ライフサイエンスコーパス: murine model

1 red from a growth-factor driven glioblastoma murine model.

2 ociated protein of 70 kDa (ZAP-70)-deficient murine model.

3 tification of ongoing lung inflammation in a murine model.

4 icacy and HLH-like toxicities in a syngeneic murine model.

5 t vaccine (rgD-2) in a primary lethal ocular murine model.

6 their ability to induce oral tolerance in a murine model.

7 gainst a lethal dose of HSV-2 infection in a murine model.

8 n preclinical studies with human cells and a murine model.

9 rf(-/-) BCR-ABL acute lymphoblastic leukemia murine model.

10 rin production in vitro and in vivo in a CEP murine model.

11 ection and allergic airway inflammation in a murine model.

12 accelerates Randall's plaque formation in a murine model.

13 ifically killing in vitro and in a xenograft murine model.

14 eta-thalassemia intermedia in the Hbbth1/th1 murine model.

15 raft pancreatic cancer (BxPC-3) tumours in a murine model.

16 late the pathogenesis of Chagas disease in a murine model.

17 ion, and T-cell cross-reactivity in a BALB/c murine model.

18 scular inflammation and atherosclerosis in a murine model.

19 f disease during inflammatory arthritis in a murine model.

20 linically relevant S. aureus wound infection murine model.

21 on and ameliorated newborn microcephaly in a murine model.

22 istant Acinetobacter baumannii infections in murine models.

23 -A in cell lines, xenografts, and transgenic murine models.

24 s, along with in vivo assays utilizing three murine models.

25 , which is in line with previous findings in murine models.

26 (86)Y-NM600 were noted in both 4T07 and 4T1 murine models.

27 ed lung metastasis in spontaneous metastatic murine models.

28 al systems, including yeast, Drosophila, and murine models.

29 insight into the pathogenesis of disease in murine models.

30 infiltration followed by tumor regression in murine models.

31 ry genes in vitro and airway inflammation in murine models.

32 healthy controls (n = 30), and experimental murine models.

33 rmal delivery of powder hydrophilic drugs in murine models.

34 tion following intravenous administration in murine models.

35 for preclinical research in immunocompetent murine models.

36 -treated tumors from sensitive and resistant murine models.

37 ay promote gene function studies using novel murine models.

38 tumor-vascular interface using conventional murine models alone.

39 In a murine model, Alp1 elicits helper T (Th) cell-dependent

40 Here, our work in a murine model and in human patients indicates that neutra

41 ized the HLH-like syndromes occurring in the murine model and in humans.

42 nologic PET imaging of multiple myeloma in a murine model and in humans.

43 ng is an important determinant of NAFLD in a murine model and is associated with NAFLD in humans.

44 ability to promote endochondral repair in a murine model and uncover mechanisms that will serve to f

45 s has been extensively studied using in vivo murine models and cell lines, typically challenged with

46 e key for the transition between preclinical murine models and clinical applications.

47 In multiple murine models and clinical datasets, we identified large

48 Evidence from murine models and human post-mortem studies indicates th

49 re elicited by trypanosome infection in both murine models and human sleeping sickness patients.

50 These trials could bridge murine models and human trials and better prioritize dru

51 airway eosinophilia and asthma phenotypes in murine models and inhibited IL-13-induced eosinophil bin

52 and interfering with antigen presentation in murine models and patient tumors.

53 Using autochthonous STS murine models and unbiased metabolomics, we demonstrate

54 ovirus boost vaccination via the airway in a murine model, and demonstrate this approach may be able

55 ly, PTEN null human cancer cells and in vivo murine models are sensitive to anti-PPP treatments, sugg

56 chia coli can inhibit autoimmune diseases in murine models by inducing bystander tolerance.

57 The murine model closely mirrors human disease, and thus, th

58 d significant systemic efficacy in different murine models comparable to conventional antibiotics.

