ライフサイエンスコーパス: multidrug resistance protein

1 resistance proteins, P-glycoprotein and MRP (multidrug resistance protein).

2 23/R resistant cell line which overexpresses multidrug resistance protein.

3 ne that do not overexpress P-glycoprotein or multidrug resistance protein.

4 e transporters such as P glycoprotein or the multidrug resistance protein.

5 hout overexpression of P-glycoprotein or the multidrug resistance protein.

6 (MOAT), the liver-specific homologue of the multidrug resistance protein.

7 the expression of anti-apoptotic factors and multidrug resistance proteins.

8 ansporter protein with homology to mammalian multidrug resistance proteins.

9 f the intestinal barrier, such as mucins and multidrug resistance proteins.

10 efflux pumps such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cance

11 Upregulation of the multidrug resistance protein 1 (LeMDR1) in the protozoan

12 led to increased expression and activity of multidrug resistance protein 1 (MDR-1), a membrane trans

13 The overexpression of multidrug resistance protein 1 (MDR1) and multidrug resi

14 ociated proteins caveolin-1, syntaxin-6, and multidrug resistance protein 1 (MDR1) in brain endotheli

15 or (PXR) was observed together with ApoE and multidrug resistance protein 1 (MDR1) membrane transport

16 Discovery of the multidrug resistance protein 1 (MDR1), an ATP-binding ca

17 Multidrug resistance protein 1 (MRP1) actively transport

18 To examine the role of multidrug resistance protein 1 (MRP1) and glutathione S-

19 ions, and the role of P-glycoprotein (P-gp), multidrug resistance protein 1 (mrp1) and organic anion

20 histochemical expression of bronchopulmonary multidrug resistance protein 1 (MRP1) and permeability g

21 The multidrug resistance protein 1 (MRP1) contributes cellul

22 The multidrug resistance protein 1 (MRP1) encoded by ABCC1 w

23 of multidrug resistance protein 1 (MDR1) and multidrug resistance protein 1 (MRP1) gene products is a

24 Human multidrug resistance protein 1 (MRP1) is a member of the

25 Multidrug resistance protein 1 (MRP1) is an ABC exporter

26 eans to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemothera

27 The multidrug resistance protein 1 (MRP1), P-glycoprotein, a

28 reports, no consistent relationship between multidrug resistance protein 1 (MRP1, ABCC1) expression

29 ned against P-glycoprotein (P-gp, ABCB1) and multidrug resistance protein 1 (MRP1, ABCC1) to confirm

30 The polytopic 5-domain multidrug resistance protein 1 (MRP1/ABCC1) extrudes a v

31 The ATP-binding cassette (ABC) transporter multidrug resistance protein 1 (MRP1/ABCC1) is responsib

32 uman ATP-binding cassette (ABC) transporter, multidrug resistance protein 1 (MRP1/ABCC1), confers res

33 not for the MDR1 P-glycoprotein (ABCB1/Pgp), multidrug resistance protein 1 (MRP1/ABCC1), or multidru

34 iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).

35 in the prevalences of wild-type P falciparum multidrug resistance protein 1 (PfMDR1) Asn86Tyr from 60

36 as well as favorable PET tracer attributes (multidrug resistance protein 1 efflux, central nervous s

37 mether-lumefantrine are common: P falciparum multidrug resistance protein 1 N86 at 98.0% (range, 63.3

38 her conferred by the classic P-glycoprotein (multidrug resistance protein 1) or by other mechanisms,

39 ne domains but some, including SUR and MRP1 (multidrug resistance protein 1), contain an extra N-term

40 t was found to be actively extruded by MRP1 (multidrug resistance protein 1).

