ライフサイエンスコーパス: muscularis

1 ation compared with the naive LPS-stimulated muscularis.

2 erminal centers, but prominent in the tunica muscularis.

3 hagocytes was observed within the intestinal muscularis.

4 morphology and ultrastructure of the tunica muscularis.

5 ould still be observed within the intestinal muscularis.

6 stry localized iNOS in phagocytes within the muscularis.

7 t iNOS messenger RNA induction in mucosa and muscularis.

8 BMP4 in the gizzard caused a thinning of the muscularis.

9 itial cells of Cajal (ICC) within the tunica muscularis.

10 al redistribution of flow between mucosa and muscularis.

11 hase) within the reperfused intestinal graft muscularis.

12 ution in ICC we mapped throughout the tunica muscularis.

13 ript for GPBAR1 were detected in gallbladder muscularis.

14 r mRNA induction within the small intestinal muscularis.

15 nic LPS and microspheres into the intestinal muscularis.

16 decrease in neutrophil infiltration into the muscularis after intestinal manipulation compared with w

17 massive extravasation of leukocytes into the muscularis after surgical manipulation of the small bowe

18 on of microsphere-laden monocytes within the muscularis, although a significant monocytic recruitment

19 eutrophils and monocytes into the intestinal muscularis and a functional suppression in jejunal circu

20 itment of monocytes and neutrophils into the muscularis and also averted jejunal circular muscle dysf

21 inflammatory response within the intestinal muscularis and causes intestinal muscle dysfunction.

22 1,N(6) -etheno-NAD (eNAD) in colonic tunica muscularis and in SMCs, ICC and PDGFRalpha(+) cells with

23 Muscularis and mucosa extracts were isolated from the in

24 erferon-gamma mRNA was localized to both the muscularis and mucosa.

25 nsic sympathetic neurons innervating the gut muscularis and norepinephrine signaling to beta2 adrener

26 e-positive immune cells that infiltrated the muscularis and prevented the surgically induced reductio

27 icant incorporation was also observed in the muscularis and vascular endothelium.

28 d with respect to its transmural (mucosa vs. muscularis) and geographical (proximal jejunum, mid-smal

29 sed neutrophil infiltration into the jejunal muscularis; and (3) prevented SITx-induced suppression o

30 Resident macrophages within the tunica muscularis are known to play a crucial role in initiatin

31 plification of IFNy signalling in the tunica muscularis are required for a measured inflammatory resp

32 ctivation of resident macrophages within the muscularis associated with dysmotility.

33 caused an increase in flow heterogeneity in muscularis at both high and low flow states, and in muco

34 ly upregulated in the hydrogen-treated graft muscularis but not mucosa before reperfusion.

35 r significantly less apoptosis in the tunica muscularis compared with tacrolimus monotherapy.

36 red from serum, peritoneal lavage fluid, and muscularis culture media.

37 Nitrite and NO production were measured in muscularis cultures.

38 rom all regions through the thickness of the muscularis demonstrated intrinsic pacemaker activity, an

39 gitudinally and circumferentially within the muscularis, differentiated into neurons and glia, and ex

40 oration in skeletal muscle of the dystrophia muscularis (dy/dy) mouse and its milder allelic variant,

41 ; p < 0.001), and positively correlated with muscularis elastin area fraction (p = - 0.78; p = 0.004)

42 demonstrate that resident macrophages of the muscularis externa (MM ) refine the ENS early in life by

43 The H2O2 increased in the muscularis externa 1-7 days after inflammation was induc

44 Igsf3 KO mice shows reduced thickness of the muscularis externa and diminished number of enteric neur

45 al manipulation leads to inflammation of the muscularis externa and disrupts motility.

46 rs of the myenteric and submucosal plexuses, muscularis externa and lamina propria of the gastrointes

47 sion; expression of NGF increased in colonic muscularis externa and mucosa/submucosa.

