ライフサイエンスコーパス: multinucleate

1 ell density than wild type cells, tend to be multinucleate, accumulate normal levels of mass and prot

2 n these microfluidic eddies, where they form multinucleate aggregates and accumulate foci of the HDA-

3 Physarum polycephalum is a large multinucleated amoeboid cell that extends and develops p

4 point toward the involvement of KRP6 in the multinucleate and acytokinetic state of giant cells.

5 the lab, P. mirabilis cells become long and multinucleate and increase their number of flagella as t

6 In addition to illuminating multinucleate and multigenomic lifestyles, the adaptatio

7 Skeletal muscle contains long multinucleated and contractile structures known as muscl

8 duction of distal fine processes, and become multinucleated and hypertrophic.

9 tic constructs exhibit aligned architecture, multinucleated and striated myofibers, and a Pax7(+) cel

10 macrophages/monocytes based on the number of multinucleated and tartrate-resistant alkaline phosphata

11 matic polyploid cells can be mononucleate or multinucleate, and the replicated sister chromatids can

12 which then leads to the facile formation of multinucleate bone-resorbing giant cells.

13 ssed at these sites, where they fuse to form multinucleated bone-resorbing cells.

14 were enlarged, poikilocytic, and frequently multinucleated, but were able to sustain life despite ex

15 ell cycle, whereas other nuclei, in the same multinucleate cell, cycle normally, accumulating and deg

16 llular host tissues into a single contiguous multinucleate cell.

17 s syncytins forms the syncytiotrophoblast, a multinucleated cell structure essential for fetal develo

18 ly fusion active and led to the formation of multinucleated cell syncytia when expressed in the absen

19 rporates as many as 200 cells into one large multinucleated cell.

20 division without cytokinesis, resulting in a multinucleated cell.

21 embryo lethality, morphological defects, or multinucleate cells [2, 3].

22 These multinucleate cells are remarkable in that nuclei cycle

23 Multinucleate cells arose through aberrant division of b

24 Wee1 homolog Swe1 prevents the formation of multinucleate cells by restraining M phase CDK activity

25 The multinucleate cells resembled the syncytia caused by phy

26 fects, including the formation of elongated, multinucleate cells, failure to maintain the cytokinetic

27 causes an increased number of binucleate and multinucleate cells, suggesting that the kinase activity

28 Using a cell fusion approach to generate multinucleate cells, we investigate the effects of check

29 s highly clustered in the cytoplasm of large multinucleate cells.

30 ut retract prior to completion, resulting in multinucleate cells.

31 leads to the loss of nuclei and formation of multinucleate cells.

32 als, mandibles and tibiae were isolated, and multinucleated cells (MNCs) were measured.

33 The formation of multinucleated cells (syncytia) is a hallmark of henipav

34 eficient, OCRL prevented the accumulation of multinucleated cells after acute knockdown of OCRL but c

35 exhibited an increase in both the number of multinucleated cells and cells with swollen flagellar po

36 Its failure leads to multinucleated cells and is a possible cause of tumorige

37 tartrate-resistant acid phosphatase-positive multinucleated cells and measuring the expression of ost

38 nhibition of Aurora B by hesperadin produced multinucleated cells and reduced H3S10 phosphorylation.

39 lonogenic outgrowth, and high percentages of multinucleated cells are found in vivo in remnants of PA

40 Multinucleated cells are important in many organisms, bu

41 Multinucleated cells are relatively resistant to classic

42 lure in mitotic exit, with the appearance of multinucleated cells as a consequence.

43 confirmed by immunofluorescence staining on multinucleated cells at the bone surface of inflamed mou

44 ure of HPCs manifested by an accumulation of multinucleated cells caused by failed abscission of the

45 Giant multinucleated cells containing nuclei attached by const

46 PARP-inhibitor-induced multinucleated cells fail clonogenic outgrowth, and high

47 eventual degeneration with the formation of multinucleated cells following Cx43 overexpression due t

48 with occasional pseudonuclear inclusion and multinucleated cells in a partly myxoid matrix.

