ライフサイエンスコーパス: mucosal tissue

1 moval force of ~4.5 N cm(-2) from intestinal mucosal tissue.

2 (NE) have been reported in inflamed colonic mucosal tissue.

3 cells (DCs) that reside within epidermal and mucosal tissue.

4 ved regenerative wound healing mechanisms in mucosal tissue.

5 ion assay, did not fully predict activity in mucosal tissue.

6 rap the bacteria both inside and outside the mucosal tissue.

7 mune cell behavior within the complex airway mucosal tissue.

8 bicans is a well-tolerated resident of human mucosal tissues.

9 tissue structure and function, especially in mucosal tissues.

10 r functions at peripheral sites, such as gut mucosal tissues.

11 macrophage chemoattractant that operates in mucosal tissues.

12 s during viral transmission, particularly in mucosal tissues.

13 LDL receptor-related protein 6 (LRP6) in the mucosal tissues.

14 eric virus in primary human target cells and mucosal tissues.

15 e primarily CD8(+) and numerous in blood and mucosal tissues.

16 S727P each contribute to SIV's targeting to mucosal tissues.

17 sues, including lung, lymph nodes, and other mucosal tissues.

18 to innate immunity, including protection of mucosal tissues.

19 d targeted drug and nucleic acid delivery to mucosal tissues.

20 cules and that preferentially resides within mucosal tissues.

21 t and/or detection of pathogenic bacteria in mucosal tissues.

22 al system for effector and memory T cells in mucosal tissues.

23 her viral infections that enter the body via mucosal tissues.

24 roteins, lipids, and genomic DNA in skin and mucosal tissues.

25 RNA expression predominantly in lymphoid and mucosal tissues.

26 (+) T cells in lymphoid and gastrointestinal mucosal tissues.

27 the systemic circulation and trafficking to mucosal tissues.

28 tion of X4-tropic strain transmission across mucosal tissues.

29 te to the hydrophilic character of mucins in mucosal tissues.

30 tion of memory CD4 T cells in peripheral and mucosal tissues.

31 itment of IgA ASC varies dramatically within mucosal tissues.

32 ss and deliver heterologous antigens to host mucosal tissues.

33 ication and repair and regenerate intestinal mucosal tissues.

34 ion by DCs indirectly controls MCp homing to mucosal tissues.

35 cells isolated from blood, lymph nodes, and mucosal tissues.

36 y CD8 T cell quality and surveillance within mucosal tissues.

37 enotypes and functions of dendritic cells in mucosal tissues.

38 ubsets, activated B lymphocytes, and various mucosal tissues.

39 le in host-pathogen interactions in skin and mucosal tissues.

40 ld-type mice due to defective transport into mucosal tissues.

41 c cells (DCs) significantly increased in the mucosal tissues.

42 of inducing both T cell and Ab responses in mucosal tissues.

43 requency SIV-specific CTL responses in these mucosal tissues.

44 e, and IL-5 production was skewed toward the mucosal tissues.

45 ignaling pathways in inflammation focused on mucosal tissues.

46 kin can recruit protective CD8(+) T cells to mucosal tissues.

47 ry attachment of the bacterial cell to human mucosal tissues.

48 ions appear to characterize most diseases of mucosal tissues.

49 the full cellular repertoire of human nasal mucosal tissues.

50 well distant and functionally different than mucosal tissues.

51 nd HbetaD2 from colonic epithelial cells and mucosal tissues.

52 l types to encounter virus in the peripheral mucosal tissues.

53 poorly protective against HIV-1 infection of mucosal tissues.

54 present in the inner mucus layer and invaded mucosal tissues.

55 heir potential to block ex vivo challenge of mucosal tissues.

56 can reactivate to cause recurrent lesions in mucosal tissues.

57 of tissue resident memory CD8 T cells within mucosal tissues.

58 of lymphocytes, and thus vaccine efficacy in mucosal tissues.

59 ntification of the microorganisms colonizing mucosal tissues.

60 tence of gut bacteria than simply protecting mucosal tissues.

61 are active within hours after infections in mucosal tissues.

62 ns very differently in the context of intact mucosal tissues.