48 Normal human muscularis externa contained numerous macrophages that e

49 We localized PAR-2 to the muscularis externa of the rat colon by immunofluorescenc

50 The muscularis externa recovered and developed tolerance to

51 h but not Gli1 at E10.5; the 2 layers of the muscularis externa respond differently to Hedgehog signa

52 Histochemistry of the graft's muscularis externa showed a significant thickening due t

53 gainst esophageal circumference enlargement, muscularis externa thickening, and collagen deposition.

54 duction of POI activated the inflammasome in muscularis externa tissues of C57BL6 mice, and IL-1alpha

55 mechanisms to a subsequent insult within the muscularis externa.

56 ttributed to their release from the inflamed muscularis externa.

57 inflammatory response within the intestinal muscularis externa.

58 cular region, forming a structure called the muscularis externa.

59 macrophages is distributed in the intestinal muscularis externa.

60 ned to enteric neurons and fibers within the muscularis externa.

61 e, nerve growth factor in the gastric fundus muscularis externae, brain-derived neurotrophic factor i

62 eta, TNF-alpha, iNOS, and COX-2 mRNAs within muscularis extracts after incision.

63 Antioxidant capacity and muscularis heme oxygenase-1 upregulation are possible pr

64 ry and electron microscopy of the intestinal muscularis identified the phagocytes as extravasating ED

65 Here, we mapped the muscularis immune cell landscape, revealing that diverse

66 lminth Heligmosomoides polygyrus and blunted muscularis immune responses.

67 nd beta2-adrenergic receptors in the oviduct muscularis implies that a basal endocannabinoid tone in

68 inflammatory responses within the intestinal muscularis in mouse and rat models of POI.

69 se in MMP-9 expression within the intestinal muscularis; increases in MMP-9 messenger RNA were induci

70 On postsurgical days 1 and 7, muscularis infiltrates were characterized immunohistoche

71 Muscularis infiltration of neutrophils and monocytes wer

72 ignificantly alleviated the small intestinal muscularis inflammation and prevented intestinal muscle

73 Surgically induced intestinal muscularis inflammation has been hypothesized as a mecha

74 gically altered colon or by small intestinal muscularis inflammation itself.

75 handling initiates a molecular and cellular muscularis inflammation that has been associated with iN

76 s and monocytes were counted, and intestinal muscularis inflammatory mediators were quantified by qua

77 mopoietic cells contribute to TLR4-sensitive muscularis inflammatory signaling, but nonhemopoietic TL

78 The serosal/muscularis layer remained relatively unaffected.

79 a was more densely populated than the serosa/muscularis layer, indicating preferential temporal and s

80 were injected into the duodenal and pyloric muscularis layer.

81 iNOS mRNA was detected in the mucosal and muscularis layers after the initiation of colitis.

82 tramural distribution to mucosal and serosal/muscularis layers were determined using the radioactive

83 response within the postsurgical intestinal muscularis, leading to an exacerbation of postoperative

84 Muscularis leukocytic infiltrates were characterized.

85 that surgical trauma is followed by resident muscularis macrophage activation and the upregulation, r

86 We found that following enteric infections, muscularis macrophages (MMs) acquire a tissue-protective

87 olonic lamina propria macrophages (LpMs) and muscularis macrophages (MMs) consist of monocyte-like ce

88 nsic EANs (iEANs) and the role of intestinal muscularis macrophages (MMs) in this context.

89 pro-inflammatory phenotype when compared to muscularis macrophages (MMs), which displayed a tissue-p

90 plastic, microbiota-driven crosstalk between muscularis macrophages and enteric neurons that controls

91 Despite established interactions between muscularis macrophages and neurons, the presence and fun

92 We demonstrate that, in the steady state, muscularis macrophages regulate peristaltic activity of

93 -2 messenger RNA and protein within resident muscularis macrophages, a discrete subpopulation of myen

94 rons, glia, interstitial cells of Cajal, and muscularis macrophages.

95 and damage may have been limited by resident muscularis macrophages.