49 The formation of fused multinucleated cells in ganglia might be associated with

50 nesis was assessed by counting TRAP-positive multinucleated cells in PB CD14+ monocytes cultured with

51 Skeletal muscle consists of multinucleated cells in which the myonuclei are evenly s

52 osophila larval skeletal muscles are single, multinucleated cells of different sizes that undergo tre

53 Osteoclasts are multinucleated cells of the monocyte/macrophage lineage

54 tartrate-resistant acid phosphatase-positive multinucleated cells or resorption pits were observed in

55 ing the transport of nuclear proteins within multinucleated cells remain poorly defined.

56 Other subcellular effects observed included multinucleated cells seen after RNAi to either pgant2 or

57 are not optimized for capturing very large, multinucleated cells such as myotubes.

58 Myofibers are multinucleated cells that are formed, repaired and maint

59 cell fusion to form the fully differentiated multinucleated cells that mediate bone resorption.

60 a 40% growth decrease and the appearance of multinucleated cells that result from defective cytokine

61 ty of the population emerges from mitosis as multinucleated cells that subsequently undergo cell deat

62 sis and remarkably, elicits the formation of multinucleated cells that then arrest or die by mitotic

63 RANKL immunolabeling and fewer TRAP-positive multinucleated cells were observed in the EA-treated gro

64 matrix are all promoted by myosin-II, and so multinucleated cells with distended membranes--typical o

65 pletion generates supernumerary centrosomes, multinucleated cells, and multipolar spindle formation.

66 g, resulting in cell flattening, senescence, multinucleated cells, decreased S-phase progression, dim

67 dges, micronuclei, centrosome amplification, multinucleated cells, gradual accumulation of DNA damage

68 mitotic phase with the formation of abnormal multinucleated cells, indicating that this compound affe

69 sion led to a highly significant increase of multinucleated cells, nuclear volume, and 3D telomeric a

70 ates that included death, fusion that formed multinucleated cells, or another round of mitosis with n

71 -zoster virus (VZV) characteristically forms multinucleated cells, or syncytia, during the infection

72 Cs to overexpress NS decreases senescent and multinucleated cells, restores morphology, and antagoniz

73 Finally, we find that, in multinucleated cells, scaling is set at the level of sin

74 formation of long intercellular bridges and multinucleated cells, which might explain part of the Co

75 nockdown of I-2 by RNA interference produced multinucleated cells, with supernumerary centrosomes, mu

76 aa3 expression peaked prior to appearance of multinucleated cells.

77 rs abscission and increases the incidence of multinucleated cells.

78 otic errors ensued, producing aneuploid, and multinucleated cells.

79 o undergo proper cytokinesis and resulted in multinucleated cells.

80 nd pleiotropic tendencies largely made up of multinucleated cells.

81 mononuclear preosteoclasts fuse to generate multinucleated cells.

82 n of GEFs in the morphological maturation of multinucleated cells.

83 s, resulting in the accumulation of enlarged multinucleated cells.

84 ng HEK293 cells resulted in the formation of multinucleated cells.

85 f cell membranes are overcome and cells form multinucleated cells.

86 l size, but does this relationship extend to multinucleated cells?

87 onstrated specific expression of the gene in multinucleate cellular masses and layers at the materno-

88 Multinucleate cellular syncytial formation is a hallmark

89 ophyte in the unfertilized ovule, leading to multinucleate central cells at high frequency.

90 of lethality was less than the frequency of multinucleate central cells, indicating that these aspec

91 Polyploidal giant cancer cells (PGCCs) are multinucleated chemoresistant cancer cells found in hete

92 rated more slowly and about 10% of them were multinucleated compared with fewer than 2% of matched co

93 an enzymatic electrode, due to the use of a multinucleated complex of manganese with mu-oxo units, w

94 ow, 100 individual papillar cells assemble a multinucleate cytoplasm, allowing passage of proteins of

95 ting a multicellular epithelium into a giant multinucleate cytoplasm.

96 ny formation, invasion, and development of a multinucleated dendritic-like phenotype.

97 In multinucleated Dictyostelium discoideum cells, each cent

98 el across the ventral membrane of oversized, multinucleated Dictyostelium discoideum cells.

99 ion of those cells that do divide are either multinucleated, display deformed nuclei, or undergo cell

100 epletion causes centrosome amplification and multinucleate division, but replication stress indirectl

101 r et al. (2019) examine scaling of nuclei in multinucleated Drosophila muscle fibers and identify glo

102 rich medium on an agar surface, they become multinucleate, elongate, synthesize large numbers of fla

103 grin-linked kinase (ILK) caused formation of multinucleate epidermal cells within the Drosophila larv

104 Syncytiotrophoblast is the multinucleated epithelium of the placenta.

105 a cells, consistent with appearance of large multinucleated erythroblasts in CDA III patients.

