ライフサイエンスコーパス: murine

1 -6 in the regulation of lung inflammation in murine AA caused by Aspergillus fumigatus as well as its

2 In both zebrafish tail injury and murine acute lung injury models of neutrophilic inflamma

3 experimental measurements carried out after murine aerosol infection with the virulent SCHU S4 strai

4 ic analysis revealed that alpha6 deletion in murine ALL was associated with changes in Src signaling,

5 own coloboma genes, along with a comparative murine analysis.

6 against rat and human nNOS, human eNOS, and murine and (in some cases) human iNOS.

7 insulin secretion from single and groups of murine and human islets.

8 L1 loss significantly impairs propagation of murine and human MLL-rearranged leukemia in vitro and in

9 ferentiation capacity of already-established murine and human PSCs.

10 However, NaCl was coopted to promote murine and human Th17 cell pathogenicity, if T cell stim

11 In both murine and human tumor cells, HOTAIR-sbid impaired the a

12 Its involvement in murine and human type 1 diabetes has recently been recog

13 The metabolism of healthy murine and more recently human immune cells has been inv

14 inhibitory concentration, 8 nM [human]/2 nM [murine]) and can be obtained from the parent chelator th

15 ibe in vivo conditional knockout analyses of murine Ars2, which has mostly been studied as a general

16 alleviated arthritis in an LTB(4)-dependent murine arthritis model.

17 ine restriction improves outcome in multiple murine arthritis models and its removal induces preosteo

18 of B cells in a house dust mite (HDM)-based murine asthma model.

19 because genetic activation of HIF-1alpha in murine B cells led to reduced repertoire diversity, decr

20 In vitro effects of MWF exposure on murine B cells were assessed.Measurements and Main Resul

21 Exposure to used MWF stimulated murine B-cell proliferation in vitro, a hallmark cell su

22 on of up to 3 mM tricine does not affect the murine b-wave in both genotypes, most likely because of

23 Antibodies targeted the murine BBB after intravenous administration with one par

24 trating that the analogous ATF4 motif at the murine Bcl11a enhancer is largely dispensable.

25 sted previously by our group, which contains murine binding domains and is used in axicabtagene cilol

26 In the murine bleomycin-induced lung fibrosis model, GSK3008348

27 membranes on in vitro osteoclastogenesis in murine bone marrow cultures.

28 activation on both RAW264.7 macrophages and murine bone marrow-derived dendritic cells; we now show

29 nscriptome and Ingenuity Pathway Analysis of murine bone marrow-derived macrophages after exposure to

30 le of TRIM21 upon S Typhimurium infection of murine bone marrow-derived macrophages.

31 lux, were measured after IgE crosslinking in murine bone marrow-derived mast cells and human cord blo

32 A benchmark test based on the murine brain samples revealed a highly improved annotati

33 mensional, optical imaging technique for the murine brain was developed to identify the effects of di

34 ty and inhibit migration and invasion of 4T1 murine breast cancer cells in vitro.

35 We have employed varying EMT models of murine breast cancer cells to identify the key players e

36 Murine BSM strips overexpressing desmin or vimentin gene

37 carbachol relative to the levels in control murine BSM strips, an effect associated with increased J

38 We employed a model of murine BSM tissue in which increased expression of desmi

39 Here, we used several murine cancer models to test the antitumor efficacy of u

40 antigens recognized by T cells in human and murine cancers.

41 ibroblasts (CAFs) in the microenvironment of murine carcinomas, each endowed with unique phenotypic f

42 l function and structure was assessed in HL1 murine cardiomyocytes and human induced pluripotent stem

43 ogrammed death-ligand 1 (PD-L1) in human and murine CCA.

44 LukGH binds murine CD11b-I weakly and is inactive toward murine neut

45 ouse strains and identified polymorphisms in murine CD300LF which are critical for its function as an

46 l sequencing revealed that in the absence of murine CD4 T cells, resident microglia remained suspende

47 erefore, here we sought to determine whether murine CD8alphaalpha binds only to tissue-specific MHC-I

48 mily furnishes multiple binding partners for murine CD8alphaalpha, including H2-T22 and the CD94/NKG2

49 to disrupt the Pdgfra gene in two different murine cell lines, we show that in addition to the widel

50 (bMFA) to determine whether the response of murine cells to inflammatory activation or anti-inflamma

51 te, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures rese

52 beling staining, and immunohistochemistry in murine cells, tissues, or retinal organotypic cultures,

53 In murine cells, we show that Ifit1b can modulate host tran

54 ffects cell-autonomous immunity in human and murine cells.

