ライフサイエンスコーパス: muscle differentiation

1 ing Myocardin, which prevented airway smooth muscle differentiation.

2 , diseases linked to loss of vascular smooth muscle differentiation.

3 ent, including mesenchymal growth and smooth muscle differentiation.

4 channels is a pivotal event during skeletal muscle differentiation.

5 of Map4k4 is essential for its inhibition of muscle differentiation.

6 ressive pediatric cancer exhibiting skeletal-muscle differentiation.

7 f DEFB103, a human defensin that can inhibit muscle differentiation.

8 oth muscle precursors is required for smooth muscle differentiation.

9 activity and consequently inhibited skeletal muscle differentiation.

10 key molecular link between O(2) and skeletal muscle differentiation.

11 s involved in Sharp-1-mediated inhibition of muscle differentiation.

12 as a negative regulator of mTOR activity and muscle differentiation.

13 atively regulates mTOR activity and skeletal muscle differentiation.

14 s slow fiber gene expression during skeletal muscle differentiation.

15 low fiber type specification during skeletal muscle differentiation.

16 ors and histone-modifying enzymes that shape muscle differentiation.

17 gulator Myocardin (Myocd) and induces smooth muscle differentiation.

18 likely due to the role of miR-1a in cardiac muscle differentiation.

19 ctor is important for all types of embryonic muscle differentiation.

20 erentiation with subsequent increased smooth muscle differentiation.

21 hich arrested during the process of skeletal muscle differentiation.

22 ulates myogenic transcription factors during muscle differentiation.

23 indicating that CTCF regulates MRF-mediated muscle differentiation.

24 ciated genes in ARMS cells, thereby blocking muscle differentiation.

25 s agents that mediate cytostasis and promote muscle differentiation.

26 ing M2c macrophage activation and modulating muscle differentiation.

27 overcome the inhibitory effects of MBNL3 on muscle differentiation.

28 ox transcription factor that is critical for muscle differentiation.

29 through induction of microRNAs during smooth muscle differentiation.

30 ying an important role in attenuating smooth muscle differentiation.

31 and two KLF3 isoforms are upregulated during muscle differentiation.

32 ription factor that plays essential roles in muscle differentiation.

33 to Igf2 promoters is also an early event in muscle differentiation.

34 erating stem cells and later promotes smooth muscle differentiation.

35 ity to study the systems-level properties of muscle differentiation.

36 fferentiation, and Hand2 potentiates cardiac muscle differentiation.

37 is, we discovered one compound that controls muscle differentiation.

38 s may serve as markers of striated or smooth muscle differentiation.

39 grin subunit, is essential for morphological muscle differentiation.

40 a critical lineage determinant for skeletal muscle differentiation.

41 ng FAK regulation of myogenin expression and muscle differentiation.

42 t role for Pbx proteins in promoting cardiac muscle differentiation.

43 ortant signaling pathways linked to skeletal muscle differentiation.

44 keleton is a critical early step in skeletal muscle differentiation.

45 hich contains PRDM16, of which loss promotes muscle differentiation.

46 n at random, we identify 49 involved in late muscle differentiation.

47 t beta-catenin, not TCF/LEF, is required for muscle differentiation.

48 ss of brown fat characteristics and promotes muscle differentiation.

49 fied direct Stat3 target genes important for muscle differentiation.

50 xpression throughout the program of skeletal muscle differentiation.

51 APC, have been suggested to govern terminal muscle differentiation.

52 ence that Akt1 and not Akt2 is essential for muscle differentiation.

53 teins, Skp2 and Myf5, for proteolysis during muscle differentiation.

54 of primitive mesenchyme exhibiting skeletal muscle differentiation.

55 t regulates myogenin expression and skeletal muscle differentiation.

56 ct of the Msx1 gene is a potent inhibitor of muscle differentiation.

57 PK pathway directly during processes such as muscle differentiation.

58 functions in myoblasts to modulate skeletal muscle differentiation.

59 Myoblast fusion is an essential step during muscle differentiation.

60 wn of Cdh1 by siRNA significantly attenuates muscle differentiation.

