ライフサイエンスコーパス: multicellularity

1 e intricate behaviors coordinating bacterial multicellularity.

2 l roles in the generation and maintenance of multicellularity.

3 ich evolved in tandem with the transition to multicellularity.

4 pression is essential for the maintenance of multicellularity.

5 oviding a necessary step in the evolution of multicellularity.

6 ic mechanisms, facilitated the transition to multicellularity.

7 y during the transition from single cells to multicellularity.

8 teria are a beautiful example of prokaryotic multicellularity.

9 select for the evolution of undifferentiated multicellularity.

10 PCD in microbes, including the evolution of multicellularity.

11 aiming to better understand genomic basis of multicellularity.

12 atterns as genomic and evolutionary basis of multicellularity.

13 cine algae coevolved with the acquisition of multicellularity.

14 in basic processes associated with metazoan multicellularity.

15 pmental changes relevant to the evolution of multicellularity.

16 not cause potassium leakage failed to induce multicellularity.

17 ve played roles in the evolution of metazoan multicellularity.

18 rst the eukaryotic cell and later eukaryotic multicellularity.

19 ng the evolution of cell differentiation and multicellularity.

20 y have contributed to the advent of metazoan multicellularity.

21 tural novelties in Eukarya perhaps linked to multicellularity.

22 rons and ectopic expression at the origin of multicellularity.

23 ehavior during the earliest experiments with multicellularity.

24 Xdh gene in eukaryotes, before the origin of multicellularity.

25 ts that they are associated with the rise of multicellularity.

26 one of the early steps in the development of multicellularity.

27 ultrastructure when examining the origins of multicellularity.

28 erefore be an early step in the evolution of multicellularity.

29 e worm may have contributed to the advent of multicellularity.

30 ry prerequisite for the evolution of complex multicellularity.

31 ve originated before the origins of obligate multicellularity.

32 the assumption that UFMylation is linked to multicellularity.

33 s a key challenge in the study of artificial multicellularity.

34 up of heterokont protists exhibiting complex multicellularity.

35 rongly suppress the evolution of macroscopic multicellularity.

36 lluminates an essential process of embryonic multicellularity.

37 oups as model organisms for the evolution of multicellularity.

38 gulation by microRNAs (miRNAs) expanded with multicellularity.

39 o refine our preconceptions of conflict-free multicellularity.

40 illus subtilis, a model system for bacterial multicellularity.

41 elative of animals that displays aggregative multicellularity.

42 Inter-tissue interaction is fundamental to multicellularity.

43 s essential in the unicellular transition to multicellularity.

44 on of synthetic biological systems with true multicellularity.

45 plex was key to the emergence of animal-type multicellularity.

46 as and probably lost during the evolution of multicellularity.

47 Stem cells are a hallmark of animal multicellularity.

48 sed in the framework of major transitions to multicellularity.

49 aptation in the evolution of volvocine algal multicellularity.

50 rtant model system to study the evolution of multicellularity.

51 al process in the course of the emergence of multicellularity.

52 ergent selective driver for undifferentiated multicellularity.

53 the metazoan and plant kingdoms to establish multicellularity.

54 rs may have played a role in some origins of multicellularity.

55 ions, and was essential in the transition to multicellularity.

56 bacteria identify kin and transition towards multicellularity.

57 l adhesion is essential for establishment of multicellularity.

58 d complexity due to compartmentalization and multicellularity.

59 itions in evolution such as the emergence of multicellularity.

60 essure that may have driven the evolution of multicellularity.

61 ting such behavior prior to the emergence of multicellularity.

62 nd was necessary for the evolution of animal multicellularity.

63 s was already in place at the dawn of animal multicellularity.

64 ecological context during the transition to multicellularity.

65 for a long time was considered a hallmark of multicellularity.

66 during the initial step in the evolution of multicellularity.

67 s to have had an impact during the origin of multicellularity.

68 infections during the multiple emergences of multicellularity.

69 ther mechanistic studies on the emergence of multicellularity.

70 ms for understanding the evolution of animal multicellularity.

71 ping clusters may often be the first step to multicellularity.

72 not necessarily alongside, the emergence of multicellularity.

73 e challenges in how to organize and maintain multicellularity.

