ライフサイエンスコーパス: mutation frequency

1 tations into the C. difficile genome (20-50% mutation frequency).

2 les per tumour type, depending on background mutation frequency.

3 nce contributes to genome-wide variations in mutation frequency.

4 ng parent-of-origin-dependent effects on the mutation frequency.

5 er the last 12 years has revealed a 25% PTEN mutation frequency.

6 nes, which leads to DNA damage and increased mutation frequency.

7 C activity of VH1 antibodies correlated with mutation frequency.

8 henotype may arise from the resulting higher mutation frequency.

9 temperature while maintaining an increase in mutation frequency.

10 onstruct may have been responsible for lower mutation frequency.

11 d with enhanced MMR efficiency and decreased mutation frequency.

12 of reactive nitrogen species or reduction in mutation frequency.

13 mutation efficiency on HBV DNA and total HBV mutation frequency.

14 quent first-cousin marriages and/or a higher mutation frequency.

15 ave been suggested, one of them being simple mutation frequency.

16 uated isoLG adducts, DNA damage, and somatic mutation frequency.

17 ype, and disease site were not predictive of mutation frequency.

18 r, it is unknown if filoviruses exhibit high mutation frequencies.

19 are preferential targets for altered somatic mutation frequencies.

20 utation frequencies comparable to background mutation frequencies.

21 target regions in which nucleotides have low mutation frequencies.

22 utators, which exhibit increased spontaneous-mutation frequencies.

23 mapping of polymorphisms and measurement of mutation frequencies.

24 and marked genetic heterogeneity, with high mutation frequencies.

25 on the analysis of HIV strains, rather than mutation frequencies.

26 ity that conditions on per-event, per-sample mutation frequencies.

27 two orders of magnitude higher than somatic mutation frequencies.

28 We found mtDNA mutation frequencies 2- to 3-fold higher in 10-month-old

29 However, the most significant reduction in mutation frequency (50%-70%) was observed upon simultane

30 ant activity correlates imperfectly with its mutation frequency across breast cancer populations.

31 onal processes and disease aetiology, and in mutation frequency across the genome, which is strongly

32 RAF; 15% NRAS), a nonsignificant increase in mutation frequency after progression from primary melano

33 AP site with nuclear extract and an elevated mutation frequency after transformation into wild-type o

34 Mouse models that harbor elevated mtDNA mutation frequencies age prematurely; these findings wer

35 Mutation frequencies among clear cell RCCs were as follo

36 icularly useful for doped selections such as mutation frequency analysis, information content calcula

37 ubmitted to whole-genome sequencing prior to mutation frequency analysis.

38 t a mutant of the beta clamp causes elevated mutation frequencies and is reduced for MutS-GFP focus f

39 Mutation frequencies and patterns differed between germl

40 hology and ethnic occurrence, accompanied by mutation frequencies and references.

41 uals studied (19 and 23 years old) had lower mutation frequencies and smaller foci at both mutation s

42 ere are no good assays for comparing somatic mutation frequencies and spectra between different verte

43 We determined non-B DNA-induced mutation frequencies and spectra in human U2OS osteosarc

44 equencing assay for the determination of HIV mutation frequencies and spectra using the Illumina sequ

45 but not subtype significantly affects viral mutation frequencies and spectra.

46 and other steps for analyzing damage-induced mutation frequencies and spectra.

47 The differential mutation frequencies and structural variation patterns i

48 ity coincided with a significant increase in mutation frequency and a shift in the HIV mutation spect

49 hyde-induced crosslinks results in increased mutation frequency and an altered mutational spectrum co

50 Modeling of the relationship of mutation frequency and drug concentration showed an asym

51 fections reveal a strong correlation between mutation frequency and fitness.

52 notably from that of MZ B cells by a higher mutation frequency and lower VH4 and higher JH6 gene usa

53 position, protein structure, tRNA abundance, mutation frequency and patterns, and GC compositions.