106 erythropoiesis characterized by increased bi/multinucleated erythroid precursors in the bone marrow.

107 erodera glycines) induces the formation of a multinucleated feeding site, or syncytium, whose etiolog

108 y endoparasites that induce the formation of multinucleated feeding structures termed syncytia in the

109 bundant in muscles undergoing fusion to form multinucleated fibers and that enforced expression of GR

110 myogenic progenitors were specified to form multinucleated fibers that enabled development of quiesc

111 Each Drosophila larval muscle is a single multinucleated fibre whose morphology reflects expressio

112 We propose that the multinucleated filament creates an environmental niche w

113 In the multinucleate filamentous fungus Ashbya gossypii, the RN

114 acrophages from Xid mice also failed to form multinucleated foreign body giant cells.

115 al demonstrated an intimate association with multinucleated foreign body-type giant cells.

116 3D imaging of GEMs in the context of large, multinucleate fungi where there is evidence of functiona

117 We use a dynactin mutant strain of the multinucleate fungus Ashbya gossypii with highly cluster

118 in naturally occurring syncytia, such as the multinucleate fungus Ashbya gossypii.

119 We examined ploidy in a naturally multinucleate fungus, Ashbya gossypii.

120 ro to certain phthalate plasticizers exhibit multinucleated germ cell (MNG) induction and suppressed

121 ine), maternal hepatotoxicity, and increased multinucleated germ cells (MNGs) in fetal testes without

122 is their ability to induce the formation of multinucleate giant cells (MNGCs) in multiple cell types

123 es developed granulomatous inflammation with multinucleate giant cells, accompanied by increased accu

124 ores develop granulomatous inflammation with multinucleate giant cells, accompanied by increased accu

125 nt did not exhibit signs of cytopathology or multinucleated giant cell (MNGC) formation, which were o

126 ed giant cells (LGCs) are a specific type of multinucleated giant cell containing a characteristic ho

127 ically, I-PGCG was associated with: 1) lower multinucleated giant cell count (P = 0.04); 2) lower den

128 ntercellular signaling mechanisms modulating multinucleated giant cell formation and function are nec

129 targets for the modulation and inhibition of multinucleated giant cell formation and function.

130 173Q mutation enhanced viral replication and multinucleated giant cell formation upon infection of rh

131 inding, evidence of actin-based motility and multinucleated giant cell formation were observed betwee

132 correlated with IL-15 treatment and LGC-type multinucleated giant cell formation.

133 miR-7a-1 functions to regulate IL-4-directed multinucleated giant cell formation.

134 he tssE mutants lacked the ability to induce multinucleated giant cell formation.

135 precursors, other cell types can generate a multinucleated giant cell phenotype with bone resorbing

136 Langhans multinucleated giant cells (LGCs) are a specific type of

137 Multinucleated giant cells (MGCs) are implicated in many

138 peritoneal foam cells formed up to 45% more multinucleated giant cells (MGCs) in vitro compared to W

139 rophage fusion resulting in the formation of multinucleated giant cells (MGCs) is a multistage proces

140 The function of osteoclasts (OCs), multinucleated giant cells (MGCs) of the monocytic linea

141 ental macrophages spontaneously matured into multinucleated giant cells (MGCs), a property not exhibi

142 xtensive emperipolesis of lymphocytes within multinucleated giant cells (MGCs), MGC death, and fibrin

143 ound dying adipocytes, and the occurrence of multinucleated giant cells (MGCs).

144 atory lesions, monocytes fuse to form large, multinucleated giant cells (MGCs).

145 ame time promoting macrophage fusion to form multinucleated giant cells (MNG).

146 is is the formation of granulomas containing multinucleated giant cells (MNGCs) and cell death.

147 host cell and to stimulate the formation of multinucleated giant cells (MNGCs).