63 om 50 samples of normal pancreas or duodenal mucosal tissues, 7 samples of chronic pancreatitis, and

64 rom the PNS back via axons to the peripheral mucosal tissues, a process mediated by kinesin motors.

65 Cancers arising in mucosal tissues account for a disproportionately large f

66 ough the penile, rectal, or vaginal/cervical mucosal tissue after sexual exposure.

67 e length may limit regenerative potential of mucosal tissues after acute injury.

68 rease in the total magnitude of TRM in mouse mucosal tissues after boosting, suggesting that the memo

69 n-specific responses were mainly confined to mucosal tissues, again regardless of the route of immuni

70 abundantly present in genital and intestinal mucosal tissue and are among the first innate immune cel

71 Changes in host mucosal tissue and commensals posttransplant have been a

72 ntent were highly mucoadhesive to sublingual mucosal tissue and could withstand extensive washing, le

73 oding interleukin-10 safely penetrated local mucosal tissue and had therapeutic benefit in this DSS m

74 e expansion of B-lineage cells in the airway mucosal tissue and lead to the formation of inducible ly

75 tains the swift lymphocyte-based invasion of mucosal tissue and lymphatic organs, whereas C sustains

76 ivation, TNF production, and NO synthesis in mucosal tissue and macrophages, as well as systemic dysr

77 es to a given viral pathogen within the same mucosal tissue and reveal a specialized role for monocyt

78 oduced in response to microbial infection of mucosal tissue and skin.

79 D4(+) T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subset

80 microbes and other environmental insults at mucosal tissues and are thus thought to play a local imm

81 als or pathogens that commonly colonize host mucosal tissues and avoid rapid clearance, in part by st

82 with decreased expression in peripheral and mucosal tissues and DNA hypermethylation in CD patients

83 lls in mammals that reside preferentially in mucosal tissues and express an invariant Valpha paired w

84 ate and antigen-specific memory responses in mucosal tissues and in the blood.

85 causes a localized acute viral infection in mucosal tissues and induces a recall response, since mos

86 ion molecules that are associated with other mucosal tissues and inflammatory sites, which suggests t

87 ely expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of imm

88 ly in blood and BM and at variable levels in mucosal tissues and LNs.

89 To protect mucosal tissues and maintain immune tolerance, animal ho

90 pregulated on T cells in both peripheral and mucosal tissues and maintained at high levels on SIV-spe

91 ily cytokine, is constitutively expressed in mucosal tissues and other organs in healthy humans and a

92 We analyzed primary human fetal lymphoid and mucosal tissues and performed phenotypic, functional, an

93 subset of T cells associated with epithelial mucosal tissues and play a prominent role in both promot

94 a by conferring protection against injury to mucosal tissues and positively calibrating the responsiv

95 nervate the skin, joints, bones, muscles and mucosal tissues and protects organisms from noxious stim

96 s by first promoting their accumulation into mucosal tissues and second by sustaining expression of B

97 th effector and memory T cells in intestinal mucosal tissues and showed higher frequencies of systemi

98 uitous commensal fungus that colonizes human mucosal tissues and skin, can become pathogenic, clinica

99 ld (M) cells are epithelial cells present in mucosal tissues and specialized for the capture of lumin

100 The drug concentration in the receptive mucosal tissues and target immune cells for HIV is criti

101 dies are synthesized in preference to IgG in mucosal tissues and why the IgE is so tenaciously retain

102 e very abundant in humans, tend to reside in mucosal tissues and, therefore, were named mucosal-assoc

103 dies typically sample drug in luminal fluid, mucosal tissue, and blood.

104 d on tumour when compared to adjacent normal mucosal tissue, and fusobacteria and beta-Proteobacteria

105 colon cancers compared with those in normal mucosal tissue, and low levels of RIP140 expression in a

106 nd potently respond to pathogen infection in mucosal tissues, and are prominently induced by both tub

107 t play important roles in innate immunity in mucosal tissues, and in the maintenance of tissue and me

108 elite control, robust cellular responses in mucosal tissues, and no disease.

109 pe is widespread, as goblet cells of several mucosal tissues appear engorged and Clara cells accumula

110 ctivated CD4 T cells present in lymphoid and mucosal tissues are major targets for infection.

