ライフサイエンスコーパス: mucosal immune system

1 development of the intestinal microbiota and mucosal immune system.

2 GHT may play a key role in regulation of the mucosal immune system.

3 LFs) are recently appreciated members of the mucosal immune system.

4 en developed to deliver ETEC antigens to the mucosal immune system.

5 of its host and is subject to control by the mucosal immune system.

6 tion that has led to the concept of a common mucosal immune system.

7 They are potent microbial stimuli of the gut mucosal immune system.

8 uropeptides necessary for maintenance of the mucosal immune system.

9 on the current assumptions about the common mucosal immune system.

10 h the human gut where they interact with the mucosal immune system.

11 olymeric, and likely derived from the common mucosal immune system.

12 the RALT and its relationship to the common mucosal immune system.

13 thogenesis and for targeting vaccines to the mucosal immune system.

14 gle most potent microbial stimuli of the gut mucosal immune system.

15 the GI tract by focusing on the ENS and the mucosal immune system.

16 e composition of the intestinal lumen to the mucosal immune system.

17 critical interface between the lumen and the mucosal immune system.

18 ection are indicative of impaired intestinal mucosal immune system.

19 testinal epithelial cells and the underlying mucosal immune system.

20 ted targeting of vaccines to M cells and the mucosal immune system.

21 ine the functional roles of IL-15 within the mucosal immune system.

22 of IgA-secreting precursor cells through the mucosal immune system.

23 fluences the development and function of the mucosal immune system.

24 helial cells and can be used to modulate the mucosal immune system.

25 in protection upon activation of the common mucosal immune system.

26 e effect is mainly on diseases involving the mucosal immune system.

27 e determining effects on the function of the mucosal immune system.

28 es and involve complex interactions with the mucosal immune system.

29 nder the influence of gut microbiota and the mucosal immune system.

30 tion and homeostasis of the gastrointestinal mucosal immune system.

31 between luminal microbes and the underlying mucosal immune system.

32 ar pathways that regulate homeostasis of the mucosal immune system.

33 is associated with important changes in the mucosal immune system.

34 ractions between intestinal microbes and the mucosal immune system.

35 h have an important modulatory effect on the mucosal immune system.

36 immune system to which it is juxtaposed, the mucosal immune system.

37 with implications for the regulation of the mucosal immune system.

38 nctional compartmentalization within the gut mucosal immune system.

39 ection owing to suboptimal activation of the mucosal immune system.

40 , thus quenching excessive activation of the mucosal immune system.

41 igens and plays a central role in the common mucosal immune system.

42 nteract with the host's epithelial cells and mucosal immune system.

43 f subunit vaccines that stimulate the ocular mucosal immune system.

44 elicits pathologic responses from the normal mucosal immune system.

45 teria are crucial for the development of the mucosal immune system.

46 opment to oral antigens is restricted to the mucosal immune system.

47 tionship between the respiratory and the gut mucosal immune systems.

48 A vaccine that would engage the mucosal immune system against a broad range of HIV-1 sub

49 sociated with a dysregulated response of the mucosal immune system against intraluminal Ags of bacter

50 ompounds are released and gut microbiota and mucosal immune system also play an important role.

51 fic commensal bacteria to maintain an intact mucosal immune system and (3) maternal/infant diet diver

52 as a consequence of interactions between the mucosal immune system and an aberrant local microbiota,

53 ld further characterize the induction of the mucosal immune system and appropriate crop species for d

54 nal discharge are powerful activators of the mucosal immune system and are important risk factors for

55 a highly effective approach to stimulate the mucosal immune system and induce protective immunity aga

56 olitis is dependent on interplay between the mucosal immune system and intestinal bacteria, we invest

57 interactions between enteric ganglion cells, mucosal immune system and intestinal epithelium indicate

58 Altered interactions between the mucosal immune system and intestinal microbiota contribu

59 ng generalized IgA antibody responses in the mucosal immune system and predominantly IgG antibodies i

60 trains in driving phenotype variation in the mucosal immune system and provide a strategy to robustly

61 tion of the complex interactions between the mucosal immune system and the commensal bacteria of the

62 he implications of these data for the common mucosal immune system and the delivery of vaccines again

63 f interactions exists between the intestinal mucosal immune system and the microbiota.

64 action between the various components of the mucosal immune system and the microenvironment.

