ライフサイエンスコーパス: murine cytomegalovirus

1 plify both inflammasome and IFN-I to control murine cytomegalovirus.

2 rpesvirus 1, guinea pig cytomegalovirus, and murine cytomegalovirus.

3 of retinitis after supraciliary injection of murine cytomegalovirus.

4 not DR3 dependent after viral challenge with murine cytomegalovirus.

5 emerged as a host defence mechanism against murine cytomegalovirus.

6 rom herpes simplex virus type 1 and M48 from murine cytomegalovirus.

7 also blocked duplication and deletion of the murine cytomegalovirus 30-bp terminal repeat at the ecto

8 Here we describe a murine cytomegalovirus 7.2-kb ortholog of the human cyto

9 Murine cytomegalovirus (9 x 10(2) plaque forming units [

10 For murine cytomegalovirus and Epstein-Barr virus, chosen as

11 previous proposals for mutations in UL104 of murine cytomegalovirus and HCMV strains resistant to BAY

12 e showed hypersusceptibility to infection by murine cytomegalovirus and multiple defects of lymphoid

13 xplain the absence of such tRNA densities in murine cytomegalovirus and other human herpesviruses.

14 55 "Lambda"-shaped dimeric CATCs observed in murine cytomegalovirus and the 310 "Delta"-shaped CATCs

15 also induced acute allograft rejection, but murine cytomegalovirus and vaccinia virus (VV) did not.

16 to five heterologous viruses (LCMV, PV, VV, murine cytomegalovirus, and vesicular stomatitis virus)

17 is a site of persistence for both human and murine cytomegaloviruses, and salivary secretions appear

18 h differential effects of NK subsets on anti-murine cytomegalovirus (anti-MCMV) responses after synge

19 as been modeled in BALB/c mice infected with murine cytomegalovirus by the supraciliary route.

20 Murine cytomegalovirus carries a CC (beta) chemokine hom

21 Latent infection with murine cytomegalovirus causes TF cytoplasmic domain-depe

22 The murine cytomegalovirus CC chemokine homolog MCK-2 (m131-

23 oduction is critical for host defense during murine cytomegalovirus challenge.

24 og gene giving rise to two related proteins, murine cytomegalovirus chemokine 1 and 2 (MCK-1 and MCK-

25 Murine cytomegalovirus (CMV) and herpes simplex virus (H

26 ted mice after supraciliary inoculation with murine cytomegalovirus compared with less intense DNA la

27 (d)/Fc gamma1 molecules were loaded with the murine cytomegalovirus-derived peptide and other L(d)-sp

28 s the most effective agent against human and murine cytomegalovirus (EC(50) 0.25-1.1 microM).

29 Systemic infection with murine cytomegalovirus elicited a significant increase i

30 Here, we report that the murine cytomegalovirus-encoded CC chemokine, MCK2, enhan

31 Murine cytomegalovirus encodes a secreted, pro-inflammat

32 The M78 protein of murine cytomegalovirus exhibits sequence features of a G

33 Murine cytomegalovirus expresses a 7.2-kb-long noncoding

34 rapid phenotypic screening, we identified a murine cytomegalovirus gene governing endothelial cell t

35 by inserting ectopic cleavage sites into the murine cytomegalovirus genome and assessing their abilit

36 e ectopic cleavage sites engineered into the murine cytomegalovirus genome mediated formation of pac2

37 Within the murine cytomegalovirus genome, m41, m40, and m39 form a

38 iased approach to identify such genes in the murine cytomegalovirus genome.

39 olog of vMIA, m38.5, which was identified in murine cytomegalovirus, has been shown to localize to mi

40 5b was the most effective against human and murine cytomegalovirus (HCMV and MCMV) with EC(50) = 0.2

41 lar or submicromolar range against human and murine cytomegalovirus (HCMV and MCMV), Epstein-Barr vir

42 Both human and murine cytomegaloviruses (HCMV and MCMV) down-regulate e

43 the recently published NMR structure of the murine cytomegalovirus homolog pM50 but reveals a consid

44 ine gammaherpesvirus 68) or betaherpesvirus (murine cytomegalovirus), HS is rapidly upregulated at th

45 49H, is critically involved in resistance to murine cytomegalovirus in vivo.

