ライフサイエンスコーパス: mutant phenotype

1 th the downstream kinase cascade rescued the mutant phenotype.

2 ORRM6 rescues the orrm6 editing defects and mutant phenotype.

3 tic vesicle TA proteins explains much of the mutant phenotype.

4 ectopic WUS expression as a component of the mutant phenotype.

5 reducing Fgf10 dosage can attenuate the Etv mutant phenotype.

6 n, inhibition of SPT was able to reverse the mutant phenotype.

7 at disrupt Ubx expression, leading to the bx mutant phenotype.

8 haracterised Oakleaf, a novel S locus-linked mutant phenotype.

9 -type mRNAs partially suppresses the rbm25-2 mutant phenotype.

10 monstrating that ZmFNSI-1 can complement the mutant phenotype.

11 for two copies of the allele will display a mutant phenotype.

12 Injected human wt ZC4H2 rescued the mutant phenotype.

13 loss of these activities can explain the mwh mutant phenotype.

14 oxidase activity partially complemented the mutant phenotype.

15 silencing of which partially rescues the stf mutant phenotype.

16 one of the most conspicuous features of the mutant phenotype.

17 f this approach to the detection of a subtle mutant phenotype.

18 nce in these neurons, recapitulated the FoxP mutant phenotype.

19 and suppresses the gain-of-function bzr1-1D mutant phenotype.

20 W-boxes are essential for rescue of the try mutant phenotype.

21 cellular, and transcriptomic analyses of the mutant phenotype.

22 The transgenes completely rescued the cftr mutant phenotype.

23 le TDOR, SdbA, which exhibited a pleiotropic mutant phenotype.

24 Sustained exogenous FGF failed to rescue the mutant phenotype.

25 d protein in strains that suppress the Clock mutant phenotype.

26 v levels significantly suppressed the worniu mutant phenotype.

27 etion of Trm112 results in a bud23Delta-like mutant phenotype.

28 or LUX ARRHYTHMO (LUX) complements the elf4 mutant phenotype.

29 ibition, which molecularly recapitulated the mutant phenotype.

30 he precursor chorismate, also suppressed the mutant phenotype.

31 man SLC16A6 in rmn mutant livers rescues the mutant phenotype.

32 ereas SlGLK2 suppression recapitulated the u mutant phenotype.

33 d transcripts may contribute to the observed mutant phenotype.

34 alloproteinase 13 inhibitor, ameliorated the mutant phenotype.

35 subset of tissues but does not mimic the Gr mutant phenotype.

36 e), and activated AMPKalpha rescued the sgt1 mutant phenotype.

37 rors, but does not further enhance, the idn2 mutant phenotype.

38 lts in AL defects that recapitulate the Orco mutant phenotype.

39 ssion to the vasculature did not improve the mutant phenotype.

40 cumulation did not appear to mediate the ETC mutant phenotype.

41 ic agonists, potentially correcting this LOF mutant phenotype.

42 elated with their ability to rescue the mum2 mutant phenotype.

43 ith human EXOC5 mRNA completely reversed the mutant phenotype.

44 ecific manner, which may explain the complex mutant phenotype.

45 of BASS6 complemented this photorespiration mutant phenotype.

46 lains the aetiology of the even-skipped null mutant phenotype.

47 al region of SS4 alone did not alter the ss4 mutant phenotype.

48 a a genetic screen for enhancers of the rhd3 mutant phenotype.

49 Edn3 expression rescued the homozygous white mutant phenotype.

50 pharynx, and its transgene rescues the sms-1 mutant phenotype.

51 a survival advantage conferred by the FAM46C mutant phenotype.

52 H2 O2 ) in myb36-5 significantly rescues the mutant phenotype.

53 d cause salicylic acid- and EDS5-independent mutant phenotypes.

54 es in which loss-of-function alleles produce mutant phenotypes.

55 ere it is now possible to identify genes for mutant phenotypes.

56 e it recapitulates expected loss-of-function mutant phenotypes.

57 ed to recapitulate the single or double null mutant phenotypes.

58 ation with DAO1pro:YFP-DAO1 complemented the mutant phenotypes.