65 functional distinctness of the systemic and mucosal immune systems and the resultant compartmentaliz

66 ace between the external environment and the mucosal immune system, and emerging data suggest that th

67 ctins as mediators of membrane attack in the mucosal immune system, and provide detailed insight into

68 nment between the intestinal epithelium, the mucosal immune system, and the microbiota with the enter

69 understanding the intestinal epithelium, the mucosal immune system, and the resident microbiota, desc

70 for the nasal activation of the systemic and mucosal immune system, and to design new adjuvants with

71 the main T-cell inductive site of the ocular mucosal immune system, and we investigated their suppres

72 rocessing and absorption, development of the mucosal immune system, angiogenesis, and epithelial rene

73 Thus nutrition, commensal microflora and the mucosal immune system are all intimately connected.

74 Genetic and epigenetic variations in the mucosal immune system are believed to play a significant

75 These data demonstrate that the systemic and mucosal immune systems are highly coordinated following

76 strongest B-cell responses in the intestinal mucosal immune system at challenge and conferred a moder

77 more focused effort to understand the human mucosal immune system before oral tolerance therapy for

78 cles of Peyer's patches are important in the mucosal immune system, but also provide a portal of entr

79 tibodies constitute an important part of the mucosal immune system, but their immunotherapeutic poten

80 We studied the effect of SFB on the mucosal immune system by monoassociating formerly germfr

81 del for regulation of important genes in the mucosal immune system by proinflammatory cytokines.

82 etween the local microbial community and the mucosal immune system by sensing commensal bacteria, reg

83 emonstrate that near-complete restoration of mucosal immune system can be achieved by initiating HAAR

84 components of the mucosal microflora and the mucosal immune system can involve either direct contact

85 Salivary glands, a major component of the mucosal immune system, confer antigen-specific immunity

86 The mucosal immune system constantly surveys the intestinal

87 PPs represents a mechanism whereby the host mucosal immune system controls the continuous dialogue b

88 a large community of commensal microbes, the mucosal immune system deploys a heterogeneous population

89 hese cells is particularly pronounced in the mucosal immune system during acute infection, and the da

90 is limited about the restoration of the gut mucosal immune system during highly active antiretrovira

91 the development of the humoral and cellular mucosal immune systems during neonatal life and to maint

92 During HIV/SIV infection, mucosal immune system dysfunction and systemic immune ac

93 nephropathy is thought to be associated with mucosal immune system dysfunction, which manifests as re

94 earned much about the effects of diet on the mucosal immune system, epithelial function, and the inte

95 ation promotes competent innate and acquired mucosal immune systems, epithelial renewal, barrier inte

96 interactions between the microbiota and the mucosal immune system from infancy to adulthood, highlig

97 (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota.

98 sults identify Lyn as a key regulator of the mucosal immune system, governing pathophysiology in mult

99 malian gastrointestinal tract and associated mucosal immune system harbor a large repertoire of metab

100 tients with inflammatory bowel diseases, the mucosal immune system has inappropriate interactions wit

101 s, and is modified by, enteric flora and the mucosal immune system illuminate the importance of the e

102 Based on the concept of the common mucosal immune system, immunization at various inductive

103 Defects observed in the mucosal immune system in animals with a genetically disr

104 ternal environment; however, the role of the mucosal immune system in chronic lung diseases is incomp

105 To better define disease pathogenesis, the mucosal immune system in G(alpha)i2-deficient mice was s

106 Over time, it has become clear that the mucosal immune system in general and the intestinal immu

107 for a compartmentalization within the common mucosal immune system in humans.

108 ing evidence suggests a central role for the mucosal immune system in mediating immune homeostasis an

109 sorption indicates an important role for the mucosal immune system in the establishment of oral toler

110 The mucosal immune system in the gut has profound local and

111 ight a separation between the peripheral and mucosal immune systems in humans and emphasize the impor

112 immunization to stimulate both systemic and mucosal immune systems, including the genital tract, irr

113 dence for compartmentalization of the common mucosal immune system into "intestinal" vs "nonintestina

114 The mucosal immune system is a unique tolerogenic organ that

115 h pathogens and essential nutrients, yet the mucosal immune system is able to discriminate effectivel

116 The intestinal mucosal immune system is an early target for HIV-1 infec

117 al bacteria, the regulatory component of the mucosal immune system is compromised.

118 gration of the intestinal epithelium and the mucosal immune system is critical for gut homeostasis.

119 Vaccination targeting the gastrointestinal mucosal immune system is especially difficult due to bot

120 The gut mucosal immune system is implicated in its pathogenesis,

121 A fascinating feature of the intestinal mucosal immune system is its ability to guard against in

122 suggest that cross-protection in the common mucosal immune system is mediated by trafficking of B ce

123 the interaction between tumor cells and the mucosal immune system is not well defined.

124 ncy virus (SIV) SIVmac251 to examine how the mucosal immune system is overcome by SIV during acute in

125 ers of the commensal microflora and the host mucosal immune system is rapidly unfolding.