46 In transfected and murine cytomegalovirus-infected cells, m02, m04, m05, m0

47 cells protects mice from retinitis caused by murine cytomegalovirus infection after supraciliary inoc

48 cells (DC), and natural killer (NK) cells to murine cytomegalovirus infection and found distinct func

49 l responses and plasma cell expansion during murine cytomegalovirus infection and modestly restrains

50 pattern of regulation was found in vivo with murine cytomegalovirus infection as a physiologic model

51 In mice, systemic murine cytomegalovirus infection decreased serum erythro

52 Here, we investigate the consequences of murine cytomegalovirus infection in newborn mice on NK c

53 ed at the transcriptional level during acute murine cytomegalovirus infection or after repetitive pol

54 production by activated NK cells in an acute murine cytomegalovirus infection was significantly reduc

55 effect on interferon gamma production during murine cytomegalovirus infection, stimulating it in conv

56 that in the setting of a short-term (4-day) murine cytomegalovirus infection, terminally differentia

57 In response to murine cytomegalovirus infection, we show that circulati

58 display long-term, memory-like responses to murine cytomegalovirus infection.

59 e spleen and liver at homeostasis and during murine cytomegalovirus infection.

60 phase of viral-induced proliferation during murine cytomegalovirus infection.

61 premature death of endothelial cells during murine cytomegalovirus infection.

62 l, which coincided with host survival during murine cytomegalovirus infection.

63 Lymphocytic choriomeningitis virus and murine cytomegalovirus infections also induced this traf

64 During murine cytomegalovirus infections known to target spleen

65 induced liver pathology was evaluated during murine cytomegalovirus infections of mice.

66 during lymphocytic choriomeningitis virus or murine cytomegalovirus infections resulted in profound s

67 The m144 glycoprotein, expressed by murine cytomegalovirus, is thought to be an MHC-I homolo

68 ronic infection of Zbtb32(-/-) chimeras with murine cytomegalovirus led to nearly 20-fold higher anti

69 The murine cytomegalovirus m02 gene family encodes putative

70 Murine cytomegalovirus m38.5, whose position in the vira

71 The murine cytomegalovirus m41 product is the first example

72 The murine cytomegalovirus M45 protein interacts with recept

73 structure of the cysteine protease domain of murine cytomegalovirus M48 (M48(USP)) in a complex with

74 tTS(Kid) repressor under the control of the murine cytomegalovirus (mCMV) (HC-Ad-mTetON-beta-Gal) or

75 d without cGvHD received a nonlethal dose of murine cytomegalovirus (MCMV) +100 days after transplant

76 Three proteins encoded by murine cytomegalovirus (MCMV) -- gp34, encoded by m04 (m

77 Animals were infected with murine cytomegalovirus (MCMV) after birth at 2 days (P2)

78 toxic trNK cells during local infection with murine cytomegalovirus (MCMV) and contributed to viral c

79 Murine cytomegalovirus (MCMV) and human CMV (HCMV) share

80 e response to viral infections, particularly murine cytomegalovirus (MCMV) and human herpesviruses.

81 his report, we studied the interplay between murine cytomegalovirus (MCMV) and human monocyte-derived

82 tions with two different persistent viruses, murine cytomegalovirus (MCMV) and lymphocytic choriomeni

83 were examined in C57BL/6 mice infected with murine cytomegalovirus (MCMV) and other viruses, includi

84 ) as major producers of the cytokines during murine cytomegalovirus (MCMV) but not lymphocytic chorio

85 ell- depleted BALB/c mice were injected with murine cytomegalovirus (MCMV) by supraciliary injection.

86 Here, we defined the genetic stability of murine cytomegalovirus (MCMV) by whole-genome sequencing

87 to target the overlapping mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential

88 FasL-deficient B6-gld/gld mice infected with murine cytomegalovirus (MCMV) cleared the virus from the

89 mRNA of the late kinetic class expressed by murine cytomegalovirus (MCMV) contains an open reading f

90 e that endothelial cells are a major site of murine cytomegalovirus (MCMV) DNA in latently infected a

91 A gene (HJ1) present in murine cytomegalovirus (MCMV) encodes an open reading fr

92 o evade detection by the host immune system, murine cytomegalovirus (MCMV) encodes three proteins tha

93 By contrast, systemic infection with a murine cytomegalovirus (MCMV) engineered to express HEL

94 xpressed endogenously during infections with murine cytomegalovirus (MCMV) enhanced early IL-12 and I

95 We used recombinant murine cytomegalovirus (mCMV) expressing either green fl

96 mechanisms that permit prolonged shedding of murine cytomegalovirus (MCMV) from the salivary gland, t

97 Murine cytomegalovirus (MCMV) gene products dispensable

98 a pool of 13 plasmid DNAs (pDNAs) expressing murine cytomegalovirus (MCMV) genes followed by formalin

99 ice with plasmid DNAs (pDNAs) expressing the murine cytomegalovirus (MCMV) genes IE1-pp89 and M84 pro

