ライフサイエンスコーパス: mural cell

1 formations involving impaired recruitment of mural cells.

2 n macrophages and endothelial cells, but not mural cells.

3 h factor receptor (PDGFR)-beta in associated mural cells.

4 ion in pericytes, without affecting arterial mural cells.

5 activity of individual and small clusters of mural cells.

6 rocytes, fibroblasts, endothelial cells, and mural cells.

7 te its own expression and that of JAGGED1 in mural cells.

8 itors of endothelial cells, blood cells, and mural cells.

9 endothelial cells as well as of perivascular mural cells.

10 ial cell-mural cell interactions and loss of mural cells.

11 expressed by proliferating but not quiescent mural cells.

12 N-cadherin-dependent cell-cell adhesion with mural cells.

13 ial for interactions between endothelial and mural cells.

14 ICC gut pacemakers were shown to be vascular mural cells.

15 developmental relationship between FRCs and mural cells.

16 ells as epicardium-derived cells (EPDCs) and mural cells.

17 n homolog deleted on chromosome 10 (PTEN) in mural cells.

18 l origin, including fibroblasts and vascular mural cells.

19 gions and expressing Pgdfrb can give rise to mural cells.

20 neural activity-evoked calcium transients in mural cells.

21 etworks with perfusable lumens surrounded by mural cells.

22 nflammatory and mitogenic status of resident mural cells.

23 sion were larger and more densely covered by mural cells.

24 in these mice, with abnormal recruitment of mural cells.

25 vascular network concentrically wrapped with mural cells.

26 ly expressing a diphtheria toxin receptor in mural cells.

27 in the retinal venous system and associated mural cells.

28 is and in the recruitment and maintenance of mural cells.

29 he outer vessel layer and differentiate into mural cells.

30 Furthermore, in mural cells, a dominant-negative Mastermind-like1 constr

31 We now demonstrate that mural cell accumulation evident at embryonic day (E) 13.

32 ptional profiles of fibroblasts and vascular mural cells across four murine muscular organs: heart, s

33 Mural cells actively participated during the whole angio

34 nd during neurovascular coupling, defects in mural cell activity, and an abnormal vascular sex-depend

35 n leukocytes, endothelial cells, or arterial mural cells affected the oscillations in a vessel type-s

36 oter resulted in sparse TdTomato labeling of mural cells, allowing for an unambiguous characterizatio

37 of the CNS, we evaluated distinct classes of mural cells along the vascular tree for both structural

38 b enhanced the proliferation of Wnt7b target mural cells, an effect that associated with decreased ex

39 ressed tip cell migration and recruitment of mural cells and adventitial macrophages.

40 capillaries composed of endothelium lacking mural cells and altered sub-endothelial extracellular ma

41 model consisting of endothelial cells (ECs), mural cells and astrocytes.

42 d non-TGFbetaR dependent processes involving mural cells and derived mesenchymal stem cells.

43 irect the differentiation of neural crest to mural cells and establishes a developmentally relevant d

44 ssue, and (3) greater turnover, not loss, of mural cells and extracellular matrix associates with aor

45 te chemoattractant protein-1 (MCP-1) in cyst mural cells and increased excretion of this chemokine in

46 at Notch3 is important for the investment of mural cells and is a critical regulator of developmental

47 dhesive interactions between endothelial and mural cells and its impact on vascular barrier function

48 signaling axis disrupted the association of mural cells and lymphatic vessels, improved lymphatic dr

49 he stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis

50 mal transition (EMT), and differentiate into mural cells and pdgfra(+)hapln1a(+) mesenchymal epicardi

51 In the brain, Il34 was expressed by mural cells and perivascular fibroblasts, and its transg

52 n signatures that demarcate fibroblasts from mural cells and provide molecular signatures for cell su

53 fibroblast, vascular endothelial cell (VEC), mural cell, and macrophage populations: fibroblasts shif

54 we generated gene regulomes for human BECs, mural cells, and other brain cell types and showed that

55 e supported by the fibroblasts, which act as mural cells, and their growth is increased by the presen

56 that suggested based on lineage tracing that mural cells are adipogenic, contrasting with the conclus

