ライフサイエンスコーパス: multidomain

1 EI is a multidomain, 128-kDa homodimer that has been shown to ex

2 cated maturation machinery including HydF, a multidomain [4Fe4S] cluster protein with GTPase activity

3 RIM-binding proteins (RIM-BPs) are multidomain active zone proteins that bind to RIMs and t

4 Fe65 is a multidomain adaptor with established functions in neuron

5 oward the structural modeling of metastable, multidomain aggregation intermediates.

6 tyrosine kinases of the Src family are large multidomain allosteric proteins that are crucial to cell

7 The Multidomain Alzheimer Preventive Trial was a 3-year, mul

8 This experiment has enabled a careful multidomain analysis of a controlled perturbation of the

9 UGGT substrates identified were mainly large multidomain and heavily glycosylated proteins when compa

10 of current structural biology, which include multidomain and intrinsically disordered proteins as wel

11 generalize this model to analyze engineered multidomain antibodies, where components of different an

12 We sought to evaluate the utility of a multidomain approach incorporating symptoms, lung functi

13 n homology and thus don't mirror the complex multidomain architecture and the shuffling of functional

14 CshA possesses a distinctive multidomain architecture comprising an N-terminal target

15 cations and underscore the importance of the multidomain architecture in translation factors to sense

16 hat ncRNAs, like many large proteins, have a multidomain architecture that organizes them spatially a

17 It is thought that Dicer uses its multidomain architecture to calibrate RNA product length

18 netic tree whose topology suggested that the multidomain architecture was inherited from bacterial an

19 ses produce diverse natural products using a multidomain architecture where the growing peptide, atta

20 ct subcellular compartments because of their multidomain architecture.

21 A, B, E, F, and G and demonstrate that their multidomain architectures reflect their phylogenetic rel

22 Because of their size and often elaborate multidomain architectures, these polypeptides represent

23 We developed MULTIDOMAIN ASSEMBLER (MDA) to address the special probl

24 This 2,366-amino-acid, multidomain bacterial toxin glucosylates and inactivates

25 BOK, a multidomain BCL-2 family protein, is generally believed

26 ity of 14-3-3 to modulate the structure of a multidomain binding partner and to function as an allost

27 The multidomain calcium-binding betagamma-crystallin protein

28 We find that up to 1% of all identified multidomain calcium-binding proteins contain a similarly

29 The multidomain CCCTC-binding factor (CTCF), containing a ta

30 EUR_21100 is a multidomain cell wall anchored amylase that preferential

31 A multidomain chloroplast-specific subunit of the SRP, cpS

32 importance of flexible linkers in regulating multidomain chromatin binding proteins and point to dive

33 all CpG-dense promoters are occupied by the multidomain chromosomal protein FBXL10.

34 DP ribosylation factor-binding protein 3), a multidomain clathrin adaptor protein that sorts cargo pr

35 at the in planta mature form of proGrCLE1, a multidomain CLE effector secreted by PCN during infectio

36 Our finding also provides evidence that multidomain CLEs are modified and processed similarly to

37 r Cdc37 and forms stable complexes through a multidomain cochaperone interface.

38 gest that either the left FTP is involved in multidomain cognitive control or that there are multiple

39 ical response, which can be applied to other multidomain complexes.

40 e dehydrogenase complex (PDC) comprises four multidomain components, E1, E3, E2 and an E3-binding pro

41 Measurement of a multidomain construct indicates that the solution bindin

42 d electron micrographs of the ectodomain and multidomain constructs, we have determined the structura

43 er and EF-hand domain protein 1 (ZZEF1) is a multidomain-containing protein.

44 Here, we obtain a multidomain-corrected Pliocene-Pleistocene average paleo

45 nterface mediated by N3A-N3A' motifs defines multidomain cross-talk and an allosteric network that cr

46 Histone deacetylase 6 (HDAC6) is a multidomain cytosolic enzyme having tubulin deacetylase

47 l methods for high-dimensional, longitudinal multidomain data that provide greater interpretability t

48 These new longitudinal multidomain data were analyzed using recently developed

49 For the large, multidomain DEBS1, substantial premature termination of

50 nt in force spectroscopy, and for the large, multidomain dimeric protein von Willebrand factor (VWF)

51 ynein-like core with six ATPase units, and a multidomain E3 module.