100 deficient adenoviruses expressing individual murine cytomegalovirus (MCMV) genes protected mice again

101 he species specificity of cytomegaloviruses, murine cytomegalovirus (MCMV) has been used as a model f

102 rpesviruses human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) have also separately evolv

103 vaccination of BALB/c mice with DNA encoding murine cytomegalovirus (MCMV) IE1 or M84, a similar leve

104 oxic T-lymphocyte (CTL) response against the murine cytomegalovirus (MCMV) immediate-early gene 1 (IE

105 The murine cytomegalovirus (MCMV) immediate-early gene 1 (IE

106 at in vitro stimulation of spleen cells from murine cytomegalovirus (MCMV) immune mice with MCMV-infe

107 Efficient replication of murine cytomegalovirus (MCMV) in macrophages is a prereq

108 Astrocytes are the first cells infected by murine cytomegalovirus (MCMV) in primary cultures of bra

109 tion of apolipoprotein E-deficient mice with murine cytomegalovirus (MCMV) increases serum levels of

110 Early infection with murine cytomegalovirus (MCMV) induces circulating levels

111 Infection of mouse cells with murine cytomegalovirus (MCMV) induces the rapid down-reg

112 this study was to determine whether systemic murine cytomegalovirus (MCMV) infection acquired early i

113 for innate regulation of the acute phase of murine cytomegalovirus (MCMV) infection and have been re

114 Murine cytomegalovirus (MCMV) infection and the TLR3 lig

115 e model was used to determine the pattern of murine cytomegalovirus (MCMV) infection and whether apop

116 plantation, 3 x 10(3) CLPs protected against murine cytomegalovirus (MCMV) infection at a level rough

117 ma (IFN-gamma) are required for clearance of murine cytomegalovirus (MCMV) infection from the salivar

118 oting antiviral defense in the liver against murine cytomegalovirus (MCMV) infection have been charac

119 Murine cytomegalovirus (MCMV) infection in the lungs of

120 s by which natural killer (NK) cells control murine cytomegalovirus (MCMV) infection in the spleens a

121 Macrophages play an important role in murine cytomegalovirus (MCMV) infection in vivo, both in

122 ckout (KO) mice produce more IFN-alpha after murine cytomegalovirus (mCMV) infection in vivo.

123 HIF1a) is a feature of mouse NK cells during murine cytomegalovirus (MCMV) infection in vivo.

124 Having previously demonstrated that murine cytomegalovirus (MCMV) infection of apolipoprotei

125 Murine cytomegalovirus (MCMV) infection of mice induces

126 Here, we demonstrate that intermittent murine cytomegalovirus (MCMV) infection of mice, alters

127 at retinal neurons are infected early during murine cytomegalovirus (MCMV) infection of the inner ret

128 IM)-dependent programmed necrosis induced by murine cytomegalovirus (MCMV) infection or death recepto

129 Murine cytomegalovirus (MCMV) infection severely impaire

130 y been demonstrated to be protective against murine cytomegalovirus (MCMV) infection, and we show her

131 r mTOR signaling events were observed during murine cytomegalovirus (MCMV) infection, and we utilized

132 In murine cytomegalovirus (MCMV) infection, pDC depletion r

133 s play a pivotal role in the pathogenesis of murine cytomegalovirus (MCMV) infection, providing funct

134 During persistent murine cytomegalovirus (MCMV) infection, the T cell resp

135 ver, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified t

136 with Toll-like receptor-7 and -9 ligands, or murine cytomegalovirus (MCMV) infection.

137 cells are essential for the early control of murine cytomegalovirus (MCMV) infection.

138 important early mediator of host immunity to murine cytomegalovirus (MCMV) infection.

139 ammaRs on brain-resident microglia following murine cytomegalovirus (MCMV) infection.

140 y key roles in acute, persistent, and latent murine cytomegalovirus (MCMV) infection.

141 retinoids can alter the outcome of an acute murine cytomegalovirus (MCMV) infection.

142 role of interferon gamma (IFN-gamma) during murine cytomegalovirus (MCMV) infection.

143 ical CD8(+) T cell effector responses during murine cytomegalovirus (MCMV) infection.

144 in significantly increased susceptibility to murine cytomegalovirus (MCMV) infection.

145 ent function and increased susceptibility to murine cytomegalovirus (MCMV) infection.

146 ler (NK) cells mediate defense against early murine cytomegalovirus (MCMV) infections in liver.

