ライフサイエンスコーパス: multimerization

1 n MACA, indicating the importance of protein multimerization.

2 ions were identified, which impaired protein multimerization.

3 iation that affects HP protein structure and multimerization.

4 HIV-1 Gag to the VCCs requires NC-dependent multimerization.

5 e inhibitor interface blocked ALLINI-induced multimerization.

6 , preference for membrane order, and protein multimerization.

7 contacting acidic lipids or by promoting Gag multimerization.

8 losterically but, rather, by stimulating its multimerization.

9 hich structural determinants underlie native multimerization.

10 ish LPL binding lead to protein dimerization/multimerization.

11 ng of the disintegrin domain, prevents ADAM8 multimerization.

12 micronemia, also led to protein dimerization/multimerization.

13 instead results from oxidation-mediated PML multimerization.

14 MLV Gag via the basic cluster of MA and Gag multimerization.

15 ntially affecting IN levels or functional IN multimerization.

16 argeted glycans, we tested the use of lectin multimerization.

17 s a potential mechanism for GAG-dependent Hh multimerization.

18 oup of membrane proteins is only formed upon multimerization.

19 ion and recruitment domain (CARD) to promote multimerization.

20 y that could be detected only through lectin multimerization.

21 These interactions promote CA domain multimerization.

22 )(6)(0) in the D2 domain as critical for VWF multimerization.

23 s (pK(a) ~6.0) mediates the pH dependence of multimerization.

24 , reverse transcription, integration, and IN multimerization.

25 positively charged NC domains of Gag3 limit multimerization.

26 uctural changes of the TCR allowing improved multimerization.

27 is segment is known to be involved in capsid multimerization.

28 hile the hydrophobic residues function in IN multimerization.

29 on, underlining the functional importance of multimerization.

30 important for KF116 mediated higher-order IN multimerization.

31 ma1R ligands had distinct effects on sigma1R multimerization.

32 ytoskeleton is required for zinc-induced cis multimerization.

33 sis, we examined the domains involved in HuR multimerization.

34 tion at Asn-563 is essential for controlling multimerization.

35 HuR domains involved in cancer cell-specific multimerization.

36 olecular factors influencing alpha-synuclein multimerization.

37 zipper dimerization motif that promotes Gag multimerization.

38 are remarkably resistant to the drug-induced multimerization.

39 ropriate receptor self-association and/or HA multimerization.

40 , and these substitutions also diminished IN multimerization.

41 tention or degradation of VWF, (2) defective multimerization, (3) loss of regulated storage, and (4)

42 e and strongly impair nucleotide binding and multimerization ability.

43 Localization of multimerization activity to the C terminus led to the di

44 rting this, alpha-syn mutations that disrupt multimerization also fail to restrict synaptic vesicle m

45 However, CARD-mediated multimerization also makes Aire susceptible to interacti

46 Reduced activity of AtxA H199A, lack of multimerization and activity of AtxAH379D variants, and

47 palmitoylation of HCMV gB and its role in gB multimerization and activity.

48 se susceptibility, release by osmotic shock, multimerization and affinity for metal cofactors.

49 For biological function, ADAM8 requires multimerization and associates with beta1 integrin on th

50 protein was shown to be involved in protein multimerization and binding to single and double strande

51 extensions that have been linked to protein multimerization and cellular localization.

52 As multimerization and clustering is a prerequisite for TNF

53 RNA; (ii) adversely affecting functional IN multimerization and consequently impairing IN binding to

54 inct Cys-->Ser substitutions were tested for multimerization and cross-linking.

55 t; removal of this linker impairs both Cox15 multimerization and enzymatic activity.

