ライフサイエンスコーパス: multigene

1 terconnected gene sets on the basis of their multigene 3D interactions.

2 pendent populations has been used to develop multigene algorithms for estimating recurrence risk and

3 rouracil (FU) and leucovorin (LV) to develop multigene algorithms to quantify the risk of recurrence

4 Coordinate regulation of a multigene alpha-KG synthesis and transport pathway resul

5 Products of the multigene alpha-zein families and the single-gene gamma-

6 An associated multigene analysis enabled us to infer the nature of sel

7 Here, using multigene and genome-based data, we assemble a 5,284-spe

8 molecules, plant transformation with linked multigenes and plant artificial chromosomes.

9 that marker status to other treatments (eg, multigene assay and breast cancer).

10 of the MR radiomics features relative to the multigene assay classifications.

11 [RS]) categories of a commercially available multigene assay influences the power of randomized trial

12 P < .0001) between radiomics signatures and multigene assay recurrence scores.

13 otype DCIS Score is a commercially available multigene assay that has been independently validated in

14 netic resonance (MR) imaging phenotypes with multigene assays of MammaPrint, Oncotype DX, and PAM50 t

15 on a recent large dataset, multispecies, and multigene-based alignment.

16 Germline testing with multigene cancer panels should be considered for all you

17 to have occurred by tandem duplication of a multigene cassette that was not found in the mixed-strai

18 t baculovirus carrying a vector containing a multigene cassette was created to coexpress in insect ce

19 efficient assembly of bacterial marker free multigene cassettes containing up to six complementary D

20 To determine if a multigene classifier is associated with indolent behavio

21 lecular classification system and prognostic multigene classifiers based on microarrays or derivative

22 The human Growth Hormone (hGH) multigene cluster contains five gene paralogs.

23 to tissue-specific gene regulation within a multigene cluster.

24 Analogous multigene clusters also encode the immunodominant outer

25 Multigene clusters collectively upregulate in single aph

26 xpressed genes and DNA vaccines based on the multigene clusters have been shown to induce protective

27 ated gene editing for functional analysis of multigene clusters, and it provides a large array of new

28 y on the actions of the LCR, but also on the multigene composition of the cluster itself.

29 ntal specificity is dependent on the overall multigene configuration of the cluster whereas the dista

30 stably transformed, respectively, by several multigene constructs, and the expression of the transfor

31 and we show that it can be used to assemble multigene constructs.

32 e mechanisms through which highly penetrant, multigene copy number variants contribute to disease ris

33 Here, we use taxon-rich multigene data combined with diverse fossils and a relax

34 Here we estimate divergence times using a multigene data set with multiple fossil calibrations and

35 defects at the neuromuscular junction in the multigene deficiency strain were the likely basis of its

36 ous genes, which precludes the generation of multigene-deficient animals through standard interbreedi

37 utions, an intragenic deletion, and a 4.7-Mb multigene deletion involved the DNA-binding domain of IK

38 nfectious cycle, we screened a S Typhimurium multigene deletion library in Caco-2 C2Bbe1 and HeLa epi

39 uman homologue is a component of two related multigene deletion syndromes in humans.

40 ), in-frame indels, and deletions; 2) single/multigene deletion; and 3) movement of mobile genetic el

41 Multigene delivery and subsequent cellular expression is

42 Autism is currently considered a multigene disorder with epigenetic influences.

43 exes via coexpression of their subunits from multigene DNA constructs.

44 tegrative genetic elements (IGEs) are mobile multigene DNA units that integrate into and excise from

45 eotides a completely de-novo-designed, 58-kb multigene DNA.

46 etween teleosts and tetrapods and suggests a multigene duplication event.

47 s atrox) through a number of single gene and multigene duplication events.

48 nological advances in data mining, modeling, multigene engineering and genome editing are now taking

49 xample to establish principles of successful multigene engineering by stable transformation of the ch

50 ates fully exchangeable genetic elements for multigene engineering, the GB2.0 toolkit offers an everg

51 perimenter's choice of the best strategy for multigene engineering.

52 y protocols for GB2.0 part domestication and multigene engineering.

53 tegrative acceptor vector, and (2) transient multigene expression and repression systems using known

54 nough to allow the manual generation of many multigene expression constructs in parallel.

55 approach is challenging and inefficient for multigene expression due to increased labour for cloning

56 al oncogene effects to weak but quantifiable multigene expression effects.

57 system expediting highly efficient transient multigene expression from a variety of promoters.