59 of clinical data and longitudinal studies of murine models continue to provide insight into the natur

60 a large subset of human glioma specimens and murine models correlates with increased tumor-associated

61 In murine models, CX-6258 induced a potent cGAS-dependent t

62 is elevated in prostate cancer, and a novel murine model demonstrated a hyperproliferative phenotype

63 al characterization of the proteins, using a murine model, demonstrated that robust anti-CS6 immune r

64 In vivo studies using a murine model displayed that the recombinant Asp t 36 was

65 med mechanistic studies in two Pten knock-in murine models, distinct from each other in cell compartm

66 The currently available murine model does not fully simulate human IOPD, display

67 In a murine model, E. coli K1 grew rapidly in the peritoneal

68 a suggest that GL261 Red-FLuc and GL261-Luc2 murine models elicit an anti-tumor immune response by in

69 abetic full-thickness splinted wound healing murine model enhanced the microcirculatory blood flow an

70 h this association is established in humans, murine models failed to fully recapitulate the reproduct

71 E. coli (EHEC) and Citrobacter rodentium, a murine model for EHEC.

72 Here, we generate a murine model for the Slc39a8 A391T allele and demonstrat

73 eveal that excessive placental DNA damage in murine models for Cornelia de Lange syndrome results in

74 Murine models help to better understand the dynamic proc

75 Mild traumatic brain injury (mTBI) in a murine model increases survival to a bacterial pulmonary

76 mation, and cyst growth, we used conditional murine models involving postdevelopmental ablation of Pk

77 In murine models, it has been shown that the extracellular

78 e genetically ablated it in an autochthonous murine model (KrasG12D; Pdx-1cre, KC), which mirrors the

79 s and patients with PAH, analyses of genetic murine models lacking specific complement components or

80 ing CEACAM1 on NETs, or knocking it out in a murine model, leads to a significant decrease in colon c

81 roduction were assessed in cell cultures and murine models.Measurements and Main Results: Ceramide is

82 rated that genome-wide expression in our new murine model more closely approximated human surgical se

83 g the immune-specific characteristics of the murine models most commonly used in HNC research, includ

84 To test this hypothesis, we developed a murine model of 'triple-disease' in which mice rendered

85 ix remodeling and inflammatory activity in a murine model of AAA.

86 feres with lung recovery and remodeling in a murine model of acute lung injury.

87 ing time-sequential bulk RNA-seq data from a murine model of acute myeloid leukemia (AML).

88 is strain displayed decreased virulence in a murine model of acute pneumonia compared to USA300 (curr

89 turnover is important for pathogenesis in a murine model of acute pneumonia.

90 lly relevant unilateral ischemia-reperfusion murine model of AKI at days 1, 2, 4, 7, 11, and 14 after

91 desis and bronchial hyperresponsiveness in a murine model of allergic lung inflammation.

92 In a murine model of AML, dual treatment with MTP-PE and IFN-

93 beta and reduced neutrophil recruitment in a murine model of antibody-mediated nephritis.

94 lthy mice (wild type; WT) and from a genetic murine model of arrhythmic disease (catecholaminergic ve

95 In a murine model of aspergillosis, the Deltagna1 mutant stra

96 Using a murine model of asystolic cardiac arrest, we discovered

97 al distribution of Fap-expressing cells in a murine model of atherosclerosis and used a genetic appro

98 macrophages in cell culture and in vivo in a murine model of atherosclerosis.

99 In the murine model of BA, rhesus rotavirus (RRV) infection of

100 optosis and exhibited reduced virulence in a murine model of bacterial infection.

101 The KI/KO mP215L strain is the first murine model of BAG3 myopathy that resembles the human s

102 In summary, we describe a murine model of broad and immediate utility to investiga

103 Here, we used a murine model of C. difficile disease recurrence to demon

104 A novel, rapidly progressing, severe, murine model of C3G was developed by replacing the mouse

105 rmed in vivo with an angiotensin II-mediated murine model of cardiac fibrosis in both preventive and

106 results in a significant fitness defect in a murine model of CAUTI, but YntA is more crucial as the y

107 In a murine model of CCA, recruited PD-L1+ TAMs facilitated C

108 ity in a dose-dependent manner in vitro In a murine model of CDI, exogenous administration of ursodio

109 d consequent allergic lung inflammation in a murine model of chronic asthma.

