa, reducing the

3 ells achieved terminal differentiation, with mucociliary activity strongly selecting for full gliding

4 f the ostiomeatal complex, playing a role in mucociliary activity.

5 human bronchial epithelium (NHBE) exhibiting mucociliary activity.

6 ell as planar cultures composed of polarized mucociliary airway epithelial cells, we detect genotype-

7 hed in vitro model of human pseudostratified mucociliary airway epithelium (HAE).

8 hed in vitro model of human pseudostratified mucociliary airway epithelium (HAE).

9 were investigated in a fully differentiated, mucociliary airway epithelium model.

10 Reduced mucociliary allergen clearance exacerbated Stat6-depende

11 Furthermore, using theoretical indices of mucociliary and cough clearance, we identified that M. a

12 aging agents is reduced by the action of the mucociliary apparatus and by formation of a physical bar

13 The data support a model in which the mucociliary apparatus impairs colonization yet cilia pro

14 Intact mucociliary barrier function and early airway neutrophil

15 rway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying mic

16 pertension (in Liddle syndrome) and impaired mucociliary clearance (in cystic fibrosis).

17 es within the airway surface liquid regulate mucociliary clearance (MCC) activities, the primary inna

18 ondrial iron loading, showed impaired airway mucociliary clearance (MCC) and higher pulmonary inflamm

19 the conditional deletion of Gas2l2 impaired mucociliary clearance (MCC) and led to mucus accumulatio

20 Mucociliary clearance (MCC) assays in CF ferrets further

21 drial dysfunction, airspace enlargement, and mucociliary clearance (MCC) disruption during CS exposur

22 AC6 inhibitor were protected from CS-induced mucociliary clearance (MCC) disruption.

23 tides are among the most potent mediators of mucociliary clearance (MCC) in human lungs.

24 Mucociliary clearance (MCC) in subjects with CB was nega

25 Mucociliary clearance (MCC) is a critical host innate de

26 Mucociliary clearance (MCC) is a major airway host defen

27 Mucociliary clearance (MCC) is the primary physical airw

28 The efficiency of the mucociliary clearance (MCC) process that removes noxious

29 us barrier traps and eliminates them through mucociliary clearance (MCC).

30 port to adjust ASL volume to maintain proper mucociliary clearance (MCC).

31 Significant improvements in mucociliary clearance (P < 0.001), gastrointestinal pH (

32 cells promotes purinergic receptor-regulated mucociliary clearance activities necessary for innate lu

33 Management strategies, including augmenting mucociliary clearance and aggressively treating infectio

34 lammatory cell recruitment, mucus secretion, mucociliary clearance and airway surface liquid composit

35 nsport, producing dehydrated mucus, impaired mucociliary clearance and an opportune environment for c

36 nnate immune activity has been attributed to mucociliary clearance and antimicrobial polypeptides of

37 impairs key host defense mechanisms, such as mucociliary clearance and bacterial killing in CF airway

38 fibrosis (CF) is characterized by defective mucociliary clearance and chronic airway infection by a

39 rategies have evolved in the airways such as mucociliary clearance and cough.

40 t NO production, resulting in stimulation of mucociliary clearance and direct antibacterial effects.

41 nasal residence time but also minimizing the mucociliary clearance and enzymatic degradation.

42 l and nasopharyngeal gland deficits, reduced mucociliary clearance and impaired auditory tube gating

43 o clinical consequences on respiratory-tract mucociliary clearance and lung function, fertility, and

44 include loss of lysozyme secretion, reduced mucociliary clearance and overgrowth of nasal commensal

45 ds secrete copious mucus strands to increase mucociliary clearance and protect the lung.

46 ier in the airway in order to overcome rapid mucociliary clearance and reach the underlying epitheliu

47 ftor/ivacaftor, improve airway hydration and mucociliary clearance and reduce pathogen CF acquisition

48 cerebrospinal fluid flow, sensory reception, mucociliary clearance and renal physiology indicate that

49 p uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behav

50 opment of fetal and neonatal lung, affecting mucociliary clearance and Th1 responses.

