ライフサイエンスコーパス: muscle regeneration

1 atrophy, sarcolemmal fragility, and impaired muscle regeneration.

2 AMPKalpha1 in satellite cell activation and muscle regeneration.

3 d4 in aged SCs did not promote aged skeletal muscle regeneration.

4 their deficits in Treg cell accumulation and muscle regeneration.

5 uring SC differentiation, and it potentiates muscle regeneration.

6 roves the myopathy phenotype is by promoting muscle regeneration.

7 peded satellite cell activation and impaired muscle regeneration.

8 peutic potential to improve in situ skeletal muscle regeneration.

9 active H3K27 demethylation is necessary for muscle regeneration.

10 Smad4 disruption compromised adult skeletal muscle regeneration.

11 ed by many complications, including impaired muscle regeneration.

12 ll deficit which unexpectedly did not affect muscle regeneration.

13 oRNAs (miR-1 and -206) to further accelerate muscle regeneration.

14 utation also resulted in functional striatal muscle regeneration.

15 ich is required for satellite activation and muscle regeneration.

16 ibits cardiomyocyte proliferation and delays muscle regeneration.

17 lanted into host mouse muscles contribute to muscle regeneration.

18 ifferentiation and reduces the efficiency of muscle regeneration.

19 ces myogenic differentiation and accelerates muscle regeneration.

20 tivation and myogenic differentiation during muscle regeneration.

21 de skeletal muscle and are indispensable for muscle regeneration.

22 f the MEF2A transcription factor in skeletal muscle regeneration.

23 ty to resume proliferation and contribute to muscle regeneration.

24 ned whether lipin1 contributes to regulating muscle regeneration.

25 f Rbfox1 in satellite cells does not disrupt muscle regeneration.

26 and molecular mechanisms underlying skeletal muscle regeneration.

27 tem cell, or satellite cell, is required for muscle regeneration.

28 FGFR4 is involved in myogenesis and muscle regeneration.

29 sed levels of whole muscle N1ICD and limited muscle regeneration.

30 AT2R antagonist PD123319 during CTX-induced muscle regeneration.

31 at Nrf2-deficient mice therefore have poorer muscle regeneration.

32 eletion of SAM in SCs leads to deficiency in muscle regeneration.

33 f macrophage/monocyte subsets is critical to muscle regeneration.

34 ndent transcriptome associated with skeletal muscle regeneration.

35 recovery of hindlimb perfusion and superior muscle regeneration.

36 e in regulating myoblast differentiation and muscle regeneration.

37 in satellite cells during acute and chronic muscle regeneration.

38 oves the efficacy of the transplantation and muscle regeneration.

39 oD expression during embryogenesis and adult muscle regeneration.

40 irects cell activities essential for cardiac muscle regeneration.

41 icantly reduced muscle fibrosis and improved muscle regeneration.

42 HIF-1alpha is required for adequate skeletal muscle regeneration.

43 siently during injury-induced adult skeletal muscle regeneration.

44 e, and that S1P biosynthesis is required for muscle regeneration.

45 such as obesity were linked with decline of muscle regeneration.

46 c deletion of MASTR in mice impairs skeletal muscle regeneration.

47 or muscle growth and maintenance and one for muscle regeneration.

48 pathway during myoblast differentiation and muscle regeneration.

49 This promotes efficient muscle regeneration.

50 other and with damaged myofibers to promote muscle regeneration.

51 , promote muscle degeneration and failure of muscle regeneration.

52 skeletal muscle, identifying a novel role in muscle regeneration.

53 the noncanonical Wnt pathway during skeletal muscle regeneration.

54 ned satellite cell proliferation and impeded muscle regeneration.

55 suggesting a mechanism by which A20 promotes muscle regeneration.

56 t in integrin-beta3 function could stimulate muscle regeneration.

57 ignaling to induce SC differentiation during muscle regeneration.

58 of Trpc1 in myoblast differentiation and in muscle regeneration.

59 regulatory network underlying the process of muscle regeneration.

60 lations with transient and enduring roles in muscle regeneration.

