ライフサイエンスコーパス: multimerize

1 Rev function depends on its ability to multimerize.

2 secreted serum protein with the capacity to multimerize.

3 bunit may bind Abeta and the bound Abeta may multimerize.

4 demonstrated that the proteins did not self-multimerize.

5 and outer centromere, obviating the need to multimerize.

6 is a distinct type of BTB domain, which can multimerize.

7 in that it depends on the ability of Gag to multimerize.

8 nd SH3 domains of CIP4 and on its ability to multimerize.

9 ability of the C-terminal domain of TcpT to multimerize.

10 C was a nonmyristoylated Gag protein able to multimerize.

11 ndependently in a dose-dependent manner when multimerized.

12 the optimized immunogen, unless it is highly multimerized.

13 ons in these 10 bp abolished activity of the multimerized 18-bp enhancer, and deletion of these 10 bp

14 By multimerizing a conserved Sxl-Pe sequence block, we gene

15 The multimerized Abs target the cell surface receptors HER2,

16 e for certain AML1 target genes that contain multimerized AML1 consensus sites in their regulatory el

17 ecruitment but essential to allow the AAD to multimerize and activate ATR.

18 Upon ligand binding, Toll appears to multimerize and activate the associated kinase, Pelle.

19 CRACM1 proteins multimerize and bind STIM1, and the combined overexpress

20 Homer 1a does not multimerize and blocks the association of mGluRs with CC

21 These C-terminal fragments are able to multimerize and form amyloid-like fibers.

22 in the early endocytic compartment does not multimerize and is promptly degraded by hepcidin (Hepc),

23 active cdk5 reduces the ability of PSD-95 to multimerize and to cluster neuronal ion channels, two fu

24 nimal segment of Spc105 with a propensity to multimerize and which contains protein binding motifs is

25 ic mice and Syrian golden hamsters that both multimerized and biparatopic Bicycles reduce viraemia an

26 unction as a monocyte-specific enhancer when multimerized and linked to a heterologous basal promoter

27 When multimerized and placed upstream of the native osteocalc

28 nteraction system, we demonstrated that RhlR multimerized and that the degree of multimerization was

29 FANCG are redox-sensitive proteins that are multimerized and/or form a nuclear complex in response t

30 aturation, the inactive proform dimerizes or multimerizes and autocatalytically removes the prodomain

31 Flower multimerizes and is able to form a channel to control Ca

32 R; pyruvate kinase activity reporter), which multimerizes and is activated upon binding FBP.

33 In this study, we demonstrate that N(ICD) multimerizes and that these multimers function as precur

34 he partner protein can act in a DN manner by multimerizing and binding avidly to gene targets, preven

35 o bind viral single-stranded DNA (ssDNA) and multimerize, and for effects on the accumulation of repl

36 sphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase

37 (FRET) to determine whether IL-17RA subunits multimerize, and, if so, whether they are preassembled i

38 fusions may provide a powerful platform for multimerizing antibody and Fab fragments to enhance the

39 re follicular dendritic cells (FDCs) present multimerized antigens as periodically arranged antigen-a

40 activated transcription from reporters with multimerized AP-1 sites.

41 Prior studies have shown that all of these multimerizing APOBEC3 proteins, but not the monomeric fa

42 Using a replacement strategy, we found that multimerized binding sites for the architectural protein

43 Overexpression of ZmWUS1-B is due to multimerized binding sites for type-B RESPONSE REGULATOR

44 Although multimerized binding sites of individual transcription f

45 boundary rescues the bypass defects of these multimerized binding sites.

46 es and activates heterologous promoters from multimerized binding sites.