148 stimulated to limitless differentiation into multinucleated giant cells and provide useful suggestion

149 parenchymal, noncaseating granulomas lacking multinucleated giant cells and, in 1 patient, CD68-posit

150 Multinucleated giant cells are formed by the fusion of m

151 We found that multinucleated giant cells are formed in the inflamed mo

152 Abnormal multinucleated giant cells are present in the bone marro

153 r macrophages that comprise SIVE lesions and multinucleated giant cells are present in the CNS early,

154 ons with numerous SIV-p28(+) macrophages and multinucleated giant cells had fewer MAC387(+) monocytes

155 RAW 264.7 macrophages and was unable to form multinucleated giant cells in this cell line.

156 Cellular fusion of macrophages into multinucleated giant cells is a distinguishing feature o

157 acrophage fusion leading to the formation of multinucleated giant cells is a hallmark of chronic infl

158 rophage fusion resulting in the formation of multinucleated giant cells occurs in a variety of chroni

159 acrophage fusion leading to the formation of multinucleated giant cells remains unclear.

160 fficiently degrade mineralized tissue, these multinucleated giant cells secrete acid into a resorptio

161 Mature osteoclasts are multinucleated giant cells that are generated from the f

162 BI2536-treated LNCaP-AI cells formed multinucleated giant cells that contain clusters of nucl

163 Osteoclasts are multinucleated giant cells that resorb bone, ensuring de

164 from the seminiferous tubules, forming large multinucleated giant cells that underwent apoptosis.

165 The percentage of multinucleated giant cells was lower in brain-injured pa

166 s, parenchymal microglia are infected as are multinucleated giant cells when present.

167 On the remaining surface, multinucleated giant cells with varying intensity of tar

168 granulomatous inflammation characterized by multinucleated giant cells, some of which displayed elas

169 s, confer hyperfusogenicity on HSV and cause multinucleated giant cells, termed syncytia.

170 B. pseudomallei adheres, invades, and forms multinucleated giant cells, ultimately leading to cell t

171 ogy, with disrupted seminiferous epithelium, multinucleated giant cells, uncleared apoptotic germ cel

172 d clearance of amyloid by macrophage-derived multinucleated giant cells.

173 onocytes that transform into macrophages and multinucleated giant cells.

174 d, to a lesser extent, epithelioid cells and multinucleated giant cells.

175 e formation and function of various types of multinucleated giant cells.

176 d fusion of macrophages and the formation of multinucleated giant cells.

177 ted the cells ability to form TRAP positive, multinucleated giant cells.

178 d to the differentiation of macrophages into multinucleated giant osteoclasts and their bone resorpti

179 M) mice) leads to super spread morphology of multinucleated giant osteoclasts with elevated bone reso

180 redominantly undifferentiated), induction of multinucleated gonocytes (MNGs), and aggregation of diff

181 organs showed congestions, aggregations and multinucleated hepatocytes in the liver, infiltration of

182 ween nuclei within the common cytoplasm of a multinucleate heterokaryon.

183 These include a front of large, multinucleate leader cells, trailed by follower cells th

184 lls (FBGCs) are inflammatory and destructive multinucleated macrophages and may cause damage and/or r

185 asmic domains, resulting in the formation of multinucleate microspores.

186 Cpd A prevents cytokinesis, resulting in multinucleated, multiflagellated cells that eventually l

187 dhesion and fusion between myoblasts to form multinucleate muscle fibers, have been conserved in the

188 f proliferating progeny from differentiated, multinucleated muscle cells by first inducing and subseq

189 essary at multiple steps in the formation of multinucleated muscle cells.

190 o system to analyze nuclear scaling in whole multinucleated muscle fibers, genetically manipulate ind

191 es apoptosis of a subset of myonuclei within multinucleated muscle fibers.

192 raveling the intrinsic regulation of size in multinucleated muscle fibers.

193 toplasmic puncta at the nuclear periphery in multinucleated myoblasts, and that this change in locali

194 ere is also evidence for self-duplication of multinucleated myocytes, suggesting a more complex pictu

195 rsity and whether individual nuclei within a multinucleated myofiber might respond differentially to

196 ndependent mechanism) the formation of large multinucleate myofibers.

197 y cycles of degeneration and regeneration of multinucleated myofibers and pathological activation of

198 Fusion of individual myoblasts to form multinucleated myofibers constitutes a widely conserved

199 eletal muscle, which is composed of numerous multinucleated myofibers formed by the fusion of progeni

200 erved process that leads to the formation of multinucleated myofibers, syncytiotrophoblasts and osteo

201 ell as their differentiation and fusion into multinucleated myofibers, which are greatly reduced in m

202 n occurs through fusion of myoblasts to form multinucleated myofibers.

203 es fusion of mononucleated myoblasts to form multinucleated myofibers.

204 l muscle development, myoblasts fuse to form multinucleated myofibers.

205 t of skeletal muscle in all metazoans is the multinucleate myofibre, within which individual nuclei a

206 from the fusion of precursor myoblasts into multinucleated myofibres.

207 Formation of multinucleate myotubes by SMN-deficient muscle cells is

208 d to show the expected increase in fusion to multinucleate myotubes.

209 Multinucleated myotubes develop by the sequential fusion

210 hich arise from the fusion of myoblasts into multinucleated myotubes during myogenesis.

211 protein required for myoblast fusion to form multinucleated myotubes in mouse, chick, and zebrafish.

212 fferentiated myotubes, it induced fission of multinucleated myotubes into mononucleated fragments.

213 Myoblast fusion into multinucleated myotubes is a crucial step in skeletal mu

214 S proteinases contribute to the formation of multinucleated myotubes such as is necessary for both sk

215 During myogenesis, myoblasts fuse into multinucleated myotubes that acquire the contractile fib

216 Here we used primary chicken and duck multinucleated myotubes to examine their susceptibility

217 Conversely, myogenic differentiation into multinucleated myotubes was decreased when Pitx2 or Pitx

218 es fusion of mononuclear progenitors to form multinucleated myotubes, a critical but poorly understoo

219 d that their steady-state levels increase in multinucleated myotubes, suggesting a global increase in

220 muscle cells that differentiate into fused, multinucleated myotubes.

221 oles of Notch1 in mononucleated myocytes and multinucleated myotubes.

222 and 66+/-2% MD2 expression in differentiated multinucleated myotubes.

223 ciently drives myogenic differentiation into multinucleated myotubes.

224 ration requires the fusion of myoblasts into multinucleated myotubes.

225 the time when myoblasts were fusing to form multinucleated myotubes.

226 atic myoblasts prior to their fusion to form multinucleated myotubes.

227 dysferlin expression is increased in mature, multinucleated myotubes.

228 myogenesis as individual myoblasts fuse into multinucleated myotubes.

229 he fusion of mononucleated myoblasts to form multinucleated myotubes.

230 ry for the proper repair and regeneration of multinucleated myotubes.

231 with cytokinesis defects attributed to CIT, multinucleated neurons were observed throughout the cere

232 uber-like lesions containing cytomegalic and multinucleated neurons with abnormal dendritic trees res

233 The microcapsules were multinucleated, not very water-soluble or hygroscopic an

234 erodera glycines as it attempts to develop a multinucleate nurse cell (syncytium) serving to nourish

235 arrow monocytes (BMMs) to differentiate into multinucleated OCLs in response to exogenously supplied

236 the fusion of OC precursors and formation of multinucleated OCs and decreases bone matrix resorption.

237 equired for RANKL-induced formation of giant multinucleated OCs by up-regulating the expression of nu

238 t subset of cells that appeared to be either multinucleate or possessed multi-lobed nuclei that are n

239 ved macrophages (BMM), the formation of both multinucleated osteoclast and MNG induced by RANKL or IL

240 BMMs from MCP-1(-/-) mice showed decreased multinucleated osteoclast formation compared with WT mic

241 rived conditioned medium stimulated in vitro multinucleated osteoclast formation.

242 This correlated with fewer multinucleated osteoclast-like cells and more trabecular

243 , which increased their differentiation into multinucleated osteoclast-like cells.

244 n myeloma is characterized by an increase in multinucleate osteoclasts in close proximity to tumor ce

245 orm sphingosine 1-phosphate (S1P), in mature multinucleated osteoclasts as compared with preosteoclas

246 ntaining mature osteoblasts and formation of multinucleated osteoclasts in response to BMP-2.

247 ings that Darc-antibody blocked formation of multinucleated osteoclasts in vitro and that Darc from C

248 lls substantially inhibited the formation of multinucleated osteoclasts in vitro.

