ライフサイエンスコーパス: mutability

1 tructure on their genomic representation and mutability.

2 m appears to favor a certain innate level of mutability.

3 suggested that growth limitation stimulates mutability.

4 lls evade therapeutic pressures by enhancing mutability.

5 e mutability without requiring any change in mutability.

6 ously found to have elevated post-UV plasmid mutability.

7 sequences and elevated levels of spontaneous mutability.

8 of the PKD1 gene may be responsible for its mutability.

9 disease mutants, emphasizing ubiquitin code mutability.

10 erse optimality that is inversely related to mutability.

11 acquisition of drug resistance by increasing mutability.

12 the variable region significantly alters its mutability.

13 ble for both their striking polymorphism and mutability.

14 s other than the one that led to its initial mutability.

15 of slippage, are the strongest predictors of mutability.

16 lar isochore do not influence microsatellite mutability.

17 he tumors exhibit the phenotype of increased mutability.

18 murine germline V genes to predict regional mutabilities.

19 of the cj1139 tract from G8 to G11 increased mutability 10-fold and changed the mutational pattern fr

20 l and regional differences in 8-oxoG-induced mutability across genomes are currently unknown.

21 a strong, positive relationship between the mutability-adjusted proportion of singletons (MAPS) metr

22 We develop intergenic mutability-adjusted proportion singleton (iMAPS), a gene

23 t bias is revealed by a defined hierarchy of mutability among di- and trinucleotide sequences located

24 also incorporated variation in the degree of mutability among genes, using either gamma-distributed m

25 regional genomic factors to the variation in mutability among orthologous human-chimpanzee microsatel

26 ally crucial DNA sequences due to their high mutability and abundance in the human genome.

27 ltogether, our analyses suggest that epitope mutability and accessibility to immune complex assembly

28 oximately 90% of variation in microsatellite mutability and can generate useful predictions for the s

29 riggers spontaneous DNA breakage, leading to mutability and cancer predisposition.

30 ctivities, suggesting an influence on genome mutability and functional variation.

31 f phase variation demonstrated links between mutability and genetic diversity but could not replicate

32 he hallmarks of cancer is the extremely high mutability and genetic instability of tumor cells.

33 (1) promoting antigenicity through increased mutability and genomic instability, (2) enhancing adjuva

34 fluenza A viruses (IAV) exhibit vast genetic mutability and have great zoonotic potential to infect a

35 oscale sequence alterations tune the in vivo mutability and promote mutations in an otherwise cold re

36 tudy was to estimate the relative effects of mutability and selection on SNP density in transcribed r

37 chimpanzee, aiming to dissect the impact of mutability and selection on their evolution.

38 gated, but the reason for the high degree of mutability and specificity at these sites is uncertain.

39 High mutability and the likelihood of cancer can be caused by

40 a moderate correlation between the relative mutability and thermodynamic stability of DNA triplets e

41 Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo.

42 , to enable a high-level of controllability, mutability and versatility for reconfigurable multifunct

43 that manifests itself via different modes of mutability and/or repair at mononucleotide loci.

44 aracterized by chromosome fragility, altered mutability, and abnormal regulation of the nonhomologous

45 s results in a large increase in spontaneous mutability, and in the case of mice and men, predisposit

46 s of lowering fidelity on virus replication, mutability, and in vivo fitness.

47 RAF inhibition induced DNA damage, increased mutability, and triggered microsatellite instability.

48 Interestingly, much of this mutability appears to be focused on the third codon posi

49 The primary cause of mutability appears to be hydrolytic deamination.

50 npaired during transcription, their relative mutabilities are calculated using a new computer algorit

51 Reduced mutability around methylated CpGs is also observed in ca

52 This study has explored intrinsic mutability as a consequence of sequence-specific repair

53 phase variation without increases in overall mutability, as they possessed low rates of spontaneous m

54 nd nonredundant roles in suppressing C --> T mutability at non-CpG sites.

55 pair-defective strains also showed increased mutability at the hotspot, consistent with the notion th

56 rfibrillar stiffness (EIF), the mechanism of mutability at the nanoscale can be demonstrated directly

57 ts a systematic variation of mutation rates (mutability) at exon flanks, depending on the local CpG c

58 om these mutants arise from general adaptive mutability available to any chromosomal gene.

59 that captures the structural constraints on mutability based on the extent of its inter-residue inte

60 Nevertheless, the relative mutabilities both within this set and within the SAN (S

61 nfirm earlier observations regarding residue mutabilities but also suggest that in addition to the es

62 the contrary, stress has no direct effect on mutability but favors only growth of cells that amplify

63 on increased both cellular resistance to and mutability by nitrous acid.

