ライフサイエンスコーパス: muscle force

1 ce and those that assess evoked (stimulated) muscle force.

2 accounts for Ca(2+) sensitization of smooth muscle force.

3 eeded to reduce muscle pathology and improve muscle force.

4 to how myosin both generates and responds to muscle force.

5 terminant of physiological levels of passive muscle force.

6 n myosin structure, myosin biochemistry, and muscle force.

7 age-related decreases in DHPR number and in muscle force.

8 to reduced muscle degeneration and improved muscle force.

9 uts with limited bandwidths into an intended muscle force.

10 ivation and completely prevents increases in muscle force.

11 nit forces that sum into the predicted whole muscle force.

12 hich is a key mechanism for the gradation of muscle force.

13 puts into an activation signal that controls muscle force.

14 port movements that require a high degree of muscle force.

15 hondrial proteome is critical for increasing muscle force.

16 cs, and is validated against an experimental muscle force.

17 ly used to transform motoneuronal input into muscle force.

18 clamp method yielded a significantly higher muscle force.

19 s impairs regeneration, leading to decreased muscle force.

20 sistance to muscle fatigue, despite reducing muscle force.

21 biochemistry, and significant enhancement of muscle force.

22 he dystrophin-associated protein complex and muscle force.

23 advances to explain how they could influence muscle force.

24 tor nerve activity served as a surrogate for muscle force.

25 enge, as well as greater decrement in biceps muscle force.

26 uscles determines the magnitude of joint and muscle forces.

27 by a dynamic balance of surface, tissue, and muscle forces.

28 onvert the last neural code of movement into muscle forces.

29 ontrol group, which required less quadriceps muscle forces.

30 rameters required for accurate prediction of muscle forces.

31 ment of new IOLs designed to harness ciliary muscle forces.

32 ATP hydrolysis (ATPase) reaction coupled to muscle force?.

33 macrophage density and a faster recovery in muscle force (20%), combined with an increase in muscle

34 otor deficit characterized by a reduction in muscle force, abnormal muscle contractile characteristic

35 ide a continuous mechanical link to transmit muscle forces across the hypodermis to the cuticle.

36 apted through evolution to complement active muscle forces acting at the same joint.

37 Muscle forces acting on the cranium during chewing and s

38 rate for the first time that the increase in muscle force after 4 weeks of strength training is the r

39 he process of phonation, in which expiratory muscles force air through the tensed vocal folds of the

40 We computed forelimb muscle forces along with force- and length-dependent sen

41 on of motor neurons into types that generate muscle force (alpha motor neurons) and types that modula

42 , joint moments, ground reaction forces, and muscle forces, among others.

43 y shift facilitated a large increase in peak muscle force and an increase in MG power output.

44 muscle generated significantly less absolute muscle force and became more susceptible to contraction-

45 terized by decreased development of skeletal muscle force and cardiac conduction disorders.

46 ULK2 deficiency also led to impaired muscle force and caused myofiber atrophy and degeneratio

47 Arimoclomol significantly improved hindlimb muscle force and contractile characteristics, rescued mo

48 s through both myofiber intrinsic effects on muscle force and downstream fibrosis and extrinsic funct

49 ee sialic acid levels, reduction of skeletal muscle force and endurance, slower healing and smaller s

50 w diet, and it determines the maintenance of muscle force and exercise performance upon a HFD regimen

51 ematically and correlates significantly with muscle force and fatigue.

52 Muscle force and functional capacity generally decrease

53 keletal-troponin complex to calcium improves muscle force and grip strength immediately after adminis

54 survived at least 18 months, and had normal muscle force and intracellular organization of muscle fi

55 tic stage of disease, resulting in increased muscle force and motor unit survival and a significant i

56 rophy (DMD) models but also improve skeletal muscle force and muscle membrane integrity.

57 st cancer, caused remarkable improvements of muscle force and of diaphragm and cardiac structure in t

58 els are expressed on ASM and regulate smooth muscle force and offer a novel target for therapeutic re

59 n (SA), a mechanical property that increases muscle force and oscillatory power generation, is not kn

60 low-level dystrophin expression, we compared muscle force and pathology in mdx3cv and mdx4cv mice.