74 ulatory systems and the evolution of complex multicellularity.

75 organism, and this acts as a gating step for multicellularity.

76 ts, and rarer metazoan innovations linked to multicellularity.

77 key factor underlying the diverse origins of multicellularity.

78 DGRs are also implicated in the emergence of multicellularity(6,7).

79 ough the prenylation of ROP is important for multicellularity, a higher threshold of active ROP is re

80 ve demarcated the genetic toolkit for animal multicellularity, a select set of a few hundred genes fr

81 emical, and mechanistic basis of prokaryotic multicellularity, a topic that has garnered considerable

82 the long-term divergent evolution of complex multicellularity across the tree of life.

83 ing bodies in a process known as aggregative multicellularity (AGM).

84 ment, expression pattern diversification and multicellularity, aiming to better understand genomic ba

85 entiation is one of the hallmarks of complex multicellularity, allowing individual organisms to capit

86 sition onto biotic sources, while eukaryotic multicellularity allows iron recycling within an organis

87 However, multicellularity also necessitates intercellular depende

88 utions to genetic hurdles imposed by complex multicellularity among independently evolved lineages.

89 eby reducing maintenance energy, which makes multicellularity an emergent property of life itself.

90 Coming together amplifies the benefits of multicellularity and allows social clusters to collectiv

91 the major isoform responsible for regulating multicellularity and cell contractility during sprouting

92 that chlorophytes acquired macroscopic size, multicellularity and cellular differentiation nearly a b

93 Volvox, a model system for the evolution of multicellularity and cellular differentiation.

94 entally responsive molecular determinants of multicellularity and contribute to the natural morpholog

95 Here, we focus on the origin of multicellularity and develop a mechanistic model to exam

96 How multicellularity and development are interconnected in e

97 ework for investigating the origin of animal multicellularity and development.

98 ed for the investigation of the evolution of multicellularity and development.

99 a phenomenon that underpins the evolution of multicellularity and developmental robustness.

100 fossils for reconstructing the evolution of multicellularity and division of labor in cyanobacteria.

101 veal the importance of TFs to the origins of multicellularity and embryonic development.

102 including the emergence of eukaryotic cells, multicellularity and eusociality.

103 lucidate the core genetic program of complex multicellularity and fruiting body development in mushro

104 and facilitating evolutionary transitions to multicellularity and germ-soma differentiation in the vo

105 he major evolutionary transition to obligate multicellularity and had more cell types, a higher likel

106 ncidentally led to the evolution of enhanced multicellularity and increased virulence.

107 Our work sheds light on the evolution of multicellularity and longitudinal division in bacteria,

108 e identify genes and alleles associated with multicellularity and longitudinal division, including th

109 model for investigating the origin of animal multicellularity and mechanisms underlying cell differen

110 e editing in the evolution of fungal complex multicellularity and provide empirical evidence that res

111 ia broadens our understanding of prokaryotic multicellularity and provides insight into how multicell

112 al control mechanism governing the switch to multicellularity and raises the possibility that YlbF, Y

113 genetic features underlying the evolution of multicellularity and regeneration.

114 cadherins, which are essential for metazoan multicellularity and restricted to metazoans and their c

115 rsification and the intertwined evolution of multicellularity and sexual reproduction.

116 at differ only in the presence or absence of multicellularity and somatic differentiation, permitting

117 ggest a separation of the genomic origins of multicellularity and terrestrialization in plants.

118 lly harmful, they permitted the evolution of multicellularity and the colonization of land.

119 ion of orthologs of genes known to establish multicellularity and tissue architecture in metazoans.

120 ce for the evolutionary transition to animal multicellularity and tissue evolution.

121 cellular matrix that is essential for animal multicellularity and tissue evolution.

122 to the understanding of natural evolution of multicellularity and to manipulating cell sedimentation

123 ordinated expression of strongly interacting multicellularity and unicellularity processes was lost i

124 complex RNA-silencing systems evolved before multicellularity and were a feature of primitive eukaryo

125 etics of traits relevant to the evolution of multicellularity, and genetic and genomic resources avai

126 s membrane-less organelles, in the origin of multicellularity, and in protein conformation-based tran

127 wth via different strategies, including true multicellularity, and multiple types of giant-celled for

128 ation, the evolution of the eukaryotic cell, multicellularity, and the origin of human groups with la

129 s, the Palmophyllales, with a unique form of multicellularity, and typically found in deep water.