147 nce during some virus infections--especially murine cytomegalovirus (MCMV) infections in mice and per

148 ic cytotoxic T lymphocytes (CTLs) and during murine cytomegalovirus (MCMV) infections of the livers o

149 ller (NK) cell inflammation in livers during murine cytomegalovirus (MCMV) infections, and NK cell-pr

150 ceptor confers in vivo genetic resistance to murine cytomegalovirus (MCMV) infections, but its ligand

151 iate downstream protective responses against murine cytomegalovirus (MCMV) infections.

152 Murine cytomegalovirus (MCMV) interferes with antigen pr

153 plantation of kidneys latently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc(scid) IL

154 acute infection with the hepatotropic virus murine cytomegalovirus (MCMV) involves complex cytokine

155 st host immune responses the betaherpesvirus murine cytomegalovirus (MCMV) is able to establish lifel

156 revious studies showed that establishment of murine cytomegalovirus (MCMV) latency in vivo is associa

157 The protease domain of the murine cytomegalovirus (MCMV) M80 open reading frame was

158 have been identified in the closely related murine cytomegalovirus (MCMV) mouse model, revealing nov

159 We used a live attenuated murine cytomegalovirus (MCMV) mutant to analyze mechanis

160 We have recently generated a pool of murine cytomegalovirus (MCMV) mutants by using a Tn3-bas

161 We had previously constructed a pool of murine cytomegalovirus (MCMV) mutants that contained a T

162 A pool of murine cytomegalovirus (MCMV) mutants was generated by u

163 A pool of murine cytomegalovirus (MCMV) mutants was previously gen

164 enesis approach, we have generated a pool of murine cytomegalovirus (MCMV) mutants.

165 We report the specific collision of a single murine cytomegalovirus (MCMV) on a platinum ultramicroel

166 ort observations of stochastic collisions of murine cytomegalovirus (MCMV) on ultramicroelectrodes (U

167 ll levels against the natural mouse pathogen murine cytomegalovirus (MCMV) or the human pathogen herp

168 binding of monosubstituted analogues of the murine cytomegalovirus (MCMV) pp89 168-176 and the tum-

169 NK cells were able to respond to a specific murine cytomegalovirus (MCMV) protein and that in the ab

170 al immunization with plasmids expressing the murine cytomegalovirus (MCMV) protein IE1-pp89 or M84 pr

171 The murine cytomegalovirus (MCMV) protein m4/gp34 is unique

172 In this study, we report that murine cytomegalovirus (MCMV) protein pM92 regulates vir

173 The murine cytomegalovirus (MCMV) proteins encoded by US22 g

174 pping mRNA region of M80.5 and protease, two murine cytomegalovirus (MCMV) proteins essential for vir

175 Murine cytomegalovirus (MCMV) rapidly induces activation

176 Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivar

177 NK cell-mediated murine cytomegalovirus (MCMV) resistance (Cmv(r)) is und

178 Murine cytomegalovirus (MCMV) respiratory dissemination

179 fection of YAC transgenic NIH 3T3 lines with murine cytomegalovirus (MCMV) resulted in lower (more th

180 Using an established model of experimental murine cytomegalovirus (MCMV) retinitis in mice with ret

181 resistance or susceptibility to experimental murine cytomegalovirus (MCMV) retinitis in mice.

182 poptosis contribute to retinal damage during murine cytomegalovirus (MCMV) retinitis, and TNF-alpha i

183 apoptosis is involved in the pathogenesis of murine cytomegalovirus (MCMV) retinitis.

184 During primary infection, murine cytomegalovirus (MCMV) spreads systemically, resu

185 that IPC and dendritic cells (DC) recognize murine cytomegalovirus (MCMV) through TLR9.

186 a coli Tn3 was introduced into the genome of murine cytomegalovirus (MCMV) to generate a pool of vira

187 P-1 transgenic mice with a sublethal dose of murine cytomegalovirus (MCMV) to look for evidence of ac

188 ood-retina barrier (BRB) increases spread of murine cytomegalovirus (MCMV) to the eye after intraperi

189 Proteins associated with the murine cytomegalovirus (MCMV) viral particle were identi

190 Stable assembly of murine cytomegalovirus (MCMV) virions in differentiated

191 In this study, murine cytomegalovirus (MCMV) was used as a persistent i

192 odel to study the outcomes of acquisition of murine cytomegalovirus (MCMV) when neonates are breastfe

193 MV) with EC(50) of 6.8 and 7.5 microM and of murine cytomegalovirus (MCMV) with EC(50) of 11.3 microM

194 control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA bet

195 Here we show that murine cytomegalovirus (MCMV), a prototypic beta-herpesv

196 mber of the beta subfamily of herpesviruses, murine cytomegalovirus (MCMV), and now report that produ