47 important hubs for molecular biology, either multimerizing biomolecules, bridging one molecule to ano

48 Reporter genes bearing multimerized bulged C lin-4 binding sites show almost wi

49 N-terminal domains of hA3G were unable to multimerize but remained functional for Gag and viral in

50 ns that had the ability to bind C(4)-HSL and multimerize but were unable to activate lasB expression,

51 ELAV/Hu proteins multimerize, but how multimerization contributes to deco

52 All mutants multimerized, but one mutation, C402S, prevented cross-l

53 In phase 2, the binding hits are multimerized by nanoparticle or proteoliposome display,

54 lfide-linked dimers and suggested that MUC5B multimerizes by disulfide linkage between D3-domains to

55 -Fc fusion proteins, which can be clustered (multimerized) by use of antibodies to form DDR2 complexe

56 r-associated factor (TRAF) proteins with the multimerized CD40 cytoplasmic domain.

57 When multimerized, CE1 conferred an osteoblast-specific activ

58 synthetic reporter construct controlled by a multimerized CEH-22 binding site.

59 strate that Ci can bring Su(fu) with it to a multimerized Ci DNA binding site.

60 ead of the conventional bait that contains a multimerized cis element.

61 Using monomers and multimerized complexes labeled with PE, we confirmed the

62 nucleases resulted in the disruption of the multimerized complexes.

63 etween the closed conformation and the open, multimerized conformation of L1.

64 Multimerized copies of either half of the repeat were Ta

65 Moreover, a multimerized copy of either SME-1 or SME-4 subcloned 5'

66 Finally, we have shown that a multimerized copy of SME-4 (bp -190 to -110) when linked

67 In contrast, a multimerized copy of the c-fos SRE is totally inactive i

68 asR demonstrated that the ability of LasR to multimerize correlates with its ability to function as a

69 ening of the skeletal muscle cDNA library by multimerized CSS-DNA as probe.

70 Multimerized de209 enhances transcription similarly to D

71 ycosylphosphatidylinositol (GPI) anchor that multimerizes despite the absence of the TMD.

72 ression and a conserved sequence, which when multimerized directs expression in a broad subset of neu

73 omain is joined to a C-terminal effector and multimerizing domain.

74 an intrinsic ability to dimerize (dsRBM2) or multimerize (dsRBM1).

75 Gag proteins must extensively multimerize during the formation of the spherical immatu

76 Our results indicated that pp28 multimerized during viral infection and that interacting

77 ion of a reporter gene located downstream of multimerized e5, PRS-9, or CD19 DNA-binding sites in thr

78 Here, we demonstrate that multimerized EEs are necessary and sufficient to confer

79 FliM does not multimerize efficiently by itself but does so in the pre

80 the N-terminal cytosolic tail are stable and multimerize efficiently, but are mislocalized to the end

81 or elements (NREs) could not be generated by multimerizing either the palindromic (P) Nru motifs alon

82 on of a reporter gene under the control of a multimerized element fused to an IL-4 minimal promoter.

83 Transgenic mice carrying the intronic multimerized enhancer drove high expression of a betaGeo

84 xes, optimal B cell-responses are induced by multimerized FDC-ICs that simultaneously engage multiple

85 e, monodisperse monomer but can be forced to multimerize following lyophilization and resuspension.

86 disease induced by T cell self-epitopes in a multimerized form (oligomers) is mediated by the inducti

87 enhanced if administered to the animal in a multimerized form as a T cell epitope oligomer (i.e., as

88 ted von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycopr

89 cantly influences the anti-viral activity of multimerized forms of SP-D.

90 However, multimerized forms of the combined P plus I elements rec

91 te at the protein-protein interface, and (2) multimerize further to generate a tetrameric quaternary

92 tems largely from ionic interactions between multimerized Gag and negatively charged phospholipids.

93 d transcription of a reporter gene driven by multimerized GATA4-binding DNA elements.

94 ivation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of ox

95 y controlled by septins - a unique family of multimerizing GTPases that associate with microtubules a

96 in which the zonula occludens (ZO) proteins multimerize has implications for the protein networks th

97 partitioning can be bypassed by artificially multimerizing HMGCRs, indicating NVJ compartmentalizatio

98 Short forms of Homer, which cannot self-multimerize (Homer 1a and a Homer 2 C-terminal deletion)

99 A multimerized hypoxia-responsive enhancer was constructed

100 hybrid results and suggesting that Pbp1p can multimerize; (iii) DIG1, encoding a mitogen-activated pr

101 Highly multimerized immunogens preferentially rapidly activated

102 CXCR4 was found to multimerize in cell lysates containing the detergents CH

103 ALLINIs multimerize IN protein and concordantly block its assemb

104 sulted in the loss of the ability of pRNA to multimerize in solution, consistent with the hypothesis

105 ts A30P and A53T, show similar tendencies to multimerize in the presence of PUFAs.