56 ole of allosteric IN inhibitors in promoting multimerization and explained why several C-terminal dom

57 d that the central domain regulates Poltheta multimerization and governs its DNA substrate requiremen

58 These results indicate that the multimerization and IN binding properties of INI1 are ne

59 Although ALLINIs promote aberrant IN multimerization and inhibit IN interaction with its cell

60 sm of action by allosterically modulating IN multimerization and interfering with IN-lens epithelium-

61 GP(Y/F) residues may play roles in promoting multimerization and intermolecular strand joining.

62 actively participates in the process of VWF multimerization and is essential for trafficking of VWF

63 significant correlation between adiponectin multimerization and its insulin-sensitizing effects has

64 omain and hydrophobic groove did not inhibit multimerization and mitochondrial damage, indicating tha

65 We propose that Rev multimerization and NES masking regulates Rev's traffick

66 on of storage granules, and was defective in multimerization and platelet binding.

67 oundation for therapies that target ZikV-NS5 multimerization and prevent the developmental malformati

68 -abolishing alphaS variant but also restored multimerization and prevented the aberrant vesicle inter

69 ing and beta-structure formation inhibits FN multimerization and prevents physiological cell-based FN

70 ptide (VWFpp) and mature VWF aids N-terminal multimerization and protein compartmentalization in stor

71 ut are instead due in part to differences in multimerization and receptor-ligand stoichiometry confer

72 t a high degree of plasticity for functional multimerization and reveal a critical role of the C-term

73 its robust inhibition of virus-induced RIG-I multimerization and RIG-I-MAVS signaling complex formati

74 NC is also critical for Gag multimerization and RNA binding.

75 nteractive protein that promotes adiponectin multimerization and stability in obesity-induced endopla

76 hanisms by which obesity impairs adiponectin multimerization and stability, and 2) to determine the p

77 ctured motifs in LINP1 bind Ku, promoting Ku multimerization and stabilization of the initial synapti

78 nd D3 domains that are known to regulate VWF multimerization and storage.

79 naptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uni

80 on to the previously demonstrated N-terminal multimerization and the first two PDZ (PSD-95, Dlg1, zon

81 emia subtype M4Eo, contains domains for self-multimerization and transcriptional repression, both of

82 FLEXamers unite reversible multimerization and versatile probe conjugation through

83 The compounds promote virion IN multimerization and, reminiscent of class II IN mutation

84 ion regulates TGFbeta receptor organization, multimerization, and function, providing new insight int

85 unavailable owing to its large size, complex multimerization, and functional differences of the multi

86 idues important for inducer binding, protein multimerization, and interaction with RNA polymerase at

87 tive rates of translational repression, mRNP multimerization, and mRNA decay.

88 to its function, the extent of VWF release, multimerization, and polarity of the 3 secretory pathway

89 n genesis, coincident with membrane binding, multimerization, and proteolytic maturation.

90 on downstream of residue 136 is required for multimerization, and the region downstream of residue 20

91 g DNA, PRDM9's zinc fingers also mediate its multimerization, and we show that a pair of highly diver

92 that domains within Gag known to mediate Gag multimerization are also required.

93 Although IN binding and multimerization are required for INI1-mediated inhibitio

94 ations that are predicted to impair receptor multimerization are rescued by overexpression of TSPAN12

95 s provide structural clues for exploiting IN multimerization as a new, attractive therapeutic target

96 ts into the physiological relevance of GLUT1 multimerization as well as a new variant of BRET assay t

97 g (as revealed by mobility shift assays) and multimerization (as revealed by gel filtration, dynamic

98 zed the defect in DDX6-depleted cells to Gag multimerization at the plasma membrane.

99 maturation by inducing hyper- or aberrant IN multimerization but are largely ineffective during the e

100 Upon netrin-1 stimulation TRIM9 promotes DCC multimerization, but TRIM9-dependent ubiquitination of D

101 ith avian-type receptor specificity required multimerization by antibodies before binding to glycans

102 V-1 integrase inhibitors promote aberrant IN multimerization by bridging IN-IN intermolecular interac

103 a1)-activated human myofibroblasts underwent multimerization by o,o'-dityrosine cross-linking under r

104 Disruption of HDAg multimerization by site-directed mutagenesis was found t

105 Here, we explore the early steps in the IN multimerization by using umbrella sampling and unbiased

106 sing single-molecule analysis, and show that multimerization can be blocked by mutations in a specifi

107 ma membrane for viral assembly, and that Gag multimerization can further enrich PIP2 at assembly site

108 opisthorchiasis and CagA and CagA with CagA multimerization (CM) sequence-positive H. pylori.