57 Mural cells are also recruited by endothelial cells to f

58 Mural cells are central to vascular integrity and functi

59 t memory T cells are increased, and vascular mural cells are characterized by activation of inflammat

60 Mural cells are emerging as multipotent progenitors of p

61 Mural cells are the main source of Lama2, and Wnt/beta-c

62 r smooth muscle cells, collectively known as mural cells, are recruited through PDGFB (platelet-deriv

63 ngle-cell RNA sequencing datasets identified mural cells as the main NPY-responsive cells in adipose

64 Mural cells associated with coronary arteries also expre

65 g to show that caSMCs derive from pericytes, mural cells associated with microvessels, and that these

66 tients with glioblastomas developed vigorous mural cell-associated vascular channels but few endothel

67 d GSDCs gave rise to tumors harboring robust mural cell-associated vascular channels.

68 detected in meningeal fibroblasts, vascular mural cells, astrocytes, motor neurons and to a lesser e

69 nsity, and normalized vessels with increased mural cell attachment.

70 ated GFP(+) cells were further identified as mural cells based on the presence of the specific XLacZ4

71 At a molecular level, mural-cell beta3-integrin loss enhances signaling via FA

72 that the Arf tumor suppressor gene regulates mural cell biology in the hyaloid vascular system (HVS)

73 gene whose expression is robustly induced in mural cells by coculturing with endothelial cells.

74 DGFR-beta is also involved in recruitment of mural cells by neovessels, regulating maturation of the

75 Overall, our data indicate that mural cells can control tumor growth via paracrine signa

76 ascular maturation, mediating formation of a mural cell coat investing infarct neovessels and protect

77 he mature scar, infarct neovessels acquire a mural cell coat that contributes to the stabilization of

78 ributed to infarct angiogenesis by forming a mural cell coat, stabilizing infarct neovessels.

79 g glomerular capillary development, arterial mural cell coating, and lymphatic vessel development, re

80 ontributes to the proangiogenic abilities of mural cells cocultured with endothelial cells.

81 Mural cells colonizing arteries proximal to the body wra

82 These progenitors reside in the mural cell compartment of the adipose vasculature, but n

83 e show that myofibroblast differentiation of mural cells contributes directly to retinal fibrosis.

84 primarily on studies of microvascular flow, mural cell control of vessel diameter, and oxygen level-

85 e (NOS) inhibitor, we found that NO mediates mural cell coverage as well as vessel branching and long

86 use of impaired lymphatic drainage, aberrant mural cell coverage fostered the accumulation of fibroge

87 is both necessary and sufficient to support mural cell coverage in arteries using genetic rescue in

88 ll migration, which likely led to stabilized mural cell coverage of mature vessels.

89 Mural cell coverage of the blood vessels was also reduce

90 NEM inoculation specifically promoted mural cell coverage of tumor vessels and decreased vascu

91 demonstrated RhoA activation induced loss of mural cell coverage on the endothelium and reduced endot

92 lts in severe mucosal hemorrhage, incomplete mural cell coverage on vessel walls, and gastrointestina

93 phatic vessels with reduced and disorganized mural cell coverage.

94 es and promoted vascular growth with reduced mural cell coverage.

95 angiogenesis and vessels exhibited improved mural cell coverage.

96 Defective mural-cell coverage is associated with the poorly organi

97 stem, comprising endothelial cells (ECs) and mural cells, covers a vast surface area in the body, pro

98 1) with a Cre-loxP approach in mice leads to mural cell defects and postnatal lethality.

99 Mouse mural cells demonstrate lower levels of Cd19 expression,

100 brain tissues display a marked reduction in mural cell density as well as abnormal vessel wall morph

101 various cellular responses, but its role in mural cell-dependent vascular stabilization is unknown.

102 In particular, mural-cell-derived CCL2 stimulates tumor cell MEK1-ERK1/

103 te that after chemical ocular injury, Myh11+ mural cells detach from the retinal microvasculature and

104 ons synergistically with TGFbeta to regulate mural cell development and vascular wall stability.

105 ntroduce the signalling pathways controlling mural cell development followed by an overview of mural

106 demonstrate embryonic hemorrhaging, altered mural cell development, or lethality.