52 and catalytic function are correlated in the multidomain Ec ProRS, an enzyme that is central to prote

53 the complete deletion (or overexpression) of multidomain-encoding genes or combinations of genes and

54 paradigm for improving our understanding of multidomain enzyme function.

55 mediated silencing of GPD2 revealed that the multidomain enzyme was required for TAG accumulation und

56 nd up-regulation of a gene, GPD2, encoding a multidomain enzyme with a putative phosphoserine phospha

57 ADAMTS-5 is a multidomain enzyme, but the function of the C-terminal a

58 Ec ProRS is a multidomain enzyme; coupled-domain dynamics are essentia

59 few decades, a view has emerged showing that multidomain enzymes are biological machines evolved to h

60 olecule Interacting with CasL) are conserved multidomain enzymes essential for cytoskeletal reorganiz

61 uctase and phosphatase activities of PSP-GPD multidomain enzymes may be modulated by post-translation

62 tive polyketide synthases (IPKSs), which are multidomain enzymes noted for generating diverse small m

63 NOSs are homodimeric multidomain enzymes responsible for producing NO.

64 l peptide synthetases (NRPSs) comprise giant multidomain enzymes responsible for the "assembly line"

65 nreducing polyketide synthases (NR-PKSs) are multidomain enzymes responsible for the construction of

66 As multidomain enzymes, they contain an N-terminal ubiquiti

67 A multidomain evaluation of systemic steroid responsivenes

68 om the ATP-binding cassette transporters and multidomain extracellular and S-layer-associated glycosi

69 muscle-secreted scaffolding protein LEV-9, a multidomain factor containing complement control protein

70 rt negative capacitance in a model system of multidomain ferroelectric-dielectric superlattices acros

71 and electrical characterizations along with multidomain finite-element analysis simulation.

72 e enhanced electron scattering from magnetic multidomains formed around the first-order orbital-flop

73 The NR-PKSs were dissected into mono- to multidomain fragments and recombined as noncognate pairs

74 A simple approach to a patterned multidomain gel is reported, combining a pH-responsive l

75 etwork; we define the resulting system as a "multidomain gel"-one domain consists of a LMWG, whereas

76 ing this approach with a mask during step b, multidomain gels are formed, in which the network based

77 Reconcilibacillus cellulovorans' multidomain GHs assembled into cellulase complexes throu

78 Blood loss is prevented by the multidomain glycoprotein von Willebrand factor (VWF), wh

79 vorans', possessed a gene cluster containing multidomain glycoside hydrolases (GHs).

80 eckstrin homology (PH) domain 1 (ASAP1) is a multidomain GTPase-activating protein (GAP) for ADP-ribo

81 Dynamins are a family of large, multidomain GTPases involved in key cellular processes i

82 DOCK (dedicator of cytokinesis) proteins are multidomain guanine nucleotide exchange factors (GEFs) f

83 eleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs

84 el to be combined with configurations of the multidomain Hck kinase previously determined from small-

85 Human peroxidasin 1 (hsPxd01) is a multidomain heme peroxidase that uses bromide as a cofac

86 main adjacent to zinc finger 2B (BAZ2B) is a multidomain histone-binding protein that contains two hi

87 PAH is a multidomain homo-multimeric protein whose conformation a

88 P of varphi11, which assembles into a large, multidomain homotrimer.

89 These unique properties are compatible with multidomain imaging in giant unilamellar vesicles (GUVs)

90 The second type consists of multidomain inhibitors which evolved by intragenic dupli

91 r binding, the structure and topology of the multidomain interacting partners, and the valency of eac

92 RM1, suggesting that SARM1 function requires multidomain interactions.

93 re randomly assigned (1:1:1:1) to either the multidomain intervention (43 group sessions integrating

94 unsaturated fatty acid supplementation and a multidomain intervention (physical activity, cognitive t

95 INTERPRETATION: The multidomain intervention and polyunsaturated fatty acids

96 lacebo assignment, but were unblinded to the multidomain intervention component.