58 Multigene expression is required for metabolic engineeri

59 Two measures of information based on multigene expression profiles are considered for a backw

60 By considering multigene expression profiles, we are able to utilize in

61 Using this approach, we demonstrated multigene expression profiling of individual CTCs from n

62 f 14 (TRIM14) as a component of a prognostic multigene expression signature for NSCLC.

63 pic changes in proteins and gene expression, multigene expression signatures based on sequencing tech

64 nd comparable to those of microarray-derived multigene expression signatures.

65 d, also by a one-step cloning, into a binary multigene expression vector for transient or stable coex

66 ast cancers are imperfect when compared with multigene expression-based assays.

67 A cargo capacity, thus impeding unrestricted multigene expression.

68 oteins, including members of three different multigene families (VIR, Pv-FAM-A, Pv-FAM-D), one membra

69 id transfer proteins (nsLTPs) are encoded by multigene families and possess physiological functions t

70 s an inherent property of highly polymorphic multigene families and that it cannot be taken as eviden

71 ral differences between divergent members of multigene families are functionally important.

72 Major repeat sequences and multigene families are largely free of DNA methylation.

73 Several multigene families encode RNA binding proteins (RNABPs)

74 Multigene families encoding class XI myosins are conserv

75 These findings suggest that novel multigene families encoding diversified immune receptors

76 ls large-scale duplication and divergence of multigene families encoding molecules that effect innate

77 ocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are express

78 able expression of individual members of the multigene families encoding these genes also occurs duri

79 eplication-dependent histones are encoded by multigene families found in several large clusters in th

80 Our phylogenetic analyses of 11 multigene families from five species belonging to distin

81 In mammals, small multigene families generate spliceosomal U snRNAs that a

82 es encoding PP2A subunits have expanded into multigene families in both flowering plants and mammals,

83 specific opportunities to target members of multigene families in crops.

84 ying genetic variation in homologous loci or multigene families in general.

85 Although present as multigene families in most species, the functional relev

86 unctional characterization of members of the multigene families in this model insect.

87 mb repressive complexes (PRC) are encoded by multigene families in vertebrates.

88 f tetrapods and bony fish and diversified as multigene families independently in the two lineages.

89 nctional dissection of different isoforms of multigene families involved in beta-oxidation.

90 est that representatives of the FcR and FCRL multigene families may have independently evolved to eng

91 Flowering plants have evolved multigene families of the class XI myosin motors, the fu

92 sis of homologous gene sequences either from multigene families or from different species with a spec

93 Plasmodium multigene families play a central role in the pathogenes

94 t species, the functional relevance of these multigene families remains largely undefined.

95 the extent of lateral transfer in bacterial multigene families should be re-examined in the light of

96 e vast majority (>95%) of DPs in these large multigene families still await discovery of their bioche

97 anisms that cause the concerted evolution of multigene families such as rDNA.

98 s linked to the variant expression of clonal multigene families such as the var genes.

99 s in TUBA1A and TUBB2B, each a member of the multigene families that encode alpha- and beta-tubulins,

100 Intriguingly, actinoporins appear as multigene families that give rise to many protein isofor

101 iant proteins pertaining to VIR and Pv-FAM-D multigene families were used.

102 e selected to present many peptides, through multigene families, allelic polymorphism, and peptide-bi

103 opsis thaliana), both enzymes are encoded by multigene families, having distinctive expression patter

104 he organization of most virulence-associated multigene families, including the hypervariable var gene

105 sed in a given culture condition in expanded multigene families, suggesting that family expansi on co

106 any metazoan splicing factors are members of multigene families, with each member having different fu

107 rs performed the best at aligning genes from multigene families-perhaps the most challenging test for

108 everal E3s have expanded in their genomes as multigene families.

109 ed by at least four evolutionarily unrelated multigene families.

110 ter GA biosynthetic stages being governed by multigene families.

111 lenging when the target genes are members of multigene families.

112 d to gene-rich regions that harbor clustered multigene families.

113 roles of the different members of these OMP multigene families.

114 to characterize a large number of eukaryotic multigene families.

115 ins of gap junctions are the products of two multigene families.

116 origination, diversification and loss within multigene families.

117 he japonica genome, 38 (76%) fell into eight multigene families.

118 ry receptor (Or) and gustatory receptor (Gr) multigene families.

119 ch step is executed by components encoded by multigene families.

120 mes, many of which are encoded by members of multigene families.

121 nce diversity, such as that seen in variable multigene families.

