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1 to cause the defect, indicating that AVSD is multigenic.
2 ice indicated that the percent mortality was multigenic.
3  (HRR) is not fully understood but is likely multigenic.
4 dicated that whitefly resistance to MEAM1 is multigenic.
5  is not fully understood and is likely to be multigenic.
6 f genes across the genome, allowing complex, multigenic adaptations to evolve.
7 vian influenza viruses (AIVs) are considered multigenic, although the best characterized virulence fa
8 is is the first comprehensive study to use a multigenic analysis for bladder cancer, and the data sug
9                                 This type of multigenic analysis in human tumors may serve to substan
10           Asexual transmission appears to be multigenic and although the specific genes mediating thi
11             The effects of Zfp335(bloto) are multigenic and cannot be attributed to altered thymic se
12                                          The multigenic and complex etiology of ARD in humans is refl
13 , such as identifying the molecular basis of multigenic and complex traits.
14 g1-mediated resistance response appear to be multigenic and complex, as judged by transcript abundanc
15 gest that OA severity and progression have a multigenic and feature-specific nature.
16 left heart syndrome (HLHS), a severe CHD, is multigenic and genetically heterogeneous.
17                 Here we show that the QTL is multigenic and includes alternative alleles of srx-44, a
18 xenotic resistance traits providing a potent multigenic and multi-faceted resistance to whiteflies wi
19 pproximately 1 log (P = 0.017), and both the multigenic and Tat/Env groups reduced chronic viremia by
20  the hypothesis that the virulence of NDV is multigenic and that the cleavability of F protein alone
21  in man is a challenge as the cause is often multigenic and the phenotype is modulated by environment
22 E clinical phenotype is genetically complex, multigenic, and heterogeneous.
23 ty of avian influenza viruses in mammals are multigenic, and overcoming them requires adaptations in
24 -moderate hypertriglyceridaemia is typically multigenic, and results from the cumulative burden of co
25                   These data demonstrate how multigenic animal models that reference cancer genomes c
26  629 unaffected white controls, we applied a multigenic approach to examine the associations with bla
27 udy, we demonstrate that within the complex, multigenic architecture of tuberculosis susceptibility,
28                                     Lupus, a multigenic autoimmune condition in which a breakdown of
29                     Fanconi anemia (FA) is a multigenic autosomal recessive cancer susceptibility syn
30  the strain distribution pattern suggested a multigenic basis of disease resistance.
31 blished vl as a mouse model for studying the multigenic basis of NTDs and cataracts.
32 ained elusive and most models have posited a multigenic basis of resistance.
33 evidenced by its heterogenous manifestation, multigenic basis, and sporadic occurrence.
34 scriptional epistasis is a central aspect of multigenic breast cancer progression and outlines method
35 ry sensory neuron (OSN) populations, through multigenic changes.
36 s, and gene repression in lamina-interacting multigenic chromatin domains were analyzed in Drosophila
37 se gene cluster of spinach chloroplasts is a multigenic cluster that encodes the small ribosomal subu
38  but no large effects were observed for long multigenic CNVs (as seen in schizophrenia and autism).
39 tly decreased from small oligogenic to large multigenic CNVs (r = -0.88, p = 8.78 x 10(-6)).
40          It is also unknown if the effect of multigenic CNVs are driven by a few genes intolerant to
41 ity: oligogenic copy number variants (CNVs), multigenic CNVs, and polygenic risk scores (PRSs) as wel
42 uman cancer, often as emergent properties of multigenic combinations.
43                          The large (220 kbp) multigenic complex R-r is paramutable: its level of expr
44 nce a phenotype; and several examples of how multigenic conditions, both complex disorders and duplic
45             Hirschsprung disease (HSCR) is a multigenic, congenital disorder that affects 1 in 5,000
46  rationale for larger studies to investigate multigenic contributions.
47  quantitative traits and contribute to their multigenic control in a semidominant fashion.
48 genetic interactions suggest a model for the multigenic control of anterior digit patterning during v
49  epistatic analyses, seeking to decipher the multigenic control of circadian pacemaking.
50 rentiating maize and teosinte are each under multigenic control, although for some traits, such as th
51  inbred strains, and susceptibility is under multigenic control.
52 tumor induction in mice by pristane is under multigenic control.
53 enetic etiologies, including single-gene and multigenic copy number variants (CNVs).
54 ons contribute to the pathogenicity of rare, multigenic copy-number variants (CNVs) that have been ob
55 itating population genetic analysis of large multigenic datasets.
