ライフサイエンスコーパス: multifunctional

1 ation, suggesting these RNA-capsid sites are multifunctional.

2 forms that are highly tunable and inherently multifunctional.

3 Herein, multifunctional active-center-transferable heterostructu

4 Thus, the multifunctional activity of p190RhoGAP emerges from its

5 in 1 knockout mice, implying that arrestins, multifunctional adapter and signaling proteins, play a v

6 The data suggest that EmaA is a multifunctional adhesin that utilizes different mechanis

7 d, which, in the case of reactions involving multifunctional aldehydes and primary amines, allow the

8 These data point to the multifunctional and critical role of the stroma in tumor

9 patient samples and their ability to induce multifunctional and cytotoxic antigen-specific T cells d

10 othelial cell protein C receptor (EPCR) is a multifunctional and multiligand receptor, which is expre

11 As sensitive multifunctional and multimodal imaging tracers, carbon-c

12 omponents outlines feasible pathways towards multifunctional and multimodal sensor platforms.

13 ) capped with metal nanoparticles (NPs) show multifunctional and synergistic properties, which are im

14 Phlorotannin extracts exhibited multifunctional antioxidant properties, which were sugge

15 tomizability makes them ideal candidates for multifunctional applications.

16 nversion, near-infrared detection, and other multifunctional applications.

17 Multifunctional autoprocessing repeats-in-toxin (MARTX)

18 The multifunctional autoprocessing repeats-in-toxins (MARTX)

19 Therefore, a multifunctional bacterial membrane-coated nanoparticle (

20 For example, multifunctional beta-arrestin (ARRB) adapter proteins ar

21 dy shows that the application of okara for a multifunctional beverage could be a promising strategy i

22 Herein, a multifunctional bio-nanocomposite comprised largely of e

23 traints can be re-examined in the context of multifunctional, bio-inspired applications.

24 een studied over the past decades, revealing multifunctional bioactive proteins targeting the host's

25 dy, we demonstrate the in situ assessment of multifunctional biodegradable nanoparticle (NP) entries

26 ield may give rise to the next generation of multifunctional biodevices, particularly with Industry 4

27 ave been the subject of immense advancement, multifunctional bioinks have received less attention.

28 dvances in the development of GQDs as novel, multifunctional biomaterials are presented with a focus

29 flux enhancement accomplished with our novel multifunctional biomimetic nanoparticles provides a new

30 spects and can inspire innovative designs of multifunctional, biomimetic pressure-sensitive adhesives

31 his work reports tunable piezoelectricity of multifunctional BNNT/PDMS stretchable composites prepare

32 Because Nav1.6 and the multifunctional Ca(2+)/CaM-dependent protein kinase II (

33 The multifunctional capabilities of this protein-tagging sys

34 ropylene glycol and glycerol often generates multifunctional carbonyls that are challenging to quanti

35 The development of a multifunctional catalyst, which mimics the promiscuity o

36 The rational design of multifunctional catalysts that use non-noble metals to f

37 and synergy between distinct active sites in multifunctional catalysts.

38 The multifunctional CCHFV nucleocapsid protein (N protein) p

39 prime regimen induced more antigen-specific multifunctional CD4 and CD8 T cells to the lung parenchy

40 T and R+ groups, and lower for the AP group; multifunctional CD4 responses were similar across all gr

41 st and sustained Th1-biased antigen-specific multifunctional CD4(+) T-cell responses up to 16 weeks p

42 Multifunctional CD8 and CD4 T-cell responses to pp65 wer

43 bsets and lower frequencies of HCMV-specific multifunctional CD8 T cells.

44 ated with the development of greater nAb and multifunctional CD8 T-cell responses compared with AP, p

45 gG antibody responses in a protective range, multifunctional CD8(+) and CD4(+) T cell responses with

46 issemination, and predict a crucial role for multifunctional CD8+ T cells and macrophage dynamics for

47 3 (SCUBE3) is a member of a small family of multifunctional cell surface-anchored glycoproteins func

48 e bone healing, present study aims to design multifunctional cell therapy microcarriers with the capa

49 Astroglia are multifunctional cells that regulate neuroinflammation an

50 Interestingly, after in vitro stimulation, multifunctional cells were more abundant among T cells o

51 Pericytes are multifunctional cells wrapped around endothelial cells v

52 those producing more than one cytokine (i.e. multifunctional cells).

