ライフサイエンスコーパス: mutant

1 of EBV gH/gL and the EBV gH/gL-N(69)L/S(71)V mutant.

2 We further generated a lon-2 deletion mutant.

3 y, and in vitro evaluation against the C165S mutant.

4 of for in pr1 cells phenocopies the for null mutant.

5 reas spores were nearly absent in the double mutant.

6 cted with a lytically replicating KSHV BAC16 mutant.

7 into wild-type oocytes phenocopied the MIHR mutants.

8 is upregulated in imbibed seeds of drt111-2 mutants.

9 ke protrusions, which are absent in beta-Pix mutants.

10 ic subunits were affected in the phosphatase mutants.

11 ns in wild type Arabidopsis, but not in msh2 mutants.

12 tenuated colonization caused by the virulent mutants.

13 of apoptosis found in the beta-catenin S45F mutants.

14 morphogenic phenotypes of both cop1 and pifQ mutants.

15 f a library of 484 transcription factor null mutants.

16 lopment but not germ cell induction in Tfap2 mutants.

17 meristems observed in fbl17 loss-of-function mutants.

18 type (Col-0) or rescue of GA-deficient dwarf mutants.

19 more defective than those from larp6a single mutants.

20 formation than seen in either of the single mutants.

21 type, 21 IDH mutant/1p19q intact, and 19 IDH mutant/1p19q codeleted), the classification accuracy was

22 le of 49 gliomas (nine IDH wild type, 21 IDH mutant/1p19q intact, and 19 IDH mutant/1p19q codeleted),

23 responses to both wild-type (D614) and D614G mutant(2) SARS-CoV-2 as well as CD8(+) T cell responses,

24 for an insertional Chlamydomonas reinhardtii mutant affected in theVTC2 gene encoding GDP-l-Gal phosp

25 The exo70A1 mutant affected SNARE distribution and suppressed vesicl

26 ein in Arabidopsis and that the fertile ask1 mutant allowed us to uncover a comprehensive set of SCF

27 ble mutants displayed more release than Syt1 mutants alone, indicating SYT7 does not mediate the resi

28 Serratia plymuthica Serratiochelin-producing mutants also displayed a decreased growth rate under iro

29 Biological profiling and mutant analysis revealed that this compound is a prodrug

30 Double- and triple-mutant analysis shows that DRT111 controls splicing of A

31 grative strategy including enzymatic assays, mutant analysis, metabolic engineering, isotope labeling

32 p1 were performed by constructing a knockout mutant and analyzing the resulting heterokaryon.

33 ad compound 48c, induced necrosis in several mutant and FLT3-resistant AML cell lines and primary bla

34 contrast, assembly of equimolar mixtures of mutant and wild-type desmin generated chimeric filaments

35 he proteomic landscape of ALS-related Ubqln2 mutants and identifies candidate client proteins that ar

36 ity-stability tradeoffs for the advantageous mutants and provide a mechanistic explanation for Lon's

37 Here we use Arabidopsis thaliana ecotypes, mutants and transgenic lines to determine how control of

38 in extra surviving cells in a weak ced-3(-) mutant, and suppresses the embryonic lethality of a muta

39 Specifically, mac1Delta/Delta mutants are profoundly deficient in mitochondrial respir

40 While mutant ATXN1 is expressed throughout the brain, patholog

41 tho, we used the BK/BK mouse (homozygous for mutant Becn1(F121A) ) with increased autophagic flux, an

42 rminus of Brd4, but in all other aspects the mutant behaves differently between the two families of p

43 uired for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 increases survi

44 mutated MPNs, defective interactions between mutant calreticulin, ERp57, and STIM1 activated SOCE and

45 Nevertheless, this mutant can induce early gene expression, suggesting a po

46 It has been shown that the M125Q CaM mutant can mimic the functional effects of methionine ox

47 reshold proliferative advantage, below which mutants cannot persist.

