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1 to amplify a species-specific region of the multicopy 18S rRNA gene, and SYBR Green was used for det
2 dependent lines of transgenic mice bearing a multicopy 413-kbp-linked Gata2 BAC transgene (bearing se
3 tation of maize carrying a tandemly repeated multicopy allele of pericarp color1 (p1) was examined us
6 y by combining FISH with immunofluorescence; multicopy and repetitive element expression can also be
8 ss mammalian genomes, whereas most genes are multicopy and/or have lineage-specific distributions for
9 RNA gene (SL RNA) repeat is present in large multicopy arrays and has been used as a marker for the d
13 ates independent of copy number variation in multicopy ChrY gene families that influence susceptibili
15 ify novel mutator effects resulting from the multicopy cloning (MCC) of specific genes and therefore
17 ) strand and a heavy (H) strand, exists as a multicopy closed circular genome within the mitochondria
19 range from 28 to 348 bp, and the lengths of multicopy CREE appear mainly in the ranges of 154 to 156
20 ies demonstrated that deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mex
21 ive to QseBC was mapped, and single-copy and multicopy deletion analyses were performed to determine
23 yed octapeptides and avidity effect of their multicopy display on the phage scaffold, good biocompati
25 -Asp-pThr-Asp motifs, recently identified as multicopy docking sites within Mdc1, are evolutionarily
26 s tended to be differentially expressed, and multicopy duplicate genes were likely to diverge express
28 t to (i) complementation; (ii) dominance and multicopy effects; (iii) interaction with wild-type FliH
31 on of enrichment for repetitive and abundant multicopy elements reveals 70% of RBPs have enrichment f
32 of the null mutant with the LmGT4 gene on a multicopy episomal expression vector also reverted these
33 atent, with the viral genome persisting as a multicopy episome and expressing only a small subset of
36 ) share the common property of persisting as multicopy episomes in the nuclei of rapidly dividing hos
37 virus (EBV) establishes latent infections as multicopy episomes with complex patterns of viral gene t
38 upon a stable cell line harboring a visible multicopy ER responsive transcription unit and expressin
42 ster carrier Nfu and partially suppressed by multicopy expression of either sufA or nfu, suggesting f
43 This inhibition can be suppressed by the multicopy expression of mex67 suggesting that Mex67p can
47 boratory conditions, but could be induced by multicopy expression of sypG, which encodes a response r
48 biofilm formation and a hyperswarmer, while multicopy expression of this gene promotes sessility.
55 ated Bcl-X(L) transgenic mice that contain a multicopy Flag-tagged mouse Bcl-x(Flag) transgene driven
62 asite Plasmodium falciparum contains several multicopy gene families, including var, rifin, stevor an
69 nia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface gly
72 ntagonists in this conflict are the X-linked multicopy gene Xmr and its multicopy MSYq-linked relativ
75 entical X chromosome and CNV in Y chromosome multicopy genes exhibit sperm head abnormalities and fem
76 genome stability and organelle function and multicopy genes in signaling, transport, and metabolism.
