ライフサイエンスコーパス: multifaceted

1 ice, and that this transition is complex and multifaceted.

2 cell death by La(2)O(3) NPs were found to be multifaceted.

3 roblem of resistance to therapy in cancer is multifaceted.

4 rse of the disease, and imaging findings are multifaceted.

5 only predictable, but also non-intuitive and multifaceted.

6 sponses are polymorphous, heterogeneous, and multifaceted.

7 ecting the cause-effect relationship between multifaceted activities of DNMT3A(R882mut) and leukemic

8 Overall, our data unveil the multifaceted activity of the p75(NTR) monomer and let us

9 history in the treatment of cancer, but its multifaceted activity pattern and complex side effects p

10 ess immune responses, they have potential as multifaceted adaptable smart therapeutics for treating i

11 The multifaceted adaptor protein beta-arr1 (beta-arrestin1)

12 The results clearly indicate the need for a multifaceted analytical approach, to unequivocally estab

13 une response to influenza virus infection is multifaceted and complex, involving antibody and cellula

14 pathology of inflammatory cardiomyopathy is multifaceted and complex.

15 We conclude that, although the profoundly multifaceted and context-dependent consequences of speci

16 This complexity is readily reflected by the multifaceted and contextual involvement of complement-dr

17 involved in, and the subsequent effects are multifaceted and depend on several host- and pathogen-de

18 evolution of plant-microbe interactions are multifaceted and depend on the particular nature of each

19 Our results provide a cohesive view of a multifaceted and evolutionarily constrained system that

20 CRPC is a complex, multifaceted and heterogeneous malady with limited stand

21 applications in radiation oncology given the multifaceted and highly technical nature of this field o

22 Advances in clinical care have been multifaceted and include earlier diagnosis through the i

23 Mitochondria are multifaceted and indispensable organelles required for c

24 lar mechanisms that dictate CNS function are multifaceted and it is unclear how irradiation induces p

25 Disease management is multifaceted and multidisciplinary, and is focused on th

26 Alzheimer's disease (AD) is a multifaceted and progressive neurodegenerative disease c

27 sults imply that the process of widowhood is multifaceted and that various types of health changes sh

28 These findings thus uncover ROCK2 as a multifaceted and therapeutically targetable regulator of

29 s likely to be achieved through longer-term, multifaceted, and collaborative approaches, with support

30 We propose that a multifaceted anti-inflammatory strategy based on pharmac

31 inflammatory neutrophils holds promise as a multifaceted antiinflammatory strategy.

32 tion of peptidic dendrimers along with their multifaceted applications in various fields.

33 This multifaceted approach allowed access to up to gram quant

34 l rhythm, duration of the cardiac arrest), a multifaceted approach considering both potential for neu

35 Using a multifaceted approach in mice of both sexes, we found th

36 Using a multifaceted approach in mice, we have identified vasoac

37 This multifaceted approach is adaptable to Academic Surgery u

38 Our multifaceted approach is the first to link microglia to

39 Overall, our multifaceted approach provides a comprehensive and consi

40 This will require a multidisciplinary, multifaceted approach that includes recognizing alcohol

41 iovascular health of LGBTQ adults requires a multifaceted approach that includes stakeholders from mu

42 A multifaceted approach that incorporates genetic and phen

43 sible health disparities research requires a multifaceted approach to address genetic, biological, so

44 s areas that demonstrate a cross-cutting and multifaceted approach to addressing cardiovascular scien

45 an American (black) community, and suggest a multifaceted approach to addressing these healthcare dis

46 In this study, we used a multifaceted approach to identify ligands of orphan SLC2

47 Here, we take a multifaceted approach to investigate whether tagging lea

48 expression could be applicable as part of a multifaceted approach to optimize the production of HSPC

49 Here we use a multifaceted approach to understand both the spatial dis

50 Improving outcomes will depend on a multifaceted approach, including correction of modifiabl

51 A multifaceted approach, including in vitro whole-cell pat

52 For this exploration, we took a multifaceted approach, starting with a high-throughput i

53 Here using a multifaceted approach, we show that the CPC binds nucleo

54 inical and lifestyle factors, motivating the multifaceted approaches currently endorsed for primary a

55 The strategies for sugar reduction involve multifaceted approaches including the use of alternative

56 lation forecasts dictate a rapid adoption of multifaceted approaches to fulfill increasing food requi

57 ns of interest, recent studies have employed multifaceted approaches using health behaviors and/or st

58 of next-generation wearable electronics and multifaceted artificial intelligence systems.