41 mpicin-induced gene expression of CYP3A4 and multidrug resistance protein 1, as well as their respect

42 Low or no induction of multidrug resistance protein 1, multidrug resistance-rel

43 l-time PCR to measure the mRNA expression of multidrug resistance protein 1, multidrug resistance-rel

44 mium resistance by serving as a cofactor for multidrug resistance protein 1/GS-X pump-mediated cadmiu

45 ers breast cancer resistance protein (BCRP), multidrug-resistance protein 1 (MDR1), and multidrug-res

46 ciated protein 2, bile salt export pump, and multidrug-resistance protein 1) dissociated from their n

47 lar cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(

48 Interestingly, multidrug resistance protein-1 (MRP-1) expression, but n

49 und that human endothelial cells express the multidrug resistance protein-1 (MRP1) and use this as th

50 thiol/disulfide balance, greater extents of multidrug resistance protein-1 (MRP1) expression, and gr

51 calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cel

52 4) is transferred to its export carrier, the multidrug resistance protein-1.

53 toplasmic side of the membrane for export by multidrug resistance protein-1.

54 P-glycoprotein (P-gp) and multidrug-resistance protein-1 (MRP-1) are adenosine tri

55 s classified as ABCC2 or Leishmania donovani multidrug resistance protein 2 (LdMRP2).

56 mpared to common bile duct-ligated (BDL) and multidrug resistance protein 2 (Mdr2) KO mice.

57 transport protein 1a and 1b (Oatp1a/1b) and multidrug resistance protein 2 (Mrp2) was investigated b

58 Multidrug resistance protein 2 (MRP2), a marker selectiv

59 In contrast, levels of RNA coding for multidrug resistance protein 2 (MRP2), which transports

60 tidrug resistance protein 1 (MRP1/ABCC1), or multidrug resistance protein 2 (MRP2/ABCC2).

61 vity of two other major efflux transporters, multidrug resistance protein 2 and breast cancer resista

62 cles ranging from 100 to 160 nm and that the multidrug resistance protein 2 and the bile salt export

63 apical membrane to subapical puncta, whereas multidrug resistance protein 2 distributions were not ch

64 The multidrug resistance protein 2 knockout (Mdr2(-/)) mice

65 harmacological inhibition with JZL184 in the multidrug resistance protein 2 knockout (Mdr2(-/-) ) mou

66 ngiocyte proliferation and liver fibrosis in multidrug resistance protein 2 knockout (Mdr2KO) mice as

67 a, hepatic fibrosis, and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse m

68 10 (apicoplast ribosomal protein S10), mdr2 (multidrug resistance protein 2) and crt (chloroquine res

69 s with primary sclerosing cholangitis and in multidrug resistance protein 2-deficient ( Mdr2-/- ) mic

70 ferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting i

71 sporters RLIP76 (Ral-binding protein) or the multidrug resistance protein-2.

72 information on the interaction of drugs with multidrug resistance protein 3 (MDR3) exists and its rol

73 ansporters, bile salt export pump (BSEP) and multidrug resistance protein 3 (MDR3).

74 The human multidrug resistance protein 3 (MDR3/ABCB4) belongs to t

75 hydroxysteroid sulfotransferase enzyme 2A1, multidrug resistance protein 3, and apical sodium-depend

76 ters of breast cancer resistance protein and multidrug resistance protein-3.

77 Human multidrug resistance protein 4 (MRP4) has recently been

78 Multidrug resistance protein 4 (Mrp4) is an efflux trans

79 Here, we report that the multidrug resistance protein 4 (MRP4), a cAMP transporte

80 drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-

81 In this study, we used multidrug resistance protein 4 (MRP4)-expressing cell li

82 The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the test

83 In this study, we evaluated the role of multidrug resistance protein 4 (MRP4, or ABCC4), a nucle

84 Multidrug resistance protein 4 (MRP4/ABCC4), transports

85 Multidrug resistance protein 4 (MRP4; ABCC4) is a member

86 ent on AC6 activation, cAMP efflux via MRP4 (multidrug resistance protein 4), extracellular cAMP meta

87 signaling cascade (phospholipase A2, COX-2, multidrug resistance protein 4, and G-protein-coupled pr

88 g that the ATP-binding cassette transporter, multidrug resistance protein 4, is able to efflux nucleo

