ライフサイエンスコーパス: mutation accumulation

1 with purely deleterious late-life effects ("mutation accumulation").

2 neutral (or nearly neutral) mutations (i.e., mutation accumulation).

3 nvironments, and thus the tradeoff is due to mutation accumulation.

4 gated ER Ca2+ replenishment may be linked to mutation accumulation.

5 degrade over time as a result of spontaneous mutation accumulation.

6 an average of 370 generations of spontaneous mutation accumulation.

7 he Sia-recognition domain, suggesting biased mutation accumulation.

8 strongly supported by forward simulations of mutation accumulation.

9 trols was assayed after 27-33 generations of mutation accumulation.

10 or dissecting factors that jointly influence mutation accumulation.

11 ry diversity and SARS-CoV-2's slower pace of mutation accumulation.

12 and curtails the capacity of LGT to prevent mutation accumulation.

13 oss of guanine content consistent with mtDNA mutation accumulation.

14 menarche in women is associated with delayed mutation accumulation.

15 additional nonindependent and faster mode of mutation accumulation.

16 tion doublings permitted analysis of nascent mutation accumulation.

17 cell death as an important defense to avoid mutation accumulation.

18 ce of meiosis and sex is expected to lead to mutation accumulation.

19 the parameter space in which models predict mutation accumulation.

20 Ageing may be due to mutation accumulation across the lifespan, leading to ti

21 We found that the rate of mutation accumulation after puberty is similar between m

22 d demographic models to represent effects of mutation accumulation and antagonistic pleiotropy on ran

23 jor theories of the evolution of senescence (mutation accumulation and antagonistic pleiotropy) make

24 cesses can produce ecological specialization-mutation accumulation and antagonistic pleiotropy.

25 hermore, the trajectory showed clear evident mutation accumulation and clonal expansion along with th

26 lease deficiency shed light on mechanisms of mutation accumulation and considerations for immunothera

27 de mutation load, exacerbates the effects of mutation accumulation and cumulatively contribute to the

28 ression by individual pollen grains can slow mutation accumulation and degeneration of the Y chromoso

29 rrent mutation, population structure, and/or mutation accumulation and drift.

30 ttle is known about the relationship between mutation accumulation and gene reassortment for rotaviru

31 icula to mitigate the effects of deleterious mutation accumulation and increase potentially adaptive

32 ng that most metabolic erosion was driven by mutation accumulation and not by physiological tradeoffs

33 ded hosts are necessary to cope with natural mutation accumulation and pervasive lateral gene flow.

34 DNA repair pathways in preventing C. elegans mutation accumulation and provides evidence for the pres

35 xual diploid species is not only a matter of mutation accumulation and reduced efficiency of selectio

36 is based upon a population dynamics model of mutation accumulation and selection in colorectal tissue

37 This leads to mutation accumulation and somatic cell mosaicism in mult

38 mote repair or apoptosis, thereby preventing mutation accumulation and suppressing tumor development.

39 To provide insights into mutation accumulation and transmission in plants, we pro

40 gene-drug interactions and extend the use of mutation accumulation and whole-genome sequencing analys

41 Two recent reports combine mutation accumulation and whole-genome sequencing to mea

42 ed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neu

43 ing to its rapid proliferation, high rate of mutation accumulation, and genetic tractability.

44 linked genes is an accidental by-product of mutation accumulation, and not driven by selection to ei

45 general evolutionary theory, along with the mutation accumulation, antagonistic pleiotropy, and disp

46 Drosophila melanogaster by using a modified mutation accumulation approach.

47 Alternatives to the mutation-accumulation approach have been developed to ch

48 on rate, 7.1 x 10(-7) The curve of subclonal mutation accumulation as a function of sequencing depth,

49 or mortality in Drosophila, and they support mutation accumulation as a viable mechanism for the evol

50 teaus, with both antagonistic pleiotropy and mutation accumulation as driving population genetic mech

51 Last, both mutation accumulation assays and high-depth whole-exome

52 Mutation accumulation assays reveal a ~5-8 fold elevatio

53 s predictions for senescent mortality due to mutation accumulation, at the price of reliance on a lin

54 portunity for recombination to slow down the mutation accumulation, but always at a cost of increased

55 The polyploid state reduces spontaneous mutation accumulation by gene conversion, the freshly mu

56 on-Ig loci, many of which are protected from mutation accumulation by high-fidelity DNA repair.