122 ain Georgia (ASFV-G) lacking only six of the multigene family 360 (MGF360) and MGF505 genes (ASFV-G-D

123 Multigene family 360 (MGF360) and MGF505 represent a gro

124 sine, (2) determination of when members of a multigene family acquire distinct activities, (3) applic

125 shock protein 70s (Hsp70s) are encoded by a multigene family and are located in different cellular c

126 hown that subfamily 1 receptors encoded by a multigene family are present in all charophytes examined

127 Phylogenetic analysis revealed multigene family associations and faster evolution of ea

128 Like PRF and SPF, PMF is produced by a multigene family characterized by gene duplication and h

129 ity-related factor prediction, orthology and multigene family classification, transcriptome analyses,

130 Phylogenetic analyses assigned the vap multigene family complement from pVAPN, pVAPA, and pVAPB

131 RIFIN proteins are products of a polymorphic multigene family comprising approximately 150-200 genes

132 rabidopsis thaliana, AUX1 belongs to a small multigene family comprising four highly conserved genes

133 TbPT0 belongs to a clustered multigene family consisting of five members, whose expre

134 In angiosperms, CAD is encoded by a multigene family consisting of members thought to have d

135 erefore, the Sperm dynein intermediate chain multigene family contributes to the differential reprodu

136 hicken Ig-like receptors (CHIRs) represent a multigene family encoded by the leukocyte receptor compl

137 In Arabidopsis, a multigene family encodes six SUS (SUS1-6) isoforms.

138 A heretofore-unrecognized multigene family encoding diverse immunoglobulin (Ig) do

139 analysis of the Chlamydiaceae has revealed a multigene family encoding large, putatively autotranspor

140 Certain genes in the Jonah multigene family encoding serine proteases have been imp

141 e recruitment is a common phenomenon in tRNA multigene family evolution and should be taken into cons

142 The birth-and-death model of multigene family evolution describes patterns of gene or

143 rsed repeat (pir) genes comprise the largest multigene family in many Plasmodium spp.

144 ent of microtubules, alpha-tubulin is also a multigene family in many species.

145 s related-10 (PR-10) proteins are present as multigene family in most of the higher plants.

146 g our understanding of the evolution of this multigene family in nonmodel avian groups.

147 remarkable Laverania-specific expansion of a multigene family involved in erythrocyte remodelling, an

148 The MASP multigene family is specific to T. cruzi, accounting for

149 known as PfEMP1 and encoded by the multicopy multigene family known as the var genes.

150 er protection in a mouse model and to be the multigene family member primarily expressed in mammalian

151 Rhodococcus sp. NS1 and harbors six new vap multigene family members (vapN to vapS) in a vap pathoge

152 To date, certain members of this multigene family occur only in mycobacteria that cause d

153 ences patterned after conserved regions in a multigene family of 56 subtilisin-related proteolytic en

154 Proteins expressed from the map1 multigene family of Ehrlichia ruminantium are strongly r

155 rabidopsis thaliana) aldehyde oxidases are a multigene family of four oxidases (AAO1-AAO4) that oxidi

156 E. chaffeensis has a multigene family of major outer membrane proteins with p

157 different protein cargoes including the MASP multigene family of proteins MASPs are specific to this

158 Glutathione transferases are a multigene family of proteins that catalyze the conjugati

159 rgonaute (AGO) proteins are a well-conserved multigene family of regulators mediating gene silencing

160 Connexins comprise a multigene family of transmembrane proteins that form gap

161 nition may be mediated by a complex germline multigene family of V structures resembling those that a

162 A multigene family produces tubulin isotypes that are expr

163 Our work suggests that the wtf multigene family proliferated due to meiotic drive and h

164 Claudin-8 (CLDN8), a multigene family protein that constitutes the backbone o

165 of these chromosomally proximal members of a multigene family provides a mechanism for both immune ev

166 squito D7 salivary proteins are encoded by a multigene family related to the arthropod odorant-bindin

167 We deleted all the members of this multigene family resident on the X chromosome of D. mela

168 te immune type receptors (LITRs) represent a multigene family that encodes Ig superfamily proteins th

169 erged in primitive land plants and founded a multigene family that is conserved in all flowering plan

170 er, we report for the first time a bacterial multigene family that undergoes birth-and-death evolutio

171 InlF, a member of the internalin multigene family with no known function, was identified

172 ycopersicum), cryptochromes are encoded by a multigene family, comprising CRY1a, CRY1b, CRY2, and CRY

173 protein expression from many members of the multigene family, despite primary high-level expression

174 ors (ORs), encoded by the largest vertebrate multigene family, enable the detection of thousands of u

175 birth-and-death evolution within a bacterial multigene family, our results indicate that the extent o

176 However, Naip5 is a member of a small multigene family, raising the possibility of redundancy

177 Ets1 is a member of a multigene family, several members of which are expressed

178 One such multigene family, the acyl-CoA desaturases, is composed

179 The Sperm dynein intermediate chain multigene family, which encodes a Sperm dynein intermedi

180 These studies show that multigene family-specific antibodies can be applied to t

181 to reflect functional specification of this multigene family.

