ライフサイエンスコーパス: mutant mouse

1 , and improved kidney function in the Arl13b mutant mouse.

2 of the cadherins is preserved in the reeler mutant mouse.

3 ance of CEACAM16, we created a Ceacam16-null mutant mouse.

4 ously proposed for the NMNAT2-deficient Blad mutant mouse.

5 vitro and in vivo in peripheral axons of the mutant mouse.

6 teoblast differentiation was impaired in the mutant mouse.

7 pansion, is down-regulated in the triallelic mutant mouse.

8 the colobomatous phenotype of the Foxg1(-/-) mutant mouse.

9 f severe forms of RASopathies, the KRAS(12V) mutant mouse.

10 utation in cell cultures and in the CNS of a mutant mouse.

11 P380), while denervation was frequent in the mutant mouse.

12 ities that are not observed in either single mutant mouse.

13 as almost completely abolished in the GluN2B mutant mouse.

14 e we studied the survival of RGCs in the rd1 mutant mouse, a known model of early onset, autosomic re

15 d a preneoplastic stage in the patched (ptc) mutant mouse, a model for the brain tumor medulloblastom

16 In this study, we utilized a targeted mutant mouse (Abcc6(-/-)) as a model system for PXE.

17 We now present a truncation mutant mouse allele, Specc1lDeltaC510, that results in p

18 The Traf3ip1 mutant mouse and cell lines will provide valuable resour

19 pecificity and is conserved between H3.3K27M-mutant mouse and human tumours.

20 combination of neutralizing antibody (nAb), mutant mouse and pharmacological approaches to test the

21 Anti-hypoallergenic Cyp c 1 mutant mouse and rabbit sera were tested for their abili

22 isease by generating a novel knock-in CaV1.1 mutant mouse and use this model to investigate the cellu

23 Using the c-Cbl RING finger mutant mouse as a model of a myeloproliferative disease

24 ploited the cytologically well-defined Prdm9 mutant mouse as a model of developmental arrest to test

25 We previously characterized the Enpp1(asj) mutant mouse as a model of generalized arterial calcific

26 We deep sequenced wildtype and Tbx5-mutant mouse atria, identifying 2600 novel Tbx5-dependen

27 ts as visual dysfunction in the heterozygous mutant mouse, B6;C3-Opa1(Q285STOP).

28 Homozygous Hpse2 mutant mouse bladders contained urine more often than di

29 mbryonic stem cells (ESCs) derived from Chd7 mutant mouse blastocysts as a tool to investigate roles

30 evated 20-carbon (C20) LCB production in the mutant mouse brain and eye, resulting in surprising neur

31 an autophagy marker, were also increased in mutant mouse brain as compared to wild-type mouse brain.

32 wild-type levels in the Cers2-rescued Cers1 mutant mouse brains.

33 migration was examined in a hypopmorphic C3G mutant mouse (C3G(gt)(/gt)) by using retrograde Dil labe

34 a cardiac-specific, tamoxifen-inducible MCUB mutant mouse (CAG-CAT-MCUB x MCM; MCUB-Tg) for in vivo a

35 Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in th

36 nt, a bispecific fusion protein comprising a mutant mouse CD80 (CD80w88a) and lymphocyte activation a

37 Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration

38 In fact, every genetically modifiedCbp mutant mouse characterized thus far exhibits impaired lo

39 induced mutagenesis, the identification of a mutant mouse (chompB) with a block in early B cell devel

40 xpression profiling in Apc-mutant and Ctnnb1-mutant mouse colon adenomas identified candidate genes f

41 synthesis and secretion of various SLRPs in mutant mouse corneas.