97 Low-strength evidence showed that a multidomain intervention comprising physical activity, d

98 roup, 0.079 (-0.012 to 0.170; 0.179) for the multidomain intervention plus placebo group, and 0.011 (

99 acid and 225 mg eicosapentaenoic acid), the multidomain intervention plus placebo, omega 3 polyunsat

100 A multidomain intervention showed a delay in cognitive dec

101 An effective multidomain intervention strategy to prevent or delay co

102 ults may suggest potential pathways by which multidomain interventions might help delay AD onset or p

103 urrently, the best management strategies are multidomain interventions that focus on treating precipi

104 in ongoing trials include the development of multidomain interventions, and the use of biomarker or g

105 on-collinear antiferromagnetic structure and multidomain Jahn-Teller distortions, likely related to i

106 omplexed to a drug-sensitized variant of the multidomain kinase Src.

107 Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein

108 teractions in conformational dynamics at the multidomain level.

109 Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions.

110 m as large single-domain architectures or as multidomain materials.

111 Multidomain (MD) magnetite may also be present in all sa

112 nsmembrane conductance regulator (CFTR) is a multidomain membrane protein that functions as a phospho

113 Such studies are challenging regarding multidomain membrane proteins like CusS and also lack th

114 li alpha2M (ECAM) is a approximately 180-kDa multidomain membrane-anchored pan-peptidase inhibitor, w

115 ng, visualization, and selection followed by multidomain model generation, and is part of the widely

116 Each of its six multidomain modules presumably sample distinct conformat

117 UNC-45B is a multidomain molecular chaperone that is essential for th

118 nnovative approach yields spatially resolved multidomain multicomponent gels based on programmable lo

119 Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in t

120 peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structu

121 y important natural products are produced by multidomain non-ribosomal peptide synthetases (NRPSs).

122 During synthesis, the multidomain NRPSs act as an assembly line, passing the g

123 vide insights into the nanomechanics of such multidomain or heteromeric proteins.

124 t ATP7B remains limited because of a complex multidomain organization of the protein.

125 a compact overall architecture with a tight, multidomain organization.

126 -spot diameter and quantitative imaging of a multidomain Pallasite meteorite at a 10 mum LA-spot size

127 NOD2 encodes an intracellular multidomain pattern recognition receptor that is the str

128 ro studies described the biocompatibility of multidomain peptide (MDP) hydrogel scaffolds with dental

129 dependent on the amino acid sequence of the multidomain peptide.

130 is work, we expand our ability to manipulate multidomain-peptide assembly into parallel-aligned fiber

131 Self-assembly of multidomain peptides (MDP) can be tailored to carry payl

132 Multidomain peptides are one such assembler, and in prev

133 subtilis PdaC (BsPdaC) is a membrane-bound, multidomain peptidoglycan N-deacetylase acting on N-acet

134 Human peroxidasin 1 is a homotrimeric multidomain peroxidase that is secreted to the extracell

135 es, suggesting a conceptual link among these multidomain, phosphoryl transfer enzymes.

136 Phytochromes are multidomain photoswitches that drive light perception in

137 e analysis of two conformational states of a multidomain pLGIC, called DeCLIC, from a Desulfofustis d

138 ent-related deaths were recorded (two in the multidomain plus placebo group and two in the placebo gr

139 aturated fatty acids group, 142 (34%) in the multidomain plus placebo group, 134 (33%) in the polyuns

140 146 (36%) participants in the multidomain plus polyunsaturated fatty acids group, 142

141 The multidomain polymerase protein (L) of nonsegmented negat

142 -like PUFA synthase system, comprising three multidomain polypeptides and an accessory enzyme, in can

143 The multidomain pro-apoptotic Bcl-2 family proteins BAK and

144 L-2 family protein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok(-

145 INTERPRETATION: The multidomain progression measure in TRACK-HD was associat

146 WFIKKN1, a multidomain protease inhibitor that binds growth factors

147 y structure and the inhibitory activity of a multidomain protease inhibitor.

