ライフサイエンスコーパス: multifactorial

1 tiology of EDS can be challenging and may be multifactorial.

2 t merely depend on electrostatics, but it is multifactorial.

3 besity and hypertension, its pathogenesis is multifactorial.

4 risk of haemorrhage and dire consequences is multifactorial.

5 The causes of obesity are complex and multifactorial.

6 ed hOCT1-mediated sorafenib uptake by CCA is multifactorial.

7 rrhosis can be challenging as they are often multifactorial.

8 ns for this are unknown and are likely to be multifactorial.

9 effect of Mt transfer are unclear and likely multifactorial.

10 underlying racial disparities in cancer are multifactorial.

11 ving emergence of resistance are complex and multifactorial.

12 gonism are poorly understood but most likely multifactorial.

13 Anabolic resistance is thus multifactorial.

14 bodies (DLB) and Parkinson disease (PD) are multifactorial.

15 is are not fully elucidated but appear to be multifactorial.

16 The reasons for dyspnea are often multifactorial.

17 ease are not fully understood and are likely multifactorial.

18 nderlying mechanisms of HAND are complex and multifactorial.

19 sk in BL women remains unclear and is likely multifactorial.

20 ed (16, 30.2%), system-related (1, 1.9%), or multifactorial (17, 32.1%) reasons.

21 and late hospice use in this population are multifactorial, a key barrier is limited access to blood

22 Mutations underlying HIF deregulation drive multifactorial aberrations in angiogenic signals and met

23 for a hybrid scenario involving the gradual, multifactorial adaptation to the inhibitors through acqu

24 Ischaemic heart disease has a multifactorial aetiology and can be prevented from devel

25 jority of individuals, nephrolithiasis has a multifactorial aetiology involving genetic and environme

26 sease is a neurodegenerative disorder with a multifactorial aetiology.

27 Although the development of OC is likely multifactorial, agr group III organisms, prolonged fever

28 Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic st

29 ed with the risk of work disability, but few multifactorial algorithms exist to identify individuals

30 ctions, and cell types within skin to enable multifactorial analysis of skin pharmacokinetics.

31 We conducted a multifactorial analysis that demonstrates how stimulus t

32 We undertook a multifactorial analysis using the Cox proportional hazar

33 hepatic encephalopathy (HE) in cirrhosis is multifactorial and ammonia is thought to play a key role

34 er orthotopic heart transplantation (OHT) is multifactorial and can be an indicator of graft rejectio

35 Risk of disease is multifactorial and can be shaped by socio-economic, demo

36 specific ageing as a key contributor to this multifactorial and complex disease.

37 es from barriers to adherence that are often multifactorial and complex.

38 The mechanisms guiding HTS formation are multifactorial and complex.

39 The reasons for differences are multifactorial and could not be determined by this study

40 related cataracts, and the visual outcome is multifactorial and dependent on postoperative visual reh

41 Although reasons for underuse are multifactorial and differ from country to country, the n

42 An ideal multifactorial and early intervention to prevent cancer

43 thogenesis of craniofacial birth defects are multifactorial and include both genetic and environmenta

44 for strategic rescheduling of operations is multifactorial and includes our societal responsibility

45 The pathophysiology of malarial anemia is multifactorial and incompletely understood.

46 ome insects to tolerate low temperatures are multifactorial and involve several physiological systems

47 The CMT-causing mechanism is likely to be multifactorial and involves multiple cellular compartmen

48 The cause of ND seems to be multifactorial and less well understood, with some dispa

49 cursors argues that the development of MA is multifactorial and may follow, in part, a non-neovascula

50 Reasons for delays are multifactorial and may, in part, be related to poorer lo

51 asons for sertraline inactivity appear to be multifactorial and might be associated with insufficient

52 ases, which includes chromosomal, monogenic, multifactorial and mitochondrial diseases.