55 agocytic uptake into primary or immortalized murine cells.

56 In the present work, using human and murine cells; immunoprecipitation, pulldown, and surface

57 Immortalized murine cementoblasts were exposed to various concentrati

58 -induced ATP release using HEK-293 cells and murine cerebellar granule neurons, along with biolumines

59 A murine Chlamydia readily spreads from the mouse genital

60 n distinct cell types that are infected with murine CMV (MCMV).

61 ate decisions made during the acute phase of murine CMV infection can alter the level of memory infla

62 hase 2 (Nos2) are susceptible to the related murine CMV infection.

63 ng, and demonstrates generalizability across murine cohorts with pancreatic disease.

64 ty was demonstrated in cellular assays and a murine colitis model expressing hPXR by a significant re

65 nvasion gene expression by Salmonella in the murine colitis model, indicating that the HilD-dependent

66 eered a DUB mutation (Asp1772 to Ala) into a murine coronavirus and evaluated the replication and pat

67 imes following infection with a neuroadapted murine coronavirus using scRNAseq.

68 in immune cells were highly susceptible to a murine CoV-mouse hepatitis virus.

69 tallized it with the receptor, and confirmed murine cross-reactivity.

70 Finally, we show that LukE targets murine Darc through DR1 in vivo to cause host lethality.

71 a KC intrinsic mechanism, as suggested from murine data and clinical outcome after topical antipsori

72 The absence of one single murine dermal cell type, the innate neonatal-derived IL-

73 racterize the progenitors of PLV-LMCs during murine development, towards rational therapies that targ

74 The murine digit has been used to study mammalian regenerati

75 ned kidney tissue from healthy mice and five murine disease models and from other species used in pre

76 model of DMD carriers via injection of mdx (murine DMD) embryonic stem cells (ESCs) into wild-type (

77 this phenotype is partially recapitulated in murine Dnmt3a (-/-) bone marrow cells.

78 between human and preclinical species (e.g. murine, dog, macaque) in both biochemical and cellular a

79 An in vivo murine drug release showed a photoacoustic signal enhanc

80 The sex-specific role of murine Dusp8 in governing hypothalamic Jnk signaling, in

81 Moreover, TFs associated with murine EGA are not enriched in cattle or humans, indicat

82 itors give rise to NK cells that, similar to murine EMP-derived NK cells, harbor a potent cytotoxic d

83 Theiler's murine encephalomyelitis virus (TMEV) infection of the C

84 age conversion in TGFbeta1-exposed human and murine endothelial cells and improved venous thrombus re

85 CTEPH-endothelial cells and murine endothelial cells lacking TGFbetaRII simultaneous

86 immunodeficient mice, physiologic levels of murine Epo were sufficient to preferentially expand EpoR

87 ts, we propose a model of TFR2's function in murine erythropoiesis, indicating that deficiency in thi

88 E491/S527, located on opposite sides of the murine Esco2 active site cleft, are critical for catalys

89 e paradigm established by numerous human and murine examples of ISG hyperactivation, including consti

90 n the effect of the human ILT3.Fc protein in murine experimental models of autoimmunity and cancer.

91 -to-hetero transplantation, we established a murine experimental system in which MHC-matched but mino

92 we exploited the hyaloid vascular network in murine eyes, which naturally undergoes regression after

93 yogels showed negligible cytotoxicity toward murine fibroblasts and prevented activation of primary b

94 y of genes encoding STING or cGAS in NIH/3T3 murine fibroblasts and the infection of HEK293 and HEK29

95 , and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes.

96 In murine fibroblasts, GRA15-mediated TRAF6 recruitment med

97 e intra-population to the interspecific, the murine first upper molar shows repeated anterior elongat

98 lly the effects of statin therapy on primary murine fistula patency and maturation.