59 s was sufficient to rescue their S-dependent mutant phenotypes.

60 17L (GATA17-LIKE), based on loss-of-function mutant phenotypes.

61 henotypes for genes with previously reported mutant phenotypes.

62 confers defects concordant with rec8 phospho-mutant phenotypes.

63 ains and investigated the suppression of the mutant phenotypes.

64 orrespond to severe loss of function or null mutant phenotypes.

65 roviding a possible mechanism to explain Pvr mutant phenotypes.

66 ramework for interpreting plant genetics and mutant phenotypes.

67 rexpression is able to rescue several parkin-mutant phenotypes.

68 networks compared with genes with nonlethal mutant phenotypes.

69 romoter interactions could partially explain mutant phenotypes.

70 ocalization, in combination with analysis of mutant phenotypes.

71 to the outer kinetochore rescues ndc80-NH12-mutant phenotypes.

72 ividual type III LTPs produced no observable mutant phenotypes.

73 reas RAB7L1 overexpression rescued the LRRK2 mutant phenotypes.

74 ed their ability to rescue arr1 arr12 double mutant phenotypes.

75 ion in trans partially or fully restored the mutant phenotypes.

76 and ATR kinases in several MRN-dependent E4 mutant phenotypes.

77 o experimental observations of wild type and mutant phenotypes.

78 erally similar to previously reported CaMKII mutant phenotypes.

79 ly and efficiently map genes responsible for mutant phenotypes.

80 ur simple model can suggest explanations for mutant phenotypes.

81 urotransmission and does not suppress unc-17 mutant phenotypes.

82 aracterized gene with no previously reported mutant phenotypes.

83 phila larval brains, comparing wild-type and mutant phenotypes.

84 he ability to generate progeny with expected mutant phenotypes.

85 ables more refined morphological analysis of mutant phenotypes.

86 tations in lug and an3 enhanced each other's mutant phenotypes.

87 X expression and lacked dosage-compensation mutant phenotypes.

88 OMAIN29 (LBD29) is responsible for the fls-d mutant phenotypes.

89 nt suppressors of morc-1(-) and nuclear RNAi mutant phenotypes.

90 s reasonable behaviour of control as well as mutant phenotypes.

91 overexpression largely recapitulated the Myt-mutant phenotypes.

92 ridis and screened for visible inflorescence mutant phenotypes.

93 agonistically affect the alpha Aurora double mutant phenotypes.

94 8 gene dosage is sufficient to suppress den1 mutant phenotypes.

95 alances that are not uncovered from deletion-mutant phenotyping.

96 Consistent with the rapid-flowering mutant phenotype, a range of genes involved in floral in

97 led that resveratrol could ameliorate dnj-14 mutant phenotypes, an effect mimicked by the cAMP phosph

98 using a combination of approaches, including mutant phenotype analyses and chromatin immunoprecipitat

99 Mutant phenotype analysis of bacteria has been revolutio

100 Notably, ITK inhibitors mimic the null mutant phenotype and also prevent pancreatic islet infil

101 onal complementation of the non-ripening rin mutant phenotype and caused fruits to ripen.

102 The mutant phenotype and gene identities suggest that NKD co

103 escue the Arabidopsis max1-1 highly branched mutant phenotype and increase the production of the SL,

104 Relationships between mutant phenotype and protein function, genetic redundanc

105 Here we dissected this ridA mutant phenotype and showed it was an indirect consequen

106 This mutant phenotype and the absence of galacturonic acid in

107 nsemble, and selected a model that predicted mutant phenotypes and connections between evening-phased

108 blmp-1 deletion suppressed dre-1 mutant phenotypes and exhibited developmental timing def

109 e explanation for these observations is that mutant phenotypes and fitness may depend upon the specif

110 We use existing mutant phenotypes and fluorescence data to parameterize

111 Typically, it considers single and double mutant phenotypes and for a pair of genes observes wheth

112 lia mutants; however, spatial restriction of mutant phenotypes and lack of left-right patterning defe

113 The mutant phenotypes and localization of him-5 are similar

114 Mutant phenotypes and modeling support an assembly model

115 This proposal is supported by mutant phenotypes and other results indicating that the

116 aspects of Lhx6(-)/(-) cell-fate and laminar mutant phenotypes and provide insight into a neonatal ro

117 efects alter previous interpretations of the mutant phenotypes and provide new insights into the mole

118 his may lead to a better understanding of Rb mutant phenotypes and Rb's roles in oncogenesis.