148 the pressure-induced destabilization of this multidomain protein by using solution NMR spectroscopy.

149 oenzyme A carboxylase to plastids, where the multidomain protein can participate in fatty acid biosyn

150 he endoplasmic reticulum to the Golgi by the multidomain protein ceramide transfer protein (CERT).

151 P1 is a large (185-kDa) and complex multidomain protein considered a promising target antige

152 ine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a

153 UHRF1 is a multidomain protein crucially linking histone H3 modific

154 gic studies exemplify a general strategy for multidomain protein drug-target validation and in case o

155 Neurofibromin is a multidomain protein encoded by the NF1 gene, the mutatio

156 However, multidomain protein folding and the energetics of domain

157 functions of domain interactions involved in multidomain protein folding have been obscure.

158 Multidomain protein folding is often more complex than a

159 However, it is also known that some multidomain protein folds exhibit no evidence for misfol

160 OmpA is a multidomain protein found in the outer membranes of most

161 e the power of SMACKS on the kinetics of the multidomain protein Hsp90 measured by single-molecule Fo

162 SasG, a multidomain protein implicated in host colonization and

163 Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein implicated in Parkinson disease (PD)

164 lopmental endothelial locus-1) is a secreted multidomain protein interacting with integrins and phosp

165 lum (ER) stress levels, the ER transmembrane multidomain protein IRE1alpha promotes either adaptation

166 orthogonally tag or label a domain within a multidomain protein may be complicated by undesirable si

167 The core component of MECA is the multidomain protein Num1, which assembles into clusters

168 The adenylate cyclase (CyaA) toxin, a multidomain protein of 1706 amino acids, is one of the m

169 We show that the multidomain protein PelB with a predicted C-terminal bet

170 ng separate domains into a single functional multidomain protein reported here may enable many applic

171 m coordinates Ras and Rac activity using the multidomain protein RGBARG (RCC1, RhoGEF, BAR, and RasGA

172 Fibronectin is a multidomain protein secreted by various cell types.

173 mplex relationship among missense mutations, multidomain protein stability, and disease phenotypes in

174 AhpF is a flexible multidomain protein that enables a series of electron tr

175 HIV-1 Gag is a highly flexible multidomain protein that forms the protein lattice of th

176 It is a multidomain protein that integrates readout of different

177 g pathways of the human gammaD-crystallin, a multidomain protein that must remain correctly folded du

178 nctional ~310 kDa ectodomain of VAR2CSA is a multidomain protein that requires a minimum 12-mer chond

179 protein from Saccharomyces cerevisiae, is a multidomain protein that specifically binds telomeric si

180 Human fatty acid synthase (FAS) is a large, multidomain protein that synthesizes long chain fatty ac

181 brane-binding domain of CARMIL2 tethers this multidomain protein to the membrane, where it links dyna

182 ata informs the first detailed mechanism for multidomain protein unfolding in the gas phase, and high

183 ine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and G

184 o assembling this protein complex is CcmM, a multidomain protein whose C-terminal region is required

185 cine-rich repeat kinase 2 (LRRK2) is a large multidomain protein with both a Ras of complex (ROC) dom

186 GCN2 is a multidomain protein with key regulatory domains that dir

187 Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegri

188 s an example, this probe was used in a large multidomain protein with ten identical ankyrin repeats,

189 ing the structure-function relationship of a multidomain protein with weak domain-domain interactions

190 nal analysis of the single subunits within a multidomain protein, achieved without the necessity to e

191 cine-rich repeat kinase 2 (LRRK2) is a large multidomain protein, and LRRK2 mutants are recognized ri

192 leic acid (DNA) are concentrated in a single multidomain protein, Cas9, and are guided by a co-proces

193 Loss of sacsin, a large 520 kDa multidomain protein, causes autosomal recessive spastic

194 Evidence is presented that the multidomain protein, HypX, converts the formyl group of

195 t of the folding pathway for the model large multidomain protein, Luciferase, by combining single-mol

196 everal functional sites in an oligomeric and multidomain protein.