107 To explore the cues that regulate mural cell differentiation and homeostasis, we have gene

108 Our findings emphasize that the level of mural cell differentiation and stabilization of the vasc

109 l cells, Cx43-/- progenitors did not undergo mural cell differentiation as did Cx43+/+ cells.

110 e fate-determining significance of NKX3.1 in mural cell differentiation but also highlights the thera

111 ells did produce latent TGF-beta and undergo mural cell differentiation in response to exogenous TGF-

112 own a role for TGF-beta in coculture-induced mural cell differentiation, growth inhibition resulting

113 OTCH3 is necessary for endothelial-dependent mural cell differentiation, whereas overexpression of NO

114 helial cells and undergo endothelial-induced mural cell differentiation.

115 f later stages of vessel assembly, including mural cell differentiation.

116 mediates TGF-beta activation and subsequent mural cell differentiation.

117 ication is necessary for endothelial-induced mural cell differentiation.

118 Mural cells directly contact macrophages in the dural la

119 ansitional segment (TS), which is covered by mural cells distinct from SMCs and pericytes.

120 wed a transient increase in proliferation of mural cells during postnatal maturation.

121 ent required for survival of endothelial and mural cells during vascularization.

122 cyte, granulosa cells, including cumulus and mural cells), during ovarian follicle development in viv

123 Pericytes are vascular mural cells embedded in the basement membrane of blood m

124 Pericytes are vascular mural cells embedded within the basal lamina of blood mi

125 stead, we identify a stromal source of SLIT, mural cells encircling blood vessels, and show that loss

126 pericytes and vascular smooth muscle cells (mural cells) ensures the formation of a mature and stabl

127 population of pericytes, a multi-functional mural cell essential for sensory hair cell heath and nor

128 Pericytes are a unique class of mural cells essential for angiogenesis, maintenance of t

129 was hypermuscularized, with a hyperplasia of mural cells expressing more contractile proteins, wherea

130 hrough VEGFA-laden microparticles and act as mural cells for newly formed vessels, driving scar progr

131 ry caps (BCs), constitutes a major source of mural cells for the developing skin vasculature.

132 s surveillance is enabled by endothelial and mural cells forming the sinus stromal niche.

133 , we observed a rapid physical withdrawal of mural cells from the endothelium that was accompanied by

134 PDGFRbeta-dependent signal transduction and mural cell function.

135 These iMPCs exhibit key mural cell functionalities such as contractility, deposi

136 In this Review, I discuss mural cell functions and their interactions with endothe

137 ther, K2 as an integrin coactivator sustains mural cell functions, contributing to vascular stabiliza

138 tion of dynamically contractile perivascular mural cell - generally, but not universally, recognized

139 sis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and s

140 brain mural cells have low expression of key mural cell genes, including NOTCH3.

141 Here, we show that mural cells have active Wnt/beta-catenin signaling durin

142 Existing in vitro models of human brain mural cells have low expression of key mural cell genes,

143 nt investment of the vascular endothelium by mural cells (i.e., pericytes and vascular smooth muscle

144 le nearly 200,000 endothelial cells (EC) and mural cells, identifying novel subclusters and cell stat

145 f the normal function and pathophysiology of mural cells in a variety of disease models.

146 e characterized calcium dynamics of cortical mural cells in anesthetized or awake Pdgfrb-CreERT2;Rosa

147 servation has overlooked potential roles for mural cells in directly affecting tumor growth independe

148 t in vivo evidence for a functional role for mural cells in patterning and stabilization of the early

149 te the utility of these tools to investigate mural cells in the context of Alzheimer's disease and ce

150 cular coupling is initiated, and the role of mural cells in the control of vasomotility.

151 s on the vascular structures and identity of mural cells in this region that impart the vasomodulator

152 bility of a broad range of investigations of mural cells in vascular development, neurovascular coupl

153 increased the proliferation and migration of mural cells in vitro and improved perivascular cell cove

154 tenin activation induces Lama2 expression in mural cells in vitro.

155 ecise tracing of the lineage contribution of mural cells in vivo than previous versions.