61 critical for designing therapy for skeletal muscle regeneration.

62 complex, as a pivotal regulator of skeletal muscle regeneration.

63 b ischemia promoted significant vascular and muscle regeneration.

64 ed role of intramuscular adipose in skeletal muscle regeneration.

65 they are essential for acute injury-induced muscle regeneration.

66 n-like growth factor-1 (IGF-1), and impaired muscle regeneration.

67 g neural cell adhesion molecule, a marker of muscle regeneration.

68 for Abcg2 in positively regulating skeletal muscle regeneration.

69 ple novel approaches to the problem of heart muscle regeneration.

70 mbryonic development, postlarval growth, and muscle regeneration.

71 ular mechanisms of CAC, focusing on impaired muscle regeneration.

72 cept for their exploitable effector roles in muscle regeneration.

73 is critical for the progression of skeletal muscle regeneration.

74 renewal, and significantly impaired skeletal muscle regeneration.

75 ins myocytes with central nuclei, indicating muscle regeneration.

76 n and proliferation, Zfp423 is essential for muscle regeneration.

77 adult satellite cells during homeostasis and muscle regeneration.

78 mplex protein SUN1 is required for efficient muscle regeneration.

79 Zfp423 regulates myogenic progression during muscle regeneration.

80 ery of blood flow regulation during skeletal muscle regeneration.

81 r (ALK4) as a mediator of muscle atrophy and muscle regeneration.

82 s, and recruited macrophages during skeletal muscle regeneration.

83 orts have not observed ECM-mediated skeletal muscle regeneration.

84 m cell dynamics during homeostatic aging and muscle regeneration.

85 efficient activation of mTORC1 and promotes muscle regeneration.

86 ayed a high self-renewal rate, which impairs muscle regeneration.

87 tronic enhancer activity, leading to lowered muscle regeneration.

88 mobilizes stem cells and restores youth-like muscle regeneration.

89 r of SC and MP amplification during skeletal muscle regeneration.

90 fast oxidative type IIa fibers, and impaired muscle regeneration ability, which are the reverse of wh

91 1(hi) macrophage populations during skeletal muscle regeneration after a sterile damage.

92 t the REV-ERB antagonist, SR8278, stimulates muscle regeneration after acute injury.

93 gene also reduced muscle injury and improved muscle regeneration after cardiotoxin injury, as well as

94 essed whether adiponectin has some impact on muscle regeneration after cardiotoxin-induced muscle inj

95 f NKX2-5 over-expression, we find defects in muscle regeneration after induced damage, similar to tho

96 Insufficient skeletal muscle regeneration after injury often impedes the heali

97 Muscle regeneration after injury was also impaired in Ba

98 Using a mouse model of skeletal muscle regeneration after injury, we identified hexameth

99 H19-deficient mice display abnormal skeletal muscle regeneration after injury, which is rectified by

100 which the inflammatory response facilitates muscle regeneration after injury.

101 into myotubes during muscle development and muscle regeneration after injury.

102 addition, miR-26a is induced during skeletal muscle regeneration after injury.

103 uency hearing deficits and impaired skeletal muscle regeneration after injury.

104 eveal a role for soluble CD163 in regulating muscle regeneration after ischaemic injury.

105 inhibition of Bhlhe40 or p53 may facilitate muscle regeneration after ischemic injuries.

106 owever, HIF1alpha negatively regulates adult muscle regeneration after ischemic injury, implying that

107 However, muscle regeneration after late (day 4) ablation was simi

108 However, the lack of Anx A1 delayed muscle regeneration after notexin-induced injury.

109 Bach1 knockout mice displayed impaired muscle regeneration, altered dynamics of the macrophage

110 iven mechanical compressions led to enhanced muscle regeneration and a approximately threefold increa

111 ) and neonatal represents a useful marker of muscle regeneration and a meaningful indicator of muscle

112 are medically relevant targets for enhancing muscle regeneration and ameliorating muscle pathology.