59 ling inhibition by NO2-OA in TNBC cells were multifaceted, as NO2-OA (a) inhibited the inhibitor of N

60 nt knowledge in an attempt to untangle these multifaceted associations from an epidemiological perspe

61 mical properties to cross one or some of the multifaceted barriers.

62 strategy to mimic bariatric surgery with its multifaceted beneficial effects on food intake, body wei

63 This paper synthesizes ideas stressing the multifaceted biological relevance of phytoplankton chytr

64 Injury or disease to the CNS results in multifaceted cellular and molecular responses.

65 Finally, we discuss the multifaceted cellular functions of biomolecular condensa

66 Addressing this translational gap is a multifaceted challenge, for which a key aspect is the se

67 ipid oxidation and ketogenesis, and produced multifaceted changes in flux through the individual step

68 king by charge disproportionation results in multifaceted changes in the electronic, magnetic and opt

69 The multifaceted character of 5f electrons in actinide mater

70 The synergy of multifaceted characterization and device physics is used

71 Multifaceted characterizations of human cancer cell line

72 construction of in vitro networks capable of multifaceted chemical and material regulation.

73 om the skin, which provides insight into the multifaceted chemical influences on our health.

74 Owing to the multifaceted clinical presentation, diagnosis remains a

75 properties in fat-continuous dispersions is multifaceted compared to bulk oils, which limits the abi

76 a non-MYCN-amplified cohort and indicate the multifaceted complexity of PRMT1 as a biological regulat

77 these unmet needs, the "immunome" is a key, multifaceted component in the initiation and overall res

78 u-UiO-66 were experimentally determined, and multifaceted computational methods were used to corrobor

79 t are particularly damaging for the study of multifaceted constructs like self-regulation.

80 These results suggest a multifaceted contribution of GABA, through regulation of

81 Atherosclerosis is driven by multifaceted contributions of the immune system within t

82 ts indicate that RBC-targeted scFv/TM exerts multifaceted cytoprotective effects and may find utility

83 nplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dys

84 y distinct, but mechanisms that control this multifaceted development are poorly understood.

85 ake them prime candidates for integration in multifaceted devices.

86 Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immu

87 ncephalopathy of prematurity encompasses the multifaceted diffuse brain injury resulting from preterm

88 t on the interplay of components involved in multifaceted disease responses, like atherosclerosis.

89 nal single-cell tools to uncover its role in multifaceted diseases such as rheumatic diseases, as wel

90 Drug abuse is a multifaceted disorder that involves maladaptive decision

91 pid climate warming in the Arctic results in multifaceted disruption of biodiversity, faunal structur

92 Instead, ParA-AMPPNP dimerization creates a multifaceted DNA-binding surface, allowing it to prefere

93 based interventions while accounting for the multifaceted, dynamic sociotechnical context affecting i

94 However, the causal role for such a multifaceted effect of DNMT3A(R882mut) in leukemogenesis

95 -based approaches in addressing the complex, multifaceted effects of changing climate conditions on h

96 Notably, these multifaceted effects of estrogen are mostly mediated by

97 genesis and provide further insight into the multifaceted effects of HU treatment.

98 Thus, antigen valency has multifaceted effects on B cell responses and can dictate

99 s on a limited number of traits and miss the multifaceted effects that warming may have on organisms,

100 Multifaceted efforts focusing on all three types of over

101 hat the self-assembly of small molecules, as multifaceted entities and processes to interact with mul

102 These multifaceted enzymes limit the accumulation of short-liv

103 ted opportunities for researchers to conduct multifaceted examination of the genome on a large scale.