53 e rates of cirrhosis reported in Halland are multifactorial and most likely related to higher inciden

54 Multifactorial and multigenerational implications of tot

55 isms of fat alterations in PLWH are complex, multifactorial and not fully understood, although they a

56 because most believe that quality of care is multifactorial and not represented by an individual's mo

57 rlying mechanism of insulin sensitization is multifactorial and not through the canonical insulin/Akt

58 ane oxygenation-associated coagulopathy is a multifactorial and quickly developing syndrome.

59 immunity, both directly and indirectly, are multifactorial and reflect the complexity of the gut-liv

60 erlying abnormal LFTs in COVID-19 are likely multifactorial and related to a hyper-inflammatory statu

61 Reduced bone density in this population is multifactorial and related to growth, degree of cholesta

62 The causes of steroid-resistant asthma are multifactorial and result from complex interactions of g

63 nt disparities in cardiovascular disease are multifactorial and span from the individual level to the

64 protection from neuroinvasion and disease is multifactorial and that several immune outcomes can cont

65 The causative mechanisms are multifactorial and there are no effective treatments for

66 ogy of benign prostatic hyperplasia (BPH) is multifactorial, and chronic inflammation plays a pivotal

67 Lung cancer etiology is multifactorial, and growing evidence has indicated that

68 The etiology of human NASH is multifactorial, and identifying reliable molecular playe

69 athogenesis of S. agalactiae UTI is complex, multifactorial, and influenced by virulence effects of C

70 the age of 10 years, the disease is complex, multifactorial, and lifelong, and affects nutrition and

71 Extubation failure is multifactorial, and most tools to assess extubation read

72 of femoropopliteal artery (FPA) stenting is multifactorial, and severe FPA deformations occurring wi

73 Data were evaluated using multifactorial-ANOVA, response surface analysis and Prin

74 The multifactorial approach can reveal subtypes that are dif

75 Here, we propose a multifactorial approach designed to optimize HCP detecti

76 commitment, it might be useful to consider a multifactorial approach that highlights building trust i

77 ors contribute to ischaemic heart disease, a multifactorial approach to prevention is recommended, st

78 Another, a multifactorial approach, tackles the heterogeneity probl

79 This multifactorial arrhythmia is intertwined with common con

80 mprovement strategies (eg, case management), multifactorial assessment and treatment (eg, comprehensi

81 ent-level quality improvement strategies and multifactorial assessment and treatment relative to usua

82 tion for utilization, it should be part of a multifactorial assessment with established prognostic do

83 outcomes reported from clinical practice are multifactorial, availability of reliable, reproducible,

84 Here, we described a novel approach (termed Multifactorial Behavioral Assessment (MfBA)) to integrat

85 effect of each liposome design parameter on multifactorial biological endpoints including both in vi

86 natures of TGF-beta and Notch pathways, with multifactorial biological outcomes.

87 Cyclosporine A-induced nephrotoxicity is multifactorial but oxidative stress has a critical role

88 This disease is multifactorial, but a primary factor is cariogenic micro

89 CE Host susceptibility to viral infection is multifactorial, but early control of viruses not previou

90 IBD is known to be multifactorial, but inflammatory signaling within the in

91 The pathophysiology of CRPC is clearly multifactorial, but most often, androgen receptor (AR) u

92 We discuss the multifactorial causes, such as deprivations during long

93 One important reason might be that AMI is multifactorial, causing cardiomyocyte death via multiple

94 ile and quantitative approach to investigate multifactorial cell-stress emergent from diverse bioinst

95 g of glucocorticoid action and emphasize the multifactorial, cell-specific effects of these drugs, wi

96 e our understanding of the heterogeneity and multifactorial character of psychiatric disorders.