61 3 or its pharmacological inhibition impaired muscle differentiation.

62 ctions as a negative regulator of late-stage muscle differentiation.

63 es associated with proliferation or terminal muscle differentiation.

64 transcription of target genes essential for muscle differentiation.

65 ential for sustaining the earliest events in muscle differentiation.

66 Ig/fibronectin superfamily members linked to muscle differentiation.

67 ssion of the late genes that induce terminal muscle differentiation.

68 protein, may play a critical role in cardiac muscle differentiation.

69 ack loop in the transcriptional circuitry of muscle differentiation.

70 that repress gene expression during skeletal muscle differentiation.

71 on, and the Ski and Hes6 genes have roles in muscle differentiation.

72 yncytial formation is a hallmark of skeletal muscle differentiation.

73 on of genes involved in cardiac and skeletal muscle differentiation.

74 t to promote notochord formation and prevent muscle differentiation.

75 meostasis which is downregulated in skeletal muscle differentiation.

76 3 ubiquitin ligase to repress human skeletal muscle differentiation.

77 activation of the Myog promoter to initiate muscle differentiation.

78 uning, clearance of neuronal debris, and for muscle differentiation.

79 nascent buds coincided with patterned smooth muscle differentiation.

80 ed for myogenic gene expression and skeletal muscle differentiation.

81 p, both of which are induced during skeletal muscle differentiation.

82 nvestigated the function of AUF1 in skeletal muscle differentiation.

83 sion between progenitor cell maintenance and muscle differentiation.

84 in myogenic factors and pathways involved in muscle differentiation.

85 gesting a role for this protein during early muscle differentiation.

86 ction of myocardin, a key mediator of smooth muscle differentiation.

87 role in the regulation of the final stage of muscle differentiation.

88 d cells, whereas an increase is required for muscle differentiation.

89 type and misregulation of genes involved in muscle differentiation.

90 ity and function as an inhibitor of skeletal muscle differentiation.

91 us Wnt signalling inhibitor for normal heart muscle differentiation.

92 res in which H19 depletion causes precocious muscle differentiation, a phenotype recapitulated by let

93 activation of Fbxl2 is required for skeletal muscle differentiation, a process that is interrupted by

94 minant-negative Set7 mutant impairs skeletal muscle differentiation, accompanied by a decrease in lev

95 hat Map4k4 is a novel suppressor of skeletal muscle differentiation, acting through a Myf5-dependent

96 do not display overt abnormalities in smooth muscle differentiation, although they show a significant

97 e expression during myofibroblast and smooth muscle differentiation, an event that is important for w

98 SMN in myotube formation through effects on muscle differentiation and cell motility.

99 ctor (SRF), which controls genes involved in muscle differentiation and cell proliferation.

100 exit sites takes place early during skeletal muscle differentiation and completely remodels the secre

101 oblasts have the ability to undergo skeletal muscle differentiation and cross the blood vessel wall r

102 Smooth muscle differentiation and distribution of early regiona

103 oop-helix transcription factor essential for muscle differentiation and enhances its binding to E box

104 cell cycle inhibitor essential for skeletal muscle differentiation and for survival.

105 functions are reflected in defects in smooth muscle differentiation and function in mice with mutatio

106 luster expressed genes that mediate skeletal muscle differentiation and function.

107 ave been reported to play a critical role in muscle differentiation and function.

108 novel role for EGLN3 in regulating skeletal muscle differentiation and gene expression.

109 ction between MyoD and Id1 in the process of muscle differentiation and have implications for the inv

110 K(v)7.4 plays a permissive role in skeletal muscle differentiation and highlight REST as a crucial t

111 We show that LOI results in defects in muscle differentiation and hypertrophy and identify prim

112 roRNAs that are dynamically regulated during muscle differentiation and hypertrophy identified microR

113 T14 and Y15 in cell cycle quiescence during muscle differentiation and implicate two muscle differen

114 of cytoskeletal remodelling processes during muscle differentiation and in adult cardiomyocytes.