104 her combinatorial mechanisms can explain its multifaceted existence.

105 This integrated computational and multifaceted experimental approach expands the peptide-G

106 Herein, we reported a multifaceted experimental approach that reveals the beha

107 TooManyCells enables multiresolution and multifaceted exploration of single-cell clades.

108 ineate ILC precursor states by revealing the multifaceted expression of key ILC-associated transcript

109 ing embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue h

110 elective ion permeability using an automated multifaceted fluorescence-based screening.

111 Through multifaceted functional data analysis, we found that AR-

112 of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings c

113 , these findings indicate that REM sleep has multifaceted functions in brain development, learning an

114 R)-targeted HSP40 co-chaperone that performs multifaceted functions involved in coordinating ER and e

115 This article summarizes how these multifaceted functions of exosomes may promote developme

116 Here we consider the multifaceted functions of factors recruited to perpetuat

117 ces and new insights in understanding of the multifaceted functions of ORMDL3 in patients with allerg

118 The multifaceted functions of the brain are borne through se

119 lex starting materials to produce a range of multifaceted gamma-aryl tertiary alkylamines and can be

120 In this Primer, I summarise how this multifaceted gene functions in various mammalian tissues

121 eening in predicting biological responses to multifaceted global change.

122 e, through S-adenosylmethionine, activates a multifaceted growth program in which ribosome biogenesis

123 These integrated analyses also uncovered multifaceted immune cell activation within brain maligna

124 ng of the intracellular environment, and its multifaceted immune evasion strategies.

125 te co-delivery leading to the induction of a multifaceted immune response at low antigen and CpGODN d

126 uated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity

127 L12 axis to inhibit tumor growth and prevent multifaceted immunosuppression alone or in combination w

128 indings demonstrate that brain cancers cause multifaceted immunosuppression and pinpoint circulating

129 rk), suggesting that feedback signals have a multifaceted impact on future decisions.

130 rious cancers, not much is known about their multifaceted impact on the exhausted CD8(+) T cell recep

131 In this study, we observed that a multifaceted implementation package was clinically and c

132 aim was to evaluate the impact of a tailored multifaceted implementation program of ICU delirium guid

133 ality improvement collaborative leveraging a multifaceted implementation strategy.

134 oposed molecular mechanisms involved and the multifaceted implications of vessel co-option for patien

135 ta provide evidence of how poxviruses can be multifaceted in their mimicry of cellular proteins throu

136 and molecular factors converge to mould the multifaceted, inextricable connection between MGEs and a

137 e care unit in Zambia where we implemented a multifaceted infection prevention and control (IPC) bund

138 ed by Bp and Bm.Melioidosis and glanders are multifaceted infections caused by gram-negative bacteria

139 ating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one

140 densates in cellular-like conditions through multifaceted interactions involving all structural regio

141 l therapeutic strategies for targeting these multifaceted interactions.

142 Phe accumulation had multifaceted intercompartmental effects on aromatic amin

143 We evaluated whether a multifaceted intervention (AKI e-alerts, an AKI care bun

144 gene expression, highlighting the need for a multifaceted intervention approach to combat P. vivax in

145 Conclusion: Our multifaceted intervention significantly increased HCV sc

146 We performed a multifaceted intervention that included provider and pat

147 We organized a multifaceted intervention to improve adherence with evid

148 We examined the effectiveness of a multifaceted intervention to improve HCV screening in a

149 A multifaceted intervention was associated with improved c

150 uality improvement initiative was based on a multifaceted intervention.

