ライフサイエンスコーパス: muscle mass

1 cently identified as a positive regulator of muscle mass).

2 m 1 oxygen sensor in mice (PHD1(KO)) reduces muscle mass.

3 le body fat mass percentage and index of low muscle mass.

4 ctor 1 (IGF1) is a key positive regulator of muscle mass.

5 , and this leads to only a small increase in muscle mass.

6 this ligand as a negative regulator of adult muscle mass.

7 o be the best performer in the estimation of muscle mass.

8 ) protein BRD4 as an epigenetic regulator of muscle mass.

9 ating inquiries into molecular regulation of muscle mass.

10 aracterized by reductions in peripheral lean muscle mass.

11 essive mitochondrial dysfunction and loss of muscle mass.

12 splice variant PGC1alpha4 increase skeletal muscle mass.

13 1 are potent negative regulators of skeletal muscle mass.

14 protein could also be important enhancers of muscle mass.

15 y member, and negative regulator of skeletal muscle mass.

16 resistance exercise, promote an increase in muscle mass.

17 cephalopathy through an increase in skeletal muscle mass.

18 ed with increased body weight, bone size and muscle mass.

19 hat SNARK may function in the maintenance of muscle mass.

20 n-6 and MCP-1 levels, and decreased skeletal muscle mass.

21 Myostatin is a negative regulator of muscle mass.

22 .007] were independent predictors of reduced muscle mass.

23 emale gravidity and increased male hind limb muscle mass.

24 the cPLA(2) pathway contributing to loss of muscle mass.

25 ional capacity in patients with COPD and low muscle mass.

26 limb force proportionally to the increase in muscle mass.

27 for at least 1 month, even after recovery of muscle mass.

28 acid supplementation in tn mutants improves muscle mass.

29 riptional and translation output and restore muscle mass.

30 n of patients also have poor fitness and low muscle mass.

31 bility (+ 22%), heart rate (- 1.1%) and lean muscle mass (+ 1.4%)] and cognitive function [(episodic

32 iency (+ 1.8%), heart rate (- 2.4%) and lean muscle mass (+ 1.5%).

33 in vitro Unexpectedly, a marked decrease in muscle mass (10%) was found after Alk4 AON treatment in

34 +/- 6 mg, p = 0.04) along with the ratio of muscle mass (+3 +/- 1% vs. -1 +/- 1% p = 0.04).

35 were observed: decreased accrual of skeletal muscle mass after weaning and reduced wheel-running acti

36 deletion of Pak1 and Pak2 results in reduced muscle mass and a higher proportion of myofibers with a

37 restricted increases in peribronchial smooth muscle mass and accumulation of lung collagen, primary f

38 PERK regulates skeletal muscle mass and contractile function in adult mice.

39 hereas Panx1(Deltaot) males showed unchanged muscle mass and decreased in vivo maximum plantarflexion

40 ass, improved grip strength, higher skeletal muscle mass and diameter, and an increase in type 2 fibe

41 a, as determined by observing an increase in muscle mass and fiber type cross-sectional area in selec

42 ve mechanical loading attenuates the loss of muscle mass and force-generation capacity associated wit

43 significantly to the age-related decline in muscle mass and function (sarcopenia).

44 nhibition would improve recovery of skeletal muscle mass and function after cerebral ischemia.

45 lated oxidative damage or rescue the loss of muscle mass and function associated with aging of skelet

46 ave been used in clinical trials to increase muscle mass and function but most showed limited efficac

47 is essential for the maintenance of skeletal muscle mass and function in adult mice.

48 arm of the UPR in the regulation of skeletal muscle mass and function in naive conditions and in a mo

49 Physical inactivity triggers a rapid loss of muscle mass and function in older adults.

50 abolism in the pathological loss of skeletal muscle mass and function in older people.

51 of anorexia, leading to reduced adipose and muscle mass and function in tumor-bearing mice.