109 of FP11-tag as a labelling tool as well as a multimerization-control tool for both imaging and non-im

110 a suggest that NS5A-NS5A dimerization and/or multimerization could represent a novel target for the d

111 molecular weight IN-INI1 complexes, and the multimerization-defective mutant was unable to form thes

112 Multimerization-defective mutants are also defective for

113 ity to tolerate a SNES was both position and multimerization dependent, an observation consistent wit

114 rear-end protrusion known as the uropod in a multimerization-dependent manner.

115 membrane binding and targeting and suggest a multimerization-dependent mechanism for Gag trafficking

116 In many complexes, however, multimerization does not enable any known function(3).

117 N function in vivo as overexpression of this multimerization domain caused increased sensitivity to c

118 The role of an N-terminal multimerization domain in the supramolecular organizatio

119 the yeast two-hybrid system to determine the multimerization domain of ELAV.

120 the ALL-associated PAX5 fused to ETV6 or the multimerization domain of ETV6 SAM results in stable chr

121 We present the crystal structure of the multimerization domain of Nipah virus P: a long, paralle

122 indings further suggest that the less stable multimerization domain provides a potential target for m

123 Notably, the introduction of a heterologous multimerization domain restored PI(4,5)P2-dependent PM-s

124 ain is more resistant to disruption than the multimerization domain suggesting the twisted structure

125 ests this Nab3 'tail' forms an alpha-helical multimerization domain that helps assemble it onto an RN

126 at the Rpt1 and Rpt2 motifs form the minimal multimerization domain.

127 ckaging via interactions with the N-terminal multimerization domain.

128 ieved 13 mutations affecting both I2 and the multimerization domains of IntI1.

129 nt interactions between the dimerization and multimerization domains that were most active at acidic

130 Silencing of immunogenic multimerization domains with glycans might be relevant f

131 itial steps including proprotein processing, multimerization driven by the C terminus, and the head-t

132 mechanism of action by inducing aberrant IN multimerization during virion morphogenesis and by compe

133 Mutant HDAg proteins defective for multimerization exhibited neither the 300-nt RNA size re

134 4-ORF3 mutant, which is defective in protein multimerization, exhibited severely decreased activity,

135 the predicted dimensions on the DNA, with CI multimerization favoured by DNA binding.

136 t of retroviral gag capsid domains and whose multimerization has been proposed as a model for retrovi

137 overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereby regulating system

138 localization of PopZ largely relies on PopZ multimerization in chromosome-free regions, consistent w

139 analysis of this tumor-specific HuR protein multimerization in clinical brain tumor samples.

140 , our findings provide new insights into HuR multimerization in glioma and highlight possible pharmac

141 hree) HuR molecules come together during HuR multimerization in glioma cells.

142 sing these data, we developed a model of HuR multimerization in glioma cells.

143 We conclude that extensive multimerization in large ficolin-3 multimers leads to a

144 To directly address the role of multimerization in membrane binding, we fused the MA dom

145 through conjugation of probes or reversible multimerization in separate production processes, which

146 To assess a role for multimerization in silencing, we conducted structure mod

147 rization of pp28 within the AC and that pp28 multimerization in the AC represented an essential step

148 , we investigated the potential role of pp28 multimerization in the envelopment of the infectious vir

149 study specifically examines the role of HDAg multimerization in the formation of the HDV ribonucleopr

150 reases the stability of KaiA in vivo, causes multimerization in vitro, and blocks KaiA stimulation of

151 Monitoring alpha-synuclein multimerization in vivo.

152 Here, we report HuR aggregation (multimerization) in glioma and the analysis of this tumo

153 ne, Gag association with lipid rafts, or Gag multimerization, indicating that the mechanism of inhibi

154 tosolic dopamine caused an increase in DISC1 multimerization, insolubility and complexing with the do

155 kage between the oxygen binding site and the multimerization interface was already an intrinsic featu

156 in forming multiple electrostatically driven multimerization interfaces.