111 Mucosal tissues are subject to frequent pathogen exposur

112 Mucosal tissues are the primary route of transmission fo

113 Mucosal tissues are the primary site of natural HIV tran

114 summarize recent reports incriminating these mucosal tissues as the initial site of autoantibody gene

115 ine jejunal and colonic smooth muscle and/or mucosal tissues as well as transcriptomes from the assoc

116 e and esophageal submucosa compared with gut mucosal tissues, as well as detectable TGF-beta1 in norm

117 a critical role in the development of other mucosal tissue-associated innate lymphocytes.

118 placebo, histological examination of gastric mucosal tissue biopsies provided good sensitivity and sp

119 not only able to inhibit direct infection of mucosal tissue but was able to prevent dissemination of

120 te populations from central immune organs or mucosal tissues but instead exerts a potent antimicrobia

121 subsets of CD4+ T cells that are abundant in mucosal tissues but rare in peripheral lymphoid tissues.

122 lumen of the genital tract than in cervical mucosal tissue, but lumen TLR mRNA levels did not change

123 knockout not only decreased Cdc42 levels in mucosal tissues, but it also inhibited repair of damaged

124 tricted iNKT cells are tightly controlled in mucosal tissues, but the mechanisms have been largely un

125 Lymphocytes were also assessed in GI mucosal tissues by in situ staining in histologic specim

126 al tract, which enables invasion of delicate mucosal tissues by pathogenic organisms.

127 is a mechanism by which C. albicans invades mucosal tissues by promoting the proteolytic degradation

128 etroviral drugs, however, act against HIV in mucosal tissue/cells.

129 ose (10 mg) infused intraduodenally prior to mucosal tissue collection.

130 The lung is a mucosal tissue colonized by a diverse bacterial communit

131 ynamic (PD) model was developed by measuring mucosal tissue concentrations of tenofovir, emtricitabin

132 Mucosal tissues constitute the largest interface between

133 Our in vitro 3D oral mucosal tissue construction studies further demonstrated

134 immunoregulatory lectin widely expressed in mucosal tissues, contributes to Y. enterocolitica pathog

135 nique T-cell receptor (TCR)-bearing cells in mucosal tissues could influence the selection and expans

136 C. difficile infection, as are parameters of mucosal tissue damage and inflammation.

137 Previous studies have implicated hypoxia in mucosal tissue damage resulting from both acute and chro

138 ons of CCR5(+) and CCR6(+) CD4(+) T cells in mucosal tissues, decreases in CD4(+) T cells producing T

139 ranscriptase-PCR products obtained from oral mucosal tissues, disclosing three mucosal alpha-defensin

140 Microbial colonization of mucosal tissues during infancy plays an instrumental rol

141 has been shown to be secreted in intestinal mucosal tissues during inflammation, its potential role

142 tected at high frequency in second-trimester mucosal tissues (e.g., the intestine and lung).

143 lative inhibition of parasite replication in mucosal tissues early after oral T. cruzi challenge, usi

144 it is generally accepted that epithelial and mucosal tissue egress is regulated by expression of the

145 hoalveolar lavage, respectively), as well as mucosal tissue (endobronchial biopsies).

146 In intact mucosal tissues, epithelial cells are anatomically posit

147 In mucosal tissues, epithelial M cells capture and transpor

148 ial structure, e.g. soils, sediments, animal mucosal tissue, etc.

149 Few T cells in any mucosal tissue examined express CCR10.

150 lamina propria mononuclear cells (LPMCs) and mucosal tissue explants were incubated with otelixizumab

151 sis assays, and cell-associated infection of mucosal tissue explants.

152 >/=98% of the population achieved protective mucosal tissue exposure by the third daily dose of tenof

153 n diverse gastrointestinal and nonintestinal mucosal tissues express the chemokine MEC/CCL28.

154 he vast majority of IgA production occurs in mucosal tissue following T cell-dependent and T cell-ind

155 delta2)T cells proliferate and accumulate in mucosal tissues following microbial activation.

156 uniform and longer-lasting drug delivery to mucosal tissues following topical administration.