53 roximity capture (CAP-C), a method that uses multifunctional chemical crosslinkers with defined sizes

54 ract with one of the receptors are favorable multifunctional chemical entities to treat or decelerate

55 This approach utilizes a bioorthogonal, multifunctional chemical probe that can be targeted to a

56 A novel multifunctional chemical proteomics probe was introduced

57 ) should serve as an attractive platform for multifunctional chronic neural implants.

58 CDON is a multifunctional co-receptor, including for the HH pathwa

59 e adaptable nature of J proteins to evolve a multifunctional cochaperone that functions with Hsc70 to

60 e adaptable nature of J proteins to evolve a multifunctional cochaperone that functions with Hsc70 to

61 ovides an additional handle for constructing multifunctional COFs and extending the range of their po

62 ave characteristics can be applied to design multifunctional composites via inverse techniques.

63 ighly stretchable, mechanically robust, soft multifunctional composites with high thermal stability(1

64 e starting materials for the construction of multifunctional compounds and challenging architectures

65 ost materials, such as paper, carbon ink and multifunctional connector headers.

66 t such approaches can enable the creation of multifunctional constructs and devices that cannot be fa

67 re sticky amino acids than IDRs of their non-multifunctional counterparts, or the surfaces of structu

68 a promising platform for the development of multifunctional crystalline materials.

69 roactive and conductive multidimensional and multifunctional crystalline porous materials.

70 hesion establishment factors," including the multifunctional Ctf18-RFC complex, aid this process in a

71 olorectal cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor

72 Bone morphogenetic proteins (BMPs) are multifunctional cytokines of the transforming growth fac

73 This multifunctional device also has a superior convective he

74 g structures and devices, metamaterials, and multifunctional devices with multiphysics responses.

75 nterrogation approaches rely on flexible and multifunctional devices.

76 for a wide range of memory, spintronic, and multifunctional devices.

77 CCP maturation that is consistent with GAK's multifunctional domain architecture.

78 Rep proteins contain two multifunctional domains: an Origin Binding Domain (OBD)

79 uated the effect of a brain-penetrant, novel multifunctional dopamine D2/D3 agonist, D-520 on the inh

80 myloid functions as promising candidates for multifunctional drugs.

81 Herein, a multifunctional dual-modal imaging probe is successfully

82 MUL1 is a multifunctional E3 ubiquitin ligase anchored in the oute

83 ites are ideally suited to achieve desirable multifunctional effective properties since the best prop

84 Compared to higher frequencies of multifunctional effector memory CD8(+) T(EM) cells in AS

85 itrogen reduction reaction, and bifunctional/multifunctional electrocatalysis, along with some challe

86 for non-noble bimetallic nanostructures with multifunctional electrocatalytic properties.

87 Thus, Repeat B is a multifunctional element that integrates interdependent X

88 recruiting sorting nexin 9 (SNX9), a central multifunctional endocytic scaffold protein.

89 T. cruzi calreticulin (TcCalr) is a multifunctional, endoplasmic reticulum (ER)-resident cha

90 es and ferroelectric perovskites) for future multifunctional energy conversion and storage devices is

91 celerated development in the construction of multifunctional energy generation and storage systems th

92 ally interacted with TFP, thereby creating a multifunctional energy protein complex.

93 que features of RNA synthesis, the monomeric multifunctional enzyme L, and the oligomeric multimodula

94 from mice immunized with a vaccine target, a multifunctional enzyme or a membrane-bound cancer target

95 Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme that processes DNA intermediates

96 Because of their special organization, multifunctional enzymes play crucial roles in improving

97 Therefore, the multifunctional feature of MDSCs make them attractive im

98 l coverage of brain tissue through multisite multifunctional fiber-based neural probes guided in a he

99 offers a platform for advanced adaptive and multifunctional flat optics with merits of high compactn

100 corporate these fiber-shaped electrodes into multifunctional FSESDs, including fiber-shaped supercapa

101 marily responsible for the high affinity and multifunctional GBT uptake systems observed in seawater.