52 myostatin activation, effectively increases muscle mass and function in two variants of the pharmaco

53 RATIONALE: Loss of skeletal muscle mass and function is a common consequence of crit

54 Age-related loss of skeletal muscle mass and function is a key contributor to physica

55 Age-related loss of skeletal muscle mass and function is a major contributor to morbi

56 copenic obesity, the combination of skeletal muscle mass and function loss with an increase in body f

57 Loss of skeletal muscle mass and function occurs with increasing age.

58 timately contributes to the systemic loss of muscle mass and function termed sarcopenia.

59 e disorder involving the accelerated loss of muscle mass and function that is associated with increas

60 icial effects of metallothionein blockade on muscle mass and function was also observed in the settin

61 estigated the effects on age-related loss of muscle mass and function, changes in redox homeostasis,

62 In addition to impairing muscle mass and function, Folfiri had severe negative ef

63 Loss of muscle mass and function, or sarcopenia, is a common fea

64 bstrates, is instrumental for maintenance of muscle mass and function.

65 with age, with significant consequences for muscle mass and function.

66 ission precede a clinically-relevant loss of muscle mass and function.

67 nts with severe COPD by enhancing quadriceps muscle mass and function.

68 progressive and generalized loss of skeletal muscle mass and function.

69 tiate rapid and significant loss of skeletal muscle mass and function.

70 aralysis, or bed rest leads to rapid loss of muscle mass and function; however, the molecular mechani

71 and its down-regulation is linked to reduced muscle mass and functional decline.

72 umor-bearing mice exhibited reduced body and muscle mass and impaired grip strength compared with con

73 knockout in mice blocks CKD-induced loss of muscle mass and improves protein synthesis.

74 in airway remodeling, with increased smooth muscle mass and increased fibrosis in the absence of air

75 isk of type 2 diabetes (T2D), maintenance of muscle mass and increased metabolic capacity.

76 Loss of muscle mass and insulin sensitivity are common phenotypi

77 However, creatinine is a product of muscle mass and is therefore associated with body mass.

78 tration and significantly increased skeletal muscle mass and lean body mass over time.

79 d no significant difference in both skeletal muscle mass and lean body mass.

80 k of bed rest substantially reduces skeletal muscle mass and lowers whole-body insulin sensitivity, w

81 In contrast, reductions in both skeletal muscle mass and Mito(VD) have been reported following mo

82 regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes.

83 Sarcopenia (AWGS) criteria that include both muscle mass and muscle function/physical activity.

84 statin antibody (ATA 842) for 4 wk increased muscle mass and muscle strength in both groups.

85 sarcopenic characteristics, including a low muscle mass and muscle strength.

86 Loss of skeletal muscle mass and muscle weakness are common in a variety

87 Muscle mass and myofiber area were decreased 20-30% in S

88 14 days of age that consists of reduced body/muscle mass and myofibre hypotrophy.

89 Lipin1 deficiency induced reduced muscle mass and myopathy.

90 biomarkers and evaluate its association with muscle mass and patient outcomes.

91 , or supplements containing HMB, on skeletal muscle mass and physical function in a variety of clinic

92 RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly men.In this

93 understanding of the maintenance of skeletal muscle mass and prevention of muscle atrophy by epigenet

94 tor 2B signaling, has been shown to preserve muscle mass and prolong survival in tumor hosts, and to

95 to be one of the important causes of loss of muscle mass and quality of life in elderly adults.

96 global and regional contractility, increased muscle mass and reduced scar size.

97 nonmetastatic CRC, with great variability in muscle mass and SMD across age, TAT, and race/ethnicity.

98 hways are essential for maintaining skeletal muscle mass and strength and for protection against canc

99 The causes of impaired skeletal muscle mass and strength during aging are well-studied i

100 Sarcopenia, the loss of muscle mass and strength during normal aging, involves c

101 B, and supplements containing HMB, increased muscle mass and strength in a variety of clinical condit

102 have been shown to inversely correlate with muscle mass and strength in elderly people especially wi

103 ation of MyD88 inhibits the loss of skeletal muscle mass and strength in LLC tumor-bearing mice.

104 KEY POINTS: Loss of muscle mass and strength in the growing population of el

105 dent total RNA accumulation and increases in muscle mass and strength point to ribosome biogenesis as

106 strikingly decreased adiposity with complete muscle mass and strength retention.