115 transcriptional regulation of AdipoR1 during muscle differentiation and in obesity.

116 Depletion of 4.1R impairs skeletal muscle differentiation and is accompanied by a decrease

117 on factor, is a potent repressor of skeletal muscle differentiation and is dysregulated in muscle pat

118 MBNL3 functions as an inhibitor of muscle differentiation and is expressed in proliferating

119 miR-26a is induced during skeletal muscle differentiation and is predicted to target a well

120 etween transient and permanent repression of muscle differentiation and lineage commitment genes and

121 protein degradation and protein synthesis in muscle differentiation and metabolism under abnormal and

122 verexpression of SMYD3 in myoblasts promoted muscle differentiation and myoblasts fusion.

123 ther signal transduction pathways including: muscle differentiation and myopathies (MEF2C), tumor sup

124 role of SMYD3 in the regulation of skeletal muscle differentiation and myotube formation, partially

125 s of transcription with established roles in muscle differentiation and neuronal survival.

126 SRF is an essential regulator of skeletal muscle differentiation and numerous components of the mu

127 lated genes were mainly involved in skeletal muscle differentiation and proliferation, including IGF2

128 nts define a biological function for Set7 in muscle differentiation and provide a molecular mechanism

129 fine a novel biological function for 4.1R in muscle differentiation and provide a molecular mechanism

130 for the requirement of miR-26a for skeletal muscle differentiation and regeneration in vivo.

131 itical trans-regulatory function in skeletal muscle differentiation and regeneration that is mediated

132 on of a beta-tubulin isotype plays a role in muscle differentiation and regeneration.

133 examined the role of the H19 RNA in skeletal muscle differentiation and regeneration.

134 strate how these transcripts affect skeletal muscle differentiation and related disorders.

135 A expression and results in deficient smooth muscle differentiation and resultant aortic arch artery

136 ged1 in neural crest impairs vascular smooth muscle differentiation and results in aortic arch artery

137 w that FGF9 represses peribronchiolar smooth muscle differentiation and stimulates vascular developme

138 f SMN protein in the intrinsic regulation of muscle differentiation and suggest that abnormal muscle

139 icated TNFalpha-dependent miRNA circuitry in muscle differentiation and survival pathways in cancer.

140 rther define the role of myocardin in smooth muscle differentiation and vascular development.

141 For example, Myod drives skeletal muscle differentiation, and Hand2 potentiates cardiac mu

142 trophin (Utrn) is suppressed during skeletal muscle differentiation, and it is replaced at the sarcol

143 serum response factor, a master regulator of muscle differentiation, and negatively regulates its lev

144 ome-wide analysis of epigenetic marks during muscle differentiation, and strikingly, we observed a ne

145 cognised role in the earliest steps of heart muscle differentiation, and that partial complementation

146 modulate chromatin structure during skeletal muscle differentiation are still poorly understood.

147 control splicing patterns during neuron and muscle differentiation are the polypyrimidine tract-bind

148 ermed the Bruno body, and after the onset of muscle differentiation, Aret disperses in the nucleus.

149 Using muscle differentiation as a model system, we show that F

150 mors that displayed an inability to complete muscle differentiation as determined by histological app

151 trates that TBP2 does not replace TBP during muscle differentiation, as previously proposed, with lim

152 ISPR-Cas9 genome editing and in vitro smooth muscle differentiation assay, we demonstrate that CD146

153 ltransferase Prmt5 was required for skeletal muscle differentiation at the early stages of myogenesis

154 that sfrp1 is not only able to promote heart muscle differentiation but is also required for the form

155 pression of c-Ski/SnoN also induces skeletal muscle differentiation, but how c-Ski/SnoN function in m

156 ng promoted proliferation and induced smooth muscle differentiation, but inhibited myocardial differe

157 in expression are induced as early events in muscle differentiation, but the responsible molecular me

158 f2 family of transcription factors regulates muscle differentiation, but the specific gene programs c

159 in differentiated muscle cells and promotes muscle differentiation by activating serum response fact