64 ither intragenic recombination nor increased mutability can explain the observed patterns.

65 Localized hyper-mutability caused by accumulation of lesions in persiste

66 mutations reveal rather similar patterns of mutability compared with point mutations, being rare at

67 This finding is consistent with the modest mutability conferred by inactivation of the MutSalpha PC

68 22, Asn-226, and Asn-229 exhibited the least mutability, consistent with x-ray data showing that each

69 combined effects of Darwinian selection and mutability contribute substantially to, but do not fully

70 spike protein, we observe that the predicted mutability correlates well with experimental measures of

71 itivity to UV-B irradiation increased and UV mutability decreased by 12- to 14-fold.

72 prominent systems for the study of adaptive mutability depend on the specialized activities of genet

73 Enhancer mutability depends on DNA replication direction and is c

74 Mutability depends on hotspots, not secondary structure.

75 We determine what factors contribute to this mutability difference and characterize the strength of s

76 n preferences in VH genes, observed relative mutability differences between regions are more extreme

77 ingly, sheep sequences show extremely strong mutability differences, consistent with the role of soma

78 ing enrichment from 1.8- to 90-fold of local mutability distributed across 283 sites in the genome th

79 rains, which arises from the vastly enhanced mutability due to defects in the proofreading functions

80 independent of the site-by-site variation in mutability due to different CpG contexts.

81 positive selection for cells with increasing mutability during cancer dissemination.

82 , we discuss a number of issues (e.g., locus mutability, failure to saturate, number of gametes to sc

83 rease in survival and a 200-fold increase in mutability following a UV-B dose of 1,900 J m(-2).

84 We also observed a trend for high predicted mutability for codon positions 1 and 2 in complementarit

85 or the 2009 H1N1 and SARS-CoV-2 pandemics, a mutability gradient along the main axis of the spike was

86 antibody-targeting gradient, which matches a mutability gradient along the main axis of the spike.

87 Historically, DNA sequence mutability has been considered relatively uniform and lo

88 rom 123,415 sequences, we found that the SHM mutability hierarchies on microsequence motifs (i.e., SH

89 y, gonadal dysgenesis and P-element-mediated mutability; however, individual lines carrying these con

90 lular phenotype, we examined post-UV plasmid mutability in 31 lymphoblastoid cell lines from 6 famili

91 pothesis whereby adaptive mutation is normal mutability in amplified DNA.

92 ow that SIRs confer an increase in localized mutability in breast cancer, which is domain-dependent w

93 Thus, alt-NHEJ, which contributes to genetic mutability in cancer cells, also plays a novel role in e

94 found an abnormally elevated post-UV plasmid mutability in cell lines from 13 of 13 patients with CM

95 of somatic hypermutation results in greater mutability in complementarity-determining regions of the

96 We confirm that STR mutability in CRC highly depends on the MSI status, repe

97 st three decades has described an impressive mutability in dendritic-spine number and morphology unde

98 A genome-wide view of sequence mutability in mice is still limited, although biologists

99 Overall mutability in Neisseriae can be described by measuring b

100 tation recurrences in patients by background mutability in order to find mutations which may be under

101 iation were accompanied by increased overall mutability in some N. meningitidis isolates including st

102 dative stress as a potential source of hyper-mutability in ssDNA by modulation of the endogenous ROS

103 thers have speculated that an enhancement of mutability in the complementarity-determining regions (C

104 roblem, including the necessity to introduce mutability in the data structure to comply with the "rig

105 e of being advantageous) and/or decrement of mutability in the framework regions (FR; where mutations

106 r, none had any effect on P-element-mediated mutability in the male germ line.

107 and structural SD diversity, which increases mutability in the population and predisposes specific ha

108 ted the influence of nucleosome stability on mutability in vivo.

109 iously observed enhanced radioresistance and mutability in WTK1 cells must be attributed to a more co

110 Second, mutability increases nonuniformly with length, suggestin

111 unpaired during transcription; and (ii) the mutability index (MI) for each base, expressed as an abs

112 Increased mutability is an intrinsic property of SIRs as evidenced

113 e provide evidence indicating that this high mutability is due to a saturation of the DNA mismatch re

114 the intermediate range (34-37 repeats), the mutability is increased, frequently leading to alleles o

115 Mutability is influenced by factors that increase the li

116 ence; and a state of elevated microsatellite mutability is interspersed across the genome.

117 fall into three distinct categories: 1) The mutability is sharply higher at CG dinucleotides under m

118 show that a feature of the Lac(+) and Trp(+) mutability is the accumulation of Trp(+) and Lac(+) reve

119 Adaptive mutability is the apparent alteration in specificity or

120 t its major advantage, its messages' dynamic mutability, is still unexplored.

