ライフサイエンスコーパス: mutate

1 lly affect tissues depending on which ARS is mutated.

2 motif required for chlorophyll binding were mutated.

3 er (TNBC), a subtype in which p53 is usually mutated.

4 hyper-methylated tumors, 6 (10.7%) were IDH1 mutated.

5 rone to impact transcriptional regulation if mutated.

6 f regulatory activity, and by systematically mutating 245 HOT loci with a massively parallel mutagene

7 a mouse model by using CRISPR technology to mutate a single internal translation initiation site in

8 n alter transcription factor (TF) binding by mutating a TF binding motif, which in turn may affect th

9 ould be used for targeting HCCs that express mutated/activated beta-catenin variants that are current

10 ceptibility to CKD in rats with wild-type or mutated Add3 and in genetically modified rats with overe

11 We mutated all seven Physcomitrium (Physcomitrella) patens

12 Mutating all motifs blocks it, as does transforming them

13 Two mutants with all Ppal15kDa copies mutated almost completely lost pathogenicity.

14 Using TP53-mutated AML cell line THP1 and patient-derived AML cells

15 genes' expression to the development of NPM1-mutated AML is also highlighted.

16 ations have been recurrently detected in IDH-mutated AML samples.

17 ological and clinical issues related to NPM1-mutated AML.

18 in, we established a xenograft model of TP53-mutated AML.

19 thways in these patients with RUNX1 germline-mutated AML.

20 induction and consolidation therapy in NPM1-mutated AML.

21 es during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii).

22 ant difference observed between samples with mutated and intact 1C cycle proteins.

23 asia mutated (ATM) and ataxia telangiectasia mutated and RAD3-related (ATR) at Ser101 and Ser241 to a

24 with Ku70/Ku80 and the ataxia telangiectasia mutated and RAD3-related (ATR) at the protein level, res

25 mismatch repair protein-encoding genes were mutated at lower frequency (6%, 18%) with significant co

26 t, complementation with NCgl2764 derivatives mutated at residues essential for methyltransferase acti

27 ugh phosphorylation by ataxia telangiectasia mutated (ATM) and ataxia telangiectasia mutated and RAD3

28 late autophagy through ataxia-telangiectasia mutated (ATM) and cell cycle checkpoint kinase 2 (CHK2),

29 ve recently shown that ataxia-telangiectasia-mutated (ATM) deficiency in CD4 T cells accelerates DNA

30 Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to devel

31 Phosphorylation of ataxia-telangiectasia mutated (ATM) is the initial step in the DNA damage resp

32 on wild type cells and ataxia telangiectasia mutated (ATM) patient cells.

33 The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its fun

34 nuclear expression of Ataxia Telangiectasia Mutated (ATM) protein within melanocytes in anagen hair

35 rylated at Ser(384) by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphor

36 reduced expression of ataxia-telangiectasia mutated (ATM), and exhibited multiple mitotic defects.

37 subclone SCAP-O(BCOR-mut) expressed only the mutated BCOR transcripts and remained in such condition

38 d be classified in the following rank order: mutated BEAT > original BEAT > knobs-into-holes.

39 inding experiments, comparing original BEAT, mutated BEAT, and "knobs-into-holes" interfaces, suggest

40 July 18, 2018, 43 patients with BRAF(V600E)-mutated biliary tract cancer were enrolled to the study

41 ination therapy in patients with BRAF(V600E)-mutated biliary tract cancer.

42 Mutating both half GR binding sites did not significantl

43 Loss of APE2 is lethal in cells with mutated BRCA1 or BRCA2, making APE2 a prime target for h

44 ts provide reassurance to patients with BRCA-mutated breast cancer interested in future fertility.

45 BRCA1 or BRCA2-mutated breast cancers are sensitive to poly(ADP-ribose)

46 that aDNA molecules are short and frequently mutated by post-mortem chemical modifications.

47 ont) infection induced the conversion of the mutated C1 into a PK-resistant and infectious form perpe

48 While many frequently-mutated cancer driver genes have already been identified

49 resent a more accurate representation of the mutated cancer genomes.

50 xploration of the genomic landscape of LRRK2-mutated carcinomas yielded frequent TP53 deactivation an

51 reclassify tumors by moving BRAF and/or NRAS mutated cases to MSF.