102 Here, multifunctional glycol CNPs designed to overcome multipl

103 Cluster of differentiation 147 (CD147) is a multifunctional glycoprotein that functions as an induce

104 BMPs are multifunctional growth factors implicated in regulating

105 We herein report our new generation of multifunctional HDAC6 degraders by tethering selective H

106 potential use of MOLs in constructing novel multifunctional heterogeneous catalysts.

107 d from body-worn fitness tracking devices to multifunctional, highly integrated, compact, and versati

108 The multifunctional host-defence peptides (HDPs) cathelicidi

109 Frequent multifunctional HSV-specific effector memory CD62L(low)

110 Frequent multifunctional HSV-specific effector memory CD8(+) T(EM

111 hlight the pivotal role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell develo

112 We report the design and preparation of multifunctional hybrid nanomaterials through the stabili

113 constants and being among the most abundant multifunctional hydroperoxides, they are among the most

114 developed approach was applied to concurrent multifunctional imaging in phantom samples and in vivo i

115 n HSV-1 infection.IMPORTANCE HSV-1 ICP0 is a multifunctional immediate early protein key to effective

116 Mast cells are multifunctional immune cells that are found most abundan

117 vation of procaspase-8, we define pUL36 as a multifunctional inhibitor of both apoptotic and necropto

118 anomaterials hold great promise in designing multifunctional intelligent devices for a wide range of

119 Modern robots lack the multifunctional interconnected systems found in living o

120 osing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein,

121 glycine receptor alpha1 subunit represents a multifunctional intracellular protein motif.

122 One role of the multifunctional KCNQ C terminus is to mediate subtype-sp

123 U(S)3 encoded by alphaherpesviruses is a multifunctional kinase involved in the regulation of var

124 ally indirect interfacial absorption, making multifunctional layered core-shell structures attractive

125 that other FGFs may be membrane tethered or multifunctional like Pyr.

126 phospholipid biosynthetic intermediate and a multifunctional lipid second messenger produced at sever

127 Herein, we report a multifunctional liposomal system (164.6 +/- 5.3 nm in di

128 he nano-sized, activated-platelet-sensitive, multifunctional liposomes could facilitate selective del

129 The analytical capabilities of BzPy as a multifunctional MALDI-MSI matrix are demonstrated by ima

130 Silicon germanium (SiGe) is a multifunctional material considered for quantum computin

131 d attenuation coefficients, which facilitate multifunctional material design.

132 e the potential for transformative impact in multifunctional material engineering.

133 Molybdenum disulfide (MoS(2) ) is a multifunctional material that can be used for various ap

134 The support allows the production of a multifunctional material with mouldable shape and potent

135 is concept critically expands the breadth of multifunctional materials attainable by self-assembly.

136 re, the bright potential of HOF materials as multifunctional materials is highlighted in some of the

137 , and changing, which rely on innovations in multifunctional materials, distributed actuation and sen

138 n be obtained, opening avenues for designing multifunctional materials.

139 ties and their combinations towards advanced multifunctional materials.

140 ral rotation and opens avenues for designing multifunctional materials.

141 ing research interest as a new generation of multifunctional materials.

142 In this work, we identify a multifunctional matrix-assisted laser desorption/ionizat

143 idic cluster sorting protein-1 (PACS-1) is a multifunctional membrane traffic regulator that plays im

144 This study paves a pathway for the design of multifunctional metal-organic framework systems as a use

145 We report the design of a new multifunctional metal-organic layer (MOL), Hf(12)-Ir-OTf

146 CNF composite for developing next-generation multifunctional microelectrodes for applications in neur

147 and magnetic nanoparticles (NPs) to realize multifunctional microrobotic structures and demonstrate

148 Tau is a multifunctional microtubule-associated protein in the ne

149 One emerging area is the discovery of multifunctional molecules that act at two or more pharma

150 A multifunctional motile microtrap is developed that is ca

151 lled HSET or kinesin-14a) is best known as a multifunctional motor protein essential for mitosis.