42 We evaluated two independent nsp15 mutant mouse coronaviruses, designated N15m1 and N15m3,

43 cantly decreased messenger RNA levels in the mutant mouse cortex are involved in myelination, and mut

44 FGF23 rescued the skeletal phenotype of this mutant mouse, creating an ideal in vivo model to study n

45 We generated a novel mutant mouse (Dclre1c(leaky)) that develops a LS phenoty

46 knockout are rescued by generating a double mutant mouse deficient for both PAP synthesis and hydrol

47 Moreover, a triple-mutant mouse deficient in the three C-type members of th

48 The Ttll5 mutant mouse develops slow photoreceptor degeneration wi

49 r-deficient phenotype observed in one Dfnb31 mutant mouse (Dfnb31(wi/wi)) suggest that DFNB31 may als

50 In the quakingviable (qk(v)) hypomyelination mutant mouse, diminished expression of isoforms of the s

51 Consistent with this, a Ttll5 mutant mouse displays a complete loss of RPGR glutamylat

52 However, the Ntn1 gene trap mutant mouse does not display all the phenotypes predict

53 and C) remain unknown, we generated a novel mutant mouse, dys-1A(-/-), with selective loss of dysbin

54 t for invasive tumor formation in Rb1 family mutant mouse embryo fibroblasts (MEFs).

55 e cullin3-based ubiquitin E3 ligase) in Sufu mutant mouse embryonic fibroblasts (MEFs) can restore th

56 Mechanistically, Tmem30a-mutant mouse embryonic fibroblasts (MEFs) exhibited dimi

57 Spry1(-/-) and Spry2(-/-) double mutant mouse embryonic fibroblasts exhibited decreased c

58 Consistent with this, a mutant mouse embryonic stem cell line with a deletion in

59 mination of Wnt pathway activities in Sestd1 mutant mouse embryonic tissue reveals disrupted PCP path

60 ded in the tooth bud mesenchyme in Osr2(-/-) mutant mouse embryos and is partially restored in the to

61 E12.5) and E13.5 Osr2(RFP/+) and Osr2(RFP/-) mutant mouse embryos and performed whole transcriptome R

62 function is confirmed by the fact that Brg1 mutant mouse embryos and RNAi knockdown cells exhibit a

63 s in tendon development were detected in the mutant mouse embryos as early as embryonic day 16.5 (E16

64 e-cell RNA-sequencing platform in which many mutant mouse embryos can be assayed simultaneously, reco

65 Snx3(-/-) mutant mouse embryos display a fully-penetrant cranial N

66 Surprisingly, Katnb1 null mutant mouse embryos display hallmarks of aberrant Sonic

67 t1l is an essential gene, as homozygous null mutant mouse embryos exhibit multiple developmental abno

68 vation-80% of Pax9(del/del);Wise(-/-) double-mutant mouse embryos exhibit rescued palatal shelf eleva

69 Hectd1 mutant mouse embryos exhibit the neural tube defect exen

70 studies showed that Robo1(-/-);2(-/-) double mutant mouse embryos have disruptions in both ventral an

71 Mutant mouse embryos lack primary cilia and, like talpid

72 Here, we examine the NMJs in mutant mouse embryos lacking either synaptobrevin 1 (Syb

73 Mutant mouse embryos lacking the heparan sulfotransferas

74 es invaded the floor plate of Robo1/2 double mutant mouse embryos or Slit1/2/3 triple mutants.

75 In Osr1 mutant mouse embryos, expression of Sox9 persisted in th

76 both sonic hedgehog(-/-) and in Zic2(kd/kd) mutant mouse embryos, providing further evidence that th

77 In Six3 conditional-mutant mouse embryos, specification of the neuroretina w

78 Neural derivatives of NC were lost in Foxd3 mutant mouse embryos, whereas abnormally fated NC-derive

79 ube and cardiac neural crest defects in Pax3-mutant mouse embryos.

80 , we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that

81 vessel networks favor interactions with Flt1 mutant mouse endothelial cells.