48 Fur protein is ~31% in the E. coli iscA/sufA mutant cells and is decreased to ~4% in WT E. coli cells

49 wn tooth development genes) was perturbed in mutant cells and quite significantly for PAX9 and RUNX2.

50 In vitro, VE-cadDEE mutant cells displayed defects in polarization and cell

51 t, thus prompting the question of how single mutant cells give rise to neoplasia.

52 rift and can also cause downward invasion of mutant cells in the crypt.

53 ed in both bleached mutants, indicating that mutant cells retain some plastid remnants.

54 t to enable survival and proliferation of CI mutant cells under nutrient stress conditions.

55 stabilization, in Arabidopsis lnp1-1 lnp2-1 mutant cells, the ER becomes a dense tubular network.

56 This mutant chimera enabled us to determine the cryoelectron

57 llular context using the thermosensitive CCT-mutant CHO-MT58 cell line.

58 els was weaker for the JNCL-related missense mutant CLN3(R334C) and for a JNCL-related C-terminal del

59 ) and for a JNCL-related C-terminal deletion mutant (CLN3DeltaC).

60 broad loss of neural APA in elav/fne double mutant CNS, the first genetic background to largely abro

61 tivating gene (Rag) failed to show rescue of mutant colonization.

62 h prevented IFN-gamma production and rescued mutant colonization.

63 e approach for treating patients with PIK3CA-mutant colorectal cancers and warrants further clinical

64 of wild-type E-cadherin and cis-interaction mutants combined with simulations demonstrate that both

65 Transcriptomic analysis of multiple myc mutants confirmed that MYCs are required for full expres

66 compared with wild-type, but not in the tt4 mutant, consistent with opposite effects of these mutant

67 Immunoprecipitation of wild-type and mutant constructs showed that IQGAP1 associated with cdc

68 ur menthol binding models with thermodynamic mutant cycle analysis.

69 and suppresses the embryonic lethality of a mutant defective for the apoptotic suppressor ced-9/Bcl-

70 f the model plant Arabidopsis thaliana and a mutant defective in mRNA methylation (m(6)A).

71 -type B anthracis strain or with an isogenic mutant deficient for the protective antigen.

72 omyelitis, we examined survival of S. aureus mutants deficient in central metabolic pathways, includi

73 antly improve the physiology of NPC assembly mutants, despite having only negligible effects when NPC

74 nd rule pathway ubiquitin E3 ligases in NatB mutants did not restore NAD(+) levels.

75 In order to overcome the limitations of the mutant DISC1 model and understand the putative regional

76 g is suppressed in constant light, and PRL-1 mutants display a delayed phase under short, but not lon

77 Maize rtn2 mutants display increased autophagy and up-regulation of

78 to the late-onset defects, given that hira-1 mutants display mitochondrial stress, and the induction

79 The osvoz1 and osvoz2 single mutants display modest but opposite M. oryzae resistance

80 M120A and background mutants display significantly reduced substrate binding,

81 lutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts reg

82 Syt1/Syt7 double mutants displayed more release than Syt1 mutants alone,

83 The two frameshift mutants displayed reduced photosynthesis efficiency and

84 bhlh121 loss-of-function mutants displayed severe defects in Fe homeostasis that

85 DeGeRing might facilitate the generation of mutant DNA sequences for protein engineering and the fun

86 pts of scyl-1 are greatly decreased in adr-1 mutants due to deficient RNA editing at a single adenosi

87 cture and functional properties of the SERCA mutant E340A.

88 ingly we found that the mitochondrial fusion mutants eat-3 and fzo-1 are more resistant to both heat

89 Mutant embryos display epidermal hyperplasia, but also a

90 catenin is enhanced in Med23(fx/fx);Wnt1-Cre mutant embryos, which, together with downregulation of C

91 group received adenovirus type 5 host range mutant empty vector and alum.