56 as helped identify a rich array of mono- and multigenic defects in humans and animal models that conn
57 ed to LDL size, supporting the hypothesis of multigenic determination of LDL size heterogeneity.
58         The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific l
59          We propose that PNTM infection is a multigenic disease in which combinations of variants acr
60         Our results indicate that cord1 is a multigenic disease in which mutations in neither RPGRIP1
61                     Fanconi anemia (FA) is a multigenic disease of bone marrow failure and cancer sus
62  Prevailing paradigm suggests that HLHS is a multigenic disease of co-occurring phenotypes.
63                                  Cancer is a multigenic disease resulting from both germline suscepti
64 ET mutations and disease severity even for a multigenic disease such as Hirschsprung disease.
65 l anemia is not a monogenic disease; it is a multigenic disease.
66 ages of polypharmacology in the treatment of multigenic diseases and infections, and opportunities fo
67 e same deleterious variants, and for common, multigenic diseases using as few as 150 cases.
68 apy and in identifying genes responsible for multigenic diseases.
69  of the IGEs that are inherited are complex, multigenic diseases.
70 elated macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision
71                      Cancer is a progressive multigenic disorder characterized by defined changes in
72                            Hypertension is a multigenic disorder in which abnormal counterregulation
73 hy, and that myotonic dystrophy represents a multigenic disorder.
74 ology can identify important disease hubs in multigenic disorders, and reveal mechanisms relevant to
75                                     For most multigenic disorders, clinical manifestation (penetrance
76 ironment interactions that influence complex multigenic disorders.
77  in disease pathogenesis for common, complex multigenic disorders.
78 me-wide scans that exploit LD to map common, multigenic disorders.
79 ase models may impact the treatment of human multigenic disorders.
80                                           In multigenic DNA domains, we observe either bursty transcr
81 simplify the preparation and manipulation of multigenic DNA polymorphism datasets.
82 ed in decreased compactness of the repressed multigenic domain associated with its detachment from th
83 omatin compaction, and gene silencing in the multigenic domain, and an auxiliary role for HDAC3 that
84 sessing every possible combination of 69,123 multigenic editing strategies for 21 lignin biosynthesis
85 l ancestries, and a disentangled complex HLA multigenic effect.
86       More common forms may also result from multigenic effects or post-zygotic mutations.
87 Mutations from seven HLHS mouse lines showed multigenic enrichment in ten human chromosome regions li
88         Furthermore, these results support a multigenic etiology for prostate cancer.
89 SGs conserved across vertebrates, as well as multigenic families diversified independently in each ta
90                                        Thus, multigenic families encoding diversified V regions exist
91          Plasmodium falciparum possesses two multigenic families, var and rif, the products of which
92                                    The large multigenic family of nuclear encoded chloroplastic prote
93 onstrate that Bc28.1, a major member of this multigenic family, is expressed at high levels at the su
94                      Two such are the use of multigenic feedback loops to ensure the progressivity of
95 s against Gag induced in mice immunized with multigenic gagpol plasmids were similar to those observe
96         The differential expression of these multigenic genes provides a rare glimpse into cell wall
97 r reduction in the Tat/Env group than in the multigenic group (P = 0.014) was correlated with Tat and
98                                 However, the multigenic group blunted acute viremia by approximately
99 enhance chronic viremia control, we tested a multigenic group: Ad-HIV tat, -HIV env, -SIV gag, and -S
100 duced pathology is affected by a complex and multigenic host component.
101 iple homozygous genes (for example, to model multigenic human diseases).
102  of individual gene loci to investigation of multigenic human traits, and it establishes an approach
103 chizophrenia risk in 22q11.2DS, supporting a multigenic hypothesis for schizophrenia.
104 ese diseases has led to their designation as multigenic--implying that the expression levels and alle
105 of these resources by lipolysis is similarly multigenic in determination and regulation.
106                                              Multigenic influences are major contributors to human ge
107 or haploinsufficiency, with implications for multigenic inheritance of CHDs.
108  the pedicellate spikelet, the data indicate multigenic inheritance with no single locus having a dra
109             A new study focuses attention on multigenic interactions influencing the risk of autism s
110 lts support the concept of an AP-1-regulated multigenic invasion program in which proteins encoded by
111 rate that the EILV host range restriction is multigenic, involving at least one gene from both nonstr
112 ve trait loci have been mapped in mice, but "multigenic" is an insufficient term for the thousands of
113     Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cance
114  understanding how so many variants of these multigenic loci could have evolved through duplication a
115 lationships between individual components of multigenic loci in regulating cancer progression.See rel
116 , they enable the analysis of large genes or multigenic loci in vivo.