130 ful independent solutions to the problems of multicellularity - animals and higher plants.

131 Multicellularity appeared early and repeatedly in life's

132 Evolution of multicellularity appears to have been accompanied by a s

133 of living myocardium that retain the native multicellularity, architecture and physiology of the hea

134 emonstrate that inhibition by virophages and multicellularity are effective antiviral strategies that

135 ins and the genetic underpinnings of complex multicellularity are incompletely known.

136 nges that ultimately led to the evolution of multicellularity are not known.

137 l adhesion, aggregation-based mechanisms for multicellularity are susceptible to mixing with genetica

138 lular relatives indicate that transitions to multicellularity are typically associated with increases

139 Multicellularity arose as a result of adaptive advantage

140 d of modular domains have evolved along with multicellularity as a method to facilitate increasing in

141 lability is a key factor in the evolution of multicellularity, as larger and more sophisticated organ

142 ns must be key players in the development of multicellularity because they are well positioned to for

143 nscription factors are key players in animal multicellularity, being members of the T-box family that

144 verge to control complex processes including multicellularity, biofilm formation, and virulence.

145 Integrin-mediated adhesion is as ancient as multicellularity, but it was not always as complex as it

146 tions have been identified in the context of multicellularity, but they have been treated very simila

147 gg, the social amoeba Dictyostelium achieves multicellularity by the aggregation of approximately 10(

148 With increasing specialization and multicellularity, C3 evolved a secretory capacity that a

149 ted cells.(5) Alternatively, or in addition, multicellularity can emerge from a series of mitotic div

150 Here we show that de novo origins of simple multicellularity can evolve in response to predation.

151 We argue that multicellularity can prevent the victory of such mutants

152 ife histories, including social behavior and multicellularity, can only be understood in the appropri

153 At the origin of multicellularity, cells may have evolved aggregation in

154 The advent of complex multicellularity (CM) was a pivotal event in the evoluti

155 has been to understand how the evolution of multicellularity conferred fitness advantages.

156 lar, soma-producing strains, suggesting that multicellularity confers evolutionary stability to somat

157 g modular toolkits for two key mechanisms in multicellularity, contact-dependent signaling and specif

158 "Complex multicellularity," conventionally defined as large organ

159 In this way, multicellularity could have originated.

160 These results suggest that multicellularity could have played a key role in trigger

161 Our results suggest that cryptic multicellularity could readily evolve and originate well

162 ars ago.(1)(,)(2)(,)(3)(,)(4) While obligate multicellularity could result from cell-cell adhesion, a

163 nities do not satisfy the strict criteria of multicellularity developed by multi-level selection theo

164 Here it is suggested that multicellularity discourages selection against weak muta

165 and possible interplay between the origin of multicellularity, diversification of cyanobacteria, and

166 ps of cells using actomyosin predated animal multicellularity during evolution.

167 A-mediated contractile forces in maintaining multicellularity during sprouting and highlight the cent

168 m However, it is still poorly understood why multicellularity emerged in these amoebas while the majo

169 The evolution of multicellularity enabled specialization of cells, but re

170 The transition to multicellularity enabled the evolution of large, complex

171 Obligate multicellularity evolved at least five times in eukaryot

172 ism has become a model for understanding how multicellularity evolved in the animal lineage.

173 We do not know how or why multicellularity evolved.

174 The primitive 'multicellularity' exhibited by certain cellulolytic micr

175 Current explanations for multicellularity focus on two aspects of development whi

176 genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the e

177 s enriched among the cell-autonomous and the multicellularity genes, respectively.

178 enecks between generations, the evolution of multicellularity greatly reduces the effective populatio

179 Organismal-grade multicellularity has been achieved only in animals, plan

180 ot in laboratory strains, an indication that multicellularity has been lost during domestication of B

181 The evolution of complex multicellularity has been one of the major transitions i

182 Multicellularity has been one of the most important inno

183 Complex multicellularity has emerged independently across a few

184 Multicellularity has emerged multiple times in evolution

185 iridiplantae comprise unicellular algae, and multicellularity has evolved independently in the two cl

186 Aggregative multicellularity has evolved multiple times in diverse g

187 Multicellularity has evolved multiple times, but animals

188 The evolution of multicellularity has given rise to a remarkable diversit

189 The transition to multicellularity has occurred numerous times in all doma

190 Studies on the origin of animal multicellularity have increasingly focused on one of the

191 l amoebas (Dictyostelia) display conditional multicellularity in a wide variety of forms.