99 pulations, we studied outcome signals in the murine forelimb M1.

100 ndidates based on the evidence obtained from murine functional studies and human single-cell (sc)RNA-

101 gonism, we previously developed a mouse anti-murine GIPR antibody (muGIPR-Ab) that protected diet-ind

102 apeutic reduction of intraocular pressure in murine glaucoma models.

103 hat uses FUS to increase BBB permeability in murine glioblastoma models and thus enhance the release

104 kade extends survival in clinically relevant murine glioma models and provides the basis on which to

105 Murine HCC cell lines were generated from each tumor mod

106 This novel collection of murine HCC models and corresponding cell lines establish

107 ptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-tar

108 e identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to

109 uenza virus hemagglutinin and in variants of murine hepatitis virus, a coronavirus.

110 that ROS impaired interferon response during murine herpesvirus infection and that the inhibition occ

111 tau secretion by VAMP8 was also observed in murine hippocampal slices.

112 thin the chicken Chd7 gene and its human and murine homologs, and we show that let-7g overexpression

113 ACV glycoprotein precursor complex (GPC) and murine hybridoma technology to generate 25 mouse monoclo

114 We next investigated how EPA improved murine hyperinsulinemia and hyperglycemia.

115 ics of brown adipocytes, we propose that the murine iBAT has two different growth phases between birt

116 Here we use single cell RNA-seq to show that murine IFE differentiation is best described as a single

117 odulates the expression of genes involved in murine immune cell chemotaxis.

118 of the autophagy-inflammasome axis in innate murine immune cells.

119 The identified murine immune escape signature was reflected in human pa

120 Murine-induced, Itpkb-deleted (Itpkb-/-) T cells attenua

121 d Mtb clearance in macrophages as well as in murine infection model, suggesting its utility for host

122 d potent efficacy in an in vivo tuberculosis murine infection model.

123 y of the mutant was severely attenuated in a murine infection model.

124 Using murine infection with lymphocytic choriomeningitis virus

125 ritis (RA), we evaluated the role of PON1 in murine inflammatory arthritis.

126 Nevertheless, studies of a murine iron-refractory iron-deficiency anemia-causing mu

127 was demonstrated, because the equivalents in murine ISG15 of 2 aa recently implicated in binding of h

128 Here we used an allogeneic murine islet transplantation tolerance model to examine

129 , possibly, compromised in laforin-deficient murine LD.

130 row-derived cells validated the results in a murine Leishmania ear infection model.

131 It is not known if murine leukemia virus (MLV) encodes a Vif-like protein.

132 y the glycosylated Gag (glycoGag) protein of murine leukemia virus (MLV), the S2 protein of equine in

133 Based on previous studies of murine leukemia virus and HIV-1, we hypothesized that un

134 P1 is universally silenced in both human and murine liver tumours.

135 eq to investigate the protease repertoire of murine lower airway tissues, primary type II alveolar ep

136 Review of murine lung tissue confirmed a diagnosis of adenoma and

137 including immune-epithelial PICs in neonatal murine lungs.

138 l localizations in different compartments of murine lungs.

139 IFN-lambda protein is increased in murine lupus and IFN-lambda receptor (Ifnlr1) deficiency

140 The murine macrophage cell line RAW 264.7 was three-dimensio

141 ation profiles are different among polarized murine macrophage subsets.

142 for IFN-gamma-dependent anti-MNV activity in murine macrophages.

143 us (MNV) infection induce GBP2 expression in murine macrophages.

144 pfii GT-II (but not GT-I) invaded bovine and murine mammary epithelial cells (MECs) and induced apopt

145 In a murine mammary infection model, P. zopfii GT-II replicat

146 nt for the differentiation and activation of murine mast cells and for the manifestations of food all

147 ition of CAV1 immunoprecipitates from B16F10 murine melanoma cells expressing or not E-cadherin.

148 This study utilized a murine melanoma model to evaluate the efficacy of intrat

149 vitro as well as flow-induced dilatation in murine mesenteric arteries.

150 bilateral tumor implantation technique in a murine metastatic breast cancer model (E0771) coupled wi

151 nstants of binding to the well-characterized murine MHC allele H-2D(b) are known, by applying thresho

152 e genetically ablated it in an autochthonous murine model (KrasG12D; Pdx-1cre, KC), which mirrors the

153 nologic PET imaging of multiple myeloma in a murine model and in humans.

