ライフサイエンスコーパス: muscle spindle

1 otube strain sensor (acting as an artificial muscle spindle).

2 dentified intrafusal fibres in the dissected muscle spindles.

3 ed in intramuscular nerve branches to single muscle spindles.

4 sive intrafusal bag fibers within individual muscle spindles.

5 to the formation of morphologically abnormal muscle spindles.

6 pathway of differentiation that is unique to muscle spindles.

7 bout the same amount of phase advance as the muscle spindles.

8 ia correlated with postnatal degeneration of muscle spindles.

9 placement specialists and their provision of muscle spindles.

10 ion of the skin, mechanoreceptors, NMJs, and muscle spindles.

11 , is significantly reduced in mice that lack muscle spindles.

12 nymous and heteronymous feedback mediated by muscle spindles.

13 lbumin (Pv+) proprioceptor axons innervating muscle spindles.

14 MNs (gamma-MNs), which selectively innervate muscle spindles.

15 roprioceptive properties similar to those of muscle spindles.

16 to be regulated by factors originating from muscle spindles.

17 nals from periodontal ligaments and masseter muscle spindles.

18 sition can affect signalling from paraspinal muscle spindles.

19 ded, with 20% of units identified as primary muscle spindles, 37% as secondary muscle spindles, and 2

20 peared normal, Egr3-deficient animals lacked muscle spindles, a finding that is consistent with their

21 a provide no support for the hypothesis that muscle spindle abundance is related to anatomical specia

22 there appears to be regional differences in muscle spindle abundance, independent of muscle mass and

23 To investigate whether muscle spindle activation might be responsible for the r

24 from a musculoskeletal model and model-based muscle spindle activity.

25 Muscle spindle afferent (MSA) neurons can show rapid and

26 Stained mesencephalic trigeminal jaw-muscle spindle afferent axon collaterals and boutons wer

27 lyze the synaptic interactions of identified muscle spindle afferent axon terminals in the spinal cor

28 Two days later, 1-5 jaw-muscle spindle afferent axons located in the mesencephal

29 Jaw-muscle spindle afferent axons were then intracellularly

30 lularly stained mesencephalic trigeminal jaw-muscle spindle afferent boutons and trigeminal premotor

31 structure of 243 intracellularly stained jaw-muscle spindle afferent boutons located within the trige

32 ty of boutons were S type, a few labeled jaw-muscle spindle afferent boutons possessed a long, narrow

33 te is an important contributor to maintained muscle spindle afferent excitability and may suggest a t

34 eased glutamate is necessary for maintaining muscle spindle afferent excitability during static but n

35 of the VGLUT1 gene (VGLUT1(+/-) ), decreased muscle spindle afferent firing during sustained stretch

36 tagonist hemicholinium-3 similarly increased muscle spindle afferent firing frequencies during stretc

37 ignals are transformed into the diversity of muscle spindle afferent firing patterns observed experim

38 suggest a therapeutic target for normalizing muscle spindle afferent function.

39 voked excitation onto recipient muscles with muscle spindle afferent inputs only.

40 The alpha3 isoform was also observed within muscle spindle afferent neurons in dorsal root ganglia w

41 The intracellular response of jaw-muscle spindle afferent neurons was then characterized d

42 ormalities in the electrical excitability of muscle spindle afferent proprioceptive neurons in the we

43 ively these data suggest a modulation of the muscle spindle afferent response to stretch by AChRs in

44 Single unit muscle spindle afferent responses from isolated mouse ex

45 during midbrain stimulation with changes in muscle spindle afferent responses to muscle stretch.

46 uring locomotion we recorded Ia and group II muscle spindle afferent responses to sinusoidal stretch

47 ve ex vivo preparation to measure identified muscle spindle afferent responses to stretch and vibrati

48 c knockout of one allele of VGLUT1 decreases muscle spindle afferent static but not dynamic sensitivi

49 We report that glutamate increases muscle spindle afferent static sensitivity in an ex vivo

50 PIEZO2 has been identified as necessary for muscle spindle afferent stretch sensitivity, although th

51 xosomatic assemblage, implying that some jaw-muscle spindle afferent synapses with trigeminal motoneu

52 alpha/beta-LTM cutaneous and 0/9 Aalpha/beta-muscle spindle afferent units.

53 % of cutaneous LTM Aalpha/beta-units, but no muscle spindle afferent units.