151 Five additional primary studies of multifaceted interventions met the inclusion criteria.

152 Finally, we show that RET drives a multifaceted intracellular signaling pathway, including

153 In a multifaceted investigation combining local soft X-ray an

154 cific B cell response is exactly that: it is multifaceted, involves both innate-like and conventional

155 e and operational costs of CO2 capture, is a multifaceted issue involving thermal, hydrothermal, and

156 fining feature of meiosis, is established by multifaceted kinase control by a master regulator.

157 d diverse watershed nitrogen sources require multifaceted management approaches.

158 of treatment and should be complemented by a multifaceted management strategy that includes counselin

159 Multifaceted measures, including regulatory intervention

160 ttractive polymechanophore system to explore multifaceted mechanical response in solution and solid s

161 Our results provide novel insights into the multifaceted mechanism of SYS signaling transport and it

162 The evidence supports a multifaceted mechanism wherein a small amount of an init

163 ings provide novel insights into the complex multifaceted mechanisms of action behind secretome-media

164 ified PI3K/Akt regulation of glycolysis as a multifaceted modulator of single-cell metabolic dynamics

165 ited as building blocks for the synthesis of multifaceted molecular structures, especially for pharma

166 A multifaceted national effort employed novel strategies t

167 well understood, as it is complicated by the multifaceted nature of bacterial virulence, which has so

168 Due to the complex, multifaceted nature of DA signaling, analytical sensing

169 This multifaceted nature of mast cells is made possible by in

170 do not sufficiently reflect the complex and multifaceted nature of perioperative care in patients wi

171 ndividual intervention components, given the multifaceted nature of the implementation package, and t

172 Tau is a multifaceted neuronal protein that stabilizes microtubul

173 brain development and sex to impart risk for multifaceted neuropsychiatric disorders is also unlikely

174 Overall, our study demonstrates the multifaceted oncogenic function of the protein lysine me

175 Modulation at the level of C3, a multifaceted orchestrator of the complement cascade, ope

176 A multifaceted outpatient stewardship intervention achieve

177 onatal death following the introduction of a multifaceted oxygen system compared to introducing pulse

178 introduction, and stepped introduction of a multifaceted oxygen system.

179 rmation out of individual pancreas providing multifaceted parameters to study the intrinsic heterogen

180 s a presynaptic mechanism to consider in the multifaceted pathogenic pathways of progressive neurodeg

181 Immunity is a multifaceted phenomenon.

182 ce from 18 CC strains were evaluated using a multifaceted phenotyping pipeline to define their unique

183 Our observations point to GRFs as new multifaceted players in Ribi gene regulation both during

184 in childhood and adolescence are complex and multifaceted, presenting researchers and clinicians with

185 Waste in research is a multifaceted problem without a simple solution.

186 efficient surface protection to address the multifaceted problems, which is a significant step forwa

187 Post-MI cardiac remodeling is a multifaceted process that includes activation of fibrobl

188 Decision making is a multifaceted process, consisting of several distinct pha

189 capacity for recovery, which highlights the multifaceted processes that underlie the global decline

190 TGF-beta1 orchestrates the multifaceted program of renal fibrogenesis involving pro

191 Our results showed that multifaceted protein engineering, far beyond a few amino

192 Our results highlight that Dnmt3b is a multifaceted protein that serves as an enzyme, an access

193 We propose that these multifaceted protein-protein interaction properties are

194 During the study period, a multifaceted quality improvement initiative was institut

195 Rice grain quality is a multifaceted quantitative trait that impacts crop value

196 te Plasmodium Their functions are strikingly multifaceted, ranging from hemoglobin degradation to sec

197 The COVID-19 pandemic has necessitated a multifaceted rapid response by the scientific community,

198 rall, these results provide insight into the multifaceted regulation of RRM2 protein levels and ident

199 Transduction of these signals has a multifaceted regulation that includes important cell-mat

200 Our observations suggest that glycine is a multifaceted regulator of d-serine metabolism and implic

201 ctivate critical signaling cascades and have multifaceted regulatory functions in the immune system.