107 The maintenance of skeletal muscle mass and strength throughout life is a key determ

108 rategies for preventing declines in skeletal muscle mass and strength with age.

109 There is a gradual loss of both skeletal muscle mass and strength with ageing (a process termed s

110 ACVR2B/Fc prevented the loss of muscle mass and strength, and the loss of trabecular bon

111 omoted to augment the effects of exercise on muscle mass and strength, but their effectiveness in mid

112 disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapacity

113 se in C26 oxfu mice counteracted the loss of muscle mass and strength, partially rescuing autophagy a

114 ogravity exposure is associated with loss of muscle mass and strength.

115 erformed to evaluate the association between muscle mass and the covariates over time.

116 Lower limb muscle mass and the stimulated limb to non-stimulated li

117 of E2F results in a significant reduction in muscle mass and thinner myofibrils.

118 conditions characterized by loss of skeletal muscle mass and weakness.

119 nsequently, Skm-CB1R(-/-) mice had increased muscle mass and whole-body lean/fat ratio in obesity and

120 pinning this finding, such as a low skeletal muscle mass and/or fluid overload.

121 (T2(water)) as markers for fat infiltration, muscle mass, and alteration in tissue water distribution

122 ecretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation.

123 maximum tetanic tension, decreased tibialis muscle mass, and fiber diameter due to inflammation alon

124 muscle in control of insulin sensitivity and muscle mass, and has a unique role in mitochondrial home

125 nicotinic acetylcholine receptor expression, muscle mass, and histologic changes (structural paramete

126 s another family member negatively regulates muscle mass, and its blockade enhances muscle growth see

127 ce of favoring lipid metabolism, maintaining muscle mass, and reducing apoptotic susceptibility over

128 activin A as a second negative regulator of muscle mass, and suggest that inhibition of both ligands

129 Inhibition of myostatin signaling increases muscle mass, and therapeutic approaches based on this ar

130 e/degenerative status of the muscle, overall muscle mass, and tissue expression levels.

131 muscle index (SMI), a surrogate of skeletal muscle mass, and to evaluate the skeletal muscle density

132 yostatin induced a more profound increase in muscle mass ( approximately 45%), demonstrating a more p

133 extracellular matrix (ECM) and larger smooth muscle mass are correlated with increased airway respons

134 Bone and skeletal muscle mass are highly correlated in mammals, suggesting

135 Here, we firstly report that bone and muscle mass are regulated by the gravity with loaded for

136 arcopenia, the ideal timing and frequency of muscle mass assessment, and how to best incorporate the

137 ed to prevent age-dependent loss of skeletal muscle mass associated with myofiber atrophy or alter a

138 racterized by a progressive loss of skeletal muscle mass associated with significant functional impai

139 emographic, tumor, and treatment factors and muscle mass at diagnosis.

140 TRB3 has the potential to regulate skeletal muscle mass at the basal state.

141 stronger effect in preventing aging-related muscle mass attenuation and leg strength loss in older p

142 de decreased body and facial hair, decreased muscle mass, breast growth, and redistribution of fat.

143 magrumab treatment safely increased skeletal muscle mass but did not improve functional capacity in p

144 mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrie

145 Age and sex interactions were noted for muscle mass, but not SMD.

146 dipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation or increa

147 a mechanically induced increase in skeletal muscle mass, but the mechanism(s) through which mechanic

148 ls play a critical role in the regulation of muscle mass, but the molecules that sense mechanical sig

149 etary protein was positively associated with muscle mass, but the relation of this distribution to ph

150 AV vector) expressing the beta2-AR increased muscle mass by >20% within 4 weeks.

151 uggest a novel role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factor

152 ceptors (ALK4 and ALK5) in the regulation of muscle mass by these ligands by genetically targeting th

153 ation for 48 h in mice significantly reduces muscle mass by ~15% and increases TRB3 expression, which

154 hic (CT) metrics of bone mineral density and muscle mass can improve the prediction of noncancer deat

155 was down-regulated in adult wild-type mice, muscle mass decreased even more.