54 Thus, multiple disynaptic jaw-muscle spindle afferent-motoneuron circuits exist.

55 to re-assess the coupling between secondary muscle spindle afferents (group II muscle afferents) and

56 Muscle spindle afferents (Ia fibers) grow ventrally thro

57 Jaw muscle spindle afferents (JMSA) in the mesencephalic tri

58 Proprioceptive feedback from Group Ia/II muscle spindle afferents and Group Ib Golgi tendon affer

59 Neuronal microcircuits involving jaw-muscle spindle afferents and jaw-elevator motoneurons we

60 ron synapses between peripherally damaged Ia muscle spindle afferents and motoneurons.

61 he formation of synaptic connections between muscle spindle afferents and spinal motor neurons are be

62 We have shown that functional muscle spindle afferents are absent in the upper and low

63 Given that functional muscle spindle afferents are also absent in the upper li

64 l horn interneurons with input from group II muscle spindle afferents are components of networks invo

65 Muscle spindle afferents are slowly adapting low thresho

66 Muscle spindle afferents are slowly adapting low thresho

67 amilial dysautonomia, do not have functional muscle spindle afferents but do have essentially normal

68 Here we show that signals in human muscle spindle afferents during unconstrained wrist and

69 cordings have been made from multiple single muscle spindle afferents from medial gastrocnemius (MG)

70 Recordings have been made from 127 single muscle spindle afferents from the longissimus lumborum m

71 Of the Aalpha/beta-LTM units, muscle spindle afferents had the fastest CV and AP kinet

72 The activity patterns of muscle spindle afferents in jaw-closer muscles were stud

73 Single unit recordings were obtained from muscle spindle afferents in the L6 dorsal roots of 30 Ne

74 connections and monosynaptic projections of muscle spindle afferents of individual heads of the long

75 made from gamma (gamma) motor axons and from muscle spindle afferents of the medial gastrocnemius (MG

76 The amplitude sensitivity of all jaw muscle spindle afferents was assessed by calculating the

77 Treatment of muscle spindle afferents with the high-affinity choline

78 te exists for recurrent feedback between jaw-muscle spindle afferents within Vme.

79 nsity in neuronal subgroupswere respectively:muscle spindle afferents(MSAs):-4.6 nA,-33 pA pF(-1); cu

80 the synergy between the mechanoreceptors and muscle spindle afferents, ten naturalistic textures were

81 stimulation or muscle stretch) also activate muscle spindle afferents, the selective role of GTOs rem

82 ession of NKAalpha3 in gamma-motoneurons and muscle spindle afferents, which may affect excitability

83 a profound effect on the firing patterns of muscle spindle afferents.

84 us had central projections characteristic of muscle spindle afferents.

85 ting the complex slowly adapting response of muscle spindle afferents.

86 Heg1 as a putative marker for proprioceptive muscle spindle afferents.

87 silateral ventrolateral funiculus (VLF)] and muscle spindle afferents.

88 iated by interneurons that share inputs from muscle spindles, among others.

89 ic stretch reflex, elicited by bypassing the muscle spindle and directly stimulating the afferent ner

90 peripherally located sensory apparatus, the muscle spindle and Golgi tendon organs.

91 In a recipient muscle that receives both muscle spindle and GTO projections, donor muscle stretch

92 This synergy between muscle spindle and mechanoreceptors in the proposed neur

93 tivity using a phenomenological model of the muscle spindle and muscle lengths derived from a musculo

94 se mice demonstrated that sensory endings of muscle spindles and Golgi tendon organs as well as the c

95 ensory endings of proprioceptors innervating muscle spindles and Golgi tendon organs in mice.

96 elimination of proprioceptive feedback from muscle spindles and Golgi tendon organs.

97 rn ErbB2 conditional knockout mice that lack muscle spindles and grow up to exhibit dysfunctional pro

98 n in satellite cells, although expression in muscle spindles and reactivation of the locus in myonucl

99 eptive sensory neurons that mainly innervate muscle spindles and tendons is sufficient to induce DA5-

100 gamma-MNs innervate intrafusal fibers of the muscle spindle, and regulate sensitivity of the muscle s

101 as primary muscle spindles, 37% as secondary muscle spindles, and 24% as cutaneous afferents.