97 Multifactorial ChIP-seq data integration from the endome

98 Asthma is a widespread, multifactorial chronic airway disease.

99 isease (CD) and ulcerative colitis (UC), are multifactorial chronic conditions of the gastrointestina

100 Periodontitis is a complex, multifactorial chronic disease involving continuous inte

101 Age-related macular degeneration (AMD) is a multifactorial chronic disease that requires long term t

102 The role of retinol in the prevention of multifactorial chronic diseases remains uncertain, and t

103 Aqueous tear-deficient dry eye is a multifactorial chronic disorder in which the lacrimal gl

104 a to understanding coronary heart disease as multifactorial, chronic disease.

105 netic causes of hypertriglyceridemia, termed multifactorial chylomicronemia syndrome (MFCS); a defici

106 lumn temperature, mobile phase gradient or a multifactorial combination in reversed phase and ion exc

107 ere no genetic testing options available for multifactorial complex diseases like heart disease, diab

108 The development of inhibitors is a multifactorial complication involving environmental and

109 upstream kinases of ERK1/2 signaling, alters multifactorial components of the innate and adaptive imm

110 ctions between PrLDs support the assembly of multifactorial condensates at a synthetic locus within l

111 t Lip and/or Palate (NSCLP) is regarded as a multifactorial condition in which clefting is an isolate

112 Obesity is a multifactorial condition influenced by genetics, lifesty

113 disease unclassified (IBDU) is a complex and multifactorial condition with increasing incidence.

114 ted considerably to the inclusion of complex multifactorial conditions with an autoinflammatory basis

115 This suggests that anxiety is a multifactorial construct phenotypically and aetiological

116 We found that spatial anxiety is a multifactorial construct, including two components: navi

117 ions that relate to just one aspect of these multifactorial constructs.

118 populations, cardiovascular diseases feature multifactorial contributions from both genetic and envir

119 Multifactorial data analysis of DeltaCt values identifie

120 This multifactorial definition can determine PTSD risk before

121 evalent (1 in 2000), genetically complex and multifactorial, degenerative disease of the cornea whose

122 Using a multifactorial design, the effect of soy lecithin (L) an

123 opose that resilience can be quantified as a multifactorial determinant of physiological parameters,

124 Multifactorial determinants of breastfeeding need suppor

125 modern approach to obesity acknowledges the multifactorial determinants of weight gain and the healt

126 's g factor for intelligence to denote these multifactorial determinants.

127 gh the pathogenesis of the cardiomyopathy is multifactorial, diabetic dyslipidaemia and intramyocardi

128 all randomized controlled trials evaluating multifactorial dietary interventions in adults with chro

129 etics and candidate modifier genes in PXE, a multifactorial disease at the genome-environment interfa

130 Atherosclerosis is a complex, multifactorial disease characterized by the buildup of p

131 Metabolic syndrome (MetS) is a multifactorial disease cluster that consists of dyslipid

132 lated macular degeneration (AMD) is a common multifactorial disease in the elderly with a prominent g

133 Alzheimer's disease (AD) is a complex, multifactorial disease in which different neuropathologi

134 Dry Eye Disease (DED) is a multifactorial disease of the interpalpebral ocular surf

135 rant epithelial pro-fibrotic response in the multifactorial disease pathogenesis.

136 mellitus (T2DM) is an increasingly prevalent multifactorial disease that has both genetic and environ

137 Age-related macular degeneration (AMD), a multifactorial disease with variable phenotypic presenta

138 Male osteoporosis is a multifactorial disease, although it is often in part rel

139 zheimer's disease: inseparable partners in a multifactorial disease.

140 wn about the mechanisms driving this complex multifactorial disease.

141 ebral disc (IVD) disease (IDD) is a complex, multifactorial disease.

142 Increased molecular understanding of multifactorial diseases paves the way for novel therapeu

143 in drug discovery owing to the complexity of multifactorial diseases such as cancer, inflammation, or

144 ecific proteins, including those involved in multifactorial diseases such as cancer.

145 the progression or the development of these multifactorial diseases through diet is an emerging and

146 Multifactorial diseases, including autoimmune juvenile i

147 Alzheimer's disease (AD), like other multifactorial diseases, is the result of a systemic bre

148 t be more effective in the treatment of such multifactorial diseases.