156 e functional and structural heterogeneity of mural cells in vivo, and allow detailed cellular studies

157 e BC population in mice, which gives rise to mural cells, in addition to previously described neurons

158 Perivascular mural cells including vascular smooth cells (VSMCs) and

159 face of blood vessels, and adjacent vascular mural cells, including smooth muscle cells and pericytes

160 ated interplay between endothelial (ECs) and mural cells, including vascular smooth muscle cells (vSM

161 n, concentric layers of still poorly defined mural cells, including vascular smooth muscle cells (VSM

162 The number of endothelial and mural cells increased significantly, and the local tissu

163 th muscle cell-specific alpha-actin-positive mural cells, indicative of maturation.

164 s (NFAT) signaling and APOE in pericyte-like mural cells induces APOE4-associated CAA pathology.

165 talk, much debate remains with regard to how mural cells influence endothelial cell biology and there

166 e capable of generating the fibroblastic and mural cell infrastructure of murine lymph nodes.

167 model revealed that NO mediates endothelial-mural cell interaction prior to vessel perfusion and als

168 athway causes disruption of endothelial cell-mural cell interactions and loss of mural cells.

169 also a key mediator of endothelial-vascular mural cell interactions, a role that may contribute to t

170 lar endothelial cells and the recruitment of mural cells into the cornea.

171 duces differentiation of human brain PDGFRB+ mural cells into VSMCs, and blood flow is required for V

172 deficient mice and led to a higher number of mural cell-invested vessels than control transfection.

173 xamined the emergence and functional role of mural cells investing the dorsal aorta during early deve

174 ll remodelling in association with losses in mural cell investment and disruptions in arterial-venous

175 Angiogenesis, mural cell investment, leukocyte recruitment, vascular p

176 Moreover, Notch3 deletion impairs mural cell investment, resulting in progressive loss of

177 Pericytes are capillary-associated mural cells involved in the maintenance and stability of

178 nication between endothelial cells (ECs) and mural cells is critical in vascular maturation.

179 s by which nascent vessels are invested with mural cells, is important in angiogenesis.

180 mediates coating of developing vessels with mural cells, leading to the formation of a mature vascul

181 RISPR-mediated knockout of N-cadherin in the mural cells led to loss of barrier function, and overexp

182 man bone marrow stromal cells, which adopt a mural cell-like phenotype that recapitulates barrier fun

183 ly in development alongside the emergence of mural cell lineages and persists throughout adulthood ac

184 n emphasis on the distinguishing features of mural cells located on different types of blood vessels.

185 ation of an agonist Notch3 antibody prevents mural cell loss and modifies plasma proteins associated

186 Our study revealed a mechanism by which mural cell-macrophage interactions regulate the traffick

187 ndothelial precursor cell marker (CD133) and mural cell markers (calponin, desmin, and smooth muscle

188 ndent enlargement, ii) altered expression of mural cell markers (eg, down-regulation of NG2 and up-re

189 ellular domain (N3ICD) induced expression of mural cell markers PDGFRbeta, TBX2, FOXS1, KCNJ8, SLC6A1

190 od-perfused vascular channels that coexpress mural cell markers smooth muscle alpha-actin and platele

191 terial, endothelial, venous, angiogenic, and mural cell markers were significantly upregulated in min

192 proliferation, expression of mesenchymal and mural cell markers, and coronary blood vessel formation.

193 , while HMC3 cells only stained positive for mural-cell markers (PDGFRbeta and NG2).

194 ed cardiomyocytes, endothelial, and vascular mural cells matured in vitro for 14 days.

195 that a particular subclass of fibroblast and mural cells may be implicated in the sensory neuron dysf

196 Mural cells (MCs) are essential for blood vessel stabili

197 Mural cells (MCs) consisting of vascular smooth muscle c

198 (CMs), endothelial cells (ECs), and vascular mural cells (MCs) differentiated from hiPSCs.

199 uration and stability require recruitment of mural cells (MCs) to the nascent vessel.

200 Recruitment of mural cells (MCs), namely pericytes and smooth muscle ce

201 rophage niche across vascular beds alongside mural cells (MCs)-pericytes and smooth muscle cells.