102 olely to the phase advance introduced by the muscle spindles, and show that a major additional contri

103 to assess its similarity to that of the rat muscle spindle annulospiral ending we have described pre

104 es, the instantaneous firing rates (IFRs) of muscle spindles are associated with characteristics of s

105 Muscle spindles are commonly considered as stretch recep

106 Muscle spindles are complex stretch-sensitive mechanorec

107 Muscle spindles are encapsulated sensory organs found in

108 As muscle spindles are involved in the sensation of positio

109 Muscle spindles are skeletal muscle sensory organs that

110 Muscle stretch proprioceptors (muscle spindles) are required for stretch reflexes and l

111 ry mechanosensory afferents, using adult rat muscle spindles as a model system.

112 might be adaptive for precise calibration of muscle spindles as sense organs.

113 ons at Ia/II proprioceptive nerve endings in muscle spindles before the symptomatic phase of the dise

114 Egr3 was highly expressed in developing muscle spindles, but not in Ia afferent neurons or their

115 We therefore conclude that muscle spindles can act as "forward sensory models": the

116 fy how much the primary afferent activity of muscle spindles can contribute to shaping muscle coactiv

117 Clearly, the lack of muscle spindles compromised proprioception at the knee b

118 In some cases the ensemble muscle spindle data encoded the instantaneous trajectory

119 was remarkably well encoded in the ensemble muscle spindle data.

120 splay an early-onset sensory neuropathy with muscle spindle deficiency.

121 ed Egr3-null mutant mice (Egr3-/-), in which muscle spindles degenerate progressively after birth.

122 rat somatic neurons is determined by target-muscle spindle-derived factors.

123 viously unknown dependence of gamma-MNs on a muscle spindle-derived, GDNF-independent signal during t

124 and uncovered an essential role for EGR3 in muscle-spindle development.

125 The initiation of muscle spindle differentiation requires neuregulin 1, de

126 he vertebra was repositioned identically and muscle spindle discharge at rest and to movement was com

127 Lack of muscle spindle feedback from the legs may account for th

128 known in the cat to receive donor excitatory muscle spindle feedback only, inhibitory GTO feedback on

129 As a partial validation of muscle-spindle feedback gains, we compared the sign of t

130 At the molecular level, muscle spindle fibers express a unique subset of myosin

131 expression is required for the formation of muscle spindle fibers, sensory organs that are distinct

132 e, there are history-dependent transients of muscle spindle firing that are not uniquely related to m

133 Proprioception is sensed by muscle spindles for precise locomotion and body posture.

134 uncovered LRP4 as an unexpected regulator of muscle spindle formation and maintenance in adult and ag

135 By isolating muscle spindles from ssTnT-KO and control mice aiming to

136 commands to the muscle (alpha drive) versus muscle spindle (gamma drive) can cause highly variable a

137 ive elimination of neurotrophin 3 (NT3) from muscle spindles had no effect on the amplitude of affere

138 Group Ia/II sensory feedback from muscle spindles has a predominant influence in patternin

139 n particular, we demonstrate that, as in the muscle spindle: (i) FM1-43 labels the sensory terminals

140 The muscle spindle Ia afferent system, however, is sharply f

141 ll-known firing characteristics of mammalian muscle spindle Ia afferents - including movement history

142 ocal inhibition mediated by length sensitive muscle spindle Ia afferents and Ia interneurones.

143 the entire time course of transient IFRs in muscle spindle Ia afferents during stretch (i.e., length

144 are discussed in relationship to the role of muscle spindle Ia afferents in focal dystonia.

145 vibratory stimulus (a selective stimulus for muscle spindle Ia afferents).

146 of a steady monosynaptic input generated by muscle spindle Ia afferents.

147 Monosynaptic connections between muscle spindle (Ia) afferents and motoneurons (MNs), the

148 e cross-bridge dynamics in history-dependent muscle spindle IFRs in passive muscle lengthening condit

149 cle spindle, and regulate sensitivity of the muscle spindle in response to stretch.

150 Muscle spindles in Egr3-/- mice do not express NT3.

151 The lack of conventional muscle spindles in face muscles raises the question of h

152 erents was correlated with a degeneration of muscle spindles in skeletal muscle.

153 in afferent and efferent neurons innervating muscle spindles in the peripheral nervous system (PNS) o

154 sms involved in establishing and maintaining muscle spindle innervation and function are still poorly

155 c mouse models are related to alterations in muscle spindle innervation.

156 ted with the equatorial and polar regions of muscle spindle intrafusal fibers.