51 tion accompanies ciliary motion defects, but mucociliary clearance and vectorial infection spread res

52 On the other hand, mucociliary clearance appeared to play a less prominent

53 enefit have been inconclusive and effects on mucociliary clearance are unknown.

54 nefit have been inconclusive, and effects on mucociliary clearance are unknown.

55 tion and suggests therapeutic improvement of mucociliary clearance as a novel treatment strategy for

56 These data show that mucociliary clearance associated with mild chronic bronc

57 Defective mucociliary clearance associated with the absence of the

58 particular, epithelial mucins facilitate the mucociliary clearance by physically trapping inhaled mic

59 particular, epithelial mucins facilitate the mucociliary clearance by physically trapping the inhaled

60 The rates of mucociliary clearance by pretreatment with amiloride and

61 Impaired mucociliary clearance contributes to the pathophysiology

62 However, shorter drug retention time and mucociliary clearance curtail the efficiency of the intr

63 PCD-associated phenotypes of hydrocephalus, mucociliary clearance defects in the upper airway, and a

64 onic obstructive pulmonary disease and other mucociliary clearance defects.

65 Effective mucociliary clearance depends on adequate airway hydrati

66 Later in infection, mucociliary clearance deteriorates.

67 an Multicilin that cause a severe congenital mucociliary clearance disorder due to reduced generation

68 on of multiple motile cilia (RGMC) is a rare mucociliary clearance disorder.

69 lial cell dysfunction, cilia shortening, and mucociliary clearance disruption.

70 ed UTP and amiloride in combination improved mucociliary clearance from the peripheral airways of the

71 However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after in

72 volume of airway surface liquid, we measured mucociliary clearance in 16 normal subjects after inhala

73 ar ATP and its metabolite adenosine regulate mucociliary clearance in airway epithelia.

74 Mucociliary clearance in conducting airways, reduction o

75 ed airway surface liquid volume and impaired mucociliary clearance in cystic fibrosis, FOXI1-KO and F

76 ne signaling molecules led to an increase in mucociliary clearance in explanted tracheae that was Trp

77 r agonist, is effective at acutely enhancing mucociliary clearance in healthy, nonsmoking adults.

78 The impaired mucociliary clearance in individuals with Cystic Fibrosi

79 Mucociliary clearance in mammalian respiratory airways d

80 let cell metaplasia and diminishes efficient mucociliary clearance in mice with AAD, resulting in inc

81 There is no evidence for a primary defect in mucociliary clearance in most patients with CRS.

82 iquid are associated with increased rates of mucociliary clearance in normal subjects.

83 he rheology of airway secretions and enhance mucociliary clearance in patients with CF.

84 se) reduces airflow obstruction and improves mucociliary clearance in patients with cystic fibrosis (

85 Dysfunction of motile cilia can impair mucociliary clearance in the airway and result in primar

86 (CFTR), which regulates anion transport and mucociliary clearance in the airways.

87 experience demonstrates that restoration of mucociliary clearance in the lungs after transplantation

88 If mucociliary clearance in the respiratory epithelium is s

89 ted information on its actions on the airway mucociliary clearance in vivo.

90 Mucociliary clearance is composed of three components (i

91 Mucociliary clearance is determined by ciliary activity

92 Mucociliary clearance is one of the major lines of defen

93 Mucociliary clearance is one of the major lines of defen

94 icate that the antigen-induced impairment of mucociliary clearance is partly dependent on increased e

95 In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inf

96 ient subgroup of RA suggests that diminished mucociliary clearance may underlie repeated asthma exace

97 nearly sterile lower respiratory tract when mucociliary clearance mechanisms are functioning effecti

98 ects of inhaled vehicle and UTP/amiloride on mucociliary clearance of [99mTc] iron oxide particles fr

99 Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens.

100 a chloride channel that is essential for the mucociliary clearance of respiratory pathogens in humans

101 me, effects that would be proposed to reduce mucociliary clearance of respiratory pathogens.