61 trate that the E525K DCM mutation may reduce muscle force and power by stabilizing the auto-inhibited

62 ponin activator that may be used to increase muscle force and power in conditions of muscle weakness.

63 osed with CK-2066260 show increased hindlimb muscle force and power in response to submaximal rates o

64 As we age, humans see natural decreases in muscle force and power which leads to a slower, less eff

65 efore restoring muscle viability, increasing muscle force and preserving muscle function in dystrophi

66 atment ameliorated histopathology, increased muscle force and protected against eccentric contraction

67 cal conditions in one ALS patient, improving muscle force and respiratory efficacy.

68 ween the rate of actomyosin dissociation and muscle force and shortening velocity.

69 ted the effects of acute nitrite infusion on muscle force and skeletal muscle oxidative metabolism.

70 Our findings suggest that enhanced untrained muscle force and steadiness are mediated by increased re

71 the mean number of attached bridges, depress muscle force and stiffness, and increase force-length hy

72 thetized, tracheotomized rat in which tongue muscle force and the neural drive to the protrudor and r

73 el with the user's calf muscles, off-loading muscle force and thereby reducing the metabolic energy c

74 Regulating muscle force and timing are fundamental for accurate mot

75 e metabolic rates but distinct triceps surae muscle force and velocity demands (walking: low force, h

76 bute substantially to the initial changes in muscle force and work.

77 Principal component analysis was used on 39 muscle forces and 15 3-dimensional joint contact forces

78 Three fDOF were found for the muscle forces and 3-dimensional joint contact forces dur

79 We found that patterns of computed muscle forces and afferent activities were strongly affe

80 re erect limb postures reduces mass-specific muscle forces and bone stresses, it would enable the evo

81 Ross et al. is not only due to variations in muscle forces and cranial morphology, but also due to va

82 supporting an interaction between systematic muscle forces and entheseal morphology.

83 e impact of patient-specific gait pattern on muscle forces and joint loading in individuals with pate

84 ysis, researchers have quantified changes in muscle forces and their effects on palate mechanics duri

85 ed to simulate MU firing rates and isometric muscle forces and, to that model, we added fatigue-relat

86 scaling of firing rates with changes in the muscle force, and (ii) the gains of MU-mode involvement

87 uced an increase in cortical bone volume and muscle force, and a topographic change of cortical thick

88 and organ masses, muscle histology, in vitro muscle force, and creatine kinase levels were measured.

89 lustering, sarcolemmal levels of Nav1.4, and muscle force, and they show no indication of degeneratio

90 amping properties that may aid or oppose the muscle force; and the environment produces reaction forc

91 cular stimuli that initiate these changes in muscle force are not yet fully understood.

92 and grip is a common task during which high muscle forces are sustained, especially at the proximal

93 man skeletal muscles because the majority of muscle forces are transmitted through this region.

94 bed by a muscle equation of state containing muscle force as a state variable.

95 Muscle force assessment in situ after repeated stimulati

96 MuSK or rapsyn ameliorated the acute loss of muscle force associated with strain injury.

97 After assessment of muscle force at days 1, 4, 14, and 42 after injury, samp

98 gested to cause a progressive decline in the muscle force at which motor units are recruited during r

99 This tissue modulates the transfer of muscle forces between two materials, i.e. tendon and bon

100 del of the skull that can be used to predict muscle forces, bite forces, and joint reaction forces wo

101 r that targets the thin filament, to augment muscle force-both in vivo and in vitro-in a nemaline myo

102 d utrophin levels, may help maintain minimal muscle force but not arrest muscle degeneration or necro

103 cycle and contributed almost elastically to muscle force, but the rapidly cycling cross-bridge distr

104 st muscle fatigue and increased mdx hindlimb muscle force by 40%, a value comparable to current dystr

105 t prolapse significantly increases papillary muscle forces by 5% to 15% compared with an optimally co

106 ly but reversible events followed by altered muscle force, calcium dyshomeostasis, and dismantling of

107 ex, upper-extremity function (UEF) test, and muscle force calculations.