202 ferences in pUL97 interactions and suggest a multifaceted regulatory impact of cyclins on HCMV replic

203 To further investigate this multifaceted relationship, a human pilot study examined

204 ry tissue, which has the potential to induce multifaceted reparative effects in the environment withi

205 We demonstrate that CXCR4 exhibits a multifaceted response that involves dynamic receptor dim

206 We show that CXCR4 presents a multifaceted response to CXCL12, with receptor activatio

207 auditory processes, the FFR is an uncommonly multifaceted response yielding a wealth of information,

208 The Ewing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established

209 Thus, GPR37 plays a multifaceted role after stroke, suggesting a novel targe

210 her, these findings indicate that E2 plays a multifaceted role during development, and that, contrary

211 Our results suggest a multifaceted role for AKAPs in the cell.

212 Thus, our data reveal a novel multifaceted role for AnxA1 to act both as a therapeutic

213 nd FIs in antiviral therapies and point to a multifaceted role for chemokine receptor binding in prom

214 Taken together, these data revealed a multifaceted role for PAR-1 in leukemogenesis, and highl

215 Our data highlight a multifaceted role for TMEM30A in B-cell lymphomagenesis,

216 tumor suppressor protein TP53 (p53) plays a multifaceted role in all cells of the human body.

217 Platelets play a multifaceted role in cancer progression and metastasis.

218 demonstrates that CYP2J2 plays a central and multifaceted role in cardiomyocyte homeostasis and provi

219 ndings suggest that CD73 and A(2B) AR play a multifaceted role in GB pathogenesis and progression and

220 MeCP2 plays a multifaceted role in gene expression regulation and chro

221 aration events likely play a significant and multifaceted role in germ cells and development.

222 findings demonstrate that SHP2 thus plays a multifaceted role in inducing immune suppression in the

223 y conserved eukaryotic nuclease that plays a multifaceted role in maintaining genome stability.

224 Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence, and

225 y has identified a new AR coregulator with a multifaceted role in prostate cancer, functioning as an

226 findings highlight the hippocampus playing a multifaceted role in socially adaptive learning.

227 findings highlight the hippocampus playing a multifaceted role in socially adaptive learning.SIGNIFIC

228 iperin) is a radical SAM enzyme that plays a multifaceted role in the cellular antiviral response.

229 Ligation plays a multifaceted role in the chemistry of SmI(2).

230 Viperin plays an important and multifaceted role in the innate immune response to viral

231 Among their multifaceted role in the modulation of biological respon

232 We find that although LIN28 has a multifaceted role in the number and types of cells produ

233 endothelial cells (ECs), a cell type with a multifaceted role in vasculature.

234 udies have expanded our understanding of the multifaceted role of adipose tissue in metabolic health

235 of this disorder, here we shed light on the multifaceted role of diverse types of lipid in mediating

236 Our report highlights the underappreciated multifaceted role of IRF-1 in MHV68 infection and pathog

237 Our data highlight the multifaceted role of MADD as a signalling molecule in di

238 In this review, we highlight the multifaceted role of mechanics in pattern formation, fro

239 Taken together, our findings highlight the multifaceted role of miR-155 in T cells, in which it pro

240 article highlights recent advances about the multifaceted role of the 'matrixome' in the development,

241 ries of rTPJ function should account for the multifaceted role of the rTPJ in the representation of s

242 y step in the FA pathway and help define the multifaceted role of the USP1-UAF1-RAD51AP1 complex in D

243 Recent work has shed light on the multifaceted role that the community of organisms in and

244 PP plays a multifaceted role, slowing the reaction by complexing bo

245 T cells play important multifaceted roles during dengue infection, and understa

246 neuron efferent targets, highlighting their multifaceted roles in addiction.SIGNIFICANCE STATEMENT G

247 physiologically important functions and play multifaceted roles in bacterial infection.

248 n this review, we provide an overview of the multifaceted roles of astrocytes in the context of CNS i

249 The diverse structures and multifaceted roles of carotenoids make these colorful pi

250 for the regulatory mechanism underlying the multifaceted roles of florigen.