54 To further define the mutation frequency and phenotypes associated with mutati

55 We will present how this may affect the mutation frequency and population dynamics.

56 This retrospective study reports the mutation frequency and spectrum of BRCA1 and BRCA2 mutat

57 A descriptive analysis of mutation frequency and spectrum was performed for Hispan

58 airs and discover extraordinary variation in mutation frequency and spectrum within cancer types, whi

59 Taken together, the extremely high mutation frequency and strand specificity of mutations p

60 muNeil3 greatly reduced both the spontaneous mutation frequency and the level of FapyG in the DNA, su

61 family member would necessarily have a lower mutation frequency and thus not identified as significan

62 h age, which would contribute to an enhanced mutation frequency and tumorigenesis in the aging proces

63 a and hemiplegic migraine to investigate the mutation frequency and type and the genetic and phenotyp

64 quencing (RNA-seq) to investigate the genome mutation frequency and viral mRNA accumulation in HRSV-i

65 ncreased levels of genomic uracil, increased mutation frequencies, and C-to-T transitions.

66 n D270A/D271A mutations, exhibited increased mutation frequencies, and mutants containing the Q282R m

67 and C-->T transversion mutations, increased mutation frequency, and a shift of the nucleotide profil

68 This change was reflected in the overall mutation frequency, and it was associated with an increa

69 results in rapid mtDNA depletion, increased mutation frequency, and mitochondrial dysfunction.

70 g revealed that NHEJ at 5' DSBs had a higher mutation frequency, and validated the differential requi

71 Fpg, MutY or Smn showed elevated spontaneous mutation frequencies; and, these mutator phenotypes corr

72 Instead, we find foci where C758G mutation frequencies are 3-4 orders of magnitude greater

73 w that propionaldehyde is a mutagen and that mutation frequencies are increased in MCP-minus mutants

74 Variants with the highest mutation frequencies are less fit in vivo and fail to pr

75 However, mutation frequencies are not reduced in a mutY mutator b

76 FLT3-ITD demonstrated a relative increase in mutation frequency as detected by thymidine kinase (TK)

77 Mutation frequencies at the site of the lesions in the o

78 use B cells that correlates with an impaired mutation frequency at 5'Smu.

79 Here, we have analysed the mutation frequency at an expanded simple tandem repeat (

80 ites and to a lesser extent by elevating the mutation frequency at existing sites even before the pre

81 ol zeta-deficient B cells had a reduction in mutation frequency at Ig loci in the spleen and in Peyer

82 a particular gene, simultaneous analysis of mutation frequency at multiple genetic loci is feasible.

83 BLM in the WRN- ALT+ cell line increased the mutation frequency at telomeres and at the MS32 minisate

84 ' against DSB formation but does enhance the mutation frequency at the site of 8-oxoG relative to tha

85 and IgG3, which was associated with reduced mutation frequency at the switch regions and a bias towa

86 ariants, we used deep sequencing to quantify mutation frequencies before and after selection.

87 itiate corresponds to the zone where the AID mutation frequency begins to rise, despite a constant de

88 Kingdom was performed to detect DRMinVs at a mutation frequency between 2% and 20%.

89 Less-responsive cells exhibit increased mutation frequencies but resume wild-type behavior.

90 train-dependent increases in the spontaneous-mutation frequency but also shifts in mutational type an

91 no growth defects or changes in spontaneous mutation frequency but had increased sensitivity to UV i

92 Enhanced pS38 elevated Myc translocation and mutation frequency but not CSR or Ig switch region mutat

93 Some non-coding regions exhibited high mutation frequencies, but most have distinctive structur

94 e radiosensitization nor did it increase the mutation frequency, but after short hairpin RNA-directed

95 -2'-deoxycytidine were found to increase the mutation frequency by 3.1- and 3.4-fold, respectively.

96 aDMutNetEx discovers cancer drivers with low mutation frequency by giving preference to genes encodin

97 of either hPol iota or hPol zeta reduced the mutation frequency by nearly 50%.

98 cultured, cellular movement altered observed mutation frequency by up to 18.5%.

99 t 49 degrees C, and they show an increase in mutation frequency caused by a partial defect in MMR at

100 nstability (MSI) and an elevated spontaneous mutation frequency, characteristic of MMR-deficient cell

101 treated with RNA-guided nucleases that have mutation frequencies close to 100% at targeted sites.

102 that cancer susceptibility regions have gene mutation frequencies comparable to background mutation f

103 Primary XP-C cells had increased UV-induced mutation frequencies compared with normal cells, consist

104 ximately 10% of normal) of WRN have elevated mutation frequencies compared with wild-type cells.