108 n an isometric task, where joint torques and muscle forces can be straightforwardly computed from lim

109 tion determines the trajectory of changes in muscle force capacity during prolonged activity.

110 A very large number of possible muscle force combinations will satisfy a particular func

111 s significantly decreased the maintenance of muscle force compared to control.

112 t then level off at modest rates even though muscle force continues to increase.

113 t then level off at modest rates even though muscle force continues to increase.

114 with confidence when model input parameters (muscle forces, detailed material properties) and/or outp

115 Muscle forces determine joint loads, but the objectives

116 Changes in muscle force development as a result of ricin-mAb 35 inj

117 and rate of demembranated (skinned) cardiac muscle force development by exchanging native cardiac tr

118 S; an adapter protein associated with smooth muscle force development) from cytoskeletal vimentin.

119 ion of actin polymerization depresses smooth muscle force development.

120 o diminished actin polymerization and smooth muscle force development.

121 ired for extracellular matrix attachment and muscle force development.

122 nt breeds, taking into account sex, mass and muscle force differences.

123 cessfully prevented chronic exercise-induced muscle force drop.

124 Whole-muscle force drops from peak force production to zero wi

125 Muscle forces during isometric biting appear to be consi

126 However, after nerve crush, reflex muscle forces during stretch do recover after muscle rei

127 mdx-knockout mice exhibited lower muscle force/endurance as well as increased muscle damag

128 study tested the hypothesis that masticatory muscle forces exerted during static biting are consisten

129 timal length), the steady-state value of the muscle force, F, approximates the isometric force, the m

130 easured extensor digitorum longus and soleus muscle forces, fatigue, and contractile kinetics in vitr

131 k(1) in a curl force field that elicited new muscle forces for some, but not all, movement directions

132 quencies of these oscillations are above the muscle force frequency range.

133 e depends on the transmission of contractile muscle forces from tendon to bone across the enthesis.

134 ase phenotype and significant improvement in muscle force (from 11 mN/mg to nearly 16 mN/mg).

135 coupling deficits, we compared the papillary muscle force generated by electrically stimulated versus

136 en deprivation did not prevent preserve limb muscle force generating capacity.

137 Strikingly, the assessment of skeletal muscle force-generating capacity ex vivo revealed that m

138 es a myopathy characterized by reductions in muscle force-generating capacity, atrophy (loss of muscl

139 -I, there were significant increases both in muscle force generation and cross-sectional area at all

140 le MR deficiency led to improved respiratory muscle force generation and less deleterious fibrosis bu

141 that neither mitochondrial respiration, nor muscle force generation are affected by acute increased

142 Reldesemtiv demonstrated increased muscle force generation in a phase 1 clinical trial and

143 and aging by directly determining changes in muscle force generation in active laboratory mice.

144 ificantly increased cross-sectional area and muscle force generation lasting over 3 months.

145 We also found that muscle force generation was protected with CMD treatment

146 ance were independent of central command and muscle force generation, were not activated in anticipat

147 cross-sectional area and decreased skeletal muscle force generation.

148 that an endothermic molecular step underlies muscle force generation.

149 apidly improved in movement acceleration and muscle force generation.

150 cal mechanisms of muscle work production and muscle force generation.

151 frame deletion show defective locomotion and muscle force generation.

152 ine kinase levels, but had limited effect on muscle force generation.

153 uscular transmission and faithfully reported muscle force generation.

154 seem to impair the ability to control trunk muscle force, however, perceived soreness induced change

155 les, taking into consideration surrogates of muscle force [ie, muscle cross-sectional area (MCSA) and

156 mRNA and protein levels in muscle and rescue muscle force in Dnm2R369W/+ mice, suggesting a promising

157 or, improved muscle relaxation and increased muscle force in HSALR mice without affecting splicing.

158 ration, and reduces exercise performance and muscle force in mice.