156 Immobilization-induced loss of tibialis muscle mass, decreased fiber diameter, and tetanic fade

157 Skeletal muscle mass decreases in end-stage heart failure and is

158 Genetic variability substantially influences muscle mass differences, but causative genes remain larg

159 Low muscle mass, due to fewer and/or smaller constituent mus

160 gher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the ri

161 The sarcopenia index is a fair measure for muscle mass estimation among ICU patients and can modest

162 rovement in TA muscle morphology and gain in muscle mass evident in the WT mice was not noticeable in

163 perfusion during high intensity and/or large muscle mass exercise in older adults.

164 al ventilation) are minimized by using small muscle mass exercise.

165 atures of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fib

166 and immobilization, the decrease in tibialis muscle mass, fiber diameter, and maximum tetanic tension

167 Many factors contribute to the erosion of muscle mass following burn trauma and we propose that an

168 Many factors contribute to the erosion of muscle mass following burn trauma, and we have previousl

169 pericytes effectively rehabilitate skeletal muscle mass following disuse atrophy.

170 C3KO) resulted in 1.5- to 2-fold increase of muscle mass for the majority of limb muscles.

171 resumed habitual physical activity, restored muscle mass from a reduction of 51% after 14 d TTX to a

172 gnificant increase in UBR5 after recovery of muscle mass from hindlimb unloading in both adult and ag

173 er survival, GTx-026 treatment increased the muscle mass, function and survival, indicating that andr

174 ut rather they mediate host regeneration and muscle mass gain in a paracrine manner.

175 g has been shown to be required for skeletal muscle mass gains in some models of hypertrophy.

176 ABSTRACT: Significant skeletal muscle mass guarantees functional wellbeing and is impor

177 A decrease in skeletal muscle mass has been shown to increase hospital mortalit

178 ed in statistically significant increases in muscle mass; however, functional testing did not reveal

179 eletal muscle is a key regulator of skeletal muscle mass; however, it is unclear whether nNOS express

180 sty, a new technique to reduce airway smooth muscle mass, improves symptoms and reduces exacerbations

181 The relation between muscle mass in advanced age and telomere length, however

182 erhaps due to divergent selection for higher muscle mass in archaic hominins compared with humans.

183 ys have, however, largely failed to preserve muscle mass in cachexia, suggesting that other mechanism

184 TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy.

185 s a conserved negative regulator of skeletal muscle mass in mammals.

186 been shown to underlie the loss of skeletal muscle mass in many acquired and genetic muscle disorder

187 ER stress and UPR in regulation of skeletal muscle mass in naive conditions and during cancer cachex

188 re modifiable factors associated with higher muscle mass in older adults but not with losses over 2 y

189 anistically, the better recovery of skeletal muscle mass in PINTA745-MCAO mice involved an increased

190 imed to evaluate whether progressive loss of muscle mass in septic shock patients was associated with

191 ght novel methods for potentially modulating muscle mass in settings of disease.

192 ABSTRACT: Reduced skeletal muscle mass in the fetus with intrauterine growth restri

193 tivated transcriptional profiles to increase muscle mass in wild type and R6/2 mice but did little to

194 statin deficiency (Mstn(tm1Sjl/+)) increases muscle mass in wild-type offspring, suggesting an intrau

195 s bone mass in young and old female mice and muscle mass in young female mice, but has deleterious ef

196 a primary muscle weakness (without a loss of muscle mass) in patients with mild cognitive impairment,

197 After training, muscle mass increased in NMES vs. sham (416 +/- 6 vs. 39

198 induced a synergistic response, resulting in muscle mass increasing by as much as 150%.

199 index < 20 kg/m(2) or appendicular skeletal muscle mass index <= 7.25 [men] and <= 5.67 [women] kg/m

200 ons - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and European Working Group on Sa

201 lated body fat percentage (%BF) and skeletal muscle mass index (SMI).