105 kewed CDR3 length distribution and increased mutation frequency compared with naive B cells.

106 is 100-1,000 times more common than genomic mutation frequency data predict.

107 ervations support a model in which increased mutation frequency decreases infectivity through lethal

108 with significant increases in break-induced mutation frequencies, deletion lengths and the annealing

109 RB inversely correlated with mutation frequency, demonstrating a key difference betwe

110 We find that BRAF mutation frequencies depend on the equilibrium between t

111 not increase mitochondrial point or deletion mutation frequencies, despite evidence both compounds in

112 Mutation frequencies did not differ according to whether

113 l population reached a threshold after which mutation frequency did not correlate with a dose-depende

114 DNA glycation is associated with increased mutation frequency, DNA strand breaks, and cytotoxicity.

115 a resulted in significant decreases in T-->C mutation frequencies for all the O(4)-alkyldT lesions ex

116 Pol nu and Pol theta resulted in diminished mutation frequencies for all three O (6)-alkyl-dG lesion

117 id not lead to any detectable alterations in mutation frequencies for any of the O(2)-alkyldT lesions

118 iling of ctDNA in advanced HCC shows similar mutation frequencies for known HCC drivers compared to e

119 t was not accompanied by marked increases in mutation frequencies for several traits tested.

120 The mutation frequencies for the purified enzyme in vitro va

121 resulting in a damage-dependent increase in mutation frequency for alpha-acetoxytamoxifen; 4-OHtamQM

122 r subtypes (eg, CMT1, CMT2) and the observed mutation frequency for CMT genes.

123 Ultradeep sequencing revealed that the mutation frequency for EBOV was high and similar to thos

124 We analyzed mutation frequencies from the liver tissue of animals wi

125 ed phenotype (>12 mutations/megabase); 6 had mutation frequencies >200/megabase, and 5 of these had s

126 Furthermore, knowledge of mutation frequency has predictive power for downstream c

127 pathways may play a wider role in modulating mutation frequencies in different parts of the genome th

128 incorporate empirical data on CRISPR-induced mutation frequencies in Drosophila.

129 We measured mutation frequencies in genes encoding replicative DNA p

130 C and/or OC were compared with the FANCM LoF mutation frequencies in geographically matched controls

131 oups based on high, low, or background-level mutation frequencies in human melanomas, and we further

132 The mutation frequencies in mice correlated with those in tw

133 Mutation frequencies in OC were compared with the Nation

134 FANCM LoF mutation frequencies in patients with BC and/or OC were

135 Mutation frequencies in SMRs demonstrate that distinct p

136 Tet2(-/-) Lin(-)c-Kit(+) cells shows higher mutation frequencies in Tet2(-/-) cells.

137 Our genetic screening revealed varying mutation frequencies in the FZD4 (8.0 %), TSPAN12 (5.4 %

138 icients to find the expected distribution of mutation frequencies in the population.

139 Hence, we measured APOBEC3B-induced CAN1 mutation frequencies in yeast deficient in BER endonucle

140 Importantly, we found 41.9% NOTCH1 mutation frequency in aggressive trisomy 12 CLL cases.

141 tric oxide (NO), significantly decreased the mutation frequency in both bystander rho(o) and rho(+) c

142 mpaired or kinase-dead BRAF have the highest mutation frequency in BRAF gene in lung adenocarcinoma.

143 To provide a more definitive figure for Ras mutation frequency in cancer, we cross-referenced the da

144 nd blood correlate with lower regional CpG>T mutation frequency in cancers originating in the respect

145 opy number, which may be favored by a higher mutation frequency in cells expressing the oncoprotein.

146 unctional nucleotide insertions and a higher mutation frequency in D and J segments than normal.

147 In UVA-irradiated cells, the increase in the mutation frequency in deficient cells included a remarka

148 new members, we determined mSWI/SNF subunit mutation frequency in exome and whole-genome sequencing

149 revealed a ribavirin-associated elevation in mutation frequency in HTNV vRNA similar to that previous

150 nome of primary cells significantly reflects mutation frequency in malignant melanoma.

151 ied- and UVC-irradiated DNAs induce a higher mutation frequency in MCs than in NHSFs; and, XP complem

152 uding the BRAF oncogene that has the highest mutation frequency in melanoma.