92 deficits in gene regulatory activity of the mutant ERalpha proteins.

93 The pfl2 mutant exhibited reduced capsule production only in gala

94 Consistent with this, phyB mutants exhibited a freezing-sensitive phenotype, wherea

95 skin) and distant organs (intestine) in tert mutants exhibited higher levels of senescence and inflam

96 elevated iron levels in the hemolymph, Tsf1 mutants exhibited increased susceptibility to Pseudomona

97 Surprisingly, the gpa-3;nlp-24 double mutants exhibited much higher dauer formation than seen

98 r results with a new Lpar1 conditional mouse mutant expand an understanding of LPA(1) signaling in th

99 Similarly, DAAM mutants express invariably high levels of Ena in vitro.

100 Patients were categorised by EZH2 status: mutant (EZH2(mut)) or wild-type (EZH2(WT)).

101 Eggs from larp6b single mutant females showed minor chorion defects, but chorion

102 rions from eggs laid by larp6a;larp6b double mutant females were more defective than those from larp6

103 structure ceases to amplify selection if the mutant fitness advantage r is larger than r .

104 Finally, knockout mutants for 41 genes belonging to the different function

105 In this study, we engineered and selected mutant forms of uPlm that are both catalytically active

106 th and seed development because of nonviable mutant gametes.

107 Following maxillary tooth injury, Smoc2(-/-) mutants had increased osteoclast activity and bone resor

108 ng can also be observed in single and double mutants harboring vps35Delta.

109 This mutant has an unusual mechanism as it depletes normal-fu

110 he salicylic acid-deficient Arabidopsis eds5 mutants have an unnoticed fah1-2 background mutation, wh

111 d-type (WT) background, suggesting that such mutants have the potential to promote tumor karyotype ev

112 s supports the notion that patients with IDH-mutant high-risk LGG regardless of codeletion status rec

113 +) mice, expressing the pathogenic human Tau mutant (hTau-P301L), the hTau S199 phosphorylation was a

114 Here, we show that mutant huntingtin (mHtt) aggregates associated with Hunt

115 The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in

116 aggregation of the intrinsically disordered mutant Huntingtin (mHtt) vis-a-vis the pathogenicity of

117 ed and can induce responses in patients with mutant IDH2 myelodysplastic syndromes, including in thos

118 e inhibitor BAY11-7085 and dominant-negative mutant IkappaBalphaM inhibited NF-kappaB activity and in

119 lial cells by expressing a hyperactive STAT5 mutant in the mammary gland during postlactational remod

120 frequently used as a catalytically inactive mutant in vivo (based on in vitro peptide studies) actua

121 ing wild-type SERCA2b or a redox-insensitive mutant in which C674 is replaced by serine (C674S) were

122 showcases the utility of yeast phospholipid mutants in dissecting the phospholipid requirements of i

123 The fitness of mutants in each gene under each condition was then asses

124 scores the importance of employing true null mutants in genetic complementation studies.

125 We found that the defects of the bon mutants in osmotic stress responses were suppressed by m

126 Mutants in other proline-glutamate (PE)/PPE clusters, re

127 e generated high depth RNA-sequencing on FUS mutants in parallel to FUS knockout, allowing us to comp

128 Here, we show that Drosophila mutants in the homolog of the human CYFIP1, a gene linke

129 , NT5C2 mutations in six patients, and PRPS1 mutants in two patients.