102 structural attributes that provide effective mucociliary clearance of the lower airspace, the airway

103 Mucociliary clearance of whole and peripheral lung was i

104 cycle in the propagation of purine-mediated mucociliary clearance on human airway epithelial surface

105 Defects in components of mucociliary clearance or barrier integrity are associate

106 ollowing inhalation of 99mTc aerosol, or for mucociliary clearance or the rate of clearance of the ra

107 mately 1.4% per minute) approached the rapid mucociliary clearance rates (approximately 2.0% per minu

108 Pretreatment with amiloride increased mucociliary clearance rates (approximately twofold) afte

109 Subsequently, mucociliary clearance rates were measured by gamma scint

110 mbrane nucleotide-release coordinates airway mucociliary clearance responses (mucin and salt, water s

111 ed culture consists of various cell types, a mucociliary clearance system, and tight junctions, repre

112 tion; excessive mucus secretion and impaired mucociliary clearance that leads to airflow obstruction

113 Mucin 5B (MUC5B) has an essential role in mucociliary clearance that protects the pulmonary airway

114 nts exhibited mucus obstruction and abnormal mucociliary clearance that resemble the airway defects a

115 from human airway epithelial cells regulates mucociliary clearance through cell surface nucleotide re

116 ist, isoproterenol synergistically increased mucociliary clearance velocity (MCCV) in ferret tracheas

117 Mucociliary clearance was measured using gamma scintigra

118 A 2.5-fold increase in mucociliary clearance was seen in response to UTP alone

119 Mucociliary clearance was slowed 4 hours postchallenge i

120 onstriction is associated with impairment of mucociliary clearance with a time course that is consist

121 rosolized UTP +/- amiloride clearly enhances mucociliary clearance without acute adverse effects in n

122 To test the hypothesis that mucociliary clearance would increase after inhalation of

123 mucus clearance (tracheal mucus velocity and mucociliary clearance), inhaled ETX001 was able to accel

124 t on mucociliary function (cilia beating nor mucociliary clearance).

125 Recently, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthm

126 the well-described physical barrier and the mucociliary clearance, a variety of systems, including t

127 It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal ep

128 vironment, diminished cough reflex, impaired mucociliary clearance, altered alveolar macrophage funct

129 ne regulates epithelial functions supporting mucociliary clearance, an important airway defense mecha

130 lytic treatment loosens mucus mesh, enhances mucociliary clearance, and abolishes airway hyperreactiv

131 echanisms of airway surface fluid secretion, mucociliary clearance, and adequate immune response to e

132 ability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting

133 CFTR) protein function on airway physiology, mucociliary clearance, and establishment of Pseudomonas

134 mechanisms including antimicrobial peptides, mucociliary clearance, and phagocytic cells.

135 ration, causing mucus dehydration, decreased mucociliary clearance, and recurrent acute bacterial inf

136 of LABA/LAMA combinations on hyperinflation, mucociliary clearance, and symptom severity may all cont

137 on, excessive mucus production with impaired mucociliary clearance, and symptom severity.

138 d the structure of motile cilia and impaired mucociliary clearance, barrier function, and epithelial

139 easured tracheal mucus velocity, a marker of mucociliary clearance, before and for 8 hours after anti

140 Substudies evaluated mucociliary clearance, beta-adrenergic sweat secretion r

141 characterized by abnormal ion transport and mucociliary clearance, but TGF-beta1 is also associated

142 eating machines that play a critical role in mucociliary clearance, cerebrospinal fluid movement, and

143 ay mucus to mediate the critical function of mucociliary clearance, cleansing the airways of inhaled

144 Mucociliary clearance, driven by the engine of ciliary b

145 stal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas

146 Inhaled hypertonic saline enhances mucociliary clearance, improves lung function, and reduc

147 nce and tracheal mucus velocity, a marker of mucociliary clearance, in allergic and nonallergic sheep

148 n tracheal mucus velocity (TMV), a marker of mucociliary clearance, in sheep and (2) if the ET-1-indu