153 r level in mice, and we demonstrate that the mutation frequency in mouse mitochondria is more than te

154 capture (RMC) assay to measure nuclear point mutation frequency in mouse tissue is described.

155 Increased mutation frequency in mtDNA of CSB-deficient cells demon

156 We evaluated 100 probands to determine the mutation frequency in MYH11, ACTA2, TGFbetaRI, and TGFbe

157 strains but a slight increase in T:A to C:G mutation frequency in NER-proficient strains.

158 Rp22 showed a significantly lower (P< 0.001) mutation frequency in nsp2, which is one of the most var

159 enic Pol zeta displayed a marked increase in mutation frequency in Peyer's patches, revealing a patte

160 Our study had 80% power to detect a 4.9% mutation frequency in POAG patients.

161 fidelity than other retroviruses and shows a mutation frequency in the 10(-5) range.

162 gements and demonstrated a low somatic point mutation frequency in the absence of tobacco mutagens.

163 layed a higher N-ethyl-N-nitrosourea-induced mutation frequency in the colon than p27(+/+) littermate

164 e report a significant increase in the mtDNA mutation frequency in the hippocampus of early stage AD,

165 f ubiquitylated PCNA and significantly lower mutation frequency in the tailless H2A/H3 mutant, indica

166 The mutation frequency in this group was 1.6-fold higher tha

167 of poleta significantly elevates spontaneous mutation frequency in various organs and tissues of the

168 ding at promoter elements, and increases the mutation frequency in vivo.

169 A significantly reduced mutation frequency in WA motifs compared with normal don

170 cient in ODD repair and ODD induces a higher mutation frequency in XPA cells than in NHSFs.

171 Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN1

172 wed that the HUWE1 expression is altered and mutation frequency increased in three different XLID ind

173 DEA/NO had significantly higher spontaneous mutation frequencies, increased numbers of AP sites in D

174 The most effective BNAbs have very high mutation frequencies, indicative of the long periods of

175 The mutation frequencies induced by CRISPR/LbCas12a at a sin

176 ncer genomics and precision medicine, as the mutation frequency is low, and targeted therapies are le

177 it can affect clinical outcome, because the mutation frequency is rare, genetic testing is not stand

178 Moreover, this mutation frequency is sufficient for pushing a viral pop

179 regions of clustered mutations in which the mutation frequency is ~7 x 10(-4) Mutational spectra sho

180 BnAbs exhibit high somatic mutation frequencies, long third heavy-chain complementa

181 Mutation frequencies measured in vivo equal those measur

182 Mutation frequency (MF) of dG-C8-IQ was reduced by 38-67

183 yed recovery after UV-C damage and increased mutation frequency, micronuclei and sister chromatin exc

184 dels in the coding sequence, with an average mutation frequency more than 10-fold higher in smokers t

185 ( approximately 0.08% in both cases) and the mutation frequencies observed with a number of DNA polym

186 We then show that the increased CpG mutation frequency observed in some cancers primarily oc

187 inimal off-target mutagenesis and with indel mutation frequencies of 40-50% and homology-directed rep

188 press the ADH1 or TT4 ZFNs exhibited somatic mutation frequencies of 7% or 16%, respectively.

189 PCR-based methods may underestimate mutation frequencies of heterogeneous tumor genomes.

190 air GAP-assisted GTP --> GDP hydrolysis, the mutation frequencies of K-Ras4B in human cancers vary.

191 Current approaches are primarily based on mutation frequencies of single-genes, which lack the pow

192 is supported by early clinical evidence, the mutation frequencies of these and other functionally rel

193 polymerases does not result in alteration of mutation frequencies of these two lesions.

194 AID silencing did not decrease the mutation frequencies of tumor Ag gene P1A.

195 BRCA1 or BRCA2 mutation, was designed using mutation frequencies of white and Ashkenazi Jewish popul

196 Transformed cells exhibited lower rare mutation frequencies of whole mtDNA than did normal stem

197 Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and n

198 of 2.05 (95% CI, 0.94-4.54; P = .049) and a mutation frequency of 1.03% in index cases.

199 itional VEFS domain mutant, yielding a total mutation frequency of 1.4% (2 of 148).

200 er family with DA1, accounting for an MYBPC1 mutation frequency of 13% (two of 15).