154 ized the HLH-like syndromes occurring in the murine model and in humans.

155 In vivo studies using a murine model displayed that the recombinant Asp t 36 was

156 abetic full-thickness splinted wound healing murine model enhanced the microcirculatory blood flow an

157 rated that genome-wide expression in our new murine model more closely approximated human surgical se

158 ix remodeling and inflammatory activity in a murine model of AAA.

159 lly relevant unilateral ischemia-reperfusion murine model of AKI at days 1, 2, 4, 7, 11, and 14 after

160 desis and bronchial hyperresponsiveness in a murine model of allergic lung inflammation.

161 In a murine model of AML, dual treatment with MTP-PE and IFN-

162 In summary, we describe a murine model of broad and immediate utility to investiga

163 A novel, rapidly progressing, severe, murine model of C3G was developed by replacing the mouse

164 rmed in vivo with an angiotensin II-mediated murine model of cardiac fibrosis in both preventive and

165 In a murine model of CCA, recruited PD-L1+ TAMs facilitated C

166 ity in a dose-dependent manner in vitro In a murine model of CDI, exogenous administration of ursodio

167 provide long-term modulation of allergy in a murine model of cow's milk allergy.

168 Using a murine model of elastase-induced emphysema we demonstrat

169 Here, we employ a sensitized murine model of islet transplantation to test strategies

170 and to examine its safety and efficacy in a murine model of lethal HSV-2 infection.

171 sine-modified fibronectin was increased in a murine model of lung fibrosis and in human subjects with

172 mental autoimmune encephalomyelitis (EAE), a murine model of MS, adoptive transfer of IL-10(+) regula

173 64D), and a spontaneous transgenic (TH-MYCN) murine model of neuroblastoma, comparing histological fe

174 Using a murine model of nHSV, we demonstrated that maternal immu

175 Using a murine model of osteomyelitis, we examined survival of S

176 In a hypomorphic murine model of PA, dual mRNAs normalize ammonia similar

177 Thus, a murine model of perforin-deficient CAR T cells recapitul

178 ly, DeltamumR exhibited reduced fitness in a murine model of pneumonia, indicating that MumR-regulate

179 In a murine model of polymicrobial infection (cecal ligature

180 ting TLR7-induced pathology in a preclinical murine model of psoriasis.

181 Also, we found that during a murine model of sepsis, P2X7 receptor activity is import

182 the survival of the mottled-brindled mouse-a murine model of severe Menkes disease.

183 duced pancreatitis, and in an oncogenic Kras murine model of spontaneous pancreatic ductal adenocarci

184 In a murine model of sterile kidney injury, reduced neutrophi

185 Using a murine model of systemic infection, we observed tcyP-dep

186 ests and synaptic plasticity phenotypes in a murine model of the disease.

187 at the CRISPR-Cas9 generated Gaa(c.1826dupA) murine model recapitulates hypertrophic cardiomyopathy a

188 Moreover, a murine model reveals that Fe(3+) crosslinked foam displa

189 When applied to a murine model these proinsulin-coated MNs efficiently pun

190 xia-associated IUGR, we used an experimental murine model to determine whether such effects may be at

191 In a murine model, Alp1 elicits helper T (Th) cell-dependent

192 ient (ApoE(-/-)) atherosclerosis progression murine model, T1317-sHDL showed superior inhibition of a

193 tudy provided the first evidence that in the murine model, the serum level and anaphylactic activity

194 raft pancreatic cancer (BxPC-3) tumours in a murine model.

195 late the pathogenesis of Chagas disease in a murine model.

196 ion, and T-cell cross-reactivity in a BALB/c murine model.

197 scular inflammation and atherosclerosis in a murine model.

198 linically relevant S. aureus wound infection murine model.

199 icacy and HLH-like toxicities in a syngeneic murine model.

200 gainst a lethal dose of HSV-2 infection in a murine model.

201 Murine modeling shows that neurogenesis is likely altere

202 s has been extensively studied using in vivo murine models and cell lines, typically challenged with

203 Evidence from murine models and human post-mortem studies indicates th

204 chia coli can inhibit autoimmune diseases in murine models by inducing bystander tolerance.