110 methane and dextran sodium sulfate (AOM/DSS) murine model of colitis-associated carcinoma, we previou

111 e is critical for colon tumor formation in a murine model of colitis-associated tumorigenesis and STE

112 Here, we adopted a murine model of complete mismatch full-thickness skin tr

113 of Blood, Blouin et al describe studies in a murine model of congenital erythropoietic porphyria (CEP

114 Using a well-characterized murine model of corneal transplantation, we report that

115 provide long-term modulation of allergy in a murine model of cow's milk allergy.

116 as effective in suppressing arrhythmias in a murine model of CPVT.

117 Using a murine model of elastase-induced emphysema we demonstrat

118 Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD)

119 s the development of multiple sclerosis in a murine model of experimental autoimmune encephalomyeliti

120 P. gingivalis infection were evaluated in a murine model of experimental periodontitis.

121 accine-induced protective immunity against a murine model of experimental Q fever requires MHC-II-res

122 Using an in vivo murine model of focal demyelination, we find that BZA en

123 vity against intracellular Burkholderia In a murine model of fulminant respiratory melioidosis, treat

124 t the absence of CD73 improved survival in a murine model of glioblastoma multiforme treated with ant

125 Using a murine model of heart tolerance, we showed that alloreac

126 We utilized the murine model of hindlimb ischemia, and in vivo Matrigel

127 n deposition after microvascular injury in a murine model of HIT in which human FcgammaRIIa was expre

128 merization attenuate thrombus formation in a murine model of HIT.

129 Using ex vivo assays, a murine model of HLH, and primary patient samples, we dem

130 itudinal therapy studies were conducted in a murine model of human colorectal carcinoma using an immu

131 s can be interchanged both in vitro and in a murine model of infection in vivo.

132 Here we used a murine model of infection with a Francisella attenuated

133 cies, produced adverse effects in an in vivo murine model of infection with the highly pathogenic bac

134 Using Cryptococcus deneoformans in a murine model of infection, we examined contributors to d

135 of front line anti-TB drug Isoniazid in the murine model of infection.

136 Here, we used a murine model of intrapulmonary Streptococcus pneumoniae

137 rapid disease progression and mortality in a murine model of invasive aspergillosis.

138 ectrum antifungal activity and efficacy in a murine model of invasive fungal infection.

139 Here, we employ a sensitized murine model of islet transplantation to test strategies

140 ndent manner and tested this hypothesis in a murine model of KEL alloimmunization.

141 ant thrombomodulin (rTM), were compared in a murine model of kidney IRI.

142 he effects of fingolimod in twitcher mice, a murine model of Krabbe's disease.

143 and to examine its safety and efficacy in a murine model of lethal HSV-2 infection.

144 We employ a novel murine model of liver lymphangiography and in vivo micro

145 sine-modified fibronectin was increased in a murine model of lung fibrosis and in human subjects with

146 An orthotopic murine model of lung transplant using lymphatic reporter

147 Here, using a murine model of malaria and combining single-cell RNA se

148 and mice) and murine macrophages and using a murine model of mastitis.

149 In this study, we developed a murine model of MAYV infection that emulates many of the

150 nsitivity to immune checkpoint blockade in a murine model of melanoma.

151 Finally, in a pre-clinical murine model of metastatic breast cancer, treatment with

152 By using a murine model of MFS, fibrillin-1 hypomorphic mgR mice, w

153 ntly sustained emergency granulopoiesis in a murine model of MLL1-rearranged AML, associated with acc

154 The murine model of MS is the experimental autoimmune enceph

155 mental autoimmune encephalomyelitis (EAE), a murine model of MS, adoptive transfer of IL-10(+) regula

156 rimental allergic encephalomyelitis (EAE), a murine model of multiple sclerosis.