89 We hypothesized that multidrug resistance protein 4/ATP binding cassette tran

90 We show that multidrug-resistance protein 4 (Mrp4) is abundant in mye

91 Mutations in human multidrug resistance protein 6 (MRP6, ABCC6), a member o

92 o referred to as "MRP6" or "eMOAT") encoding multidrug-resistance protein 6 (MRP6), a putative transm

93 ding overexpression of P-glycoprotein (Pgp), multidrug resistance protein 7 (MRP7), and the betaIII i

94 sette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer

95 Human multidrug resistance protein 7 (MRP7, ABCC10) is a recen

96 ucture of heterodimeric Thermus thermophilus multidrug resistance proteins A and B (TmrAB), which not

97 Pase beta (flippase), the hematopoietic cell multidrug resistance protein ABC transporter (floppase),

98 Jurkat cells express several members of the multidrug resistance protein (ABCC/MRP), and the organic

99 We have previously established that the multidrug resistance protein Abcg2 is the molecular dete

100 tivation of TGFbeta, and upregulation of the multidrug resistance protein ABCG2.

101 These factors likely include multidrug resistance proteins, aberrant signal transduct

102 on antiparallel homo- or heterodimeric small multidrug resistance proteins and examine whether the in

103 n-regulation of miRNA downstream targets and multidrug resistance proteins and extent of apoptosis we

104 nce regulator (CFTR), the P-glycoprotein (or multidrug-resistance protein) and the heterodimeric tran

105 nd chloride transport, interference with the multidrug resistance protein, and enhancement of prostac

106 c scramblases or proteins from the family of multidrug resistance proteins, and cofactors such as pho

107 teins, several plasma membrane (PM) ATPases, multidrug resistance proteins, and proteins of the stoma

108 P-Glycoprotein (Pgp) (also known as multidrug-resistance protein) contains two nucleotide bi

109 Its protein sequence places it in the multidrug resistance protein/cystic fibrosis transmembra

110 lines that overexpress P-glycoprotein or the multidrug resistance protein do not have higher levels o

111 ansfected with combinations of gamma-GCS and multidrug resistance protein exhibited enhanced resistan

112 Unlike previously characterized multidrug resistance protein family members, ABCG2 is al

113 educed folates are not identical to those of multidrug resistance protein family members.

114 EmrE is part of a multidrug resistance protein family that is highly conse

115 te (ABC) transporter homologous to mammalian multidrug resistance proteins, functions in the formatio

116 The mrp (multidrug resistance protein) gene has been associated w

117 The MRP (multidrug resistance protein) gene, a member of the ubiq

118 Mutation and/or overexpression of one of the multidrug resistance protein homologues found in this ma

119 sment of the affinity of drug candidates for multidrug resistance proteins is central to predict in v

120 P-glycoprotein (P-gp), a multidrug resistance protein, is a critical gatekeeper i

121 y substrates for p-glycoprotein (ABCB1), the multidrug resistance protein known to facilitate transde

122 empts in several clinical studies to reverse multidrug resistance protein (MDR) by using MDR modulato

123 staining pattern of the SP cells is due to a multidrug resistance protein (mdr) or mdr-like mediated

124 The efflux of antimony through multidrug resistance protein (MDR)-1 is the key factor i

125 extrusion of chemotherapeutic agents by the multidrug resistance protein MDR1 (p-glycoprotein).

126 ABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cass

127 shows in vitro inhibition of P-glycoprotein [multidrug resistance protein (MDR1); ABCB1], the in vivo

128 A Wistar Hannover rat model lacking the multidrug resistance protein Mdr1a P-glycoprotein (P-gp)

129 Mean multidrug resistance-protein-mediated drug efflux was si

130 hout overexpression of P-glycoprotein or the multidrug resistance protein MRP.