106 reas phosphomimicking mutations allow Cnn to multimerize in vitro and to spontaneously form cytoplasm

107 riments demonstrate that Mus81-Mms4 does not multimerize in vivo.

108 pressed with PPCA and beta-galactosidase, it multimerized in a complex of approximately 1350 kDa, tog

109 the RNA-binding domain, which appears to be multimerized in some DAZ proteins.

110 oskeleton-matrix interactions, appears to be multimerized in vivo.

111 Together, our results indicate that APOBEC3G multimerizes in an RNA-dependent fashion and that RNA-AP

112 a Ca(2+)-dependent pore-forming protein that multimerizes in membranes, delivers granzymes into the t

113 In the crystal, the molecule multimerizes in the form of a left-handed superhelix.

114 Our results show that Rev multimerizes in the nucleolus of living cells, suggestin

115 At high concentrations, perforin multimerizes in the plasma membrane to form pores.

116 r glycoprotein of approximately 330 kDa that multimerizes in the presence of calcium.

117 nstrate for the first time that human SUMO-1 multimerizes in vitro primarily via three N-terminal lys

118 the SynthOMIC approach (synthesis of ORFs by multimerizing in-frame codons), representative libraries

119 in the human promoter, but that an upstream multimerized insulin response sequence (IRS) motif that

120 study finds that archaeal histone dimers can multimerize into extended superhelical structures that m

121 s, type 1 (HIV-1) assembly, Gag polypeptides multimerize into immature HIV-1 capsids.

122 of putative capsid proteins that we predict multimerize into pentagonal and hexagonal arrays.

123 lical coiled-coil dimers; these subsequently multimerize into thick filaments via electrostatic inter

124 w that SHE complexes have a defined size but multimerize into variable particles upon binding of RNAs

125 The seven-subunit THO-UAP56/DDX39B complex multimerizes into a 28-subunit tetrameric assembly, sugg

126 PrgH multimerizes into a distinct tetrameric-shaped structure

127 In vivo, calsequestrin multimerizes into filaments, but there is not yet an ato

128 e tracking indicated that this core molecule multimerizes into higher-order particles.

129 energy transfer (FRET) that alpha-synuclein multimerizes into large homomeric complexes upon membran

130 However, multimerized intronic repeats inhibited calcitonin-speci

131 f additional regions containing low-affinity multimerized IRF sites and composite IRF-AP-1 sites, whi

132 The ability to multimerize is associated with a sequence close to the C

133 e have focused on one such element that when multimerized, is sufficient in mediating both activation

134 ction of the promoter by TGF-beta1 and, when multimerized, is sufficient to transfer TGF-beta1 induci

135 is necessary for enhancer activity and when multimerized it is sufficient to direct a kreisler-like

136 riptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents

137 Normally, multimerized Labial-PBC binding sites are sufficient to

138 /beta-catenin from a synthetic promoter with multimerized LEF/TCF binding sites and a natural cyclin

139 ion of ligand-receptor interactions, because multimerized ligands can enrich for cells expressing low

140 lf a bona fide transcriptional activator, as multimerized LR1 sites produce an element which can enha

141 and HIV-1 Gag proteins were more similar to multimerized MA than to monomeric MA.

142 The multimerized mammary-specific enhancer of MMTV on its ow

143 a human A-myb expression vector activated a multimerized MBS element-driven reporter construct appro

144 sion vector down-regulated the activity of a multimerized MBS element-driven reporter construct in SM

145 ization strategies to elicit HIV bNAbs using multimerized mEnv.