205 a suggest that GL261 Red-FLuc and GL261-Luc2 murine models elicit an anti-tumor immune response by in

206 eveal that excessive placental DNA damage in murine models for Cornelia de Lange syndrome results in

207 view insights obtained from experiments with murine models of allergic airway and skin inflammation a

208 Using murine models of both perinatal and postnatal GBS acquis

209 p in Tie2 expression observed across various murine models of critical illnesses is associated with i

210 ma-globin and illustrate potential limits of murine models of globin gene regulation.

211 lopment of NC mice, we employed two distinct murine models of iNKT cell over-representation: Vbeta8 T

212 s), which is a cell population implicated in murine models of pulmonary fibrosis.

213 h, and discuss emerging methods for creating murine models that better reflect the genetic basis of t

214 s of lncRNAs have been revealed primarily in murine models with limited understanding of lncRNAs in h

215 In murine models, CX-6258 induced a potent cGAS-dependent t

216 , which is in line with previous findings in murine models.

217 for preclinical research in immunocompetent murine models.

218 Murine muscle stem cells (MuSCs) experience a transition

219 oblasts and vascular mural cells across four murine muscular organs: heart, skeletal muscle, intestin

220 in signaling skewed the profile of human and murine MVPC toward an adaptive phenotype.

221 oliferation, cell death, or UPR induction in murine myeloblast 32D and human promyelocytic NB4 cells.

222 k, which was downregulated in both human and murine myeloid cells exposed to LPS as well as other TLR

223 to the ability to successfully colonise the murine nasopharynx.

224 ffects of deregulating MYC expression in the murine NeuNT model of amplified-HER2 breast cancer.

225 hagocytosis/killing by an oxidative burst of murine neutrophils in vitro Intravital microscopy (IVM)

226 (2)) and were linked to LTB(4) production in murine neutrophils.

227 murine CD11b-I weakly and is inactive toward murine neutrophils.

228 lelic mutations has ever been described, and murine Nmnat1 knockouts show embryonic lethality, indica

229 e absence of a functional GM-CSF receptor in murine nociceptors, and suggest an indirect mechanism of

230 In this study, the inactivation kinetics of murine norovirus (MNV) by PFA, in phosphate buffer and m

231 we show that both IFN-gamma stimulation and murine norovirus (MNV) infection induce GBP2 expression

232 gamma-secretase processing of human APP, the murine Notch derivative mNDeltaE and human neuregulin-1.

233 ause of chelating amino acids present in the murine nutrient solution.

234 eal administration of this vector delivering murine or human proSFTPB cDNA into SP-B deficient mice r

235 These findings exploit murine organoid models to uncover the mechanism of ERG-m

236 were performed using human cell lines and a murine organoid system.

237 d now allow to image and quantify the entire murine organs with cellular resolution.

238 We utilized an optimized orthotopic murine osteosarcoma model and human osteosarcoma cells i

239 Moreover, depletion of pDCs in the murine OX40+ pDC-rich tumor model accelerated tumor grow

240 w SRSF7 maintains its protein homeostasis in murine P19 cells using an intricate negative feedback me

241 ning the 3-dimensional (3D) structure in the murine PDL.

242 e characterized the inflammatory response in murine peritonitis and unexpectedly found the accumulati

243 r mapping biotin transporter activity in the murine placenta.

244 PE, in calcium ionophore (A23187)-stimulated murine platelets.

245 d neonatal mice were inoculated with RSV and murine Pneumovirus, respectively.

246 s of different phenotypes in a population of murine prostate cancer cells, and describes the hysteres

247 Genome-wide mapping of epidermal 5-hmC in murine psoriasis revealed loci-specific loss of 5-hmC in

248 Murine RAW 264.7 macrophages were incubated with sterile

249 es (i.e., chicken thigh muscle with skin and murine renal biopsy including medulla (M) and cortex (C)

250 -Kit(+) ICs are a minor population of ICs in murine renal pelvis.