152 Multifunctional nanocarriers (MNCs) promise to improve t

153 Therefore, NLCs act as safe multifunctional nanocarriers, overcome efficacy and spec

154 ategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain struct

155 advancements in nanotechnology have created multifunctional nanomaterials aimed at enhancing diagnos

156 erapeutic strategies targeting the TME using multifunctional nanomedicines hold great potential for a

157 neered biomimetic nanocarrier in SHH MB, our multifunctional nanoparticle provides intriguing therape

158 The preparation and characterization of the multifunctional nanoparticles takes ~10 h for tumor-asso

159 Smart multifunctional nanoparticles with magnetic and plasmoni

160 ancer chemotherapy could be reduced by using multifunctional nanoplatforms.

161 ene group containing substrates that affords multifunctional naphthalenes, phenanthrenes, quinolines,

162 This multifunctional nature allows BrC to be water-soluble an

163 Selective interfacing to small multifunctional nerves such as the vagus nerve (VN) whic

164 way towards innovative high-performance and multifunctional neuro-probes.

165 materials science, nanomedicine and biology, multifunctional NIR-II photothermal inorganic or organic

166 The neonicotinoid nitenpyram (NPM) is a multifunctional nitroenamine [(R(1)N)(R(2)N)C=CHNO(2)] p

167 e findings highlight the unique chemistry of multifunctional nitroenamines and demonstrate that known

168 Moreover, multifunctional NMs synergize surgery with adjuvant ther

169 The viral multifunctional NS1 protein inhibits host antiviral resp

170 NKAP is a multifunctional nuclear protein that associates with the

171 erial for the production of programmable and multifunctional objects.

172 Herein, we report the development of multifunctional on-skin electronics, which can passively

173 The flight muscle is an essential multifunctional organ, mediating a large range of functi

174 Peroxisomes are multifunctional organelles with roles in cellular metabo

175 This is the first example of a multifunctional organic cage capable of sensing, directi

176 generalizability of directly incorporating a multifunctional organic semiconductor that both extends

177 this work reveals a bacterial GEF within the multifunctional OtDUB that co-opts host Rac1 signaling t

178 Coronaviruses express a multifunctional papain-like protease, termed papain-like

179 onal ADP-ribosylation of proteins, and viral multifunctional papain-like proteases, enzymes that clea

180 Biosensors engineered with the proposed multifunctional particles were able to detect the sepsis

181 Herein, a modular and versatile approach to multifunctional peptide-based vaccine platforms at multi

182 ucing strong Th17 responses in the lungs and multifunctional peripheral T-lymphocytes.

183 rapy using self-assembled nanoparticles of a multifunctional pH-sensitive amino lipid ECO and a thera

184 g building blocks for constructing synthetic multifunctional photonic structures owing to their renew

185 on activity, thus expanding the roles of the multifunctional PIF-signaling hub.

186 Cytokinins are mobile multifunctional plant hormones with roles in development

187 ch safeguards the expression of an essential multifunctional plant stress regulator.

188 This novel designed DOS molecule provides a multifunctional platform for detection of volatile organ

189 l structure can be introduced as a promising multifunctional platform for local therapy of breast can

190 Sst neurons and suggest that these cells are multifunctional players in the midbrain reward circuitry

191 Emerging as a relatively new class of multifunctional porous materials, metal-organic framewor

192 as a highly versatile platform for exploring multifunctional porous materials.

193 us bacteriophage M13, forms a 3D large-scale multifunctional porous structure by self-assembly, with

194 This multifunctional potential is achieved through alternativ

195 etween virus and host proteins involving the multifunctional PPxY-containing adaptor Amot, which regu

196 Angiomotin (Amot) is a multifunctional PPxY-containing adaptor protein that reg

197 o a functional shift from a homeostatic to a multifunctional proinflammatory state.