202 graphy data available, unilateral pectoralis muscle mass indexed to body surface area and attenuation

203 odel of in-vivo non-invasive chronic NMES on muscle mass, insulin sensitivity and arterial blood pres

204 Although it is clear that muscle mass is an important predictor of LT outcomes, ma

205 Age-related progressive loss of muscle mass is an increasing problem in our aging societ

206 The maintenance of skeletal muscle mass is critical for sustaining health; however,

207 The amount of muscle mass is determined by coordinated changes in musc

208 ABSTRACT: The maintenance of skeletal muscle mass is essential for health and quality of life.

209 Thus, a novel approach toward recovery of muscle mass is highly desired.

210 Low muscle mass is present in approximately 40% of patients

211 enesis is unclear, although increased smooth muscle mass is present.

212 Skeletal muscle mass is regulated by the coordinated activation o

213 ammonia restores proteostasis and increases muscle mass is unknown.

214 ion of skeletal muscle protein synthesis and muscle mass, it does not appear to be a prerequisite for

215 openia, a progressive age-associated loss of muscle mass, leading to a decline in mobility and qualit

216 In stroke patients, loss of skeletal muscle mass leads to prolonged weakness and less efficie

217 To conclude, whilst muscle mass loss and insulin resistance are common end-p

218 tempted to elucidate molecular regulators of muscle mass loss and insulin resistance during increased

219 increased fat deposition without significant muscle mass loss at 16 wk of age.

220 e protein synthesis is the primary driver of muscle mass loss in human immobilisation, and includes b

221 Muscle mass maintenance is largely regulated by basal mu

222 Our study suggested that progressive loss of muscle mass might be a useful prognostic factor for sept

223 is sustainable as well as how improvement in muscle mass might be associated with improvement in clin

224 n understudied human populations, as well as muscle mass, milk production, and tameness in specific b

225 scle depletion is characterized by a reduced muscle mass (myopenia) and increased infiltration by int

226 l performance (n = 24) were more common than muscle mass (n = 8).

227 Although a gradual loss of muscle mass normally occurs with advancing age, its incr

228 e also conducted a GWAS on hindlimb skeletal muscle mass of 1,867 mice from an advanced intercross be

229 mon peroneal nerve-resulted in reductions in muscle mass of 7, 29, and 51% with corresponding reducti

230 /+) mice, NOD TLR4(-/-) animals showed lower muscle mass of the small intestine, higher abundance of

231 The main adductor and abductor muscles masses of the pectoral system are completely div

232 bition of myostatin, a negative regulator of muscle mass, offers a promising approach to increase mus

233 fore, PGC1beta activation negatively affects muscle mass over time, particularly fast-twitch muscles,

234 (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution of fat (P

235 ed muscles, and SIRT1 levels correlated with muscle mass, paired box protein 7 (Pax7), proliferating

236 the factors that regulate the size of human muscle mass, particularly during the later years of life

237 Furthermore, after recovery of muscle mass post TTX-induced atrophy in rats, UBR5 was h

238 at PGC1beta progressively decreases skeletal muscle mass predominantly associated with loss of type 2

239 wever, PAX7+ cells are detected in remaining muscle masses present in the epaxial region of the doubl

240 ining resulted in significantly increases of muscle mass, protein synthesis (puromycin incorporation

241 produced significant increases in body mass, muscle mass, quadriceps myofiber size, and survival, but

242 isons between number of muscle deficits (low muscle mass, quadriceps strength and physical performanc

243 d the stimulated limb to non-stimulated limb muscle mass ratio were compared between groups (NMES vs.

244 Muscle mass reconstitution did not correlate with resolu

245 Aging is associated with diminished muscle mass, reductions in muscle stem cell functions, a

246 s pathogenetic molecular pathways related to muscle mass regulation in CKD mice.

247 e that TRB3 plays a pivotal role in skeletal muscle mass regulation under food deprivation-induced mu

248 autonomous role the VDR has within skeletal muscle mass regulation.

249 us into the biochemical events that regulate muscle mass remain ill-defined.

250 rms of the UPR in the regulation of skeletal muscle mass remain largely unknown.

251 phosphorylation) that drive the increase in muscle mass remain undefined.

252 are surrogates for bone mineral density and muscle mass, respectively, were independent predictors o

253 d minor atrophic and hypertrophic changes in muscle mass, respectively.