117 esize that the individual components of such multigenic loci may play cooperative or competing roles
118  perspectives to the functional landscape of multigenic loci.
119                                            A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is
120 restricted transcriptional regulation from a multigenic locus.
121 stage-specific expression of genes from this multigenic locus.
122  Mphi from the two principal mouse models of multigenic lupus provides insight into how excessive hum
123 lation in the two principal animal models of multigenic lupus, and suggest that the study of Mphi (an
124  congenital amaurosis through a recessive or multigenic mechanism.
125 n this discovery candidate gene set suggests multigenic mechanisms underlie sub-phenotype-specific ca
126 f "complex traits" can be understood using a multigenic model of candidate genes.
127 vide a potential mechanistic basis for a new multigenic model of HPE.
128                                            A multigenic model of prostate cancer susceptibility has b
129 re, Tcf4 haplodeficiency in the B6.Sle1.Sle3 multigenic model of SLE nearly abolished key disease man
130           Here we tested the ability of this multigenic model to predict stroke risk in a large popul
131                                              Multigenic models based on this trait predicted the risk
132        Here we use Drosophila to generate 32 multigenic models of colon cancer using patient data fro
133                                              Multigenic models such as ras p53 pten apc exhibit emerg
134 inflammatory molecules may be used to create multigenic models that predict stroke risk in subjects w
135                         Our work exposes the multigenic, molecular etiology of a variant associated w
136 ctional dissection of susceptibility loci in multigenic mouse models of lupus has provided insight in
137 d PRKDC) immunodeficient rabbits, as well as multigenic mutant immunodeficient rabbits have been prod
138                      Unexpectedly, given the multigenic nature and partial functional redundancy obse
139                                   The highly multigenic nature of dosage-sensitive modulation of both
140                                 The complex, multigenic nature of HLA class II-associated IDDM suscep
141 these AIDS restriction genes illustrates the multigenic nature of host factors limiting AIDS disease
142                                          The multigenic nature of human tumours presents a fundamenta
143 present known limitations given the complex, multigenic nature of many diseases or traits.
144  extent of natural genetic variation, 2) the multigenic nature of natural variation, 3) the impact of
145                  The results demonstrate the multigenic nature of susceptibility to urinary tract inf
146 ssociated with resistance, demonstrating the multigenic nature of this phenotype.
147 ties has been challenging due in part to its multigenic nature.
148 irschsprung disease (HSCR, MIM #142623) is a multigenic neurocristopathy (neural crest disorder) char
149             Hirschsprung disease (HSCR) is a multigenic neurocristopathy clinically recognized by aga
150                Alzheimer's disease (AD) is a multigenic neurodegenerative disorder characterized by d
151  immunodeficiency virus (SIV) Gag and Pol as multigenic, nonintegrating vectors, but rBCG-expressing
152 eral candidate genes, including tubby (tub), multigenic obesity 1 (Mob1), adult obesity and diabetes
153 ns with CAST alleles encompassing 67-162 Mb (multigenic obesity 6 [MOB6]) and 84-180 Mb (MOB5) from m
154 the s(1Acrg) phenotype is either complex and multigenic or due to the loss of another gene within the
155 chromosomal interactions results in weak and multigenic OR expression, suggesting that the rare coinc
156 , this investigation provides candidates for multigenic orchestration of the incompatibility response
157 quencing data of a family with a potentially multigenic origin of CHD.
158 ated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these
159 he potential to advance our understanding of multigenic outcomes in plant immunity and can be further
160  4 logs, respectively, compared to controls (multigenic, P = 0.0003; Tat/Env, P < 0.0001).
161                                            A multigenic pathway-based approach may identify gene-gene
162 ur study confirms the importance of taking a multigenic pathway-based approach to risk assessment.
163 ancer, confirming the importance of taking a multigenic pathway-based approach to risk assessment.
164          Several interesting studies using a multigenic pathway-based genotyping approach and novel s
165 itical genes has proven difficult due to the multigenic pattern of inheritance and strong role of cur
166  support the hypothesis that "curlicue" is a multigenic phenomenon.