96 The decrease in blood flow to the muscularis may contribute to loss of intestinal wall per

97 protein expression was increased within the muscularis microvasculature, and ICAM-1 and LFA-1 were e

98 the 'neuro-effector' junction in the tunica muscularis might consist of synaptic-like connectivity w

99 villous width, villous perimeter per 100 mum muscularis mucosa (a measure of epithelial surface area)

100 and villous cross sectional area per 100 mum muscularis mucosa (a measure of villous compartment volu

101 thelial basement membrane and the underlying muscularis mucosa (lamina propria lymphocytes), or in or

102 blood vessels, which are located between the muscularis mucosa and circular muscular layer of the hum

103 h and intestine at E16; and after birth, the muscularis mucosa and villus smooth muscle consist prima

104 s, loss of smooth muscle in villus cores and muscularis mucosa as well as crypt hyperplasia.

105 d be due to altered properties of ICs or the muscularis mucosa in the bladders of these animals.

106 Adenocarcinoma invasive deeper than the muscularis mucosa is associated with a significant incre

107 contains cell-populated mucosa and an intact muscularis mucosa layer.

108 d preservation of the muscularis propria and muscularis mucosa was determined histologically.

109 Smooth muscle cells of the muscularis mucosa, in close proximity to proliferative c

110 ithelium, inflamed lamina propria, congested muscularis mucosa, necrotized submucosa, and disorganize

111 ercent of the Delay group had atrophy of the muscularis mucosa, whereas 19% of Immediate animals had

112 to the loss of visceral SMCs disrupting the muscularis mucosa.

113 urothelium and bladder detrusor, termed the muscularis mucosa.

114 erosa (median, 245 vs 64 mum; P = .019), and muscularis mucosae (median, 451 vs 80 mum; P = .031) wer

115 , 5-HT(4) receptor agonism in the rat tunica muscularis mucosae (TMM) assay, and for 5-HT(3) receptor

116 6 weeks, alpha 8 expression localized to the muscularis mucosae and villus core.

117 In rabbit colonic muscularis mucosae cells, tyrosine-phosphorylated protei

118 vide a basis for analyses of the role of the muscularis mucosae in ISC regulation.

119 stologic grade, lymphocytic infiltration, or muscularis mucosae invasion, was associated with cancer

120 ononuclear leukocytes and hyperplasia of the muscularis mucosae smooth muscle cells (M-SMCs).

121 Muscularis mucosae, a specialized muscle layer, first ap

122 ved stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the ly

123 ts heavily to the circular muscle layer, the muscularis mucosae, and to other myenteric neurons.

124 ng tumor infiltration of the lamina propria, muscularis mucosae, and/or submucosa.

125 does not preclude cancer invasion beyond the muscularis mucosae, cautioning against the use of mucosa

126 al architecture, demonstrated by loss of the muscularis mucosae, deterioration of the extracellular m

127 smooth muscle layer of the colon, the tunica muscularis mucosae, were examined using the patch clamp

128 id lymphocytic infiltrate extending into the muscularis mucosae.

129 cle layer and, later, to the villus core and muscularis mucosae.

130 significant leukocyte extravasation into the muscularis of all groups.

131 ls of the islet and a subset of cells in the muscularis of arteries in a distribution identical to en

132 intestinal segments and within the isolated muscularis of chronically rejecting intestinal allograft

133 aused a significant up-regulation within the muscularis of ICAM-1 and P-selectin messenger RNA.

134 athways exist within the thick-walled tunica muscularis of large mammals.

135 cells of Cajal (ICC) exist within the tunica muscularis of the gastric antrum, and these cells serve

136 The muscularis of the gastrointestinal (GI) tract consists o

137 uted in specific locations within the tunica muscularis of the gastrointestinal (GI) tract.

138 We isolated ENS progenitors from tunica muscularis of the small intestine of newborn (postnatal

139 ocalized by immunofluorescence in the tunica muscularis of the vas deferens.