57 inally, we show that the rates of endogenous mutation accumulation by intrinsic processes are not suf

58 eory suggests that the risk of extinction by mutation accumulation can be comparable to that by envir

59 We correlate clade growth with mutation accumulation, compare rates of nonsynonymous to

60 on, yet the germline is highly refractory to mutation accumulation compared with somatic cells.

61 arent decline in viability under spontaneous mutation accumulation could have been nonmutational, per

62 Subsequent workers have suggested that mutation accumulation could produce an age-related incre

63 Employing mutation accumulation data for E. coli we show that the

64 spite the increasing availability of QTL and mutation accumulation data, such data have not yet been

65 ate of viral suppression and drug-resistance-mutation accumulation derived from patients receiving pr

66 Mutation accumulation diminishes the degree of adaptatio

67 once fitness reached a maximum, the rate of mutation accumulation dropped.

68 -old than in 1-month-old mice, demonstrating mutation accumulation during the period of only 9 mo.

69 ate them is essential in preventing unwanted mutation accumulation during their in vitro cultivation.

70 ve trait and have implications regarding the mutation-accumulation evolutionary explanation of senesc

71 "treatment" alleles on one chromosome during mutation accumulation experience an elevated mutation ra

72 liver gene expression in individuals from a mutation accumulation experiment (MA) with the C3H inbre

73 sets, including from the largest Arabidopsis mutation accumulation experiment conducted to date, we d

74 We conducted a mutation accumulation experiment for approximately 350 g

75 Here, we report the results of a mutation accumulation experiment performed on panmictic

76 estructive cheaters to spread, as shown by a mutation accumulation experiment.

77 Here we present the results of a mutation-accumulation experiment designed to assess the

78 We sequenced eight genomes produced by a mutation-accumulation experiment in Drosophila melanogas

79 We performed a mutation-accumulation experiment in E. coli and show tha

80 We have performed a mutation-accumulation experiment similar to those of Muk

81 s estimated as 2 x 10(-4) in a 10-generation mutation-accumulation experiment.

82 his purpose using (1) de novo mutations from mutation accumulation experiments and (2) extremely rare

83 Recently, the coupling of mutation accumulation experiments and next-generation se

84 Mutation accumulation experiments have shown that hyperm

85 tness, but most information comes from a few mutation accumulation experiments in Drosophila in which

86 e germline and somatic genome.(9) Performing mutation accumulation experiments in the model ciliate T

87 e model is based on mutation parameters from mutation accumulation experiments involving balancer chr

88 To address these gaps, we performed mutation accumulation experiments using clonal populatio

89 Mutation accumulation experiments were performed by sequ

90 of high mutation rates with weak selection (mutation accumulation experiments) and low mutation rate

91 Using genome-wide genetic screens and mutation accumulation experiments, we uncover the cellul

92 the distribution of mutational effects from mutation accumulation experiments.

93 Mutation-accumulation experiments are widely used to est

94 Mutation-accumulation experiments have been used to stud

95 crepancy between the present s and that from mutation-accumulation experiments in Drosophila (approxi

96 fects of deleterious mutations by performing mutation-accumulation experiments on five viral genotype

97 measure such rates and patterns directly in mutation-accumulation experiments or tries to infer them

98 We confirmed our hypothesis in mutation-accumulation experiments that showed a normaliz

99 Mutation-accumulation experiments, in which mutations ar

100 Genomic data from mutation-accumulation experiments, parent-offspring trio

101 s that are consistent with observations from mutation-accumulation experiments.

102 intensive, relying on long-term, laboratory mutation-accumulation experiments.