157 ecule inhibitors in a genetically engineered murine model of MYCN-driven neuroblastoma.

158 Here we used our neonatal murine model of NEC-related thrombocytopenia to investig

159 nd antigen-specific T cell reactivity in the murine model of nephrotoxic nephritis.

160 was tested in a nondiabetic, T-cell-mediated murine model of nephrotoxic serum nephritis (NTS).

161 64D), and a spontaneous transgenic (TH-MYCN) murine model of neuroblastoma, comparing histological fe

162 Using a murine model of nHSV, we demonstrated that maternal immu

163 T/C-28a2), primary human chondrocytes, and a murine model of OA by transmission electron microscopy a

164 gnificantly reduced OA cartilage damage in a murine model of obesity-induced OA.

165 HSV-1 infection and disease progression in a murine model of ocular infection.

166 We developed a murine model of orthopaedic trauma combining tibia fract

167 Using a murine model of osteomyelitis, we examined survival of S

168 ted glycoprotein 72-positive xenografts in a murine model of ovarian cancer.

169 We demonstrate retinal fibrosis within a murine model of oxygen-induced retinopathy resulting fro

170 In a hypomorphic murine model of PA, dual mRNAs normalize ammonia similar

171 In an orthotopic murine model of pancreatic cancer, AES-135 prolongs surv

172 EP2 or EP4 receptor agonists were used in a murine model of passive systemic anaphylaxis.

173 Thus, a murine model of perforin-deficient CAR T cells recapitul

174 Using bone marrow-derived macrophages and a murine model of peritonitis, we show in this study that

175 The in vivo action was evaluated in a murine model of Phl p 5 allergic sensitization.

176 ly, DeltamumR exhibited reduced fitness in a murine model of pneumonia, indicating that MumR-regulate

177 ional in an influenza A virus superinfection murine model of pneumonia, paving the way for in vivo in

178 ivated for hutH are severely attenuated in a murine model of pneumonia.

179 In a murine model of polymicrobial infection (cecal ligature

180 gated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia.

181 n psoriasis cohorts and the K14-Rac1V12(-/+) murine model of psoriasis to investigate PCSK9 and cardi

182 ting TLR7-induced pathology in a preclinical murine model of psoriasis.

183 For animal modeling, we used a murine model of pulmonary fibrosis in conventional and g

184 rk describes the first nongenetically driven murine model of pulmonary hypertension (PH) that generat

185 By using a murine model of pulmonary tuberculosis (TB), we have inv

186 Using a murine model of recurrent bacteremia, we demonstrate tha

187 ds and reduced colonization persistence in a murine model of relapse C. difficile infection.

188 In a murine model of renal fibrosis induced by unilateral ure

189 arenteral application of Nano-mupirocin in a murine model of S. aureus bloodstream infection resulted

190 ion of mortality-associated pathways using a murine model of SaB.

191 In a murine model of SARS-CoV-2 infection, 2B04 protected cha

192 the CRISPR-Cas9 system to a well-established murine model of SCLC to rapidly model loss-of-function m

193 Also, we found that during a murine model of sepsis, P2X7 receptor activity is import

194 children with septic shock and in a juvenile murine model of sepsis.

195 Cecal slurry murine model of sepsis; survival studies in juvenile and

196 the survival of the mottled-brindled mouse-a murine model of severe Menkes disease.

197 In this study, using a murine model of smoke-induced COPD, we demonstrate that

198 duced pancreatitis, and in an oncogenic Kras murine model of spontaneous pancreatic ductal adenocarci

199 In a murine model of sterile kidney injury, reduced neutrophi

200 ile topical administration of such drug in a murine model of surgical wound infection significantly r

201 fects of synthetic LXR agonist TO901317 in a murine model of syngeneic Lewis Lung carcinoma.