121 Apparent directed mutability, its recombination requirement, and its appar

122 Here, we present MULAN (MUtability LANdscape inference), a maximum-likelihood co

123 t by inferring full evolutionary history and mutability landscape of a tumor.

124 ility rates of clonal populations form their mutability landscapes.

125 th extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to

126 These results suggest that inducible mutability may present a reasonable strategy for adaptiv

127 utability values, indicating that background mutability might limit mutation occurrence.

128 or-free DNA repair in a DR region of minimal mutability (MMDR region).

129 The mutability modulated by AID hotspots and coldspots chang

130 ination is not the cause, the high degree of mutability must presumably reflect the inherent properti

131 e microsatellite instability and spontaneous mutability observed in the msh2 mutant, yeast cells harb

132 which is domain-dependent with the greatest mutability observed within spacer sequences ( approximat

133 e two sets of patterns are very similar: the mutabilities of nucleotide triplets are positively corre

134 ed nucleotide variants is asymmetric and the mutabilities of the different amino acids are very diffe

135 We examined the mutability of 328 amino acids in the mature PorB protein

136 MBD4 might function in vivo to minimize the mutability of 5-methylcytosine by removing its deaminati

137 We explored this issue by testing the mutability of a non-Ig transcription cassette in Ig and

138 t the identity of the 3' base can affect the mutability of a purine by oxidative damage by as much as

139 Therefore, the mutability of AID target cytosines is determined by a mo

140 e odds from the perspective of the intrinsic mutability of AIV rather than the ecological constraints

141 Here, we predict the mutability of all positions in SARS-CoV-2 protein domain

142 The mutability of bacteriophages offers a particular advanta

143 nfluences not only the survival but also the mutability of cells in response to IR.

144 two knock-in models to directly compare the mutability of core Smu and VDJ exon sequences and their

145 The mutability of cortical function implies a continual proc

146 cting protein domains, but suggests that the mutability of different regions of a protein in such a t

147 ng flanking sequences modifying the relative mutability of dispersed expanded human triplet repeats.

148 We found that mutability of driver mutations was lower than that of pa

149 In this study, we analyzed the mutability of each residue using an approach that captur

150 Moreover, we found an increased mutability of eSTRs in MSI tumours.

151 atch repair in vivo and suggest that the low mutability of exonuclease-deficient strains is a consequ

152 reated an experimental system to analyze the mutability of Friedreich's ataxia (GAA)(n) repeats durin

153 bust to different models of variation in the mutability of genes.

154 The enormous genetic diversity and mutability of HIV has prevented effective control of thi

155 elopment and observed an average decrease in mutability of less than 10 percent over time.

156 In vivo, MBD4 functions to reduce the mutability of methyl-CpG sites in the genome and mice de

157 The dynamic mutability of microsatellite repeats is implicated in th

158 ystallinity, permanent porosity and chemical mutability of MOFs to achieve deep structural insights t

159 Fourth, mutability of mononucleotide microsatellites is impacted

160 We present evidence that mutability of motif A has been conserved during evolutio

161 The mutability of motif II in 210 active mutants has paralle

162 y which inherited polymorphism regulates the mutability of nearby sequences.

163 ion frequency of Hb receptors or the general mutability of Neisserial strains.

164 ebellum, and pons + medulla) demonstrate the mutability of network architecture in response to the ad

165 d in nontumorous human lung and to study the mutability of p53 codons 157, 248, 249, and 250 to benzo

166 delta pip mutations eliminate almost all the mutability of pol2-4 msh2Delta or pol3-01 pol2-4 adds st

167 g the metabolism of palindromic repeats, the mutability of quasipalindromic triplet repeats, and the

168 Because of the high mutability of retroviruses, it is not the generation of

169 However, a molecular basis for the high mutability of RGYW was not known until recently.

170 Our work forges ground in showing that the mutability of RNA viruses does have an upper limit, wher

171 ost species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of eme

172 It is also apparent that changes in the mutability of specific loci can be influenced by alterat

173 randomized controlled trials to explore the mutability of such beliefs and their link to parental in

174 The peculiar site-specific mutability of such repeats can provide populations with

175 amino acid substitutions, we determined the mutability of the 13 constituent amino acids Val(700)-Ar

176 nvestigated whether natural selection and/or mutability of the antibody variable region contributed s

177 etermined experimentally correlated with the mutability of the bases as predicted by mfg.

178 ount the protein dynamics, accessibility and mutability of the binding site and the putative mechanis

179 an important role in determining the overall mutability of the clinical isolates.