113 ion, low resveratrol doses promoted in vitro muscle regeneration and attenuated the impact of ROS, wh

114 Our results implicate dysregulation of muscle regeneration and cerebrospinal fluid homeostasis

115 toration of glycosylation is associated with muscle regeneration and dependent on the expression of b

116 iomechanical changes that accompany skeletal muscle regeneration and determined the implications on S

117 reviously unknown role of lipin1 in skeletal muscle regeneration and expands our understanding of the

118 that allowed for improvements in dystrophic muscle regeneration and function.

119 In addition, muscle regeneration and growth were greatly slowed by lo

120 in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential t

121 e new insights into the genetic circuitry of muscle regeneration and identify MASTR as a central regu

122 show age-dependent delays in injury-induced muscle regeneration and impaired muscle function.

123 stabilization of the motor nerves results in muscle regeneration and in atrophy especially in the cas

124 tellite cell differentiation during skeletal muscle regeneration and indicate that miR-206 slows prog

125 ificantly from therapies that both stimulate muscle regeneration and inhibit fibrosis.

126 lite cell is the primary cellular source for muscle regeneration and is equipped with the potential t

127 e protein (RTL1), which is also required for muscle regeneration and is expressed in regenerating/dys

128 s recognized that epicardium is required for muscle regeneration and itself has high regenerative pot

129 Severe burn injury induces skeletal muscle regeneration and myonuclear apoptosis.

130 e weakness, demyelinating neuropathy, failed muscle regeneration and premature death.

131 ellular basis of Cripto activity in skeletal muscle regeneration and raise previously undescribed imp

132 , ectopic miR-431 injection greatly improved muscle regeneration and reduced SMAD4 levels.

133 naling in the dKO mice with Y-27632 improved muscle regeneration and reduced the expression of BMPs,

134 atory myopathic cytokine.IMPORTANCE Skeletal muscle regeneration and repair involve the recruitment a

135 the development of potential therapeutics in muscle regeneration and repair.

136 k but not at 6 mo, and it improved diaphragm muscle regeneration and respiratory function at 14 wk bu

137 early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression towar

138 elated with sustained inflammation, impaired muscle regeneration and the rapid depletion and senescen

139 main display reduced myofiber size, impaired muscle regeneration, and derepression of muscle developm

140 n CKD, including proteolysis, myogenesis and muscle regeneration, and expression of proinflammatory m

141 letal muscle and cardiac pathology, improves muscle regeneration, and extends the lifespan.

142 ity, body weight, skeletal muscle histology, muscle regeneration, and gene expression.

143 ficient mice resulted in robust engraftment, muscle regeneration, and proper homing of human PAX7+ sa

144 ling by MEF2A is a requisite step for proper muscle regeneration, and represents an attractive pathwa

145 ite cells and exhibit delayed and protracted muscle regeneration, and satellite cell-derived myogenic

146 important role of complement C3a in skeletal muscle regeneration, and suggest that manipulating compl

147 Skeletal muscle fibrosis and impaired muscle regeneration are major contributors to muscle was

148 of specific populations of myeloid cells on muscle regeneration are presented, with an emphasis on h

149 rodents, the potential effects of Ang II on muscle regeneration are unknown.

150 g mainly through the restoration of impaired muscle regeneration, as fibrosis or inflammation was not

151 We also analysed muscle regeneration at the protein level by immunolabell

152 increased the myopathic lesion size, reduced muscle regeneration, attenuated muscle function, and exa

153 nitors (FAPs) that play a supportive role in muscle regeneration but may also cause fibrosis when abe

154 Immune factors are required for muscle regeneration, but chronic inflammation creates a

155 population dedicated to efficacious skeletal muscle regeneration, but their therapeutic utility is cu

156 n the Bach1 knockout in macrophages, impairs muscle regeneration by changing the dynamics of the macr

157 ay therefore regulate gene expression during muscle regeneration by controlling miRNA processing.