119 copy of ballchen or l(2)gl suppresses Ankle2 mutant phenotypes and restores viability and brain size.

120 The pore structure explains important mutant phenotypes and suggests that the double beta-barr

121 NsWOX9 ectopic expression enhances the lam1 mutant phenotype, and antisense expression partially res

122 itional neural tubes mirroring the embryonic mutant phenotype, and chemical modulation could induce e

123 mmunofluorescence analysis characterized the mutant phenotype, and lineage analysis tested whether Ca

124 as found to cosegregate with a short petiole mutant phenotype, and thus may serve as an example of a

125 Transformation with D1bLIC-GFP rescues the mutant phenotypes, and D1bLIC-GFP assembles into the dyn

126 vegetative tissues partially rescued ala4/5 mutant phenotypes, and expression of ALA4 transgenes in

127 s been hampered by the lack of corresponding mutant phenotypes, and the role of imprinting is mainly

128 pals-22 mutant phenotypes appear independent of the well-studied

129 Drosophila Adar(5G1) mutant phenotypes are ameliorated by feeding GABA modula

130 Mutant phenotypes are associated with gene information.

131 TF knockout mutant phenotypes are consistent with model predictions.

132 Cellular mutant phenotypes are consistent with the observed trans

133 Several Fbxw7 mutant phenotypes are due to dysregulation of mTOR; howe

134 nthetic lethality in which hlh-1 and unc-120 mutant phenotypes are mutually buffered by joint additiv

135 However, it has long been documented that mutant phenotypes are not a simple result of a single DN

136 on-induced genes with no previously reported mutant phenotypes are required for timely spore maturati

137 Finally, the pcf11-13 and sen1-1 mutant phenotypes are very similar, as both accumulate R

138 ed for male fertility and has the same basic mutant phenotype as spe-45.

139 e that were subject to recurrent screens for mutant phenotypes as the mice aged.

140 plications for interpreting the cause of any mutant phenotype, assigning gene function, and genetical

141 Mutant phenotypes associated with decreased activity of

142 nsgenes could rescue the loss-of-function er mutant phenotype at both morphological and cellular leve

143 Based on these results, we suggest that mutant phenotypes become the standard metric to define g

144 heart field development not only rescues the mutant phenotype, but also is sufficient for proper func

145 for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss

146 Complementation of the DeltaacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase f

147 Suppression of the rne mutant phenotype by inactivation of deaD was partial, as

148 pression partially phenocopies the mir-35-42 mutant phenotype by inducing embryonic lethality and low

149 and pharmaceutical partial rescue of the Sp8 mutant phenotype by reducing Sonic Hedgehog (SHH) signal

150 P deletion partially rescues the bvht(dAGIL) mutant phenotype by restoring differentiation capacity.

151 ntation of ohp1 mutants and induction of the mutant phenotype by theophylline.

152 ors (NAMs) has been shown to ameliorate many mutant phenotypes by correcting excessive protein synthe

153 Rescue of unc-13/Munc13 mutant phenotypes by overexpressed open UNC-64/syntaxin

154 and transposon alleles of drl2 enhance drl1 mutant phenotypes by reducing floral meristem (FM) deter

155 nt approach for producing mice with compound mutant phenotypes, bypassing constraints of conventional

156 These mutant phenotypes can be rescued by expressing wild-type

157 All edr1 mutant phenotypes can be suppressed by missense mutation

158 These mutant phenotypes cannot be rescued by neuron-specific i

159 Mutant phenotypes caused by the inactivation of genes en

160 The mutant phenotypes closely resemble those associated with

161 genes were knocked down, also showed the nkd mutant phenotype, confirming the gene identities.