82 We constructed a homozygous mutant mouse ES cell line in the Traf2 gene that is know

83 Our strategy to generate null mutant mouse ES cells is applicable to thousands of gene

84 The HeCo mutant mouse exhibits subcortical band heterotopia (SBH)

85 Remarkably, the Pals1 mutant mouse exhibits the critical features of LCA such

86 FOB cells of the I-A(12%) mutant mouse express unfolded protein response and are e

87 Electroretinography showed mutant mouse eyes had a selective loss of the b-wave ind

88 Histological analysis of mutant mouse eyes showed protein extravasation from dila

89 ing the dominant-negative MyoVa neurological mutant mouse Flailer, we find that MyoVa plays an essent

90 eration of an analog-sensitive kinase allele mutant mouse for GSK3beta, we show that the beta isoform

91 use lines expressing wildtype (WT) and L151F mutant mouse GCAP1 with or without a C-terminal GFP fusi

92 This mutant mouse harbors a dominant-negative mutated thyroid

93 The Jimpy mutant mouse has a point mutation in the proteolipid pro

94 l of the left ventricle of RyR2 wild type or mutant mouse hearts.

95 Analysis of a heterozygous mutant mouse in which the NF-kappaB-dependent IkappaB al

96 r 2 (eEF2), we generated an eEF2 Gly(717)Arg mutant mouse, in which the first step of diphthamide bio

97 ury, protamine sulfate perfusion of the Cfl1 mutant mouse induced a broadened and flattened foot proc

98 The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a ge

99 We found that in Pkd1 conditional mutant mouse kidneys, neither downregulation nor activat

100 target genes are also increased in HNF-1beta mutant mouse kidneys.

101 ar development by generating a conditionally mutant mouse lacking endothelial p120 and determining th

102 Using a loss-of-function mutant mouse lacking the guanylate kinase domain of PSD-

103 A complementary mutant mouse lacking the transactivation function AF-2 o

104 A new mutant mouse (lamb1t) exhibits intermittent dystonic hin

105 on in humans and in retinal degeneration rd7 mutant mouse leads to increased S-cones accompanied by r

106 We screened an ethyl nitrosourea mutant mouse library for IMPase gene (Impa) mutations an

107 Like talpid(3) chicken limbs, the mutant mouse limbs are syndactylous with uneven digit sp

108 In this report, we describe the mutant mouse line 20884, generated by N-ethyl-N-nitrosou

109 racterized the in vivo roles of Rex1 using a mutant mouse line disrupting its transcription.

110 ing carcinogenesis in vivo, we subjected the mutant mouse line Dsk5, in which the intrinsic activatio

111 The flatiron (ffe) mutant mouse line harbors a hypomorphic mutation in Fpn1

112 nt study, this prediction was tested using a mutant mouse line lacking this potential imprinting cont

113 servations indicate that our novel profilin1 mutant mouse line may provide a new ALS model with the o

114 mice from the N-ethyl-N-nitrosourea-induced mutant mouse line nur5 display tremor and an abnormal ga

115 To evaluate this possibility, a Traf3ip1 mutant mouse line was generated.

116 Here, we studied a novel mutant mouse line, in which the projections from the bra

117 Using a sex-reversing mutant mouse line, we show that innervation is specific

118 hat co-segregated with cleft palate in a new mutant mouse line.

119 lyze 118 neuroanatomical parameters in 1,566 mutant mouse lines and identify 198 genes whose disrupti

120 either DAT- or D1R-expressing neurons in our mutant mouse lines by colocalization studies.

121 Founders of the mutant mouse lines developed DCM with severe heart failu

122 Both of these mutant mouse lines developed hepatic steatosis and subse

123 b portal provide access to information about mutant mouse lines held as live or cryopreserved stocks

124 We generated four novel mutant mouse lines in which BDNF production from one of

125 li and relapse behavior using four inducible mutant mouse lines lacking the glutamate receptor genes

126 Screening of multiple mutant mouse lines revealed that haploinsufficiency of D

127 a subunit expression is perturbed, we used 4 mutant mouse lines that each lack a specific beta subuni

128 Here we show the results of screening 810 mutant mouse lines using an in vivo assay to identify mi

129 rformed a forward genetic screen to identify mutant mouse lines with heritable CHD.