157 her constraints of interaction or additional multimerization interfaces.

158 spindlin at the spindle midzone requires its multimerization into clusters and Aurora B kinase activi

159 A mechanism of multimerization into higher-order asymmetric oligomers v

160 e in the oligomerization of MtsR on DNA, and multimerization is critical for MtsR regulatory activity

161 our results further underpin the model that multimerization is critical for PM association of retrov

162 Multimerization is enhanced in the presence of heparin a

163 rotein and suggest that higher-order protein multimerization is essential for E4-ORF3 activity.

164 This multimerization is evolutionarily conserved and independ

165 We conclude that Cox15 multimerization is important for heme a biosynthesis and

166 j3's substrate binding ability, arguing that multimerization is important for substrate binding.

167 ion with Fab1 or Fig4, suggesting that Vac14 multimerization is likely the first molecular event in t

168 CD1/CD2 domains connect and how dimerization/multimerization is linked to RNA binding and virion pack

169 ns and support a model in which SAM-mediated multimerization is necessary for TIR-dependent engagemen

170 se interactions promote higher-order protein multimerization is not clear.

171 Dimerization/multimerization is relevant to disease pathogenesis, giv

172 Rather, higher-order TRIM69 multimerization is required for its antiviral activity,

173 Cox10 multimerization is triggered by progression of Cox1 from

174 in (DIX) domain, but not DIX domain-mediated multimerization, is essential for DVL's centrosomal loca

175 Impairments in adiponectin multimerization lead to defects in adiponectin secretion

176 We engineered alphaS mutants incapable of multimerization, leading to excess monomers at vesicle m

177 ting that important determinants of helicase multimerization lie outside the helicase domain.

178 This includes actin polymerization, tubulin multimerization, microtubule organizing center formation

179 We explore how substrate multimerization modulates recognition by the ClpX unfold

180 the newly identified compound 5 disrupts HuR multimerization modules and reduces tumor cell survival

181 ion technique, in-source phenomena including multimerization, nonproton cation adduction, and in-sour

182 rly, Sid2 phosphorylation of Cdc12 abrogates multimerization of a previously unrecognized Cdc12 domai

183 Overall, our results imply that multimerization of APOBEC3 proteins may be related to th

184 tes that the Bak apoptotic pore forms by the multimerization of BH3:groove homodimers and reveals tha

185 microscopic imaging to demonstrate that the multimerization of BRCA2 is counteracted by DSS1 and ssD

186 etrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family

187 uncover a function of Pat1 in promoting the multimerization of Dhh1 on mRNA, thereby aiding the asse

188 Potent methylation is dependent on the multimerization of Dnmt3a/Dnmt3L complexes on the DNA.

189 tion, this result suggests that higher-order multimerization of E4-ORF3 may be required for the activ

190 haracterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis,

191 The multimerization of FliG is promoted by FliF and also by

192 SMA-causing missense mutations that block multimerization of full-length SMN are also stabilized i

193 multimers and TSPAN12 cooperatively promote multimerization of FZD4 and its associated proteins to e

194 m, termed OptoGranules, based on optogenetic multimerization of G3BP1, which is an essential scaffold

195 lasma membrane association and capsid-driven multimerization of Gag are sufficient to drive MLV Gag t

196 dent on plasma membrane (PM) association and multimerization of Gag but independent of the viral glyc

197 an approach for probing the galectin-induced multimerization of glycoconjugates on cultured cells.

198 cysteine in the GPIHBP1 Ly6 motif results in multimerization of GPIHBP1, defective LPL binding, and s

199 residues, hydrophobicity at residue 29, and multimerization of HD5, which increases initial binding

200 recombinant proteins show that RelA enhances multimerization of Hfq monomers and stimulates Hfq bindi

201 association responsible for the drug-induced multimerization of HIV-1 integrase (IN).

202 reas the intermolecular interaction leads to multimerization of HTLV-1 NC on the NA.

203 irus viability, strongly suggesting that the multimerization of I3 is biologically significant.