201 CH98 had a mutation frequency of 25% and 15% nt somatic mutations i

202 y mutated gene in PTNFL was TNFRSF14, with a mutation frequency of 29%, similar to that seen in limit

203 primary tumours, corresponding to an overall mutation frequency of 4.5%.

204 e in PTNFL was MAP2K1, encoding MEK1, with a mutation frequency of 43%.

205 following replication in COS-7 cells, with a mutation frequency of 45%.

206 ty-purified CCCs and CCC cell lines showed a mutation frequency of 46%.

207 g(K164R) mice a significant reduction in the mutation frequency of A:T residues in WA motifs preferre

208 The Ig mutation frequency of all V(H) genes from AICDA(-/-) pat

209 Our reanalysis supports a mutation frequency of approximately 0.2 events per cell,

210 ncer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independen

211 the cross-linked dG component occurred at a mutation frequency of approximately 8%.

212 Besides the high mutation frequency of CDH1 in 65% of tumors, alterations

213 We determined the spontaneous mutation frequency of EBOV, which is relevant to underst

214 otein were used to determine the spontaneous mutation frequency of EBOV.

215 This implies that the mutation frequency of foci increases as adults age, and

216 Poleta), and a strand-biased increase in the mutation frequency of G residues, preferentially in the

217 At a postconceptional age of 60 wk, somatic mutation frequency of IgA H chain transcripts reached 25

218 less than that of normal donors, whereas the mutation frequency of mutated V(H) sequences from AICDA(

219 The median mutation frequency of off-target events was 0.05% (range

220 es double-strand DNA breaks and enhances the mutation frequency of proto-oncogenes and tumor suppress

221 ensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying fr

222 provide a mechanistic basis for the elevated mutation frequency of RNA phage relative to animal RNA v

223 tions of mutational signatures shift and the mutation frequency of six known driver genes increases i

224 We found that the mutation frequency of the inserted Sgamma1 region was dr

225 The mutation frequency of the ovarian cancer cell line A2780

226 The polyclonality and low mutation frequency of these VH1 antibodies reveal fundam

227 Thus, we aimed at identifying the mutation frequency of TP53, its association with cytogen

228 and infectious virus, only RBV increased the mutation frequency of viral RNA (vRNA).

229 n the vicinity of the lesion, with a maximum mutation frequency of ~1%.

230 Measures: Clinical categorization of somatic mutations; frequencies of deleterious germline mutations

231 CT-->TAT and TCG-->TTG mutations and overall mutation frequencies often exceeding 100 mutations/Mb.

232 ggest that the oxidative stress induced high mutation frequency on mtDNA can be indirectly caused by

233 ficiency had no additional effect on the DNA mutation frequency or spectrum in Ung(-/-) or wild-type

234 ion, we made a comprehensive analysis of the mutation frequency over several RBV concentrations.

235 tch-containing guide RNA also increases CAN1 mutation frequency, particularly in an ung1Delta mutant

236 le therapeutic target as the result of ahigh mutation frequency, PIK3CA mutations do not seem to affe

237 OxodG mutation frequencies ranged from 3.1% to 9.8%, whereas t

238 apping revealed that the control elements of mutation frequency reside within the first 596 amino aci

239 s resulted in a 12- and 160-fold increase in mutation frequency, respectively, and gave rise to varia

240 everal methods, we show that the increase in mutation frequency resulting from each dnaN allele is li

241 ults demonstrate that EBOV has a spontaneous mutation frequency similar to those of other RNA viruses

242 ta-esterase activities, but not in Vgsc gene mutation frequency, suggesting metabolic detoxification

243 nt age is positively correlated with somatic mutation frequency, suggesting that some poly-G variants

244 and MMC/uvrD double mutants exhibited higher mutation frequencies than any single mutant.

245 These mice exhibited significantly higher mutation frequencies than did wild-type animals.

246 ple sclerosis (RRMS) have higher replacement mutation frequencies than observed in healthy controls o

247 with regulator-encoding genes having higher mutation frequencies than the genome average.

248 These mutator strains generate higher mutation frequencies than WT virus and are more sensitiv

249 were targeted by SHM and displayed a higher mutation frequency than functional sequences.