52 By mutating catalytic residues of two such enzymes, we engi

53 s derived from formalin-fixed tumors, a POLE mutated cell line and standard DNA by WES and five diffe

54 ted to activate the proliferation of dormant mutated cells, thus generating actively growing lesions,

55 antigens (TAAs) comprise a large set of non-mutated cellular antigens recognized by T cells in human

56 was used to compare wild-type channels with mutated channels.

57 o discuss the importance of eradicating NPM1-mutated clones to achieve AML cure and the impact of pre

58 ffects on the overall disease burden of JAK2-mutated clones(6,7), prompting us to investigate the mec

59 at amplification of ERK1/2 signaling in KRAS-mutated colorectal cancer cells affects the cytokine mil

60 identify amplified ERK1/2 signaling in KRAS-mutated colorectal cancer cells as a driver of tumor-str

61 er Genome Atlas Database indicates that KRAS mutated colorectal cancer patients with low intratumor f

62 ble interest in identifying genes that, when mutated, confer risk that is largely specific for autism

63 hylorubrum extorquens AM1 PqqE to a range of mutated constructs.

64 : 1.30, 1.89; Pheterogeneity <= 0.001), BRAF-mutated CRC (OR per 5 kg/m2: 1.56; 95% CI: 1.22, 1.99; P

65 o identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact of oncogenic KRA

66 was demonstrated with libraries of randomly mutated cytochrome P411 variants to identify improved ca

67 ppressor gene and one of the most frequently mutated/deleted genes in human prostate cancer (PCa).

68 like most tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor p

69 ntal and neurodegenerative pathology in PNKP-mutated disease, and the extent and nature of this reduc

70 t progress along a common pathway with BRCA1-mutated disease, representing a promising DNA-based biom

71 in cigarette smoke that directly damage and mutate DNA(4,5).

72 lthy donors, and full discrimination between mutated DNA from patients over wild-type DNA from health

73 eferentially stimulates ATPase activity, and mutating Dnmt5's ATP-binding pocket disproportionately r

74 oma using multiplatform analysis of commonly mutated driver and nonpassenger genes.

75 effects (fitness landscape) within commonly mutated driver genes.

76 Arabidopsis thaliana; AtLAZY1) was tested by mutating each region and measuring how well transgenic e

77 Here we report that the inhibition of mutated EGFR promotes the secretion of a potent vasocons

78 all cell lung cancer (NSCLC) population with mutated EGFR receiving TKIs and CRT.

79 Ectopic overexpression of EDN1 in cells with mutated EGFR resulted in poor drug delivery and retarded

80 and supported the growth of tumors driven by mutated EGFR.

81 e database comprises 2 539 031 non-redundant mutated entries from 17 599 proteins, of which 2 377 103

82 tumor immune activity was increased in EP300 mutated esophageal, stomach and prostate cancers.

83 hree percent of patients (32/51; 62.7%) were mutated for at least one of the genes tested and TP53 wa

84 ms fibrils both under cellular stress and in mutated form in neurodegenerative conditions.

85 e MIE promoters during HCMV reactivation, as mutating FOXO binding sites in alternative MIE promoters

86 TP53 is the most frequently mutated gene in cancer, yet these mutations remain thera

87 transferase 3A (DNMT3A) is the most commonly mutated gene in clonal hematopoiesis (CH).

88 repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson's disease(1) and is a

89 echanisms by which TP53, the most frequently mutated gene in human cancer, suppresses tumorigenesis r

90 The TP53 gene is the most frequently mutated gene in human cancers, and the majority of TP53

91 nd this may be why TP53 is the most commonly mutated gene in human cancers.

92 gth human PRSS1R122H gene, the most commonly mutated gene in human HP, into mice.

93 KRAS is the most commonly mutated gene in pancreatic cancer, but clinical agents t

94 %), TP53 (26%) and SOX8 (19%), a recurrently-mutated gene previously unreported in EnOC.

95 FLT3 is a frequently mutated gene that is highly associated with a poor progn

96 enes tested and TP53 was the most frequently mutated gene.

97 The significantly mutated genes (q <= 0.01) were PIK3CA (28% of patients),

98 Distribution of recurrently mutated genes and clonal architecture differed among MDS

99 ategy for complex diseases with a variety of mutated genes and heterogeneous phenotypic manifestation

100 t also other factors such as the function of mutated genes and residual activities of mutant alleles.