162 den) abolished mRNA rescue of the respective mutant phenotypes, consistent with their known contribut

163 14 mRNA; however, the conditional pale-green mutant phenotype contrasts with the normal growth of the

164 embrane of mitochondria complements the pen2 mutant phenotype, corroborating the functional importanc

165 AHH1) during early seedling development when mutant phenotypes could be clearly observed.

166 Its features are joint treatment of the mutant phenotype data with a factorized model and probab

167 n improved quantitative framework to analyze mutant phenotypes, detect symmetry-breaking events in ti

168 The topB mutant phenotype did not result from accumulation of tox

169 ermis development, but lacking a single-gene mutant phenotype due to genetic redundancy.

170 3935 gene leads to complete recovery of dosR mutant phenotypes during hypoxia.

171 type C. elegans, uncovers previously unknown mutant phenotypes, efficiently tracks changes in aging p

172 Moreover, PRC mutant phenotypes emerge after gross epigenetic and tran

173 The mutant phenotypes exhibit dominant inheritance, but inco

174 mtbri1 mutants displayed characteristic bri1 mutant phenotypes: extreme dwarfness, dark green curled

175 as assessed by its ability to suppress yeast mutant phenotypes for both metals.

176 in improving the ability to detect putative mutant phenotypes from post-hoc analysis of large data s

177 OGTs that did not fully rescue the deletion mutant phenotypes had reduced or no activity.

178 Distinct expression patterns and mutant phenotypes, however, reveal that Sox11 and Sox4 a

179 The ron3-1 and ron3-2 mutant phenotypes [i.e., reduced apical dominance, prima

180 A screen for mutants that mimic the hira-1 mutant phenotype identified PQN-80-a HIRA complex compon

181 n tan1 air9 significantly rescued the double mutant phenotype in all three respects.

182 tivity is still able to complement the atd14 mutant phenotype in an SL-dependent manner.

183 ty and enhances the supernumerary neuroblast mutant phenotype in brat mutant brains.

184 The severity of the Pol-gamma mutant phenotype in heterozygous diploid humanized yeast

185 types are opposite to the known class II TCP mutant phenotype in JAW plants.

186 apst1 PAPST1 failed to complement the papst2 mutant phenotype in mitochondria, because it likely remo

187 TAN1-DeltaII-YFP, significantly rescued the mutant phenotype in terms of root growth and division pl

188 STF also complements the lfl mutant phenotype in the flower if expressed under the LF

189 a reporter fusion and complementation of the mutant phenotype in vivo.

190 The mutant phenotypes in biomass and flowering time suggeste

191 male meiosis produce kernels with concordant mutant phenotypes in both endosperm and embryo because t

192 we show that MUL1 suppresses PINK1 or parkin mutant phenotypes in Drosophila.

193 mev-1::miniSOG transgene complemented mev-1 mutant phenotypes in kn1 missense and tm1081(lf) deletio

194 Human clinical traits and aberrant mutant phenotypes in laboratory organisms are not includ

195 Here we show that the yki mutant phenotypes in multiple developmental contexts are

196 consistent with the observation that B3GLCT mutant phenotypes in PPS patients are less severe than e

197 splice site morphants showed various ciliary mutant phenotypes in these organs.

198 ng compensatory mutations, we alleviated the mutant phenotypes in two of these cases, one of which we

199 xpression of SLP-2 transgenes rescued parkin mutant phenotypes, in particular loss of dopaminergic ne

200 icate a significant functional rescue of the mutant phenotype (including re-assembly of Complex V) fo

201 uncover the underlying genes for 44 of these mutant phenotypes, including 12 late-onset phenotypes.

202 ssion of KCS1 in akr2a mutants rescued akr2a mutant phenotypes, including chilling sensitivity and a

203 rison of Efnb2 and Notch signaling-deficient mutant phenotypes indicated that these two signaling sys

204 S1 was not able to complement the tomato rin mutant phenotype, indicating AcMADS1 may not be a functi

205 s1 mutants, and application of B rescues the mutant phenotype, indicating that the TLS1 protein facil

206 The mutant phenotype is also temperature-sensitive.

207 and transgenic experiment, we show that the mutant phenotype is caused by a dominant-negative mutati

208 lino oligonucleotides confirmed that the ecl mutant phenotype is caused by down-regulation of sp8.