180 Furthermore, the mutability of the CpG dinucleotide has led to the deplet

181 addition there were striking differences in mutability of the different nucleotides within the restr

182 chance (p = 1.2 x 10(-8)) given the size and mutability of the gene.

183 Since the relative mutability of the GNN-encoded amino acids does not expla

184 However, the high mutability of the influenza virus represents a design ch

185 ironmental factors can modify the number and mutability of the MMR-deficient stem cells.

186 The high mutability of the polymerase active site in vivo and the

187 a gene is polymorphic mostly depends on the mutability of the site.

188 We describe the mutability of the Trp(-) chromosomal +1 frameshift mutat

189 peared substantially guided by the intrinsic mutability of the VH1-46 gene, which closely resembled V

190 n why a vaccine is not available is the high mutability of the virus, which enables it to evolve muta

191 no success, due, in large part, to the high mutability of the virus.

192 targeting did correlate positively with the mutability of the wider sequence neighborhood surroundin

193 ile the rarity of CG is ascribed to the high mutability of this dinucleotide, the rarity of TA in cod

194 Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are im

195 The complexity and rapid mutability of tumors, however, enable them to develop re

196 he phenomenon can be explained by the higher mutability of unprotected cytosines.

197 ensive analysis of ClinVar to understand the mutability of variant evaluation in channelopathy-associ

198 w that Hot can also cause an increase in the mutability of various E. coli strains (mutator effect).

199 V(beta) sequences resemble immunoglobulin in mutability pattern, suggesting one of several alternativ

200 We find that the mutability patterns in a number of species are similar t

201 These variations in mutability phenotypes are predictive of progression outc

202 s suggests that some sequences have inherent mutability, possibly due to sequence-related differences

203 protein stability and that both are reliable mutability predictors (receiver operating characteristic

204 ere we report that the di- and trinucleotide mutability preference pattern is shared by mouse introni

205 A transfer may be a prominent feature in the mutability process that occurs during nonlethal selectio

206 des evidence that, during transcription, the mutability (propensity to mutate) of a base in a DNA sec

207 fects of selection (functional category) and mutability (relative mutation rate) on the PSSs and foun

208 herichia coli, in which the stationary-phase mutability requires homologous recombination functions.

209 tations were characterized by relatively low mutability, resulting in an inversed U-shaped trend.

210 We compiled a mutability score that reflects the degree to which a par

211 pparent alteration in specificity or rate of mutability seen in bacteria during stress.

212 y adjusting mutation recurrence frequency by mutability significantly improved ranking of mutations a

213 mononucleotide tracts seemed to affect their mutability significantly.

214 genes exhibit microsatellite instability and mutability similar to that in the msh2 mutant.

215 Despite their high mutability, stable allele frequency distributions are ty

216 -avoidance systems results in extremely high mutability that can lead to error catastrophe.

217 ulting in a subset of bacteria with elevated mutability that often remain hypermutable for the durati

218 perly account for variation in site-specific mutability, thereby yielding many false-positives.

219 ntly increase their mutation rates (adaptive mutability), thus improving the likelihood of survival.

220 ardless of its original phenotype, increased mutability to a level seen in the fast strain.

221 d to calculate expected DNA and protein site mutability to decouple relative contributions of mutagen

222 silience to overcome replication stress, and mutability to escape the immune system and chemotherapeu

223 cancer (CRC) cells likewise exploit adaptive mutability to evade therapeutic pressure.

224 UV mutability to rifampin resistance (Rif(r)) was detected

225 opposed to its proposed role as a source of mutability to select specific tumor-prone aneuploid cell

226 We calculated nucleotide and codon mutability to study the contribution of background proce

227 Changing CAGGTG to AAGGTG reduces the mutability to that of the non-RS transgenes without alte

228 onstructs, we determined that rulAB restored mutability to the Escherichia coli umuDC deletion mutant

229 We showed that mutations with higher mutability values had higher observed recurrence frequen

230 yet observed in any tumor had relatively low mutability values, indicating that background mutability

231 Third, mutability varies among microsatellites with different m

232 f the CpG dinucleotide, which makes arginine mutability very much higher than other amino acids) rath

233 rulAB-induced UV mutability was also tracked in phyllosphere populations

234 No effect on apoptosis, radiosensitivity or mutability was observed when the HPV16 E6 gene was intro

235 Searching for general adaptive mutability, we have investigated the behavior of Salmone

236 t of serogroup A isolates possessed elevated mutability, which could be divided into two classes: int

237 enetics, forensics, etc.), due to their high mutability within and between species.

238 e growth can give the appearance of adaptive mutability without requiring any change in mutability.

239 ity (CIN), based on the assumption that high mutability would be detrimental in karyotypically aberra