198 Proteases are multifunctional, promiscuous enzymes that degrade protei

199 laxor, understanding the exact nature of its multifunctional properties has remained a challenge for

200 st abundant epoxygenase in the heart and has multifunctional properties including bioactivation of ar

201 drives multiple song types, suggesting that multifunctional properties of song circuits may facilita

202 artificial organisms can have unprecedented multifunctional properties, like wireless activation of

203 Equipped with a better knowledge of SOICs' multifunctional properties, researchers have made consid

204 d herpesvirus protein kinase (CHPK) that has multifunctional properties.

205 minoacyl tRNA synthetase complex interacting multifunctional protein 2 with increased parkin interact

206 DJ-1 is a multifunctional protein affecting different biological a

207 results shed light on the regulation of this multifunctional protein and may inform the design of the

208 The engineered multifunctional protein C2C was tested for control of se

209 Munc13-1 is a large multifunctional protein essential for synaptic vesicle f

210 rus (HCV) nonstructural protein 2 (NS2) is a multifunctional protein implicated in both HCV RNA repli

211 (SMN) genes that code for SMN, an essential multifunctional protein in humans.

212 We have found that BRCA1, a multifunctional protein involved in DNA repair and epige

213 CaMKIV is a multifunctional protein kinase associated with inflammat

214 Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a multifunctional protein that has been implicated in a my

215 Cytochrome c (Cytc) is a multifunctional protein that operates as an electron car

216 known as non-LTR retrotransposons, encode a multifunctional protein that reverse transcribes its mRN

217 Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron

218 Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET rec

219 antly expressed protein during latency, is a multifunctional protein which is absolutely required for

220 igment epithelium-derived factor (PEDF) is a multifunctional protein which was initially described in

221 romatin-associated, vertebrate-specific, and multifunctional protein with a role in DNA damage signal

222 The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar localiz

223 PRRSV helicase nsp10 is a multifunctional protein with translocation and unwinding

224 The multifunctional protein Y-box binding protein 1 (YBX1),

225 ny cases, how inhibiting only a portion of a multifunctional protein's functions affects the state of

226 Here we show that HNRNPK, a multifunctional protein, is necessary to prevent prematu

227 Because it is a multifunctional protein, SFRP1 targeting serves as a pot

228 S100A9 is one such multifunctional protein.

229 Multifunctional proteins are evolutionary puzzles: how d

230 s to phosphorylation of GPCRs and binding to multifunctional proteins called beta-arrestins (betaarrs

231 or of G protein signaling (RGS) proteins are multifunctional proteins expressed in peripheral and neu

232 Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological p

233 ue inhibitors of metalloproteinases (TIMPs), multifunctional proteins that all inhibit members of the

234 viruses employ a genetic economy by encoding multifunctional proteins that function in viral replicat

235 ted sodium channel (VGSC) beta1 subunits are multifunctional proteins that modulate the biophysical p

236 ke would be of great utility, especially for multifunctional proteins.

237 In sum, this multifunctional proteolytic system has emerged as a regu

238 We describe multifunctional proteolytic systems that target N-degron

239 Here, we assembled a multifunctional prototype DNA nanodevice, DOCTR, that re

240 We conclude that TASOR is a multifunctional pseudo-PARP that directs HUSH assembly a

241 N,N-Dimethylanilines are multifunctional reaction partners and represent useful b

242 We report the development of a multifunctional reagent for the direct conversion of pyr

243 ate that the divergent signaling output from multifunctional receptor complexes critically depends on

244 d propose ways in which combinatorial use of multifunctional recognition molecules enables the comple

245 eport a biologically inspired dual-targeting multifunctional recombinant high-density lipoprotein (rH

246 HCV NS2 protein is a multifunctional regulator of HCV replication involved in

247 e a major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for ooc

248 To find out whether multifunctional responses associate with protection in o

249 llers had greater diversity of HCMV-specific multifunctional responses at both time points, including

250 f their eukaryotic counterparts by utilizing multifunctional RNA polymerases to replicate entire vira

251 Counteracting this mechanism, the multifunctional RNA-binding protein PTBP1 regulates the

252 ctor 2 mRNA-binding protein 1 (IGF2BP1) is a multifunctional RNA-binding protein with an oncofetal pa

253 RSV RNA synthesis is catalyzed by a multifunctional RNA-dependent RNA polymerase (RdRP), whi

254 ructural flexibility required to fulfill its multifunctional role during the AAV life cycle.