126 The mucosal immune system is relevant for homeostasis, immun

127 A main feature of the common mucosal immune system is that lymphocytes primed in one

128 tainment of infected cells by the peripheral mucosal immune system is the major driver of duration an

129 The gastrointestinal mucosal immune system is the major site for host interac

130 The mucosal immune system is unique, as tolerance is prefere

131 The mucosal immune system is uniquely equipped to discrimina

132 its hinge region - probably derived from the mucosal immune system - is followed by binding of specif

133 recent advances in our understanding of the mucosal immune system, its immunosenescence remains poor

134 helium-derived "self-Ag" gains access to the mucosal immune system, leading to Ag-specific T cell act

135 t contends that primary dysregulation of the mucosal immune system leads to excessive immunologic res

136 his will be pivotal to understanding how the mucosal immune system makes the distinction between comm

137 The common mucosal immune system may be compartmentalized because l

138 indicated that immunotherapies targeting the mucosal immune system may be effective.

139 these interactions are dynamic, because the mucosal immune system, microbiota, and the ENS are devel

140 This mucosal immune system (MIS) in both health and disease i

141 The innate and the adaptive arms of the mucosal immune system must be coordinated to facilitate

142 The mucosal immune system must initiate and regulate protect

143 The mucosal immune system must respond to these diverse sign

144 The host's mucosal immune system must tolerate commensals while fig

145 e propose that NALT is an ancient arm of the mucosal immune system not restricted to terrestrial vert

146 The mucosal immune system of endotherms has evolved organize

147 The mucosal immune system of neonates goes through successiv

148 the recognition of the LPS by the intestinal mucosal immune system of the catfish.

149 urpose of this study was to characterize the mucosal immune system of the engineered neointestine.

150 Targeting of the mucosal immune system of the genital tract with subunit

151 rganism FA isomerization network affects the mucosal immune system of the host.

152 ere is a critical role for components of the mucosal immune system other than PPs in antigen sampling

153 gM repertoires in a noninductive site of the mucosal immune system (parotid gland) become polyclonal

154 The mucosal immune system, particularly the gastrointestinal

155 ltered interaction of luminal flora with the mucosal immune system, persistent mucosal immune activat

156 hosts strongly suggests that the peripheral mucosal immune system plays a critical role in clearing

157 lowing for presentation via a well-developed mucosal immune system, rather than through a disrupted s

158 mmation in Crohn's disease (CD) is caused by mucosal immune system reactivity to luminal antigen and

159 However, the intestinal mucosal immune system remains an important target of HIV

160 t in mucosal sites, we hypothesized that the mucosal immune system remains naive to vaccinia and ther

161 The mucosal immune system represents the first line of defen

162 g targeted therapies to lymphatic tissues in mucosal immune system responsible for production of neph

163 Insight into how the mucosal immune system restricts colonization may provide

164 arises from inappropriate activation of the mucosal immune system resulting in a state of chronic in

165 undance of gut microbiota, and modulates the mucosal immune system, showing potential in preventing c

166 roflora influences specific functions of the mucosal immune system such the production of particular

167 d alterations possibly occurs earlier in the mucosal immune system than in the systemic immune compar

168 Salivary glands are a major component of the mucosal immune system that confer adaptive immunity to m

169 breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenviro

170 IgG (FcRn) have an important function in the mucosal immune system that we have now shown extends to

171 interface between the gut microbiota and the mucosal immune system, there has been great interest in

172 pulations is critical for the balance of the mucosal immune system, this study explores the regulator

173 icobacter pylori colonization may affect the mucosal immune system through modification of microbiota

174 infection may lead to the restoration of the mucosal immune system through reduction of inflammation

175 stand the effect of various exposures to the mucosal immune system throughout life.

176 Oral tolerance refers to the ability of the mucosal immune system to actively inhibit systemic immun

177 T-bet controls the response of the mucosal immune system to commensal bacteria by regulatin

178 cosa severely compromises the ability of the mucosal immune system to control various opportunistic i

179 ence, we reasoned that training the adaptive mucosal immune system to exclude microbes that express f

180 The importance of the mucosal immune system to IBD is established, and evidenc

181 One of the mechanisms used by the mucosal immune system to maintain homeostasis is the sec

182 d be a potentially general mechanism for the mucosal immune system to sense and modulate the response

183 es display intricate adaptations to the host mucosal immune system to successfully reproduce in the g

184 result from an inappropriate response of the mucosal immune system to the normal enteric flora in a g

185 e investigated the effect of morphine on the mucosal immune system using fragment cultures of ileal s

186 al, Morganella morganii, to determine if the mucosal immune system was again stimulated and to evalua

187 Development of the mucosal immune system was examined in mice with partial

188 for HVEM, but its mechanism of action in the mucosal immune system was unknown.

189 anisms of virally induced disruptions in the mucosal immune system, we have evaluated longitudinal ch

190 propria (LP) is a major effector site of the mucosal immune system where antigen-specific and antigen

191 ost basal vertebrate branch with a dedicated mucosal immune system, which comprises immunologically h

192 ered intestine has the capacity to develop a mucosal immune system with an immunocyte population simi

193 stasis between intestinal microbiota and the mucosal immune system, with both environmental and genet