251 of transretinal signaling only occurs in the murine retina from Ca(v)2.3 competent mice, supporting t

252 ntify such candidates, we used the laminated murine retina to screen 92 lacZ reporter lines available

253 single-cell RNA sequencing were used in the murine, reversible, unilateral ureteric obstruction mode

254 Inhibition of UA or IL-1beta during neonatal murine RSV infection decreased mucus production, reduced

255 rrent methods have supported the recovery of murine RV, impeding the study of RV replication and path

256 Molecular analyses of human and murine samples define microenvironmental consequences of

257 ion and deletion variants for both human and murine samples using ChIP-Seq data.

258 hough heterogeneity is recognized within the murine satellite cell pool, a comprehensive understandin

259 t the cryo-electron microscopy structures of murine SIgA and dIgA.

260 altered mitochondrial coupling efficiency in murine skeletal muscle, and expression of UCP3, AAC1, or

261 rturb TJs in human lung as well as human and murine skin epithelium, enabling epicutaneous vaccine de

262 arger lesions than the wild type (WT) during murine skin infection.

263 erate a model that expresses a mutant of the murine Sod1 gene ubiquitously, a condition sufficient to

264 Here, using structure guided design of the murine STING CDN binding domain, we engineer a Forster r

265 epetitive ozone exposures are exacerbated in murine strains that are hyperglycemic and insulin resist

266 In both of these murine strains, immunization with our modified protocols

267 Importantly, recent murine studies have provided substantial insights into P

268 term MI experiments along with complementary murine studies revealed myocardial protection, improved

269 antibiotic tolerance in the spleen during a murine systemic infection.

270 cells, and opioids attenuate inflammation in murine T cell-mediated autoimmunity models.

271 In vitro, murine T cells were stimulated in the presence of liragl

272 ify c-Maf as a crucial negative regulator of murine T-bet(+) CCR6(-) ILC3s.

273 f the blood-brain barrier (BBB), 12 mo after murine TBI, is associated with arrested axonal neurodege

274 ific and ubiquitous small RNAs in individual murine tissues to date, and we expect that these data wi

275 antial survival benefit in highly metastatic murine TNBC models poorly responsive to PD-1 blockade.

276 also enhanced ADR or cisplatin inhibition of murine TNBC tumors in vivo and reduced systemic levels o

277 posttransplant alloantibody production in a murine transplant model.

278 ficient to induce CMV reactivation following murine transplantation of a latently infected graft.

279 Deletion of murine Trim9 or Trim67 results in neuroanatomical defect

280 Using murine tumor allograft models, we show that systemic or

281 study, we examined Amiodarone's effects on a murine tumor model comprised of U-87 MG glioblastoma mul

282 ith the formation of immunological memory in murine tumor models and robust activation of human APCs.

283 rize tumor-specific CD8+ and CD4+ T cells in murine tumor models.

284 Macrophages from both human and murine tumor tissues were enriched with lipids due to in

285 retention in a subcutaneous flank colorectal murine tumor, and therapeutic response characterized by

286 In murine tumors, a large proportion of CD8(+) TILs had dec

287 ironment following fractionated radiation in murine tumours consistent with clinical reports.

288 e compared two splicing variants (V1, V2) of murine UHRF1 (mUHRF1) with human UHRF1 (hUHRF1).

289 s a high affinity for both the human and the murine variants of the CXCR4 receptor (half-maximal inhi

290 ormoxic (LOX) human melanoma xenografts in a murine window chamber model.

291 ion (IVF), pharmacological activation of the murine X chromosome-encoded receptor proteins Toll-like

292 effective at impairing tumor development in murine xenogeneic model, activating the innate immune re

293 Biophysical, cell-based, and murine xenograft experiments demonstrate that a syntheti

294 A murine xenograft model using CD38-positive OPM2 multiple

295 Results from experiments with murine xenografts and 2D and 3D co-cultures of NHFs and

296 prodrug of the PARP inhibitor talazoparib in murine xenografts provides tumor suppression equivalent

297 In patient-derived monosomal karyotype AML murine xenografts, decitabine treatment resulted in supe

298 ic stem cells lacking one or both of the two murine Y RNAs.

299 ro-myeloid progenitors (EMPs) present in the murine yolk sac.

300 The murine Zscan4 is involved in telomere maintenance and ge