103 enic aquatic microcrustacean, using parallel mutation-accumulation experiments.

104 iews the three strands and, concentrating on mutation accumulation, extends a mathematical result wit

105 Using mutation accumulation followed by whole-genome sequencin

106 istic pleiotropy appears more important than mutation accumulation for the decay of unused catabolic

107 (CPMs) can be used to infer dependencies in mutation accumulation from cross-sectional data and prov

108 Somatic mutation accumulation has been implicated as a major cau

109 rom the same patient, it helps to reveal the mutation accumulation history, track cancer progression,

110 of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of se

111 ate-age effects that are either neutral (the mutation accumulation hypothesis) or beneficial (the ant

112 The mutation-accumulation hypothesis attributes senescence t

113 es may be exceptionally prone to deleterious-mutation accumulation in both nuclear and organelle gene

114 d a hybrid stochastic-deterministic model of mutation accumulation in both stem cells and progenitors

115 ve a greater ability of delaying the rate of mutation accumulation in colonic stem cells compared to

116 evisiae by whole-genome sequencing following mutation accumulation in each of seven environments with

117 The rate of mutation accumulation in germline cells can be affected

118 But does the rate of mutation accumulation in human gametes differ across fam

119 Bacteria evolve by mutation accumulation in laboratory experiments, but tem

120 The accelerated mutation accumulation in liver was accompanied by an inc

121 from our data that age-related mtDNA somatic mutation accumulation in mouse HSCs is influenced by the

122 sults provide insight into the complexity of mutation accumulation in multicellular organisms and a s

123 d risk reflects an increased rate of somatic mutation accumulation in normal lung cells.

124 We found that mutation accumulation in organoids deficient in the mism

125 High mutation accumulation in runners of strawberry is, we ar

126 Mutation accumulation in somatic cells contributes to ca

127 nvestigate the dynamics of proliferation and mutation accumulation in spatially arranged tissues.

128 es significantly with aging, and the rate of mutation accumulation in the brain is 4.8-fold slower th

129 To compare mutation accumulation in the transcribed genomic regions

130 , .52-1.45]) and no difference in transition mutation accumulation in the viral genome during treatme

131 be strong suppressors of selection, delaying mutation accumulation in this tissue.

132 The mutation accumulation in tumour cell populations has bee

133 To study the impact of NER deficiency on mutation accumulation in vivo, mutant frequencies have b

134 We show that, under mutation accumulation, inbreeding decline and three majo

135 variation underpins evolutionary change, but mutation accumulation increases genetic load.

136 If mutation accumulation is important, their unused functio

137 ral observations, including that the rate of mutation accumulation is maximal during ontogeny, oncoge

138 Mutation accumulation is one of the major genetic theori

139 show that this period is also accompanied by mutation accumulation leading to more de novo mutations

140 es of current human behavior for deleterious-mutation accumulation leads to the conclusion that a sub

141 We further identified STR variation in two mutation accumulation line panels that were derived from

142 gnificant heterogeneity in u among the three mutation-accumulation-line genotypes.

143 eterozygous diploid Saccharomyces cerevisiae mutation accumulation lines across nine genetic backgrou

144 We performed mutation accumulation lines and genome-wide mutational p

145 Analysis of genomic data of yeast mutation accumulation lines and human neutral polymorphi

146 This contrasts with results derived from mutation accumulation lines and suggests that mutation s

147 ed in a large collection of Escherichia coli mutation accumulation lines by analysis of whole genome

148 g 20 million bases of DNA from three sets of mutation accumulation lines by using denaturing high-per

149 Here, we leverage mutation accumulation lines descended from Col-0 accessi

150 s mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natu

151 An analysis of long-term mutation accumulation lines of Caenorhabditis elegans fo

152 We applied this procedure to mutation accumulation lines of Drosophila melanogaster e

153 d elimination of old elements in the Harwich mutation accumulation lines of Drosophila melanogaster,

154 mutation rates of 24 microsatellite loci in mutation accumulation lines of Drosophila melanogaster.