149 We find that inhalation of dry air impairs mucociliary clearance, innate antiviral defense, and tis

150 motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the

151 cal airway dilation associated with impaired mucociliary clearance, may occur sporadically or as a co

152 Rimantadine had no effect on nasal patency, mucociliary clearance, nasal signs, or on symptoms and s

153 tion of Splunc1 in mouse airways affects the mucociliary clearance, resulting in decreased innate imm

154 ss mucin production, however, overwhelms the mucociliary clearance, resulting in defective mucosal de

155 Mucociliary clearance, the physiological process by whic

156 an inherited disorder that leads to impaired mucociliary clearance, to repeated chest infections, and

157 acheal mucus velocity, an in vivo measure of mucociliary clearance, was also reduced by e-cig vapor.

158 across the lung mucosal barrier, as well as mucociliary clearance.

159 respiratory dysfunction caused by defective mucociliary clearance.

160 disorders that are characterized by impaired mucociliary clearance.

161 tional motility that is essential for proper mucociliary clearance.

162 ated with altered mucus rheology and reduced mucociliary clearance.

163 tributes to CF lung disease by impairment of mucociliary clearance.

164 n of bronchial lymphoid tissue and decreased mucociliary clearance.

165 Thus, gliding may be necessary to overcome mucociliary clearance.

166 tory agents, and new approaches that improve mucociliary clearance.

167 logical changes consistent with insufficient mucociliary clearance.

168 ysical forces such as coughing, sneezing and mucociliary clearance.

169 retory epithelial cells that are involved in mucociliary clearance.

170 ce liquid (ASL) volume and the efficiency of mucociliary clearance.

171 ciliary structure and function and impaired mucociliary clearance.

172 Nase reduces airflow obstruction or improves mucociliary clearance.

173 he main epithelial functions involved in the mucociliary clearance.

174 , cytotoxicity, cilia beating frequency, and mucociliary clearance.

175 cellular composition and loss of coordinated mucociliary clearance.

176 r understand disease-specific impairments in mucociliary clearance.

177 minished transepithelial anion secretion and mucociliary clearance.

178 onal ciliated epithelium to allow for normal mucociliary clearance.

179 y respond to defects in ciliary motility and mucociliary clearance.

180 causing reduced antimicrobial properties and mucociliary clearance.

181 d function of motile cilia causes failure of mucociliary clearance.

182 Pb in the stomach within 4 h, presumably via mucociliary clearance.

183 as well as airway surface liquid volume and mucociliary clearance.

184 e production to increase ciliary beating and mucociliary clearance.

185 B48 and HCoV-OC43, altered cilia beating and mucociliary clearance.

186 s ciliary beat frequency (CBF) and speeds up mucociliary clearance.

187 es with improved airway hydration status and mucociliary clearance.

188 defects in ciliogenesis and complete loss of mucociliary clearance.

189 x1) channels to release ATP, which regulates mucociliary clearance.

190 tentiation on epithelial fluid secretion and mucociliary clearance.Methods: The effects of a novel lo

191 itor that protects this key component of the mucociliary defense system was also uncovered.

192 of CFTR, an ion channel required for airway mucociliary defense.

193 In 16HBE14o- and primary mucociliary differentiated human bronchial epithelial ce

194 of squamous NHTBE cells compared with normal mucociliary differentiated NHTBE cells.

195 In both 16HBE14o- and primary mucociliary-differentiated cells, preincubation with H.

196 ocesses, and pathways were identified during mucociliary differentiation of both CRSwNP and control-N

197 in mediating early biological effects in the mucociliary differentiation of bronchial epithelia.

198 transcriptome-wide analysis during in vitro mucociliary differentiation of human adult BSCs from CRS

199 nsight into the molecular basis of sinonasal mucociliary differentiation, demonstrating that transcri

200 reduced potential in cell proliferation and mucociliary differentiation.

201 that the suppression is conserved following mucociliary differentiation.

202 UP variations can cause mucociliary drainage and ventilation problems, causing c

203 Our data support a role of mucociliary dysfunction and aberrant epithelial pro-fibr

204 could prevent and/or reverse antigen-induced mucociliary dysfunction in allergic sheep.