158 tment with PGE2 suffices to robustly augment muscle regeneration by either endogenous or transplanted

159 administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell a

160 Slug overexpression ameliorates aged muscle regeneration by enhancing SC self-renewal through

161 ce, which limits satellite cell function and muscle regeneration by Hoxa9-dependent activation of dev

162 MPs orchestrate multiple aspects of skeletal muscle regeneration by providing stage-specific immunomo

163 The premise of heart muscle regeneration by the transdifferentiation of bone

164 s of DMD; however, mdx mice display a strong muscle regeneration capacity, while dKO mice exhibit a m

165 in vivo, as USP19(-/-) mice display improved muscle regeneration concomitant with enhanced expression

166 demonstrates SOD1 toxicity effects on human muscle regeneration, contractility and metabolic functio

167 chanism in satellite cell homeostasis during muscle regeneration could help inform research efforts t

168 atellite cells of adult mice led to profound muscle regeneration defects and dramatically reduced lev

169 x7-expressing satellite cells and a profound muscle regeneration deficit that resembles the phenotype

170 Muscle regeneration depends on a robust albeit transient

171 te that OVL is beneficial to mdx muscle, and muscle regeneration does not mask the potentially detrim

172 In the muscle biopsy we found evidence of muscle regeneration due to previous necrotic lesions lik

173 that Linc-RAM knockout mice display impaired muscle regeneration due to the differentiation defect of

174 as no overt effect on mice but impairs adult muscle regeneration following acute damage; it also exac

175 , miR-210 inhibition did not affect skeletal muscle regeneration following cardiotoxin damage.

176 Interestingly, in an in vivo model of muscle regeneration following cardiotoxin injury, ectopi

177 Cobra Venom Factor (CVF) result in impaired muscle regeneration following cardiotoxin-induced injury

178 teady state conditions as well as a delay of muscle regeneration following cardiotoxin-mediated injur

179 ic Zfp423 deletion exhibit severely impaired muscle regeneration following injury, with aberrant SC e

180 n, and mitochondrial biogenesis for skeletal muscle regeneration following ischemic injury.

181 strategy to accelerate and enhance skeletal muscle regeneration for the treatment of muscular atroph

182 Signs of muscle regeneration give rise that ischemic muscle damag

183 Much of the focus in muscle regeneration has been placed on the identificatio

184 lls following muscle injury, but its role in muscle regeneration has not been defined.

185 asts, but its potential involvement in adult muscle regeneration has not been explored.

186 , but their potential contributions to adult muscle regeneration have not been systematically explore

187 During muscle regeneration, Hic1(+) derivatives directly contri

188 ults suggest that ERRalpha deficiency during muscle regeneration impairs recovery of mitochondrial en

189 Knockdown of MUNC in vivo impaired murine muscle regeneration, implicating MUNC in primary satelli

190 precursor cell differentiation and improved muscle regeneration in a separate, toxin-induced model o

191 tivation of TAK1 in satellite cells inhibits muscle regeneration in adult mice.

192 n factor plays an essential role in skeletal muscle regeneration in adult mice.

193 f Hoxa9 improves satellite cell function and muscle regeneration in aged mice, whereas overexpression

194 ulates the actions of ARNT, rescued skeletal muscle regeneration in both old and ARNT-deleted mice.

195 ng AT2R expression and its potential role in muscle regeneration in chronic diseases, we used a mouse

196 molecular switch in the regulation of HO and muscle regeneration in dystrophic skeletal muscle of mic

197 Muscle regeneration in FSHD was correlated with the path

198 The role of PDGF-BB in muscle regeneration in humans has not been studied.

199 We characterized the time course of skeletal muscle regeneration in lipin1-deficient fld mice after i

200 o effect, however, on either bone density or muscle regeneration in mice in which signaling was targe

201 ay gene expression data derived from in-vivo muscle regeneration in mice, both producing biologically

202 We also found that attenuated muscle regeneration in obese mice is rescued by AICAR, a

203 AMPK, but AICAR treatment failed to improve muscle regeneration in obese mice with satellite cell-sp

204 iding a convenient drug target to facilitate muscle regeneration in obese populations.

205 AMPK activity is a major reason for hampered muscle regeneration in obese subjects.

206 on of individual Mef2 genes has no effect on muscle regeneration in response to cardiotoxin injury.