131 We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emer

132 t glutathione S-transferase (GST) P1a-1a and multidrug resistance protein (MRP) 1/2 act in synergy to

133 We have recently determined that human multidrug resistance protein (MRP) 3, which confers resi

134 eviously determined that expression of human multidrug resistance protein (MRP) 8, a recently describ

135 To address whether multidrug resistance protein (MRP) affects GO susceptibi

136 The multidrug resistance protein (MRP) family consists of ni

137 without overexpression of P-glycoprotein or multidrug resistance protein (MRP) family members sugges

138 dicate that the ABC transporter belongs to a multidrug resistance protein (MRP) family.

139 Human multidrug resistance protein (MRP) was expressed at high

140 Pgp and the multidrug resistance protein (MRP) were not elevated in

141 and primary leukemia-cell samples, including multidrug resistance protein (MRP), breast cancer resist

142 We previously found that the multidrug resistance protein (MRP), MRP1, is overexpress

143 Multidrug resistance protein (MRP)-4 localizes to the gu

144 -overexpressing MCF-7/doxorubicin cells, and multidrug resistance protein (MRP)-expressing MCF-7/etop

145 y of ABC transporter proteins defined by the multidrug resistance protein (MRP).

146 ansmembrane conductance regulator (CFTR) and multidrug resistance protein (MRP).

147 rug transporters P-glycoprotein (Pgp) and/or multidrug resistance protein (MRP).

148 rine and human cell lines overexpressing the multidrug-resistance protein (MRP) showed a marked decre

149 The multidrug resistance protein MRP1 is an ATP-binding cass

150 The multidrug resistance protein MRP1 is an ATP-driven pump

151 Previously, we showed that multidrug resistance proteins MRP1 and MRP3 attenuate cy

152 Multidrug resistance protein (MRP1) utilizes two non-equ

153 nable cell surface localization of the human multidrug resistance protein (MRP1, ABCC1) and to assess

154 The ATP binding cassette protein, multidrug resistance protein (MRP1/ABCC1), transports co

155 ned adenine nucleotide interactions with the multidrug resistance protein, MRP1, a member of a differ

156 identified as the canalicular isoform of the multidrug resistance protein (Mrp2).

157 The multidrug resistance protein MRP4, a member of the ATP-b

158 The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains

159 RECENT FINDINGS: It has been shown that the multidrug-resistance protein MRP4 may play a role in the

160 Multidrug Resistance Proteins (MRPs) are transporters th

161 ritical for firing of action potentials, and multidrug resistance proteins (MRPs) MRP4 and MRP5 contr

162 sporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique ATP-g

163 mily of ABC (ABCC) proteins, including human multidrug resistance proteins (MRPs), also possess an N-

164 subfamily includes pumps, the long and short multidrug resistance proteins (MRPs), and an ATP-gated a

165 s that is implicated in the up-regulation of multidrug resistance proteins (MRPs).

166 cs and several other endogenous metabolites, multidrug-resistance proteins (MRPs) extrude the second-

167 , can be reversed by agents that inhibit the multidrug resistance protein on the myeloma cell surface

168 f drug resistance does not appear to require multidrug resistance protein (P-glycoprotein) overexpres

169 and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than curre

170 ng cassette transporter proteins such as the multidrug resistance protein, P-glycoprotein (P-gp).

171 rge superfamily of proteins that include the multidrug resistance proteins, P-glycoprotein and MRP (m

172 P-glycoprotein, also known as multidrug resistance protein, pumps drugs out of cells u

173 rough adherens junction, tight junction, and multidrug resistance protein regulation.

174 One family of these pumps, the small multidrug resistance proteins (SMRs), consists of protei

175 ystic fibrosis conductance regulator and the multidrug resistance protein subfamily of ATP-binding ca

176 Multidrug resistance proteins that belong to the ATP-bin

177 hat overexpression of either P-glycoprotein, multidrug resistance protein type 1, or multidrug resist

178 ein, multidrug resistance protein type 1, or multidrug resistance protein type 2 has little effect on

179 ATPase activity of P-glycoprotein (multidrug-resistance protein) was found to be potently i

180 ynthetase, gamma-glutamyl transpeptidase, or multidrug resistance protein were found.

181 nt human leukemia cells (HL-60-R) expressing multidrug resistance protein when compared with wild-typ