182 It is highly conserved and encoded by a multigene family.

183 mylase (BAM) activity, which is encoded by a multigene family.

184 luding Arabidopsis and rice, contains a CAF1 multigene family.

185 f the surface-associated interspersed (surf) multigene family.

186 use of the difficulty in deleting this large multigene family.

187 rved in the Diptera and may be a member of a multigene family.

188 specifically altering a single gene within a multigene family.

189 the prototypic member of a novel B7-related multigene family.

190 usly, we identified the conserved obstructor multigene-family, which encodes chitin-binding proteins.

191 his review describes the state of the art in multigene genetic engineering of plants.

192 nce of germline variants in other genes from multigene hereditary cancer testing panels is not well d

193 lly expressed gene), (2) periostin, or (3) a multigene IL-13 in vitro signature (IVS).

194 B and T lymphocyte systems and a polymorphic multigene immune complex, but little is known about the

195 ucted haplotypes at both individual-gene and multigene levels.

196 teropsis semialata, a species that possesses multigene LGT fragments that were acquired recently from

197 ation-level RAD sequencing, we show that the multigene LGT fragments were rapidly integrated in the r

198 istone-modifying enzymes coexist on the same multigene locus and play a crucial role in the precise c

199 e of mammals, particularly in that the large multigene locus seen in mammals is absent.

200 tightly controlled expression from a complex multigene locus.

201 ase-like protein gene, W1-COE, within the W1 multigene locus.

202 Several multigene markers that predict relapse more accurately t

203 gramming cellular phenotypes and controlling multigene metabolic pathway expression.

204 tion data sets identified and confirmed four multigene models (BI, ICE, BICE, and BITE, with each let

205 ng in fibroblast cells including single- and multigene modifications, chromosome rearrangements, and

206 s Analysis Phylogenetics), to assemble these multigene/multi species matrices and to evaluate the sig

207 In cohort 1, MT for a multigene mutation panel was performed for nonbenign cyt

208 These results help us understand the multigene nature of actinoporins and may be extended to

209 scle samples to elucidate the involvement of multigene neighborhoods in the regulation of MRF genes.

210 With the increasing use of multigene next-generation sequencing panels in hereditar

211 ff for mutational load can be identified via multigene NGS tumor profiling, which provides a highly a

212 on of both coding and noncoding RNAs, act on multigene operons and can be predictably tethered into h

213 lements, and riboregulators into single- and multigene operons with predictable functions in bacteria

214 ables reliable and predictable regulation of multigene operons.

215 cycling occurs, including microRNA loci and multigene operons.

216 tions, genetic counseling and testing with a multigene panel could be considered for all patients wit

217 s, next-generation sequence analysis using a multigene panel detected actionable germline variants in

218 targeted mutation test, single-gene test, or multigene panel for Noonan syndrome, or (2) untargeted g

219 ophic cardiomyopathy genetic testing (either multigene panel or familial variant test) were recruited

220 Subsequently, multigene panel testing (105 or 177 IRD-associated genes

221 implications of somatic mutation profiling, multigene panel testing for cancer susceptibility, quali

222 In a clinically representative cohort, multigene panel testing for HBOC risk assessment yielded

223 Multigene panel testing identified 114 probands with Lyn

224 n individuals with suspected Lynch syndrome, multigene panel testing identified high-penetrance mutat

225 We carried out multigene panel testing on all participants, then determ

226 Multigene panel testing pointed to a molecular diagnosis

227 (MMR) mutation carriers ascertained through multigene panel testing, evaluate their phenotype, and c

228 iewed clinical histories of patients who had multigene panel testing, including the MMR and EPCAM gen

229 those with normal MSI/IHC, should be offered multigene panel testing.

230 All participants underwent germline multigene panel testing.

231 Multigene panel tests have identified increasing numbers

232 P53, and 1 in CHEK2), all identified through multigene panel tests.

233 a research-based next-generation sequencing multigene panel.

234 Multigene panels are commercially available tools for he

235 emental value compared with disease-specific multigene panels that have been the cornerstone of genet

236 evolving owing to the recent introduction of multigene panels.

237 predisposition genes with hereditary cancer multigene panels.

238 ly incorporated into the control of complex, multigene pathways and cellular functions.