101 The distinct sets of mutated genes derived here show substantial prognostic p

102 Analysis of seven commonly mutated genes from 178 studies in cBioPortal revealed th

103 PIK3CA is one of the two most frequently mutated genes in breast cancers, occurring in 30-40% of

104 IT and/or NRAS mutation, known as frequently mutated genes in GCTs, in 3/12 (25%) patients.

105 ing studies have identified many recurrently mutated genes in human SCLC tumors.

106 Differences in the frequency of mutated genes in MDS and secondary AML indicate that the

107 The mutated genes involved in cavefish vestigial eye formati

108 the transsulfuration pathway, as one of the mutated genes responsible for eye degeneration in multip

109 cing (WES) of 47 tumors revealed recurrently mutated genes that included KDR, TP53, and PIK3CA.

110 ong the overall 801 HCC, the most frequently mutated genes were telomerase reverse transcriptase (TER

111 stic fibrosis (CF), require inheritance of 2 mutated genes.

112 rculating tumor DNA (ctDNA) in CSF to detect mutated genes.

113 Starch properties can be modified by mutating genes responsible for the synthesis of amylose

114 ith tandem duplication events found in BRCA1-mutated genomes.

115 Chemogenomic analysis of mutated glioma genes reveals potential drug targets, wit

116 Results Three participants with IDH1-mutated gliomas (mean age, 50 years +/- 21 [standard dev

117 Such a mutated HC/B gains the ability to bind receptor-free lip

118 sistance is present in individuals with NRF2-mutated HCC and if this resistance can be overcome by me

119 However, mutating hmx2 in hypomorphic hmx3a mutants that usually

120 r skews in transcriptional priming of DNMT3A-mutated human clonal hematopoiesis bone marrow progenito

121 ng is possible in isocitrate dehydrogenase 1-mutated human glioma by using a super-resolution framewo

122 NIH/3T3 cells transfected with wild-type and mutated human L1 genes.

123 , we first inferred SigMaps for the ten most mutated human oncoproteins and then for the full reperto

124 S-activation is an obligatory consequence of mutated/hyperphosphorylated JAK2.

125 -120)-a small-molecule targeted inhibitor of mutated IDH1-in patients with previously treated IDH1-mu

126 Enasidenib, an inhibitor of mutated IDH2 proteins, induces responses in patients wit

127 onoclonal antibodies recognizing IGLV3-21 or mutated IGLV3-21(R110) facilitates the recognition of B

128 Nfkbia(NES/NES) CD8 T cells harboring a mutated IkappaBalpha nuclear export sequence abnormally

129 al study showed TP53, NOTCH1 and DNMT3 to be mutated in 84.6%, 69.2% and 30.0% of sensitive cell line

130 BAP1 is mutated in a broad spectrum of tumors.

131 tical regulator of ciliogenesis, and is also mutated in a hereditary neurodegenerative disorder, spin

132 ophosmin is commonly both over-expressed and mutated in acute myeloid leukemia (AML).

133 ns 1-10 (and so lacks the region of sequence mutated in AML).

134 ey developmental E3 ubiquitin ligase that is mutated in an intellectual disability syndrome.

135 higher mutational burden in genes frequently mutated in ATL than did high-risk, age-matched HTLV-1 ca

136 Genes that are mutated in Autism Spectrum Disorders (ASD) can be classi

137 ion sequencing has identified the genes most mutated in bladder cancer.

138 oma are usually distinct, but DDX3X is often mutated in both subgroups.

139 ations in NF1 or KMT2D, which are frequently mutated in breast cancer.

140 pend on dNTPs to replicate and is frequently mutated in cancers and Aicardi-Goutieres syndrome, a her

141 ne kinases (RTKs) are often overexpressed or mutated in cancers and drive tumor growth and metastasis

142 KDM6A is frequently mutated in cancers and functions as a tumor suppressor.

143 PRKN was the gene most frequently mutated in Caucasians, whereas PINK1 mutations predomina

144 roximately 20 genes are recurrently found as mutated in CH, indicating they confer some advantage.

145 nd RAB-like small GTPase 1), whose genes are mutated in ciliopathies.

146 enomatous polyposis coli (APC) is frequently mutated in colorectal cancers.

147 and TGFBR2 as additional genes significantly mutated in CRC.

148 These proteins are mutated in Fanconi anaemia, a disease in which patients

149 Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk fa

150 tion in one of eleven other genes frequently mutated in HCC.

151 nuclear transport and stability and that is mutated in human advanced sleep phase syndrome.