130 Analysis of several induced mutant mouse lines with ocular disease phenotypes reveal

131 hyperbilirubinemia in two independent Atp11c mutant mouse lines, and find that it originates from an

132 study of the EPR in unlimited transgenic and mutant mouse lines, and for an unprecedented exploration

133 ight control in vivo, we generated two novel mutant mouse lines, including a constitutive NEGR1-defic

134 Analysis of several Isl1 mutant mouse lines, including animals harboring an SAN-s

135 Here, we have characterized two mutant mouse lines, one lacking calcium and integrin-bin

136 Similar to previously characterized Cln3 mutant mouse lines, this novel model shows pathological

137 e the prevalence of this mutation in induced mutant mouse lines, vendor C57BL/6 mice and in widely us

138 In analyzing axon regeneration in different mutant mouse lines, we discovered that deletion of suppr

139 ection (FS) LacZ staining in 313 unique KOMP mutant mouse lines.

140 mitochondrial transport was affected in both mutant mouse lines.

141 approaches, respectively, from a set of 2082 mutant mouse lines.

142 his present study, we have generated an Mdm2 mutant mouse (Mdm2(Y393F)) to determine whether c-Abl ph

143 In this study, an Mecp2 truncation mutant mouse (Mecp2(308)) with social behavioral defects

144 ase phenotype, we generated an inducible Atm mutant mouse model (Atm(tm1Mmpl/tm1Mmpl), referred to as

145 Using a mutant mouse model (Beethoven) for progressive hearing l

146 We generated a PLN-deficient, RyR2-mutant mouse model (PLN-/-/RyR2-R4496C+/-) by crossbreed

147 Herein we utilized both our Kras/p53 mutant mouse model and human lung cancer cell lines to d

148 imary myoblasts and fibroblasts from an FKRP mutant mouse model and that this enhancement is abrogate

149 ificance of CBFs, we generated a conditional mutant mouse model in which granulosa cell expression of

150 particular, astrocytes derived from the SOD1 mutant mouse model of ALS or from human familial or spor

151 tor neurons from cell death in the G93A-SOD1 mutant mouse model of amyotrophic lateral sclerosis (ALS

152 Here, we utilized the Shank3B mutant mouse model of autism to investigate how Shank3 m

153 ng a monoclonal anti-IL6 antibody in a K-ras-mutant mouse model of lung cancer in the absence or pres

154 Here we present a mutant mouse model of OCCC.

155 drug-targeting efficacy in a transgenic p53-mutant mouse model of pancreatic cancer.

156 In a conditional Tp53;Rb1 mutant mouse model of SCLC, we now demonstrate a require

157 In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA deficiency

158 rproliferation by statins in an Apc/KrasG12D-mutant mouse model was independent of de novo pyrimidine

159 The I-A(12%) mutant mouse model we describe in the present study is a

160 ors (an mGluR5 NAM and PAM) for TSC, using a mutant mouse model with neuronal loss of Tsc2 that demon

161 t of the target genes are also affected in a mutant mouse model with reduced levels of PEG3 protein.

162 Here we report the first Jbts17 mutant mouse model, Heart Under Glass (Hug), recovered f

163 ome 8, as exemplified by the Fused Toes (Ft) mutant mouse model, results in severely decreased number

164 the NUP98-HOXD13 (NHD13) mouse and the RUNX1 mutant mouse model.

165 SCs) isolated from mammary tumors of a Brca1-mutant mouse model.

166 es were made possible by recovery of a Wdpcp mutant mouse model.

167 he CHD2 in mammals, we have generated a Chd2 mutant mouse model.

168 ght axis establishment in embryos of a Dnah5 mutant mouse model.

169 on factor in development of this region in a mutant mouse model.

170 d survival caused by elevated cGMP in a PDE6 mutant mouse model.