77 test the hypothesis that CNV in Y chromosome multicopy genes influences the paternal parent-of-origin
79 an and mouse sex chromosomes are enriched in multicopy genes required for postmeiotic differentiation
88 as a low copy number in elasmobranchs but is multicopy in the holocephalan spotted ratfish (Hydrolagu
89 ously published M. tuberculosis strains with multicopy inhA or kasAB plasmids, were tested for their
90 rtussis, and B. holmesii was developed using multicopy insertion sequences (ISs) in combination with
92 lating cells, which may obviate the need for multicopy integration to achieve high-level expression a
93 t host and thus bypasses the requirement for multicopy Kan(r); faa and ssrA mutants are additive in t
94 NA (tmRNA) (encoded by ssrA), coupled with a multicopy kanamycin resistance determinant, suppressed b
95 nii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein
97 ocumented, are also unusual in their lack of multicopy LINE-like and gypsy-like retrotransposons, gro
99 point of view, our results suggest that the multicopy MD simulation approach is very useful when stu
104 Synonymous substitution rate analyses of the multicopy MSY genes indicated that two major periods of
105 are the X-linked multicopy gene Xmr and its multicopy MSYq-linked relative Sly, which are upregulate
106 regulatory mechanism controlling dispersed, multicopy MuDR/Mu elements responsible for Mutator activ
110 host suppression of 2-micron (2mu) plasmids, multicopy nuclear parasites that have co-evolved with bu
112 ry components of the ribosome are encoded by multicopy nuclear ribosomal RNA (rRNA) genes: 28/26S, 18
116 e hyperfimbriated phenotype conferred by the multicopy oxyR plasmid was absent in a type I fimbrial m
118 ion and small RNA targeting, relating to the multicopy paralogous genes generated from whole genome t
119 hed at centromeres, TET/JBP transposons, and multicopy paralogous genes that are not expressed, but r
122 Second, in medium that lacked thymidine, multicopy phtC(+) or phtD(+) alleles enhanced the surviv
124 treated with dihydroartemisinin-piperaquine, multicopy plasmepsin 2 in the sample collected before tr
126 l and temporal increase of the proportion of multicopy plasmepsin 2 parasites was highly correlated w
129 mutation in acrR or acrAB expression from a multicopy plasmid also suppressed the TolCP246R,S350C de
131 onsequences of overexpression of tnaC from a multicopy plasmid and observed that under inducing condi
132 the C-terminal 53 amino acids of MutS) on a multicopy plasmid are proficient for mutation avoidance.
133 nhibited by an oversupply of DnaA and that a multicopy plasmid carrying rcbA neutralizes this inhibit
134 eplication and distribution of the bacterial multicopy plasmid ColE1 in a population of exponentially
140 igen gene promoter or in a strain carrying a multicopy plasmid containing the entire B. cereus plc-sp
141 in place of WT ftsA or with ftsA* alone on a multicopy plasmid divide mostly normally, whether they a
142 hromosomal DeltaacrB mutant transformed with multicopy plasmid encoding MdtM suggested a functional s
144 outer membrane phospholipase gene pldA on a multicopy plasmid in a vpsC or vacJ mutant restored its
147 type strain, while expression of YggX from a multicopy plasmid increased the aconitase levels above t
148 NAIII in trans to the MW2 arlRS mutant via a multicopy plasmid induced autolysis in this MRSA strain.
150 We demonstrate that DksA expression from a multicopy plasmid is necessary and sufficient for suppre
151 f the CCU/CCA/CCG-decoding tRNA(Pr)(o)3 on a multicopy plasmid leads to suppression of several +1 fra
154 expressed either from the trc promoter on a multicopy plasmid or from the endogenous dsbA promoter b
156 e its role further, comW was cloned into the multicopy plasmid pMSP3535, under the control of a nisin
157 When induced for expression, baeR cloned in multicopy plasmid pTrc99A significantly increased the re
158 d over-expression of the DinG protein from a multicopy plasmid result in a slight reduction of UV res
160 partitioning locus STB of the 2mum circle--a multicopy plasmid that resides in the yeast nucleus and
161 ains containing the B. cereus plcR gene on a multicopy plasmid under control of the strong B. anthrac
162 fragments between 3 and 5 kbp in length on a multicopy plasmid vector that was transformed into E. co
163 ontaining the intact groES-groEL operon on a multicopy plasmid was generated and used to demonstrate
164 some of the TBP mutations is suppressed by a multicopy plasmid with SNR6 or by an spt3 mutation.
166 ntify the genes which, when expressed from a multicopy plasmid, can restore the growth defect of the
168 erhelicase mutant, and when expressed from a multicopy plasmid, it results in UV sensitivity (UV(s)),
169 When each of the genes was expressed from a multicopy plasmid, M. smegmatis exported comparable prop
171 1 gene and/or the mobN1 gene was cloned on a multicopy plasmid, production of the protein was constit
172 product, when either mutated or cloned on a multicopy plasmid, seems to be capable of compensating f
182 lly constitutive not only when produced from multicopy plasmids but also at a single-copy gene dosage
187 While the expression of these proteins on multicopy plasmids did not improve production over the b
190 mltG was initially isolated in a screen for multicopy plasmids generating a lethal phenotype in cell
192 harvesting complex components expressed from multicopy plasmids in strains in which the corresponding
193 o- to four-times-higher values obtained from multicopy plasmids in stringent cells and eight-times-hi
196 lso monitored the effects of the presence of multicopy plasmids on the position of DNA polymerase usi
198 strong inducer dependence when produced from multicopy plasmids, B. bronchiseptica B013N alcR partial
201 n: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid
203 to test E. coli strains, both in the form of multicopy recombinant plasmids and as lysogenized propha
207 lines of evidence that a eutherian-specific multicopy retrogene, DUX4, encodes a transcription facto
208 ared origin of the two resistance-conferring multicopy Rhg1 groups and subsequent independent evoluti
209 find that SCN resistance is associated with multicopy Rhg1 haplotypes that form two distinct groups.