157 eration sequencing of normal-looking colonic mucosal tissue from mice treated with the carcinogen azo

158 onstitutive expression of trout IL-17A/F2 in mucosal tissues from healthy fish, suggesting a potentia

159 Similarly, colonic mucosal tissues from mice exposed to dextran sulfate sod

160 ng proteins involved in autophagy in colonic mucosal tissues from patients with sporadic CRC colonize

161 of investigation have separately implicated mucosal tissues from varying anatomic locations as possi

162 cosal epithelia from the hDsg3 mice, but not mucosal tissues from WT mice, as detected by indirect im

163 of the HIV-specific CD8+ T-cell responses in mucosal tissues has been described, few studies have inv

164 HIV-1 infected individuals, its role in the mucosal tissues has not been investigated.

165 ntibody blocking of HIV-1 acquisition within mucosal tissue have not been defined.

166 ular sites implicated in disease initiation, mucosal tissues have garnered increasing attention.

167 findings thus suggest that DC subsets within mucosal tissues have unique immune inductive capacities.

168 ations were increased in nasal secretion and mucosal tissue homogenates in patients with chronic rhin

169 eukocytes in the human body are localized in mucosal tissues; however, the roles of eosinophils in hu

170 istration of MPA prior to viral infection of mucosal tissue impairs DC activation, virus-specific T c

171 epithelial cell monolayers and human colonic mucosal tissue in vitro In contrast, ursodeoxycholic aci

172 FcRn thus has a primary role within mucosal tissues in activating local immune responses tha

173 e the role of human mast cells isolated from mucosal tissues in mediating HIV-1 trans-infection of CD

174 Rarely, LS has been observed to affect mucosal tissues in the mouth and the penile urethra.

175 sors had limited innate immune activation in mucosal tissues in the periphery, which was associated w

176 GPR35 is expressed in mucosal tissues, in CXCL17-responsive monocytes, and in

177 years in both peripheral blood and multiple mucosal tissues, including colorectal, duodenal, and vag

178 CD8 T cell responses both in systemic and in mucosal tissues, including intraepithelial and lamina pr

179 n-specific CD8(+) T cells that accumulate in mucosal tissues, including the female genital and respir

180 overviews the complex structural features of mucosal tissues, including the structure of mucus, the e

181 In human mucosal tissue, inflammation increased the secretion of

182 accumulation, prostaglandin E(2) production, mucosal tissue injury, and markers of oxidative stress w

183 an initial hypoperfusion-related intestinal mucosal tissue injury.

184 ibute to anti-helminth immunity, maintaining mucosal tissue integrity, and adipose tissue browning.

185 tent humoral and cellular immune response in mucosal tissue is important for the development of an ef

186 al mutant's deficiency in colonizing colonic mucosal tissue is likely due to its increased susceptibi

187 Cancer of mucosal tissues is a major cause of worldwide mortality

188 The ability of Candida albicans to invade mucosal tissues is a major virulence determinant of this

189 of circulating CD8(+)gammadelta T cells for mucosal tissues is due, at least in part, to selective d

190 zed CD4+ T cell depletion from the blood and mucosal tissues is not sufficient to induce AIDS in this

191 infections even though their migration into mucosal tissues is tightly regulated.

192 ly, characterized by hyphal invasion of oral mucosal tissue, is the most common opportunistic infecti

193 , which is expressed by epithelia in diverse mucosal tissues, is selectively chemotactic for IgA Ab-s

194 In genital-mucosal tissues, it initiates colonization of epithelial

195 in Th17 cell lineage priming in the skin and mucosal tissues, it was not required for Th17 cell primi

196 However, despite their abundance in mucosal tissue, little information is available about th

197 with enhanced FcRn binding has increased gut mucosal tissue localization, which improves protection a

198 t distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph no

199 ntibody blocking of HIV-1 acquisition within mucosal tissue may prove critical to effective vaccine d

200 ular immune responses in both peripheral and mucosal tissues may be important for the development of

201 d replication across a range of cellular and mucosal tissue models.