130 ies were reduced in cpk3/5/6/11/23 quintuple mutants, in correlation with the stomatal opening phenot

131 Experimental analysis of the DLC1 mutants indicated 7 of 9 mutants whose lesions were loca

132 acylglycerols were detected in both bleached mutants, indicating that mutant cells retain some plasti

133 Conversely, the phosphomimetic IFITM3(Y20E) mutant induced oncogenic PI3K signalling and initiated t

134 This mutant interacted with zDHHC17 more strongly but was S-a

135 rrelates with reduced AKT signaling in Pcdhg mutant interneurons, and is rescued by genetic blockade

136 The fixation probability of a single mutant invading a population of residents is among the m

137 ons in the ADAR- and ERI-6/7/MOV10-defective mutant is associated with the induction of the unfolded

138 Retention of phosphomimetic dCENP-A mutants is reduced relative to wildtype, while non-phosp

139 We demonstrate that the scoliosis in dstyk mutants is related to the wavy and malformed notochord s

140 Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approve

141 ite 2-hydroxyglutarate via inhibition of the mutant isocitrate dehydrogenase 1 (IDH1; mIDH1) enzyme.

142 In human cancer cells that harbor mutant KRAS and WT p53 (p53), KRAS contributes to the ma

143 that ATP7A, a copper-exporter upregulated by mutant KRAS, is essential for neoplastic growth.

144 ficantly inhibited the cell proliferation of mutant KRAS-expressing cells.

145 le analyses of surrounding groups for WT and mutant KSIs provided insights into the forces and intera

146 Adenovirus mutants lacking E1B55K or E4orf6 display defects in vira

147 Arabidopsis (Arabidopsis thaliana) knock-out mutants lacking either phot2 or chup1 and analyzed the k

148 the best characterized function of mtFAS, as mutants lacking lipoylation have an intact ETC.

149 plete loss of hair-cell function, tmc triple-mutant larvae retain normal gross morphology of hair bun

150 dorferi proteins, lipid immunogens, and live mutants lead the design of canonical vaccines aimed at d

151 In a screen of an insertional mutant library of all 14 annotated PTS permease (EIIC) g

152 ease in membrane saturation in the fat1Delta mutant, likely accounting for UPR induction.

153 Similar to the rgi1/2/3/4/5 quintuple mutant, loss-of-function mutants of MPK3 and MPK6, MKK4

154 erials and Methods Data in patients with IDH-mutant lower-grade gliomas (World Health Organization gr

155 derived from idiopathic patients (AHNPs) and mutant LRRK2 patients showed differences between both ph

156 Supplementing gut-sterilized p53-mutant mice and p53-mutant organoids with gallic acid re

157 Homozygous mutant mice develop lethal postnatal inflammation of the

158 Lobular appendages are present in mutant mice lacking BCs, implying that although synchron

159 We also find that the Ttbk2 conditional mutant mice quickly lose cilia throughout the brain.

160 the conduction velocity of sciatic nerves of mutant mice showed an 80% decrease, the mice displayed o

161 Partial loss-of-function Fech(m1Pas) mutant mice showed reduced retinal neovascularization an

162 We crossed diabetic leptin receptor-mutant mice to mice lacking CaMKIIdelta globally.

163 ce and were significantly upregulated in the mutant mice, indicating that pre-translational splicing

164 ed striatal phenotypes in heterozygous Disc1 mutant mice, which could be a promising model of DISC1 h

165 min-positive GABAergic interneurons in Grin1 mutant mice.

166 ble behaviors, respectively, in male PC-Tsc1 mutant mice.

167 , learning, and memory are impaired in these mutant mice.

168 IDH1) enzyme, approved for treatment of IDH1-mutant (mIDH1) acute myeloid leukemia (AML).

169 nse beyond those of the synthetic lethal p53 mutant/MK2 combination alone.

170 In a genetic mutant model of retinitis pigmentosa, a lead compound, Q

171 l of the left ventricle of RyR2 wild type or mutant mouse hearts.

172 at this process requires factors involved in mutant mRNA decay, as in zebrafish and mouse.

173 known as "tassel blasting." We identified a mutant, necrotic upper tips1 (nut1), that mimics tassel

174 four major subtypes (i.e., BRAF-mutant, NRAS-mutant, NF1-deficient, and triple wild-type).

