ライフサイエンスコーパス: multifunctional enzyme

1 tion may be an important determinant of this multifunctional enzyme.

2 nal events is proposed to help regulate this multifunctional enzyme.

3 Human tissue transglutaminase (hTG2) is a multifunctional enzyme.

4 n that has been excised from the full-length multifunctional enzyme.

5 somerase (hPDI), is an essential four-domain multifunctional enzyme.

6 mine transaminase K (hKAT-I) is an important multifunctional enzyme.

7 n the SCP-2-like domain from the peroxisomal multifunctional enzyme.

8 the structure/function correlations of this multifunctional enzyme.

9 illustrate the limits to modularity of these multifunctional enzymes.

10 e-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes.

11 to function as a scaffold protein for three multifunctional enzymes.

12 nd the fact that some of the potent MMPs are multifunctional enzymes.

13 Metabolite channeling is a common feature of multifunctional enzymes.

14 s characterization of activities mediated by multifunctional enzymes.

15 te- and stereo-selectivity of this family of multifunctional enzymes.

16 hondria, whereas peroxisomes contain ECI and multifunctional enzyme 1 (MFE1).

17 the NH2-terminal domain of the multidomain, multifunctional enzyme, 10-formyltetrahydrofolate dehydr

18 A novel target is the multifunctional enzyme acetyl-CoA carboxylase (ACC), whi

19 n debranching enzyme (gene symbol, AGL) is a multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-

20 This multifunctional enzyme also has inositol 3,4,5,6-tetraki

21 like all members of the cyclase family, is a multifunctional enzyme and catalyzes NAD(+) glycohydrola

22 ostulate the domain organization of a set of multifunctional enzymes and a cluster of genes (pps) tha

23 vitro assays indicate that LAP5 and LAP6 are multifunctional enzymes and may play a role in both the

24 he human SCHAD gene product, a single-domain multifunctional enzyme, appears to function in two diffe

25 The multifunctional enzyme apurinic endonuclease 1/redox enh

26 t the comparatively weak activities of these multifunctional enzymes are each physiologically relevan

27 These large multifunctional enzymes are organized into "modules", wh

28 in modifier, and transglutaminase 2 (TG2), a multifunctional enzyme, are known to be activated during

29 rovide specificity in the activation of this multifunctional enzyme by distinct cellular stimuli and

30 l phosphate synthetase (CPS II), part of the multifunctional enzyme CAD.

31 ny polyketides are synthesized by a class of multifunctional enzymes called type I modular polyketide

32 Alternative targeting of bifunctional or multifunctional enzymes can exploit eukaryotic subcellul

33 tive enzymes, broad-specificity enzymes, and multifunctional enzymes can often substitute for a missi

34 tissues are primarily controlled by CD38, a multifunctional enzyme capable of both synthesizing and

35 CD38 is a multifunctional enzyme capable of generating metabolites

36 Biotin-dependent multifunctional enzymes carry out metabolically importan

37 L is a multifunctional enzyme carrying out RNA-dependent RNA po

38 dent enzymes and presents a new paradigm for multifunctional enzyme catalysis.

39 RNA-dependent RNA polymerase (RdRp) is a multifunctional enzyme catalyzing genome replication as

40 1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme catalyzing regio- and stereospeci

41 among which fatty acid synthase (FASN), the multifunctional enzyme catalyzing the de novo synthesis

42 nctions not only as a receptor but also as a multifunctional enzyme,catalyzing the synthesis of and h

43 decreased levels of the apoptosis-associated multifunctional enzyme CD38.

44 Its synthesis is catalyzed by multifunctional enzymes, CD38 and ADP-ribosyl cyclase (c

45 ridoxal 5'-phosphate (PLP) is a fundamental, multifunctional enzyme cofactor used to catalyze a wide

46 xyerythronolide B synthase (DEBS), are large multifunctional enzyme complexes that are organized into

47 LigD is a multifunctional enzyme composed of a ligase domain fused

48 LigD is a multifunctional enzyme composed of a ligase domain fused

49 ACC is a multifunctional enzyme composed of three separate protei

50 alyzed by individual monofunctional enzymes, multifunctional enzymes comprising several domains, or e

51 The Escherichia coli form is a multifunctional enzyme consisting of three separate prot

52 ulin-dependent protein kinase II (CaMKII), a multifunctional enzyme critically involved in synaptic p

53 report a chemosynthetic route relying on the multifunctional enzyme CrpD-M2 that incorporates a 2-hyd

54 encing (RISC) complex requires the essential multifunctional enzyme Dicer.

55 trates the evolutionary conservation of this multifunctional enzyme family.

56 , an insulin-dependent process driven by the multifunctional enzyme fatty-acid synthase (FAS), mainta

57 CO-ED was designed to identify unannotated multifunctional enzymes for functional characterization

58 Dehaloperoxidase (DHP A), a unique multifunctional enzyme, from the marine annelid Amphitri

59 ew tools for manipulating and studying these multifunctional enzymes have been developed.