202 ith heat-killed encapsulated strain WU2 in a murine model of systemic infection resulted in encapsula

203 Using a murine model of systemic infection, we observed tcyP-dep

204 Here we used a diet-induced murine model of T2D to investigate the underlying mechan

205 Interestingly, in the murine model of TB, induction of autophagy eliminated M.

206 ests and synaptic plasticity phenotypes in a murine model of the disease.

207 Here, we have developed a novel murine model of the EPR to allow for mechanistic studies

208 ation across the entire graft thickness in a murine model of transplant immunosuppression.

209 CCT2 depletion in a syngeneic murine model of triple negative breast cancer (TNBC) pre

210 tablish and maintain chronic infections in a murine model of tuberculosis.

211 al-endothelial barrier as well as an in vivo murine model of type II diabetes.

212 using mouse adult fibroblasts from the novel murine model of USP22 expression.

213 PS-stimulated rat monocytes and in vivo on a murine model of UVB-induced skin burns.

214 ounds was synthesized and tested against the murine model of visceral leishmaniasis.

215 he connection between mucosa and joints in a murine model of Yersinia enterocolitica O:3-induced reac

216 Here, using murine models of 22q11-deletion syndrome (22q11DS), whic

217 ase regulator, crucially controls disease in murine models of adriamycin (ADR)-induced focal and segm

218 e pre-exposure prophylactic in highly lethal murine models of aerosolized human pulmonary melioidosis

219 al transcriptome profiling in three distinct murine models of AKI.

220 view insights obtained from experiments with murine models of allergic airway and skin inflammation a

221 ral to the development of GVHD in the gut in murine models of allogeneic bone marrow transplantation

222 Similar synapse loss is observed in three murine models of Alzheimer-related neurodegeneration, wh

223 cological activity in cellular and xenograft murine models of AML.

224 It is efficacious in murine models of both acute and established infection, a

225 Using murine models of both perinatal and postnatal GBS acquis

226 ism that mediates skeletal muscle wasting in murine models of cancer cachexia that is disrupted in sk

227 expression profiling was performed between 2 murine models of cardiac pressure overload, transverse a

228 Murine models of chronic alcohol consumption are frequen

229 p in Tie2 expression observed across various murine models of critical illnesses is associated with i

230 eted chemotherapy when paired with MRgFUS in murine models of DIPG.

231 etes correlates with dyslipidemia in man and murine models of disease.

232 Using murine models of enteric infections, we observed long-te

233 al 3-dimensional model system (EPC2-ALI) and murine models of EoE to define the relationship between

234 Both perinatal and postnatal murine models of GBS acquisition closely recapitulate th

235 ma-globin and illustrate potential limits of murine models of globin gene regulation.

236 te utilization genes and impaired fitness in murine models of infection.

237 Historically, murine models of inflammation in biomedical research hav

238 of secondary cellular damage and recovery in murine models of injury.

239 lopment of NC mice, we employed two distinct murine models of iNKT cell over-representation: Vbeta8 T

240 Corroborating our findings from the murine models of iron deficiency anemia, primary human M

241 ng system for changes in subchondral bone in murine models of knee osteoarthritis (OA), three key par

242 astid proteasome, which cleared parasites in murine models of leishmaniasis, Chagas disease, and huma

243 We have used in vivo murine models of MM to show significant induction of ner

244 cells reduced BMAT in different preclinical murine models of multiple myeloma and in vitro using mye

245 Murine models of Mycobacterium tuberculosis (Mtb) infect

246 myelin regeneration across two experimental murine models of myelin injury.

247 ndings were demonstrated in lean and nonlean murine models of NAFLD.

248 therapy using two orthotopic immunocompetent murine models of non-small cell lung cancer: CMT167 (CMT

249 ay expression analysis, and generated unique murine models of P-Rex1 gain or loss of function.

250 Here, by using murine models of pB-ALL, we show that microbiome disturb

251 d extends survival of genetically-engineered murine models of PDA.

252 s), which is a cell population implicated in murine models of pulmonary fibrosis.