167 y to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic an
168 e to evolutionary engineering approaches for multigenic phenotypes is the ability to simultaneously m
169 cted to undertake the development of complex multigenic phenotypes, such as aerotolerance, solvent to
170 iation analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be assoc
171  skin disease of unknown cause determined by multigenic predisposition, environmental factors, and ab
172 mary candidate regulating the opening of the multigenic PRM1 --> PRM2 --> TNP2 human protamine domain
173 lection for strains defective in two defined multigenic processes (twitching motility and prototrophi
174 rly, the effects of environmental factors or multigenic processes such as ageing or disease cannot be
175    From these observations we propose that a multigenic program for sensitivity to apoptosis involves
176                                              Multigenic programs controlling susceptibility to apopto
177 breast cancer cells includes alternations of multigenic programs that permit tumor cells to metastasi
178  structures occurs through the activation of multigenic programs.
179            Tick salivary proteins cluster in multigenic protein families, and individual family membe
180 stance and development of type 2 diabetes is multigenic rather than monogenic in origin.
181                     Fanconi anemia (FA) is a multigenic recessive disease resulting in bone marrow fa
182                   Our findings highlight the multigenic regulation of the size of the pDC compartment
183 ong-range chromatin interactions that enable multigenic regulation.
184                                      After a multigenic replicating Ad-SIV immunization, all groups r
185                                         This multigenic resistance avoids rapid evolution of a pathog
186                              Quantitative or multigenic resistance has also more recently been resear
187  with PfCRT and plasmepsins 2/3 in mediating multigenic resistance to antimalarial agents.
188                                              Multigenic resistance to dauer formation has also arisen
189  at high density have independently acquired multigenic resistance to pheromone-induced dauer formati
190 nstrates the need for finding germplasm with multigenic resistance to the aphid.
191  of these platforms to transcripts isoforms, multigenic RNA molecules, and transcriptional overlaps.
192 al machinery can indeed detect and translate multigenic sequences that are not of chloroplast origin.
193 us macaques per group were primed twice with multigenic SIV plasmid DNA with or without interleukin-1
194 cRNA and underscores that LOI phenotypes are multigenic so that complex interactions will contribute
195 rice (Oryza sativa L.), the haplotype at the multigenic SUBMERGENCE1 (SUB1) locus determines whether
196 ic such as Timothy syndrome (TS); others are multigenic such as the microdeletion and microduplicatio
197                          To understand how a multigenic system evolved to adapt to the changing envir
198 es of dormancy genes observed in this simple multigenic system presumably have selective advantages i
199 e design of tailored experiments to identify multigenic targets to address complex diseases.
200 often been described as a complex and likely multigenic trait for which complex gene interactions com
201 for and accurately assessing such a complex, multigenic trait in a natural product such as a fruit.
202 sted that RNA-mediated virus resistance is a multigenic trait in line 2RC-6.13; three or more transge
203         Here we show that patch-leaving is a multigenic trait regulated in part by naturally occurrin
204                  Fasting plasma glucose is a multigenic trait related to both diabetes and obesity.
205                                 Obesity is a multigenic trait that has a substantial genetic componen
206 nation of Medicago truncatula seedlings is a multigenic trait that is responsive to exogenous nitrate
207               Obesity is a highly prevalent, multigenic trait that predicts increased morbidity and m
208                             This is likely a multigenic trait, as replacing the trigNP gene did not d
209 ity gene has been identified for this highly multigenic trait.
210 roid disorder that is inherited as a complex multigenic trait.
211  continuous phenotypic pattern, suggesting a multigenic trait.
212 ene disorder with reduced penetrance or as a multigenic trait.
213 suggested that the NZB apoptosis defect is a multigenic trait.
214     Fetal hemoglobin (HbF) is regulated as a multigenic trait.
215        The virulence of influenza virus is a multigenic trait.
216 traits have a complex genetic basis, but few multigenic traits are understood at a molecular level.
217 ation of oocytes, and teratoma formation are multigenic traits involving a modest number of permissiv
218 dentifying candidate genes encoding QTLs for multigenic traits.
219 ility supports our hypothesis that these are multigenic traits.
220 ough of a single stop codon, but instead are multigenic traits.
221 genome and combinatorially optimize complex (multigenic) traits using multiplex recombineering.
222 riptional responses to auxin rely on a large multigenic transcription factor family, the auxin respon
223 rid selection assays showed that some of the multigenic transcription units of the mitochondrial geno
224 its replication origins to the boundaries of multigenic transcription units.
225 which has demonstrated the ability to elicit multigenic transcriptional changes that have improved ph
226 ut sequencing promise to accelerate our full multigenic understanding of this disease, contributing t
227 important implications in the development of multigenic vaccine candidates for this common infection.
228         We used subtle, naturally occurring, multigenic variation of cardiovascular (CV) properties i
229 analysis of both rare single-gene and common multigenic vascular disorders.
230                                     Finally, multigenic xenografts engineered to prevent complement a

 
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