209 This dysbindin mutant phenotype is fully rescued by presynaptic express

210 similar to PEX11 in other organisms but the mutant phenotype is more extreme and environmentally det

211 However, we found that the amp1 mutant phenotype is only partially corrected by elevated

212 The uox mutant phenotype is suppressed in a xanthine dehydrogena

213 As the mutant phenotype is unique, with RGI production only imp

214 We show that the induction of the zim17 mutant phenotype leads to strong import defects for Ssc1

215 The collection of mutant-phenotype mapping provides a framework for engine

216 ir potential to aid in the discrimination of mutant phenotypes masked by alterations in growth.

217 ults prompted us to ask whether neuroligin-3 mutant phenotypes may be reshaped by developmental plast

218 Creating and analyzing mutant phenotypes may therefore become rate-limiting in

219 several DELLA proteins suppressed the det1-1 mutant phenotype more obviously than GA treatment, indic

220 report a novel aspect of the documented Tbx6 mutant phenotype, namely an increase from two to four ec

221 Many of the mutant phenotypes observed were contingent upon the pres

222 90BRhoGAP impairs RhoB inactivation, and the mutant phenotype of patient-derived ECs is replicated by

223 Attenuation of glycolysis rescued the mutant phenotype of premature cartilage maturation, ther

224 st this possibility further, we analyzed the mutant phenotype of the zebrafish kif3a gene, which enco

225 kcross into the maize inbred line PH09B, the mutant phenotype of vyl lasted much longer in the greenh

226 Our experiments demonstrated that mutant phenotypes of CSAS are similar to those of DSiaT,

227 Finally, the mutant phenotypes of DeltaPpXLG and DeltaPpGbeta2 can be

228 Mutant phenotypes of hypersensitivity to drought and few

229 We found that the mutant phenotypes of prc1-1, a cesa6 null mutant, were r

230 ools will facilitate the rapid evaluation of mutant phenotypes of specific genes and the precise modi

231 In support of this, many mutant phenotypes of the pil1 lsp1 cells were rescued by

232 their role in ciliogenesis, we investigated mutant phenotypes of zebrafish crumbs genes.

233 al classes of genes have been associated, by mutant phenotypes or cell biology, with the formation of

234 genic lines, gene expression, gene function, mutant phenotypes, orthology, human disease models, nome

235 cription factors partially rescues vih1 vih2 mutant phenotypes, placing diphosphoinositol pentakispho

236 ermore, transcription patterns together with mutant phenotypes pointed to the involvement of GLV4 and

237 zed by analyzing expression patterns, double mutant phenotypes, promoter-GUS fusions and expression o

238 Mutant phenotypes provide strong clues to the functions

239 d-type gene product, however, can also cause mutant phenotypes, providing geneticists with an alterna

240 sted repressive role is a result of specific mutant phenotypes, rather than a reflection of the norma

241 owever, despite extensive study, the SV40 HR mutant phenotype remains poorly understood.

242 dentifying the genetic changes that underlie mutant phenotypes remains a significant bottleneck in th

243 We establish that the mutant phenotype represents a gain of function and can b

244 Hinge mutant phenotypes resemble loss of Pds5p, which binds op

245 The trr mutant phenotype resembles that of Utx, which encodes a

246 Analysis of CSN1b mutant phenotypes revealed a requirement for the COP9 si

247 te how our system confirms causality through mutant phenotype reversion.

248 Genetic analysis indicated that the mutant phenotype segregates as a single recessive Mendel

249 in a subdomain of the shoot apical meristem, mutant phenotype showing defect in polar leaf and/or mer

250 Here, we observe mutant phenotype similarities between another subunit, M

251 mponent system ChvG-ChvI, and the suppressor mutant phenotypes suggest that all or most of the charac

252 era of human Hook3 and Hok1 rescues the hok1 mutant phenotype, suggesting functional conservation bet

253 e raptor knockdown did not phenocopy the TSC mutant phenotype, suggesting that a novel role exists fo

254 factors and RNAi genes failed to revert the mutant phenotype, suggesting the involvement of a distin

255 e find that human Leptin can rescue the upd2 mutant phenotypes, suggesting that Upd2 is the functiona

256 Genetic analysis of mutant phenotypes suggests that RecG is needed to dissip

257 e 14-kb eps cluster resulted in an acapsular mutant phenotype that was not able to produce either EPS

258 of individual miRNAs often induces specific mutant phenotypes that can guide their functional study.