239 Recombination," a robust method for building multigene pathways directly in the yeast chromosome.

240 adly accessible methodology for constructing multigene pathways inside of the cell.

241 ake possible large-scale projects focused on multigene pathways or genome-wide alterations.

242 We demonstrate that insulated multigene PB transposons can stably integrate and faithf

243 Based on these features and results of a multigene phylogenetic analysis, a new genus and species

244 olutionary position is robustly supported by multigene phylogenetic analysis.

245 We therefore provide the first multigene phylogenetic evidence that Coleochaetales repr

246 cient to place the cell within the ToL using multigene phylogenetics and provided preliminary insight

247 cogency of such processes is limited without multigene phylogenies.

248 We also constructed a fossil-calibrated, multigene phylogeny to study the evolutionary history an

249 We reconstruct a multigene phylogeny to trace the evolution of colonialit

250 A multigene predictor for distant recurrence-free survival

251 94) and PR expression (ICC = 0.90), and in a multigene predictor of ER pathway activation (ICC = 0.98

252 apeutic targets, and support the use of this multigene predictor to improve risk stratification for i

253 t control were all highly represented in the multigene predictor.

254 ancer, and discuss prognostic and predictive multigene predictors.

255 ions had the worst outcomes, suggesting that multigene profiling may be useful for therapeutic planni

256 Here, we report a massively parallel, multigene-profiling nanoplatform to compartmentalize and

257 Several multigene protease families have been implicated in canc

258 SEEK provides multigene query searching with iterative metadata-based

259 Here, we introduce 'TEMTAC', a multigene recombineering and delivery system for simulta

260 xible regulators that modulate expression of multigene regulons to allow cells to adapt to an array o

261 Using multigene reporter and fate-reporter systems, we demonst

262 RhsA is a member of the multigene Rhs family and consists of a complex genetic s

263 A multigene risk scoring model based on 7 landscape genes

264 n of a set of dissimilar genes in a repeated multigene segment.

265 ovide insights into copy number variation of multigene segments, using as the example a disease resis

266 was evaluated by comparison with results of multigene sequence-based typing, whereas performance in

267 We obtained 402 new multigene sequences from the 12S rRNA, 16S rRNA, and tRN

268 Multigene sequencing identified the spirochaete as a nov

269 al-time polymerase chain reaction (PCR), and multigene sequencing.

270 e aimed to develop and validate a prognostic multigene signature to improve prediction of recurrence

271 A multigene signature, previously reported as predictive f

272 Substantial agreement was also observed for multigene signatures of cancer recurrence (ICC = 0.71) a

273 ate the construction of increasingly complex multigene structures at the DNA level while enabling the

274 l topology using protein concatenation and a multigene supertree method based on 3,242 single gene tr

275 in variable systemic performance in designed multigene systems.

276 ped a next-generation sequencing (NGS)-based multigene-targeted panel for SCID and other severe PIDDs

277 e genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, tes

278 valuation framework for inherited PCA in the multigene testing era.

279 Multigene testing in this setting is likely to alter nea

280 Multigene testing panels now exist for many cardiovascul

281 Critical needs include optimized multigene testing strategies that incorporate evolving g

282 ncer who had not undergone either single- or multigene testing.

283 samples, including 2 commercially available multigene tests (MGTs).

284 Anchoring the coding region rbcL in multigene tiered approach, the combination rbcL + matK +

285 syndrome is a hypertensive, multifactorial, multigene trait affecting meat-type chickens imposing si

286 r obstacle when planning the introduction of multigene traits into transgenic plants.

287 Progress in breeding to improve complex multigene traits, such as drought stress tolerance, has

288 ffold RNAs can be used to generate synthetic multigene transcriptional programs in which some genes a

289 Multigene transcriptional signatures from infected lungs

290 sistance genes that can be incorporated into multigene transgenic cassettes to control this devastati

291 ere created by the coordinate induction of a multigene transport system, involving solute carriers (e

292 RecWay assembly of multigene transposon vectors allows for widely applicabl

293 a novel approach for conducting multisample, multigene, ultradeep bisulfite sequencing analysis of DN

294 with the family pedigree, confirms existing multigene variants and suggests new copy number variants

295 ows for the generation of randomly assembled multigene vector libraries.

296 vectors and adapt our vectors for cloning on multigene vector systems in various binary plasmids.

297 These multigene vectors are integratable, and later excisable,

298 improved the expression of stably integrated multigene vectors by incorporation of insulator elements

299 By the introduction of multigene vectors carrying the human sialylation pathway

300 s to prevent promoter interference seen with multigene vectors.