149 d be used to address the polygenic nature of multifactorial diseases.

150 ted macular degeneration (AMD) is a chronic, multifactorial disorder and a leading cause of blindness

151 Hirschsprung disease (HSCR), a multifactorial disorder of enteric nervous system (ENS)

152 n deficit hyperactivity disorder (ADHD) is a multifactorial disorder with diverse associated risk fac

153 Although AD is clearly a complex multifactorial disorder, an infectious disease etiology

154 er with CB2R, other targets involved in such multifactorial disorders.

155 knockdowns but will also be useful to study multifactorial disorders.

156 arkable progress in our understanding of the multifactorial drivers of hippocampal aging and cognitiv

157 Screening of children for multifactorial dyslipidemia has not been evaluated in ra

158 s (HAT) after liver transplantation (LT) are multifactorial, early HAT (E-HAT) remains pertinent comp

159 The results indicated a multifactorial effect of the HLA-DR4 transgene on develo

160 Primary liver cancer develops from multifactorial etiologies, resulting in extensive genomi

161 es to which periodontitis is associated have multifactorial etiologies.

162 These findings support a multifactorial etiology, involving congenitally predispo

163 Cervical tumorigenesis is characterized by a multifactorial etiology, with oxidative stress (OS) like

164 ong the most common human birth defects with multifactorial etiology.

165 Therefore, we propose that more multifactorial experiments should be considered in study

166 ies for estimating associations with complex multifactorial exposures like obesity.

167 [CI], 0.91 to 1.59), and the rate ratio with multifactorial fall prevention as compared with advice b

168 nd 3301 to falls-risk screening and targeted multifactorial fall prevention in addition to advice by

169 ening for falls, and targeted interventions (multifactorial fall prevention or exercise for people at

170 ts (one episode of angina, one fall during a multifactorial fall-prevention assessment, and one hip f

171 y 2854 of the 3301 participants (87%) in the multifactorial fall-prevention group.

172 sent to persons assigned to the exercise and multifactorial fall-prevention groups.

173 Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repe

174 Thrombocytopenia is a common, multifactorial, finding in ICU.

175 isease and those contributing to the common, multifactorial form of the disease.

176 These data identify multifactorial functions and diverse mechanisms whereby

177 The study observed multifactorial gender-specific ibuprofen-mediated effect

178 s) of soil bacteria and fungi in a long-term multifactorial global change experiment with warming (+3

179 Lethal total body irradiation (TBI) triggers multifactorial health issues in a potentially short time

180 Cardiogenic shock (CS) is a multifactorial, hemodynamically complex syndrome associa

181 l, and circumstantial evidence, we present a multifactorial hypothesis that has potential direct impl

182 dden infant death syndrome is believed to be multifactorial, ie, occurs in infants with underlying bi

183 g neurodevelopment alterations in terms of a multifactorial immune milieu, or immunome, to determine

184 ery cohort of melanoma patients suggest that multifactorial immune signatures have the potential to a

185 hough PN-associated liver disease (PNALD) is multifactorial in etiology, components of soybean oil li

186 he efficacy of a therapeutic intervention is multifactorial in nature and in many cases the source of

187 in clinical trials of ART initiation, and is multifactorial in nature, with demographic factors, HIV-

188 in clinical trials of ART initiation and is multifactorial in nature, with demographic factors, HIV-

189 o hypoperfusion of the spinal cord, which is multifactorial in origin, including small aortic calibre

190 Q to detect HIV-1 infection was frequent and multifactorial in origin.

191 ave not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of A

192 The factors driving PPIN rewiring are multifactorial including changes in protein expression a

193 The mechanism of ISR is multifactorial, including biological, mechanical, patien

194 The etiology of orofacial clefting is multifactorial, including genetic or environmental facto

195 for the reduction in fibrogenesis in vivo is multifactorial, including not only a reduction in the nu

196 disparity are not as obvious and are likely multifactorial, including socioeconomic and health care