202 six decades of life in blood, lymphoid, and mucosal tissues obtained from 56 individual organ donors

203 ue analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, r

204 icant T-cell lymphopenia was observed in the mucosal tissue of patients with ICL by flow cytometry an

205 can be reproducibly sampled from intestinal mucosal tissue of rhesus monkeys obtained under endoscop

206 e used flow cytometric analysis of sinonasal mucosal tissues of 29 CRS patients and 5 controls to qua

207 oimmune vesiculobullous disease that affects mucosal tissues of adults and rarely presents in childre

208 y the dendritic cells (DC) isolated from the mucosal tissues of aging animals.

209 en-specific CD8(+) T cells were found in the mucosal tissues of all immunized macaques regardless of

210 elling evidence that the microenvironment of mucosal tissues of allergic disease favors class switchi

211 These cells accumulate in mucosal tissues of allergic reactions, where immunoglobu

212 Deltagamma NK cells in mucosal tissues of chronically infected animals exhibite

213 These GI mucosal tissues of chronically SIVmac-infected rhesus mo

214 Compared with mucosal tissues of controls, mucosa from patients with I

215 in human gastric cancer tissues and gastric mucosal tissues of H. pylori infected C57BL/6 mice.

216 antiviral factors would be most abundant in mucosal tissues of HIV controllers.

217 that (i) Gag-specific responses dominate in mucosal tissues of HIV controllers; (ii) there is extens

218 tion with Streptococcus pneumoniae the nasal mucosal tissues of mice support two populations of pneum

219 s of p53 and PUMA were increased in inflamed mucosal tissues of mice with colitis and in patients wit

220 In mucosal tissues of normal rhesus macaques, we found CD4(

221 GF and NTRK1, are significantly increased in mucosal tissues of patients with IBS.

222 to the Gag 181 tetramer, particularly in the mucosal tissues of some of the macaques infected by SIV(

223 V) inoculation are earliest and strongest in mucosal tissues of the genital tract and lowest in syste

224 We show that the CD8(+) T cell repertoire in mucosal tissues of uninfected rhesus monkeys is oligoclo

225 tors that are important for migration to the mucosal tissues particularly the small intestine.

226 e of inflammation as a controller of enteric mucosal tissue patterning requires understanding the und

227 Three regulatory factors associated with mucosal tissues, PGE(2), IL-10, and TGFbeta, inhibited t

228 y combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematica

229 Because it is thought that mucosal tissues play a fundamental role in early HIV/SIV

230 Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest pha

231 greater inhibitory potencies in cellular and mucosal tissue pre-clinical models than the parent seque

232 on was pronounced in lymphoid and colorectal mucosal tissues, preferential sites of virus replication

233 mation of functional resident CD8 T cells in mucosal tissues protected mice from a model of CD8 T cel

234 s microenvironmental stimuli in lymphoid and mucosal tissues provide support for HIV-1 replication.

235 by dendritic cells (DCs) that patrol various mucosal tissues remains unclear.

236 or 2 (TFF2), a well-established regulator of mucosal tissue repair.

237 Mucosal tissues require constant immune surveillance to

238 Innate resistance to Candida albicans in mucosal tissues requires the production of interleukin-1

239 ons with viruses, such as HIV-1, that target mucosal tissue result in intestinal epithelial barrier b

240 Challenge of primary human mucosal tissues revealed significantly higher levels of

241 ation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and

242 g of innate immune responses in human rectal mucosal tissues (RM) and their contributions to promotin

243 proteins in relation to PMN infiltration in mucosal tissue samples from patients with active IBD.

244 of phospho-Smad2 (days 3 and 7) in IEC from mucosal tissue sections of B. vulgatus-monoassociated ra

245 lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory

246 Gene profiling of oral mucosal tissue showed strong induction of Th17 signature

247 istochemical data on hBD2 expression in oral mucosal tissue shows that hBD2 is constitutively express

248 of NK cells from blood, lymphoid organs, and mucosal tissue sites from 60 individuals, we identify ti

249 iety of sites throughout the body, including mucosal tissues such as the lung.