171 of co-expressed WT-hSOD1 in two established mutant mouse models (L126Z and G37R), and a new model th

172 tent across three very different types of HD mutant mouse models (YAC128, Q175, R6/2).

173 dimensional IHBD structure using a series of mutant mouse models and a resin casting method.

174 As we discuss here, mutant mouse models and clinical evidence indicate that

175 pendent increase in gene expression in MeCP2 mutant mouse models and human RTT brains.

176 ctivity and renal cystic disease in two Pkd1-mutant mouse models at different stages of the disease.

177 evious work using viral gene therapy on PDE6-mutant mouse models demonstrated photoreceptors can be r

178 Using mutant mouse models for the most common form of congenit

179 Using mutant mouse models for the most common form of congenit

180 The study of human genetic disorders and mutant mouse models has provided evidence that genome ma

181 Availability of multiple lines of Cx-mutant mouse models has provided some insight into the p

182 Further, we examine how p53 mutant mouse models have been used to test the efficacy

183 Mutant mouse models have identified Fbxo11, Evi1, Tgif1,

184 dney scar formation, we used two conditional mutant mouse models in which Twist1 was selectively abla

185 ges not observed previously in other genetic mutant mouse models of co-morbid cognitive and autistic-

186 3 function in cancer cells derived from KRAS-mutant mouse models of PDAC leads to the accumulation of

187 Previous studies in myelin-mutant mouse models of the inherited and incurable nerve

188 Ins2 mutant mouse models provided important insights into the

189 This collection of mutant mouse models provides a resource for further stud

190 As existing JS/MKS mutant mouse models suggest apparently contradictory hyp

191 lyzed KrasG12D;Cyp19-Cre and KrasG12;Pgr-Cre mutant mouse models that express Cre prior to or after t

192 Here, we used Pkd1 mutant mouse models to demonstrate that the nicotinamide

193 rometry was applied to tissues from targeted mutant mouse models to explore the collagen substrate sp

194 Here, we leveraged a cohort of 13 lncRNAnull mutant mouse models to investigate the spatiotemporal ex

195 for CNV formation by generating a series of mutant mouse models with induced conditional deletion of

196 The present study generated 3 mutant mouse models with truncated C termini in 2 differ

197 disease progression in spinal cord from SOD1-mutant mouse models, and reductions in membralin/EAAT2 w

198 In genetic Apc-mutant mouse models, loss of Prox1 promoted the growth o

199 exposed to oligomeric Abeta in vitro and APP mutant mouse models, modulation of p75(NTR) signaling us

200 ngs in wild type, transgenic and combination mutant mouse models, suggesting either activity-dependen

201 extensive phenotypic overlap with our Foxc1 mutant mouse models, validating our DWM models and demon

202 By targeting molecules in pfGCs with several mutant mouse models, we demonstrate that the somatic pfG

203 h additional Rptor, Rictor, and Rptor/Rictor mutant mouse models, we identify mechanistic target of r

204 Using Col4a1 and Col4a2 mutant mouse models, we investigated the genetic complex

205 uman phenotype can be recapitulated in Cwc27 mutant mouse models, with significant embryonic lethalit

206 widely adopted to generate a large number of mutant mouse models.

207 cleft palate in both existing and new Esrp1 mutant mouse models.

208 lstrom syndrome, as well as in several cilia mutant mouse models.

209 r development in vivo, we generated specific mutant mouse models.

210 cancer incidence as often seen in other p53-mutant mouse models.

211 t in infertility and predisposes to tumor in mutant mouse models.

212 maintenance using congenital and conditional mutant mouse models.

213 nses were defined and verified using various mutant mouse models.