152 catalytic subunit of PI3K and is frequently mutated in human cancers, including ~30% of colorectal c

153 Here, we report that HACE1 is frequently mutated in human lung cancer.

154 tion partner for MYC family proteins that is mutated in human SCLC.

155 entral component of the Ras/MAPK cascade, is mutated in human tumors and developmental disorders.

156 hotoreceptor-specific gene C2orf71, which is mutated in inherited retinal dystrophy (RP54).

157 SRPK family genes are also mutated in intellectual disability disorders, and patien

158 ecent studies on TBL1XR1, a gene recurrently mutated in MCD/C5s and PENLs, suggest that aberrant memo

159 isome-associated E3 ubiquitin ligase that is mutated in microcephalic primordial dwarfism.

160 ank3, and L-type calcium channels, are often mutated in multiple neuropsychiatric disorders.

161 ner of TCF12, and stub1, a gene that is both mutated in other syndromic forms of IGD and maps to a TC

162 static recurrence that are not significantly mutated in primary cancers, implicate membrane progester

163 ts inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts

164 -regulatory elements within the FOXA1 plexus mutated in primary prostate tumors as potential targets

165 t non-coding AR binding sites are frequently mutated in prostate cancer and can impact enhancer activ

166 alize 65 new candidate loci, including genes mutated in rare hematological syndromes (ADA, GP6, IL17R

167 of the MAPK cascade joins the group of genes mutated in RASopathies.

168 OBP, KCNJ12, and KMT2C, which are frequently mutated in skin cancers, indicating their potential role

169 drugging gene products that are recurrently mutated in specific cancer types.

170 9 genes were significantly differentially mutated in the 3 TIME types with strongest differences f

171 EGFR, down-regulating FUS, or expressing FUS mutated in the EGFR-targeted phosphorylation sites.

172 ire action potentials - notably ion channels mutated in the epilepsies - yet data now support a surpr

173 y both strains, and nodules formed on plants mutated in the stearoyl-acyl carrier protein desaturase

174 Given that NIP30 is frequently mutated in the TCGA cancer database, our results provide

175 ox Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless (WNT) and Sonic hedghog (SHH) su

176 non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring n

177 iciency of oncogenes that are preferentially mutated in tumor samples is increased in proliferative c

178 ne families some members are more frequently mutated in tumor samples than their family counterparts.

179 radation controlled by ataxia telangiectasia mutated-induced phosphorylation at Ser(384) constitutes

180 propose that Cnr is an unstable gene that is mutated insertionally at high frequency, most commonly d

181 feration in Adenomatous polyposis coli (APC)-mutated intestine.

182 489, 500, 501, and 505, have high chances to mutate into significantly more infectious COVID-19 strai

183 have spread outside East Asia without first mutating into derived B types, pointing to founder effec

184 We mutated K4 or K36 to alanine in the histone variant H3.3

185 We mutated KMT2D in neural crest cells (NCCs) to study cell

186 a in mouse models of MLL1-rearranged or NPM1-mutated leukemia, including patient-derived xenograft mo

187 EGFR-mutated lung adenocarcinoma patients treated with gefiti

188 In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced eff

189 Rediversification of mutated MBCs is infrequent within secondary germinal cen

190 thesis genes are transcriptionally silent or mutated, meaning that cholesterol uptake from lipoprotei

191 d mathematical flux balance analyses in BRAF-mutated melanoma cells to discover that elevated antioxi

192 sites, followed by GC producing somatically mutated memory B cells (MBC) and long-lived plasma cells

193 One hundred six patients with BRAF(V600E)-mutated metastatic CRC previously treated with one or tw

194 DLC1 was the Rho-GAP gene mutated most frequently, with 5%-8% of tumors in five of

195 In Mks from patients with CALR-mutated MPNs, defective interactions between mutant calr

196 , it was reflected in the relative impact of mutating msa as assessed in a murine osteomyelitis model

197 netrin-1 in the skin cells of a BRAF(V600E)-mutated murine model reduced cancer cell death and promo

198 ng chromosome 6q are common in patients with mutated MYD88 and include genes that modulate NFKB, BCL2

199 is a subgroup analysis of patients with IDH2-mutated myelodysplastic syndromes in the phase 1 dose-es

200 lthy individuals and from patients with CALR-mutated myeloproliferative neoplasms (MPNs).