160 -regulatory modules (CRMs) in human skeletal muscle differentiation by combining myogenic TF binding

161 te MEF2 transcriptional function in skeletal muscle differentiation by depleting individual MEF2 prot

162 These data suggest that MBNL3 antagonizes muscle differentiation by disrupting Mef2 beta-exon spli

163 we demonstrated myocardin coordinate smooth muscle differentiation by inducing transcription of micr

164 sed in ureteral mesenchyme, regulates smooth muscle differentiation by maintaining Shh1 responsivenes

165 ed changes in the chromatin landscape during muscle differentiation by mapping the genome-wide locati

166 Cdc25A is down-regulated during muscle differentiation by multiple pathways: action of t

167 p38-gamma puts the brakes on skeletal muscle differentiation by promoting the association of t

168 blast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.

169 SMYD3, revealed that SMYD3 impacts skeletal muscle differentiation by targeting the key muscle regul

170 At later stages, Shh promotes slow muscle differentiation cell-autonomously.

171 enhancer that confers promoter regulation by muscle differentiation, changes in intracellular calcium

172 During skeletal muscle differentiation, Cn activates the nuclear factor

173 chanisms in mediating the complex program of muscle differentiation determined by the E2A proteins.

174 egulatory cell function, neuronal disorders, muscle differentiation, development, and cancer.

175 factors that play pivotal roles in striated muscle differentiation, development, and metabolism, in

176 l induction that propagates a wave of smooth muscle differentiation during aortic arch artery develop

177 ranscription factors play essential roles in muscle differentiation during embryogenesis, but their p

178 myoblasts, demonstrating that the process of muscle differentiation enhances the loss of normal ISCU

179 This was unexpected, as MyoD is a muscle differentiation factor and not previously known t

180 The mechanisms that regulate skeletal muscle differentiation, fiber type diversity and muscle

181 neurin plays an important regulatory role in muscle differentiation, fiber-type determination, hypert

182 are employed at different times of skeletal muscle differentiation for the purpose of facilitating A

183 ogic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts.

184 Myod is required for lateral fast muscle differentiation from pax3-expressing cells.

185 18, which are important regulators of smooth muscle differentiation from the mesothelium and related

186 TGF-beta1 promotes the expression of smooth muscle differentiation genes through the inhibition of N

187 interacts with MyoD to enhance expression of muscle differentiation genes.

188 Perturbing the pattern of smooth muscle differentiation genetically or pharmacologically

189 Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however,

190 ve lipid whose signaling activities regulate muscle differentiation, homeostasis, and satellite cell

191 regulation during the initiation of skeletal muscle differentiation; however, there is less informati

192 lts in embryos that lack detectable bodywall muscle differentiation, identifying this trio as a set t

193 he absence of MyoD, was sufficient to induce muscle differentiation in a manner entirely dependent on

194 pidermal growth factor also perturbed smooth muscle differentiation in culture.

195 the GSK3beta inhibitor BIO induced skeletal muscle differentiation in human induced pluripotent stem

196 ures the temporal transcriptional profile of muscle differentiation in mouse C2C12 cells.

197 es MYOD signature genes and induces skeletal muscle differentiation in normal myoblasts and ERMS.

198 nstrate further that Hh ligand drives smooth muscle differentiation in primary intestinal mesenchyme

199 1 kinases to identify those that may repress muscle differentiation in proliferating myoblasts in the

200 ttranslational modification, metabolism, and muscle differentiation in recruited skeletal muscles, wh

201 Here, we examined the role of smooth muscle differentiation in shaping emerging domain branch

202 Notch ligand Jagged1, a key driver of smooth muscle differentiation in the aortic arch arteries.

203 omponent Ezh2 is required to restrict smooth muscle differentiation in the developing lung mesotheliu

204 We conclude that etv2 actively represses muscle differentiation in vascular progenitors, thus res

205 As NAM-NAD(+) biosynthesis also impacts muscle differentiation in vertebrates, we propose that s

206 ing in skeletal muscle to influence skeletal muscle differentiation in vitro and skeletal myofiber si

207 muscle fibers, and knockdown of A20 impairs muscle differentiation in vitro, which suggests that A20

208 SMYD3 methyltransferase coordinates skeletal muscle differentiation in vitro.

209 oss of brown fat characteristics and induces muscle differentiation in vivo through demethylation of

210 s are required for the activation of cardiac muscle differentiation in zebrafish embryos.