159 loskeletal transformation increased fore-aft muscle force in neognaths, enabling powered cranial kine

160 The specific single twitch and tetanic muscle force in old transgenic soleus and extensor digit

161 that CK-2017357 increases the production of muscle force in situ at sub-maximal nerve stimulation ra

162 s viability of the limb but fails to restore muscle force in the long term.

163 imulations by comparing the timing of active muscle forces in our baseline simulation to timing in ex

164 Masticatory muscle forces influence craniofacial morphology developm

165 sease symptomology that causes resistance in muscle force initiation.

166 ads, but the objectives governing the mix of muscle forces involved are unknown.

167 Variability in muscle force is a hallmark of healthy and pathological h

168 n equilibrium between agonist and antagonist muscle force is achieved.

169 Our results show that muscle force is associated with a transition of the cros

170 Muscle force is dictated by micrometer-scale contractile

171 We propose that striated muscle force is generated by a singular, mesh-like myofi

172 Muscle force is generated by myosin crossbridges interac

173 erefore, quantitative assessment of skeletal muscle force is important for diagnosis of intensive car

174 Thus, the temperature sensitivity of muscle force is markedly increased with velocity during

175 The question of whether complicated muscle forcing is required to create the observed deform

176 directly measured subject specific gracilis muscle force-length relationship in situ and properties

177 alis; in particular, motoneuronal inputs and muscle force levels are chosen to approximately achieve

178 relationship between prolapse and papillary muscle forces, leveraging advances in ex vivo modeling a

179 musculoskeletal and finite element approach, muscle forces, ligament stresses, and articular cartilag

180 ryngeal muscle, small body size, and reduced muscle force, likely due to poor nutritional uptake.

181 meters provide a mechanistic explanation for muscle force loss after EC.

182 ons lead to severe side-effects and weakened muscle force, making them incompatible with activity-bas

183 In addition, muscle force measured after exercise decreases upon HFD

184 diaphragm strip to the clamp and then to the muscle force measurement system.

185 At 12 weeks, electromyography and muscle force measurements (maximum twitch and tetanic fo

186 tor activity, histopathology, and individual muscle force measurements of mdx and mdx((5)cv) mice.

187 ence of changes in convective O(2) delivery, muscle force, muscle contractile economy and mitochondri

188 plasma nitrite concentration affects neither muscle force, nor muscle contractile economy.

189 ither provide resistance against extraocular muscle forces or limit globe axial elongation.

190 x (M1): relatively low-level parameters like muscle force, or more abstract parameters like handpath?

191 al descriptions of the relationships between muscle force output and shortening velocity and between

192 ed an acute 27% reduction in directly evoked muscle force output, affirming the susceptibility of mdx

193 ge based upon motor unit discharge rates and muscle force output.

194 tates of a key behavior produce asymmetry in muscle forces, passive joint forces can be coadapted to

195 on the relative impact of these variables on muscle force performance of engineered muscle constructs

196 mpt)) leading to a hypermuscular yet reduced muscle-force phenotype was compared to that in wild-type

197 orylation plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but no

198 tal issue in locomotion is to understand how muscle forcing produces apparently complex deformation k

199 specific GSK3 knockdown in mdx mice augments muscle force production and endurance.

200 Mice with CKD displayed lower muscle force production and greater ischemic lesions in

201 uscle quality, identifiable by reductions in muscle force production and mitochondrial respiratory ca

202 s of augmented nitric oxide (NO) on skeletal muscle force production and oxygen consumption ( VO2 ).

203 forelimb muscles contribute substantially to muscle force production and proprioceptive activity, to

204 of events that contribute to reduced smooth muscle force production during altered metabolism.

205 e data suggest that NRF2 activation improves muscle force production during ambulatory conditions but

206 at SOCE, peak Ca(2+) transient amplitude and muscle force production during repetitive stimulation ar

207 e effects of OM on cross-bridge kinetics and muscle force production have been conducted at subphysio

208 whether and to what extent 4AP could enhance muscle force production in HCSMA.

209 In addition, muscle force production in isometric contraction was inc

210 on specific molecular mechanisms involved in muscle force production in mice and skinned permeabilize

211 icle-shortening velocity at the time of peak muscle force production increased with walking speed, im

212 Skeletal muscle force production is increased at longer compared

213 future investigations and models of skeletal muscle force production must incorporate Tmods.