254 What is the relationship between low muscle mass (sarcopenia) or sarcopenic obesity and cance

255 as having at least two of the following: low muscle mass, self-reported exhaustion, low energy expend

256 sufficient to cause significant increases in muscle mass, showing that myofibers are the direct targe

257 in hypertrophy and negatively correlate with muscle mass, SIRT1 and Nampt levels.

258 Percentages of body fat (BF) and skeletal muscle mass (SM) were calculated using validated formula

259 ments containing HMB, on increasing skeletal muscle mass (SMD = 0.25; 95% CI: -0.00, 0.50; z = 1.93;

260 tablished sarcopenia definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and

261 ms were to characterize deficits in skeletal muscle mass, strength and physical performance, and exam

262 r a small-molecule inhibitor, increased aged muscle mass, strength, and exercise performance.

263 inducible deletion of PERK reduces skeletal muscle mass, strength, and force production during isome

264 progressive and generalized loss of skeletal muscle mass, strength, and function.

265 progressive and generalized loss of skeletal muscle mass, strength, and function.

266 ized controlled trials reporting outcomes of muscle mass, strength, and physical function was perform

267 ining (RT) has shown to mitigate the loss of muscle mass, strength, improve inflammatory profiles, an

268 benefits in the primary outcome measures of muscle mass, strength, or cognitive function compared to

269 f 4.1 to 1, demonstrating greater thrust per muscle mass than typical biological counterparts(6).

270 and disuse are associated with reductions in muscle mass that are in part attributable to dysregulati

271 erine growth restriction (IUGR) have reduced muscle mass that persists postnatally, which may contrib

272 uterine growth restriction (IUGR) have lower muscle mass that persists postnatally.

273 MIGIRKO mice displayed a marked reduction in muscle mass that was linked to increases in proteasomal

274 n, including the best modality for assessing muscle mass, the optimal cut-off values for sarcopenia,

275 ough endurance-based exercise) and increased muscle mass (through resistance-based exercise), typical

276 Returning muscle mass to levels observed at 7 d TTX administration

277 1), a well-established positive modulator of muscle mass, to be surprisingly hyperactivated in sarcop

278 een explored whether TRB3 regulates skeletal muscle mass under atrophic conditions.

279 vely evaluated for skeletal muscle deficits: muscle mass using bioelectrical impedance, quadriceps, r

280 values of fat mass and appendicular skeletal muscle mass utilizing the LMS statistical procedure.

281 these findings shed light on the genetics of muscle mass variability in humans and identify targets f

282 s type 2 (ILCs), and increased airway smooth muscle mass via recruitment of mesenchymal progenitors t

283 -beta proteins to the negative regulation of muscle mass via their activation of the Smad2/3 signalin

284 correlation (r) between sarcopenia index and muscle mass was 0.62 and coefficient of determination (r

285 imb force and maximal speed, while their leg muscle mass was diminished, with a lower number of type

286 sed with a handgrip dynamometer and skeletal muscle mass was estimated using bioelectrical impedance.

287 In the retrospective cohort, muscle mass was estimated using pectoralis muscle area i

288 The gold standard for muscle mass was quantified with the paraspinal muscle su

289 tin, a master negative regulator of skeletal muscle mass, was strongly increased in skeletal muscle i

290 otein requirements, particularly to maintain muscle mass.We investigated whether controlled protein c

291 IR-/- mice displayed a moderate reduction in muscle mass whereas M-IGF1R-/- mice did not.

292 the VDR in the regulation of myogenesis and muscle mass, whereby it acts to maintain muscle mitochon

293 activins are negative regulators of skeletal muscle mass, which have been reported to primarily signa

294 restriction (IUGR) suffer from reductions in muscle mass, which may contribute to insulin resistance

295 uscle ablation resulted in a 40% increase in muscle mass, which was associated with a significant inc

296 K in myocyte survival and the maintenance of muscle mass with age.

297 roduced 2G hypergravity on mice for bone and muscle mass with newly developed centrifuge device.

298 reases muscle protein synthesis acutely, and muscle mass with training, but the role of translational

299 ale Panx1-deficient mice exhibited increased muscle mass without changes in strength, whereas Panx1(D

300 d increased autophagy and completely rescued muscle mass without changing proteasomal activity.