255 sin II in regulating burst occurrence, and a multifunctional role for the rosette structure in activi

256 Although mitochondria play a multifunctional role in cancer progression and Ca(2+) si

257 Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo s

258 Elucidating the multifunctional roles of PS receptors in virus-host inte

259 e of genes in different contexts, leading to multifunctional roles of signaling factors during develo

260 Disabled-2 (Dab2) is a multifunctional scaffold protein frequently downregulate

261 xtiles with mechanical energy harvesting and multifunctional self-powered sensing capabilities, while

262 A multifunctional sensor capable of simultaneous sensing o

263 to meet the growing demands of the advanced multifunctional sensors and biosensors.

264 ce both a neutralizing antibody response and multifunctional SFTSV-specific T cell response in mice a

265 The integrated multifunctional shape manipulations are further exploite

266 mable soft materials that exhibit integrated multifunctional shape manipulations, including reprogram

267 ll adaptor protein (BCAP) is a multimodular, multifunctional signal transducer that regulates signal

268 Collectively, CD3epsilon is a built-in multifunctional signal tuner, and increasing CD3 diversi

269 at connective tissue growth factor (CTGF), a multifunctional signaling modulator, promotes cancer ini

270 Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern form

271 RGS14 is a multifunctional signaling protein that suppresses synapt

272 inated/embedded on/into elastomers, yielding multifunctional single-sensing resistors as well as full

273 lectronics can serve as the basis for future multifunctional smart textiles with passive-cooling func

274 le properties utilized in the development of multifunctional SOICs will provide a forum for future ad

275 strating a promising application of GCl as a multifunctional solid additive in the field of OSCs.

276 raphdiyne (GCl) is successfully applied as a multifunctional solid additive to fine-tune the morpholo

277 sing photoswitchable MOFs in next-generation multifunctional stimuli-responsive materials while highl

278 This is the first demonstration of multifunctional, stretchable BNNT/PDMS composites with e

279 Lysosomes are multifunctional, subcellular organelles with roles in pl

280 e peptide-based catalysts have enabled novel multifunctional substrate activation modes and unprecede

281 This approach provides greater insight into multifunctional sutures with inherent sensing capabiliti

282 ctions and opens an avenue to create COFs as multifunctional systems.

283 p65)- and immediate early protein 1-specific multifunctional T-cell responses were determined by mean

284 nting chlamydia immunopathology, whereas the multifunctional Tc1 clone did not enhance clearance or s

285 SARS-CoV-2-specific T cells were less multifunctional than influenza-specific T cells, particu

286 demonstrating that secondary metabolites are multifunctional; they can function as potent regulators

287 in recent years in the arena of fabricating multifunctional, three-dimensional (3D) tissue construct

288 We propose a simplified multifunctional traffic control approach that effectivel

289 Upstream activation factor (UAF) is a multifunctional transcription factor in Saccharomyces ce

290 MYC oncoprotein is a multifunctional transcription factor that regulates the

291 criptional repressor by interacting with the multifunctional transcription factor Yin Yang 1 (YY1) an

292 taining protein 2 (BRD2), BRD3, and BRD4 are multifunctional transcriptional regulators that bind ace

293 d RNAs (dsRNAs), the exceptionally abundant, multifunctional VA RNAs sabotage host machineries that s

294 We identify a multifunctional variant within the TBC1D4 gene encoding

295 of fatty acids-than FASs with only a single multifunctional version of each enzyme (i.e., one enzyme

296 tinct extracellular substrates and support a multifunctional view of the role of extracellular electr

297 35-nm diameter "crown" complex that contains multifunctional viral RNA replication protein A.

298 We have evidence that the multifunctional viral translation transactivator/viropla

299 al of 181 proteins co-purifying with a Venus multifunctional (VM)-tagged CK1delta and/or CK1epsilon.

300 There exist five multifunctional yet structurally and biosynthetically in