214 present study, we have studied three new Rs1 mutant mouse models: (1) a knockout with inserted lacZ r

215 To investigate the in vivo function of Gba1 mutants, mouse models were generated by backcrossing the

216 Micro-CT analysis of Enpp1 mutant mouse molars revealed 4-fold increased acellular

217 We generated a targeted mutant mouse, nBmp2NLS(tm), in which the nuclear localiz

218 n MHC-II, we established a novel ENU-induced mutant mouse on the C57BL/6 background, named I-A(12%),

219 Loss of full-length RIM2alpha in a RIM2alpha mutant mouse only marginally perturbs photoreceptor syna

220 RNA-seq analysis of mutant mouse ovaries collected at 11 h post-hCG unveiled

221 The Glis3(zf/zf) mutant mouse pancreas shows a dramatic loss of beta and

222 ly restore islet development in Neurog3-null mutant mouse pancreata.

223 from analyses of ABL structure-function, ABL mutant mouse phenotypes, and ABL substrates suggest that

224 Pit-1 and increased Lef-1 expression in the mutant mouse pituitary, consistent with the repression o

225 fibroblasts from the long-lived Snell dwarf mutant mouse, previously shown to be resistant to many t

226 Repro22 is a mutant mouse produced via N-ethyl-N-nitrosourea-induced

227 NAC treatment decreased ROS levels in Nkx3.1 mutant mouse prostates, it failed to reduce prostatic ep

228 The Lmna(Dhe/+) mutant mouse provides a novel model of human OM and lami

229 We show that PHD mutant mouse Rag2 proteins that correspond to those foun

230 Using the Cep290 mutant mouse rd16 (retinal degeneration 16), we show tha

231 EGFP reporter mice are available through the Mutant Mouse Regional Resource Center (NINDS/GENSAT coll

232 hrough c-MYC in embryonic and postnatal Pkd1-mutant mouse renal epithelial cells and tissues and coul

233 We found that Brd4 was upregulated in Pkd1 mutant mouse renal epithelial cells and tissues.

234 their therapeutic potential in the FKRPP448L-mutant mouse representing moderate limb-girdle muscular

235 The mutant mouse represents a valuable model to further eluc

236 The Dscam mutant mouse retina also exhibits excess numbers of thes

237 d cone photoreceptor CREs from wild-type and mutant mouse retinas, defined by presence or absence, re

238 increase in long-chain fatty acids in BMPR2 mutant mouse RVs compared with controls, which correlate

239 e shown that a phosphorylation defective RyR mutant mouse (RyRS2808A) does not respond normally to sy

240 We find that the homozygous nervous (nr) mutant mouse's 10-fold-increased cerebellar tissue plasm

241 sion of Cdk2ap1 or a nonphosphorylatable pRb mutant (mouse Ser(788) --> Ala), suggesting that the CDK

242 The new mutant mouse shaking (shk) differs from other "myelin mu

243 Here we show that hypomorphic mtFAS mutant mouse skeletal myoblast cell lines display a seve

244 milarities to a previously identified ZAP-70 mutant mouse, SKG, which harbors a distinct hypomorphic

245 About 20%-30% of Hras mutant mouse skin carcinomas induced by chemical initiat

246 The glycine receptor-deficient mutant mouse spastic carries a full-length long interspe

247 tion, and thus used the serine racemase-null mutant mouse (SR(-/-)), which has less than 10% of norma

248 We generated a mutant mouse strain carrying an F832A mutation in Rb1 th

249 ed a forward genetics approach to identify a mutant mouse strain characterized by the absence of CNS

250 This mutant mouse strain provides a unique model to further e

251 We show that a CRD-BP mutant mouse strain retains expression of the shorter tr

252 er (EOC) in vivo We used the Pten/Kras(G12D)-mutant mouse strain that develops serous EOC with 100% p

253 Surprisingly, our studies of a knock-in mutant mouse strain that expresses a stabilized and tran

254 We generated a mutant mouse strain that lacks exons 13-20 of L3mbtl1.

255 in individual hippocampi from the mast cell mutant mouse strain, C57BL/6 Kit(W-sh/W-sh).

256 Here we describe a novel mutant mouse strain, Goldenticket (Gt), that fails to pr

257 A conditional mutant mouse strain, in which Pitx2 function is inactiva

258 ing a CPT1 blocker or by using a Cpt1a P479L mutant mouse strain.