175 elanoma into four major subtypes (i.e., BRAF-mutant, NRAS-mutant, NF1-deficient, and triple wild-type

176 pping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for

177 the expression of the DNA-binding-deficient mutant of NuMA affects chromatin decondensation at the m

178 roach to score the distribution of the tsO45 mutant of VSVG protein in Rab6 depleted cells, we found

179 mycorrhizal colonization was reduced in mlo mutants of barley, wheat, and M. truncatula, and this wa

180 Enzymatically-compromised mutants of CypD show reduced abilities to dissociate alp

181 n of TRIF and generated STING-noninteracting mutants of human and mouse TRIFs.

182 1/2/3/4/5 quintuple mutant, loss-of-function mutants of MPK3 and MPK6, MKK4 and MKK5, or YDA show a s

183 upted by the expression of dominant-negative mutants of Rab5 and Rab11.

184 of T3D/T1L L3S2, we screened for hyperstable mutants of T3D/T1L L3S2 and identified three point mutat

185 tants share light-associated phenotypes with mutants of the phytochrome B photoreceptor, such as dela

186 compromised such as in temperature-sensitive mutants of Tim17.

187 t, consistent with opposite effects of these mutants on lateral root emergence.

188 the functional effect of the four stillbirth mutants on TRPM7 ion channel function in heterologous ce

189 nting gut-sterilized p53-mutant mice and p53-mutant organoids with gallic acid reinstated the TCF4-ch

190 (2+) elevation, and Ca(2+) influx in octuple mutant ovules rescues LURE1.2 secretion.

191 istically, the tumour-suppressive effects of mutant p53 were driven by disruption of the WNT pathway,

192 ity was independent of its canonical target, mutant p53, and was better associated with glutathione m

193 KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is charac

194 d that Parkinson's disease-associated Parkin mutants, ParkinR42P and ParkinG430D, are selectively exc

195 Consistent with this, the hec mutants partially suppress photomorphogenic phenotypes o

196 ine learning model was able to identify EGFR-mutant patients in multiple validation sets with globall

197 Interestingly, the PRL-1 mutant period lengthening is suppressed in constant ligh

198 Mutant peripheral-blood cells showed decreased ubiquityl

199 We report that mutant pfk13 has emerged independently in Guyana, with g

200 Rescue of unc-13/Munc13 mutant phenotypes by overexpressed open UNC-64/syntaxin

201 ssion of KCS1 in akr2a mutants rescued akr2a mutant phenotypes, including chilling sensitivity and a

202 d cause salicylic acid- and EDS5-independent mutant phenotypes.

203 anscriptome analysis of Arabidopsis thaliana mutant plants in PAP-SAL1 pathway revealed that the ferr

204 While mutant plants lacking xanthophylls are capable of photoa

205 In the zmnlp5 mutant plants, loss of the ZmNLP5 function led to change

206 ere further studied by phenotyping knock-out mutant plants.

207 on atlases, variation datasets and sequenced mutant populations, provides a foundation to identify ge

208 Structures of mutant pre-ribosomes lacking the tunnel domain of uL4 re

209 f Src or overexpression of a kinase-dead Src mutant prevented the effect of leptin, whereas a Src kin

210 The Fgpal1 mutant produced conidia with fewer septa and more nuclei

211 f-function JAK1 genetic variant results in a mutant protein with mosaic expression that drives multi-

212 and of trigenic interactions for the double mutant, provides insight into their roles and a quantita

213 The mutant quenches light-induced rhodopsin signaling like w

214 Using cells expressing a WT or S838A/T841A mutant RB fragment, we present evidence that deficiency

215 (W571) from its typical pocket in these Env mutants renders the Env insensitive to CD4 binding.