207 te Numb, we determined that, in its absence, muscle regeneration in response to injury was impaired.

208 play decreased IGF2 induction and diminished muscle regeneration in response to injury, indicating th

209 required in the muscle stem cell lineage for muscle regeneration in response to injury.

210 Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury.

211 nuclei observed in muscle fibers suggest for muscle regeneration in these samples.

212 ed apoptosis, we report evidence of striated muscle regeneration in vivo in mice by human MiPs.

213 ontrols metabolic remodeling during skeletal muscle regeneration in vivo is unknown.

214 al muscle construct to accelerate functional muscle regeneration in vivo.

215 miR-206 is required for skeletal muscle regeneration in vivo.

216 l myogenesis and on nascent myofibers during muscle regeneration in vivo.

217 cells, and these actions concertedly inhibit muscle regeneration in vivo.

218 rentiation of myoblasts in vitro, and blocks muscle regeneration in vivo.

219 We characterized the time course of skeletal muscle regeneration in wild-type (M-ERRalphaWT) and musc

220 imental model of focal asynchronous bouts of muscle regeneration in wild-type (WT) mice.

221 jury AMPK activation was sufficient to delay muscle regeneration in WT mice.

222 crease satellite cell activation and improve muscle regeneration in young mice.

223 lso upregulated in cardiotoxin-induced mouse muscle regeneration, in human myositis and DMD biopsies,

224 s do not play a crucial role during skeletal muscle regeneration induced by sterile tissue damage.

225 ABSTRACT: Skeletal muscle regeneration is a complex interplay between vario

226 tanding the molecular mechanisms of skeletal muscle regeneration is crucial to exploiting this pathwa

227 Muscle regeneration is highly dependent on the ability o

228 Monocyte/macrophage polarization in skeletal muscle regeneration is ill defined.

229 We demonstrate that muscle regeneration is impaired with aging owing in part

230 Skeletal muscle regeneration is mediated by satellite cells (SCs)

231 The effect of complement in muscle regeneration is mediated by the alternative pathw

232 or development and that contrary to mammals, muscle regeneration is normal without functional Pax7 ge

233 lite cells are reduced after injury and that muscle regeneration is severely impeded, reminiscent of

234 To define their roles in muscle regeneration, L6E9 cells were used to perform in

235 al of laminin-111 protein therapy to improve muscle regeneration, laminin-111 or phosphate-buffered s

236 hibits satellite cell (SC) proliferation and muscle regeneration, likely contributing to cachexia in

237 Skeletal muscle regeneration mainly depends on satellite cells, a

238 icient satellite cells expanded and improved muscle regeneration more effectively than WT satellite c

239 During skeletal muscle regeneration, muscle stem cells (MuSCs) respond t

240 hey can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and

241 Although the molecular mechanism of muscle regeneration process after an injury has been ext

242 ital imaging for direct visualization of the muscle regeneration process in live mice, we report that

243 a key mediator linking obesity and impaired muscle regeneration, providing a convenient drug target

244 ient muscle was damaged with cardiotoxin and muscle regeneration quantified.

245 ignaling mechanisms governing adult skeletal muscle regeneration remain less understood.

246 alterations that may have a major impact on muscle regeneration remain poorly understood.

247 ish facilitated dynamic live cell imaging of muscle regeneration, repopulation of muscle stem cells w

248 levels, SPL also controls SC recruitment and muscle regeneration, representing a potential therapeuti

249 n adult satellite cells completely abolishes muscle regeneration, resulting in severe muscle destruct

250 Adult skeletal muscle regeneration results from activation, proliferati

251 Blocking Large upregulation during muscle regeneration results in the synthesis of dystrogl

252 n by infiltrating macrophages contributes to muscle regeneration, revealing a novel mechanism of infl

253 Muscle regeneration, sarcolemma integrity and fibrosis w

254 Additionally, burn injury induced skeletal muscle regeneration, satellite cell proliferation and fu

255 is severely impeded, reminiscent of hampered muscle regeneration seen in obese subjects.