250 c IgA Ab-forming cells were also detected in mucosal tissues such as the nasal passages (NPs), the su

251 de lymph nodes, spleen, Peyer's patches, and mucosal tissues such as the nasal-associated lymphoid ti

252 Mucosal tissues, such as the lung, are continually expos

253 Its strategic expression in mucosal tissues suggests that it is involved in innate i

254 opical plasmid DNA vaccine delivery to human mucosal tissue surfaces, and that this application may p

255 In mucosal tissues, surprisingly, Rh-alpha4beta7 did not im

256 respective study drug was injected into the mucosal tissue surrounding the surgical site prior to su

257 We present here an analysis of lymphoid and mucosal tissue T cells derived from pediatric organ dono

258 ctor alpha was low and was even lower in the mucosal tissue than in blood or spleen of some SIV(mac25

259 sponse, with a magnitude that was greater in mucosal tissues than in peripheral blood.

260 ocytes, eosinophils and basophils into nasal mucosal tissue that results in the late-phase allergic r

261 IgA is produced primarily by PCs residing in mucosal tissues that are also thought to circulate in th

262 T) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands.

263 t fully characterized, especially in genital mucosal tissues (the main HIV-1 entry portal on sexual t

264 of PD-1 expression in lymph nodes and rectal mucosal tissue, the major sites of virus replication, wa

265 In mucosal tissues, the earliest demonstrable FIV-bearing c

266 They include the homing of mast cells to mucosal tissues, the local synthesis of IgE, the inducti

267 st cells are strategically positioned within mucosal tissues, the major interface with the external e

268 n of memory CD4+ T cells occurs primarily in mucosal tissues, the major reservoir for memory CD4+ T c

269 sure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic

270 responding to an infection of peripheral or mucosal tissues they were designed to protect.

271 and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF

272 Mast cells are found in connective and mucosal tissues throughout the body.

273 T mice, induces suprabasilar acantholysis in mucosal tissues, thus confirming the pathogenicity of mP

274 n addition to its proinflammatory actions in mucosal tissue, TNF is important for liver regeneration.

275 o understand the virus-specific responses in mucosal tissues to facilitate devising strategies to pre

276 an be ferried via normal DC trafficking from mucosal tissues to lymphoid organs in vivo.

277 from 10(4)-10(5) single cells from blood or mucosal tissues using dense arrays of subnanoliter wells

278 cell population maintained in the peripheral mucosal tissues was attributable to a MA delivered AdHu5

279 estigate the effects of BPs on cells of oral mucosal tissue, we studied the effect of pamidronate (PA

280 way hyperreactivity are allergic diseases of mucosal tissues, we determined whether an allergic disea

281 HIV-1 DNA copies in foreskin and cervical mucosal tissue were compared and the infected cell pheno

282 Mast cells isolated from gut mucosal tissues were found to express a variety of HIV-1

283 Vmac251 acquisition, whereas virus levels in mucosal tissues were inversely correlated with antienvel

284 We found that nasal mucosal tissues were susceptible to HCMV infection, with

285 nt mice, although Th2 cytokine elevations in mucosal tissues were unaffected.

286 migrate to and reside within connective and mucosal tissues, where they differentiate and respond to

287 entium infection, NK cells were recruited to mucosal tissues, where they expressed a diversity of imm

288 ility, such as the semipermeable surfaces of mucosal tissues which are adapted for adsorption of nutr

289 s biofilms on indwelling medical devices and mucosal tissues, which serve as an infectious reservoir

290 re also efficient in preventing infection of mucosal tissues, while the protective efficacy of bnAbs

291 ation and suggest that directed targeting to mucosal tissues will be needed for effective vaccination

292 the chronic phase of HIV infection supplies mucosal tissues with short-lived CCR5+ CD4+ effector cel

293 overlap between CD8(+) T cells in blood and mucosal tissues, with responses to immunodominant epitop

294 mavirus (HPV) infection across cutaneous and mucosal tissues within individuals has not been examined

295 ection and removal of memory CD4+ T cells in mucosal tissues within the first three weeks of infectio

296 PPs allow enhanced drug and gene delivery to mucosal tissues without diminishing the protective funct

297 induce strong HIV-specific CD8(+) T cells in mucosal tissues without increasing the availability of t

298 ow that IL-15 complexes delivered locally to mucosal tissues without reinfection is an effective stra

299 Gram-positive bacteria colonize mucosal tissues, withstanding large mechanical perturbat

300 t induce potent cellular immune responses in mucosal tissue would have broad application for vaccines