60 arge majority of histidine kinases (HKs) are multifunctional enzymes having autokinase, phosphotransf

61 Class II genes (AtTPS5-AtTPS11) encode multifunctional enzymes having synthase and phosphatase

62 Phospholipase Cepsilon (PLCepsilon) is a multifunctional enzyme implicated in cardiovascular, pan

63 est structural relatives of CblD are CblC, a multifunctional enzyme important for cobalamin trafficki

64 EJ are the most mechanistically flexible and multifunctional enzymes in each of their classes.

65 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activa

66 CD38 is a multifunctional enzyme involved in metabolizing two Ca(2

67 Tissue transglutaminase (TG2) is a multifunctional enzyme involved in protein cross-linking

68 nd drrA, which constitute an operon encoding multifunctional enzymes involved in the biosynthesis of

69 Cysteine proteases are multifunctional enzymes involved in vital metabolic proc

70 que features of RNA synthesis, the monomeric multifunctional enzyme L, and the oligomeric multimodula

71 arides to soluble sugars, many organisms use multifunctional enzyme mixtures consisting of glycoside

72 The multifunctional enzyme NSP2, an octamer with RNA binding

73 r signals that determine the turnover of the multifunctional enzyme nucleoside diphosphate kinase A (

74 'copy and paste' mechanism catalysed by its multifunctional enzyme, open reading frame 2 protein (OR

75 from mice immunized with a vaccine target, a multifunctional enzyme or a membrane-bound cancer target

76 cyte antigen and recently also found to be a multifunctional enzyme participating in the synthesis an

77 Because of their special organization, multifunctional enzymes play crucial roles in improving

78 Non-structural protein 3 (NS3) is a multifunctional enzyme possessing serine protease, NTPas

79 TDP2 is a multifunctional enzyme previously known for its role in

80 HIV-1 reverse transcriptase (HIV-1 RT) is a multifunctional enzyme responsible for converting viral

81 lly pine (Pinus taeda) xylem cDNA encoding a multifunctional enzyme, SAM:hydroxycinnamic Acids/hydrox

82 e little-considered role of some proteins as multifunctional enzymes - substitutes for 'missing' gene

83 we discuss several of nature's most notable multifunctional enzyme systems including the AROM comple

84 n (Pik) polyketide synthase (PKS) are unique multifunctional enzyme systems that are responsible for

85 new model for molecular dissection of these multifunctional enzyme systems.

86 Here, we provide evidence that CYP76C1 is a multifunctional enzyme that catalyzes a cascade of oxida

87 human immunodeficiency virus-1 (HIV-1) is a multifunctional enzyme that catalyzes the conversion of

88 homocysteine nucleosidase (MTAN) enzyme is a multifunctional enzyme that catalyzes the hydrolysis of

89 Aldose reductase (AR) is a multifunctional enzyme that catalyzes the reduction of g

90 A single gene (mas) encodes the multifunctional enzyme that catalyzes the synthesis of v

91 I) is one of the glycolytic enzymes and is a multifunctional enzyme that functions in glucose metabol

92 ehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that has been associated with neu

93 Transglutaminase 2 (TG2) is a multifunctional enzyme that has been implicated in the p

94 in-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is postulated to be the down

95 in-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synapti

96 YfcX is shown to be a multifunctional enzyme that minimally encodes hydratase

97 RecBCD is a multifunctional enzyme that possesses both helicase and

98 Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme that processes DNA intermediates

99 We conclude that HydG is a multifunctional enzyme that produces DHG, CN(-), and CO

100 Aldose reductase (AR) is a multifunctional enzyme that reduces aldehydes.

101 Sirt6 is a multifunctional enzyme that regulates diverse cellular p

102 n fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid.

103 Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules,

104 Modular polyketide synthases are giant multifunctional enzymes that catalyse the condensation o

105 Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic pro

106 They are key, multifunctional enzymes that have been linked to three h

107 Thiol isomerases are multifunctional enzymes that influence protein structure

108 ng iterative polyketide synthases are large, multifunctional enzymes that make important metabolites

109 Hepadnavirus polymerases are multifunctional enzymes that play critical roles during

110 thione S-transferases (GSTs) are a family of multifunctional enzymes that play critical roles in the

111 ative polyketide synthases (PKSs) are large, multifunctional enzymes that resemble eukaryotic fatty a

112 e I polyketide synthases (PKSs) are complex, multifunctional enzymes that synthesize structurally div

113 3 provides a platform for generating bespoke multifunctional enzymes that target industrially signifi

114 ic gramicidin S is accomplished by two large multifunctional enzymes, the peptide synthetases 1 and 2

115 The multifunctional enzyme transglutaminase 2 (TG2) is the t

116 Previous studies have established that multifunctional enzymes use methylmalonyl coenzyme A (Co

117 ber of a newly defined family of prokaryotic multifunctional enzymes, which includes the Escherichia

118 The Dna2 protein is a multifunctional enzyme with 5'-3' DNA helicase, DNA-depe

119 al NS3 protein of the hepatitis C virus is a multifunctional enzyme with an N-terminal serine proteas

120 onuclease of human cells, Ape1 protein, is a multifunctional enzyme with critical roles in base excis

121 Protein phosphatase 1 (PP1) is a multifunctional enzyme with diverse roles in the nervous

122 The P gene product is believed to be a multifunctional enzyme with DNA-dependent DNA polymerase

123 that it encodes LH3, a myotomally expressed multifunctional enzyme with lysyl hydroxylase and glycos

124 rus (HCV) nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-b

125 V) nonstructural 3 protein (NS3) is a 70-kDa multifunctional enzyme with three known catalytic activi

126 Tissue transglutaminase (tTG) is a multifunctional enzyme with transglutaminase crosslinkin

127 Bacterial chondroitin polymerase K4CP is a multifunctional enzyme with two active sites.