146 In this study, multimerized MHC-Ig fusion proteins, with a covalently a

147 The specificity and avidity of multimerized MHC-peptide complexes suggests their potent

148 ine zipper sequence from HIV-1 is capable of multimerizing much larger and otherwise monomeric protei

149 Artificially multimerized NC domains did not specifically bind Psi.

150 Similarly, multimerized NF-kappaB sites enhanced nucleosome binding

151 sactivates a minimal promoter which contains multimerized Nkx-2 DNA-binding sites.

152 oter and a minimal promoter, containing only multimerized Nkx-2.5 DNA binding sites (NKEs), in hetero

153 al gradient formation, whereas those bearing multimerized nonbulged lin-4 binding sites do not form a

154 nstrated that N528S-VWF was neither normally multimerized nor trafficked to storage granules.

155 s thymidine kinase (tk) promoter, or linking multimerized ntcp GLEs either upstream of the ntcp minim

156 reduce the enhancer-blocking activity of the multimerized oligonucleotides.

157 n also confers on it the ability to bind and multimerize on nonspecific double-stranded DNA.

158 ble monomers in the extracellular milieu and multimerize on target cell membranes.

159 GT121 inferred-germline B cells ex vivo when multimerized on liposomes, and primed PGT121-like respon

160 When multimerized on nanoparticles, this immunogen (eOD-GT6)

161 We used a V3-glycan immunogen multimerized on virus-like particles (VLPs), followed by

162 vitro binding studies of ELAV show that ELAV multimerizes on the ewg binding site and forms a defined

163 When multimerized, one of these sites activates the heterolog

164 e RcpA and RcpB abundances, and RcpA did not multimerize or localize to the outer membrane without th

165 edly increased when this oligonucleotide was multimerized or flanking sequences were added.

166 palindromic element or "simple GRE" that is multimerized or linked tightly with an AP1 site.

167 ansfected reporter constructs that contain a multimerized PEPCK IRE or an IGFBP-1 IRE and this stimul

168 Combined with the finding that levels of multimerized PiIQ were greatly reduced in PilP- mutants,

169 Multimerized Pita sites block iab-6<-->iab-7 crosstalk b

170 equired for cooperative binding of PLZF to a multimerized PLZF-RE.

171 The development of multimerized probes containing Ags, peptide:MHC complexe

172 provides an easy route to anchor, bridge or multimerize proteins.

173 the SunTag provides a versatile platform for multimerizing proteins on a target protein scaffold and

174 n PU.1 function is assayed in isolation on a multimerized PU.1 binding site, BSAP targets a portion o

175 in of PU.1 that activates transcription from multimerized PU.1 binding sites is not required to activ

176 nd sufficient to mediate the expression of a multimerized RCSI reporter, a marker of photoreceptor ce

177 cular gammadelta TCR, we demonstrated that a multimerized recombinant form of this gammadelta TCR can

178 NA-LP also stimulates EBNA-2 activation of a multimerized regulatory element from the BamC EBNA promo

179 n protein binding were not detected by using multimerized repeats.

180 We show that, whereas a multimerized response element from the germline IgE prom

181 ously, but in transient-transfection assays, multimerized RFX binding sites in front of a basal promo

182 A multimerized SBE promoter responsive to TGF-beta1 signal

183 Because soluble Env trimers or multimerized scaffolded epitopes are best at activating

184 , in particular, soluble gp140 trimers and a multimerized, scaffolded epitope protein.

185 ivation was not modulated by the presence of multimerized SCIP binding sites, and squelching was not

186 that neutrophils presented with immobilized multimerized Siaalpha2-3Galbeta1-4GlcNAc units engage th

187 as well as MRF-directed transcription from a multimerized skeletal muscle E-box reporter gene (4Rtk-l

188 transcription of a reporter gene containing multimerized Smad binding sites These cofactors interact

189 ited more potent neutralizing responses than multimerized SOSIP proteins.

190 brane anchors are not merely anchors but can multimerize specifically to activate signaling receptors

191 h the VIP CyRE and more specifically through multimerized STAT-binding sites.

192 erleukin-8 promoter or a promoter containing multimerized synthetic estrogen response elements were u

193 These multimerized tags, with translational enhancers, display

194 lt transgenic reporter constructs containing multimerized TCF binding sites.