192 The emergence of multicellularity in Animalia is associated with increase

193 The evolution of multicellularity in animals required the production of e

194 mergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were e

195 ernal" transitions, such as the evolution of multicellularity in animals.

196 ria might also have influenced the origin of multicellularity in animals.

197 ibed quorum-sensing mechanism for triggering multicellularity in Bacillus subtilis.

198 osetta as a model system for studying simple multicellularity in choanoflagellates and provide an exp

199 Inspired by the patterns of multicellularity in choanoflagellates, the closest livin

200 at are possibly critical in the evolution of multicellularity in choanoflagellates.

201 t Class I RNAs were involved in evolution of multicellularity in Dictyostelia.

202 s of the developmental pathway that leads to multicellularity in Dictyostelium.

203 e link between immunity and the emergence of multicellularity in eukaryotes such as animals.

204 nd how they have adapted to the emergence of multicellularity in eukaryotes.

205 CME mechanism during the autonomous rise of multicellularity in eukaryotes.

206 genes may have some relation to the rise of multicellularity in green plants.

207 ly aid our understanding of the evolution of multicellularity in metazoans.

208 to studying mushroom development and complex multicellularity in one of the largest clades of complex

209 table ROP in the ggb mutant not only rescues multicellularity in protonemata but also results in deve

210 en suggested that they evolved together with multicellularity in separate plant and animal lineages.

211 ere, we review the evolution and genetics of multicellularity in several groups of green algae, which

212 h a comparative study, comparing the form of multicellularity in species where groups are clonal (r =

213 (+)], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces cere

214 l resource in understanding the evolution of multicellularity in the fungi.

215 Among the best-studied ETIs is the origin of multicellularity in the green alga Volvox, a model syste

216 showed that it is essential for maintaining multicellularity in the moss Physcomitrium patens.

217 ystem for understanding the genetic basis of multicellularity including the initial formation of coop

218 algae, a eukaryotic lineage that has evolved multicellularity independently from animals, fungi and p

219 Plants and animals evolved multicellularity independently, and it is unknown whethe

220 ants and animals are thought to have evolved multicellularity independently.

221 Multicellularity inherently involves a number of coopera

222 The evolution of multicellularity involved the transformation of a simple

223 The evolution of multicellularity is a critical event that remains incomp

224 The advent of clonal multicellularity is a critical evolutionary milestone, s

225 Multicellularity is a key evolutionary innovation, leadi

226 The development of multicellularity is a key evolutionary transition allowi

227 The transition to multicellularity is a key feature of the Dictyostelium l

228 The evolution of multicellularity is a major evolutionary transition that

229 llularity overlaps with the GOE, and whether multicellularity is associated with significant shifts i

230 cytial filamentous fungi, the acquisition of multicellularity is associated with somatic cell fusion

231 An obvious requirement for successful multicellularity is communication between different part

232 Together, these data show that rudimentary multicellularity is deeply rooted in the Ascomycota.

233 Their complex multicellularity is inconsistent with a phylogenetic aff

234 Multicellularity is key to the functional and ecological

235 te picture of how signaling pathways lead to multicellularity is largely unknown.

236 Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba

237 A key step in the evolutionary transition to multicellularity is the origin of multicellular groups a

238 Despite the prevalence of surface-associated multicellularity, little is known about its evolutionary

239 Here, using our ongoing Multicellularity Long Term Evolution Experiment (MuLTEE)

240 lar basis of multicellular adaptation in the multicellularity long-term evolution experiment (MuLTEE)

241 Here we investigate this with a multicellularity long-term evolution experiment, selecti

242 This ability to shift between uni- and multicellularity makes the group ideal for studying the

243 y and frequently, the selective advantage of multicellularity may be large.