205 Therefore, we propose that TGF-beta1-induced mucociliary dysfunction in CF airways is associated with

206 of Duox2, representing a novel mechanism for mucociliary dysfunction in inflammatory airway diseases.

207 ired in CF, thereby possibly contributing to mucociliary dysfunction in this disease, at least during

208 that inhalation of e-cig vapor causes airway mucociliary dysfunction in vitro and in vivo.

209 sis and primary ciliary dyskinesia, in which mucociliary dysfunction predisposes subjects to high rat

210 disease, airway inflammation with associated mucociliary dysfunction remains largely unaddressed.

211 onchospastic actions, can also contribute to mucociliary dysfunction, a central component of the path

212 ely reversed CF- and inflammation-associated mucociliary dysfunction, independent of its angiotensin

213 ways, may be a source of agents for treating mucociliary dysfunction.

214 hibitors may be useful in protecting against mucociliary dysfunction.

215 tes to the acute (0 to 6-hr) antigen-induced mucociliary dysfunction.

216 Airway inflammation causes mucociliary dysfunction.

217 ep model of CF-like, inflammation-associated mucociliary dysfunction.Measurements and Main Results: N

218 Mucociliary epithelia are essential for homeostasis of m

219 our understanding of pathological changes in mucociliary epithelia that accompany diseases such as as

220 the development and function of mucosal and mucociliary epithelia.

221 the nasal and conducting airway to a mature mucociliary epithelial cell layer at ALI using a medium

222 Here, we use an in vivo model of vertebrate mucociliary epithelial development to show that Dishevel

223 odel system for in vivo molecular studies of mucociliary epithelial development.

224 pithelial cells undergo differentiation into mucociliary epithelium in vitro, and its overexpression

225 sal cells differentiating into organoids and mucociliary epithelium in vitro.

226 erate a well-differentiated pseudostratified mucociliary epithelium to investigate whether RSV infect

227 r-liquid interface culture into an organized mucociliary epithelium with transepithelial resistance.

228 Although they formed a mucociliary epithelium, ciliary function tended to decli

229 with lung cancer and expressed primarily in mucociliary epithelium.

230 erning and in shorter multicilia in external mucociliary epithelium.

231 nd an 80% decrease in HRV-C infection of the mucociliary epithelium.

232 Motile cilia are essential components of the mucociliary escalator and are central to respiratory-tra

233 sical removal of viruses and bacteria on the mucociliary escalator is an important aspect of the mamm

234 lticiliated and secretory cells sustains the mucociliary escalator required for clearance of microbes

235 te [UTP]) activate several components of the mucociliary escalator, suggesting they may have potentia

236 ed to overcoming the clearance action of the mucociliary escalator.

237 Mucociliary flow is an important defense mechanism in th

238 ings), ASL height (confocal microscopy), and mucociliary function (by tracking the surface flow of ap

239 l epithelium ex vivo, AS-NS had no impact on mucociliary function (cilia beating nor mucociliary clea

240 neic tracheal autografts demonstrated normal mucociliary function after transplantation, allogeneic r

241 f nicotine-containing e-cig vapors on airway mucociliary function in differentiated human bronchial e

242 aining only PG/VG on airway inflammation and mucociliary function in primary human bronchial epitheli

243 ease with age, we investigated correlates of mucociliary function in subjects with PNTM infections an

244 e-dependent K(+) (BK) channels, critical for mucociliary function in the absence of CFTR (CF transmem

245 hey suggest that the main nicotine effect on mucociliary function is mediated by TRPA1 and not nicoti

246 effectiveness to rescue BK activity and thus mucociliary function was tested in vitro using primary,

247 Tracheal mucous velocity CTMV), an index of mucociliary function, was measured with a roentgenograph

248 polarization, independent of acquisition of mucociliary function.

249 in conducting airways for the maintenance of mucociliary function.

250 logeneic recipients failed to achieve normal mucociliary function.