202 ng 57,324 endothelial cells (ECs) and 27,703 mural cells (MCs).

203 found a higher number and magnitude of NG2+ mural-cell mediated capillary constrictions in the hippo

204 The role of K2 in mural cell-mediated regulation of vascular barrier funct

205 indicated that Notch3, which is expressed in mural cells, mediates these cell-cell interactions.

206 Impaired mural cell migration, differentiation, partial embryonic

207 ARCL1 secretion from quiescent ECs inhibited mural cell migration, which likely led to stabilized mur

208 Interrogating endothelial-mural cell molecular crosstalk revealed angiotypic and o

209 s have highlighted important distinctions in mural cell morphology, gene expression, and contractile

210 epatocyte growth factor (HGF), a mediator of mural cell motility, was up-regulated by Ang1 stimulatio

211 bition of TGFbetaR attenuates Myh11+ retinal mural cell myofibroblast differentiation, and diminishes

212 frb+ fibroblasts (n = 10) and Pdgfrb+/Cd146+ mural cells (n = 11) further indicate that many of these

213 hich line the vascular lumen, and associated mural cells, namely vascular smooth muscle cells and per

214 of Pdgfrb signalling specifically decreased mural cell numbers at the vascular front.

215 defects with lack of proper investment with mural cells of both large and small vessels.

216 Pericytes are perivascular mural cells of brain capillaries.

217 the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascula

218 l cells of Wnt7b/canonical Wnt signaling are mural cells of periureteric bud capillaries in the nasce

219 detected in pericytes, the multi-functional mural cells of the microvessels that regulate blood flow

220 slower kinetics than similar stimulation of mural cells on upstream pial and precapillary arterioles

221 cell development followed by an overview of mural cell ontogeny with an emphasis on the distinguishi

222 fluid biomarker of BBB-associated capillary mural cell pericyte, soluble platelet-derived growth fac

223 0-V5-His were localized to vessel walls in a mural cell (pericyte) position indicating a possible dir

224 of carcinoma cells and in vessel walls in a mural cell (pericyte) position.

225 Mural cells (pericytes and vascular smooth muscle cells)

226 by loss of alpha5 from Pdgfrb-Cre expressing mural cells (pericytes and vascular smooth muscle cells)

227 s may be related to the presence of vascular mural cells (pericytes or smooth muscle cells).

228 Mesenchymal cells including microvascular mural cells (pericytes) are major progenitors of scar-fo

229 ed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-

230 BM-derived periendothelial vascular mural cells (pericytes) were detected at sites of neovas

231 alphaSMA), and iii) dramatic alterations in mural cell phenotype near the optic nerve head.

232 n of mesodermal progenitor cells to a mature mural cell phenotype through activation of the transform

233 atrix adhesion is a major determinant of the mural cell phenotype.

234 Mechanistically, mural cells physically contacted macrophages in the dura

235 further showed that N-cadherin expression in mural cells plays a key role in barrier function, as CRI

236 tes, which represent a big percentage of the mural cell population in aggressive tumors, increases th

237 -derived NO induces directional migration of mural cell precursors toward endothelial cells.

238 irect the recruitment and differentiation of mural cell precursors.

239 ryonic 10T1/2 cells were used as presumptive mural cell precursors.

240 ells to areas of hypoxia, where perivascular mural cells present stromal-derived factor 1 (CXCL-12) a

241 The resulting N3ICD-derived brain mural cells produced extracellular matrix, self-assemble

242 tly, acta2+ VSMCs differentiate from pdgfrb+ mural cell progenitors after they were recruited to CoW

243 helial plexus lined with NG2(+)/PDGFRbeta(+) mural cell progenitors containing immature pericytes, bu

244 Partially depleting mural cells promoted the trafficking of CNS antigen-spec

245 To further dissect the role of NO in mural cell recruitment and vascular morphogenesis, we pe

246 ate that endothelial cell-derived NO induces mural cell recruitment as well as subsequent morphogenes

247 To elucidate the mechanisms controlling mural cell recruitment during development and tissue reg

248 In the developing vasculature, mural cell recruitment is associated with the functional

249 derived growth factor B (PDGF-B), leading to mural cell recruitment thereby contributing to vascular

250 promoting arteriogenesis, angiogenesis, and mural cell recruitment to immature angiogenic sprouts.