197 The reasons for this are multifactorial, including the absence of a validated "ra

198 Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patient

199 Acne is a multifactorial inflammatory skin disease with high preva

200 plaque psoriasis and psoriatic arthritis are multifactorial inter-related diseases with strong geneti

201 zed trial to evaluate the effectiveness of a multifactorial intervention that included risk assessmen

202 ng for fall risk, and a targeted exercise or multifactorial intervention to prevent falls did not res

203 A multifactorial intervention, administered by nurses, did

204 propose a framework for screening and early multifactorial interventions as the best prospect for pr

205 Treatment of CS is often multifactorial, involving a combination of antigranuloma

206 The pathogenesis is multifactorial, involving genetic predisposition, epithe

207 ssion and blockade of KC differentiation are multifactorial, involving pathways that converge on tran

208 Amyotrophic lateral sclerosis (ALS) is a multifactorial lethal motor neuron disease with no known

209 Although the etiology of stress fractures is multifactorial, lower bone strength increases risk.

210 Acute respiratory distress syndrome is a multifactorial lung injury that continues to be associat

211 Parkinson's disease (PD) is a multifactorial malady and the second most common neurode

212 and wildcards) and results can be sorted in multifactorial manner using assistive filters.

213 but its clinical utility is often limited by multifactorial mechanism of resistance.

214 earch performed during the last decades, the multifactorial mechanism responsible for white wine prot

215 er, it also revealed a much more complex and multifactorial mechanism shaping craniofacial morphology

216 The multifactorial mechanisms driving negative health outcom

217 The assumed multifactorial mechanisms include ischemic stroke, both

218 hanisms of gene-environment interaction in a multifactorial model of a common birth defect.

219 ) is a common congenital malformation with a multifactorial model of inheritance.

220 A multifactorial model of white matter atrophy in focal ep

221 ditions were built using a minimal number of multifactorial modeling experiments (2 x 2 or 3 x 3 para

222 EG-VEGF provides potential insight into the multifactorial molecular mechanism by which dexamethason

223 methods to address clinical heterogeneity in multifactorial multi-ethnic disease settings.

224 Ascites syndrome is a hypertensive, multifactorial, multigene trait affecting meat-type chic

225 Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscul

226 AD remains incurable due to its complex and multifactorial nature and lack of effective diagnostics/

227 but it is also possible that their inherent multifactorial nature and their etiological and clinical

228 esign is a powerful strategy in tackling the multifactorial nature of Alzheimer's disease (AD).

229 of individual surface protein genes and the multifactorial nature of GAS-host interactions.

230 on) or that more comprehensively address the multifactorial nature of neurodevelopment may be require

231 Given the multifactorial nature of pain in patients with ALS, diff

232 about the etiology of PTB, likely due to the multifactorial nature of the disease.

233 Considering the disease's multifactorial nature, modulation of multiple targets mi

234 Due to its complex multifactorial nature, prediction is a challenge.

235 Glaucoma is a multifactorial neurodegenerative disorder and one of the

236 Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with important

237 Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder that encompas

238 s a resource for post-GWAS interpretation of multifactorial ocular traits.

239 Herein, we report the multifactorial optimization of high-throughput screening

240 g attention in the fight against diseases of multifactorial origin, such as neurodegenerative conditi

241 We describe the multifactorial origins of catalysis by the twister riboz

242 Advances in the understanding of the multifactorial origins of gait changes in patients with

243 This study identifies complex and multifactorial origins of ventral wall defects and has i

244 esults support the importance of the dynamic multifactorial paracrine signals in mediating remedial e

245 on in patients with Cushing's syndrome has a multifactorial pathogenesis and contributes to the incre

246 ieving symptoms associated with the complex, multifactorial pathogenesis of CIU/CSU.

247 link between AAV integration events and the multifactorial pathogenesis of HCC.