197 ction, complicates the folding of this large multidomain protein.

198 p85 subunit of class I PI3K and is a large, multidomain protein.

199 Multidomain proteins account for 70% of the eukaryotic p

200 combination of repression and activation in multidomain proteins allowing for fine tuning of regulat

201 escribed here may be common to several other multidomain proteins and allosteric systems.

202 ating the catalytic mechanisms of individual multidomain proteins and protein domains within these me

203 In genetic disease, multidomain proteins are often affected by numerous muta

204 provides some unifying principles as to how multidomain proteins assemble biological polymers.

205 t a knot-induced stall during degradation of multidomain proteins by AAA proteases may constitute a n

206 h to describing conformational equilibria of multidomain proteins can be further combined with other

207 Multidomain proteins complicate the protein sequence-str

208 Many multidomain proteins contain disordered linkers that reg

209 nance energy transfer (FRET) have shown that multidomain proteins containing tandem repeats may form

210 The way in which multidomain proteins fold has been a puzzling question f

211 solving the conformational dynamics of large multidomain proteins has proven to be a significant chal

212 he folding behaviors and mechanisms of large multidomain proteins have remained largely uncharacteriz

213 ow genetic mutations affect the stability of multidomain proteins in inherited disease.

214 lly and experimentally, the folding of large multidomain proteins is less well known.

215 nd understanding of the folding mechanism of multidomain proteins is still a challenge in structural

216 lity of the Saccharomyces cerevisiae NPC for multidomain proteins of different sizes and found that s

217 g proteins (RBPs) are evolutionary conserved multidomain proteins of presynaptic active zones that ar

218 The functional mechanisms of multidomain proteins often exploit interdomain interacti

219 ometry (CSOP), to quantify the height of key multidomain proteins on a model cell, as well as to capt

220 Although multidomain proteins predominate the proteome of all org

221 ffector modules consisting of single, large, multidomain proteins that appear to have been derived fr

222 Formins are multidomain proteins that assemble actin in a wide varie

223 accessory proteins (EAPs), many of which are multidomain proteins that encode a wide range of biochem

224 control nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in retrov

225 about folding mechanisms of medium and large multidomain proteins that predominate the proteomes of a

226 CARMILs are large multidomain proteins that regulate the actin-binding act

227 , we can reproduce the known propensities of multidomain proteins to form domain-swapped misfolds, wh

228 otal, 291 domain atomic structures from nine multidomain proteins were modeled by homology, equilibra

229 llustrated through the traceless assembly of multidomain proteins whose biophysical properties render

230 Neighbouring domains of multidomain proteins with homologous tandem repeats have

231 the study of intramolecular interactions in multidomain proteins with intrinsically disordered regio

232 bilizing interactions between the domains of multidomain proteins, and provide insights into the nano

233 more than 75% of the proteome is composed of multidomain proteins, current knowledge of protein foldi

234 TcdA and TcdB are large, multidomain proteins, each harboring a cytotoxic glucosy

235 resolution, studies of structurally complex multidomain proteins, folding in the presence of chapero

236 e complex folding and unfolding mechanism of multidomain proteins, it is necessary to monitor multipl

237 es may enable joining of single domains into multidomain proteins, lipidation to mimic posttranslatio

238 Compared to other multidomain proteins, these motions are rather fast and

239 ch in assigning functions of uncharacterized multidomain proteins, which can potentially aid function

240 how small proteins fold, research on larger, multidomain proteins, which comprise the majority of pro

241 actions with DBDs.Nuclear receptors (NR) are multidomain proteins, which makes their crystallization

242 s that are sequence-related to larger, often multidomain proteins.

243 elusive for most proteins, especially large, multidomain proteins.

244 odulate the function of structurally similar multidomain proteins.

245 aspects of conformational dynamics in large multidomain proteins.

246 propensity for domain-swapped misfolding of multidomain proteins.

247 rs to characterizing the domain structure of multidomain proteins.

248 y 60 members) of P. falciparum EMP1 (PfEMP1) multidomain proteins.