259 generated a cleavage-resistant Ripk1(D325A) mutant mouse strain.

260 Mutant mouse strains deficient in RGS7 or -11 were chara

261 Compared with wild-type mice, 2 FHM1 mutant mouse strains developed earlier onset of anoxic d

262 Studies of mutant mouse strains have revealed that each family memb

263 The fast accumulation of mutant mouse strains in recent years has provided an inv

264 Mutant mouse strains with "autistic-like" phenotypes (Fm

265 e-driven breast tumorigenesis in a series of mutant mouse strains with specific DDR deficiencies to r

266 he DFI of frozen-thawed sperm from 83 unique mutant mouse strains with sperm count, motility and morp

267 Using several mutant mouse strains, immunoblotting, and microcomputed

268 ked compositional differences between WT and mutant mouse strains.

269 ele of Dscam to use alongside existing Dscam mutant mouse strains.

270 On the basis of our mutant mouse study, we suggest that PCP pathway mutation

271 nd netosis in neutrophils, thereby enhancing mutant mouse survival against systemic infection with a

272 tion of an Lpar1(flox/flox) conditional null mutant mouse that allows for cre-mediated conditional de

273 We have also investigated a spontaneous mutant mouse that expresses a truncated MAP7 and found a

274 Here we characterize a Col6a3 mutant mouse that expresses a very low level of a non-fu

275 r, previous genetic studies employed an RGS7 mutant mouse that is hypomorphic, and hence the exact ro

276 Here, we generate the Sting1(S365A/S365A) mutant mouse that precisely ablates IFN-dependent activi

277 Here, we have described a mutant mouse that spontaneously develops pruritic dermat

278 ical development suggest that, in the reeler mutant mouse, the lack of the protein Reelin results in

279 We generated a Tim-1-mutant mouse (Tim-1(Deltamucin)) in which the mucin doma

280 erapeutic, converted the mild C3 GN of an fH-mutant mouse to a lethal C3 GN with features of human de

281 We used a genetic model of PAH, the Bmpr2 mutant mouse, to study the role of BM-derived circulatin

282 We used a thyroid hormone receptor (TR) beta mutant mouse (TRbetaPV) to establish the relevance of th

283 The histopathologic features of the triple-mutant mouse tumors closely resembled that of human SCLC

284 experiments further showed that Rb/p53/p130-mutant mouse tumors were similar to human SCLC.

285 In 2008, another ERbeta mutant mouse was generated by deleting ERbeta exon 3 whi

286 d cAMP-regulated phosphoprotein 32) knock-in mutant mouse was generated to analyze the role of DARPP-

287 Using a CaMKIV null mutant mouse, we demonstrate that a loss of CaMKIV prote

288 Using the ciliopathic Fuz mutant mouse, we find that high arched palate does not,

289 nsgenic gene replacement strategy in a Pitx1 mutant mouse, we have uncoupled two discrete functions o

290 ically older archicortex of the adult reeler mutant mouse, we studied the expression of 11 different

291 RGS11 protein remained unchanged in the RGS7 mutant mouse, where a truncated RGS7 protein was express

292 unit expression were decreased in the Dicer1 mutant mouse, whereas proopiomelanocortin and luteinizin

293 between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene,

294 our investigation, we used the Smad1/5(CKO) mutant mouse, whose disorganized growth plate is due to

295 edicts a shift in simple spike activity in a mutant mouse with a brainstem specific mutation.

296 Using a Hgf mutant mouse with a small 10 bp deletion recapitulating

297 n mu opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P4

298 king a forward genetic screen, we isolated a mutant mouse with defects in interneuron migration.

299 ounds with strong efficacy in a B-Raf(V600E) mutant mouse xenograft model.

300 e scaffolding function, we generated a zap70 mutant mouse (YYAA mouse) with Y315 and Y319 both mutate