214 rcise on SOCE, constitutive Ca(2+) entry and muscle force production were lost in mice with muscle-sp

215 zed expression of NMJ-related genes, in situ muscle force production, and clearance of glycogen in co

216 e model regarding the possibility of maximal muscle force production, and suggest that only 97% of th

217 appreciated cost proportional to the rate of muscle force production, for calcium transport to activa

218 nt also reduced muscle fibrosis and enhanced muscle force production, including in the diaphragm musc

219 With no effect on muscle force production, inhibiting alphaARs (phentolami

220 With no effect on muscle force production, inhibiting alphaARs improved RO

221 cted tissue and modify AChR mRNA expression, muscle force production, motor endplate area, and innerv

222 mically modulate stiffness along the axis of muscle force production.

223 ge translated into a significant increase in muscle force production.

224 mprovement in forelimb grip strength or limb muscle force production.

225 decreased muscle and body mass, and impaired muscle force production.

226 muscle weakness by decreasing Ca(2+)-induced muscle force production.

227 taking into account the state dependence of muscle-force production and multijoint mechanics, I show

228 e and number of nuclear aggregates, improves muscle force, protects myofibers from the pathology-deri

229 stress we predict working to balancing side muscle force ratios, peak bite forces, and joint reactio

230 assive muscle fire in direct relationship to muscle force-related variables, rather than length-relat

231 Lower quadriceps muscle forces resulted in a reduction of tibiofemoral an

232 ice are of a size at which passive joint and muscle forces should be important in leg movements.

233 Muscle force studies showed more severe strength deficit

234 o-CT, histomorphometrics, OARSI scoring, and muscle force testing were performed on samples.

235 stimating or measuring the joint torques and muscle forces that underlie movements made by biological

236 This intervention led to a rescue of muscle force, thereby preventing disease progression.

237 factors regulate and/or maintain extraocular muscle force through a rapid mechanism that appears to i

238 sibly through more efficient transmission of muscle force through stiffer intestinal tissue.

239 nematics, improved similarity between active muscle force timing and experimental electromyography, a

240 rom contraction-induced injury and corrected muscle force to the same level as that observed in contr

241 a indicates a transition from a dominance of muscle forces to a dominance of inertial forces as anima

242 igaments called zonules that mediate ciliary muscle forces to alter lens shape.

243 ncounter challenges in generating sufficient muscle forces to support their bodies and maintain bone

244 s are dense connective tissues that transmit muscle forces to the skeleton.

245 This enhanced the diaphragm muscle force, to a greater extent with lower lung volume

246 dynamic parameters of jaw function including muscle force, torque, effective mechanical advantage, ja

247 We developed an ex vivo papillary muscle force transduction and novel neochord length adju

248 plasmic reticulum Ca(2+) release and maximal muscle force unchanged.

249 del by uniformly reducing the peak isometric muscle force unilaterally.

250 For molecular motors and for muscle, force-velocity curves have provided key biophysi

251 Net tongue muscle force was always consistent with tongue retractio

252 wisdom, is based in part on studies in which muscle force was shown to decline more rapidly when stim

253 evoked compound muscle action potentials and muscle force were also diminished.

254 week after injection, muscle morphology and muscle force were compared between the IGF-treated and c

255 tion leads to significantly higher papillary muscle forces, which could be a possible trigger for cel

256 To accelerate, they must produce higher muscle forces, which leads to higher reaction forces bac

257 n, systolic blood pressure, and LV papillary muscle force while LV end-diastolic and systolic volume

258 and its 'signal dependence' (variability in muscle force whose amplitude increases with intensity of

259 model reproduced previously published output muscle forces with an average error of 0.0435 N.

260 Muscular Dystrophy is sufficient to improve muscle force without any increase in mitochondrial conte

261 ing, and calculations of how quickly passive muscle force would slow limb movement as limb size varie

262 model output appears to 'encode' aspects of muscle force, yank, length, stiffness, velocity, and/or