211 8 as a key regulator in scube3-mediated fast muscle differentiation in zebrafish.

212 OBEC2 blocks TGFbeta signaling, and promotes muscle differentiation, in a mammalian myoblastic cell l

213 e decreased levels of proteins important for muscle differentiation including pRB, MyoD, desmin, and

214 We show that Pax7 prevents muscle differentiation independently of its transcriptio

215 ing muscle differentiation and implicate two muscle differentiation-induced microRNAs in the process.

216 Muscle differentiation is a complex process in which mus

217 Moreover, follistatin's ability to enhance muscle differentiation is at least partially due to its

218 The Hdac3-dependent block in smooth muscle differentiation is cell autonomous and is associa

219 The role of FoxO3 in regulating muscle differentiation is confirmed in vivo by observed

220 Muscle differentiation is controlled by adhesion and gro

221 Muscle differentiation is further reinforced by positive

222 The complex process of skeletal muscle differentiation is organized by the myogenic regu

223 demonstrate that neural crest-derived smooth muscle differentiation is specifically required for norm

224 a, a malignancy showing features of skeletal muscle differentiation, is the most common soft tissue s

225 vestigate the role of dysferlin during early muscle differentiation, its localization was studied at

226 ckdown of LncMyoD strongly inhibits terminal muscle differentiation, largely due to a failure to exit

227 pathways related to protein ubiquitination, muscle differentiation, lipids and hormonal systems.

228 LMOD3 was expressed from early stages of muscle differentiation; localized to actin thin filament

229 (Epha4, Pmp22, Nrp1, Gap43, Ndn) and smooth muscle differentiation (Madh3, Nrp1, Tagln Calponin, Cal

230 sed in muscle cells and serves as a skeletal muscle differentiation marker.

231 sion along with reduced expression of smooth muscle differentiation markers in the carotids.

232 activity determines the expression of smooth muscle differentiation markers including SMA.

233 lly, revealed by the premature expression of muscle differentiation markers, and, especially, by a re

234 ng SMN inhibited the premature expression of muscle differentiation markers, corrected the cytoskelet

235 entiation, PLA cells were cultured in smooth muscle differentiation medium.

236 During muscle differentiation, mitochondria undergo dramatic ch

237 research groups have used them for skeletal muscle differentiation, most were based on gene over-exp

238 regulates PI3K-AKT, ERK1/2, mTOR signaling, muscle differentiation, myoblast fusion, cellular oxygen

239 During muscle differentiation, myoblasts elongate and fuse into

240 /protein expression of phenotypic markers of muscle differentiation, namely paired box 7 (satellite c

241 nown transcriptional repressors for terminal muscle differentiation, namely ZBTB38, Bhlhe41, and Id1.

242 espite the role played by Msx1 in inhibiting muscle differentiation, nothing is known of the mechanis

243 Remarkably, in the course of muscle differentiation, nuclear movements along the myot

244 of OFT valve primordia by controlling smooth muscle differentiation of cushion NCCs.

245 utive proteasomes, are critical for skeletal muscle differentiation of mouse C2C12 cells.

246 Bmp4 expression, which then enhanced smooth muscle differentiation of neural crest cells (NCCs) in t

247 Thus, we conclude that skeletal muscle differentiation of patient cells causes a higher

248 Smooth muscle differentiation of PLA cells induced genetic expr

249 d Hippo pathways converge to regulate smooth muscle differentiation of the neural crest, which is cru

250 im33 knockdown had no demonstrable effect on muscle differentiation or regeneration.