201 risingly, we also report that simultaneously mutating N65 and N82 causes early termination of alpha(1

202 To test this hypothesis in vivo, we mutated Nae1, an obligative subunit of the E1 for neddyl

203 could be exploited for the treatment of KRAS-mutated neoplasms.

204 ression in acute myeloid leukemia (AML) with mutated NPM1 provides a rationale for the evaluation of

205 was required for 3D spheroid growth of EGFR-mutated NSCLC cells.

206 t+Flt3+ cell frequency in blood and its BRAF-mutated offspring reported response to chemotherapy.

207 se the voltage dependence of HCN channels by mutating only two residues located at the interface betw

208 In RGCs expressing mutated Opa1, active 5' AMP-activated protein kinase (AM

209 The mutated OPG is incapable of binding to HS but binds RANK

210 Several pathways were preferentially mutated or altered in metastases, including mTOR, CDK/RB

211 Korea) with germline BRCA1-mutated or BRCA2-mutated or both and histologically confirmed, progressiv

212 or older in South Korea) with germline BRCA1-mutated or BRCA2-mutated or both and histologically conf

213 o identify genes and pathways preferentially mutated or copy-number altered in metastases compared wi

214 ke chromatin remodeller family member and is mutated or misregulated in several cancers and some case

215 HEK293T cells were monitored in response to mutated or truncated forms of transfected Man1b1.

216 10 and p53 survive longer than do those with mutated p53 or less RBM10.

217 Mice carrying a mutated p85alpha that cannot be cleaved by LF show a gre

218 g Administration, olaparib for germline BRCA-mutated pancreatic ductal adenocarcinoma is expected to

219 Here, we show that ARH3-mutated patient cells accumulate mono(ADP-ribose) scars

220 One-third of TP53-mutated patients had monoallelic mutations whereas two-t

221 The mutated PDE3A gene drives mechanisms that increase perip

222 )' database is a compilation of Homo sapiens mutated peptides in FASTA format, that was constructed f

223 In this study, we found that mutating Phe(20) to cyclohexylalanine (Cha) in macrocycl

224 d breaks by activating Ataxia Telangiectasia Mutated, phosphorylating histone H2AX, and localizing RA

225 itional knockout (cKO) mouse to specifically mutate Plk1 in oocytes.

226 d in TMEM30A-knockout cell lines and TMEM30A-mutated primary cells, explaining the improved treatment

227 y detectable, likely due to low frequency of mutated progenitors.

228 ated that cohesin is among the most commonly mutated protein complexes in cancer.

229 e lysine cluster blocks PIP(2) binding, this mutated protein domain retains the ability to bind physi

230 n of the genome", p53 is the most frequently mutated protein in cancer and almost all cancers exhibit

231 surface markers are usually overexpressed or mutated protein receptors for which spatiotemporal regul

232 nteracts with several developmental disorder-mutated proteins including WDR5, a core component of H3K

233 ype could be explained by the ability of the mutated proteins to physically interact with and sequest

234 R) basket trial in patients with BRAF(V600E)-mutated rare cancers.

235 Mutating region V severely disrupted function without af

236 These frequently mutated regulatory elements (FMREs) were ubiquitously ac

237 ins, induces responses in patients with IDH2-mutated, relapsed or refractory acute myeloid leukaemia.

238 mical and crystallographic data show how the mutated residues modulate the binding and activation of

239 o an upper bound on the distance between the mutated residues.

240 Remarkably, ES7L-mutated ribosomes showed increased segregation into cyto

241 c interaction motif domain of RIPK1 has been mutated (Ripk1 (mRHIM/mRHIM)).

242 on constant (K(D) ) of ~700 pm Analyses with mutated RNA constructs, and the application of in vitro

243 referably interacted with phosphomimetically mutated RORalpha at Ser100 residue in co-IP assay.

244 Here, we mutated RSPO (RSPO2 F105R/F109A) to eliminate LGR bindin

245 serving ZNRF3/RNF43 binding and targeted the mutated RSPO to a liver specific receptor, ASGR1.

246 Mutating Ser162 to Alanine produces constitutive activit

247 iated with PAX8 comprise the most frequently mutated set of enhancers in OC (P = 0.003).

248 Here, we have mutated several hydrophobic residues from I360 to F370 i

249 SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants cor

250 etection, with the potential to discriminate mutated strands, is of paramount importance.

251 Mutating subsets of both motifs partially alleviates non

252 a number of perturbed interactions with the mutated tail.