204 We conclude that cooperative multimerization of IN by ALLINIs together with the inabi

205 Instead, ALLINIs markedly altered the multimerization of IN by promoting aberrant higher order

206 intermediates and suggest that differential multimerization of IN in the presence of various ligands

207 infected cells is through inducing aberrant multimerization of IN.

208 pt proper viral maturation by inducing hyper-multimerization of IN.

209 and it remains to be determined whether the multimerization of M1 is affected by its binding to the

210 of MASC target Mto1 to different MTOCs, and multimerization of MASC is important for efficient targe

211 ga4 is still able to bind DNA in vitro, homo-multimerization of Mga is disrupted and the protein is u

212 g a Homo-FRET assay shows that the inducible multimerization of mGBP2 is dependent on a functional GT

213 n yeast gamma-tubulin small complex and that multimerization of Mto2 in particular may underlie assem

214 constitutive dimer of MYO6+, indicating that multimerization of MYO6 on endosomes through binding to

215 Here, we show that multimerization of PAX5 DNA-binding domain (DBD) is nece

216 Interestingly, multimerization of PGLYRP1 bypassed the need for peptido

217 accumulation of pp28 was a prerequisite for multimerization of pp28 within the AC and that pp28 mult

218 - and heteromeric interactions using induced multimerization of protomers within such complexes, at c

219 chain) is a small polypeptide that regulates multimerization of secretory IgM and IgA, the only two m

220 nce of more than one structural conformer or multimerization of some of the molecules.

221 ce the compound reversed the store-dependent multimerization of STIM1.

222 minal phosphorylation sites neither affected multimerization of the channels nor the electrophysiolog

223 active site, as important for the obligatory multimerization of the enzyme and viral replication as a

224 Binding and multimerization of the HIV Rev protein on the RRE promot

225 the LEDGF/p75-binding site promote aberrant multimerization of the integrase enzyme and are of signi

226 avidity-enhanced interactions resulting from multimerization of the ISPs.

227 es promoting stability and another promoting multimerization of the membrane-targeted assembling Gag

228 e for Holliday junctions and does not induce multimerization of the Mus81-Mms4 heterodimer.

229 ovel WRN coiled coil domain is necessary for multimerization of the nuclease domain and sufficient to

230 Multimerization of the peptides results in cell binding

231 rtant role in the inhibitor induced aberrant multimerization of the WT protein.

232 sion of TRPC6, whereas protein stability and multimerization of TRPC6 are not altered, making serine

233 re a major motif in proteins and orchestrate multimerization of various complexes important for biolo

234 clease and helicase domains that facilitates multimerization of WRN.

235 The differential multimerization of WT and A128T INs induced by ALLINIs c

236 itor binding site and which lead to aberrant multimerization of WT but not A128T IN.

237 as the C-terminus is known to stimulate PABP multimerization on poly(A).

238 nt regions by the addition of glycans and/or multimerization on virus-like particles.

239 ults revealed that INI1 residues involved in multimerization overlap with IN-binding and nuclear expo

240 EC3G mutants, which are each compromised for multimerization, packaging and HIV-1 restriction.

241 at nanoparticles (NPs) can be used as ligand-multimerization platforms to activate specific cellular

242 In this study, we found that Gag multimerization prior to budding but beyond dimerization

243 We also found that HIV-1 Gag multimerization promotes PIP2 clustering.

244 ther, our results revealed that NC-dependent multimerization promotes VCC targeting.

245 bers of the APOBEC3 family, we show that the multimerization propensities of APOBEC3B, APOBEC3D, APOB

246 urine GBPs (mGBP1/2/3/5/6), homo- and hetero-multimerization properties of mGBP2 and its function in

247 mo-multimeric protein whose conformation and multimerization properties respond to allosteric activat

248 We provide evidence that multimerization provides a mechanism by which Rev transi

249 Mechanistically, XBP1s promotes adiponectin multimerization rather than activating its transcription

250 We conclude that ALLINIs primarily target IN multimerization rather than IN-LEDGF/p75 binding.

251 ase phosphorylation site proximal to the WRN multimerization region.