251 f Mef2 in adult myoblasts leads to premature muscle differentiation, our results explain how and why

252 , coinciding with a reduction in both smooth muscle differentiation potential and TGFbeta1 responsive

253 isrupting this stereotyped pattern of smooth muscle differentiation prevents terminal bifurcation.

254 e a reduction in quantity of ureteral smooth muscle, differentiation proceeded without Smad4, produci

255 lly stable but also biologically relevant to muscle differentiation process.

256 ed role for Myocd in repressing the skeletal muscle differentiation program and suggest that this tra

257 n, our results explain how and why the adult muscle differentiation program is attenuated prior to pu

258 Here we show that the muscle differentiation program is repressed by hypoxia i

259 e for migration and initiation of the smooth muscle differentiation program, however, it is essential

260 ECM expression to act in concert with smooth muscle differentiation program.

261 us role for Ezh2 in repression of the smooth muscle differentiation program.

262 riptional regulation of skeletal and cardiac muscle differentiation programs.

263 se factor (SRF) is a key regulator of smooth muscle differentiation, proliferation, and migration.

264 genes are direct transcriptional targets of muscle differentiation regulators including serum respon

265 normally, but had delayed expression of some muscle differentiation-related genes.

266 stress hormones may be important in skeletal muscle differentiation, repair and regeneration.

267 Skeletal muscle differentiation requires a cascade of transcripti

268 Skeletal muscle differentiation requires precisely coordinated tr

269 Here we demonstrate that MyoD-induced muscle differentiation requires Prmt5.

270 Skeletal muscle differentiation requires the coordinated activity

271 Muscle differentiation requires the transition from moti

272 ion of beta1 integrin at the onset of smooth muscle differentiation resulted in interrupted aortic ar

273 tinct subpopulations of tumor cells based on muscle differentiation status.

274 , bioartificial muscle engineering, skeletal muscle differentiation studies and for better understand

275 n myogenic differentiation using an in vitro muscle differentiation system based on C2C12 cells.

276 Despite compromised muscle differentiation, tendon formation appears unaffec

277 en associated with roles in immune response, muscle differentiation, testes development and DNA damag

278 devastating cancer with specific features of muscle differentiation that can result from mutational a

279 During skeletal muscle differentiation, the activation of some tissue-sp

280 During skeletal muscle differentiation, the actomyosin motor is assemble

281 During muscle differentiation, the inhibition of WNT/beta-caten

282 egulator myocyte enhancer factor 2 (MEF2) in muscle differentiation, the interaction of MEF2 with cof

283 important ubiquitin E3 ligase that modulates muscle differentiation through coordinating cell cycle p

284 Pbx proteins are also necessary for cardiac muscle differentiation through interacting with Hand2.

285 tin E3 ligase UBR5 as an activator of smooth muscle differentiation through its ability to stabilize

286 ar axis, which functionally acts in skeletal muscle differentiation through the modulation of TrxR1 b

287 tive splicing regulator nPTB during skeletal muscle differentiation to control a potential network of

288 us Wnt ligand required for controlling heart muscle differentiation via canonical Wnt/beta-catenin si

289 e repair enzyme TDG as a repressor of smooth muscle differentiation via competing with SRF for bindin

290 In addition, a cell culture system of muscle differentiation was utilized to artificially modu

291 em with reporters of early and late skeletal muscle differentiation, we examined the influence of 2,4

292 criptional targets of MyoD prior to skeletal muscle differentiation, we have undertaken a transcripto

293 Due to their identified roles for terminal muscle differentiation, we hypothesize that the accumula

294 roRNAs (miRNAs) that participate in skeletal muscle differentiation were among the most differentiall

295 r, cell proliferation and NCC-derived smooth muscle differentiation were unaltered.

296 y member ponsin in nascent costameres during muscle differentiation, which is mediated by an interact

297 ional repressor of Myog, inhibiting skeletal muscle differentiation while activating SMC-specific gen

298 During muscle differentiation, while the levels of full-length

299 bility of Notch to promote or inhibit smooth muscle differentiation, while the physiological role for

300 sible and transcription factors that control muscle differentiation, yet we still have only rudimenta