256 Analysis of muscle regeneration showed a delay in recovery, probably

257 lexity and can determine the extent to which muscle regeneration succeeds.

258 to the inflammatory response during skeletal muscle regeneration, suppressed Fbxl2 mRNA expression in

259 termine the mechanisms underlying failure of muscle regeneration that is observed in dystrophic muscl

260 We found that AICAR increased skeletal muscle regeneration thereby decreasing the levels of del

261 t integrin-beta3 plays a fundamental role in muscle regeneration through a regulation of macrophage i

262 ve role in muscular dystrophies by enhancing muscle regeneration through activation of satellite cell

263 rthermore, we demonstrated that UTX mediates muscle regeneration through its H3K27 demethylase activi

264 ng the heart is activated by injury and aids muscle regeneration through paracrine effects and as a m

265 tly demonstrated that adiponectin stimulates muscle regeneration through T-cadherin, where intracellu

266 contribute to the understanding of skeletal muscle regeneration through the identification of Fbxl2

267 roves satellite cell activation and skeletal muscle regeneration through upregulation of Notch signal

268 ether, our results show laminin-111 restores muscle regeneration to laminin-alpha2-deficient muscle a

269 uent myotube formation, inefficient skeletal muscle regeneration upon injury, and aggravated pathogen

270 rentiating into myocytes and contributing to muscle regeneration upon injury.

271 cells that can participate in myogenesis and muscle regeneration upon transplantation.

272 Ang II inhibition of skeletal muscle regeneration via AT1 receptor-dependent suppressi

273 Here we show that Ang II reduced skeletal muscle regeneration via inhibition of satellite cell (SC

274 aling molecule that regulates myogenesis and muscle regeneration via MLX/IGF2/Akt signaling.

275 Muscle regeneration was delayed by angiotensin II infusi

276 In vivo, acute cardiotoxin-induced muscle regeneration was enhanced in S1PR3-null mice, wit

277 pression of myogenic genes was decreased and muscle regeneration was impaired, whereas fibrosis was e

278 Muscle regeneration was induced by injuring mouse muscle

279 we used a mouse model of CHF and found that muscle regeneration was markedly reduced and that this w

280 This delay in muscle regeneration was not caused by a slowdown in prol

281 nsistent with this finding, the capacity for muscle regeneration was severely impaired in mice defici

282 In line with in vitro results, muscle regeneration was stimulated, and muscle fiber siz

283 short-term OVL, which is believed to inhibit muscle regeneration, was not more detrimental to mdx tha

284 the potential involvement of MEF2 factors in muscle regeneration, we conditionally deleted the Mef2a,

285 to develop new strategies that could enhance muscle regeneration, we have developed and performed a h

286 To determine the potential role of AT2R in muscle regeneration, we infused C57BL/6 mice with the AT

287 gnaling in ischemia-induced inflammation and muscle regeneration, we subjected wild-type (WT) and TNF

288 To identify genes involved in muscle regeneration, we used a microarray analysis; ther

289 RP or anti-HMGCR Abs, mechanisms involved in muscle regeneration were also impaired due to a defect o

290 In summary, impairments in muscle regeneration were associated with exaggerated mon

291 early ablation and associated with impaired muscle regeneration were determined by flow cytometry.

292 and central nucleation, indices of skeletal muscle regeneration, were elevated in burn patients (P <

293 hMdm2 construct were unable to contribute to muscle regeneration when grafted into cardiotoxin-injure

294 n adult satellite cells compromises skeletal muscle regeneration, whereas gain of function of Cripto

295 lation of MyD88 reduces myofiber size during muscle regeneration, whereas its overexpression promotes

296 oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of

297 proliferation while simultaneously enhancing muscle regeneration, which is abrogated by adaptive tran

298 to M2 sequence is observed during postinjury muscle regeneration, which provides an excellent paradig

299 y leads to a profound disruption in skeletal muscle regeneration with an accumulation of SCs within t

300 There was also impaired muscle regeneration with an increase in muscle fibrosis.