259 pmental roles to them is hampered by complex mutant phenotypes that often emerge after gastrulation(3

260 gpa1-null mutant background revealed various mutant phenotypes that were complemented by either AtGPA

261 with a causal role for elevated IS in dfmr1 mutant phenotypes, the expression of dfmr1 specifically

262 ominantly responsible for the observed yjbIH mutant phenotypes, though a minor role exists for the pu

263 GA signaling is sufficient to suppress arf2 mutant phenotypes through repression of GNC and GNL.

264 encoding gene, bba66, and characterizing the mutant phenotype throughout the natural mouse-tick-mouse

265 cient met7 yeast is able to rescue the yeast mutant phenotype, thus demonstrating that bm4 encodes a

266 Expressing OsRZFP34 in atrzfp34 reverted the mutant phenotype to normal, which indicates a conserved

267 miR165-mediated cleavage reversed the stp-2d mutant phenotype to wild-type, indicating that AtHB15 re

268 egrated S-linked genes, marker sequences and mutant phenotypes to create a map of the P. vulgaris S l

269 We used these expression patterns and mutant phenotypes to develop a margin-patterning model t

270 two groups of transcripts connected to dek1 mutant phenotypes: transcripts related to cell wall remo

271 ype cells and highlights the need to examine mutant phenotypes under a range of conditions.

272 LR9 knock-out (KO) mice resemble the UNC93B1 mutant phenotype upon infection with L. major.

273 The OpBR mutant phenotype variably includes bone expansion and fu

274 al area of control mice, and a rescue of the mutant phenotype via pharmacological potentiation of AMP

275 sequencing revealed that, in both cases, the mutant phenotype was associated with mutations in the CY

276 The mutant phenotype was characterized using cell and molecu

277 The mutant phenotype was completely rescued by transgenic ex

278 The PBC mutant phenotype was evaluated in assays using monolayer

279 The gene responsible for the mutant phenotype was found to encode a putative protein

280 The mutant phenotype was partially rescued by retinoic acid

281 The deletion mutant phenotype was reproduced by using transformants w

282 h screening for chemical suppressors of sspo mutant phenotypes, we also identify potent agents capabl

283 y of Vps35 variants to rescue multiple vps35-mutant phenotypes, we found that the D620N mutation conf

284 Gsx overexpression contributes to the Dlx1/2 mutant phenotypes, we made compound loss-of-function mut

285 The xyl1 mutant phenotypes were associated with modifications to

286 d complementation tests showed that the lls1 mutant phenotypes were caused by the Tnt1 insertions tha

287 The tyra2 mutant phenotypes were exacerbated by TyrA1 suppression

288 Among the genes with robust mutant phenotypes were gdpP, which encodes a phosphodies

289 Two distinct mutant phenotypes were observed: an excess of buds on th

290 Remarkably, most of these mutant phenotypes were rescued by supplying sucrose to t

291 -GFP was broadly expressed in seedlings, but mutant phenotypes were restricted to root hairs, indicat

292 scherichia coli failed to complement the upp mutant phenotype when targeted to the chloroplast, sugge

293 ly, knockdown of Sox6 fully rescued the Trbp-mutant phenotype, whereas mice overexpressing Sox6 pheno

294 dentified OsCADT1 as the causal gene for the mutant phenotype, which encodes a putative serine hydrox

295 data could be used to predict site-directed mutant phenotypes, which may broaden the classic antirec

296 s were selected for further analysis through mutant phenotyping, which revealed combinations of trans

297 TAN1-DeltaI-YFP, failed to rescue the double mutant phenotype, while TAN1 missing a conserved middle

298 Functional complementation of the mutant phenotype with the addition of tryptophan suggest

299 ning procedure predicted known knockdown and mutant phenotypes with high precision.

300 e limbs, hyperphalangy in cetacean flippers, mutant phenotypes with misoriented joints and suggests a