157 importance, the molecular composition of the muscle spindle is largely unknown.

158 ndance of these sensory organs, particularly muscle spindles, is known to differ considerably across

159 iptomic and proteomic datasets of the entire muscle spindle isolated from the murine deep masseter mu

160 Surprisingly muscle spindle macrophages express neuron-like gene expr

161 Here, the potential additional roles for muscle spindle macrophages in muscle contraction and loc

162 ensory neurons innervating stretch-sensitive muscle spindles make monosynaptic excitatory connections

163 nding on the neuromechanical conditions, the muscle spindle model output appears to 'encode' aspects

164 ngth and velocity, nor reproduced by current muscle spindle models.

165 elongation, can modulate the efficacy of the muscle spindle-motoneurone connection both after periphe

166 eedback mainly derives from groups Ia and II muscle spindle (MS) afferents and group Ib Golgi tendon

167 SIGNIFICANCE STATEMENT Sensory feedback from muscle spindle (MS) and Golgi tendon organ (GTO) sensory

168 ng (SA) hairy and glabrous units, n = 2; and muscle spindle (MS) units n = 17).

169 rioceptors, the Golgi-tendon organ (GTO) and muscle spindle (MS), to detect elbow torques, since touc

170 At the heart of this process lie the muscle spindles (MS), specialized receptors finely attun

171 hanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs).

172 a significant positive relationship between muscle spindle number and fibre length, emphasising the

173 et the specification of MNs and induction of muscle spindles occurs normally.

174 computer modelling study was carried out on muscle spindles of the cat tenuissimus muscle to examine

175 Ia afferents induce the formation of muscle spindles prenatally and maintain them postnatally

176 on the amplitude and velocity sensitivity of muscle spindle primary afferent neurons in the trigemina

177 Recordings were made from muscle spindle primary afferents from medial gastrocnemi

178 We demonstrate that muscle spindle primary afferents in passive muscle fire

179 ir role in mechanosensory function using the muscle spindle primary endings of rat Ia afferents as a

180 Muscle spindle proprioceptive receptors play a primary r

181 heir peripheral targets and reconstitute the muscle spindle proprioceptive receptors.

182 dult Egr3-deficient mice are ataxic and lack muscle spindle proprioceptors that normally develop at t

183 Large sensory axons innervating muscle spindles provide feedback for balance and gait an

184 Finally, neurotrophin 3 released from muscle spindles regulates the strength of sensory-motor

185 Thus, NT3 derived from muscle spindles regulates the synaptic connectivity betw

186 of the dorsal root ganglia (DRG) that supply muscle spindles require target-derived factors for survi

187 acetylcholine receptors negatively modulate muscle spindle responses to stretch.

188 ompatible with monosynaptic coupling between muscle spindle secondaries and gamma-motoneurones.

189 on of intrafusal fibres possibly fine-tuning muscle spindle sensitivity.

190 We simulated muscle spindle signals through musculoskeletal modeling

191 We collected muscle spindle spike trains across a variety of muscle s

192 Vertebrate muscle spindle stretch receptors are important for limb

193 hat Myf5 is also constitutively expressed in muscle spindles-stretch-sensitive mechanoreceptors, whil

194 ce brightly labels hair cells, Merkel cells, muscle spindles, taste buds, enteric neurons, and primar

195 tional indexes and a significant increase in muscle spindles that remained associated with axons.

196 s of primary and secondary endings of single muscle spindles to activation of gamma-motoneurones by n

197 og kg(-1)) had no effect on the responses of muscle spindles to tendon stretch and to succinylcholine

198 ated as an artificial proprioception sensor (muscle spindles) to assess the instantaneous speed of th

199 All glabrous skin and muscle spindle units and in hairy skin slowly adapting a

200 ral sensory input from receptors such as the muscle spindle, which detects changes in the length of s

201 ed of proprioceptive sensory neurons and the muscle spindle, which is embedded in the muscle tissue a

202 that macrophages can reside in proximity to muscle spindles, which are sensory neurons sensing muscl

203 , including nerve fibers, nerve bundles, and muscle spindles, which are stretch-sensitive mechanorece

204 f information about hand postures stems from muscle spindles, whose responses can also signal isometr

205 Further, mechanical interactions of the muscle spindle with muscle-tendon dynamics reveal how mo

206 neuronal models and for the discharge of the muscle spindle, without their significance for the moton