140 eNAD exposed to colonic muscularis of wild-type mice produced eADPR, eAMP and eA

141 1,N(6) -etheno-NAD (eNAD) in colonic tunica muscularis of wild-type, Cd38(-/-) , Nt5e(-/-) , Enpp1(-

142 ed four populations of ICC within the antral muscularis on the basis of anatomical location.

143 um of the heart, skeletal muscle, intestinal muscularis, or brain capillaries or the nondiaphragmed f

144 ee of trauma, the activation of resident gut muscularis phagocytes, and the extent of cellular infilt

145 xpressed in leukocytes within the intestinal muscularis plays a major role in mediating smooth muscle

146 ochondrial function affects the IJP, colonic muscularis preparations were treated with the mitochondr

147 ecruitment of immune cells to the intestinal muscularis, preventing loss of smooth muscle contractili

148 n of Ba2+ (1-100 microM) to strips of tunica muscularis produced depolarization of cells along the su

149 11) had a smaller area of tissue outside the muscularis propria (P = 0.04) compared with the CRM-nega

150 the submucosa low signal intensity, and the muscularis propria an intermediate signal intensity.

151 deep esophageal tissue injury involving the muscularis propria and adventitia layers.

152 -beta 1 was localized in muscle cells of the muscularis propria and in culture.

153 cm in diameter with infiltration through the muscularis propria and into the subserosal fat.

154 Width differences of internal muscularis propria and mucularis mucosae were associated

155 osis was quantified, and preservation of the muscularis propria and muscularis mucosa was determined

156 Chronic rejection caused thickening of muscularis propria by both hyperplasia (175.5%) and hype

157 arly in the definition of penetration of the muscularis propria by rectal cancer (74% vs 58%).

158 2 days old Wistar rats, or sections from the muscularis propria containing the myenteric plexus from

159 In the esophagus and rectum, the muscularis propria could be visualized as separate circu

160 dividual layers of circular and longitudinal muscularis propria developed tension in response to carb

161 and intramesorectal groups compared with the muscularis propria group were 0.32 (0.16-0.64) and 0.48

162 1%) for intramesorectal, and 13% (8-21%) for muscularis propria groups.

163 ble lesions that appear to be limited to the muscularis propria have a high chance of cure with sphin

164 ificant decrease in goblet cell hyperplasia, muscularis propria hypertrophy, villus blunting, and exp

165 in the proportion of each plane of surgery: muscularis propria in 95 of 399 (24%) specimens, intrame

166 the marked inflammatory infiltrate into the muscularis propria indicates that the graft muscle is in

167 -distal rectum with minimal extension beyond muscularis propria into the mesorectal fat, but without

168 llary transitional cell carcinoma (TCC) with muscularis propria invasion (Fig 1).

169 ic subepithelial tumors originating from the muscularis propria layer and larger than 2 cm, complete

170 re smaller than 5 cm and originated from the muscularis propria layer of the stomach, as shown by end

171 ic subepithelial tumors originating from the muscularis propria layer, and to evaluate its efficacy a

172 ion, particularly those originating from the muscularis propria layer.

173 Smooth muscle cells were isolated from muscularis propria of stricturing CD or normal margins.

174 rcinoma or urothelial carcinoma invading the muscularis propria of the bladder.

175 sa and submucosa on the one hand, and of the muscularis propria of the bowel wall on the other, it mi

176 heteroechoic solid mass originating from the muscularis propria of the distal esophagus.

177 The muscularis propria of the esophagus is organized into ci

178 infection in the smooth muscle cells of the muscularis propria of the intestine.

179 dvanced (T3 with >/=5 mm invasion beyond the muscularis propria or T4) tumours from 35 UK centres wer

180 c plane surgery compared with surgery in the muscularis propria plane (HR 0.57 [0.38-0.85], p=0.006)

181 intramesocolic (mean 2109 [1273] mm(2)) and muscularis propria plane (mean 1447 [913] mm(2)) surgery

182 ed with intramesocolic (mean 30 [16] mm) and muscularis propria plane (mean 21 [12] mm) surgery, whic

183 te (intramesorectal) in 398 (34%), and poor (muscularis propria plane) in 154 (13%).