253 In addition, mutating Tat renders M28 bacteria more sensitive to oxid

254 an effect that was inhibited by blocking or mutating the adhesin RadD on Fusobacterium and removal o

255 By contrast, inhibiting the ISR by mutating the eIF2alpha phosphorylation site, genetically

256 Mutating the miR-9-3p or miR-9-5p MREs prevented this de

257 Nonetheless, mutating the morpholino binding sites in both maternal a

258 Here we investigated the effects of mutating the OsSBEIIb gene encoding starch branching enz

259 Unexpectedly, mutating the PEP surface and the hydrophobic interface o

260 aminase that can restrict HIV-1 infection by mutating the viral genome.

261 n these amino acid residues are individually mutated, the necrosis-inducing activity is completely ab

262 ) are sites at which B cells proliferate and mutate their antibody-encoding genes in the dark zone (D

263 sed on previous X-ray crystal structures, we mutated three conserved residues in the Nef dimer interf

264 hogenic avian influenza viruses (LPAIVs) can mutate to highly pathogenic forms and are therefore subj

265 The NLS residues were mutated to alanine using a type A full-genome cDNA clone

266 erine sites Ser722 and Ser792 of RAPTOR were mutated to alanine.

267 rylation sites on serines 63, 68, and 69 are mutated to alanines), in which phospholemman is rendered

268 sing Msh3 in which these lysine residues are mutated to arginine, the inhibitory effect of RGFP966 on

269 e multiple reactive cysteines, which must be mutated to other residues to enable labeling of unique p

270 m calponin homology domains (CH1-CH2) can be mutated to preferentially bind actin networks at the fro

271 rat Amyloid Precursor Protein (App) gene was mutated to produce human Abeta.

272 out half when either of the two H2A genes is mutated to the nonphosphorylatable S129A allele.

273 median follow-up of 28 months, del(17p) and mutated TP53 were the only abnormalities with an effect

274 fts of a drug-resistant NB line SK-N-BE(2)C (mutated TP53); (iii) flank xenografts of a drug-resistan

275 s lower in patients with del(17p), del(11q), mutated TP53, ATM, and BIRC3, none of these parameters r

276 fied del(17p), del(11q), unmutated IGHV, and mutated TP53, BIRC3, and SF3B1 as independent prognostic

277 ssion and maintenance of AML, a bias towards mutated transcripts could have a significant impact on d

278 was highly degenerate and appeared to have a mutated transposase and terminal sequences, while a seco

279 Phenotype and function of FOXP3-mutated Treg cells from rapamycin-treated patients with

280 Wild-type (WT) and mutated TrkB knock-in mice (Ntrk2tm1Ddg/J) with impaired

281 PTEN is a frequently mutated tumor suppressor that has been linked to the PTE

282 pursued as a potential therapy to treat EGFR-mutated tumors.

283 y in the clinical management of several BRCA-mutated tumors.

284 ie their clinical activities in various BRCA-mutated tumors.

285 icopathologic features associated with LRRK2-mutated tumors.

286 and CDKN2B, validating observations in FMRE-mutated tumors.

287 ation of Smo by an E1 ligase inhibitor or by mutating two lysine residues in intracellular loop three

288 effect of DAGK inhibition was eliminated by mutating two PKC-targeted phosphorylation sites, Ser-502

289 were aged 18 years or older, had BRAF(V600E)-mutated, unresectable, metastatic, locally advanced, or

290 ficient cancer cells as well as Galpha(q/11) mutated uveal melanoma.

291 37 cell lines stably expressing WT SAMHD1 or mutated variants defective in dNTPase activity (HD/RN) o

292 alent inhibitors against the most frequently mutated version of RAS in non-small-cell lung cancer, KR

293 truction of B7H3 CAR T cells incorporating a mutated version of the HSV1-tk gene (sr39tk) with improv

294 HIF-1alpha target genes are enriched in TP53-mutated versus TP53-wild-type AML.

295 enzyme catalytic subunit 3) proteins, which mutate viral nucleic acids.

296 Chromatin remodeling genes were frequently mutated, whereas mutations were absent in several major

297 Controls where lysines were mutated with charged residues accessed similar morpholog

298 All spontaneously regressed tumors were IGHV-mutated with no restricted IGHV usage or B-cell receptor

299 Regions III and IV could be mutated without large impact on function or localization

300 otypic features of tumor cells from 35 MYD88-mutated WM patients in relation to normal plasma and B-c