216 Overexpression of KCS1 in akr2a mutants rescued akr2a mutant phenotypes, including chill

217 2 system makes it possible to create a large mutant resource for S. viridis in a rapid and high throu

218 ventral striatum of D2R knockout mice, this mutant restored basal locomotor activity and cocaine-ind

219 In particular, vps13A mutants result in the neurodegenerative disorder Chorea-

220 Infection of HPCs with an HCMVDeltamiR-US5-2 mutant resulted in decreased TGF-beta expression and res

221 nfection with the recombinant A4G (rA4G) RSV mutant resulted in transcriptional readthrough and lower

222 entally generated C-terminal truncated KCNQ3 mutants retain the ability to assemble with KCNQ2.

223 is shows that rcy1Delta and snx4Delta single mutants retain the ability to recycle Snc1, but a snx4De

224 Crystal structures of arsenic-bound p53 mutants reveal a cryptic allosteric site involving three

225 sformation assays and expression analyses in mutants reveal that, in planta, the majority of these re

226 lysis of the lls1 sgl1 and lls1 palm1 double mutants revealed that SGL1 is epistatic to LLS1, and LLS

227 back, we now know that the analysis of these mutants revealed the molecular mechanisms and logic of t

228 ith normalized secretomes from wild-type and mutant S. marcescens derivatives.

229 ort inhibitors counteracted the CEP receptor mutant's steep GSA phenotype.

230 Here, through a genome-wide mutant screen of human antigen-presenting cells, we show

231 We found that multiple myc mutants share light-associated phenotypes with mutants o

232 Purified UNC-45B mutants showed changes in folding and solubility.

233 observed that rem1.2, orc1a, ppd1, and mcm4 mutants showed different degrees of reduction in rosette

234 tochondrial fission and mitochondrial fusion mutants showed increased sensitivity to osmotic stress a

235 2 (At1g65290), and mtACP3 (At5g47630) single mutants showed no discernible morphological growth pheno

236 h specific cellular potency for either WT or mutant SHP2.

237 homogenous population of transient P. patens mutants specific for our gene targets with zero survivin

238 d with the isocitrate dehydrogenase 2 (IDH2) mutant-specific inhibitor enasidenib, leading to improve

239 Preferential selection of the mutant splice site likely reflects its positioning adjac

240 Analysis of a zebrafish mutant, spondo, whose spine is dysmorphic, prompted us t

241 lacebo in patients with resected, BRAF(V600)-mutant, stage III melanoma in the phase 3 COMBI-AD trial

242 nt, hopper(Bd-we), isolated from a white eye mutant strain had an intact transposase reading frame an

243 dent growth of the M. smegmatis tam deletion mutant strain.

244 r cell signaling, and the germination of rpf mutant strains could not be stimulated by the addition o

245 We show that mutant strains lacking gigC have impaired growth in the

246 urement of the relative fitness of bacterial mutants, strains and species in mixed inocula in the hos

247 ty to recycle Snc1, but a snx4Deltarcy1Delta mutant substantially blocks export.

248 erosis (ALS), in which astrocytes expressing mutant superoxide dismutase-1 (mutSOD1) kill wild-type m

249 mmachc mutants survived the embryonic period but perished in ea

250 A Yersinia pestis mutant synthesizing an adjuvant form of lipid A (monopho

251 of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increa

252 -of-function fatty acid oxygenation 2 (fou2) mutant that, even when undamaged, shows JA-dependent lea

253 K) cleavage by SpoIVFB, based on analysis of mutants that bypass the need for relief of SpoIVFB inhib

254 can rapidly and comprehensively characterize mutants that have altered hypothalamic patterning, ident

255 ution of PTEN-null embryoid bodies with PTEN mutants that lack only PTEN's lipid phosphatase activity

256 Recombinant ZIKV mutants that lack ubiquitination are attenuated in human

257 Mutants that shorten SFs cause disoriented BBs.

258 ese results and freezing sensitivity of ost1 mutants, the cold-induced [Ca(2+) ](cyt) elevation in th

259 In cells transfected with FliI mutants, the LRR of FliI, but not its gelsolin-like doma

260 , but overexpression of dapF(Ct) allowed the mutant to overcome growth inhibition.