253 rvival benefit in multiple highly aggressive murine models of SCLC, providing a rationale for new com

254 the release of NDPs, and improves outcome in murine models of sepsis.

255 In several murine models of transplantation, the "cross-dressing" o

256 We studied several murine models of Ubqln2-linked ALS and also generated Ub

257 In contrast, in our murine models PilA was consistently found to be more imm

258 icles, and upon oral administration to a PKD murine model (Pkd1(fl/fl);Pax8-rtTA;Tet-O cre), a lower

259 at the CRISPR-Cas9 generated Gaa(c.1826dupA) murine model recapitulates hypertrophic cardiomyopathy a

260 1 in the skin cells of a BRAF(V600E)-mutated murine model reduced cancer cell death and promoted mela

261 es in the familial Alzheimer's disease 5xFAD murine model revealed beneficial effects in behavior and

262 Moreover, a murine model reveals that Fe(3+) crosslinked foam displa

263 The infectious course and pathologies in the murine model showed similarity to prior observations of

264 Murine models showed that cancer has the slowest progres

265 effects of acute oxaliplatin treatment in a murine model, showing that male and female mice develop

266 Murine modeling shows that neurogenesis is likely altere

267 In the murine model, substantial bone marrow uptake was seen in

268 Murine models suggest that opioids alter the gut microbi

269 Recent research in murine models suggests that parkin and PINK1 deficiency

270 inhibited tumor growth in a HCT116 xenograft murine model, supporting that SIRT2 is a viable therapeu

271 ient (ApoE(-/-)) atherosclerosis progression murine model, T1317-sHDL showed superior inhibition of a

272 In murine models, Tcf21 is required for phenotypic modulati

273 Here, we describe a murine model that can be utilized to study mucosal (orop

274 h, and discuss emerging methods for creating murine models that better reflect the genetic basis of t

275 In a peritoneal sepsis murine model, the minimum lethal dose required by A. bau

276 tudy provided the first evidence that in the murine model, the serum level and anaphylactic activity

277 When applied to a murine model these proinsulin-coated MNs efficiently pun

278 xia-associated IUGR, we used an experimental murine model to determine whether such effects may be at

279 identifying the preclinical utility of this murine model to interrogate subtype-specific differences

280 logy, and reagents from genetically modified murine models to test their hypothesis that downregulati

281 n this study, the prostate cancer multistage murine model TRAMP and TRAMP-derived cells have been use

282 onsense mutation in the Eml1 gene in a novel murine model, tvrm360, displaying subcortical heterotopi

283 r-associated urinary tract infection (CAUTI) murine model using UPAB1, a recent MDR urinary isolate.

284 A murine model was used to confirm their antigenicity and

285 Using a murine model we previously identified that HCM causing c

286 In a murine model, we demonstrate chronic treatment with carv

287 st M. tuberculosis In this study, by using a murine model, we detail whether respiratory mucosal TB v

288 Using a murine model, we examined the impact of 30 d of IH (IH(3

289 In a cutaneous tissue injury murine model, we found that TLR4 expression is dynamic i

290 Here, using a murine model, we investigated the phenotypic impacts of

291 In a transgenic murine model, we show that calcium predicts the BOLD sig

292 To verify findings from the murine models, we analyze ARID1A(WT) and ARID1A(KO) huma

293 ed that the majority of affected proteins in murine models were upregulated in patients.

294 ls and induce tumor regression in GPRC5D+ MM murine models, which coincide with T-cell infiltration a

295 we tested this hypothesis in wobbler mice, a murine model with a homozygous partial loss-of-function

296 heterozygous conditional knock out (het CKO) murine model with central nervous system (CNS)-specific

297 genesis, we establish genetically engineered murine models with Arid1a and/or Pten conditional deleti

298 s of lncRNAs have been revealed primarily in murine models with limited understanding of lncRNAs in h

299 This review summarizes available murine models with systemic or organ-specific deletion o

300 cellent in vivo antimalarial efficacy in the murine model without noticeable toxicity.