248 ronic rhinosinusitis (CRS) has a complex and multifactorial pathogenesis with a heterogeneous inflamm

249 Due to its worldwide distribution and multifactorial pathogenic mechanisms, COVID-19 poses a g

250 achieve robust therapeutic efficacy in this multifactorial pathology, combined peripheral PPARdelta-

251 jury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot ye

252 ucing a simple and practical technique named multifactorial peak crossover (MPC) via computer-assiste

253 Use of multifactorial preventive interventions for patients at

254 Ageing is a complex multifactorial process associated with a plethora of dis

255 nd animal models have revealed a complex and multifactorial process culminating in dysregulation of M

256 ter aortic valve replacement thrombosis is a multifactorial process involving foreign materials, pati

257 neumococcal phase variation is a complex and multifactorial process leading to strain-specific pathog

258 The formation of infection stones is a multifactorial process that can be driven by urine chemi

259 s of influenza A virus (IAV) infections is a multifactorial process that includes the replication cap

260 Cellular aging is a multifactorial process that is characterized by a declin

261 Sarcopenia is a complex multifactorial process, some of which involves fat infil

262 mical mechanisms underlying the overlapping, multifactorial processes that occur at the tumor-vascula

263 Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and

264 y of this technology in performing a complex multifactorial proteomic study of interactions between n

265 an tranplants because of several complex and multifactorial reasons; one area that could have a subst

266 lation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscl

267 sed to culprit drugs suggesting a nonlinear, multifactorial relationship in which HLA risk alleles ar

268 inal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in he

269 dual level, identification of people at high multifactorial risk and guideline-driven management of h

270 Multifactorial risk factors contributing to neurodevelop

271 In the setting of multifactorial risk reduction with statins and other lip

272 that BDNF plays a hitherto under-recognized multifactorial role as both a regulator and target of st

273 is well understood, less is known about its multifactorial role in the brain.

274 and discuss the current understanding of the multifactorial role of SynGAP in regulating neuronal fun

275 We developed and validated a parsimonious multifactorial score for the prediction of work disabili

276 We call for additional multifactorial studies that simultaneously manipulate mu

277 velopmental functions - pilus biogenesis and multifactorial swarming motility - while shaping distinc

278 Cancer cachexia is a multifactorial syndrome characterized by a progressive l

279 Cancer cachexia is a multifactorial syndrome characterized by anorexia, body

280 Cancer cachexia is a multifactorial syndrome characterized by body weight los

281 ental factors contributing to the "massively multifactorial system networks" which go awry in mental

282 Our data provide insights into the multifactorial Tbx3-dependent transcriptional network th

283 A multifactorial [temperature (40, 50 and 60 degrees C), h

284 nature of malpractice claims is complex and multifactorial, the identification and modification of n

285 complex disease, becomes more effective by a multifactorial therapeutic approach upon mobilization of

286 While this rise is likely multifactorial, there has been scarce consideration of t

287 Patients with cirrhosis exhibit multifactorial thrombocytopenia and in vitro thrombocyto

288 o routine diabetes care (n=176) or intensive multifactorial treatment (n=167).

289 diabetes, or screening followed by intensive multifactorial treatment.

290 ificial-intelligence-based methods that seek multifactorial trends rather than foundational principle

291 Given the multifactorial vascular effects of diabetes, we hypothes

292 The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancr

293 The pathogenesis of perioperative stroke is multifactorial, which makes prediction and prevention ch

294 However, psychiatric disorders are highly multifactorial with a wide diversity of risk factors spr

295 ly 10% of births worldwide; the aetiology is multifactorial with intra-amniotic infection being one c

296 earch suggests that the etiology of nsCPO is multifactorial, with a clear genetic component.

297 Susceptibility to SLE is multifactorial, with a combination of genetic and enviro

298 The etiology of MS is multifactorial, with disease risk determined by genetics

299 Underlying phenotypes and mechanisms are multifactorial, with no specific treatments at this time

300 The etiology of nonadherence is multifactorial, with the strongest risk factors includin