155 The mutation accumulation lines were studied in three enviro

156 e epimutations in clonal or sexually derived mutation accumulation lines, as well as somatic epimutat

157 tes of the gene conversion rate from Daphnia mutation accumulation lines, we are able to age each ase

158 Using genetic assays and mutation accumulation lines, we find that point mutation

159 a long-term series of Caenorhabditis elegans mutation accumulation lines, we performed a wide-scale s

160 iances (VM) for these traits, estimated from mutation accumulation lines, were 4.75 and 1.97 x 10(-4)

161 Here, we used mutation accumulation lines, whole-genome sequencing, an

162 direct genotyping of 96 Arabidopsis thaliana mutation accumulation lines.

163 ions in 274 diploid Saccharomyces cerevisiae mutation accumulation lines.

164 patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to

165 Comparison of the mutation-accumulation lines at generations 19 and 47 wit

166 Here, we show in mutation-accumulation lines of asexual Daphnia that the

167 eliminations have been scored in the Harwich mutation-accumulation lines of Drosophila melanogaster.

168 Using long-term mutation-accumulation lines of the nematode Caenorhabdit

169 lymer mutation assays in a set of C. elegans mutation-accumulation lines reveal an approximately 20-f

170 by mapping QTL that cause divergence between mutation-accumulation lines that have been established f

171 molecular spectrum with a set of C. elegans mutation-accumulation lines that reveal a mutation rate

172 revisiae, we measured the growth rate of 151 mutation-accumulation lines to estimate parameters of mu

173 Using long-term series of mutation-accumulation lines, we have obtained direct est

174 e new predictions to distinguish between the mutation accumulation (MA) and antagonistic pleiotropy (

175 p to evolutionary genetic theories of aging (mutation accumulation (MA) and antagonistic pleiotropy (

176 loid mutator cells with significant lifetime mutation accumulation (MA) exhibited shorter lifespans.

177 During a mutation accumulation (MA) experiment in C. elegans, a 4

178 FVB) maintained for 8 to 15 generations in a mutation accumulation (MA) experiment.

179 ectrum differs between C. elegans laboratory mutation accumulation (MA) experiments and the standing

180 Spontaneous mutation accumulation (MA) experiments have been the pri

181 g the impact of spontaneous mutations is via mutation accumulation (MA) experiments, where lines of s

182 , smaller than typical direct estimates from mutation accumulation (MA) experiments.

183 effect of spontaneous mutations generated by mutation accumulation (MA) experiments.

184 Random mutation accumulation (MA) in yeast frequently reduces u

185 mutation, studying whole genome profiles of mutation accumulation (MA) lineages grown for 11 success

186 mutation, studying whole genome profiles of mutation accumulation (MA) lineages grown for 11 success

187 (changes in cytosine methylation status) in mutation accumulation (MA) lineages of Arabidopsis thali

188 We used two Arabidopsis thaliana mutation accumulation (MA) lines and determined that ove

189 The first, mutation accumulation (MA) lines are the product of main

190 Sequencing of mutation accumulation (MA) lines has provided estimates

191 over five generations in eight MMR-deficient mutation accumulation (MA) lines of the model plant spec

192 wo sets of nematode (Caenorhabditis elegans) mutation accumulation (MA) lines that differ by threefol

193 hod of studying spontaneous mutations is via mutation accumulation (MA) lines.

194 orming a large-scale evolution experiment by mutation accumulation (MA) on multiple hybrid genotypes

195 We performed a 1012-generation mutation-accumulation (MA) experiment in the yeast, Sacc

196 average homozygous mutation effects (s) from mutation-accumulation (MA) experiments in which phenotyp

197 in two Daphnia pulex genotypes via separate mutation-accumulation (MA) experiments.