251 Our results implicate aberrant mural cell recruitment to lymphatic vessels in the patho

252 Inhibition of mural cell recruitment to the dorsal aorta through disru

253 Mural cell recruitment to the growing endothelial tube i

254 gnaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain.

255 Brain mural cells regulate development and function of the blo

256 Interestingly, these mural cells remain associated with coronary arteries eve

257 Here we report that mural cells require ephrin-B2, a ligand for Eph receptor

258 othelial cells, including choroidal vascular mural cells, retinal astrocytes, and Muller cells.

259 Other populations, such as Nes+ mural cells, S100B+ Schwann cells, and other non-stromal

260 Mural cells (smooth muscle cells and pericytes) are inte

261 otypic interactions of endothelial cells and mural cells (smooth muscle cells or pericytes) are cruci

262 Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibrobla

263 mplish this, we first tested three inducible mural cell-specific mouse lines using a sensitive Ai14 r

264 icyte morphological changes were assessed in mural cell-specific R26-mTmG reporter mice, in which low

265 However, the mechanistic details of how mural cells stabilize vessels are not fully understood.

266 we show that an ensemble of endothelial and mural cell subtypes tile the brain vasculature during th

267 capable of maturing into diverse functional mural cell subtypes, including smooth muscle cells and p

268 solution intravital imaging of the different mural cell subtypes.

269 ene expression analyses of pdgfrb+ EPDCs and mural cells suggest that they express genes that are imp

270 In contrast, pericytes are stromal mural cells that support microvascular capillaries and s

271 Pericytes are a family of mural cells that wrap around the capillary endothelium a

272 ctivity and increase in RhoA activity in the mural cells themselves upon inflammation.

273 o suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence

274 othelial cells induce the differentiation of mural cells through activation and induction of NOTCH3.

275 , I explore therapeutic strategies involving mural cells to alleviate tissue ischemia and improve vas

276 el perfusion and also induces recruitment of mural cells to angiogenic vessels, vessel branching, and

277 r maturation characterized by the failure of mural cells to migrate around endothelial cells.

278 s integrin-ligand pair block the adhesion of mural cells to proliferating endothelia in vitro and in

279 atenin pathway regulates Lama2 expression in mural cells to promote neurovascular unit and barrier ma

280 eneration, and suggest a limited capacity of mural cells to self-renew or contribute to other cell ty

281 asculature relies on active participation of mural cells to stabilize endothelium and a basal level o

282 strains, only those that marked perivascular mural cells tracked the cold-induced beige lineage.

283 We identify CD19 expression in brain mural cells using single-cell RNA sequencing data and co

284 Mural cells (vascular smooth muscle cells and pericytes)

285 nitors and induce their differentiation into mural cells via contact-dependent transforming growth fa

286 ney is dependent on the kinetics of vascular mural cell (VMC) differentiation.

287 othelial trafficking with pericytes/vascular mural cells (VMC), an interaction crucial to vessel stab

288 ncluding astrocytes, microglia, and vascular mural cells (VMCs).

289 , we did not find evidence that newly formed mural cells were derived from pre-existing cells.

290 The sphincters are encircled by contractile mural cells, which are capable of bidirectional control

291 eural crest migration and the recruitment of mural cells, which are essential for vascular stability.

292 atial coordination of endothelial cells with mural cells, which delivers oxygen and nutrients.

293 Loss of mural cells, which encompass pericytes and vascular smoo

294 Here, we demonstrated that mural cells, which include pericytes and smooth muscle c

295 Here, we report that mural cells, which surround the endothelium and are crit

296 st could direct the differentiation of brain mural cells with an improved transcriptional profile.

297 that capillary pericytes are a population of mural cells with distinct morphological, molecular and f

298 mechanistic insights into the cooperation of mural cells with endothelial cells induced by YKL-40 dur

299 purify prenatal human brain endothelial and mural cells with FACS and utilize them in downstream app

300 d enhanced visualization of rods, cones, and mural cells with over an order-of-magnitude improvement