184 TEC architecture is identical to native with muscularis propria staining for actin, acetylcholinester

185 ignificant increase in the distance from the muscularis propria to the mesocolic resection margin wit

186 an distance of full-thickness atrophy of the muscularis propria was 0.10 mm (IQR 0-0.60 mm) in the De

187 monstrated, and in four (57%), breach of the muscularis propria was correctly predicted.

188 Mean cross-sectional tissue area outside the muscularis propria was significantly higher with mesocol

189 rea of surgically removed tissue outside the muscularis propria was smaller in APR specimens (n = 27)

190 Intestinal smooth muscle (muscularis propria) from individuals with FVM had reduce

191 icted T2/T3a/T3b (less than 5 mm spread from muscularis propria), regardless of MRI N stage.

192 e mucosa, 16 to the submucosa, and 13 to the muscularis propria, and 55 were transmural.

193 ma, histologically normal mucosa, submucosal muscularis propria, and histologically normal mucosa dis

194 Studies localized TGF-beta within the muscularis propria, identified the cellular source, meas

195 gastric wall infiltration (submucosa, n = 4; muscularis propria, n = 3; serosa, n = 1).

196 al subepithelial tumors originating from the muscularis propria, respectively.

197 external (median, 929 vs 632 mum; P = .013) muscularis propria, serosa (median, 245 vs 64 mum; P = .

198 influx of neutrophils into the submucosa and muscularis propria.

199 with both hyperplasia and hypertrophy of the muscularis propria.

200 cosa, necrotized submucosa, and disorganized muscularis propria.

201 y interface and travel along EGCs within the muscularis propria.

202 MRI in the assessment of the invasion of the muscularis propria.

203 gastrointestinal tumors originating from the muscularis propria.

204 gastrointestinal tumors originating from the muscularis propria.

205 ntermediate urothelial cells, as well as the muscularis propria.

206 teric neurons and smooth muscle cells in the muscularis propria.

207 The developing muscularis (propria and mucosae) showed accentuated alph

208 These data suggest that the tunica muscularis provides a suitable microenvironment for the

209 inflammatory response within the intestinal muscularis, resulting in paralytic ileus.

210 Preconditioning of the muscularis showed significant cross-tolerance to the fun

211 -cell transcriptomics analysis of the tunica muscularis showed that glia-specific abrogation of IFNy

212 ngly, positively hybridized cells within the muscularis tended to preferentially localize to the myen

213 nflammatory response in the small intestinal muscularis that contributes to postoperative ileus.

214 n about the specific cells within the tunica muscularis that express PARs and the mechanisms leading

215 inflammatory response within the intestinal muscularis that is associated with a subsequent decrease

216 ocal inflammatory cascade within the colonic muscularis that mediates smooth muscle dysfunction, whic

217 AOS in both esophageal mucosa and esophageal muscularis tissue.

218 ory and granulomatous response of the tunica muscularis to helminths.

219 termediate on T2-weighted images and that of muscularis was low.

220 ed in diameter and hypertrophy of the tunica muscularis was observed oral to the obstruction site.

221 lease and apoptosis of uterine epithelia and muscularis were hallmarks of the LPS model.

222 Zymography analysis, performed in muscularis whole mounts in situ, indicated that MMP-9 an

223 Leukocyte extravasation was investigated in muscularis whole mounts.

224 try for neutrophils was performed in jejunal muscularis whole mounts.

225 emical techniques were applied to intestinal muscularis whole-mounts.

226 d capillary transit times in both mucosa and muscularis, with relative dispersions (SD/Mean) ranging

227 balanced by a decrease in blood flow to the muscularis, with total mesenteric flow remaining unchang