249 teraction motifs or as structural spacers in multidomain proteins.

250 main communications are likely important for multidomain proteins.

251 determine the structural properties of these multidomain proteins.

252 y be particularly relevant to the folding of multidomain proteins.

253 racterize the conformational fluctuations of multidomain proteins.

254 en occurs in the context of other domains in multidomain proteins.

255 he multiple signaling states of these large, multidomain proteins.

256 provides a physical basis for the origin of multidomain proteins.

257 ding disorder-based allosteric regulation in multidomain proteins.

258 nal neuroimaging study of the human brain, a multidomain protocol was utilized to investigate the rol

259 synthase, the enzyme involved, is an unusual multidomain radical SAM enzyme that uses two separate 5'

260 ered linkers to modulate RNA interactions of multidomain RBPs.

261 Thrombomodulin is a multidomain receptor primarily expressed by vascular end

262 plication complexes in infected cells from a multidomain replication polyprotein.

263 (2+) binding triggers an increase in protein multidomain rigidity, reducing conformational flexibilit

264 , removing barriers to adherence, mitigating multidomain risks, augmenting self-management, and creat

265 NA viruses, such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both

266 k employs live cell imaging to probe how the multidomain scaffold IQ motif containing GTPase activati

267 Here we identify the endocytic multidomain scaffold protein intersectin as an important

268 Shank3 is a multidomain scaffold protein localized to the postsynapt

269 t of effective pharmacological inhibitors of multidomain scaffold proteins, notably transcription fac

270 We propose that Abl acts as a robust multidomain scaffold with different protein motifs and a

271 The multidomain scaffolding protein intersectin 1 (ITSN1) is

272 sequestosome 1; also known as p62) encodes a multidomain scaffolding protein involved in various key

273 CD2-associated protein (CD2AP) is a multidomain scaffolding protein that has a critical role

274 NBEAL2 encodes a multidomain scaffolding protein with a putative role in

275 Multidomain scaffolding proteins nucleate assembly and d

276 action phosphatases and kinases complex, are multidomain scaffolding proteins that play important bio

277 is coupling often depends on the function of multidomain scaffolds that orchestrate transient interac

278 ntra- and intermolecular interactions in the multidomain signaling protein, protein kinase Calpha (PK

279 CARD11 is a multidomain signaling scaffold protein required for anti

280 These multidomain signatures provided experimental support for

281 etabolomics enabled the characterization of "multidomain signatures", or functional readouts of NRPS-

282 otein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to th

283 mine the conformational space sampled by the multidomain splicing factor U2AF65 using complementary n

284 Their multidomain structure and autocatalytic incorporation of

285 dy because of their low level of expression, multidomain structure, and complex molecular dynamics th

286 proteins are defined by their stereotypical multidomain structure: an N-terminal Toll-interleukin re

287 single-molecule degradation using different multidomain substrates and ClpXP variants, we answer man

288 codes an ortholog of BPTF, a large (>300 kD) multidomain subunit of the NURF chromatin remodeling com

289 work, we describe the folding mechanism of a multidomain tandem construct comprising two distinct cov

290 The multidomain toxins enter cells by receptor-mediated endo

291 ptoms stem from the activities of two large, multidomain toxins known as TcdA and TcdB.

292 ns 1 and 2 (APLP1 and APLP2) are a family of multidomain transmembrane proteins possessing homo- and

293 pe II secretion of VesB, the first bacterial multidomain trypsin-like protease with known structure,

294 actin recruiting phosphoprotein (Tarp) is a multidomain type III secreted effector used by Chlamydia

295 Janus kinases (JAKs) are receptor-associated multidomain tyrosine kinases that act downstream of many

296 Sm1 encodes a multidomain UDP-rhamnose synthase (RHS1) that converts U

297 the folding and DNA-binding processes of the multidomain Y-family DNA polymerase IV (DPO4).

298 The multidomain zinc finger (ZnF) protein PRDM9 (PRD1-BF1-RI

299 RREB1 is a large, complex gene which codes a multidomain zinc finger binding protein and transcriptio

300 Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes