ライフサイエンスコーパス: multiplicity

1 icant finding just by chance (the problem of multiplicity).

2 reactivity without a change in the net spin multiplicity.

3 6(-/-) mice, had a 10-fold increase in tumor multiplicity.

4 s an excited-state process with triplet spin multiplicity.

5 in the current article were not adjusted for multiplicity.

6 the distribution of nearby reads and mapping multiplicity.

7 in terms of mass-productivity and structural multiplicity.

8 ed in PSIP1-/- Jurkat cells infected at high multiplicity.

9 volving two (or potentially more) sources of multiplicity.

10 a single clinical trial without the risk of multiplicity.

11 identification of the ground state and spin multiplicity.

12 ion in a mouse model of cancer reduces tumor multiplicity.

13 level of alpha = .10 with no adjustments for multiplicity.

14 ted measures, and p values were adjusted for multiplicity.

15 upon the enzymatic treatment, revealed their multiplicity.

16 cited-state species as excitons with triplet multiplicity.

17 ultimately be overcome by infection at high multiplicities.

18 Multiplicity-adjusted P values for these associations we

19 Diabetes Association, was the prespecified, multiplicity-adjusted secondary outcome.

20 n pairwise comparisons between the 4 groups (multiplicity-adjusted thresholds for statistical signifi

21 erious adverse events (SAEs) within 90 days (multiplicity-adjusted thresholds for statistical signifi

22 All p values were one-sided and multiplicity-adjusted.

23 The Short Focus Level multiplicity adjustment can perform the full top-down ap

24 (P = 0.06 and P = 0.45, respectively, before multiplicity adjustment).

25 antage of the otherwise powerful Focus Level multiplicity adjustment.

26 : Commonly used multiplicity adjustments fail to control the error rate

27 The colons were analyzed for crypt multiplicity after 12 weeks of treatment.

28 ITAM multiplicity amplifies TCR signals, but the importance o

29 e entropy can be factored into a generalized multiplicity and a constraint term.

30 has implications for the evolution of origin multiplicity and associated controls, and may explain th

31 exhibited significantly decreased lung tumor multiplicity and attenuated pulmonary inflammation, whic

32 erical insights into critical issues such as multiplicity and binding.

33 We found that the incidence, multiplicity and burden of cSCC that form in Keap1(flox/

34 on of Egfr had significantly decreased tumor multiplicity and burden, protection from high-grade dysp

35 gy has provided greater understanding of the multiplicity and complexity of cellular networks involve

36 out elimination of nitrogen is determined by multiplicity and energy of the excited state, generated

37 Here, we analyzed tumor multiplicity and gene expression in tumor-prone Apc (Min

38 ed significant suppression of adenocarcinoma multiplicity and incidence with no toxicity compared to

39 /sclerotic or mixed), matrix mineralization, multiplicity and involvement of other sites.

40 VPA/hydralazine reduced mammary tumor multiplicity and lengthened tumor latency in HF offsprin

41 Furthermore, tumor multiplicity and malignant progression of papillomas aft

42 The functional multiplicity and mechanistic complexity of defensins und

43 Despite this simplification, the product multiplicity and novelty overwhelmed analytical efforts

44 We conclude that both the multiplicity and specific geometry of GM1 binding sites

45 s result of concomitant factors, such as the multiplicity and the different concentration of the comp

46 t is difficult to determine the true initial multiplicity and the dominant binary formation mechanism

47 years with regard to whether to correct for multiplicity and, if so, how it should be done.

48 Incidence, multiplicity, and location of tumors were visually count

49 rexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemicall

50 n existing familywise error rate controlling multiplicity approach (the Focus Level method) for gene

51 If statistical adjustments for multiplicity are applied, the rationale and method used

52 es the following different contexts in which multiplicity arises: testing for baseline differences in

53 The multiplicity associated with the nature of the neural co

54 These cores have the same multiplicity but different conformations.

55 in plus DFMO suppressed colon adenocarcinoma multiplicity by 76% compared to low-dose Rosuvastatin (2

56 Their multiplicity can be explained by the co-existence of mul

57 e a twofold increase in tumour incidence and multiplicity compared to controls.

58 te regressions, with those significant after multiplicity control by the Hochberg method reported.

59 e tested simultaneously require some sort of multiplicity correction to account for the multiplicity

60 Transcriptomic subtype multiplicity correlated with increased intratumoral hete

61 ations (4.4, 2.3-8.6), but age, sex, and CCM multiplicity did not add independent prognostic informat

62 f exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (M

63 NMR via C-H coupled and decoupled (1)H-(13)C multiplicity edited gHSQC, (1)H-(31)P HMBC, and dqfCOSY

64 f multiplicity correction to account for the multiplicity effect.

65 that E/Z photoswitching of 4TCE operates by multiplicity-exclusive pathways, enabling additional mea

66 ence of mural nodules, septations, or lesion multiplicity failed to demonstrate association with grow

67 ection in Bdellovibrio, documents protection-multiplicity for products of two different genomic loci,

68 mg ubrogepant group (P = 0.002, adjusted for multiplicity, for the comparison with placebo), and 21.2

69 ain-sequence multiplicity is higher than the multiplicity found in field stars, which suggests that d

70 This multiplicity has confounded efforts to simultaneously me

71 ay) significantly enhanced tumor penetrance, multiplicity, histologic dysplasia scores, and adenocarc

72 acrophages (MDM) efficiently transmit a high-multiplicity HIV-1 infection to autologous CD4(+) T cell

73 esigned promoters, we find that binding-site multiplicity in native promoters is associated with high

74 luded skin tumors, which displayed increased multiplicity in wild-type animals, and leukemias, which

75 ne-based activation motifs (ITAMs; high ITAM multiplicity) in the complex of the T cell antigen recep

76 s that have been proposed for correcting for multiplicity, including single-step procedures (e.g., Bo

77 deletion of Ccn1 suffer increased HCC tumor multiplicity induced by the hepatocarcinogen diethylnitr

78 sequence lineages could be explained by high multiplicity infection from a donor whose viral sequence

79 cant reductions in VACV growth following low-multiplicity infection.

80 permissive murine fibroblasts following low-multiplicity infection.

81 ve fibroblasts was partially rescued by high-multiplicity infection.

82 mplex model, with broad implications for the multiplicity inherent in signaling networks.

83 Although heterogeneity and multiplicity is a fundamental characteristic of biologic

84 nalysis to Broad and E74 and found that EcRE multiplicity is a general feature of the early genes.

85 Hemoglobin (Hb) multiplicity is common in fish, yet despite its ubiquito

86 show that protostellar and pre-main-sequence multiplicity is higher than the multiplicity found in fi

87 Here we demonstrate that ITAM multiplicity is important for the development of innate-

88 Interestingly, we observe that motif pairing multiplicity is linked to several characteristics such a

89 ivo, but the functional significance of this multiplicity is unknown.

90 Raman scattering offers high sensitivity and multiplicity, it cannot be readily used to image specifi

91 tatistical significance after adjustment for multiplicity (least squares mean difference, -0.2 [95% C

92 is not effective and tumor localization and multiplicity make surgery and radiosurgery challenging a

93 MDP treatment following infection at low multiplicity (MOI = 0.1 PFU/cell) inhibited HCMV in a do

94 the results indicate that in infections at a multiplicity near 1, HIV-1 reverse transcription is comp

95 GHOST-R5X4 cells, followed by infection at a multiplicity near unity with HIV-1 or an HIV-1-derived v

96 oltzmann-Gibbs-Shannon entropy is related to multiplicities of independent random processes.

97 ells infected with poliovirus at low or high multiplicities of infection (MOI) and measured viral gen

98 with HRV or UV-irradiated HRV at increasing multiplicities of infection (MOI) without or with IFN-be

99 pulations generated in environments with low multiplicities of infection (MOI), a phenomenon that may

100 were passaged in Vero cells at high and low multiplicities of infection (MOIs) for 11 generations an

101 control neutrophils (without antibiotic) at multiplicities of infection (MOIs) of 30 and 90 bacteria

102 than HMPV, with the latter requiring higher multiplicities of infection (MOIs) to yield similar leve

103 ult in cell death of most NPCs, even at high multiplicities of infection (MOIs); (ii) limited HSV-1 r

104 ood allelic discrimination and detected high multiplicities of infection in 63 P. vivax infections in

105 Infection of HPMECs with increasing multiplicities of infection of an adenovirus encoding fo

106 lated neutrophils were infected with varying multiplicities of infection of both viruses, and opsonop

107 In head-to-head infections at fixed multiplicities of infection, one SA13/JFH1orig mutant te

108 g-passaged populations was reduced at higher multiplicities of infection, suggesting the presence of

109 At low multiplicities of infection, wild-type virus yields are

110 d in PML(-/-) infected at low, but not high, multiplicities of infection.

111 roduct required for viral replication at low multiplicities of infection.

112 was both long lasting and detectable at low multiplicities of infection.

113 of MDP were observed following infection at multiplicity of 1.

114 One of the conclusions is that, despite the multiplicity of acceptable models, an overall structure

115 In addition, for multilocus traits, the multiplicity of alternative, functionally equivalent sta

116 people currently lacking them will require a multiplicity of approaches.

117 The multiplicity of beta:gamma combinations that can partici

118 The first shows the ways that a multiplicity of biophysical methods can be combined with

119 lex system of health-care production, with a multiplicity of causes.

120 ces in chromatin organization are key to the multiplicity of cell states that arise from a single gen

121 gic heterogeneity of CAVD, but also from the multiplicity of cell types that can participate in valve

122 s a complex inflammatory response in which a multiplicity of cell types, cytokines, and growth factor

123 e less curation time, are generalizable to a multiplicity of cell types, from bacteria to mammalian c

124 Here, the multiplicity of cellular infection (MOI) and population

125 However, the multiplicity of chemokines within tumours has obscured t

126 Collectively, our data demonstrate the multiplicity of clathrin functions in cortical pattern f

127 d multivariate data analysis, correction for multiplicity of comparisons with correlated data, and fi

128 ass formation in these systems arises from a multiplicity of competing local motifs, each of which is

129 btained using flow-based techniques, but the multiplicity of conventional IF is limited.

130 , a problem typically intractable due to the multiplicity of coordination environments found in many

131 The multiplicity of critical points in our model allows it t

132 The multiplicity of crowding was then tested with observers

133 Topics covered include: multiplicity of data, interpreting secondary endpoints a

134 The vmPFC signals a multiplicity of decision variables, the strength and pol

135 s, which serve a dual role by coordinating a multiplicity of enzymes as well as anchoring the microbe

136 asing binding affinity between partners, the multiplicity of evolutionary pathways between selectivel

137 cologically valid decision-making involves a multiplicity of factors acting simultaneously.

138 wever, due to the heterogeneity in size, the multiplicity of functional groups, and the highly convol

139 The multiplicity of gastric tumor in carcinogen-treated mice

140 o various GPCRs offers new insights into the multiplicity of genes for Gbeta and Ggamma, and the mech

141 The multiplicity of genes identified in the 571 subjects ref

142 ction of U(VI), this tool is applicable to a multiplicity of geological epochs and terrestrial enviro

143 tal structure can be obtained because of the multiplicity of geometrical isomers present.

144 It is the culmination of a multiplicity of heterogeneous disease states and their v

145 nts in pol sequence clusters, and to analyze multiplicity of HIV infection.

146 ce (P = 0.1) if Bonferroni corrected for the multiplicity of hypotheses tested (n = 8).

147 But how the unique L protein carries out the multiplicity of individual steps in these two distinct p

148 ecificity likely compensates for the lack of multiplicity of individual subunits, and helps to fine t

149 is within 48 h after exposure to low titers (multiplicity of infection > 0.07) of an African lineage

150 versity (pi = 2.4 x 10(-4)), moderately high multiplicity of infection (2.7), and low linkage disequi

151 zygosity, 0.843 [range 0.570-0.989] with low multiplicity of infection (mean, 1.05) reflecting a low

152 and complex: 67% polyclonal infections, mean multiplicity of infection (MOI) 2.2, and mean within-hos

153 ations, along with estimates of the cellular multiplicity of infection (MOI) and MOI model selection,

154 Multiplicity of infection (MOI) by Amp-Seq was 2.32 vers

155 has not been previously shown how the viral multiplicity of infection (MOI) can affect IFN induction

156 Multiplicity of infection (MOI) can be an indicator of i

157 e of F-pili from host cells, and that higher multiplicity of infection (MOI) correlates with detachme

158 However, infection at a low multiplicity of infection (MOI) in the presence of acycl

159 ned from healthy individuals and primed at a multiplicity of infection (MOI) of 10(2) with different

160 evident only at ~72 hpi at the corresponding multiplicity of infection (MOI) of 10.

161 49, and RAW 264.7 cells when inoculated at a multiplicity of infection (MOI) of 3 PFU/cell.

162 ted with herpes simplex virus 1 (HSV-1) at a multiplicity of infection (MOI) of 3 with the majority o

163 s were infected with the rAAV-CIP vectors at multiplicity of infection (MOI) of 5000, in the absence

164 n RAW264.7 and THP-1 macrophages infected at multiplicity of infection (MOI) of ~1.0.

165 that viruses can be transmitted at a higher multiplicity of infection (MOI) that, in vitro, results

166 phage-adapted chlamydiae correlates with the multiplicity of infection (MOI), and optimal chlamydial

167 f blood-stage parasites affects the observed multiplicity of infection (MOI), as well as the relation

168 efficiency than the wild-type virus at a low multiplicity of infection (MOI), but it grew similarly w

169 ate in noncomplementing cells, even at a low multiplicity of infection (MOI), though a reduction in t

170 false-negative rates especially with a high multiplicity of infection (MOI).

171 with herpes simplex virus 1 (HSV-1) at high multiplicity of infection (MOI).

172 seasonal influenza A (H1N1) viruses at a low multiplicity of infection (MOI; 0.0001 PFU/cell) or with

173 ng strain), or RSV (A/2001/2-20 strain) with multiplicity of infection 0.01 to 1.

174 Macrophages were exposed to HRV16 (multiplicity of infection 5), polyinosinic:polycytidylic

175 that the number of viruses infecting a cell (multiplicity of infection [MOI]) influences the magnitud

176 -to-cell contact and increased together with multiplicity of infection and HCV protein levels.

177 required a threshold level of SipA linked to multiplicity of infection and may be a limiting factor c

178 Furthermore, we observe that high multiplicity of infection can induce the conversion of L

179 o with varicella-zoster virus (VZV) at a low multiplicity of infection does not result in a cytopathi

180 ss between HIV strains in the cohort and the multiplicity of infection in seroconverters.

181 The multiplicity of infection is determined by the rate of n

182 ffective concentration (EC50) ranging from a multiplicity of infection of 0.01 to 0.1.

183 miRNAs was modulated 3 h postinfection (at a multiplicity of infection of 25).

184 bone marrow-derived in vitro cultures, high multiplicity of infection or the use of opsonized bacter

185 High multiplicity of infection passaging of both NiV clinical

186 g caution regarding the substantially higher multiplicity of infection seen in organ transplantation-

187 d normalized by the PreS1*-MOI, which is the multiplicity of infection that reflects the number of Pr

188 12 months and at sick visits were assessed; multiplicity of infection was evaluated by PCR that targ

189 assortants, suggesting that a uniformly high multiplicity of infection was not achieved in vivo.

190 yping demonstrated a significant decrease in multiplicity of infection within the first 2 days in bot

191 After enrollment, mixed infections (multiplicity of infection, >1) were only present in the

192 KK1 is important for HCMV infection at a low multiplicity of infection, but is dispensable for AMPK a

193 Finally, we show that at a low multiplicity of infection, either UL97 or UL21a can part

194 e of one strain (W3) in Vero cells at a high multiplicity of infection, under conditions of competiti

195 At a low multiplicity of infection, we observed only a small perc

196 the findings of a virus yield assay at a low multiplicity of infection.

197 were added to RPE and THP-1 cells with a 5:1 multiplicity of infection.

198 sages in cell culture of the virus at a high multiplicity of infection.

199 nnings of virus transmission, especially the multiplicity of infection.

200 us monocytes infected with adenovirus at low multiplicity of infection.

201 ransmission, resulting in an increase in the multiplicity of infection.

202 F and exhibits a replication defect at a low multiplicity of infection.

203 ll parasitemic individuals were assessed for multiplicity of infections by nPCR and gametocyte carria

204 The involvement of such a multiplicity of interfaces requires a tight control to e

205 abilistic topology of change that includes a multiplicity of lineage restriction trajectories.

206 The mouth presents a multiplicity of local environments in communication with

207 The multiplicity of markers, limited information on their in

208 on among treatment groups and the clustering/multiplicity of measurements within an individual.

209 so drives dysregulated cell growth through a multiplicity of mechanisms that include altering the act

210 Physically, it quantifies the multiplicity of metastable states in which an amorphous

211 Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events

212 Using a multiplicity of morphological, biochemical, functional,

213 This multiplicity of morphologies in the crimped scaffold wor

214 Recognizing that there is a multiplicity of motives - and that the accessibility and

215 d charitable acts are over-determined, and a multiplicity of motives should be considered in explaini

216 These results suggest that multiplicity of motors is required not only for transpor

217 To help resolve the multiplicity of observations, we gathered a group of res

218 We identified substantial heterogeneity and multiplicity of outcome selection and measurement in pub

219 epends on both the inter-DNA spacing and the multiplicity of parallel DNA ligands in the self-assembl

220 ndirect action of selection on GS, through a multiplicity of phenotypes and life-history traits.

221 ion are separable and are coordinated by the multiplicity of phosphorylated ITAMs in TCR-CD3.

222 Malate is a central metabolite involved in a multiplicity of plant metabolic pathways, being associat

223 -clinical neural impairment in the face of a multiplicity of potential risk factors, including disrup

224 have had limited success, likely due to the multiplicity of potential sources for recolonization.

225 may be a critical predictor of the size and multiplicity of precancerous lesions.

226 ssociation-based normalization, in which the multiplicity of prey (MOP) ratio needed to elicit half o

227 Fluorescence leads to a multiplicity of problems: one is noise, while another is

228 hanisms and neural substrates underlying the multiplicity of processes involved in motor learning.

229 NCE STATEMENT We offer new insights into the multiplicity of processes that are associated with angul

230 o be trapped in local conformations, and the multiplicity of protomer interfaces, makes the AXH domai

231 s comprise pore-forming alpha subunits and a multiplicity of regulatory proteins, including the cardi

232 dequate descriptions of pulse sequences, and multiplicity of reporting radiologists.

233 tudy of these protein tethers has revealed a multiplicity of roles in cell physiology, including regu

234 In this study, we used a model of low multiplicity of S. pneumoniae infection with HL-1 mouse

235 The LCA classified predominantly by type and multiplicity of sensitization (food vs inhalant), allerg

236 SeqGL successfully scales to the large multiplicity of sequence signals in DNase- or ATAC-seq m

237 s frequently up-regulated in human HCCs; the multiplicity of SETDB1 activating mechanisms at the chro

238 cal science that is informed and tested by a multiplicity of sociopolitical paradigms.

239 amily TAs, but more unusually occurring as a multiplicity of species-specific subtypes.

240 ergence to a unique fixed point, (ii) a huge multiplicity of stable fixed points, and (iii) chaotic b

241 aracterization is not trivial because of the multiplicity of states in the ensemble and rapid (micros

242 The initial multiplicity of stellar systems is highly uncertain.

243 en an E3 and its cognate E2 in governing the multiplicity of substrate ubiquitination.

244 pection because the scattered signals from a multiplicity of such elements would end up interfering w

245 Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains

246 In view of the multiplicity of target citrullinated autoantigens descri

247 vents that led to cytokine secretion, a high multiplicity of TCR-CD3 ITAMs was required for TCR-drive

248 Here we found that whereas a low multiplicity of TCR-CD3 ITAMs was sufficient to engage c

249 sex, and follow-up time (and correcting for multiplicity of tests), 89 proteins were found to be ass

250 Our data demonstrate multiplicity of Th2-cytokine control of eosinophil tissu

251 utic nanocarriers, where the combination and multiplicity of the affinity moieties utilized allow mod

252 eral previous motor learning studies and the multiplicity of the neural coding underlying visually gu

253 Our findings reveal the inherent multiplicity of the process of protein misfolding and th

254 The multiplicity of the productive excited states and the ro

255 of long-chain fatty acyl-CoAs because of the multiplicity of their cellular functions.

256 The multiplicity of these states confers many advantages for

257 GE) is a powerful approach for revealing the multiplicity of transcription start site (TSS) events ac

258 ved type 1 membrane proteins that initiate a multiplicity of transient gene transcriptions, resulting

259 latency and decreased both the incidence and multiplicity of UVR-induced SCC.

260 cated by the broad range of variables (e.g., multiplicity of varieties, pedo-climatic aspects, produc

261 We show that by continuously monitoring a multiplicity of vibrational modes, the spatial moments o

262 Understanding the multiplicity of ways in which sex can alter the brain is

263 (P = .001), cirrhosis (P = .007), and tumor multiplicity (P = .001).

264 cantly increased tumour size (P = 0.025) and multiplicity (P = 0.025), compared with control Apc (Min

265 clusters peak around 500 keV/mum, while DSB multiplicities per cluster steadily increase with LET.

266 ict the effects of knob density and receptor multiplicity per knob on rolling adhesion of schizonts.

267 Here we explore the hypothesis that Hb multiplicity plays a role in hypoxia tolerance using the

268 often average over these dynamics and their multiplicity, preventing identification of the molecular

269 propagation of the viral population through multiplicity reactivation under conditions of widespread

270 unctions, but the biological reason for this multiplicity remains unknown.

271 tal conditions, inoculation at low infection multiplicities resulted in either robust spread, or in l

272 rt a public-domain method for achieving high multiplicity single-cell IF using cyclic immunofluoresce

273 uces tumor lag time and increases incidence, multiplicity, size and progression to malignant squamous

274 ted mice exhibited a large increase in tumor multiplicity, size, and incidence compared with control

275 DSS-induced weight loss and increased tumor multiplicity, size, and invasiveness.

276 vity resulting in a dramatic change in tumor multiplicity, size, morphology and invasiveness.

277 provide the first detailed insight into the multiplicity, structure, and membrane organization of K-

278 versus D75 (30.9%; nominal P = .037, without multiplicity test adjustment).

279 In addition, the collision of end-point multiplicity (the drive to measure multiple end points)

280 uction is higher in cells infected at a high multiplicity, the production of infectious particles is

281 While still limited by conformational multiplicity, this resolution is some 4 times greater th

282 rotein-water fluctuations with quantum-state multiplicity to allow low activation barriers and robust

283 rough electronic manifolds of different spin multiplicity: trans-to-cis isomerization only occurs via

284 eparing two prototype carbenes with distinct multiplicities-triplet pentadiynylidene (HCCCCCH) and si

285 atitis C virus infection and controlling for multiplicity using a false discovery rate threshold of 0

286 was increased 32% in Ahr null mice and tumor multiplicity was approximately increased 3-fold compared

287 Increased tumor multiplicity was not a consequence of CX3CL1-induced met

288 Furthermore, tumor multiplicity was reduced 92% by treatment of I3C in wild

289 mammary tumorigenesis was delayed and tumor multiplicity was reduced by genetic deletion of CX3CL1 i

290 A high degree of genotype multiplicity was seen among T. lestoquardi infections, w

291 derstand the dynamics of GQs with positional multiplicity, we studied five and six repeats human telo

292 Tumor incidence and multiplicity were dramatically smaller in the R group re

293 No adjustments for multiplicity were performed for the prespecified explora

294 Tumor latency and multiplicity were remarkably similar in both immune coho

295 location, septations, and mural nodules and multiplicity, were noted.

296 uce a novel measurement called motif pairing multiplicity which is defined as the number of motifs th

297 tively predict the number of droplet layers (multiplicity), which we used to devise self-assembly rou

298 aches presupposes that we should correct for multiplicity, which is not universally accepted, and the

299 of (.) OH...OP(.) , for which a triplet spin multiplicity with a binding energy of -3.20 kcal mol(-1)

300 ral proteins in MDCK cells infected at a low multiplicity with IAV, we observe that the majority of i