212 t detail, the functional organization of the multicopy rRNA gene clusters (rDNA) in the nucleolus is
216 Saccharomyces cerevisiae 2-mum plasmid is a multicopy selfish genome that resides in the nucleus.
217 great ape common ancestor already possessed multicopy sequences homologous to most human and chimpan
218 cular type of error in the reference genome: multicopy sequences which have been incorrectly assemble
232 rowth with pyruvate as the carbon source and multicopy suppression suggest that several other transam
233 ty is typically studied experimentally using multicopy suppression, in which over-expression of a pro
235 Proteus mirabilis, tatA was identified as a multicopy suppressor and restored extracellular signal p
239 Escherichia coli, is known to function as a multicopy suppressor for dnaJ mutations and to bind nons
240 e recently observed that KsgA functions as a multicopy suppressor for the cold-sensitive cell growth
242 RbfA, a 30S ribosome-binding factor, is a multicopy suppressor of a cold-sensitive C23U mutation o
243 encodes a putative Hsp90 co-chaperone, as a multicopy suppressor of a temperature-sensitive allele (
245 ste 12 (Su(z)12), Extra Sex Combs (ESC), and Multicopy Suppressor of IRA 1 (MSI1), and functions in m
248 The transcription factors Msn2 and Msn4 (multicopy suppressor of SNF1 mutation proteins 2 and 4)
250 We isolated a novel gene, alp16(+), as a multicopy suppressor of temperature-sensitive alp6-719 m
251 des C, C, and A to the 3' end of tRNAs, is a multicopy suppressor of the defect in tRNA nuclear expor
253 e identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13-117 (cy
254 NA processing and degradation pathways, is a multicopy suppressor of the synthetic lethality and of t
256 ified the ribosome binding protein Stm1 as a multicopy suppressor of the temperature sensitivity of t
258 ized open reading frame YER074W-A as a novel multicopy suppressor of the thermosensitive yip1-4 strai
264 ial proteins (e.g. MTCO3) were identified as multicopy suppressors of cdc13-1, suggesting the involve
265 gh three independent genome-wide screens for multicopy suppressors of each of the three Vpr activitie
266 We have identified OXA1 and TIM17 as novel multicopy suppressors of mtDNA instability in ilv5 cells
268 otential targets for Cln3/CDK, we identified multicopy suppressors of the temperature sensitivity of
269 dentify functional partners, we screened for multicopy suppressors of the temperature-sensitive ydj1-
272 re we identify several HAL genes that act as multicopy suppressors of this sensitivity and are connec
273 ia coli porin regulation was discovered from multicopy suppressors that permitted growth of cells exp
276 rDNA) genes in eukaryotes are organized into multicopy tandem arrays and transcribed by RNA polymeras
277 genomes by inserting site-specifically into multicopy target sites, thereby avoiding random disrupti
278 oth the deletion and/or the transposition of multicopy TEs associated with 2b-induced hypomethylation
281 SID-1 is required for efficient silencing of multicopy transgenes, indicating that mobile silencing s
287 te that mutation of Rnu2-8, one of the mouse multicopy U2 snRNA genes, causes ataxia and neurodegener
293 d vast diversity of its highly antigenic and multicopy var genes preclude such clear clustering in en
294 hese B. anthracis Spo0E-like proteins from a multicopy vector consistently resulted in a sporulation-
297 en eis was introduced into M. smegmatis on a multicopy vector, sodium dodecyl sulfate-polyacrylamide
300 oform derived from an internal promoter in a multicopy YAC transgenic line results in a microphthalmi