244 s, the organizational principles of metazoan multicellularity may be more ancient than previously rec

245 The origin of animal multicellularity may be reconstructed by comparing anima

246 ansduction complexes and that coevolved with multicellularity, may represent important EV regulators.

247 elated to halogen metabolism, oxylipins, and multicellularity (microRNA processing and transcription

248 l-autonomous functions and genes involved in multicellularity obey distinct codon usage.

249 Innovations that enabled complex multicellularity occurred through new genes in these pat

250 and themselves play an important role in the multicellularity of P. patens.

251 n ccs52A1 mutations dramatically enhance the multicellularity of sim mutants trichomes in double muta

252 However, the multicellularity of the intact islet has stymied specifi

253 s harbor features important in sexuality and multicellularity once believed to have originated in met

254 The evolution of complex multicellularity opened paths to increased morphological

255 rvival in response to the stress by evolving multicellularity or cell differentiation-or both; howeve

256 ransitions can be recursive (e.g., plastids, multicellularity) or limited (transitions that share the

257 Eukaryotic multicellularity originated in the Mesoproterozoic Era a

258 ferentiation, and a rare occurrence of early multicellularity outside of Konservat-Lagerstatten.

259 We tested whether the evolution of multicellularity overlaps with the GOE, and whether mult

260 the repeated evolution of eukaryotic clonal multicellularity - possibly by first performing a struct

261 peration and competition for the benefits of multicellularity promote the stable coexistence of unice

262 ts possible roles in the evolution of animal multicellularity remains unexplored.

263 ll biology, we reason that the transition to multicellularity required modification of pre-existing m

264 The evolution of multicellularity required novel mechanisms for intercell

265 We conclude that the transition to multicellularity required novel signals and sensors rath

266 Aggregative multicellularity, resulting in formation of a spore-bear

267 omonas reinhardtii to conditions that favour multicellularity, resulting in the evolution of a multic

268 The independent instances of multicellularity reviewed indicate that advantages in fe

269 t energy conservation; this peculiar form of multicellularity seems unparalleled in the microbial wor

270 histories can easily emerge at the origin of multicellularity, shaped by ancestral constraints and ec

271 alization) is a hallmark of the evolution of multicellularity, signifying the emergence of a new type

272 may constitute a barrier to the evolution of multicellularity since cell differentiation requires sen

273 Multicellularity spans a wide gamut in terms of complexi

274 ty that likely relate to the requirements of multicellularity such as the need to establish faithful

275 s studied than other structural mediators of multicellularity (such as adhesion proteins and extracel

276 tonomous timing allows a trial commitment to multicellularity that external signals could extend.

277 presents a transition from simple to complex multicellularity that is inducible under laboratory cond

278 The transition to multicellularity that launched the evolution of animals

279 an important genomic innovation required for multicellularity that occurred in unicellular ancestors

280 early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation

281 However, as the transition proceeds to multicellularity, the group level trade-offs depart from

282 Although fundamental for plant multicellularity, the molecular events leading to bridge

283 Beyond multicellularity, this finding has similar implications

284 isiae to an environment in which we expected multicellularity to be adaptive.

285 mechanisms evolved during the transition to multicellularity to control fundamental cellular process

286 to diverse biological phenomena ranging from multicellularity to mutualism.

287 Here we report the evolution of multicellularity via two distinct mechanisms of group fo

288 in normal tissues, the evolution of complex multicellularity was not accompanied by reductions in mu

289 Development of multicellularity was one of the major transitions in evo

290 Multicellularity was one of the most significant innovat

291 Small-molecule-induced multicellularity was prevented by the addition of potass

292 It has been a decade since multicellularity was proposed as a general bacterial tra

293 hanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome o

294 ary and functional associations with complex multicellularity, which allowed us to speculate they are

295 morphogenesis predating the origin of animal multicellularity, which was co-opted during evolution to

296 , reproductive division of labor, and clonal multicellularity while maintaining sufficient generality

297 We investigate the evolution of multicellularity with an evolutionary model where cells

298 g between cells accompanies the evolution of multicellularity with cell differentiation.

299 gy uses engineering approaches to understand multicellularity with goals ranging from recapitulating

300 eukaryotic lineages to have evolved complex multicellularity, yet despite their ecological, evolutio