251 mechanisms were identified that regulate the multifaceted roles of RARs in the salamander limb includ

252 These multifaceted roles of serotonin in locomotion are differ

253 es have transformed our understanding of the multifaceted roles of this adaptable organ.

254 These results reveal multifaceted roles of YAP in PDAC pathogenesis and under

255 emical attributes of these complexes and the multifaceted roles that they fulfill in genome maintenan

256 o determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory.

257 rogenitor cells comprise subpopulations with multifaceted secretion, and their derived hypothalamic i

258 This FO-TENG represents a smart multifaceted sensing platform that has a unique capacity

259 a deeper understanding of the intricate and multifaceted set of regulatory mechanisms in the control

260 We developed a 12-month, multifaceted short messaging service intervention (WHISP

261 rd and motor behaviors are delineated by the multifaceted signaling protein neurofibromin 1 (NF1).

262 New concepts have emerged exploring the multifaceted significance of myocardial injury, minimal

263 indicated that the two diseases overlap in a multifaceted spectrum of conditions.

264 ization reactions carried out exclusively by multifaceted sRNAs that are both targets of and triggers

265 A comprehensive multifaceted SSI reduction bundle can be successfully im

266 A multifaceted SSI reduction bundle was developed and impl

267 ycling cascade employing cycloalkylamines as multifaceted starting materials for the synthesis of nyl

268 -to-balloon time to a comprehensive focus on multifaceted STEMI care offers an opportunity to further

269 ic GABA(A) receptor, it maintains a rich and multifaceted steroid pharmacology.

270 ciple for functional biomaterials exhibiting multifaceted stimuli on differentiation programs.

271 unexplored mechanism in which cells exploit multifaceted strategies in a highly cooperative manner t

272 cies for improving the food environment need multifaceted strategies to invoke clinically meaningful

273 By combining these methods with multifaceted strategies to monitor protein folding, degr

274 be integrated with engineered hotspots as a multifaceted strategy to further boost SERS sensitivitie

275 Addressing realistic, multifaceted stressor exposures and multiple biological

276 We conclude that skin is a multifaceted structure that provides a fertile ground fo

277 In this work, first a multifaceted study of the influence of various factors o

278 In this multifaceted study we have resolved the date of the erup

279 This multifaceted sustainable catalysis is a unique tool, esp

280 By employing a multifaceted synthetic strategy to prepare peptide-targe

281 The successful fit of this complex, multifaceted system demonstrates generality of the metho

282 HPS patients displayed a multifaceted, systemic inflammatory response, with IL-6

283 ered Ca(2+) oscillations is more complex and multifaceted than previously believed.

284 se results demonstrate that VEGFCc156s had a multifaceted therapeutic effect to prevent angiotensin I

285 OVs offer a multifaceted therapeutic platform because they preferent

286 ormation is used to guide the application of multifaceted therapy.

287 Our results highlight the multifaceted threats that climate change poses on migrat

288 Multifaceted, three-phase (baseline, delirium screening,

289 tions aimed at improving adherence should be multifaceted to target these barriers.

290 still a high demand for a comprehensive and multifaceted tool suite to analyze, annotate, QC, and vi

291 ral relevant metabolic pathways suggesting a multifaceted toxicity of BMAA including: (1) localized p

292 vestigation of the role of this functionally multifaceted transcription factor in enhancer and riboso

293 er expands our understanding of this complex multifaceted transcription factor.

294 response profiles of gene circuits, lending multifaceted tuning capacities including reducing basal

295 Such a property is expected to find multifaceted use exemplified by transportation and infra

296 n-SMAD components of TGF-beta signaling in a multifaceted way.

297 fluencing neuronal and synaptic functions in multifaceted ways.

298 As reward is multifaceted, we sought convergent evidence from subject

299 field of abdominal organ transplantation is multifaceted, with the clinician balancing recipient com

300 These multifaceted wounds can be highly complex and must be qu