197 entified three open reading frames (ORFs) in murine cytomegalovirus (MCMV), designated M82, M83, and

198 M33, encoded by murine cytomegalovirus (MCMV), is a member of the UL33 h

199 identified two open reading frames (ORFs) of murine cytomegalovirus (MCMV), M83 and M84, which are pu

200 cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous fo

201 o lymphocytic choriomeningitis virus (LCMV), murine cytomegalovirus (MCMV), or influenza A virus enha

202 We found that, in murine cytomegalovirus (MCMV), the immunoevasin m138/fcr

203 In the case of murine cytomegalovirus (MCMV), the protein products of t

204 infected with human cytomegalovirus (HCMV), murine cytomegalovirus (MCMV), vaccinia (VV), and cowpox

205 We infected these mice with murine cytomegalovirus (mCMV), where Ccl3 and NK cells a

206 Such is the case for murine cytomegalovirus (MCMV), where deletion of the M33

207 rget the mRNA encoding the protease (mPR) of murine cytomegalovirus (MCMV), which is essential for vi

208 hat this process is markedly enhanced by the murine cytomegalovirus (MCMV)-encoded CC chemokine, MCK2

209 Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppres

210 ously expresses m157 (m157-Tg), which is the murine cytomegalovirus (MCMV)-encoded ligand for the Ly4

211 This murine cytomegalovirus (MCMV)-encoded protein, m12, rest

212 A murine cytomegalovirus (MCMV)-encoded protein, m157, has

213 as to determine whether adoptive transfer of murine cytomegalovirus (MCMV)-immune lymph node cells pr

214 on of these cytokines during adenovirus- and murine cytomegalovirus (MCMV)-induced hepatitis.

215 human fibroblasts as it has been shown to in murine cytomegalovirus (MCMV)-infected 4E-BP1(-/-) mouse

216 ired for infection with the beta-herpesvirus murine cytomegalovirus (MCMV).

217 urther analyzed after in vivo infection with murine cytomegalovirus (MCMV).

218 of the bacterium Listeria monocytogenes and murine cytomegalovirus (MCMV).

219 receptor Ly49H is required for resistance to murine cytomegalovirus (MCMV).

220 plasmid system to generate mutant strains of murine cytomegalovirus (MCMV).

221 tin rescue C57BL/6 mice were inoculated with murine cytomegalovirus (mCMV).

222 ymphocytic choriomeningitis virus (LCMV) and murine cytomegalovirus (MCMV).

223 free-living mouse populations infected with murine cytomegalovirus (MCMV).

224 +) T cells induced by chronic infection with murine cytomegalovirus (MCMV).

225 ted mice and mice infected intranasally with murine cytomegalovirus (MCMV).

226 Intraglandular infection of mice with murine cytomegalovirus (MCMV; control: UV-inactivated MC

227 Both human cytomegaloviruses (HCMVs) and murine cytomegaloviruses (MCMVs) encode multiple genes t

228 igated the effect of systemic infection with murine cytomegalovirus on the distribution and dynamics

229 R3(WT) littermates with the beta-herpesvirus murine cytomegalovirus or the poxvirus vaccinia virus.

230 In murine cytomegalovirus, poorly conserved sequences dista

231 re we report the surprising finding that the murine cytomegalovirus protein M45, a component of viral

232 ovirus as the T-cell responses to irrelative murine cytomegalovirus remained unimpaired.

233 d accordingly, M33 is required for efficient murine cytomegalovirus replication in the mouse.

234 ritoneal inoculation of newborn animals with murine cytomegalovirus resulted in virus replication in

235 lar endothelial cells, laboratory strains of murine cytomegalovirus retain this ability.

236 Additionally, separation of the murine cytomegalovirus-specific T cells into CD8+ and CD

237 Experimental animals received murine cytomegalovirus-specific T cells or subsets of T

238 Adoptive transfer of murine cytomegalovirus-specific T cells, but not herpes

239 Murine cytomegalovirus strain v70 induces a rapid and se

240 mandibular gland with tissue culture-derived murine cytomegalovirus (tcMCMV) or replication-deficient

241 R(-/-) mice exhibited increased clearance of murine cytomegalovirus that correlated with increased le

242 Murine cytomegalovirus triggers both apoptosis and necro

243 us which normally lacks invertible elements (murine cytomegalovirus), we created a genome composed of

244 , the genomes of the chimpanzee, rhesus, and murine cytomegaloviruses were searched for orthologues o

245 ed with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly sim

246 Cmv1, the gene that determines resistance to murine cytomegalovirus, which is encoded in the major NK

247 cess, we constructed a number of recombinant murine cytomegaloviruses with a second cleavage site ins