252 phaS amphipathic helix formation and dynamic multimerization regulate a normal function of alphaS at

253 assessed secretion/intracellular retention, multimerization, regulated storage, and ADAMTS13 proteol

254 timers, but the mechanism and consequence of multimerization remain incompletely defined.

255 modynamic driving forces and kinetics of the multimerization remain largely unknown.

256 owever, the properties and function of Vac14 multimerization remain mostly uncharacterized.

257 However, the nature of Gag multimerization required for this movement, the composit

258 ring PB1 mutations in Arabidopsis suggests a multimerization requirement for ARF protein repression,

259 cytoplasmic trafficking, oligomerization and multimerization requirements for signaling, and for expa

260 t to begin with Gag dimerization followed by multimerization, resulting in a hexameric lattice.

261 residue substitutions negatively impacted IN multimerization, resulting in an inactive viral enzyme a

262 residue replacement mechanism to block SinR multimerization, resulting in diminished DNA binding and

263 of biological solutions was increased using multimerization, resulting in the detection of lower con

264 The pyridine-based multimerization selective HIV-1 integrase (IN) inhibitor

265 DBD of the transcription factor (TF) and the multimerization sequence of the partner protein can act

266 to the discovery of a minimal 7-amino acid "multimerization sequence" (SLLISWD), which induces polym

267 with the unfolding of 10FNIII to expose the multimerization sequence, which interacts with strand B

268 In addition, WRN nuclease multimerization significantly increased nuclease process

269 te selection mechanisms coupled to different multimerization states.

270 itory and activating responses relies on the multimerization status of IgA and interaction with their

271 Furthermore, APP multimerization stimulated increased protein levels of t

272 tients' phenotype is the result of defective multimerization, storage, and secretion.

273 ion for functional properties that depend on multimerization, such as intersubunit allostery or the c

274 cluding a head and tail domain organization, multimerization that may regulate ligand binding, and pH

275 s two roles: (1) APC promotes efficient Axin multimerization through one known and one novel APC:Axin

276 We propose a structural model for EGFR multimerization through self-association of ligand-bound

277 (318) switch, creating a nucleation site for multimerization through the C-terminal domain for tetram

278 ess (N&B) microscopy to characterize protein multimerization upon interaction with the PM of living c

279 e E345R mutation, which can promote antibody multimerization upon receptor binding, facilitated anti-

280 lated mutants of INI1 that are defective for multimerization using a reverse yeast two-hybrid system.

281 s were also shown to have differences in Rev multimerization using gel shift binding assays.

282 This report demonstrates that antigen multimerization using IMX313 is a simple and effective c

283 These results demonstrate that antigen multimerization using IMX313 is a very promising strateg

284 amino acid residues, mediating front-to-back multimerization via electrostatic interactions.

285 hat the level of binding enhancement through multimerization was not equivalent across patient sample

286 Interestingly, multimerization was not required for binding to tissues.

287 GPIHBP1 dimerization/multimerization was not unique to cysteine mutations; mu

288 entary DNA depressed VWF secretion, although multimerization was only mildly affected.

289 CA multimerization was triggered by multivalent anions prov

290 utation, L30M, potentially affecting insulin multimerization, was identified in five diabetic individ

291 dent of its role in membrane localization or multimerization, we examined the effect of the PBR in th

292 d coils can mediate protein interactions and multimerization, we studied their possible involvement i

293 Reducible fibulin-4 dimerization and multimerization were consistently observed by SDS-PAGE,

294 These in vivo effects of multimerization were reproduced in vitro.

295 proteins or purified Bsp22 showed extensive multimerization which was shown by transmission electron

296 residue cryptic peptide 1 (CP1) initiates FN multimerization, which is mediated by interactions with

297 Thus, multimerization, which is mediated by the N-peptide, is

298 P1s is an important regulator of adiponectin multimerization, which may lead to a new therapeutic app

299 verexpression of DsbA-L promoted adiponectin multimerization while suppressing DsbA-L expression by R

300 APP multimerization with an anti-N-terminal APP antibody, 22