195 ally, three caveats to the interpretation of multimerized TCF reporter expression patterns will be pr

196 However, multimerized TCF reporters should not be assumed to give

197 riments suggest that Mto1/2 multimers act to multimerize the fission yeast gamma-tubulin small comple

198 oplasmic accumulation of intronless mRNA, we multimerized the most conserved CAR-E and inserted it up

199 ly boundary activity can be reconstituted by multimerizing the Elba recognition site.

200 By multimerizing the MDB domain of Mbd1, we engineered a po

201 Multi-segmented viruses often multimerize their genomic segments to ensure efficient a

202 egarding the propensity of these proteins to multimerize, their subcellular distribution and mechanis

203 Moreover, if Fgd1 is multimerized, then cortactin's activity should be enhanc

204 Exon junction complexes can multimerize through ALYREF, which suggests a mechanism f

205 AFAP-110 binds actin filaments directly and multimerizes through a leucine zipper motif.

206 During HIV-1 assembly, Gag polypeptides multimerize to form an immature capsid and also package

207 CpG-A, but not CpG-B, can multimerize to form exceedingly large lattices.

208 es target to the plasma membrane, where they multimerize to form immature capsids that undergo buddin

209 Once activated, how BAK homodimers multimerize to form the putative apoptotic pore is unkno

210 These dimers multimerize to higher-order oligomers via a labile inter

211 ingle heavy chain domain that can be readily multimerized to engage antigen via multiple interactions

212 bine into a soluble, 7 S heterodimer that is multimerized to form the microtubule filament.

213 ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers.

214 Although TRIM5alpha multimerizes to form cytoplasmic bodies, which are thoug

215 ate protein dimerization, and the CA protein multimerizes to form the core retroviral and retrotransp

216 , this work supports a model in which Hermes multimerizes to gather enough BED domains to find its le

217 A multimerized TR as found in the viral genome results in

218 CD40 cross-linking probably multimerizes TRAF proteins which may act as direct trans

219 ion tagging using T-DNA vectors that contain multimerized transcriptional enhancers from the cauliflo

220 ctivator, suggesting that dimers of TraM can multimerize TraR.

221 A minimal multimerizing Tsg101 domain is a dominant negative inhib

222 rse in structure, share a common property of multimerizing tubulin, thus acting as polymerization cha

223 stimulation of a minimal promoter containing multimerized VCAM-1 NF-kappaB sites was inhibited by DN-

224 The represented nanostructure consists of multimerized VEGF(165) aptamer joint with ssDNA based li

225 ral murine alpha2(I) collagen promoter and a multimerized version of the proximal NF-Y(CBF) CCAAT box

226 Immunization with a multimerized version of this anti-idiotype induced the p

227 h protein, and that the ability of TRIM25 to multimerize via its RING domain augments ZAP activity an

228 The ability of MD-2 to multimerize was confirmed, and MD-1 was also shown to po

229 isoforms were found in their propensities to multimerize where only the longer isoforms 2 and 3 of th

230 responses and protein binding properties of multimerized wild-type and mutant elements added upstrea

231 and FoxP4 are coexpressed, can dimerize and multimerize with each other and differentially regulate

232 Based on the ability of DeltaBAFF to multimerize with full-length BAFF and to limit BAFF prot

233 ion of the nuclease domain and sufficient to multimerize with full-length WRN in human cells.

234 Unexpectedly, we find that endogenous EJCs multimerize with one another and with numerous SR protei

235 We reveal that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivit

236 Moreover, variants multimerize with, and upregulate, GluN2Bwt-subunits, thu

237 ragment of HeT-A and/or TART Gags, TAHRE Gag multimerizes with either protein.

238 ds, while NLRC4 is a downstream adaptor that multimerizes with NAIPs to form an inflammasome.

239 ominant negative effect on NAB repression by multimerizing with native NAB proteins and preventing bi

240 le tools have been designed which consist of multimerized Wnt signaling response elements (TCF/LEF bi