249 was correlated to the increased activity of multinucleated osteoclasts on the distal side of the mol

250 IL1 showed significantly fewer TRAP-positive multinucleated osteoclasts than EP and EP-Saline (P <0.0

251 gand (RANKL), these precursors formed large, multinucleated osteoclasts that expressed tartrate-resis

252 Bone-resorbing multinucleated osteoclasts that play a central role in t

253 KL) resulted in a robust formation of large, multinucleated osteoclasts which generated sealing zones

254 artrate-resistant acid phosphatase-positive) multinucleated osteoclasts, and the osteoclasts were sma

255 Galpha(13) is highly expressed in mature multinucleated osteoclasts, but not during early differe

256 NAs and proteins and impaired fusion to form multinucleated osteoclasts, defects secondary to diminis

257 ow that, while homozygous c-Fos mice have no multinucleated osteoclasts, heterozygous mice have a red

258 nificantly increased during the formation of multinucleated osteoclasts.

259 nsition from mononucleated preosteoclasts to multinucleated osteoclasts.

260 tment with CID755673 and restore fusion into multinucleated osteoclasts.

261 did not completely differentiate into mature multinucleated osteoclasts.

262 rentiation strongly decreased the numbers of multinucleated osteoclasts.

263 ether, lung cancer cells uniformly grew into multinucleated PGCCs.

264 letion of the NF90/NF45 complex results in a multinucleated phenotype.

265 in the absence of cytokinesis, resulting in multinucleated, polyploidy cells.

266 Muscle fibres are multinucleated post-mitotic cells that can change dramat

267 ble cross-over homologous recombination, but multinucleated R. oryzae could not be forced to segregat

268 rvived longer after mitotic arrest, becoming multinucleated rather than dying directly from mitotic a

269 Multinucleated Reed-Sternberg (RS) cells are pathognomon

270 enlarged cardiac myocytes, some of which are multinucleated, reflecting a defect in cytokinesis.

271 ased cell shedding and the presence of large multinucleated RPE cells, suggesting defects in intercel

272 Most mouse cardiomyocytes (CMs) become multinucleated shortly after birth via endoreplication a

273 Multinucleated skeletal muscle fibers form through the f

274 Myoblast fusion to form multinucleated skeletal muscle myotubes is a well studie

275 e extent of transcriptional diversity within multinucleated skeletal myofibers.

276 ring, and 19 asexual derivatives from single multinucleate sporangia demonstrates a high incidence of

277 nuclei and reproduce clonally through large multinucleated spores.

278 oth aneuploidy and polyploidy can arise from multinucleate states after failed cytokinesis or cell fu

279 The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscl

280 in cell membrane breakdown and formation of multinucleate syncytia.

281 how cells join together to form zygotes and multinucleated syncytia has remained a fundamental quest

282 A subset of infected cells formed multinucleated syncytia through HIV envelope-dependent c

283 neous fusion of infected cells to form large multinucleated syncytia.

284 nt is the fusion of trophoblast cells into a multinucleated syncytiotrophoblast (ST) layer.

285 totrophoblasts (CT) ends in formation of the multinucleated syncytiotrophoblast representing the feta

286 subsequently fuse, and differentiate to form multinucleated syncytiotrophoblast with induction of aro

287 hoblasts, including the transcriptome of the multinucleated syncytiotrophoblast.

288 their differentiation potential from TGCs to multinucleated syncytiotropholasts (SynTs) and blocks ox

289 ial layer (YSL) in the zebrafish embryo is a multinucleated syncytium essential for embryo developmen

290 Skeletal muscle is a multinucleated syncytium that develops and is maintained

291 filamentous fungus, Neurospora crassa, is a multinucleate system used to elucidate molecular mechani

292 r activator of NF-kappaB ligand formation of multinucleated tartrate-resistant acid phosphatase (TRAP

293 m 50 MF patients showed increased numbers of multinucleated tartrate-resistant acid phosphatase (TRAP

294 The number of multinucleated tartrate-resistant acid phosphatase-posit

295 tion of transcriptional heterogeneity within multinucleated tissues has been challenging due to the p

296 s and an increase in the formation of giant, multinucleated TRAP(+) cells capable of F-actin ring for

297 expression in mononuclear cells, but not in multinucleated TRAP(+) OC.

298 ar bone loss and reduced the total number of multinucleated TRAP+ cells in mice that received ligatur

299 e-marrow precursors that differentiated into multinucleated TRAP-positive cells in the presence of EP

300 MW-E-overexpressing cells are binucleated or multinucleated with amplified centrosomes, whereas EL-ov