261 diting and engineered separation-of-function mutants to define how CENP-F contributes to kinetochore

262 m characterizing cancer-associated G-protein mutants to neurotransmitter signaling in primary neurons

263 regulatory function of most of the tested FH mutants to WT FH levels on a human HAP-1 cell line and o

264 We describe the isolation of a yeast top2 mutant (top2-F1025Y,R1128G) the product of which generat

265 ient mice, mAb treatment inhibited growth of mutant TP53, WT PTEN LN-229 tumors, and sensitized LN-22

266 in and tropomyosin showed weakening of actin-mutant tropomyosin binding.

267 ng could be beneficial to patients with KRAS-mutant tumors.

268 synthesis pathways, whereas OXPHOS(low) BAP1 mutant UM cells employ fatty acid oxidation.

269 cular analyses showed that OXPHOS(high) BAP1 mutant UM cells utilize glycolytic and nucleotide biosyn

270 By contrast, in an HLTF-HIRAN mutant, unrestrained replication relies on the TLS prote

271 architecture are minimally perturbed in Jag1 mutants until later stages, when ductal remodeling fails

272 sidues, followed by infection of the labeled mutant virions in mammalian cells in the presence of NAb

273 the replication and pathogenesis of the DUB mutant virus (DUBmut) in cultured macrophages and in mic

274 Although the mutant virus showed slightly decreased replication in mi

275 risk of the emergence of treatment-resistant mutant virus.

276 On the other hand, the two mutant viruses induced lower STAT1 phosphorylation and g

277 stigate the potential threat of serum escape mutant viruses to humans and poultry, the impact of thes

278 although the fitness characteristics of the mutant viruses were not fully defined.

279 To do this we screened the E90K GnRHR mutant vs. a library of 645,000 compounds using a cell-b

280 duced [Ca(2+) ](cyt) elevation in the ost1-3 mutant was reduced.

281 ar synthesis data from different strains and mutants, we identify the general underlying design princ

282 Furthermore, by imaging deletion mutants, we observed functional differences between the

283 und that the phenotypic changes of the dwarf mutant were associated with the physiological responses

284 The mutants were also affected in development as they produc

285 jmj14 mutants were compromised in both local and systemic defe

286 Three more FPGS mutants were identified in two patients, NT5C2 mutations

287 ies that of ISC1 Reciprocally, ISC1 deletion mutants were sensitive to benomyl, indicating a SAC defe

288 uration was also defective in the vps27Delta mutant, which had a larger vesicle size as measured by d

289 sensitive growth of the yeast mms19 deletion mutant while expression of the diminutive allele resulte

290 nalysis of the DLC1 mutants indicated 7 of 9 mutants whose lesions were located in the Rho-GAP domain

291 inear IgE epitopes, a hypoallergenic Ara h 2 mutant with abolished IgE binding and anaphylactogenic p

292 We generated an IL-10 mutant with enhanced affinity for its IL-10Rbeta recepto

293 eta counteracted the interference of D/N Vif mutants with A3G degradation by wild-type Vif.

294 m, besides Arabidopsis thaliana, with viable mutants with an essentially complete loss of methylation

295 Here we employ a series of mouse mutants with constitutive and conditional Sox10 deficien

296 nk between pathological localisation of ANKH mutants with different degrees in mineralization.

297 e, we describe the phenotype of 2 Cdk2 point mutants with elevated or decreased activity, respectivel

298 ions exhibit antibiotic tolerance, bacterial mutants with higher or lower tolerant subpopulation size

299 Phosphoproteomic comparison of TbDYRK null mutants with wild-type parasites identified molecules th

300 by Benjamin and colleagues demonstrates that mutant YAP expression is sufficient to enhance tumor cel

301 tovascular development in wild-type and etv2 mutant zebrafish embryos.