198 very lines were initiated from a low-fitness mutation-accumulation (MA) line progenitor and allowed t

199 air-deficient (xpa-1) Caenorhabditis elegans mutation-accumulation (MA) lines across 24 regions of th

200 ent (msh-2 and msh-6) Caenorhabditis elegans mutation-accumulation (MA) lines and compared our observ

201 Egg-to-adult viability of 72 nonlethal mutation-accumulation (MA) lines and the controls was as

202 The inbred lines but not the mutation-accumulation (MA) lines showed heterosis for pr

203 rols for assessing viability declines of the mutation-accumulation (MA) lines.

204 ution mutations in 10 Caenorhabditis elegans mutation-accumulation (MA)-line nuclear genomes.

205 After approximately 644 generations of mutation accumulation, MA lines had accumulated an avera

206 e are therefore relevant to the contribution mutation accumulation makes to the genetic underpinnings

207 The data suggest that mutation accumulation may be a major source of standing

208 Reduced fitness from deleterious-mutation accumulation may be important in the evolution

209 Under the mutation accumulation model of senescence, it was predic

210 In contrast to predictions of the mutation accumulation model of senescence, the age-speci

211 d how rearing conditions affect tests of the mutation accumulation model of senescence.

212 The results are consistent with the mutation accumulation model, but can only be explained b

213 ber of replication cycles leading to a rapid mutation accumulation model.

214 population noninfectious - known as the slow mutation accumulation model.

215 However, contrary to the predictions of mutation-accumulation models, inbreeding load for loci a

216 In mutation accumulation, mutations become fixed by genetic

217 After 60 generations of mutation accumulation, negligible changes in mean reprod

218 ll for mutation rather than in the extent of mutation accumulation once targeted.

219 embed genetic theories of senescence (either mutation accumulation or antagonistic pleiotropy) in the

220 rogeneity is witnessed in most cancer types, mutation accumulation patterns can be regularly found an

221 lved via many diverse genetic mechanisms and mutation-accumulation patterns support this inference.

222 stent with a selectionist model, the rate of mutation accumulation per unit time in shoot apical meri

223 Adult germline mutation accumulation rates are established in adolescen

224 uberty may induce the establishment of adult mutation accumulation rates, just when DNA repair system

225 ing the full nonlinear demographic model for mutation accumulation recently developed by Evans, Stein

226 ographic theory includes three main strands--mutation accumulation, stochastic vitality, and optimal

227 roughput time-lapse microscopy on cells from mutation-accumulation strains to precisely infer the dis

228 atches in C. glutamicum in vitro, as well as mutation accumulation studies done in M. smegmatis.

229 magnitude lower than those that are based on mutation accumulation studies.

230 We used a mutation accumulation study to see if unusually high mic

231 Distinctive patterns of somatic mutation accumulation, termed mutational signatures, are

232 by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic

233 This result provides support for the mutation accumulation theory of aging.

234 These results indicate that a modified mutation-accumulation theory can both explain the origin

235 ss all age classes, consistent with modified mutation-accumulation theory.

236 support a prediction derived from MEDAWAR's "mutation accumulation" theory for the evolution of senes

237 r results demonstrate that rates of germline mutation accumulation vary among families with similar a

238 Because of mutation accumulation, viable metapopulations may need t

239 These data suggest that mutation accumulation was an important evolutionary forc

240 M, and G proteins showed that the pattern of mutation accumulation was coherent with fitness changes

241 Mutation accumulation was higher in BCR::ABL1 cells with

242 No increased mutation accumulation was observed in brain or spleen.

243 such mice is due to accelerated spontaneous mutation accumulation, we crossed these mutants with mic

244 To examine the effect of distance in mutation accumulation, we sequenced 320 clones containin

245 ak purifying selection, leads to problematic mutation accumulation when applied to available gut micr

246 se specialists by the relentless pressure of mutation accumulation, which has taken 25 years to detec

247 A time-associated model of mutation accumulation with a constant rate alone cannot

248 in of replication (OriL) to be a hotspot for mutation accumulation with aging in liver.

249 ution of a given variant of a strain through mutation accumulation within an individual, sequential r