250 MNNG displayed approximately 15-fold higher mutation frequency than parental counterparts and predom

251 fected hybridomas had a significantly higher mutation frequency than those in the uninfected hybridom

252 train of Rev1 exhibits a lower 4-NQO-induced mutation frequency than wild type.

253 rmal and CS-B cells had increased background mutation frequencies that decreased upon irradiation, pu

254 assified into these subgroups do not display mutation frequencies that deviate from those expected.

255 non-B DNA and WRN-KD served to increase the mutation frequency, the increase afforded by WRN-KD was

256 ributed to its ability to increase the HIV-1 mutation frequency through viral-DNA incorporation durin

257 The MP2 sequence significantly reduces the mutation frequency throughout the nucleosome, and especi

258 cate that, although RNA viruses have extreme mutation frequencies to maximize adaptability, nature ha

259 hogenicity led to a further reduction of the mutation frequency to 0.024.

260 coverage correlated the c.2187_2188insA ADNP mutation frequency to Braak stage (tauopathy) and showed

261 Efflux-pump blockage reduced the mutation frequency to ethambutol 64-fold.

262 leles showed a dominant negative increase in mutation frequency to wild-type mutL.

263 We illustrate the distributions of mutation frequencies, types and contexts across tumour t

264 cer mutation databases to determine reliable mutation frequency values for each Ras isoform in all ma

265 Mutation frequencies varied from 1/1000- to 1000-fold gr

266 onstrate that target DNA sequences influence mutation frequency via regulating AID recruitment.

267 Mutation frequency was >10%: SF3B1 (74.5%), TET2 (45.7%)

268 mal shuttle vector, the psoralen-PNA-induced mutation frequency was 0.13%, 3.5-fold higher than the b

269 EGFR mutation frequency was 22.1% in NSCLC, and erlotinib ach

270 KRAS mutation frequency was 24.9% in NSCLC, and selumetinib f

271 in which an approximately 3-fold increase in mutation frequency was found compared with the normal le

272 The mutation frequency was lower than found in germinal cent

273 BV, GTP levels, specific infectivity, and/or mutation frequency was measured in the presence of RBV,

274 In contrast, ESTR mutation frequency was only slightly elevated in the off

275 c potential of the beta-anomer in vitro, the mutation frequency was significantly reduced when condit

276 evealed that ERBB2/HER2 amplification and/or mutation frequency was unchanged between local disease a

277 This increase in mutation frequency was validated with independent WES da

278 Resistance to rifampin, an indicator for mutation frequency, was found to increase approximately

279 , can influence AID targeting efficiency and mutation frequency, we established a knock-in mouse mode

280 Mutation frequencies were correlated to the 3 TIME types

281 MS2, EPCAM, POLE, and POLD1 with ColoSeq and mutation frequencies were established.

282 Increased mutation frequencies were observed in samples from treat

283 e three drugs, expanded simple tandem repeat mutation frequencies were significantly elevated in the

284 Mutation frequencies were similar in prospectively colle

285 In contrast to OxodG bypass, Fapy.dG mutation frequencies were unaffected by carrying out exp

286 Antiviral activity and increased mutation frequency were also associated with the late ph

287 of nonsynonymous (K(a)) to synonymous (K(s)) mutation frequency were calculated for codons in the sia

288 tional frequency over the background somatic mutation frequency were calculated for each tumor type b

289 esults also demonstrated that 100% and 98.8% mutation frequency were occurred on GhMYB25-like-sgRNA1

290 characterized by altered in vitro population mutation frequencies, were used to evaluate how intrahos

291 creased DNA double-strand breaks, and higher mutation frequencies when compared with HPV-negative cel

292 lta results in a similar 30-fold increase in mutation frequency when copying gapped DNA templates.

293 es and did not have an appreciable effect on mutation frequency when separated from G73R.

294 ons in the exonuclease domain result in high mutation frequencies with a preference for C-->A mutatio

295 nvestigated the association of T790M and its mutation frequencies with clinical outcome.

296 Although there is only a mild increase in mutation frequency with sequential TKI treatment, novel

297 ancer genomes exhibited substantially higher mutation frequencies, with 2,000-4,000 novel coding vari

298 correlated with elongation rates and in vivo mutation frequencies, with faster polymerases having low

299 However, the mutation frequencies within the two publically available

300 Measuring mutation frequency within an intron of a transcribed gen