251 helial cell morphology, gene expression, and mucociliary function.

252 effects, while HPMC-NS caused inhibition of mucociliary function.

253 l surface fluid levels, airway hydration and mucociliary function.

254 spiratory pathogens secrete toxins to impair mucociliary immunity, we examined the effects of acute e

255 y five V. fischeri cells aggregate along the mucociliary membranes of a superficial epithelium prior

256 We show that mucociliary membranes of animal epithelia can create flu

257 impact of cilia density and distribution on mucociliary mixing and transport at the tissue scale rem

258 ated increases in ciliary beat frequency and mucociliary movement, two in vitro CF phenotypes that ar

259 downstream of neutrophil elastase, decreased mucociliary parameters in vitro.

260 079 restored nicotine-mediated impairment of mucociliary parameters including mucus transport in vitr

261 f a novel, ovine large animal model.Methods: Mucociliary parameters were measured in human bronchial

262 ke mechanosensory neurons formed part of the mucociliary sole in protostome-deuterostome ancestors an

263 Here, we use the Xenopus tadpole skin mucociliary surface as a model of human upper airway epi

264 Each mucociliary surface that recruits a microbiome such as t

265 However, all mucociliary surfaces are subject to the same physical an

266 sis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrot

267 Mucociliary transport (MCT) is an innate defense mechani

268 tween periciliary liquid (PCL) hydration and mucociliary transport (MCT) rates, a relationship freque

269 Advanced CF is characterized by a deficit in mucociliary transport (MCT), a process that traps and pr

270 ional consequences of reduced sialylation on mucociliary transport (MCT).

271 Increased mucociliary transport accounted for only part of the inc

272 liary proteome to promote ciliary length and mucociliary transport but which is dispensable for norma

273 Cby(-/-) mice exhibit a complete absence of mucociliary transport caused by a marked paucity of moti

274 body component Chibby (Cby) exhibit impaired mucociliary transport caused by defective ciliogenesis,

275 s reveal mechanisms responsible for impaired mucociliary transport in CF and have important implicati

276 Lack of SMGs and mucus strands disrupted mucociliary transport in EDA-KO pigs.

277 d that mucus with abnormal behavior impaired mucociliary transport in newborn CF piglets prior to the

278 Impaired mucociliary transport is a distinguishing sign of cystic

279 ing of the regulation of ciliary beating and mucociliary transport is necessary for identifying new r

280 es simultaneous measurement of rheology with mucociliary transport parameters that we previously dete

281 nucleation in PCD(4), but the regulation of mucociliary transport remains incompletely understood, a

282 g mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of pa

283 cell cultures exhibiting spontaneous, radial mucociliary transport to study the movements of mucus an

284 nt for hydrating airway surfaces, supporting mucociliary transport, and serving as a fluid matrix for

285 We imaged ciliary beat frequency, mucociliary transport, apical Cl(-) permeability, and ai

286 ted secretion in patients with CF may impair mucociliary transport, contributing to increased inciden

287 quired for normal antimicrobial activity and mucociliary transport, two key host defenses that protec

288 action and participates in autoregulation of mucociliary transport.

289 ), SMGs produce abnormal mucus that disrupts mucociliary transport.

290 ugh inhibition of HES6, leading to defective mucociliary transport.

291 l glands has the opposite effect, disrupting mucociliary transport.

292 he two mucins make distinct contributions to mucociliary transport.

293 ibrosis (CF) altered mucus properties impair mucociliary transport.

294 airway mucus, facilitate airway clearance by mucociliary transport.

295 geneous mucus gels and dramatically impaired mucociliary transport.

296 ethered mucus with untethered mucus restored mucociliary transport.

297 reased (500.1 versus 28.3 mg; p = 0.01), and mucociliary transportability increased by 30% (0.76 vers

298 as assessed by microrheometry, and secretion mucociliary transportability was measured in vitro.

299 port velocity, viscoelasticity, or secretion mucociliary transportability with either anesthetic agen

300 unction were illustrated by decreased airway mucociliary velocity and impaired bacterial clearance.